Thomas Gould

Jean Phillips Shibley Professor and Department Head of Biobehavioral Health

Thomas Gould

Research Summary

Using genetic, pharmacological, behavioral, and molecular biological techniques to study the neurobiology of learning and memory and the effects of addiction on it.

Huck Affiliations


Publication Tags

Nicotine Fear Conditioning (Psychology) Learning Hippocampus Nicotinic Receptors Prefrontal Cortex Genes Cognition Psychological Extinction Brain Derived Neurotrophic Factor Neuronal Plasticity Self Administration Inhibition (Psychology) Inbred C57bl Mouse Epigenomics Up Regulation Long Term Memory Memory Consolidation Knockout Mice Choline Neuregulins Histones Gyrus Cinguli Amyloid

Most Recent Papers

Adolescent and adult nicotine exposure differentially impacts oral nicotine and oral saccharin self-administration in mice

Robert D. Cole, Cassandra Wolsh, Matty Zimmerman, Evelynn Harrington, Thomas J. Gould, Vinay Parikh, 2019, Behavioural Brain Research on p. 836-844

Cognitive rigidity and BDNF-mediated frontostriatal glutamate neuroadaptations during spontaneous nicotine withdrawal

Robert D. Cole, Matty Zimmerman, Anastasia Matchanova, Munir Gunes Kutlu, Thomas J. Gould, Vinay Parikh, 2019, Neuropsychopharmacology

Paternal nicotine enhances fear memory, reduces nicotine administration, and alters hippocampal genetic and neural function in offspring

Lisa R. Goldberg, Dana Zeid, Munir Gunes Kutlu, Robert D. Cole, Valeria Lallai, Aswathy Sebastian, Istvan Albert, Christie D. Fowler, Vinay Parikh, Thomas J. Gould, 2019, Addiction Biology

Stress and nicotine during adolescence disrupts adult hippocampal-dependent learning and alters stress reactivity

Erica D. Holliday, Sheree F. Logue, Chicora Oliver, Debra A. Bangasser, Thomas J. Gould, 2019, Addiction Biology

Choline ameliorates adult learning deficits and reverses epigenetic modification of chromatin remodeling factors related to adolescent nicotine exposure

Miri Gitik, Erica D. Holliday, Ming Leung, Qiaoping Yuan, Sheree F. Logue, Roope Tikkanen, David Goldman, Thomas J. Gould, 2018, Neurobiology of Learning and Memory on p. 239-248

Nicotine modulates contextual fear extinction through changes in ventral hippocampal GABAergic function

Munir Gunes Kutlu, David A. Connor, Jessica M. Tumolo, Courtney Cann, Brendan Garret, Thomas J. Gould, 2018, Neuropharmacology on p. 192-200

The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse

Sean M. Mooney-Leber, Thomas J. Gould, 2018, Learning and Memory on p. 481-491

Chronic nicotine exposure in preadolescence enhances later spontaneous recovery of fear memory

Dana Zeid, Thomas J. Gould, 2018, Behavioral Neuroscience on p. 240-246

Neuregulin 3 Signaling Mediates Nicotine-Dependent Synaptic Plasticity in the Orbitofrontal Cortex and Cognition

Luyi Zhou, Miranda L. Fisher, Robert D. Cole, Thomas J. Gould, Vinay Parikh, Pavel I. Ortinski, Jill R. Turner, 2018, Neuropsychopharmacology on p. 1343-1354

Nicotine exposure leads to deficits in differential cued fear conditioning in mice and humans

Munir Gunes Kutlu, Marie France Marin, Jessica M. Tumolo, Navneet Kaur, Michael B. VanElzakker, Lisa M. Shin, Thomas J. Gould, 2018, Neuroscience letters on p. 142-149

Most-Cited Papers

The neural and genetic basis of executive function

Sheree F. Logue, Thomas J. Gould, 2014, Pharmacology Biochemistry and Behavior on p. 45-54

Diet-induced hyperhomocysteinemia increases amyloid-β formation and deposition in a mouse model of Alzheimer's disease

J. M. Zhuo, G. S. Portugal, W. D. Kruger, H. Wang, Thomas J. Gould, D. Praticò, 2010, Current Alzheimer Research on p. 140-149

Gadd45b knockout mice exhibit selective deficits in hippocampus-dependent long-term memory

Prescott T. Leach, Shane G. Poplawski, Justin W. Kenney, Barbara Hoffman, Dan A. Liebermann, Ted Abel, Thomas J. Gould, 2012, Learning and Memory on p. 319-324

The role of nicotinic acetylcholine receptors in the medial prefrontal cortex and hippocampus in trace fear conditioning

J. D. Raybuck, T. J. Gould, 2010, Neurobiology of Learning and Memory on p. 353-363

The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation

Thomas J. Gould, George S. Portugal, Jessica M. André, Matthew P. Tadman, Michael J. Marks, Justin W. Kenney, Emre Yildirim, Michael Adoff, 2012, Neuropharmacology on p. 2118-2125

Effects of chronic low- and high-dose nicotine on cognitive flexibility in C57BL/6J mice

Leonardo A. Ortega, Brittany A. Tracy, Thomas J. Gould, Vinay Parikh, 2013, Behavioural Brain Research on p. 134-145

Targeted deletion of the mouse α2 nicotinic acetylcholine receptor subunit gene (Chrna2) potentiates nicotine-modulated behaviors

Shahrdad Lotfipour, Janet S. Byun, Prescott Leach, Christie D. Fowler, Niall P. Murphy, Paul J. Kenny, Thomas J. Gould, Jim Boulter, 2013, Journal of Neuroscience on p. 7728-7741

Involvement of hippocampal Jun-N terminal kinase pathway in the enhancement of learning and memory by nicotine

Justin W. Kenney, Cédrick Florian, George S. Portugal, Ted Abel, Thomas J. Gould, 2010, Neuropsychopharmacology on p. 483-492

Strain-dependent effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning

George S. Portugal, Derek S. Wilkinson, Justin W. Kenney, Colleen Sullivan, Thomas J. Gould, 2012, Behavior Genetics on p. 133-150

17β-estradiol regulates histone alterations associated with memory consolidation and increases Bdnf promoter acetylation in middle-aged female mice

Ashley M. Fortress, Jaekyoon Kim, Rachel L. Poole, Thomas J. Gould, Karyn M. Frick, 2014, Learning and Memory on p. 457-467