Thomas Gould

Jean Phillips Shibley Professor and Department Head of Biobehavioral Health

Thomas Gould

Research Summary

Using genetic, pharmacological, behavioral, and molecular biological techniques to study the neurobiology of learning and memory and the effects of addiction on it.

Huck Graduate Students

Huck Affiliations


Publication Tags

Nicotine Learning Hippocampus Fear Conditioning (Psychology) Memory Therapeutics Pharmaceutical Preparations Inbred C57bl Mouse Corticosterone Alcohols Cocaine Inhibition (Psychology) Psychological Inhibition Street Drugs Rodentia Maintenance Neurotransmitter Agents Substance Related Disorders Anxiety Recognition (Psychology) Psychology Recognition Prefrontal Cortex Tobacco Use Disorder Cognitive Dysfunction

Most Recent Papers

Adult and adolescent C57BL/6J and DBA/2J mice are differentially susceptible to fear learning deficits after acute ethanol or MK-801 treatment

L. R. Seemiller, T. J. Gould, 2021, Behavioural Brain Research

Therapeutic potential of ketamine for alcohol use disorder

Stephen D. Worrell, Thomas J. Gould, 2021, Neuroscience and Biobehavioral Reviews on p. 573-589

Adolescent Stress Reduces Adult Morphine-Induced Behavioral Sensitization in C57BL/6J Mice

Helen M. Kamens, Carley N. Miller, Jasmine I. Caulfield, Dana Zeid, William J. Horton, Constanza P. Silva, Aswathy Sebastian, Istvan Albert, Thomas J. Gould, Diana Fishbein, Patricia Sue Grigson, Sonia A. Cavigelli, 2021, Frontiers in Behavioral Neuroscience

Multigenerational nicotine exposure affects offspring nicotine metabolism, nicotine-induced hypothermia, and basal corticosterone in a sex-dependent manner

Dana Zeid, Lisa R. Goldberg, Laurel R. Seemiller, Sean Mooney-Leber, Philip B. Smith, Thomas J. Gould, 2021, Neurobehavioral toxicology

Genes and Behavior: Animal Models

Thomas Gould, L Goldberg, 2021, Encyclopedia of Behavioural Neuroscience 2e

Systems genetic analysis of nicotine withdrawal deficits in hippocampus-dependent learning

Lisa R. Goldberg, Munir Gunes Kutlu, Dana Zeid, Laurel R. Seemiller, Thomas J. Gould, 2021, Genes, Brain and Behavior

Impact of nicotine, alcohol, and cocaine exposure on germline integrity and epigenome

Dana Zeid, Thomas J. Gould, 2020, Neuropharmacology

The effects of adolescent alcohol exposure on learning and related neurobiology in humans and rodents

Laurel R. Seemiller, Thomas J. Gould, 2020, Communications in behavioral biology. Part A: [Original articles]

Stress and nicotine during adolescence disrupts adult hippocampal-dependent learning and alters stress reactivity

Erica D. Holliday, Sheree F. Logue, Chicora Oliver, Debra A. Bangasser, Thomas J. Gould, 2020, Addiction Biology

Cognitive rigidity and BDNF-mediated frontostriatal glutamate neuroadaptations during spontaneous nicotine withdrawal

Robert D. Cole, Matty Zimmerman, Anastasia Matchanova, Munir Gunes Kutlu, Thomas J. Gould, Vinay Parikh, 2020, Neuropsychopharmacology on p. 866-876

Most-Cited Papers

The neural and genetic basis of executive function: Attention, cognitive flexibility, and response inhibition

Sheree F. Logue, Thomas J. Gould, 2014, Pharmacology Biochemistry and Behavior on p. 45-54

Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory

Munir Gunes Kutlu, Thomas J. Gould, 2016, Learning and Memory on p. 515-533

Developmental toxicity of nicotine

Lucinda J. England, Kjersti Aagaard, Michele Bloch, Kevin Conway, Kelly Cosgrove, Rachel Grana, Thomas J. Gould, Dorothy Hatsukami, Frances Jensen, Denise Kandel, Bruce Lanphear, Frances Leslie, James R. Pauly, Jenae Neiderhiser, Mark Rubinstein, Theodore A. Slotkin, Eliot Spindel, Laura Stroud, Lauren Wakschlag, 2017, Neuroscience and Biobehavioral Reviews on p. 176-189

Gadd45b knockout mice exhibit selective deficits in hippocampus-dependent long-term memory

Prescott T. Leach, Shane G. Poplawski, Justin W. Kenney, Barbara Hoffman, Dan A. Liebermann, Ted Abel, Thomas J. Gould, 2012, Learning and Memory on p. 319-324

Developmental effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning

George S. Portugal, Derek S. Wilkinson, Jill R. Turner, Julie A. Blendy, Thomas J. Gould, 2012, Communications in behavioral biology. Part A: [Original articles] on p. 482-494

The effects of acute, chronic, and withdrawal from chronic nicotine on novel and spatial object recognition in male C57BL/6J mice

Justin W. Kenney, Michael D. Adoff, Derek S. Wilkinson, Thomas J. Gould, 2011, Psychopharmacology on p. 353-365

Negative affective states and cognitive impairments in nicotine dependence

F. Scott Hall, Andre Der-Avakian, Thomas J. Gould, Athina Markou, Mohammed Shoaib, Jared W. Young, 2015, Neuroscience and Biobehavioral Reviews on p. 168-185

Reactivation of cocaine reward memory engages the Akt/GSK3/mTOR signaling pathway and can be disrupted by GSK3 inhibition

Xiangdang Shi, Jonathan S. Miller, Lauren J. Harper, Rachel L. Poole, Thomas J. Gould, Ellen M. Unterwald, 2014, Psychopharmacology on p. 3109-3118

The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation

Thomas J. Gould, George S. Portugal, Jessica M. André, Matthew P. Tadman, Michael J. Marks, Justin W. Kenney, Emre Yildirim, Michael Adoff, 2012, Neuropharmacology on p. 2118-2125

17β-estradiol regulates histone alterations associated with memory consolidation and increases Bdnf promoter acetylation in middle-aged female mice

Ashley M. Fortress, Jaekyoon Kim, Rachel L. Poole, Thomas J. Gould, Karyn M. Frick, 2014, Learning and Memory on p. 457-467