Thomas Gould

Jean Phillips Shibley Professor and Department Head of Biobehavioral Health

Thomas Gould

Research Summary

Using genetic, pharmacological, behavioral, and molecular biological techniques to study the neurobiology of learning and memory and the effects of addiction on it.

Huck Graduate Students

Huck Affiliations


Publication Tags

Nicotine Learning Fear Conditioning (Psychology) Memory Hippocampus Pharmaceutical Preparations Cocaine Alcohols Epigenomics Street Drugs Nicotinic Receptors Corticosterone Genes Inhibition (Psychology) Phenotype Substance Related Disorders Self Administration Tobacco Use Disorder Rodentia Paternal Exposure Maintenance Cognitive Dysfunction Inbred C57bl Mouse Tobacco Products

Most Recent Papers

Multigenerational nicotine exposure affects offspring nicotine metabolism, nicotine-induced hypothermia, and basal corticosterone in a sex-dependent manner

Dana Zeid, Lisa R. Goldberg, Laurel R. Seemiller, Sean Mooney-Leber, Philip B. Smith, Thomas J. Gould, 2021, Neurotoxicology and Teratology

Systems genetic analysis of nicotine withdrawal deficits in hippocampus-dependent learning

Lisa R. Goldberg, Munir Gunes Kutlu, Dana Zeid, Laurel R. Seemiller, Thomas J. Gould, 2021, Genes, Brain and Behavior

Impact of nicotine, alcohol, and cocaine exposure on germline integrity and epigenome

Dana Zeid, Thomas J. Gould, 2020, Neuropharmacology

The effects of adolescent alcohol exposure on learning and related neurobiology in humans and rodents

Laurel R. Seemiller, Thomas J. Gould, 2020, Neurobiology of Learning and Memory

Stress and nicotine during adolescence disrupts adult hippocampal-dependent learning and alters stress reactivity

Erica D. Holliday, Sheree F. Logue, Chicora Oliver, Debra A. Bangasser, Thomas J. Gould, 2020, Addiction Biology

Cognitive rigidity and BDNF-mediated frontostriatal glutamate neuroadaptations during spontaneous nicotine withdrawal

Robert D. Cole, Matty Zimmerman, Anastasia Matchanova, Munir Gunes Kutlu, Thomas J. Gould, Vinay Parikh, 2020, Neuropsychopharmacology on p. 866-876

Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function

Lisa R. Goldberg, Thomas J. Gould, 2019, European Journal of Neuroscience on p. 2453-2466

Adolescent and adult nicotine exposure differentially impacts oral nicotine and oral saccharin self-administration in mice

Robert D. Cole, Cassandra Wolsh, Matty Zimmerman, Evelynn Harrington, Thomas J. Gould, Vinay Parikh, 2019, Behavioural Brain Research on p. 836-844

Paternal nicotine enhances fear memory, reduces nicotine administration, and alters hippocampal genetic and neural function in offspring

Lisa R. Goldberg, Dana Zeid, Munir Gunes Kutlu, Robert D. Cole, Valeria Lallai, Aswathy Sebastian, Istvan Albert, Christie D. Fowler, Vinay Parikh, Thomas J. Gould, 2019, Addiction Biology

Choline ameliorates adult learning deficits and reverses epigenetic modification of chromatin remodeling factors related to adolescent nicotine exposure

Miri Gitik, Erica D. Holliday, Ming Leung, Qiaoping Yuan, Sheree F. Logue, Roope Tikkanen, David Goldman, Thomas J. Gould, 2018, Neurobiology of Learning and Memory on p. 239-248

Most-Cited Papers

The neural and genetic basis of executive function: Attention, cognitive flexibility, and response inhibition

Sheree F. Logue, Thomas J. Gould, 2014, Pharmacology Biochemistry and Behavior on p. 45-54

Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory

Munir Gunes Kutlu, Thomas J. Gould, 2016, Learning and Memory on p. 515-533

Developmental toxicity of nicotine

Lucinda J. England, Kjersti Aagaard, Michele Bloch, Kevin Conway, Kelly Cosgrove, Rachel Grana, Thomas J. Gould, Dorothy Hatsukami, Frances Jensen, Denise Kandel, Bruce Lanphear, Frances Leslie, James R. Pauly, Jenae Neiderhiser, Mark Rubinstein, Theodore A. Slotkin, Eliot Spindel, Laura Stroud, Lauren Wakschlag, 2017, Neuroscience and Biobehavioral Reviews on p. 176-189

Gadd45b knockout mice exhibit selective deficits in hippocampus-dependent long-term memory

Prescott T. Leach, Shane G. Poplawski, Justin W. Kenney, Barbara Hoffman, Dan A. Liebermann, Ted Abel, Thomas J. Gould, 2012, Learning and Memory on p. 319-324

Developmental effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning

George S. Portugal, Derek S. Wilkinson, Jill R. Turner, Julie A. Blendy, Thomas J. Gould, 2012, Neurobiology of Learning and Memory on p. 482-494

The effects of acute, chronic, and withdrawal from chronic nicotine on novel and spatial object recognition in male C57BL/6J mice

Justin W. Kenney, Michael D. Adoff, Derek S. Wilkinson, Thomas J. Gould, 2011, Psychopharmacology on p. 353-365

Reactivation of cocaine reward memory engages the Akt/GSK3/mTOR signaling pathway and can be disrupted by GSK3 inhibition

Xiangdang Shi, Jonathan S. Miller, Lauren J. Harper, Rachel L. Poole, Thomas J. Gould, Ellen M. Unterwald, 2014, Psychopharmacology on p. 3109-3118

Negative affective states and cognitive impairments in nicotine dependence

F. Scott Hall, Andre Der-Avakian, Thomas J. Gould, Athina Markou, Mohammed Shoaib, Jared W. Young, 2015, Neuroscience and Biobehavioral Reviews on p. 168-185

The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation

Thomas J. Gould, George S. Portugal, Jessica M. André, Matthew P. Tadman, Michael J. Marks, Justin W. Kenney, Emre Yildirim, Michael Adoff, 2012, Neuropharmacology on p. 2118-2125

Targeted deletion of the mouse α2 nicotinic acetylcholine receptor subunit gene (Chrna2) potentiates nicotine-modulated behaviors

Shahrdad Lotfipour, Janet S. Byun, Prescott Leach, Christie D. Fowler, Niall P. Murphy, Paul J. Kenny, Thomas J. Gould, Jim Boulter, 2013, Journal of Neuroscience on p. 7728-7741