Thomas Gould

Jean Phillips Shibley Professor and Department Head of Biobehavioral Health

Thomas Gould

Research Summary

Using genetic, pharmacological, behavioral, and molecular biological techniques to study the neurobiology of learning and memory and the effects of addiction on it.

Huck Affiliations

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Nicotine Memory Fear Learning Hippocampus Rodentia Tobacco Use Disorder Pharmaceutical Preparations Phenotype Inhibition (Psychology) Psychological Inhibition Genes Nicotinic Receptors Anxiety Alcohols Smoking Neoplasms Health Cocaine Maintenance Inbred Strains Mice Epigenomics Data Storage Equipment Inbred C57bl Mouse Alcoholism

Most Recent Publications

Epigenetic and long-term effects of nicotine on biology, behavior, and health

Thomas J. Gould, 2023, Pharmacological Research

Chronic nicotine exposure alters sperm small RNA content in C57BL/6J mouse model

Dana Zeid, Thomas J. Gould, 2023, Developmental Psychobiology

Interstrain differences in adolescent fear conditioning after acute alcohol exposure

Laurel R. Seemiller, Lisa R. Goldberg, Prescilla Garcia-Trevizo, Thomas J. Gould, 2023, Journal of Electrophysiological Techniques on p. 35-44

Adolescent Intermittent Alcohol Exposure Produces Strain-Specific Cross-Sensitization to Nicotine and Other Behavioral Adaptations in Adulthood in C57BL/6J and DBA/2J Mice

Laurel Seemiller, Prescilla Garcia-Trevizo, Carlos Novoa, L Goldberg, Samatha Murray, Thomas Gould, 2023, Pharmacology, Biochemistry and Behavior

Genetic differences in nicotine sensitivity and metabolism in C57BL/6J and NOD/ShiLtJ mouse strains

L Seemiller, L Goldberg, P Smith, J Dennis, A Patterson, Thomas J. Gould, 2022, Neuropharmacology on p. 109279

Genetic influences impacting nicotine use and abuse during adolescence: Insights from human and rodent studies

Lisa R. Goldberg, Thomas J. Gould, 2022, Journal of Electrophysiological Techniques on p. 24-38

Inbred mouse strain differences in alcohol and nicotine addiction-related phenotypes from adolescence to adulthood

Laurel Seemiller, Sheree Logue, Thomas J. Gould, 2022, Pharmacology Biochemistry and Behavior on p. 173429

Balancing Risks and Benefits of E-Cigarettes in the Real World

Joanna E. Cohen, Suchitra Krishnan-Sarin, Thomas Eissenberg, Thomas J. Gould, Micah L. Berman, Aruni Bhatnagar, Tracey E. Barnett, Eric Soule, Lucy Popova, Andy S.L. Tan, Melissa D. Blank, Pamela M. Ling, Richard O'Connor, 2022, American Journal of Public Health on p. E1-E2

The impact of adolescent stress on nicotine use and affective disorders in rodent models

Sean M. Mooney-Leber, Michael *Caruso, Michael J. Caruso, Thomas J. Gould, Sonia A. Cavigelli, Helen M. Kamens, 2022, European Journal of Neuroscience on p. 2196-2215

The Effect of Acute Nicotine Administration on Human Delay Cued and Context Fear Conditioning

Alexandra N. Palmisano, Thomas J. Gould, Robert S. Astur, 2022, Experimental and Clinical Psychopharmacology

Most-Cited Papers

The neural and genetic basis of executive function: Attention, cognitive flexibility, and response inhibition

Sheree F. Logue, Thomas J. Gould, 2014, Pharmacology Biochemistry and Behavior on p. 45-54

Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: Contributions to development and maintenance of addiction

Munir Kutlu, Thomas J. Gould, 2016, Learning and Memory on p. 515-533

Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

James C. Glasbey, Dmitri Nepogodiev, Joana F.F. Simoes, Omar Omar, Elizabeth Li, Mary L. Venn, Mohammad K.Abou Chaar, Vita Capizzi, Daoud Chaudhry, Anant Desai, Jonathan G. Edwards, Jonathan P. Evans, Marco Fiore, Jose Flavio Videria, Samuel J. Ford, Ian Ganly, Ewen A. Griffiths, Rohan R. Gujjuri, Angelos G. Kolias, Haytham M.A. Kaafarani, Ana Minaya-Bravo, Siobhan C. McKay, Helen M. Mohan, Keith J. Roberts, Carlos San Miguel-Méndez, Peter Pockney, Richard Shaw, Neil J. Smart, Grant D. Stewart, Sudha Sundar, Raghavan Vidya, Aneel A. Bhangu, C. Allemand, L. Boccalatte, M. Figari, M. Lamm, J. Larrañaga, C. Marchitelli, F. Noll, D. Odetto, M. Perrotta, J. Saadi, L. Zamora, C. Alurralde, E. L. Caram, D. Eskinazi, J. P. Mendoza, M. Usandivaras, R. Badra, A. Esteban, 2021, Journal of Clinical Oncology on p. 66-78

Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products

Lucinda England, Kjersti Aagaard, Michele Bloch, Kevin Conway, Kelly Cosgrove, Rachel Grana, Thomas J. Gould, Dorothy Hatsukami, Frances Jensen, Denise Kandel, Bruce Lanphear, Frances Leslie, James Pauly, Jenae Neiderhiser, Mark Rubinstein, Theodore Slotkin, Eliot Spindel, Laura Stroud, Lauren Wakschlag, 2017, Neuroscience and Biobehavioral Reviews on p. 176-189

Negative affective states and cognitive impairments in nicotine dependence

F. Scott Hall, Andre Der-Avakian, Thomas J. Gould, Athina Markou, Mohammed Shoaib, Jared W. Young, 2015, Neuroscience and Biobehavioral Reviews on p. 168-185

Nicotine modulation of fear memories and anxiety: Implications for learning and anxiety disorders

Munir Gunes Kutlu, Thomas J. Gould, 2015, Biochemical Pharmacology on p. 498-511

NAChR dysfunction as a common substrate for schizophrenia and comorbid nicotine addiction: Current trends and perspectives

Vinay Parikh, Munir Gunes Kutlu, Thomas J. Gould, 2016, Schizophrenia Research on p. 1-15

Reactivation of cocaine reward memory engages the Akt/GSK3/mTOR signaling pathway and can be disrupted by GSK3 inhibition

Xiangdang Shi, Jonathan S. Miller, Lauren J. Harper, Rachel L. Poole, Thomas J. Gould, Ellen M. Unterwald, 2014, Psychopharmacology on p. 3109-3118

17β-estradiol regulates histone alterations associated with memory consolidation and increases Bdnf promoter acetylation in middle-aged female mice

Ashley M. Fortress, Jaekyoon Kim, Rachel L. Poole, Thomas J. Gould, Karyn M. Frick, 2014, Learning and Memory on p. 457-467

Targeted deletion of the mouse α2 nicotinic acetylcholine receptor subunit gene (Chrna2) potentiates nicotine-modulated behaviors

Shahrdad Lotfipour, Janet S. Byun, Prescott Leach, Christie D. Fowler, Niall P. Murphy, Paul J. Kenny, Thomas J. Gould, Jim Boulter, 2013, Journal of Neuroscience on p. 7728-7741