Thomas Gould
Jean Phillips Shibley Professor and Department Head of Biobehavioral Health

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219 Biobehavioral Health
University Park, PA - tug70@psu.edu
- 814-863-7256
Research Summary
Using genetic, pharmacological, behavioral, and molecular biological techniques to study the neurobiology of learning and memory and the effects of addiction on it.
Huck Affiliations
- Molecular, Cellular, and Integrative Biosciences
- Neuroscience
- Neuroscience Institute
- Center for Molecular Investigation of Neurological Disorders
- Center for Brain, Behavior, and Cognition
- Center for Neurotechnology in Mental Health Research
Links
Publication Tags
Nicotine Fear Memory Hippocampus Anxiety Rodentia Learning Tobacco Use Disorder Inbred Strains Mice Pharmaceutical Preparations Inhibition (Psychology) Psychological Inhibition Genes Nicotinic Receptors Phenotype Genetic Background Cocaine Maintenance Data Storage Equipment Acetylation Alcohol Substance Related Disorders Schizophrenia Inbred Nod Mouse NeoplasmsMost Recent Publications
Chronic nicotine exposure alters sperm small RNA content in C57BL/6J mouse model
Dana Zeid, Thomas Gould, 2023, Developmental Psychobiology
Genetic differences in nicotine sensitivity and metabolism in C57BL/6J and NOD/ShiLtJ mouse strains
Laurel R. Seemiller, Lisa R. Goldberg, Phillip B. Smith, Jason Dennis, Andrew David Patterson, Thomas J. Gould, 2022, Neuropharmacology
Genetic influences impacting nicotine use and abuse during adolescence: Insights from human and rodent studies
Lisa R. Goldberg, Thomas J. Gould, 2022, Journal of Electrophysiological Techniques on p. 24-38
Inbred mouse strain differences in alcohol and nicotine addiction-related phenotypes from adolescence to adulthood
Laurel R. Seemiller, Sheree F. Logue, Thomas J. Gould, 2022, Pharmacology Biochemistry and Behavior
Balancing Risks and Benefits of E-Cigarettes in the Real World
Joanna E. Cohen, Suchitra Krishnan-Sarin, Thomas Eissenberg, Thomas J. Gould, Micah L. Berman, Aruni Bhatnagar, Tracey E. Barnett, Eric Soule, Lucy Popova, Andy S.L. Tan, Melissa D. Blank, Pamela M. Ling, Richard O'Connor, 2022, American Journal of Public Health on p. E1-E2
The impact of adolescent stress on nicotine use and affective disorders in rodent models
Sean M. Mooney-Leber, Michael *Caruso, Michael J. Caruso, Thomas J. Gould, Sonia A. Cavigelli, Helen M. Kamens, 2022, European Journal of Neuroscience on p. 2196-2215
The Effect of Acute Nicotine Administration on Human Delay Cued and Context Fear Conditioning
Alexandra N. Palmisano, Thomas J. Gould, Robert S. Astur, 2022, Experimental and Clinical Psychopharmacology
Genetic Differences in Dorsal Hippocampus Acetylcholinesterase Activity Predict Contextual Fear Learning Across Inbred Mouse Strains
Sean M. Mooney-Leber, Dana Zeid, Prescilla Garcia-Trevizo, Laurel R. Seemiller, Molly A. Bogue, Stephen C. Grubb, Gary Peltz, Thomas J. Gould, 2021, Frontiers in Psychiatry
Genetic background determines behavioral responses during fear conditioning
L. R. Seemiller, S. M. Mooney-Leber, E. Henry, A. McGarvey, A. Druffner, G. Peltz, T. J. Gould, 2021, Communications in behavioral biology. Part A: [Original articles]
Genes and behavior: Animal models
Thomas J. Gould, Lisa R. Goldberg, 2021, on p. 255-262
Most-Cited Papers
The neural and genetic basis of executive function: Attention, cognitive flexibility, and response inhibition
Sheree F. Logue, Thomas J. Gould, 2014, Pharmacology Biochemistry and Behavior on p. 45-54
Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: Contributions to development and maintenance of addiction
Munir Kutlu, Thomas J. Gould, 2016, Learning and Memory on p. 515-533
Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products
Lucinda England, Kjersti Aagaard, Michele Bloch, Kevin Conway, Kelly Cosgrove, Rachel Grana, Thomas J. Gould, Dorothy Hatsukami, Frances Jensen, Denise Kandel, Bruce Lanphear, Frances Leslie, James Pauly, Jenae Neiderhiser, Mark Rubinstein, Theodore Slotkin, Eliot Spindel, Laura Stroud, Lauren Wakschlag, 2017, Neuroscience and Biobehavioral Reviews on p. 176-189
Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study
James C. Glasbey, Dmitri Nepogodiev, Joana F.F. Simoes, Omar Omar, Elizabeth Li, Mary L. Venn, Mohammad K.Abou Chaar, Vita Capizzi, Daoud Chaudhry, Anant Desai, Jonathan G. Edwards, Jonathan P. Evans, Marco Fiore, Jose Flavio Videria, Samuel J. Ford, Ian Ganly, Ewen A. Griffiths, Rohan R. Gujjuri, Angelos G. Kolias, Haytham M.A. Kaafarani, Ana Minaya-Bravo, Siobhan C. McKay, Helen M. Mohan, Keith J. Roberts, Carlos San Miguel-Méndez, Peter Pockney, Richard Shaw, Neil J. Smart, Grant D. Stewart, Sudha Sundar, Raghavan Vidya, Aneel A. Bhangu, C. Allemand, L. Boccalatte, M. Figari, M. Lamm, J. Larrañaga, C. Marchitelli, F. Noll, D. Odetto, M. Perrotta, J. Saadi, L. Zamora, C. Alurralde, E. L. Caram, D. Eskinazi, J. P. Mendoza, M. Usandivaras, R. Badra, A. Esteban, 2021, Journal of Clinical Oncology on p. 66-78
Negative affective states and cognitive impairments in nicotine dependence
F. Scott Hall, Andre Der-Avakian, Thomas J. Gould, Athina Markou, Mohammed Shoaib, Jared W. Young, 2015, Neuroscience and Biobehavioral Reviews on p. 168-185
Reactivation of cocaine reward memory engages the Akt/GSK3/mTOR signaling pathway and can be disrupted by GSK3 inhibition
Xiangdang Shi, Jonathan S. Miller, Lauren J. Harper, Rachel L. Poole, Thomas J. Gould, Ellen M. Unterwald, 2014, Psychopharmacology on p. 3109-3118
Nicotine modulation of fear memories and anxiety: Implications for learning and anxiety disorders
Munir Gunes Kutlu, Thomas J. Gould, 2015, Biochemical Pharmacology on p. 498-511
NAChR dysfunction as a common substrate for schizophrenia and comorbid nicotine addiction: Current trends and perspectives
Vinay Parikh, Munir Gunes Kutlu, Thomas J. Gould, 2016, Schizophrenia Research on p. 1-15
17β-estradiol regulates histone alterations associated with memory consolidation and increases Bdnf promoter acetylation in middle-aged female mice
Ashley M. Fortress, Jaekyoon Kim, Rachel L. Poole, Thomas J. Gould, Karyn M. Frick, 2014, Learning and Memory on p. 457-467
Targeted deletion of the mouse α2 nicotinic acetylcholine receptor subunit gene (Chrna2) potentiates nicotine-modulated behaviors
Shahrdad Lotfipour, Janet S. Byun, Prescott Leach, Christie D. Fowler, Niall P. Murphy, Paul J. Kenny, Thomas J. Gould, Jim Boulter, 2013, Journal of Neuroscience on p. 7728-7741
News Articles Featuring Thomas Gould
Nov 09, 2021
Penn State launches Center for Neurotechnology in Mental Health Research
Penn State is launching a University-wide center to bridge fundamental research to understand the brain and mind with potential clinical applications for diagnosing and treating mental health disorders.
Full Article