Tae-Hee Lee

Professor of Chemistry

Tae-Hee Lee

Research Summary

Single-molecule biophysics of the nucleosome and chromatin

Huck Affiliations

Links

Publication Tags

Nucleosomes Dna Histones Molecules Acetylation Proteins Chromatin Dimers Dna Methylation Deoxyribonucleic Acid Methylation Genes Gene Expression Structural Dynamics Physical Chemistry Rna Polymerase Ii Fluorescence Lysine Kinetics Photolithography Centromere Protein A Protein Binding Centromere Protein C Histone Chaperones Transcription

Most Recent Papers

Physical Chemistry of Epigenetics

Tae Hee Lee, 2019, Journal of Physical Chemistry B on p. 8351-8362

Super-Resolution Optical Lithography with DNA

Shi Ho Kim, Yu Liu, Conner Hoelzel, Xin Zhang, Tae Hee Lee, 2019, Nano letters on p. 6035-6042

How Protein Binding Sensitizes the Nucleosome to Histone H3K56 Acetylation

Jaehyoun Lee, Tae Hee Lee, 2019, ACS chemical biology on p. 506-515

Single-molecule FRET method to investigate the dynamics of transcription elongation through the nucleosome by RNA polymerase II

Jaehyoun Lee, J. Brooks Crickard, Joseph C. Reese, Tae-hee Lee, 2019, Methods

INO80 exchanges H2A.Z for H2A by translocating on DNA proximal to histone dimers

Sandipan Brahma, Maheshi I. Udugama, Jongseong Kim, Arjan Hada, Saurabh K. Bhardwaj, Solomon G. Hailu, Tae Hee Lee, Blaine Bartholomew, 2017, Nature communications

The elongation factor Spt4/5 regulates RNA polymerase II transcription through the nucleosome

John B. Crickard, Jaehyoun Lee, Tae Hee Lee, Joseph C. Reese, 2017, Nucleic acids research on p. 6362-6374

Single-Molecule Investigations on Histone H2A-H2B Dynamics in the Nucleosome

Jaehyoun Lee, Tae Hee Lee, 2017, Biochemistry on p. 977-985

Chromatin structure-dependent conformations of the H1 CTD

He Fang, Sijie Wei, Tae Hee Lee, Jeffrey J. Hayes, 2016, Nucleic acids research on p. 9131-9141

Single-Molecule Observation Reveals Spontaneous Protein Dynamics in the Nucleosome

Jongseong Kim, Sijie Wei, Jaehyoun Lee, Hongjun Yue, Tae-hee Lee, 2016, Journal of Physical Chemistry B on p. 8925-8931

CENP-C directs a structural transition of CENP-A nucleosomes mainly through sliding of DNA gyres

Samantha J. Falk, Jaehyoun Lee, Nikolina Sekulic, Michael A. Sennett, Tae Hee Lee, Ben E. Black, 2016, Nature Structural and Molecular Biology on p. 204-208

Most-Cited Papers

Effects of DNA methylation on the structure of nucleosomes

Ju Yeon Lee, Tae-hee Lee, 2012, Journal of the American Chemical Society on p. 173-175

Sumoylated human histone H4 prevents chromatin compaction by inhibiting long-range internucleosomal interactions

Abhinav Dhall, Sijie Wei, Beat Fierz, Christopher L. Woodcock, Tae Hee Lee, Champak Chatterjee, 2014, Journal of Biological Chemistry on p. 33827-33837

INO80 exchanges H2A.Z for H2A by translocating on DNA proximal to histone dimers

Sandipan Brahma, Maheshi I. Udugama, Jongseong Kim, Arjan Hada, Saurabh K. Bhardwaj, Solomon G. Hailu, Tae Hee Lee, Blaine Bartholomew, 2017, Nature communications

CENP-C directs a structural transition of CENP-A nucleosomes mainly through sliding of DNA gyres

Samantha J. Falk, Jaehyoun Lee, Nikolina Sekulic, Michael A. Sennett, Tae Hee Lee, Ben E. Black, 2016, Nature Structural and Molecular Biology on p. 204-208

Effects of histone acetylation by Piccolo NuA4 on the structure of a nucleosome and the interactions between two nucleosomes

Ju Yeon Lee, Sijie Wei, Tae Hee Lee, 2011, Journal of Biological Chemistry on p. 11099-11109

Dynamics of nucleosome assembly and effects of DNA methylation

Ju Yeon Lee, Jaehyoun Lee, Hongjun Yue, Tae Hee Lee, 2015, Journal of Biological Chemistry on p. 4291-4303

Chromatin structure-dependent conformations of the H1 CTD

He Fang, Sijie Wei, Tae Hee Lee, Jeffrey J. Hayes, 2016, Nucleic acids research on p. 9131-9141

How a holoenzyme for DNA replication is formed

Senthil K. Perumal, Wenhui Ren, Tae Hee Lee, Stephen J. Benkovic, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 99-104

Lysine Acetylation Facilitates Spontaneous DNA Dynamics in the Nucleosome

Jongseong Kim, Jaehyoun Lee, Tae-hee Lee, 2015, Journal of Physical Chemistry B on p. 15001-15005

Single-Molecule Observation Reveals Spontaneous Protein Dynamics in the Nucleosome

Jongseong Kim, Sijie Wei, Jaehyoun Lee, Hongjun Yue, Tae-hee Lee, 2016, Journal of Physical Chemistry B on p. 8925-8931