Tae-Hee Lee
Professor of Chemistry

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Chemistry Bldg
University Park, PA - txl18@psu.edu
- 814-867-2232
Research Summary
Single-molecule biophysics of the nucleosome and chromatin
Huck Affiliations
Links
Publication Tags
Nucleosomes Dna Histones Histone Molecules Acetylation Chromatin Deoxyribonucleic Acid Lysine Proteins Genes Protein Gene Expression Physical Chemistry Dimers Smfret Spectroscopy Modification Dna Methylation Methylation Kinetics Catalysis Photolithography Fragmentation Structural Dynamics DiffractionMost Recent Publications
Conformational dynamics of poly(T) single-stranded DNA at the single-molecule level
Shi Ho Kim, Tae-Hee Lee, the Journal of Physical Chemistry Letters on p. 4576
The Effects of Histone H2B Ubiquitylations on the Nucleosome Structure and Internucleosomal Interactions
Bhaswati Sengupta, Mai Huynh, Charlotte B. Smith, Robert K. McGinty, Wladyslaw Krajewski, Tae Hee Lee, 2022, Biochemistry on p. 2198-2205
DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding
Cathy J. Spangler, Satya P. Yadav, Dongxu Li, Carinne N. Geil, Charlotte B. Smith, Gang Greg Wang, Tae Hee Lee, Robert K. McGinty, 2022, Cell Reports
Enzyme aggregation and fragmentation induced by catalysis relevant species
Kayla Gentile, Ashlesha Bhide, Joshua Kauffman, Subhadip Ghosh, Tae-Hee Lee, Ayusman Sen, Subhabrata Maiti, James Adair, Tae Hee Lee, Ayusman Sen, 2021, Physical Chemistry Chemical Physics on p. 20709-20717
Conformational Dynamics of Poly(T) Single-Stranded DNA at the Single-Molecule Level
Shi Ho Kim, Tae Hee Lee, 2021, Journal of Physical Chemistry Letters on p. 4576-4584
FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices
Eitan Lerner, Anders Barth, Jelle Hendrix, Benjamin Ambrose, Victoria Birkedal, Scott C. Blanchard, Richard Börner, Hoi Sung Chung, Thorben Cordes, Timothy D. Craggs, Ashok A. Deniz, Jiajia Diao, Jingyi Fei, Ruben L. Gonzalez, Irina V. Gopich, Taekjip Ha, Christian A. Hanke, Gilad Haran, Nikos S. Hatzakis, Sungchul Hohng, Seok Cheol Hong, Thorsten Hugel, Antonino Ingargiola, Chirlmin Joo, Achillefs N. Kapanidis, Harold D. Kim, Ted Laurence, Nam Ki Lee, Tae Hee Lee, Edward A. Lemke, Emmanuel Margeat, Jens Michaelis, Xavier Michalet, Sua Myong, Daniel Nettels, Thomas Otavio Peulen, Evelyn Ploetz, Yair Razvag, Nicole C. Robb, Benjamin Schuler, Hamid Soleimaninejad, Chun Tang, Reza Vafabakhsh, Don C. Lamb, Claus A.M. Seidel, Shimon Weiss, Olga Boudker, 2021, eLife
PCNA Monoubiquitination Is Regulated by Diffusion of Rad6/Rad18 Complexes along RPA Filaments
Mingjie Li, Bhaswati Sengupta, Stephen J. Benkovic, Tae Hee Lee, Mark Hedglin, 2020, Biochemistry on p. 4694-4702
Nucleosome Dynamics during Transcription Elongation
Mai Huynh, Satya Yadav, Joseph C. Reese, Tae Hee Lee, 2020, ACS Chemical Biology on p. 3133-3142
Physical Chemistry of Epigenetics: Single-Molecule Investigations
Tae Hee Lee, 2019, Journal of Physical Chemistry B on p. 8351-8362
Super-Resolution Optical Lithography with DNA
Shi Ho Kim, Yu Liu, Conner Hoelzel, Xin Zhang, Tae Hee Lee, 2019, Nano Letters on p. 6035-6042
Most-Cited Papers
INO80 exchanges H2A.Z for H2A by translocating on DNA proximal to histone dimers
Sandipan Brahma, Maheshi I. Udugama, Jongseong Kim, Arjan Hada, Saurabh K. Bhardwaj, Solomon G. Hailu, Tae Hee Lee, Blaine Bartholomew, 2017, Nature Communications
Sumoylated human histone H4 prevents chromatin compaction by inhibiting long-range internucleosomal interactions
Abhinav Dhall, Sijie Wei, Beat Fierz, Christopher L. Woodcock, Tae Hee Lee, Champak Chatterjee, 2014, Journal of Biological Chemistry on p. 33827-33837
FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices
Eitan Lerner, Anders Barth, Jelle Hendrix, Benjamin Ambrose, Victoria Birkedal, Scott C. Blanchard, Richard Börner, Hoi Sung Chung, Thorben Cordes, Timothy D. Craggs, Ashok A. Deniz, Jiajia Diao, Jingyi Fei, Ruben L. Gonzalez, Irina V. Gopich, Taekjip Ha, Christian A. Hanke, Gilad Haran, Nikos S. Hatzakis, Sungchul Hohng, Seok Cheol Hong, Thorsten Hugel, Antonino Ingargiola, Chirlmin Joo, Achillefs N. Kapanidis, Harold D. Kim, Ted Laurence, Nam Ki Lee, Tae Hee Lee, Edward A. Lemke, Emmanuel Margeat, Jens Michaelis, Xavier Michalet, Sua Myong, Daniel Nettels, Thomas Otavio Peulen, Evelyn Ploetz, Yair Razvag, Nicole C. Robb, Benjamin Schuler, Hamid Soleimaninejad, Chun Tang, Reza Vafabakhsh, Don C. Lamb, Claus A.M. Seidel, Shimon Weiss, Olga Boudker, 2021, eLife
CENP-C directs a structural transition of CENP-A nucleosomes mainly through sliding of DNA gyres
Samantha J. Falk, Jaehyoun Lee, Nikolina Sekulic, Michael A. Sennett, Tae Hee Lee, Ben E. Black, 2016, Nature Structural Biology on p. 204-208
A novel hybrid single molecule approach reveals spontaneous DNA motion in the nucleosome
Sijie Wei, Samantha J. Falk, Ben E. Black, Tae Hee Lee, 2015, Nucleic Acids Research
The elongation factor Spt4/5 regulates RNA polymerase II transcription through the nucleosome
John B. Crickard, Jaehyoun Lee, Tae Hee Lee, Joseph C. Reese, 2017, Nucleic Acids Research on p. 6362-6374
Dynamics of nucleosome assembly and effects of DNA methylation
Ju Yeon Lee, Jaehyoun Lee, Hongjun Yue, Tae Hee Lee, 2015, Journal of Biological Chemistry on p. 4291-4303
Chromatin structure-dependent conformations of the H1 CTD
He Fang, Sijie Wei, Tae Hee Lee, Jeffrey J. Hayes, 2016, Nucleic Acids Research on p. 9131-9141
Lysine Acetylation Facilitates Spontaneous DNA Dynamics in the Nucleosome
Jongseong Kim, Jaehyoun Lee, Tae Hee Lee, 2015, Journal of Physical Chemistry B on p. 15001-15005
Single-Molecule Investigations on Histone H2A-H2B Dynamics in the Nucleosome
Jaehyoun Lee, Tae Hee Lee, 2017, Biochemistry on p. 977-985