Tae-Hee Lee

Professor of Chemistry

Tae-Hee Lee

Research Summary

Single-molecule biophysics of the nucleosome and chromatin

Huck Affiliations

Links

Publication Tags

Nucleosomes Dna Histones Chromatin Histone Acetylation Molecules Methylation Dna Methylation Genes Deoxyribonucleic Acid Rna Polymerase Ii Modification Gene Expression Dimers Proteins Protein Physical Chemistry Transcription Fluorescence Elongation Strain Proliferating Cell Nuclear Antigen Surface Replication Protein A

Most Recent Papers

Conformational Dynamics of Poly(T) Single-Stranded DNA at the Single-Molecule Level

Shi Ho Kim, Tae Hee Lee, 2021, Journal of Physical Chemistry Letters on p. 4576-4584

Nucleosome Dynamics during Transcription Elongation

Mai T. Huynh, Satya P. Yadav, Joseph C. Reese, Tae Hee Lee, 2020, ACS Chemical Biology on p. 3133-3142

PCNA Monoubiquitination Is Regulated by Diffusion of Rad6/Rad18 Complexes along RPA Filaments

Mingjie Li, Bhaswati Sengupta, Stephen J. Benkovic, Tae Hee Lee, Mark Hedglin, 2020, Biochemistry on p. 4694-4702

Physical Chemistry of Epigenetics

Tae Hee Lee, 2019, Journal of Physical Chemistry B on p. 8351-8362

Super-resolution optical lithography with DNA

Shi Ho Kim, Yu Liu, Conner Hoelzel, Xin Zhang, Tae Hee Lee, 2019, Nano Letters on p. 6035-6042

Single-molecule FRET method to investigate the dynamics of transcription elongation through the nucleosome by RNA polymerase II

Jaehyoun Lee, J. Brooks Crickard, Joseph C. Reese, Tae Hee Lee, 2019, ImmunoMethods on p. 51-58

How protein binding sensitizes the nucleosome to histone H3K56 acetylation

Jaehyoun Lee, Tae Hee Lee, 2019, ACS Chemical Biology on p. 506-515

Single-molecule fluorescence method to investigate the dynamics of transcription elongation by RNA polymerase II through the nucleosome

J Lee, J Crickard, Joseph Reese, Tae-Hee Lee, 2019, Methods

INO80 exchanges H2A.Z for H2A by translocating on DNA proximal to histone dimers

Sandipan Brahma, Maheshi I. Udugama, Jongseong Kim, Arjan Hada, Saurabh K. Bhardwaj, Solomon G. Hailu, Tae Hee Lee, Blaine Bartholomew, 2017, Nature Communications

The elongation factor Spt4/5 regulates RNA polymerase II transcription through the nucleosome

John B. Crickard, Jaehyoun Lee, Tae Hee Lee, Joseph C. Reese, 2017, Nucleic Acids Research on p. 6362-6374

Most-Cited Papers

Effects of DNA methylation on the structure of nucleosomes

Ju Yeon Lee, Tae Hee Lee, 2012, Journal of the American Chemical Society on p. 173-175

INO80 exchanges H2A.Z for H2A by translocating on DNA proximal to histone dimers

Sandipan Brahma, Maheshi I. Udugama, Jongseong Kim, Arjan Hada, Saurabh K. Bhardwaj, Solomon G. Hailu, Tae Hee Lee, Blaine Bartholomew, 2017, Nature Communications

Sumoylated human histone H4 prevents chromatin compaction by inhibiting long-range internucleosomal interactions

Abhinav Dhall, Sijie Wei, Beat Fierz, Christopher L. Woodcock, Tae Hee Lee, Champak Chatterjee, 2014, Journal of Biological Chemistry on p. 33827-33837

CENP-C directs a structural transition of CENP-A nucleosomes mainly through sliding of DNA gyres

Samantha J. Falk, Jaehyoun Lee, Nikolina Sekulic, Michael A. Sennett, Tae Hee Lee, Ben E. Black, 2016, Nature Structural Biology on p. 204-208

A novel hybrid single molecule approach reveals spontaneous DNA motion in the nucleosome

Sijie Wei, Samantha J. Falk, Ben E. Black, Tae Hee Lee, 2015, Nucleic Acids Research

Dynamics of nucleosome assembly and effects of DNA methylation

Ju Yeon Lee, Jaehyoun Lee, Hongjun Yue, Tae Hee Lee, 2015, Journal of Biological Chemistry on p. 4291-4303

Effects of histone acetylation by Piccolo NuA4 on the structure of a nucleosome and the interactions between two nucleosomes

Ju Yeon Lee, Sijie Wei, Tae Hee Lee, 2011, Journal of Biological Chemistry on p. 11099-11109

Effects of histone acetylation and CpG methylation on the structure of nucleosomes

Ju Yeon Lee, Tae Hee Lee, 2012, BBA - Protein Structure on p. 974-982

The elongation factor Spt4/5 regulates RNA polymerase II transcription through the nucleosome

John B. Crickard, Jaehyoun Lee, Tae Hee Lee, Joseph C. Reese, 2017, Nucleic Acids Research on p. 6362-6374

Chromatin structure-dependent conformations of the H1 CTD

He Fang, Sijie Wei, Tae Hee Lee, Jeffrey J. Hayes, 2016, Nucleic Acids Research on p. 9131-9141