Tae-Hee Lee

Professor of Chemistry

Tae-Hee Lee

Research Summary

Single-molecule biophysics of the nucleosome and chromatin

Huck Affiliations

Links

Publication Tags

Nucleosomes Dna Histones Histone Molecules Acetylation Chromatin Deoxyribonucleic Acid Lysine Proteins Genes Protein Gene Expression Physical Chemistry Dimers Smfret Spectroscopy Modification Dna Methylation Methylation Kinetics Catalysis Photolithography Fragmentation Structural Dynamics Diffraction

Most Recent Publications

Conformational dynamics of poly(T) single-stranded DNA at the single-molecule level

Shi Ho Kim, Tae-Hee Lee, the Journal of Physical Chemistry Letters on p. 4576

The Effects of Histone H2B Ubiquitylations on the Nucleosome Structure and Internucleosomal Interactions

Bhaswati Sengupta, Mai Huynh, Charlotte B. Smith, Robert K. McGinty, Wladyslaw Krajewski, Tae Hee Lee, 2022, Biochemistry on p. 2198-2205

DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding

Cathy J. Spangler, Satya P. Yadav, Dongxu Li, Carinne N. Geil, Charlotte B. Smith, Gang Greg Wang, Tae Hee Lee, Robert K. McGinty, 2022, Cell Reports

Enzyme aggregation and fragmentation induced by catalysis relevant species

Kayla Gentile, Ashlesha Bhide, Joshua Kauffman, Subhadip Ghosh, Tae-Hee Lee, Ayusman Sen, Subhabrata Maiti, James Adair, Tae Hee Lee, Ayusman Sen, 2021, Physical Chemistry Chemical Physics on p. 20709-20717

Conformational Dynamics of Poly(T) Single-Stranded DNA at the Single-Molecule Level

Shi Ho Kim, Tae Hee Lee, 2021, Journal of Physical Chemistry Letters on p. 4576-4584

FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices

Eitan Lerner, Anders Barth, Jelle Hendrix, Benjamin Ambrose, Victoria Birkedal, Scott C. Blanchard, Richard Börner, Hoi Sung Chung, Thorben Cordes, Timothy D. Craggs, Ashok A. Deniz, Jiajia Diao, Jingyi Fei, Ruben L. Gonzalez, Irina V. Gopich, Taekjip Ha, Christian A. Hanke, Gilad Haran, Nikos S. Hatzakis, Sungchul Hohng, Seok Cheol Hong, Thorsten Hugel, Antonino Ingargiola, Chirlmin Joo, Achillefs N. Kapanidis, Harold D. Kim, Ted Laurence, Nam Ki Lee, Tae Hee Lee, Edward A. Lemke, Emmanuel Margeat, Jens Michaelis, Xavier Michalet, Sua Myong, Daniel Nettels, Thomas Otavio Peulen, Evelyn Ploetz, Yair Razvag, Nicole C. Robb, Benjamin Schuler, Hamid Soleimaninejad, Chun Tang, Reza Vafabakhsh, Don C. Lamb, Claus A.M. Seidel, Shimon Weiss, Olga Boudker, 2021, eLife

PCNA Monoubiquitination Is Regulated by Diffusion of Rad6/Rad18 Complexes along RPA Filaments

Mingjie Li, Bhaswati Sengupta, Stephen J. Benkovic, Tae Hee Lee, Mark Hedglin, 2020, Biochemistry on p. 4694-4702

Nucleosome Dynamics during Transcription Elongation

Mai Huynh, Satya Yadav, Joseph C. Reese, Tae Hee Lee, 2020, ACS Chemical Biology on p. 3133-3142

Physical Chemistry of Epigenetics: Single-Molecule Investigations

Tae Hee Lee, 2019, Journal of Physical Chemistry B on p. 8351-8362

Super-Resolution Optical Lithography with DNA

Shi Ho Kim, Yu Liu, Conner Hoelzel, Xin Zhang, Tae Hee Lee, 2019, Nano Letters on p. 6035-6042

Most-Cited Papers

INO80 exchanges H2A.Z for H2A by translocating on DNA proximal to histone dimers

Sandipan Brahma, Maheshi I. Udugama, Jongseong Kim, Arjan Hada, Saurabh K. Bhardwaj, Solomon G. Hailu, Tae Hee Lee, Blaine Bartholomew, 2017, Nature Communications

Sumoylated human histone H4 prevents chromatin compaction by inhibiting long-range internucleosomal interactions

Abhinav Dhall, Sijie Wei, Beat Fierz, Christopher L. Woodcock, Tae Hee Lee, Champak Chatterjee, 2014, Journal of Biological Chemistry on p. 33827-33837

FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices

Eitan Lerner, Anders Barth, Jelle Hendrix, Benjamin Ambrose, Victoria Birkedal, Scott C. Blanchard, Richard Börner, Hoi Sung Chung, Thorben Cordes, Timothy D. Craggs, Ashok A. Deniz, Jiajia Diao, Jingyi Fei, Ruben L. Gonzalez, Irina V. Gopich, Taekjip Ha, Christian A. Hanke, Gilad Haran, Nikos S. Hatzakis, Sungchul Hohng, Seok Cheol Hong, Thorsten Hugel, Antonino Ingargiola, Chirlmin Joo, Achillefs N. Kapanidis, Harold D. Kim, Ted Laurence, Nam Ki Lee, Tae Hee Lee, Edward A. Lemke, Emmanuel Margeat, Jens Michaelis, Xavier Michalet, Sua Myong, Daniel Nettels, Thomas Otavio Peulen, Evelyn Ploetz, Yair Razvag, Nicole C. Robb, Benjamin Schuler, Hamid Soleimaninejad, Chun Tang, Reza Vafabakhsh, Don C. Lamb, Claus A.M. Seidel, Shimon Weiss, Olga Boudker, 2021, eLife

CENP-C directs a structural transition of CENP-A nucleosomes mainly through sliding of DNA gyres

Samantha J. Falk, Jaehyoun Lee, Nikolina Sekulic, Michael A. Sennett, Tae Hee Lee, Ben E. Black, 2016, Nature Structural Biology on p. 204-208

A novel hybrid single molecule approach reveals spontaneous DNA motion in the nucleosome

Sijie Wei, Samantha J. Falk, Ben E. Black, Tae Hee Lee, 2015, Nucleic Acids Research

The elongation factor Spt4/5 regulates RNA polymerase II transcription through the nucleosome

John B. Crickard, Jaehyoun Lee, Tae Hee Lee, Joseph C. Reese, 2017, Nucleic Acids Research on p. 6362-6374

Dynamics of nucleosome assembly and effects of DNA methylation

Ju Yeon Lee, Jaehyoun Lee, Hongjun Yue, Tae Hee Lee, 2015, Journal of Biological Chemistry on p. 4291-4303

Chromatin structure-dependent conformations of the H1 CTD

He Fang, Sijie Wei, Tae Hee Lee, Jeffrey J. Hayes, 2016, Nucleic Acids Research on p. 9131-9141

Lysine Acetylation Facilitates Spontaneous DNA Dynamics in the Nucleosome

Jongseong Kim, Jaehyoun Lee, Tae Hee Lee, 2015, Journal of Physical Chemistry B on p. 15001-15005

Single-Molecule Investigations on Histone H2A-H2B Dynamics in the Nucleosome

Jaehyoun Lee, Tae Hee Lee, 2017, Biochemistry on p. 977-985