Tae-Hee Lee

Professor of Chemistry

Chemistry Bldg
University Park, PA
txl18@psu.edu
814-867-2232

Bio & Links
Publications

Research Summary

Single-molecule biophysics of the nucleosome and chromatin

Huck Affiliations

Molecular, Cellular, and Integrative Biosciences

Publication Tags

These publication tags are generated from the output of this researcher. Click any tag below to view other Huck researchers working on the same topic.

Nucleosomes Dna Histones Histone Proteins Molecules Chromatin Acetylation Lysine Deoxyribonucleic Acid Protein Dimers Smfret Spectroscopy Genes Catalysis Fragmentation Dna Methylation Methylation Kinetics Modification Documentation Structural Dynamics Ubiquitin Ubiquitination Single Stranded Dna

Most Recent Publications

Conformational dynamics of poly(T) single-stranded DNA at the single-molecule level

Shi Ho Kim, Tae-Hee Lee, the Journal of Physical Chemistry Letters on p. 4576

Histone H3 Tail Modifications Alter Structure and Dynamics of the H1 C-Terminal Domain Within Nucleosomes

Subhra Kanti Das, Ashok Kumar, Fanfan Hao, Amber R. Cutter DiPiazza, He Fang, Tae Hee Lee, Jeffrey J. Hayes, 2023, Journal of Molecular Biology

Spontaneous histone exchange between nucleosomes

Subhra Kanti Das, Mai Thao Huynh, Tae Hee Lee, 2023, Journal of Biological Chemistry

Methods to investigate nucleosome structure and dynamics with single-molecule FRET

Subhra K. Das, Mai T. Huynh, Jia Gao, Bhaswati Sengupta, Satya P. Yadav, Tae Hee Lee, 2023, ImmunoMethods on p. 17-27

Effects of Histone H2B Ubiquitylations and H3K79me<sub>3</sub> on Transcription Elongation

Mai T. Huynh, Bhaswati Sengupta, Wladyslaw A. Krajewski, Tae Hee Lee, 2023, ACS Chemical Biology on p. 537-548

The Effects of Histone H2B Ubiquitylations on the Nucleosome Structure and Internucleosomal Interactions

Bhaswati Sengupta, Mai Huynh, Charlotte B. Smith, Robert K. McGinty, Wladyslaw Krajewski, Tae Hee Lee, 2022, Biochemistry on p. 2198-2205

DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding

Cathy J. Spangler, Satya P. Yadav, Dongxu Li, Carinne N. Geil, Charlotte B. Smith, Gang Greg Wang, Tae Hee Lee, Robert K. McGinty, 2022, Cell Reports

Enzyme aggregation and fragmentation induced by catalysis relevant species

Kayla Gentile, Ashlesha Bhide, Joshua Kauffman, Subhadip Ghosh, Tae-Hee Lee, Ayusman Sen, Subhabrata Maiti, James Adair, Tae Hee Lee, Ayusman Sen, 2021, Physical Chemistry Chemical Physics on p. 20709-20717

Conformational Dynamics of Poly(T) Single-Stranded DNA at the Single-Molecule Level

Shi Ho Kim, Tae Hee Lee, 2021, Journal of Physical Chemistry Letters on p. 4576-4584

FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices

Eitan Lerner, Anders Barth, Jelle Hendrix, Benjamin Ambrose, Victoria Birkedal, Scott C. Blanchard, Richard Börner, Hoi Sung Chung, Thorben Cordes, Timothy D. Craggs, Ashok A. Deniz, Jiajia Diao, Jingyi Fei, Ruben L. Gonzalez, Irina V. Gopich, Taekjip Ha, Christian A. Hanke, Gilad Haran, Nikos S. Hatzakis, Sungchul Hohng, Seok Cheol Hong, Thorsten Hugel, Antonino Ingargiola, Chirlmin Joo, Achillefs N. Kapanidis, Harold D. Kim, Ted Laurence, Nam Ki Lee, Tae Hee Lee, Edward A. Lemke, Emmanuel Margeat, Jens Michaelis, Xavier Michalet, Sua Myong, Daniel Nettels, Thomas Otavio Peulen, Evelyn Ploetz, Yair Razvag, Nicole C. Robb, Benjamin Schuler, Hamid Soleimaninejad, Chun Tang, Reza Vafabakhsh, Don C. Lamb, Claus A.M. Seidel, Shimon Weiss, Olga Boudker, 2021, eLife

Tae-Hee Lee

Professor of Chemistry

Research Summary

Huck Affiliations

Links

Publication Tags

Most Recent Publications

Conformational dynamics of poly(T) single-stranded DNA at the single-molecule level

Histone H3 Tail Modifications Alter Structure and Dynamics of the H1 C-Terminal Domain Within Nucleosomes

Spontaneous histone exchange between nucleosomes

Methods to investigate nucleosome structure and dynamics with single-molecule FRET

Effects of Histone H2B Ubiquitylations and H3K79me<sub>3</sub> on Transcription Elongation

The Effects of Histone H2B Ubiquitylations on the Nucleosome Structure and Internucleosomal Interactions

DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding

Enzyme aggregation and fragmentation induced by catalysis relevant species

Conformational Dynamics of Poly(T) Single-Stranded DNA at the Single-Molecule Level

FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices

Most-Cited Papers

FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices

INO80 exchanges H2A.Z for H2A by translocating on DNA proximal to histone dimers

Sumoylated human histone H4 prevents chromatin compaction by inhibiting long-range internucleosomal interactions

CENP-C directs a structural transition of CENP-A nucleosomes mainly through sliding of DNA gyres

A novel hybrid single molecule approach reveals spontaneous DNA motion in the nucleosome

The elongation factor Spt4/5 regulates RNA polymerase II transcription through the nucleosome

Dynamics of nucleosome assembly and effects of DNA methylation

Lysine Acetylation Facilitates Spontaneous DNA Dynamics in the Nucleosome

Chromatin structure-dependent conformations of the H1 CTD

Single-Molecule Observation Reveals Spontaneous Protein Dynamics in the Nucleosome