Seth Bordenstein
Director of the Microbiome Center; Huck Chair in Microbiome Sciences; Professor of Biology and Entomology
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W251 Millennium Science Complex
University Park, PA - srb6251@psu.edu
Research Summary
The evolutionary and genetic principles that shape symbiotic interactions between animals, microbes, and viruses and the major applications of these interactions to human health.
Huck Affiliations
Links
Publication Tags
Microbiota Microbiome Animals Symbiosis Genome Microorganisms Weight Gastrointestinal Microbiome Biological Sciences Diet Wolbachia Proteins Glucose Wasps Nasonia Drosophila Melanogaster Viruses Spermatozoa Cytoplasmic Incompatibility History Molecular Cluster Nationalities And Ethnic Groups Protein Prophages MetabolicMost Recent Publications
Transgenic cytoplasmic incompatibility persists across age and temperature variation in Drosophila melanogaster
Isabella T. Ritchie, Kelly T. Needles, Brittany A. Leigh, Rupinder Kaur, Seth R. Bordenstein, 2022, iScience
Individuality and ethnicity eclipse a short-term dietary intervention in shaping microbiomes and viromes
Junhui Li, Robert H.George Markowitz, Andrew W. Brooks, Elizabeth K. Mallott, Brittany A. Leigh, Timothy Olszewski, Hamid Zare, Minoo Bagheri, Holly M. Smith, Katie A. Friese, Ismail Habibi, William M. Lawrence, Charlie L. Rost, Ákos Lédeczi, Angela M. Eeds, Jane F. Ferguson, Heidi J. Silver, Seth R. Bordenstein, 2022, PLoS Biology
Microbiome-associated human genetic variants impact phenome-wide disease risk
Robert H.George Markowitz, Abigail Leavitt LaBella, Mingjian Shi, Antonis Rokas, John A. Capra, Jane F. Ferguson, Jonathan D. Mosley, Seth R. Bordenstein, 2022, Proceedings of the National Academy of Sciences of the United States of America
The Cif proteins from Wolbachia prophage WO modify sperm genome integrity to establish cytoplasmic incompatibility
Rupinder Kaur, Brittany A. Leigh, Isabella T. Ritchie, Seth R. Bordenstein, 2022, PLoS Biology
A Margulian View of Symbiosis and Speciation: the Nasonia Wasp System
Kara Bell, Seth R. Bordenstein, 2022, Symbiosis on p. 3-10
Comparison of qPCR and dPCR methods for the quantification of Wolbachia densities and arthropod gene expression.
K.L. Cross, Seth Bordenstein, 2022, Qiagen Application Note
Widespread phages of endosymbionts: Phage WO genomics and the proposed taxonomic classification of Symbioviridae
Sarah Bordenstein, Seth R. Bordenstein, 2022, PLoS Genetics on p. e1010227
A single synonymous nucleotide change impacts the male-killing phenotype of prophage wo gene wmk
Jessamyn I. Perlmutter, Jane E. Meyers, Seth R. Bordenstein, 2021, eLife
The microbiome impacts host hybridization and speciation
Asia K. Miller, Camille S. Westlake, Karissa L. Cross, Brittany A. Leigh, Seth R. Bordenstein, 2021, PLoS Biology
New-onset vegetarian diet shows differences in fatty acid metabolites in European American and African American women
Naomi C. Wang, Minoo Bagheri, Timothy Olszewski, Katie A. Friese, Holly M. Smith, Michelle E. Robles, Chuan Wang, Andrew Brooks, Seth R. Bordenstein, Jane F. Ferguson, Heidi J. Silver, 2021, Nutrition, Metabolism and Cardiovascular Diseases on p. 2436-2448
Most-Cited Papers
Host biology in light of the microbiome: Ten principles of holobionts and hologenomes
Seth R. Bordenstein, Kevin R. Theis, 2015, PLoS Biology
Mom Knows Best: The Universality of Maternal Microbial Transmission
Lisa J. Funkhouser, Seth R. Bordenstein, 2013, PLoS Biology
Phylosymbiosis: Relationships and Functional Effects of Microbial Communities across Host Evolutionary History
Andrew W. Brooks, Kevin D. Kohl, Robert M. Brucker, Edward J. van Opstal, Seth R. Bordenstein, 2016, PLoS Biology
Getting the hologenome concept right: An eco-evolutionary framework for hosts and their microbiomes
Kevin R. Theis, Nolwenn M. Dheilly, Jonathan L. Klassen, Robert M. Brucker, John F. Baines, Thomas C.G. Bosch, John F. Cryan, Scott F. Gilbert, Charles J. Goodnight, Elisabeth A. Lloyd, Jan Sapp, Philippe Vandenkoornhuyse, Ilana Zilber-Rosenberg, Eugene Rosenberg, Seth R. Bordenstein, 2016, mSystems
The hologenomic basis of speciation: Gut bacteria cause hybrid lethality in the genus Nasonia
Robert Brucker, Seth R. Bordenstein, 2013, Science on p. 667-669
Prophage WO genes recapitulate and enhance Wolbachia-induced cytoplasmic incompatibility
Daniel LePage, Daniel P. Le Page, Jason Metcalf, Sarah Bordenstein, Jungmin On, Jessamyn Perlmutter, J Shropshire, Emily Layton, Lisa Funkhouser-Jones, John Beckmann, Seth R. Bordenstein, 2017, Nature on p. 243--247
Minimum information about an uncultivated virus genome (MIUVIG)
Simon Roux, Evelien M. Adriaenssens, Bas E. Dutilh, Eugene V. Koonin, Andrew M. Kropinski, Mart Krupovic, Jens H. Kuhn, Rob Lavigne, J. Rodney Brister, Arvind Varsani, Clara Amid, Ramy K. Aziz, Seth R. Bordenstein, Peer Bork, Mya Breitbart, Guy R. Cochrane, Rebecca A. Daly, Christelle Desnues, Melissa B. Duhaime, Joanne B. Emerson, François Enault, Jed A. Fuhrman, Pascal Hingamp, Philip Hugenholtz, Bonnie L. Hurwitz, Natalia N. Ivanova, Jessica M. Labonté, Kyung Bum Lee, Rex R. Malmstrom, Manuel Martinez-Garcia, Ilene Karsch Mizrachi, Hiroyuki Ogata, David Páez-Espino, Marie Agnès Petit, Catherine Putonti, Thomas Rattei, Alejandro Reyes, Francisco Rodriguez-Valera, Karyna Rosario, Lynn Schriml, Frederik Schulz, Grieg F. Steward, Matthew B. Sullivan, Shinichi Sunagawa, Curtis A. Suttle, Ben Temperton, Susannah G. Tringe, Rebecca Vega Thurber, Nicole S. Webster, Katrine L. Whiteson, Steven W. Wilhelm, K. Eric Wommack, Tanja Woyke, Kelly C. Wrighton, Pelin Yilmaz, Takashi Yoshida, Mark J. Young, Natalya Yutin, Lisa Zeigler Allen, Nikos C. Kyrpides, Emiley A. Eloe-Fadrosh, 2019, Nature Biotechnology on p. 29-37
Microbiota and the social brain
Eoin Sherwin, Seth R. Bordenstein, John L. Quinn, Timothy G. Dinan, John F. Cryan, 2019, Science
Gut microbiota diversity across ethnicities in the United States
Andrew W. Brooks, Sambhawa Priya, Ran Blekhman, Seth R. Bordenstein, 2018, PLoS Biology
Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery
Charles Robb Flynn, Vance L. Albaugh, Steven Cai, Joyce Cheung-Flynn, Phillip E. Williams, Robert M. Brucker, Seth R. Bordenstein, Yan Guo, David H. Wasserman, Naji N. Abumrad, 2015, Nature Communications
News Articles Featuring Seth Bordenstein
Mar 07, 2023
Habitat split may impact disease risk in amphibians and other vertebrates
Habitat split is a common event in the environment that occurs when different classes of natural habitats, such as forests and water, are disconnected.
Full Article
Feb 27, 2023
New predictive models developed for bacterial diversity of soils
A new set of quantitative models that incorporates pH into the metabolic theory of ecology (MTE) has been developed by an international team that includes Penn State assistant professor of plant science Francisco Dini-Andreote.
Full Article
Feb 15, 2023
Free film and panel discussion reveals 'invisible' crisis of the microbial world
At 6 p.m. Thursday, March 2, Penn State’s Microbiome Center will present "The Invisible Extinction" — a movie that spotlights the trailblazing work and charismatic personalities of renowned scientists who aim to save the vanishing microbes that are essential for our survival.
Full Article
Dec 22, 2022
2022 Top 10 Most Popular Microbiome Center News Articles
The stories that made the year in 2022 for the Penn State Microbiome Center
Full Article
Sep 13, 2022
Microbiome Center announces inaugural Interdisciplinary Innovation Fellows
The Penn State Microbiome Center has named six recipients for its inaugural Interdisciplinary Innovation Fellowships (IIF) program, which aims to promote collaborative training opportunities for center members.
Full Article