Seth Bordenstein
Director of the Microbiome Center; Huck Chair in Microbiome Sciences; Professor of Biology and Entomology
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W251 Millennium Science Complex
University Park, PA - srb6251@psu.edu
Research Summary
The evolutionary and genetic principles that shape symbiotic interactions between animals, microbes, and viruses and the major applications of these interactions to human health.
Huck Affiliations
- One Health Microbiome Center
- Molecular, Cellular, and Integrative Biosciences
- Bioinformatics and Genomics
Links
Publication Tags
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Microbiota Microbiome Animals Gastrointestinal Microbiome Symbiosis Intestinal Microorganisms Microorganisms Biological Sciences Glucose Wasps Nationalities And Ethnic Groups Fibrosis Molecular Cluster Lizards Metabolic Weight Viruses Microbial Ecology History Diet Digestive System Genes Coevolution Genome FlowMost Recent Publications
The mechanism of cytoplasmic incompatibility is conserved in Wolbachia-bearing Aedes aegypti mosquitoes deployed for arbovirus control
R Kaur, Cole Meier, E McGraw, Julian Hillyer, Seth Bordenstein, 2024, PLOS Biology
Prophage proteins alter long noncoding RNA and DNA of developing sperm to induce a paternal-effect lethality
Rupinder Kaur, Angelina McGarry, J. Dylan Shropshire, Brittany A. Leigh, Seth R. Bordenstein, 2024, Science on p. 1111-1117
It is time to authenticate the Microbiome Sciences with accredited educational programs and departments
Nichole Ginnan, Seth R. Bordenstein, 2023, PLoS Biology
Human microbiome variation associated with race and ethnicity emerges as early as 3 months of age
Elizabeth K. Mallott, Alexandra R. Sitarik, Leslie D. Leve, Camille Cioffi, Carlos A. Camargo, Kohei Hasegawa, Seth R. Bordenstein, 2023, PLoS Biology
Low Gut Microbial Diversity Augments Estrogen-Driven Pulmonary Fibrosis in Female-Predominant Interstitial Lung Disease
Ozioma S. Chioma, Elizabeth Mallott, Binal Shah-Gandhi, Za Darreyal Wiggins, Madison Langford, Andrew William Lancaster, Alexander Gelbard, Hongmei Wu, Joyce E. Johnson, Lisa Lancaster, Erin M. Wilfong, Leslie J. Crofford, Courtney G. Montgomery, Luc Van Kaer, Seth Bordenstein, Dawn C. Newcomb, Wonder Puryear Drake, 2023, Cells
Gut microbiota modulates lung fibrosis severity following acute lung injury in mice
Ozioma S. Chioma, Elizabeth K. Mallott, Austin Chapman, Joseph C. Van Amburg, Hongmei Wu, Binal Shah-Gandhi, Nandita Dey, Marina E. Kirkland, M. Blanca Piazuelo, Joyce Johnson, Gordon R. Bernard, Sobha R. Bodduluri, Steven Davison, Bodduluri Haribabu, Seth R. Bordenstein, Wonder P. Drake, 2022, Communications Biology
Transgenic cytoplasmic incompatibility persists across age and temperature variation in Drosophila melanogaster
Isabella T. Ritchie, Kelly T. Needles, Brittany A. Leigh, Rupinder Kaur, Seth R. Bordenstein, 2022, iScience
Individuality and ethnicity eclipse a short-term dietary intervention in shaping microbiomes and viromes
Junhui Li, Robert H.George Markowitz, Andrew W. Brooks, Elizabeth K. Mallott, Brittany A. Leigh, Timothy Olszewski, Hamid Zare, Minoo Bagheri, Holly M. Smith, Katie A. Friese, Ismail Habibi, William M. Lawrence, Charlie L. Rost, Ákos Lédeczi, Angela M. Eeds, Jane F. Ferguson, Heidi J. Silver, Seth R. Bordenstein, 2022, PLoS Biology
Microbiome-associated human genetic variants impact phenome-wide disease risk
Robert H.George Markowitz, Abigail Leavitt LaBella, Mingjian Shi, Antonis Rokas, John A. Capra, Jane F. Ferguson, Jonathan D. Mosley, Seth R. Bordenstein, 2022, Proceedings of the National Academy of Sciences of the United States of America
A Margulian View of Symbiosis and Speciation: the Nasonia Wasp System
Kara Bell, Seth R. Bordenstein, 2022, Symbiosis on p. 3-10
Most-Cited Papers
Host biology in light of the microbiome: Ten principles of holobionts and hologenomes
Seth R. Bordenstein, Kevin R. Theis, 2015, PLoS Biology
Getting the hologenome concept right: An eco-evolutionary framework for hosts and their microbiomes
Kevin R. Theis, Nolwenn M. Dheilly, Jonathan L. Klassen, Robert M. Brucker, John F. Baines, Thomas C.G. Bosch, John F. Cryan, Scott F. Gilbert, Charles J. Goodnight, Elisabeth A. Lloyd, Jan Sapp, Philippe Vandenkoornhuyse, Ilana Zilber-Rosenberg, Eugene Rosenberg, Seth R. Bordenstein, 2016, mSystems
Phylosymbiosis: Relationships and Functional Effects of Microbial Communities across Host Evolutionary History
Andrew W. Brooks, Kevin D. Kohl, Robert M. Brucker, Edward J. van Opstal, Seth R. Bordenstein, 2016, PLoS Biology
Prophage WO genes recapitulate and enhance Wolbachia-induced cytoplasmic incompatibility
Daniel LePage, Daniel P. Le Page, Jason Metcalf, Sarah Bordenstein, Jungmin On, Jessamyn Perlmutter, J Shropshire, Emily Layton, Lisa Funkhouser-Jones, John Beckmann, Seth R. Bordenstein, 2017, Nature on p. 243--247
Minimum information about an uncultivated virus genome (MIUVIG)
Simon Roux, Evelien M. Adriaenssens, Bas E. Dutilh, Eugene V. Koonin, Andrew M. Kropinski, Mart Krupovic, Jens H. Kuhn, Rob Lavigne, J. Rodney Brister, Arvind Varsani, Clara Amid, Ramy K. Aziz, Seth R. Bordenstein, Peer Bork, Mya Breitbart, Guy R. Cochrane, Rebecca A. Daly, Christelle Desnues, Melissa B. Duhaime, Joanne B. Emerson, François Enault, Jed A. Fuhrman, Pascal Hingamp, Philip Hugenholtz, Bonnie L. Hurwitz, Natalia N. Ivanova, Jessica M. Labonté, Kyung Bum Lee, Rex R. Malmstrom, Manuel Martinez-Garcia, Ilene Karsch Mizrachi, Hiroyuki Ogata, David Páez-Espino, Marie Agnès Petit, Catherine Putonti, Thomas Rattei, Alejandro Reyes, Francisco Rodriguez-Valera, Karyna Rosario, Lynn Schriml, Frederik Schulz, Grieg F. Steward, Matthew B. Sullivan, Shinichi Sunagawa, Curtis A. Suttle, Ben Temperton, Susannah G. Tringe, Rebecca Vega Thurber, Nicole S. Webster, Katrine L. Whiteson, Steven W. Wilhelm, K. Eric Wommack, Tanja Woyke, Kelly C. Wrighton, Pelin Yilmaz, Takashi Yoshida, Mark J. Young, Natalya Yutin, Lisa Zeigler Allen, Nikos C. Kyrpides, Emiley A. Eloe-Fadrosh, 2019, Nature Biotechnology on p. 29-37
Microbiota and the social brain
Eoin Sherwin, Seth R. Bordenstein, John L. Quinn, Timothy G. Dinan, John F. Cryan, 2019, Science
Gut microbiota diversity across ethnicities in the United States
Andrew W. Brooks, Sambhawa Priya, Ran Blekhman, Seth R. Bordenstein, 2018, PLoS Biology
Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery
Charles Robb Flynn, Vance L. Albaugh, Steven Cai, Joyce Cheung-Flynn, Phillip E. Williams, Robert M. Brucker, Seth R. Bordenstein, Yan Guo, David H. Wasserman, Naji N. Abumrad, 2015, Nature Communications
Gut microbial ecology of lizards: insights into diversity in the wild, effects of captivity, variation across gut regions and transmission
Kevin D. Kohl, Antonio Brun, Melisa Magallanes, Joshua Brinkerhoff, Alejandro Laspiur, Juan Carlos Acosta, Enrique Caviedes-Vidal, Seth R. Bordenstein, 2017, Molecular Ecology on p. 1175-1189
An introduction to phylosymbiosis
Shen Jean Lim, Seth R. Bordenstein, 2020, Proceedings of the Royal Society B: Biological Sciences
News Articles Featuring Seth Bordenstein
Mar 08, 2024
Virus hijacking insect sperm causes brutal sterility, find scientists
Penn State researchers unveil the tale of Wolbachia and its viral accomplice manipulating insect reproduction
Full Article
Mar 08, 2024
How does a virus hijack insect sperm to control disease vectors and pests?
A widespread bacteria called Wolbachia and a virus that it carries can cause sterility in male insects by hijacking their sperm, preventing them from fertilizing eggs of females that do not have the same combination of bacteria and virus.
Full Article
Jan 27, 2024
QIAGEN Announces Partnership With Penn State University to Advance Microbiome Sciences
QIAGEN Announces Partnership With Penn State University to Advance Microbiome Sciences
Full Article
Jan 25, 2024
Penn State, QIAGEN announce strategic partnership to advance microbiome sciences
Penn State, known for innovations in interdisciplinary research, and QIAGEN LLC, a leader in sample-to-insight solutions, have signed a memorandum of understanding (MOU) to foster advancements in microbiome sciences
Full Article
Jan 25, 2024
QIAGEN announces partnership with Penn State University to advance microbiome sciences
Qiagen to provide instruments and solutions for shared research and education facility at the One Health Microbiome Center to support faculty and students
Full Article
Jan 25, 2024
QIAGEN announces partnership with Penn State University to advance microbiome sciences
QIAGEN announced a first-in-kind collaboration with Penn State University to create a shared research and education facility for the fast-developing microbiome sciences
Full Article
Jan 25, 2024
Qiagen partners with Penn State to advance microbiome sciences
QIAGEN announced a first-in-kind collaboration with Penn State University to create a shared research and education facility for the fast-developing microbiome sciences
Full Article
Jan 25, 2024
Qiagen Announces Partnership With Penn State University To Advance Microbiome Sciences
Qiagen announces partnership with Penn State University to Advance Microbiome Sciences
Full Article
Dec 08, 2023
Penn State researchers propose a path to authenticate the Microbiome Sciences
Penn State's One Health Microbiome Center is taking a lead role in the promotion of Microbiome Sciences as an autonomous discipline, publishing an editorial in the latest issue of PLOS Biology.
Full Article
Dec 07, 2023
Penn State researchers announce new comprehensive -Omics database
A group of Penn State scientists have announced kmerDB, an extensive catalogue of sequence information representing all domains of life.
Full Article