Sergei Grigoryev

Professor of Biochemistry and Molecular Biology

H171 Biochemistry & Molecular Biology
Hershey, PA
sag17@psu.edu
717-531-8588

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Chromatin Nucleosomes Histones Dna Genes Gene Silencing Single Stranded Dna Genome Histone Chromosomes Heterochromatin Granulocytes Genomic Instability Chromosome Mapping Myeloid Leukemia Cystatin B Double Stranded Dna Breaks Acute Myeloid Leukemia Metaphase Repair Histone Methyltransferase Histone Methyltransferases Genetic Translocation Cell Nucleus Stem Cells

Most Recent Publications

Attraction of Likenesses: Mechanisms of Self-Association and Compartmentalization of Eukaryotic Chromatin

S. A. Grigoryev, E. Y. Popova, 2019, Molekulyarnaya Biologiya on p. 933-953

Attraction of Likenesses: Mechanisms of Self-Association and Compartmentalization of Eukaryotic Chromatin

S. A. Grigoryev, E. Y. Popova, 2019, Molecular Biology on p. 820-837

Nucleosome spacing periodically modulates nucleosome chain folding and DNA topology in circular nucleosome arrays

Mikhail V. Bass, Tatiana Nikitina, Davood Norouzi, Victor B. Zhurkin, Sergei A. Grigoryev, 2019, Journal of Biological Chemistry on p. 4233-4246

Unraveling the multiplex folding of nucleosome chains in higher order chromatin

Sergei A. Grigoryev, Michael Schubert, 2019, Essays in Biochemistry on p. 109-121

Chromatin Higher-Order Folding: A Perspective with Linker DNA Angles

Sergei A. Grigoryev, 2018, Biophysical Journal on p. 2290-2297

Regulation of chromatin folding by conformational variations of nucleosome linker DNA

Jenna M. Buckwalter, Davood Norouzi, Anna Harutyunyan, Victor B. Zhurkin, Sergei A. Grigoryev, 2017, Nucleic Acids Research on p. 9372-9387

Nucleosome-like, single-stranded DNA (ssDNA)-histone octamer complexes and the implication for DNA double strand break repair

Nicholas L. Adkins, Sarah G. Swygert, Parminder Kaur, Hengyao Niu, Sergei A. Grigoryev, Patrick Sung, Hong Wang, Craig L. Peterson, 2017, Journal of Biological Chemistry on p. 5271-5281

Genome-wide mapping of histone H3K9me2 in acute myeloid leukemia reveals large chromosomal domains associated with massive gene silencing and sites of genome instability

Anna C. Salzberg, Abigail Harris-Becker, Evgenya Y. Popova, Nikki Keasey, Thomas P. Loughran, David F. Claxton, Sergei A. Grigoryev, 2017, PLoS One

DNA topology in chromatin is defined by nucleosome spacing

Tatiana Nikitina, Davood Norouzi, Sergei A. Grigoryev, Victor B. Zhurkin, 2017, Science advances

Hierarchical looping of zigzag nucleosome chains in metaphase chromosomes

Sergei A. Grigoryev, Gavin Bascom, Jenna M. Buckwalter, Michael B. Schubert, Christopher L. Woodcock, Tamar Schlick, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 1238-1243

Most-Cited Papers

Hierarchical looping of zigzag nucleosome chains in metaphase chromosomes

Dynamic condensation of linker histone C-terminal domain regulates chromatin structure

Antoni Luque, Rosana Collepardo-Guevara, Sergei Grigoryev, Tamar Schlick, 2014, Nucleic Acids Research on p. 7553-7560

A role for stefin B (cystatin B) in inflammation and endotoxemia

Katarina Maher, Barbara Jerič Kokelj, Miha Butinar, Georgy Mikhaylov, Mateja Manček-Keber, Veronika Stoka, Olga Vasiljeva, Boris Turk, Sergei A. Grigoryev, Natasa Kopitar-Jerala, 2014, Journal of Biological Chemistry on p. 31736-31750

Developmentally regulated linker histone H1c promotes heterochromatin condensation and mediates structural integrity of rod photoreceptors in mouse retina

Evgenya Y. Popova, Sergei A. Grigoryev, Yuhong Fan, Arthur I. Skoultchi, Samuel S. Zhang, Colin J. Barnstable, 2013, Journal of Biological Chemistry on p. 17895-17907

Granulocyte maturation determines ability to release chromatin NETs and loss of DNA damage response; these properties are absent in immature AML granulocytes

Emilie Lukášová, Zdeněk Kořistek, Martin Klabusay, Vladan Ondřej, Sergei Grigoryev, Alena Bačíková, Martina Řezáčová, Martin Falk, Jiřina Vávrová, Viera Kohútová, Stanislav Kozubek, 2013, Biochimica et Biophysica Acta - Molecular Cell Research on p. 767-779