Serena Noss
Graduate Student
Graduate Advisor
Huck Affiliations
News Articles Featuring Serena Noss
May 05, 2026
How can the same genetic mutation lead to different clinical outcomes?
Individuals that share the same deletion of a portion of chromosome 16 are at risk of developing neurodevelopmental disorders, but some experience severe intellectual disability or developmental delay, while others may only exhibit milder psychiatric features like depression or anxiety. How can this be? To answer this, a team led by Penn State scientists has developed methods to evaluate how genetic variants elsewhere in an individual’s genome work with the deletion to help determine the features that the individual will manifest.
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Oct 07, 2025
Background genetic variants influence clinical features in complex disorders
New study reveals how the complex interplay of genetic background can lead to different clinical presentations in individuals that share a primary genetic variant.
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