Robert Paulson
Professor of Veterinary and Biomedical Sciences
-
104 Henning Building
University Park, PA 16802 - rfp5@psu.edu
- 814-863-6306
Research Summary
The Paulson lab studies the mechanisms that regulate tissue regeneration with a focus on understanding the response to anemic and hypoxic stress
Huck Graduate Students
Huck Affiliations
- Integrative and Biomedical Physiology
- Molecular, Cellular, and Integrative Biosciences
- Center for Malaria Research
Links
Publication Tags
Erythropoiesis Macrophages Selenium Erythrocytes Heme Chemical Activation Prostaglandins Stem Cells Inflammation Spleen Selenoproteins Anemia Cyclopentenone Leukemia Ligand Prostaglandins D Prostaglandin Down Regulation Calcium Polymerization Effector Amount Ppar Gamma Erythropoietin Receptors Omega 3 Fatty AcidsMost Recent Papers
A novel clinically relevant graft-versus-leukemia model in humanized mice
Bei Jia, Chenchen Zhao, Michael Bayerl, Hiroko Shike, David F. Claxton, W. Christopher Ehmann, Shin Mineishi, Todd D. Schell, Pan Zheng, Yi Zhang, Leonard D. Shultz, K. Sandeep Prabhu, Robert F. Paulson, Hong Zheng, 2021, Journal of Leukocyte Biology
Development of SKI-349, a dual-targeted inhibitor of sphingosine kinase and microtubule polymerization
Jeremy A. Hengst, Shailaja Hegde, Robert F. Paulson, Jong K. Yun, 2020, Bioorganic and Medicinal Chemistry Letters
Stress erythropoiesis
Robert F. Paulson, Sneha Hariharan, Jane A. Little, 2020, Experimental Hematology on p. 43-54.e2
Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation
Yuanting Chen, Jie Xiang, Fenghua Qian, Bastihalli T. Diwakar, Baiye Ruan, Siyang Hao, K. Sandeep Prabhu, Robert F. Paulson, 2020, Blood on p. 235-246
Stress Erythropoiesis is a Key Inflammatory Response
Robert F. Paulson, Baiye Ruan, Siyang Hao, Yuanting Chen, 2020, Cells
Yap1 promotes proliferation of transiently amplifying stress erythroid progenitors during erythroid regeneration
Siyang Hao, Yurika Matsui, Zhi Chun Lai, Robert F. Paulson, 2019, Experimental Hematology on p. 42-54.e4
Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-αB activation in murine macrophages via changes in intracellular calcium
Bastihalli T. Diwakar, Ryan Yoast, Shaneice Nettleford, Fenghua Qian, Tai Jung Lee, Svanjita Berry, Ian Huffnagle, Randall M. Rossi, Mohamed Trebak, Robert F. Paulson, K. Sandeep Prabhu, 2019, FASEB Journal on p. 12838-12852
Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C
Laura F. Bennett, Chang Liao, Michael D. Quickel, Beng San Yeoh, Matam Vijay-Kumar, Pamela Hankey-Giblin, K. Sandeep Prabhu, Robert F. Paulson, 2019, Science's STKE : signal transduction knowledge environment
Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche
Siyang Hao, Jie Xiang, Dai Chen Wu, James W. Fraser, Baiye Ruan, Jingwei Cai, Andrew D. Patterson, Zhi Chun Lai, Robert F. Paulson, 2019, Blood advances on p. 2205-2217
Downregulation of CD73 associates with T cell exhaustion in AML patients
Yaxian Kong, Bei Jia, Chenchen Zhao, David F. Claxton, Arati Sharma, Charyguly Annageldiyev, Joseph S. Fotos, Hui Zeng, Robert F. Paulson, K. Sandeep Prabhu, Hong Zheng, 2019, Journal of Hematology and Oncology
Most-Cited Papers
Stress erythropoiesis
Robert F. Paulson, Lei Shi, Dai Chen Wu, 2011, Current Opinion in Hematology on p. 139-145
Selenoprotein-dependent up-regulation of hematopoietic prostaglandin D <sub>2</sub> synthase in macrophages is mediated through the activation of Peroxisome Proliferator-activated Receptor (PPAR) γ
Ujjawal H. Gandhi, Naveen Kaushal, Kodihalli C. Ravindra, Shailaja Hegde, Shakira M. Nelson, Vivek Narayan, Hema Vunta, Robert F. Paulson, K. Sandeep Prabhu, 2011, Journal of Biological Chemistry on p. 27471-27482
Δ <sup>12</sup>-prostaglandin J <sub>3</sub>, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice
Shailaja Hegde, Naveen Kaushal, Kodihalli C. Ravindra, Christopher Chiaro, Kelsey T. Hafer, Ujjawal H. Gandhi, Jerry T. Thompson, John P. Van Den Heuvel, Mary J. Kennett, Pamela Hankey, Robert F. Paulson, K. Sandeep Prabhu, 2011, Blood on p. 6909-6919
In vitro culture of stress erythroid progenitors identifies distinct progenitor populations and analogous human progenitors
Jie Xiang, Dai Chen Wu, Yuanting Chen, Robert F. Paulson, 2015, Blood on p. 1803-1812
The regulation of erythropoiesis by selenium in mice
Naveen Kaushal, Shailaja Hegde, Jeanne Lumadue, Robert F. Paulson, K. Sandeep Prabhu, 2011, Antioxidants and Redox Signaling on p. 1403-1412
Monocyte-derived macrophages expand the murine stress erythropoietic niche during the recovery from anemia
Chang Liao, K. Sandeep Prabhu, Robert F. Paulson, 2018, Blood on p. 2580-2593
A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis.
Michael R. Hughes, Nicole Anderson, Steven Maltby, Justin Wong, Zorana Berberovic, Connie S. Birkenmeier, D. James Haddon, Kamal Garcha, Ann Flenniken, Lucy R. Osborne, S. Lee Adamson, Janet Rossant, Luanne L. Peters, Mark D. Minden, Robert F. Paulson, Chen Wang, Dwayne L. Barber, Kelly M. McNagny, William L. Stanford, 2011, Experimental Hematology on p. 601-611
Targeting a new regulator of erythropoiesis to alleviate anemia
Robert F. Paulson, 2014, Nature Medicine on p. 334-335
Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis
Chang Liao, Ross C. Hardison, Mary J. Kennett, Bradley A. Carlson, Robert F. Paulson, K. Sandeep Prabhu, 2018, Blood on p. 2568-2580
Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C
Laura F. Bennett, Chang Liao, Michael D. Quickel, Beng San Yeoh, Matam Vijay-Kumar, Pamela Hankey-Giblin, K. Sandeep Prabhu, Robert F. Paulson, 2019, Science's STKE : signal transduction knowledge environment