Robert Paulson
Professor of Veterinary and Biomedical Sciences

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104 Henning Building
University Park, PA 16802 - rfp5@psu.edu
- 814-863-6306
Research Summary
The Paulson lab studies the mechanisms that regulate tissue regeneration with a focus on understanding the response to anemic and hypoxic stress
Huck Graduate Students
Huck Affiliations
- Integrative and Biomedical Physiology
- Molecular, Cellular, and Integrative Biosciences
- Center for Malaria Research
Links
Publication Tags
Erythropoiesis Macrophages Erythrocytes Heme Chemical Activation Prostaglandins Cyclopentenone Leukemia Inflammation Spleen Selenium 9 Deoxy Delta 9 Prostaglandin D2 Acute Myeloid Leukemia Time Anemia Ligand Therapeutics In Vitro Techniques Down Regulation Polymerization Effector Regeneration Amount Calcium Sphingosine KinaseMost Recent Publications
Interleukin-4 treatment reduces leukemia burden in acute myeloid leukemia
Fenghua Qian, Brooke E. Arner, Kathleen M. Kelly, Charyguly Annageldiyev, Arati Sharma, David F. Claxton, Robert F. Paulson, K. Sandeep Prabhu, 2022, FASEB Journal
A novel clinically relevant graft-versus-leukemia model in humanized mice
Bei Jia, Chenchen Zhao, Michael Bayerl, Hiroko Shike, David F. Claxton, W. Christopher Ehmann, Shin Mineishi, Todd D. Schell, Pan Zheng, Yi Zhang, Leonard D. Shultz, K. Sandeep Prabhu, Robert F. Paulson, Hong Zheng, 2021, Journal of Leukocyte Biology
Development of SKI-349, a dual-targeted inhibitor of sphingosine kinase and microtubule polymerization
Jeremy A. Hengst, Shailaja Hegde, Robert F. Paulson, Jong K. Yun, 2020, Bioorganic and Medicinal Chemistry Letters
Stress erythropoiesis: definitions and models for its study
Robert F. Paulson, Sneha Hariharan, Jane A. Little, 2020, Experimental Hematology on p. 43-54.e2
Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation
Yuanting Chen, Jie Xiang, Fenghua Qian, Bastihalli T. Diwakar, Baiye Ruan, Siyang Hao, K. Sandeep Prabhu, Robert F. Paulson, 2020, Blood on p. 235-246
Stress Erythropoiesis is a Key Inflammatory Response
Robert F. Paulson, Baiye Ruan, Siyang Hao, Yuanting Chen, 2020, Cells
Yap1 promotes proliferation of transiently amplifying stress erythroid progenitors during erythroid regeneration
Siyang Hao, Yurika Matsui, Zhi Chun Lai, Robert F. Paulson, 2019, Experimental Hematology on p. 42-54.e4
Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-αB activation in murine macrophages via changes in intracellular calcium
Bastihalli T. Diwakar, Ryan Yoast, Shaneice Nettleford, Fenghua Qian, Tai Jung Lee, Svanjita Berry, Ian Huffnagle, Randall M. Rossi, Mohamed Trebak, Robert F. Paulson, K. Sandeep Prabhu, 2019, FASEB Journal on p. 12838-12852
Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C
Laura F. Bennett, Chang Liao, Michael D. Quickel, Beng San Yeoh, Matam Vijay-Kumar, Pamela Hankey-Giblin, K. Sandeep Prabhu, Robert F. Paulson, 2019, Science's STKE : signal transduction knowledge environment
Downregulation of CD73 associates with T cell exhaustion in AML patients
Yaxian Kong, Bei Jia, Chenchen Zhao, David F. Claxton, Arati Sharma, Charyguly Annageldiyev, Joseph S. Fotos, Hui Zeng, Robert F. Paulson, K. Sandeep Prabhu, Hong Zheng, 2019, Journal of Hematology and Oncology
Most-Cited Papers
In vitro culture of stress erythroid progenitors identifies distinct progenitor populations and analogous human progenitors
Jie Xiang, Dai Chen Wu, Yuanting Chen, Robert F. Paulson, 2015, Blood on p. 1803-1812
Monocyte-derived macrophages expand the murine stress erythropoietic niche during the recovery from anemia
Chang Liao, K. Sandeep Prabhu, Robert F. Paulson, 2018, Blood on p. 2580-2593
Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C
Laura F. Bennett, Chang Liao, Michael D. Quickel, Beng San Yeoh, Matam Vijay-Kumar, Pamela Hankey-Giblin, K. Sandeep Prabhu, Robert F. Paulson, 2019, Science's STKE : signal transduction knowledge environment
Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis
Janet L.Manias Rothberg, Harinad B. Maganti, Hani Jrade, Christopher J. Porter, Gareth A. Palidwor, Christopher Cafariello, Hannah L. Battaion, Safwat T. Khan, Theodore J. Perkins, Robert F. Paulson, Caryn Y. Ito, William L. Stanford, 2018, Cell Discovery
Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis
Chang Liao, Ross C. Hardison, Mary J. Kennett, Bradley A. Carlson, Robert F. Paulson, K. Sandeep Prabhu, 2018, Blood on p. 2568-2580
Mechanisms of erythrocyte development and regeneration: Implications for regenerative medicine and beyond
Emery H. Bresnick, Kyle J. Hewitt, Charu Mehta, Sunduz Keles, Robert F. Paulson, Kirby D. Johnson, 2018, Journal of Embryology and Experimental Morphology
Stress Erythropoiesis is a Key Inflammatory Response
Robert F. Paulson, Baiye Ruan, Siyang Hao, Yuanting Chen, 2020, Cells
Targeting a new regulator of erythropoiesis to alleviate anemia
Robert F. Paulson, 2014, Nature Medicine on p. 334-335
Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche
Siyang Hao, Jie Xiang, Dai-Chen Wu, James Fraser, Baiye Ruan, Jingwei Cai, Andrew D. Patterson, Zhi Chun Lai, Robert F. Paulson, 2019, Blood advances on p. 2205-2217
Activation of PPARγ by endogenous prostaglandin J<sub>2</sub> mediates the antileukemic effect of selenium in murine leukemia
Emily R. Finch, Diwakar B. Tukaramrao, Laura L. Goodfield, Michael D. Quickel, Robert F. Paulson, K. Sandeep Prabhu, 2017, Blood on p. 1802-1810