Robert Paulson

Professor of Veterinary and Biomedical Sciences; Emphasis Area Representative, Genetics

Robert Paulson

Research Summary

The Paulson lab studies the mechanisms that regulate tissue regeneration with a focus on understanding the response to anemic and hypoxic stress

Graduate Students

Huck Institutes Affiliations


Most Recent Papers

Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis

Janet L.Manias Rothberg, Harinad B. Maganti, Hani Jrade, Christopher J. Porter, Gareth A. Palidwor, Christopher Cafariello, Hannah L. Battaion, Safwat T. Khan, Theodore J. Perkins, Robert F. Paulson, Caryn Y. Ito, William L. Stanford, 2018, Cell Discovery

Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis

Chang Liao, Ross C. Hardison, Mary J. Kennett, Bradley A. Carlson, Robert F. Paulson, K. Sandeep Prabhu, 2018, Blood on p. 2568-2580

Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease

Adwitia Dey, Joselyn N. Allen, James W. Fraser, Lindsay M. Snyder, Yuan Tian, Limin Zhang, Robert F. Paulson, Andrew Patterson, Margherita T. Cantorna, Pamela A. Hankey-Giblin, 2018, Frontiers in Immunology

The intricate role of selenium and selenoproteins in erythropoiesis

Chang Liao, Bradley A. Carlson, Robert F. Paulson, K. Sandeep Prabhu, 2018, Free Radical Biology and Medicine

GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia

Kyle J. Hewitt, Koichi R. Katsumura, Daniel R. Matson, Prithvia Devadas, Nobuyuki Tanimura, Alexander S. Hebert, Joshua J. Coon, Jin Soo Kim, Colin N. Dewey, Sunduz Keles, Siyang Hao, Robert F. Paulson, Emery H. Bresnick, 2017, Developmental Cell on p. 213-225.e4

Activation of PPARγ by endogenous prostaglandin J<sub>2</sub> mediates the antileukemic effect of selenium in murine leukemia

Emily R. Finch, Diwakar B. Tukaramrao, Laura L. Goodfield, Michael D. Quickel, Robert F. Paulson, K. Sandeep Prabhu, 2017, Blood on p. 1802-1810

SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models

Jeremy Hengst, Taryn E. Dick, Arati Sharma, Kenichiro Doi, Shailaja Hegde, Su Fern Tan, Laura Geffert, Todd E. Fox, Arun K. Sharma, Dhimant Desai, Shantu Amin, Mark Kester, Thomas P. Loughran, Robert Paulson, David Claxton, Hong-Gang Wang, Jong Yun, 2017, Cancer Translational Medicine on p. 109-121

Chemopreventive effects of dietary eicosapentaenoic acid supplementation in experimental myeloid leukemia

Emily R. Finch, Avinash K. Kudva, Michael D. Quickel, Laura L. Goodfield, Mary J. Kennett, Jay Whelan, Robert F. Paulson, K. Sandeep Prabhu, 2015, Cancer Prevention Research on p. 989-999

In vitro culture of stress erythroid progenitors identifies distinct progenitor populations and analogous human progenitors

Jie Xiang, Dai Chen Wu, Yuanting Chen, Robert F. Paulson, 2015, Blood on p. 1803-1812

Selenium suppresses leukemia through the action of endogenous eicosanoids

Ujjawal H. Gandhi, Naveen Kaushal, Shailaja Hegde, Emily R. Finch, Avinash K. Kudva, Mary J. Kennett, Craig T. Jordan, Robert F. Paulson, K. Sandeep Prabhu, 2014, Cancer Research on p. 3890-3901

High-Impact Papers

Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

Toshihiko Tanno, Prashanth Porayette, Orapan Sripichai, Seung Jae Noh, Colleen Byrnes, Ajoy Bhupatiraju, Y. Terry Lee, Julia B. Goodnough, Omid Harandi, Tomas Ganz, Robert F. Paulson, Jeffery L. Miller, 2009, Blood on p. 181-186

Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration

Eirini Trompouki, Teresa V. Bowman, Lee N. Lawton, Zi Peng Fan, Dai Chen Wu, Anthony Dibiase, Corey S. Martin, Jennifer N. Cech, Anna K. Sessa, Jocelyn L. Leblanc, Pulin Li, Ellen M. Durand, Christian Mosimann, Garrett C. Heffner, George Q. Daley, Robert F. Paulson, Richard A. Young, Leonard I. Zon, 2011, Cell on p. 577-589

Stress erythropoiesis

Robert F. Paulson, Lei Shi, Dai Chen Wu, 2011, Current Opinion in Hematology on p. 139-145

Maintenance of the BMP4-dependent stress erythropoiesis pathway in the murine spleen requires hedgehog signaling

John M. Perry, Omid F. Harandi, Prashanth Porayette, Shailaja Hegde, Arun K. Kannan, Robert F. Paulson, 2009, Blood on p. 911-918

Selenoprotein-dependent up-regulation of hematopoietic prostaglandin D <sub>2</sub> synthase in macrophages is mediated through the activation of Peroxisome Proliferator-activated Receptor (PPAR) γ

Ujjawal H. Gandhi, Naveen Kaushal, Kodihalli C. Ravindra, Shailaja Hegde, Shakira M. Nelson, Vivek Narayan, Hema Vunta, Robert F. Paulson, K. Sandeep Prabhu, 2011, Journal of Biological Chemistry on p. 27471-27482

Murine erythroid short-term radioprotection requires a BMP4-dependent, self-renewing population of stress erythroid progenitors

Omid F. Harandi, Shailaja Hedge, Dai Chen Wu, Daniel Mckeone, Robert F. Paulson, 2010, Journal of Clinical Investigation on p. 4507-4519

Δ <sup>12</sup>-prostaglandin J <sub>3</sub>, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice

Shailaja Hegde, Naveen Kaushal, Kodihalli C. Ravindra, Christopher Chiaro, Kelsey T. Hafer, Ujjawal H. Gandhi, Jerry T. Thompson, John P. Van Den Heuvel, Mary J. Kennett, Pamela Hankey, Robert F. Paulson, K. Sandeep Prabhu, 2011, Blood on p. 6909-6919

Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiation

S. Hegde, S. Ni, S. He, D. Yoon, G. S. Feng, S. S. Watowich, R. F. Paulson, P. A. Hankey, 2009, Oncogene on p. 3349-3359

Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia

Dai Chen Wu, Robert F. Paulson, 2010, PLoS One

Extramedullary erythropoiesis in the adult liver requires BMP-4/Smad5-dependent signaling

Laurie E. Lenox, Lei Shi, Shailaja Hegde, Robert F. Paulson, 2009, Experimental Hematology on p. 549-558