Robert Paulson

Professor of Veterinary and Biomedical Sciences; Emphasis Area Representative, Genetics

Robert Paulson

Research Summary

The Paulson lab studies the mechanisms that regulate tissue regeneration with a focus on understanding the response to anemic and hypoxic stress

Graduate Students

Huck Affiliations


Publication Tags

Erythropoiesis Selenium Anemia Spleen Prostaglandins Selenoproteins Stem Cells Genes Macrophages Chemical Activation Erythrocytes Prostaglandins D Leukemia Proteins Hypoxia Cyclopentenone Population Regeneration Hepcidins Ppar Gamma Omega 3 Fatty Acids Erythroblasts Erythroid Cells Up Regulation Transcription Factors

Most Recent Papers

Downregulation of CD73 associates with T cell exhaustion in AML patients

Yaxian Kong, Bei Jia, Chenchen Zhao, David Claxton, Arati Sharma, Charyguly Annageldiyev, Joseph Fotos, Hui Zeng, Robert Paulson, Kumble Sandeep Prabhu, Hong Zheng, 2019, Journal of Hematology and Oncology

Dual role of a C-terminally truncated isoform of large tumor suppressor kinase 1 in the regulation of hippo signaling and tissue growth

Yurika Matsui, Yifan Zhang, Robert Paulson, Zhi-chun Lai, 2019, DNA and Cell Biology on p. 91-106

Monocyte-derived macrophages expand the murine stress erythropoietic niche during the recovery from anemia

Chang Liao, Kumble Sandeep Prabhu, Robert Paulson, 2018, Blood on p. 2580-2593

Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis

Janet L.Manias Rothberg, Harinad B. Maganti, Hani Jrade, Christopher J. Porter, Gareth A. Palidwor, Christopher Cafariello, Hannah L. Battaion, Safwat T. Khan, Theodore J. Perkins, Robert Paulson, Caryn Y. Ito, William L. Stanford, 2018, Cell Discovery

Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis

Chang Liao, Ross Cameron Hardison, Mary J. Kennett, Bradley A. Carlson, Robert Paulson, Kumble Sandeep Prabhu, 2018, Blood on p. 2568-2580

Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease

Adwitia Dey, Joselyn N. Allen, James W. Fraser, Lindsay M. Snyder, Yuan Tian, Limin Zhang, Robert Paulson, Andrew David Patterson, Margherita Teresa-Anna Cantorna, Pamela Hankey Giblin, 2018, Frontiers in immunology

The intricate role of selenium and selenoproteins in erythropoiesis

Chang Liao, Bradley A. Carlson, Robert F. Paulson, K. Sandeep Prabhu, 2018, Free Radical Biology and Medicine

GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia

Kyle J. Hewitt, Koichi R. Katsumura, Daniel R. Matson, Prithvia Devadas, Nobuyuki Tanimura, Alexander S. Hebert, Joshua J. Coon, Jin Soo Kim, Colin N. Dewey, Sunduz Keles, Siyang Hao, Robert Paulson, Emery H. Bresnick, 2017, Developmental Cell on p. 213-225.e4

Activation of PPARγ by endogenous prostaglandin J<sub>2</sub> mediates the antileukemic effect of selenium in murine leukemia

Emily R. Finch, Diwakar B. Tukaramrao, Laura L. Goodfield, Michael D. Quickel, Robert Paulson, Kumble Sandeep Prabhu, 2017, Blood on p. 1802-1810

SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models

Jeremy Hengst, Taryn E. Dick, Arati Sharma, Kenichiro Doi, Shailaja Hegde, Su Fern Tan, Laura Geffert, Todd E. Fox, Arun K. Sharma, Dhimant Desai, Shantu Amin, Mark Kester, Thomas P. Loughran, Robert Paulson, David Claxton, Hong-Gang Wang, Jong Yun, 2017, Cancer Translational Medicine on p. 109-121

High-Impact Papers

Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

Toshihiko Tanno, Prashanth Porayette, Orapan Sripichai, Seung Jae Noh, Colleen Byrnes, Ajoy Bhupatiraju, Y. Terry Lee, Julia B. Goodnough, Omid Harandi, Tomas Ganz, Robert Paulson, Jeffery L. Miller, 2009, Blood on p. 181-186

Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration

Eirini Trompouki, Teresa V. Bowman, Lee N. Lawton, Zi Peng Fan, Dai Chen Wu, Anthony Dibiase, Corey S. Martin, Jennifer N. Cech, Anna K. Sessa, Jocelyn L. Leblanc, Pulin Li, Ellen M. Durand, Christian Mosimann, Garrett C. Heffner, George Q. Daley, Robert Paulson, Richard A. Young, Leonard I. Zon, 2011, Cell on p. 577-589

Stress erythropoiesis

Robert Paulson, Lei Shi, Dai Chen Wu, 2011, Current Opinion in Hematology on p. 139-145

Selenoprotein-dependent up-regulation of hematopoietic prostaglandin D <sub>2</sub> synthase in macrophages is mediated through the activation of Peroxisome Proliferator-activated Receptor (PPAR) γ

Ujjawal H. Gandhi, Naveen Kaushal, Kodihalli C. Ravindra, Shailaja Hegde, Shakira M. Nelson, Vivek Narayan, Hema Vunta, Robert Paulson, Kumble Sandeep Prabhu, 2011, Journal of Biological Chemistry on p. 27471-27482

Maintenance of the BMP4-dependent stress erythropoiesis pathway in the murine spleen requires hedgehog signaling

John M. Perry, Omid F. Harandi, Prashanth Porayette, Shailaja Hegde, Arun K. Kannan, Robert F. Paulson, 2009, Blood on p. 911-918

Murine erythroid short-term radioprotection requires a BMP4-dependent, self-renewing population of stress erythroid progenitors

Omid F. Harandi, Shailaja Hedge, Dai Chen Wu, Daniel Mckeone, Robert Paulson, 2010, Journal of Clinical Investigation on p. 4507-4519

Δ <sup>12</sup>-prostaglandin J <sub>3</sub>, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice

Shailaja Hegde, Naveen Kaushal, Kodihalli C. Ravindra, Christopher Chiaro, Kelsey T. Hafer, Ujjawal H. Gandhi, Jerry T. Thompson, John Patrick Vanden Heuvel, Mary J. Kennett, Pamela Hankey Giblin, Robert Paulson, Kumble Sandeep Prabhu, 2011, Blood on p. 6909-6919

Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiation

S. Hegde, S. Ni, S. He, D. Yoon, G. S. Feng, S. S. Watowich, Robert Paulson, Pamela Hankey Giblin, 2009, Oncogene on p. 3349-3359

Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia

Dai Chen Wu, Robert Paulson, 2010, PLoS One

The regulation of erythropoiesis by selenium in mice

Naveen Kaushal, Shailaja Hegde, Jeanne Ann Lumadue, Robert Paulson, Kumble Sandeep Prabhu, 2011, Antioxidants and Redox Signaling on p. 1403-1412