Robert Paulson

Professor of Veterinary and Biomedical Sciences

Robert Paulson

Research Summary

The Paulson lab studies the mechanisms that regulate tissue regeneration with a focus on understanding the response to anemic and hypoxic stress

Graduate Students

Huck Affiliations

Links

Publication Tags

Macrophages Erythropoiesis Selenium Prostaglandins Anemia Cyclopentenone Chemical Activation Erythrocytes Leukemia Proteins Stem Cells Selenoproteins Heme Inflammation Spleen Recovery Prostaglandins D 9 Deoxy Delta 9 Prostaglandin D2 Down Regulation Mutation Calcium Regeneration Polycomb Repressive Complex 2 Ppar Gamma Lipopolysaccharides

Most Recent Papers

Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-κB activation in murine macrophages via changes in intracellular calcium

Bastihalli T. Diwakar, Ryan Yoast, Shaneice Nettleford, Fenghua Qian, Tai Jung Lee, Svanjita Berry, Ian Huffnagle, Randall M. Rossi, Mohamed Trebak, Robert F. Paulson, K. Sandeep Prabhu, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology on p. 12838-12852

Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C

Laura F. Bennett, Chang Liao, Michael D. Quickel, Beng San Yeoh, Matam Vijay-Kumar, Pamela Hankey-Giblin, K. Sandeep Prabhu, Robert F. Paulson, 2019, Science signaling

Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche

Siyang Hao, Jie Xiang, Dai Chen Wu, James W. Fraser, Baiye Ruan, Jingwei Cai, Andrew D. Patterson, Zhi Chun Lai, Robert F. Paulson, 2019, Blood Advances on p. 2205-2217

Downregulation of CD73 associates with T cell exhaustion in AML patients

Yaxian Kong, Bei Jia, Chenchen Zhao, David Claxton, Arati Sharma, Charyguly Annageldiyev, Joseph Fotos, Hui Zeng, Robert Paulson, Kumble Sandeep Prabhu, Hong Zheng, 2019, Journal of Hematology and Oncology

Yap1 promotes proliferation of transiently amplifying stress erythroid progenitors during erythroid regeneration

Siyang Hao, Yurika Matsui, Zhi Chun Lai, Robert F. Paulson, 2019, Experimental Hematology

Dual role of a C-terminally truncated isoform of large tumor suppressor kinase 1 in the regulation of hippo signaling and tissue growth

Yurika Matsui, Yifan Zhang, Robert F. Paulson, Zhi Chun Lai, 2019, DNA and Cell Biology on p. 91-106

Monocyte-derived macrophages expand the murine stress erythropoietic niche during the recovery from anemia

Chang Liao, K. Sandeep Prabhu, Robert F. Paulson, 2018, Blood on p. 2580-2593

Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis

Janet L.Manias Rothberg, Harinad B. Maganti, Hani Jrade, Christopher J. Porter, Gareth A. Palidwor, Christopher Cafariello, Hannah L. Battaion, Safwat T. Khan, Theodore J. Perkins, Robert F. Paulson, Caryn Y. Ito, William L. Stanford, 2018, Cell Discovery

Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease

Adwitia Dey, Joselyn N. Allen, James W. Fraser, Lindsay M. Snyder, Yuan Tian, Limin Zhang, Robert F. Paulson, Andrew Patterson, Margherita T. Cantorna, Pamela A. Hankey-Giblin, 2018, Frontiers in immunology

The intricate role of selenium and selenoproteins in erythropoiesis

Chang Liao, Bradley A. Carlson, Robert F. Paulson, K. Sandeep Prabhu, 2018, Free Radical Biology and Medicine

Most-Cited Papers

Selenoprotein-dependent up-regulation of hematopoietic prostaglandin D <sub>2</sub> synthase in macrophages is mediated through the activation of Peroxisome Proliferator-activated Receptor (PPAR) γ

Ujjawal H. Gandhi, Naveen Kaushal, Kodihalli C. Ravindra, Shailaja Hegde, Shakira M. Nelson, Vivek Narayan, Hema Vunta, Robert F. Paulson, K. Sandeep Prabhu, 2011, Journal of Biological Chemistry on p. 27471-27482

Murine erythroid short-term radioprotection requires a BMP4-dependent, self-renewing population of stress erythroid progenitors

Omid F. Harandi, Shailaja Hedge, Dai Chen Wu, Daniel Mckeone, Robert F. Paulson, 2010, Journal of Clinical Investigation on p. 4507-4519

Δ <sup>12</sup>-prostaglandin J <sub>3</sub>, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice

Shailaja Hegde, Naveen Kaushal, Kodihalli C. Ravindra, Christopher Chiaro, Kelsey T. Hafer, Ujjawal H. Gandhi, Jerry T. Thompson, John Patrick Vanden Heuvel, Mary J. Kennett, Pamela Hankey Giblin, Robert Paulson, Kumble Sandeep Prabhu, 2011, Blood on p. 6909-6919

The regulation of erythropoiesis by selenium in mice

Naveen Kaushal, Shailaja Hegde, Jeanne Ann Lumadue, Robert Paulson, Kumble Sandeep Prabhu, 2011, Antioxidants and Redox Signaling on p. 1403-1412

A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis

Michael R. Hughes, Nicole Anderson, Steven Maltby, Justin Wong, Zorana Berberovic, Connie S. Birkenmeier, D. James Haddon, Kamal Garcha, Ann Flenniken, Lucy R. Osborne, S. Lee Adamson, Janet Rossant, Luanne L. Peters, Mark D. Minden, Robert Paulson, Chen Wang, Dwayne L. Barber, Kelly M. McNagny, William L. Stanford, 2011, Experimental Hematology

Self-renewal of leukemia stem cells in friend virus-induced erythroleukemia requires proviral insertional activation of spi1 and hedgehog signaling but not mutation of p53

Shailaja Hegde, Pamela Hankey Giblin, Robert Paulson, 2012, STEM CELLS on p. 121-130

GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia

Kyle J. Hewitt, Koichi R. Katsumura, Daniel R. Matson, Prithvia Devadas, Nobuyuki Tanimura, Alexander S. Hebert, Joshua J. Coon, Jin Soo Kim, Colin N. Dewey, Sunduz Keles, Siyang Hao, Robert F. Paulson, Emery H. Bresnick, 2017, Developmental Cell on p. 213-225.e4

Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis

Janet L.Manias Rothberg, Harinad B. Maganti, Hani Jrade, Christopher J. Porter, Gareth A. Palidwor, Christopher Cafariello, Hannah L. Battaion, Safwat T. Khan, Theodore J. Perkins, Robert F. Paulson, Caryn Y. Ito, William L. Stanford, 2018, Cell Discovery

Activation of PPARγ by endogenous prostaglandin J<sub>2</sub> mediates the antileukemic effect of selenium in murine leukemia

Emily R. Finch, Diwakar B. Tukaramrao, Laura L. Goodfield, Michael D. Quickel, Robert F. Paulson, K. Sandeep Prabhu, 2017, Blood on p. 1802-1810

Monocyte-derived macrophages expand the murine stress erythropoietic niche during the recovery from anemia

Chang Liao, K. Sandeep Prabhu, Robert F. Paulson, 2018, Blood on p. 2580-2593