Robert Paulson

Professor of Veterinary and Biomedical Sciences

Robert Paulson

Research Summary

The Paulson lab studies the mechanisms that regulate tissue regeneration with a focus on understanding the response to anemic and hypoxic stress

Graduate Students

Huck Affiliations


Publication Tags

Erythropoiesis Macrophages Selenium Anemia Spleen Genes Chemical Activation Prostaglandins Leukemia Stem Cells Selenoproteins Population Cyclopentenone Hypoxia Inflammation Recovery Erythrocytes Proteins In Vitro Techniques Neoplasms Calcium Ppar Gamma Heme Regeneration Down Regulation

Most Recent Papers

Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-κB activation in murine macrophages via changes in intracellular calcium

Bastihalli T. Diwakar, Ryan Yoast, Shaneice Nettleford, Fenghua Qian, Tai Jung Lee, Svanjita Berry, Ian Huffnagle, Randall M. Rossi, Mohamed Trebak, Robert F. Paulson, K. Sandeep Prabhu, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology on p. 12838-12852

Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C

Laura F. Bennett, Chang Liao, Michael D. Quickel, Beng San Yeoh, Matam Vijay-Kumar, Pamela Hankey-Giblin, K. Sandeep Prabhu, Robert F. Paulson, 2019, Science signaling

Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche

Siyang Hao, Jie Xiang, Dai Chen Wu, James W. Fraser, Baiye Ruan, Jingwei Cai, Andrew D. Patterson, Zhi Chun Lai, Robert F. Paulson, 2019, Blood Advances on p. 2205-2217

Downregulation of CD73 associates with T cell exhaustion in AML patients

Yaxian Kong, Bei Jia, Chenchen Zhao, David Claxton, Arati Sharma, Charyguly Annageldiyev, Joseph Fotos, Hui Zeng, Robert Paulson, Kumble Sandeep Prabhu, Hong Zheng, 2019, Journal of Hematology and Oncology

Dual role of a C-terminally truncated isoform of large tumor suppressor kinase 1 in the regulation of hippo signaling and tissue growth

Yurika Matsui, Yifan Zhang, Robert F. Paulson, Zhi Chun Lai, 2019, DNA and Cell Biology on p. 91-106

Yap1 promotes proliferation of transiently amplifying stress erythroid progenitors during erythroid regeneration

Siyang Hao, Yurika Matsui, Zhi Chun Lai, Robert F. Paulson, 2019, Experimental Hematology

Monocyte-derived macrophages expand the murine stress erythropoietic niche during the recovery from anemia

Chang Liao, K. Sandeep Prabhu, Robert F. Paulson, 2018, Blood on p. 2580-2593

Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis

Janet L.Manias Rothberg, Harinad B. Maganti, Hani Jrade, Christopher J. Porter, Gareth A. Palidwor, Christopher Cafariello, Hannah L. Battaion, Safwat T. Khan, Theodore J. Perkins, Robert F. Paulson, Caryn Y. Ito, William L. Stanford, 2018, Cell Discovery

Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis

Chang Liao, Ross Cameron Hardison, Mary J. Kennett, Bradley A. Carlson, Robert Paulson, Kumble Sandeep Prabhu, 2018, Blood on p. 2568-2580

Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease

Adwitia Dey, Joselyn N. Allen, James W. Fraser, Lindsay M. Snyder, Yuan Tian, Limin Zhang, Robert F. Paulson, Andrew Patterson, Margherita T. Cantorna, Pamela A. Hankey-Giblin, 2018, Frontiers in immunology

Most-Cited Papers

Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration

Eirini Trompouki, Teresa V. Bowman, Lee N. Lawton, Zi Peng Fan, Dai Chen Wu, Anthony Dibiase, Corey S. Martin, Jennifer N. Cech, Anna K. Sessa, Jocelyn L. Leblanc, Pulin Li, Ellen M. Durand, Christian Mosimann, Garrett C. Heffner, George Q. Daley, Robert F. Paulson, Richard A. Young, Leonard I. Zon, 2011, Cell on p. 577-589

Stress erythropoiesis

Robert Paulson, Lei Shi, Dai Chen Wu, 2011, Current Opinion in Hematology on p. 139-145

Selenoprotein-dependent up-regulation of hematopoietic prostaglandin D <sub>2</sub> synthase in macrophages is mediated through the activation of Peroxisome Proliferator-activated Receptor (PPAR) γ

Ujjawal H. Gandhi, Naveen Kaushal, Kodihalli C. Ravindra, Shailaja Hegde, Shakira M. Nelson, Vivek Narayan, Hema Vunta, Robert F. Paulson, K. Sandeep Prabhu, 2011, Journal of Biological Chemistry on p. 27471-27482

Murine erythroid short-term radioprotection requires a BMP4-dependent, self-renewing population of stress erythroid progenitors

Omid F. Harandi, Shailaja Hedge, Dai Chen Wu, Daniel Mckeone, Robert F. Paulson, 2010, Journal of Clinical Investigation on p. 4507-4519

Δ <sup>12</sup>-prostaglandin J <sub>3</sub>, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice

Shailaja Hegde, Naveen Kaushal, Kodihalli C. Ravindra, Christopher Chiaro, Kelsey T. Hafer, Ujjawal H. Gandhi, Jerry T. Thompson, John Patrick Vanden Heuvel, Mary J. Kennett, Pamela Hankey Giblin, Robert Paulson, Kumble Sandeep Prabhu, 2011, Blood on p. 6909-6919

Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia

Dai Chen Wu, Robert Paulson, 2010, PLoS One

In vitro culture of stress erythroid progenitors identifies distinct progenitor populations and analogous human progenitors

Jie Xiang, Dai Chen Wu, Yuanting Chen, Robert F. Paulson, 2015, Blood on p. 1803-1812

The regulation of erythropoiesis by selenium in mice

Naveen Kaushal, Shailaja Hegde, Jeanne Ann Lumadue, Robert Paulson, Kumble Sandeep Prabhu, 2011, Antioxidants and Redox Signaling on p. 1403-1412

Self-renewal of leukemia stem cells in friend virus-induced erythroleukemia requires proviral insertional activation of spi1 and hedgehog signaling but not mutation of p53

Shailaja Hegde, Pamela Hankey Giblin, Robert Paulson, 2012, STEM CELLS on p. 121-130

Selenium suppresses leukemia through the action of endogenous eicosanoids

Ujjawal H. Gandhi, Naveen Kaushal, Shailaja Hegde, Emily R. Finch, Avinash K. Kudva, Mary J. Kennett, Craig T. Jordan, Robert F. Paulson, K. Sandeep Prabhu, 2014, Cancer Research on p. 3890-3901