Robert Paulson

Professor of Veterinary and Biomedical Sciences

Robert Paulson

Research Summary

The Paulson lab studies the mechanisms that regulate tissue regeneration with a focus on understanding the response to anemic and hypoxic stress

Huck Graduate Students

Huck Affiliations


Publication Tags

Erythropoiesis Macrophages Selenium Prostaglandins Chemical Activation Stem Cells Cyclopentenone Leukemia Genes Selenoproteins Anemia 9 Deoxy Delta 9 Prostaglandin D2 Erythrocytes Spleen Proteins Prostaglandins D In Vitro Techniques Neoplasms Down Regulation Sphingosine Kinase Omega 3 Fatty Acids Erythropoietin Receptors Heme Calcium Polymerization

Most Recent Papers

Development of SKI-349, a dual-targeted inhibitor of sphingosine kinase and microtubule polymerization

Jeremy A. Hengst, Shailaja Hegde, Robert F. Paulson, Jong K. Yun, 2020, Bioorganic and Medicinal Chemistry Letters

Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation

Yuanting Chen, Jie Xiang, Fenghua Qian, Bastihalli T. Diwakar, Baiye Ruan, Siyang Hao, K. Sandeep Prabhu, Robert F. Paulson, 2020, Blood on p. 235-246

Yap1 promotes proliferation of transiently amplifying stress erythroid progenitors during erythroid regeneration

Siyang Hao, Yurika Matsui, Zhi Chun Lai, Robert F. Paulson, 2019, Experimental Hematology on p. 42-54.e4

Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-αB activation in murine macrophages via changes in intracellular calcium

Bastihalli T. Diwakar, Ryan Yoast, Shaneice Nettleford, Fenghua Qian, Tai Jung Lee, Svanjita Berry, Ian Huffnagle, Randall M. Rossi, Mohamed Trebak, Robert F. Paulson, K. Sandeep Prabhu, 2019, FASEB Journal on p. 12838-12852

Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C

Laura F. Bennett, Chang Liao, Michael D. Quickel, Beng San Yeoh, Matam Vijay-Kumar, Pamela Hankey-Giblin, K. Sandeep Prabhu, Robert F. Paulson, 2019, Science Signaling

Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche

Siyang Hao, Jie Xiang, Dai Chen Wu, James W. Fraser, Baiye Ruan, Jingwei Cai, Andrew D. Patterson, Zhi Chun Lai, Robert F. Paulson, 2019, Blood advances on p. 2205-2217

Downregulation of CD73 associates with T cell exhaustion in AML patients

Yaxian Kong, Bei Jia, Chenchen Zhao, David Claxton, Arati Sharma, Charyguly Annageldiyev, Joseph Fotos, Hui Zeng, Robert Paulson, Kumble Sandeep Prabhu, Hong Zheng, 2019, Journal of Hematology and Oncology

Dual role of a C-terminally truncated isoform of large tumor suppressor kinase 1 in the regulation of hippo signaling and tissue growth

Yurika Matsui, Yifan Zhang, Robert F. Paulson, Zhi Chun Lai, 2019, DNA and Cell Biology on p. 91-106

Monocyte-derived macrophages expand the murine stress erythropoietic niche during the recovery from anemia

Chang Liao, K. Sandeep Prabhu, Robert F. Paulson, 2018, Blood on p. 2580-2593

Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis

Janet L.Manias Rothberg, Harinad B. Maganti, Hani Jrade, Christopher J. Porter, Gareth A. Palidwor, Christopher Cafariello, Hannah L. Battaion, Safwat T. Khan, Theodore J. Perkins, Robert F. Paulson, Caryn Y. Ito, William L. Stanford, 2018, Cell Discovery

Most-Cited Papers

Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration

Eirini Trompouki, Teresa V. Bowman, Lee N. Lawton, Zi Peng Fan, Dai Chen Wu, Anthony Dibiase, Corey S. Martin, Jennifer N. Cech, Anna K. Sessa, Jocelyn L. Leblanc, Pulin Li, Ellen M. Durand, Christian Mosimann, Garrett C. Heffner, George Q. Daley, Robert F. Paulson, Richard A. Young, Leonard I. Zon, 2011, Cell on p. 577-589

Stress erythropoiesis

Robert Paulson, Lei Shi, Dai Chen Wu, 2011, Current Opinion in Hematology on p. 139-145

Selenoprotein-dependent up-regulation of hematopoietic prostaglandin D <sub>2</sub> synthase in macrophages is mediated through the activation of Peroxisome Proliferator-activated Receptor (PPAR) γ

Ujjawal H. Gandhi, Naveen Kaushal, Kodihalli C. Ravindra, Shailaja Hegde, Shakira M. Nelson, Vivek Narayan, Hema Vunta, Robert F. Paulson, K. Sandeep Prabhu, 2011, Journal of Biological Chemistry on p. 27471-27482

Δ <sup>12</sup>-prostaglandin J <sub>3</sub>, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice

Shailaja Hegde, Naveen Kaushal, Kodihalli C. Ravindra, Christopher Chiaro, Kelsey T. Hafer, Ujjawal H. Gandhi, Jerry T. Thompson, John Patrick Vanden Heuvel, Mary J. Kennett, Pamela Hankey Giblin, Robert Paulson, Kumble Sandeep Prabhu, 2011, Blood on p. 6909-6919

In vitro culture of stress erythroid progenitors identifies distinct progenitor populations and analogous human progenitors

Jie Xiang, Dai Chen Wu, Yuanting Chen, Robert F. Paulson, 2015, Blood on p. 1803-1812

The regulation of erythropoiesis by selenium in mice

Naveen Kaushal, Shailaja Hegde, Jeanne Lumadue, Robert F. Paulson, K. Sandeep Prabhu, 2011, Antioxidants and Redox Signaling on p. 1403-1412

A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis.

M Hughes, Nancy Anderson, S Maltby, J Wong, Z Berberovic, C Birkenmeier, D Haddon, K Garcha, A Flenniken, L Osborne, S Adamson, J Rossant, L Peters, M Minden, Robert Paulson, Chao-Yang Wang, D Barber, K McNagny, W Stanford, 2011, Experimental Hematology on p. 601-611

Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis

Chang Liao, Ross Cameron Hardison, Mary J. Kennett, Bradley A. Carlson, Robert Paulson, Kumble Sandeep Prabhu, 2018, Blood on p. 2568-2580

Selenium suppresses leukemia through the action of endogenous eicosanoids

Ujjawal H. Gandhi, Naveen Kaushal, Shailaja Hegde, Emily R. Finch, Avinash K. Kudva, Mary J. Kennett, Craig T. Jordan, Robert F. Paulson, K. Sandeep Prabhu, 2014, Cancer Research on p. 3890-3901

Activation of PPARγ by endogenous prostaglandin J<sub>2</sub> mediates the antileukemic effect of selenium in murine leukemia

Emily R. Finch, Diwakar B. Tukaramrao, Laura L. Goodfield, Michael D. Quickel, Robert F. Paulson, K. Sandeep Prabhu, 2017, Blood on p. 1802-1810