Robert Paulson

Professor of Veterinary and Biomedical Sciences

Robert Paulson

Research Summary

The Paulson lab studies the mechanisms that regulate tissue regeneration with a focus on understanding the response to anemic and hypoxic stress

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Erythropoiesis Macrophages Erythrocytes Leukemia Heme Selenium Chemical Activation Prostaglandins Cyclopentenone Inflammation Spleen 9 Deoxy Delta 9 Prostaglandin D2 Acute Myeloid Leukemia Time Anemia Ligand Therapeutics In Vitro Techniques Down Regulation Polymerization Effector Regeneration Amount Calcium Sphingosine Kinase

Most Recent Publications

Interleukin-4 treatment reduces leukemia burden in acute myeloid leukemia

Fenghua Qian, Brooke E. Arner, Kathleen M. Kelly, Charyguly Annageldiyev, Arati Sharma, David F. Claxton, Robert F. Paulson, K. Sandeep Prabhu, 2022, FASEB Journal

A novel clinically relevant graft-versus-leukemia model in humanized mice

Bei Jia, Chenchen Zhao, Michael Bayerl, Hiroko Shike, David F. Claxton, W. Christopher Ehmann, Shin Mineishi, Todd D. Schell, Pan Zheng, Yi Zhang, Leonard D. Shultz, K. Sandeep Prabhu, Robert F. Paulson, Hong Zheng, 2021, Journal of Leukocyte Biology

Development of SKI-349, a dual-targeted inhibitor of sphingosine kinase and microtubule polymerization

Jeremy A. Hengst, Shailaja Hegde, Robert F. Paulson, Jong K. Yun, 2020, Bioorganic and Medicinal Chemistry Letters

Stress erythropoiesis: definitions and models for its study

Robert F. Paulson, Sneha Hariharan, Jane A. Little, 2020, Experimental Hematology on p. 43-54.e2

Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation

Yuanting Chen, Jie Xiang, Fenghua Qian, Bastihalli T. Diwakar, Baiye Ruan, Siyang Hao, K. Sandeep Prabhu, Robert F. Paulson, 2020, Blood on p. 235-246

Stress Erythropoiesis is a Key Inflammatory Response

Robert F. Paulson, Baiye Ruan, Siyang Hao, Yuanting Chen, 2020, Cells

Yap1 promotes proliferation of transiently amplifying stress erythroid progenitors during erythroid regeneration

Siyang Hao, Yurika Matsui, Zhi Chun Lai, Robert F. Paulson, 2019, Experimental Hematology on p. 42-54.e4

Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-αB activation in murine macrophages via changes in intracellular calcium

Bastihalli T. Diwakar, Ryan Yoast, Shaneice Nettleford, Fenghua Qian, Tai Jung Lee, Svanjita Berry, Ian Huffnagle, Randall M. Rossi, Mohamed Trebak, Robert F. Paulson, K. Sandeep Prabhu, 2019, FASEB Journal on p. 12838-12852

Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C

Laura F. Bennett, Chang Liao, Michael D. Quickel, Beng San Yeoh, Matam Vijay-Kumar, Pamela Hankey-Giblin, K. Sandeep Prabhu, Robert F. Paulson, 2019, Science's STKE : signal transduction knowledge environment

Downregulation of CD73 associates with T cell exhaustion in AML patients

Yaxian Kong, Bei Jia, Chenchen Zhao, David F. Claxton, Arati Sharma, Charyguly Annageldiyev, Joseph S. Fotos, Hui Zeng, Robert F. Paulson, K. Sandeep Prabhu, Hong Zheng, 2019, Journal of Hematology and Oncology

Most-Cited Papers

In vitro culture of stress erythroid progenitors identifies distinct progenitor populations and analogous human progenitors

Jie Xiang, Dai Chen Wu, Yuanting Chen, Robert F. Paulson, 2015, Blood on p. 1803-1812

Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C

Laura F. Bennett, Chang Liao, Michael D. Quickel, Beng San Yeoh, Matam Vijay-Kumar, Pamela Hankey-Giblin, K. Sandeep Prabhu, Robert F. Paulson, 2019, Science's STKE : signal transduction knowledge environment

Monocyte-derived macrophages expand the murine stress erythropoietic niche during the recovery from anemia

Chang Liao, K. Sandeep Prabhu, Robert F. Paulson, 2018, Blood on p. 2580-2593

Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis

Chang Liao, Ross C. Hardison, Mary J. Kennett, Bradley A. Carlson, Robert F. Paulson, K. Sandeep Prabhu, 2018, Blood on p. 2568-2580

Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis

Janet L.Manias Rothberg, Harinad B. Maganti, Hani Jrade, Christopher J. Porter, Gareth A. Palidwor, Christopher Cafariello, Hannah L. Battaion, Safwat T. Khan, Theodore J. Perkins, Robert F. Paulson, Caryn Y. Ito, William L. Stanford, 2018, Cell Discovery

Mechanisms of erythrocyte development and regeneration: Implications for regenerative medicine and beyond

Emery H. Bresnick, Kyle J. Hewitt, Charu Mehta, Sunduz Keles, Robert F. Paulson, Kirby D. Johnson, 2018, Journal of Embryology and Experimental Morphology

Targeting a new regulator of erythropoiesis to alleviate anemia

Robert F. Paulson, 2014, Nature Medicine on p. 334-335

Stress Erythropoiesis is a Key Inflammatory Response

Robert F. Paulson, Baiye Ruan, Siyang Hao, Yuanting Chen, 2020, Cells

Activation of PPARγ by endogenous prostaglandin J<sub>2</sub> mediates the antileukemic effect of selenium in murine leukemia

Emily R. Finch, Diwakar B. Tukaramrao, Laura L. Goodfield, Michael D. Quickel, Robert F. Paulson, K. Sandeep Prabhu, 2017, Blood on p. 1802-1810

Selenium suppresses leukemia through the action of endogenous eicosanoids

Ujjawal H. Gandhi, Naveen Kaushal, Shailaja Hegde, Emily R. Finch, Avinash K. Kudva, Mary J. Kennett, Craig T. Jordan, Robert F. Paulson, K. Sandeep Prabhu, 2014, Cancer Research on p. 3890-3901