Parisa Kalantari

Assistant Professor of Immunology

112 Research Unit A
University Park, PA
puk103@psu.edu
814-865-7696

Research Summary

Host-parasite interactions using Schistosoma mansoni-induced liver inflammation in mouse models. Modulation of immune responses by the parasite as well as the role of inflammasomes in inducing schistosomiasis.

Huck Graduate Students

Megan Nitchman

Huck Affiliations

Molecular, Cellular, and Integrative Biosciences

Center for Cellular Dynamics

Center for Malaria Research

Publication Tags

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Inflammasomes Malaria Interleukin 1 Cytokines Macrophages Falciparum Malaria Th17 Cells Parasites Rna Immune System Pathology Inflammation Inbred Cba Mouse Helminths Schistosomiasis Mouse Dectin 2 Dna Pattern Recognition Receptors Plasmodium Molecule Lectin Tensins Toxin Mitogen Receptors Pattern Recognition

Most Recent Publications

The balance between gasdermin D and STING signaling shapes the severity of schistosome immunopathology

Parisa Kalantari, Ilana Shecter, Jacob Hopkins, Andrea Pilotta Gois, Yoelkys Morales, Bijan F. Harandi, Shruti Sharma, Miguel J. Stadecker, 2023, Proceedings of the National Academy of Sciences of the United States of America

STING-dependent type-1 interferon restrains schistosome immunopathology via down-regulation of the CD209a lectin receptor

Parisa Kalantari, 2020, The Journal of Immunology on p. 227.11

The c-type lectin Receptor-Driven, Th17 Cell-Mediated severe pathology in schistosomiasis: Not all immune responses to helminth parasites are Th2 dominated

Parisa Kalantari, Stephen C. Bunnell, Miguel J. Stadecker, 2019, Frontiers in Immunology

Interplay between Plasmodium falciparum haemozoin and l-arginine: Implication for nitric oxide production

Yolanda Corbett, Sarah D'Alessandro, Silvia Parapini, Diletta Scaccabarozzi, Parisa Kalantari, Stefania Zava, Flavio Giavarini, Donatella Caruso, Irma Colombo, Timothy J. Egan, Nicoletta Basilico, 2018, Malaria Journal

The emerging role of pattern recognition receptors in the pathogenesis of Malaria

Parisa Kalantari, 2018, Vaccines

CD209a Synergizes with Dectin-2 and Mincle to Drive Severe Th17 Cell-Mediated Schistosome Egg-Induced Immunopathology

Parisa Kalantari, Yoelkys Morales, Emily A. Miller, Luis D. Jaramillo, Holly E. Ponichtera, Marcel A. Wuethrich, Cheolho Cheong, Maria C. Seminario, Joanne M. Russo, Stephen C. Bunnell, Miguel J. Stadecker, 2018, Cell Reports on p. 1288-1300

MIR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN)

Parisa Kalantari, Omid F. Harandi, Sarika Agarwal, Florentina Rus, Evelyn A. Kurt-Jones, Katherine A. Fitzgerald, Daniel R. Caffrey, Douglas T. Golenbock, 2017, Journal of Biological Chemistry on p. 5634-5644

Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome

Sivapriya Kailasan Vanaja, Vijay A.K. Rathinam, Maninjay K. Atianand, Parisa Kalantari, Brian Skehan, Katherine A. Fitzgerald, John M. Leong, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 7765-7770

RNA and beta;-hemolysin of group B streptococcus induce interleukin-1β (IL-1β) by activating NLRP3 inflammasomes in mouse macrophages

Rahul Gupta, Shubhendu Ghosh, Brian Monks, Rosane B. DeOliveira, Te Chen Tzeng, Parisa Kalantari, Anubhab Nandy, Bornali Bhattacharjee, Jennie Chan, Fabianno Ferreira, Vijay Rathinam, Shruti Sharma, Egil Lien, Neal Silverman, Katherine Fitzgerald, Arnaud Firon, Patrick Trieu-Cuot, Philipp Henneke, Douglas T. Golenbock, 2014, Journal of Biological Chemistry on p. 13701-13705

A Multifactorial Role for P. falciparum Malaria in Endemic Burkitt's Lymphoma Pathogenesis

Charles Torgbor, Peter Awuah, Kirk Deitsch, Parisa Kalantari, Karen A. Duca, David A. Thorley-Lawson, 2014, PLoS Pathogens

Most-Cited Papers

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

Frederick J. Sheedy, Alena Grebe, Katey J. Rayner, Parisa Kalantari, Bhama Ramkhelawon, Susan B. Carpenter, Christine E. Becker, Hasini N. Ediriweera, Adam E. Mullick, Douglas T. Golenbock, Lynda M. Stuart, Eicke Latz, Katherine A. Fitzgerald, Kathryn J. Moore, 2013, Nature Immunology on p. 812-820

Innate sensing of malaria parasites

Ricardo T. Gazzinelli, Parisa Kalantari, Katherine A. Fitzgerald, Douglas T. Golenbock, 2014, Nature Reviews Immunology on p. 744-757

Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during Malaria

Parisa Kalantari, Rosane B. DeOliveira, Jennie Chan, Yolanda Corbett, Vijay Rathinam, Andrea Stutz, Eicke Latz, Ricardo T. Gazzinelli, Douglas T. Golenbock, Katherine A. Fitzgerald, 2014, Cell Reports on p. 196-210