Parisa Kalantari
Assistant Professor of Immunology
-
112 Research Unit A
University Park, PA - puk103@psu.edu
- 814-865-7696
Research Summary
Host-parasite interactions using Schistosoma mansoni-induced liver inflammation in mouse models. Modulation of immune responses by the parasite as well as the role of inflammasomes in inducing schistosomiasis.
Huck Graduate Students
Huck Affiliations
- Molecular, Cellular, and Integrative Biosciences
- Center for Cellular Dynamics
- Center for Malaria Research
Links
Publication Tags
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Malaria Macrophages Inflammasomes Cytokines Interleukin 1 Falciparum Malaria Arginine Nitric Oxide Plasmodium Falciparum Th17 Cells Parasites Rna Immune System Hemozoin Pathology Inbred Cba Mouse Helminths Schistosomiasis Mouse Dectin 2 Dna Plasmodium Molecule Lectin Tensins ToxinMost Recent Publications
The balance between gasdermin D and STING signaling shapes the severity of schistosome immunopathology
Parisa Kalantari, Ilana Shecter, Jacob Hopkins, Andrea Pilotta Gois, Yoelkys Morales, Bijan F. Harandi, Shruti Sharma, Miguel J. Stadecker, 2023, Proceedings of the National Academy of Sciences of the United States of America
STING-dependent type-1 interferon restrains schistosome immunopathology via down-regulation of the CD209a lectin receptor
Parisa Kalantari, 2020, The Journal of Immunology on p. 227.11
The c-type lectin Receptor-Driven, Th17 Cell-Mediated severe pathology in schistosomiasis: Not all immune responses to helminth parasites are Th2 dominated
Parisa Kalantari, Stephen C. Bunnell, Miguel J. Stadecker, 2019, Frontiers in Immunology
Interplay between Plasmodium falciparum haemozoin and l-arginine: Implication for nitric oxide production
Yolanda Corbett, Sarah D'Alessandro, Silvia Parapini, Diletta Scaccabarozzi, Parisa Kalantari, Stefania Zava, Flavio Giavarini, Donatella Caruso, Irma Colombo, Timothy J. Egan, Nicoletta Basilico, 2018, Malaria Journal
The emerging role of pattern recognition receptors in the pathogenesis of Malaria
Parisa Kalantari, 2018, Vaccines
CD209a Synergizes with Dectin-2 and Mincle to Drive Severe Th17 Cell-Mediated Schistosome Egg-Induced Immunopathology
Parisa Kalantari, Yoelkys Morales, Emily A. Miller, Luis D. Jaramillo, Holly E. Ponichtera, Marcel A. Wuethrich, Cheolho Cheong, Maria C. Seminario, Joanne M. Russo, Stephen C. Bunnell, Miguel J. Stadecker, 2018, Cell Reports on p. 1288-1300
MIR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN)
Parisa Kalantari, Omid F. Harandi, Sarika Agarwal, Florentina Rus, Evelyn A. Kurt-Jones, Katherine A. Fitzgerald, Daniel R. Caffrey, Douglas T. Golenbock, 2017, Journal of Biological Chemistry on p. 5634-5644
Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome
Sivapriya Kailasan Vanaja, Vijay A.K. Rathinam, Maninjay K. Atianand, Parisa Kalantari, Brian Skehan, Katherine A. Fitzgerald, John M. Leong, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 7765-7770
RNA and beta;-hemolysin of group B streptococcus induce interleukin-1β (IL-1β) by activating NLRP3 inflammasomes in mouse macrophages
Rahul Gupta, Shubhendu Ghosh, Brian Monks, Rosane B. DeOliveira, Te Chen Tzeng, Parisa Kalantari, Anubhab Nandy, Bornali Bhattacharjee, Jennie Chan, Fabianno Ferreira, Vijay Rathinam, Shruti Sharma, Egil Lien, Neal Silverman, Katherine Fitzgerald, Arnaud Firon, Patrick Trieu-Cuot, Philipp Henneke, Douglas T. Golenbock, 2014, Journal of Biological Chemistry on p. 13701-13705
A Multifactorial Role for P. falciparum Malaria in Endemic Burkitt's Lymphoma Pathogenesis
Charles Torgbor, Peter Awuah, Kirk Deitsch, Parisa Kalantari, Karen A. Duca, David A. Thorley-Lawson, 2014, PLoS Pathogens
Most-Cited Papers
Innate sensing of malaria parasites
Ricardo T. Gazzinelli, Parisa Kalantari, Katherine A. Fitzgerald, Douglas T. Golenbock, 2014, Nature Reviews Immunology on p. 744-757
Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during Malaria
Parisa Kalantari, Rosane B. DeOliveira, Jennie Chan, Yolanda Corbett, Vijay Rathinam, Andrea Stutz, Eicke Latz, Ricardo T. Gazzinelli, Douglas T. Golenbock, Katherine A. Fitzgerald, 2014, Cell Reports on p. 196-210
Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome
Sivapriya Kailasan Vanaja, Vijay A.K. Rathinam, Maninjay K. Atianand, Parisa Kalantari, Brian Skehan, Katherine A. Fitzgerald, John M. Leong, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 7765-7770
A Multifactorial Role for P. falciparum Malaria in Endemic Burkitt's Lymphoma Pathogenesis
Charles Torgbor, Peter Awuah, Kirk Deitsch, Parisa Kalantari, Karen A. Duca, David A. Thorley-Lawson, 2014, PLoS Pathogens
RNA and beta;-hemolysin of group B streptococcus induce interleukin-1β (IL-1β) by activating NLRP3 inflammasomes in mouse macrophages
Rahul Gupta, Shubhendu Ghosh, Brian Monks, Rosane B. DeOliveira, Te Chen Tzeng, Parisa Kalantari, Anubhab Nandy, Bornali Bhattacharjee, Jennie Chan, Fabianno Ferreira, Vijay Rathinam, Shruti Sharma, Egil Lien, Neal Silverman, Katherine Fitzgerald, Arnaud Firon, Patrick Trieu-Cuot, Philipp Henneke, Douglas T. Golenbock, 2014, Journal of Biological Chemistry on p. 13701-13705
MIR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN)
Parisa Kalantari, Omid F. Harandi, Sarika Agarwal, Florentina Rus, Evelyn A. Kurt-Jones, Katherine A. Fitzgerald, Daniel R. Caffrey, Douglas T. Golenbock, 2017, Journal of Biological Chemistry on p. 5634-5644
The emerging role of pattern recognition receptors in the pathogenesis of Malaria
Parisa Kalantari, 2018, Vaccines
The c-type lectin Receptor-Driven, Th17 Cell-Mediated severe pathology in schistosomiasis: Not all immune responses to helminth parasites are Th2 dominated
Parisa Kalantari, Stephen C. Bunnell, Miguel J. Stadecker, 2019, Frontiers in Immunology
CD209a Synergizes with Dectin-2 and Mincle to Drive Severe Th17 Cell-Mediated Schistosome Egg-Induced Immunopathology
Parisa Kalantari, Yoelkys Morales, Emily A. Miller, Luis D. Jaramillo, Holly E. Ponichtera, Marcel A. Wuethrich, Cheolho Cheong, Maria C. Seminario, Joanne M. Russo, Stephen C. Bunnell, Miguel J. Stadecker, 2018, Cell Reports on p. 1288-1300
Interplay between Plasmodium falciparum haemozoin and l-arginine: Implication for nitric oxide production
Yolanda Corbett, Sarah D'Alessandro, Silvia Parapini, Diletta Scaccabarozzi, Parisa Kalantari, Stefania Zava, Flavio Giavarini, Donatella Caruso, Irma Colombo, Timothy J. Egan, Nicoletta Basilico, 2018, Malaria Journal
News Articles Featuring Parisa Kalantari
Nov 21, 2023
College of Ag Sciences recognizes faculty, staff for research achievements
Penn State’s College of Agricultural Sciences lauded outstanding accomplishments in research during the 2023 Research Awards Ceremony, held Nov. 1 at the Hintz Family Alumni Center on the University Park campus.
Full Article
May 04, 2023
Newly discovered immune system mechanism suppresses parasitic infection
Type I interferon, a protein that is important for the body’s defense against viruses, plays a critical role in suppressing inflammation in mice infected with the schistosome parasite, Penn State immunology researchers have found.
Full Article