Nikki Crowley

Assistant Professor of Biology and Biomedical Engineering

Nikki Crowley

Research Summary

Investigation of peptidergic transmission throughout the brain, using cell-specific and pathway-specific manipulations to understand how peptides alter neuronal signaling and behavior, particularly in the context of stress and drug use.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Neurons Anxiety Kappa Opioid Receptor Prefrontal Cortex Dynorphins Basolateral Nuclear Complex Brain Ethanol Somatostatin Septal Nuclei Neuropeptides Glutamic Acid Synaptic Transmission Amygdala Peptides Optogenetics Nucleus Accumbens Alcohols Binge Drinking Anxiolytic Agent Networks (Circuits) Anti Anxiety Agents Depression Corpus Striatum Alcohol Drinking

Most Recent Papers

Somatostatin neurons control an alcohol binge drinking prelimbic microcircuit in mice

Nigel C. Dao, Dakota F. Brockway, Malini Suresh Nair, Avery R. Sicher, Nicole A. Crowley, 2021, Neuropsychopharmacology on p. 1906-1917

Forced Abstinence From Alcohol Induces Sex-Specific Depression-Like Behavioral and Neural Adaptations in Somatostatin Neurons in Cortical and Amygdalar Regions

Nigel C. Dao, Malini Suresh Nair, Sarah N. Magee, J. Brody Moyer, Veronica Sendao, Dakota F. Brockway, Nicole A. Crowley, 2020, Frontiers in Behavioral Neuroscience

Manipulations of central amygdala neurotensin neurons alter the consumption of ethanol and sweet fluids in mice

María Luisa Torruella-Suárez, Jessica R. Vandenberg, Elizabeth S. Cogan, Gregory J. Tipton, Adonay Teklezghi, Kedar Dange, Gunjan K. Patel, Jenna A. McHenry, J. Andrew Hardaway, Pranish A. Kantak, Nicole A. Crowley, Jeffrey F. DiBerto, Sara P. Faccidomo, Clyde W. Hodge, Garret D. Stuber, Zoé A. McElligott, 2020, Journal of Neuroscience on p. 632-647

Turning the ' Tides on Neuropsychiatric Diseases: The Role of Peptides in the Prefrontal Cortex

Dakota F. Brockway, Nicole A. Crowley, 2020, Frontiers in Behavioral Neuroscience

In Vitro Optogenetic Characterization of Neuropeptide Release from Prefrontal Cortical Somatostatin Neurons

Nigel C. Dao, Dakota F. Brockway, Nicole A. Crowley, 2019, Neuroscience on p. 1-4

Reversal of a treatment-resistant, depression-related brain state with the Kv7 channel opener retigabine

Mengyang Feng, Nicole A. Crowley, Akshilkumar Patel, Yao Guo, Sierra E. Bugni, Bernhard Luscher, 2019, Neuroscience on p. 109-125

Ketamine normalizes binge drinking-induced defects in glutamatergic synaptic transmission and ethanol drinking behavior in female but not male mice

Nicole A. Crowley, Sarah N. Magee, Mengyang Feng, Sarah J. Jefferson, Christian J. Morris, Nigel C. Dao, Dakota F. Brockway, Bernhard Luscher, 2019, Neuropharmacology on p. 35-44

Chronic stress dysregulates amygdalar output to the prefrontal cortex

Emily G. Lowery-Gionta, Nicole A. Crowley, Olena Bukalo, Shana Silverstein, Andrew Holmes, Thomas Louis Kash, 2018, Neuropharmacology on p. 68-75

Adolescent social stress increases anxiety-like behavior and alters synaptic transmission, without influencing nicotine responses, in a sex-dependent manner

Michael J. Caruso, Nicole Crowley, Dana E. Reiss, Jasmine I. Caulfield, Bernhard Luscher, Sonia Angele Cavigelli, Helen Marie Kamens, 2018, Neuroscience on p. 182-198

Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit

Nicole A. Crowley, Daniel W. Bloodgood, J. Andrew Hardaway, Alexis M. Kendra, Jordan G. McCall, Ream Al-Hasani, Nora M. McCall, Waylin Yu, Zachary L. Schools, Michael J. Krashes, Bradford B. Lowell, Jennifer L. Whistler, Michael R. Bruchas, Thomas L. Kash, 2016, Cell Reports on p. 2774-2783

Most-Cited Papers

A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior

Eyal Vardy, J. Elliott Robinson, Chia Li, Reid H.J. Olsen, Jeffrey F. DiBerto, Patrick M. Giguere, Flori M. Sassano, Xi Ping Huang, Hu Zhu, Daniel J. Urban, Kate L. White, Joseph E. Rittiner, Nicole A. Crowley, Kristen E. Pleil, Christopher M. Mazzone, Philip D. Mosier, Juan Song, Thomas L. Kash, C. J. Malanga, Michael J. Krashes, Bryan L. Roth, 2015, Neuron on p. 936-946

Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward

Ream Al-Hasani, Jordan G. McCall, Gunchul Shin, Adrian M. Gomez, Gavin P. Schmitz, Julio M. Bernardi, Chang O. Pyo, Sung Il Park, Catherine M. Marcinkiewcz, Nicole A. Crowley, Michael J. Krashes, Bradford B. Lowell, Thomas L. Kash, John A. Rogers, Michael R. Bruchas, 2015, Neuron on p. 1063-1077

Chronic alcohol produces neuroadaptations to prime dorsal striatal learning

Lauren DePoy, Rachel Daut, Jonathan L. Brigman, Kathryn MacPherson, Nicole Crowley, Ozge Gunduz-Cinar, Charles L. Pickens, Resat Cinar, Lisa M. Saksida, George Kunos, David M. Lovinger, Timothy J. Bussey, Marguerite C. Camp, Andrew Holmes, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 14783-14788

LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity

Loukia Parisiadou, Jia Yu, Carmelo Sgobio, Chengsong Xie, Guoxiang Liu, Lixin Sun, Xing Long Gu, Xian Lin, Nicole A. Crowley, David M. Lovinger, Huaibin Cai, 2014, Nature Neuroscience on p. 367-376

Effects of chronic ethanol exposure on neuronal function in the prefrontal cortex and extended amygdala

Kristen E. Pleil, Emily G. Lowery-Gionta, Nicole A. Crowley, Chia Li, Catherine A. Marcinkiewcz, Jamie H. Rose, Nora M. McCall, Antoniette M. Maldonado-Devincci, A. Leslie Morrow, Sara R. Jones, Thomas L. Kash, 2015, Neuropharmacology on p. 735-749

Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit

Nicole A. Crowley, Daniel W. Bloodgood, J. Andrew Hardaway, Alexis M. Kendra, Jordan G. McCall, Ream Al-Hasani, Nora M. McCall, Waylin Yu, Zachary L. Schools, Michael J. Krashes, Bradford B. Lowell, Jennifer L. Whistler, Michael R. Bruchas, Thomas L. Kash, 2016, Cell Reports on p. 2774-2783

Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment

Nicole A. Crowley, Thomas L. Kash, 2015, Progress in Neuro-Psychopharmacology and Biological Psychiatry on p. 51-60

Neuropeptide regulation of signaling and behavior in the BNST

Thomas L. Kash, Kristen E. Pleil, Catherine A. Marcinkiewcz, Emily G. Lowery-Gionta, Nicole Crowley, Christopher Mazzone, Jonathan Sugam, J. Andrew Hardaway, Zoe A. McElligott, 2015, Molecules and Cells on p. 1-13

Glutamatergic mechanisms associated with stress-induced amygdala excitability and anxiety-related behavior

Sophie Masneuf, Emily Lowery-Gionta, Giovanni Colacicco, Kristen E. Pleil, Chia Li, Nicole Crowley, Shaun Flynn, Andrew Holmes, Thomas Kash, 2014, Neuropharmacology on p. 190-197

Chronic stress dysregulates amygdalar output to the prefrontal cortex

Emily G. Lowery-Gionta, Nicole A. Crowley, Olena Bukalo, Shana Silverstein, Andrew Holmes, Thomas Louis Kash, 2018, Neuropharmacology on p. 68-75