Laura Carrel

Associate Professor of Biochemistry and Molecular Biology

Laura Carrel

Research Summary

Genetic, epigenetic, and genomic regulation of expression on the mammalian X chromosome.

Huck Affiliations

Links

Publication Tags

X Chromosome Inactivation Genes X Chromosome Gene Silencing Chromosomes Inactivation Environment Gene Genome Rett Syndrome Chromosome Induced Pluripotent Stem Cells Transgenes Uncertainty Chromatin X Linked Genes Methyl Cpg Binding Protein 2 Disorder Alleles Physiological Sexual Dysfunctions Datasets Rna Loci Gene Expression Phenotype

Most Recent Papers

Inferring genes that escape X-Chromosome inactivation reveals important contribution of variable escape genes to sex-biased diseases

Renan Sauteraud, Jill M. Stahl, Jesica James, Marisa Englebright, Fang Chen, Xiaowei Zhan, Laura Carrel, Dajiang J. Liu, 2021, Genome Research on p. 1629-1637

Prothrombotic variants as modifiers of clinical phenotype in four related individuals with haemophilia A

Laura Carrel, Sarah Arnold-Croop, Ty Achtermann, Fang Chen, Yuhuan Cheng, Dajiang Liu, M. Elaine Eyster, 2021, Haemophilia on p. e591-e595

Investigation of discordant phenotype in mild Hemophilia A using whole exome sequencing

Peter H. Cygan, Sarah E. Arnold-Croop, Elizabeth A. Weidman, Fang Chen, Dajiang J. Liu, M. Elaine Eyster, Laura Carrel, 2020, Thrombosis Research on p. 36-39

When the Lyon(ized chromosome) roars: ongoing expression from an inactive X chromosome

Laura Carrel, Carolyn Brown, 2017, Philosophical Transactions of the Royal Society B: Biological Sciences

Moderate X-chromosome inactivation skewing underlies factor VIII activity in symptomatic carriers from a family with mild haemophilia A

Peter Cygan, Laura Carrel, M. E. Eyster, 2016, Haemophilia on p. e559-e561

Computational and statistical analyses of insertional polymorphic endogenous retroviruses in a non-model organism

Le Bao, Daniel Elleder, Raunaq Malhotra, Michael DeGiorgio, Theodora Maravegias, Lindsay Horvath, Laura Carrel, Colin Gillin, Tomáš Hron, Helena Fábryová, David R. Hunter, Mary Poss, 2014, Computation on p. 221-245

Deletion of an X-Inactivation Boundary Disrupts Adjacent Gene Silencing

Lindsay M. Horvath, Nan Li, Laura Carrel, 2013, PLoS Genetics

X-chromosome inactivation in Rett syndrome human induced pluripotent stem cells

Aaron Y.L. Cheung, Lindsay M. Horvath, Laura Carrel, James Ellis, 2012, Frontiers in Psychiatry

Clustered transcripts that escape X inactivation at mouse XqD

Alexandra M. Lopes, Sarah E. Arnold-Croop, António Amorim, Laura Carrel, 2011, Mammalian Genome on p. 572-582

Genes that escape from X inactivation

Joel B. Berletch, Fan Yang, Jun Xu, Laura Carrel, Christine M. Disteche, 2011, Human Genetics on p. 237-245

Most-Cited Papers

When the Lyon(ized chromosome) roars: ongoing expression from an inactive X chromosome

Laura Carrel, Carolyn Brown, 2017, Philosophical Transactions of the Royal Society B: Biological Sciences

X-chromosome inactivation in Rett syndrome human induced pluripotent stem cells

Aaron Y.L. Cheung, Lindsay M. Horvath, Laura Carrel, James Ellis, 2012, Frontiers in Psychiatry

Deletion of an X-Inactivation Boundary Disrupts Adjacent Gene Silencing

Lindsay M. Horvath, Nan Li, Laura Carrel, 2013, PLoS Genetics

Computational and statistical analyses of insertional polymorphic endogenous retroviruses in a non-model organism

Le Bao, Daniel Elleder, Raunaq Malhotra, Michael DeGiorgio, Theodora Maravegias, Lindsay Horvath, Laura Carrel, Colin Gillin, Tomáš Hron, Helena Fábryová, David R. Hunter, Mary Poss, 2014, Computation on p. 221-245

Moderate X-chromosome inactivation skewing underlies factor VIII activity in symptomatic carriers from a family with mild haemophilia A

Peter Cygan, Laura Carrel, M. E. Eyster, 2016, Haemophilia on p. e559-e561

Investigation of discordant phenotype in mild Hemophilia A using whole exome sequencing

Peter H. Cygan, Sarah E. Arnold-Croop, Elizabeth A. Weidman, Fang Chen, Dajiang J. Liu, M. Elaine Eyster, Laura Carrel, 2020, Thrombosis Research on p. 36-39

Inferring genes that escape X-Chromosome inactivation reveals important contribution of variable escape genes to sex-biased diseases

Renan Sauteraud, Jill M. Stahl, Jesica James, Marisa Englebright, Fang Chen, Xiaowei Zhan, Laura Carrel, Dajiang J. Liu, 2021, Genome Research on p. 1629-1637

Prothrombotic variants as modifiers of clinical phenotype in four related individuals with haemophilia A

Laura Carrel, Sarah Arnold-Croop, Ty Achtermann, Fang Chen, Yuhuan Cheng, Dajiang Liu, M. Elaine Eyster, 2021, Haemophilia on p. e591-e595