Laura Carrel
Associate Professor of Biochemistry and Molecular Biology
-
Hershey Med Ctr
University Park, - luc3@psu.edu
Research Summary
Genetic, epigenetic, and genomic regulation of expression on the mammalian X chromosome.
Huck Affiliations
Links
Publication Tags
Genes X Chromosome Inactivation X Chromosome Gene Silencing Gene Chromosome Inactivation X Linked Genes Chromosomes, Human, X Gene Expression Genomics Genome Transgenes Methyl Cpg Binding Protein 2 Hip Rett Syndrome Uncertainty Mutation Chromosomes Neurons Mammals Sex Chromosomes Chromatin Rna PhenotypeMost Recent Papers
Computational and statistical analyses of insertional polymorphic endogenous retroviruses in a non-model organism
Le Bao, Daniel Elleder, Raunaq Malhotra, Michael DeGiorgio, Theodora Maravegias, Lindsay Horvath, Laura Carrel, Colin Gillin, Tomáš Hron, Helena Fábryová, David Russell Hunter, Mary Poss, 2014, Computation on p. 221-245
Deletion of an X-Inactivation Boundary Disrupts Adjacent Gene Silencing
Lindsay M. Horvath, Nan Li, Laura Carrel, 2013, PLoS Genetics
Clustered transcripts that escape X inactivation at mouse XqD
Alexandra M. Lopes, Sarah E. Arnold-Croop, António Amorim, Laura Carrel, 2011, Mammalian Genome on p. 572-582
Genes that escape from X inactivation
Joel B. Berletch, Fan Yang, Jun Xu, Laura Carrel, Christine M. Disteche, 2011, Human Genetics on p. 237-245
Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation
Aaron Y.L. Cheung, Lindsay M. Horvath, Daria Grafodatskaya, Peter Pasceri, Rosanna Weksberg, Akitsu Hotta, Laura Carrel, James Ellis, 2011, Human Molecular Genetics on p. 2103-2115
Strong purifying selection at genes escaping X chromosome inactivation
Chungoo Park, Laura Carrel, Kateryna D. Makova, 2010, Molecular Biology and Evolution on p. 2446-2450
Escape from X chromosome inactivation is an intrinsic property of the Jarid1c locus
Nan Li, Laura Carrel, 2008, Proceedings of the National Academy of Sciences of the United States of America on p. 17055-17060
Genomic environment predicts expression patterns on the human inactive X chromosome
Laura Carrel, Chungoo Park, Svitlana Tyekucheva, John Dunn, Francesca Chiaromonte, Kateryna D. Makova, 2006, PLoS Genetics on p. 1477-1486
X-inactivation profile reveals extensive variability in X-linked gene expression in females
Laura Carrel, Huntington F. Willard, 2005, Nature on p. 400-404
The DNA sequence of the human X chromosome
Mark T. Ross, Darren V. Grafham, Alison J. Coffey, Steven Scherer, Kirsten McLay, Donna Muzny, Matthias Platzer, Gareth R. Howell, Christine Burrows, Christine P. Bird, Adam Prankish, Frances L. Lovell, Kevin L. Howe, Jennifer L. Ashurst, Robert S. Fulton, Ralf Sudbrak, Gaiping Wen, Matthew C. Jones, Matthew E. Hurles, T. Daniel Andrews, Carol E. Scott, Stephen Searle, Juliane Ramser, Adam Whittaker, Rebecca Deadman, Nigel P. Carter, Sarah E. Hunt, Rui Chen, Andrew Cree, Preethi Gunaratne, Paul Havlak, Anne Hodgson, Michael L. Metzker, Stephen Richards, Graham Scott, David Steffen, Erica Sodergren, David A. Wheeler, Kim C. Worley, Rachael Alnscough, Kerrie D. Ambrose, M. Ali Ansari-Lari, Swaroop Aradhya, Robert I.S. Ashwell, Anne K. Babbage, Claire L. Bagguley, Andrea Ballabio, Ruby Banerjee, Gary E. Barker, Karen F. Barlow, Ian P. Barrett, Karen N. Bates, David M. Beare, Helen Beasley, Oliver Beasley, Alfred Beck, Graeme Bethel, Karin Blechschmidt, Nicola Brady, Sarah Bray-Allen, Anne M. Bridgeman, Andrew J. Brown, Mary J. Brown, David Bonnin, Elspeth A. Bruford, Christian Buhay, Paula Burch, Deborah Burford, Joanne Burgess, Wayne Burrill, John Burton, Jackie M. Bye, Carol Carder, Laura Carrel, Joseph Chako, Joanne C. Chapman, Dean Chavez, Ellson Chen, Guan Chen, Yuan Chen, Zhijian Chen, Craig Chinault, Alfredo Ciccodicola, Sue Y. Clark, Graham Clarke, Chris M. Clee, Sheila Clegg, Kerstin Clerc-Blankenburg, Karen Clifford, Vicky Cobley, Charlotte G. Cole, Jen S. Conquer, Nicole Corby, Richard E. Connor, Robert David, Joy Davies, Clay Davis, John Davis, Oliver Delgado, Denise DeShazo, Pawandeep Dhami, Yan Ding, Huyen Dinh, Steve Dodsworth, Heather Draper, Shannon Dugan-Rocha, Andrew Dunham, Matthew Dunn, K. James Durbin, Ireena Dutta, Tamsin Eades, Matthew Ellwood, Alexandra Emery-Cohen, Helen Errington, Kathryn L. Evans, Louisa Faulkner, Fiona Francis, John Frankland, Audrey E. Fraser, Petra Galgoczy, James Gilbert, Rachel Gill, Gernot Glöckner, Simon G. Gregory, Susan Gribble, Coline Griffiths, Russell Grocock, Yanghong Gu, Rhian Gwilliam, Cerissa Hamilton, Elizabeth A. Hart, Alicia Hawes, Paul D. Heath, Katja Heitmann, Steffen Hennig, Judith Hernandez, Bernd Hinzmann, Sarah Ho, Michael Hoffs, Phillip J. Howden, Elizabeth J. Huckle, Jennifer Hume, Paul J. Hunt, Adrienne R. Hunt, Judith Isherwood, Leni Jacob, David Johnson, Sally Jones, Pieter J. De Jong, Shirin S. Joseph, Stephen Keenan, Susan Kelly, Joanne K. Kershaw, Ziad Khan, Petra Kloschis, Sven Klages, Andrew J. Knights, Anna Kosiura, Christie Kovar-Smith, Gavin K. Laird, Cordelia Langford, Stephanie Lawlor, Margaret Leversha, Lora Lewis, Wen Liu, Christine Lloyd, David M. Lloyd, Hermela Loulseged, Jane E. Loveland, Jamieson D. Lovell, Ryan Lozado, Jing Lu, Rachael Lyne, Jie Ma, Manjula Maheshwari, Lucy H. Matthews, Jennifer McDowall, Stuart McLaren, Amanda McMurray, Patrick Meidl, Thomas Meitinger, Sarah Milne, George Miner, Shailesh L. Mistry, Margaret Morgan, Sidney Morris, Ines Müller, James C. Mullikin, Ngoc Nguyen, Gabriele Nordsiek, Gerald Nyakatura, Christopher N. O'Dell, Geoffery Okwuonu, Sophie Palmer, Richard Pandian, David Parker, Julia Parrish, Shiran Pasternak, Dina Patel, Alex V. Pearce, Danita M. Pearson, Sarah E. Pelan, Lesette Perez, Keith M. Porter, Yvonne Ramsey, Kathrin Reichwald, Susan Rhodes, Kerry A. Ridler, David Schlessinger, Mary G. Schueler, Harminder K. Sehra, Charles Shaw-Smith, Hua Shen, Elizabeth M. Sheridan, Ratna Shownkeen, Carl D. Skuce, Michelle L. Smith, Elizabeth C. Sotheran, Helen E. Steingruber, Charles A. Steward, Roy Storey, R. Mark Swann, David Swarbreck, Paul E. Tabor, Stefan Taudien, Tineace Taylor, Brian Teague, Karen Thomas, Andrea Thorpe, Kirsten Timms, Alan Tracey, Steve Trevanion, Anthony C. Tromans, Michele D'Urso, Daniel Verduzco, Donna Villasana, Lenee Waldron, Melanie Wall, Qiaoyan Wang, James Warren, Georgina L. Warry, Xuehong Wei, Anthony West, Siobhan L. Whitehead, Mathew N. Whiteley, Jane E. Wilkinson, David L. Willey, Gabrielle Williams, Leanne Williams, Angela Williamson, Helen Williamson, Laurens Wilming, Rebecca L. Woodmansey, Paul W. Wray, Jennifer Yen, Jingkun Zhang, Jianling Zhou, Huda Zoghbi, Sara Zorilla, David Buck, Richard Reinhardt, Annemarie Poustka, André Rosenthal, Hans Lehrach, Alfons Meindl, Patrick J. Minx, La Deana W. Hillier, Huntington F. Willard, Richard K. Wilson, Robert H. Waterston, Catherine M. Rice, Mark Vaudin, Alan Coulson, David L. Nelson, George Weinstock, John E. Sulston, Richard Durbin, Tim Hubbard, Richard A. Gibbs, Stephan Beck, Jane Rogers, David R. Bentley, 2005, Nature on p. 325-337
Most-Cited Papers
Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation
Aaron Y.L. Cheung, Lindsay M. Horvath, Daria Grafodatskaya, Peter Pasceri, Rosanna Weksberg, Akitsu Hotta, Laura Carrel, James Ellis, 2011, Human Molecular Genetics on p. 2103-2115
Genes that escape from X inactivation
Joel B. Berletch, Fan Yang, Jun Xu, Laura Carrel, Christine M. Disteche, 2011, Human Genetics on p. 237-245
Deletion of an X-Inactivation Boundary Disrupts Adjacent Gene Silencing
Lindsay M. Horvath, Nan Li, Laura Carrel, 2013, PLoS Genetics
Clustered transcripts that escape X inactivation at mouse XqD
Alexandra M. Lopes, Sarah E. Arnold-Croop, António Amorim, Laura Carrel, 2011, Mammalian Genome on p. 572-582
Computational and statistical analyses of insertional polymorphic endogenous retroviruses in a non-model organism
Le Bao, Daniel Elleder, Raunaq Malhotra, Michael DeGiorgio, Theodora Maravegias, Lindsay Horvath, Laura Carrel, Colin Gillin, Tomáš Hron, Helena Fábryová, David Russell Hunter, Mary Poss, 2014, Computation on p. 221-245
When the Lyon(ized chromosome) roars: ongoing expression from an inactive X chromosome
Laura Carrel, Carolyn Brown, 2017, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES