Laura Carrel
Professor of Biochemistry and Molecular Biology
-
Hershey Med Ctr
University Park, - luc3@psu.edu
Research Summary
Genetic, epigenetic, and genomic regulation of expression on the mammalian X chromosome.
Huck Affiliations
Links
Publication Tags
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Genes Chromatin X Chromosome Chromosomes Drugs Drug X Chromosome Inactivation Predictions Autoimmune Diseases Genome Drug Repositioning Transcriptome Genome Wide Association Study Epigenomics Systemic Lupus Erythematosus Cells Inactivation Genetic Association Studies Environment Meta Analysis Loci Monocytes Biomarkers Gene Expression InhibitorsMost Recent Publications
Integrating summary statistics of expression quantitative trait loci from single cell RNASeq data to understand cell type specific effects for complex traits
Lida Wang, Chakrit Khunsriraksakul, Havell Markus, Xingyan Wang, Fang Chen, Laura Carrel, Dajiang Liu, Bibo Jiang, Nature Communications
Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus
C Khunsriraksakul, Q Li, H Markus, M Patrick, R Sauteraud, D McGuire, Xingyan Wang, C Wang, L Wang, S Chen, G Shenoy, B Li, X Zhong, Nancy J. Olsen, Laura Carrel, L Tsoi, Bibo Jiang, Dajiang J. Liu, 2023, Nature Communications on p. 668
Construction and Application of Polygenic Risk Scores in Autoimmune Diseases
C Khunsriraksakul, H Markus, Nancy J. Olsen, Laura Carrel, Bibo Jiang, Dajiang J. Liu, 2022, Frontiers in Immunology on p. 889296
Integrating 3D genomic and epigenomic data to enhance target gene discovery and drug repurposing in transcriptome-wide association studies
C Khunsriraksakul, D McGuire, R Sauteraud, F Chen, L Yang, L Wang, J Hughey, S Eckert, J Dylan Weissenkampen, G Shenoy, O Marx, Laura Carrel, Bibo Jiang, Dajiang J. Liu, 2022, Nature Communications on p. 3258
Inferring genes that escape X-Chromosome inactivation reveals important contribution of variable escape genes to sex-biased diseases
Renan Sauteraud, Jill M. Stahl, Jesica James, Marisa Englebright, Fang Chen, Xiaowei Zhan, Laura Carrel, Dajiang J. Liu, 2021, Genome Research on p. 1629-1637
Prothrombotic variants as modifiers of clinical phenotype in four related individuals with haemophilia A
Laura Carrel, Sarah Arnold-Croop, Ty Achtermann, Fang Chen, Yuhuan Cheng, Dajiang Liu, M. Elaine Eyster, 2021, Haemophilia on p. e591-e595
Diagnosing Dehydrated Hereditary Stomatocytosis due to a KCNN4 Gardos Channel Mutation: Understanding Challenges through Study of a Multi-Generational Family
S Waldstein, S Arnold-Croop, Laura Carrel, M Eyster, 2021, EJHaem on p. 485-487
Investigation of discordant phenotype in mild Hemophilia A using whole exome sequencing
Peter H. Cygan, Sarah E. Arnold-Croop, Elizabeth A. Weidman, Fang Chen, Dajiang J. Liu, M. Elaine Eyster, Laura Carrel, 2020, Thrombosis Research on p. 36-39
When the lyon(Ized chromosome) roars: Ongoing expression from an inactive X chromosome
Laura Carrel, Carolyn Brown, 2017, Philosophical Transactions of the Royal Society B: Biological Sciences
Moderate X-chromosome inactivation skewing underlies factor VIII activity in symptomatic carriers from a family with mild haemophilia A
Peter Cygan, Laura Carrel, M. E. Eyster, 2016, Haemophilia on p. e559-e561
Most-Cited Papers
When the lyon(Ized chromosome) roars: Ongoing expression from an inactive X chromosome
Laura Carrel, Carolyn Brown, 2017, Philosophical Transactions of the Royal Society B: Biological Sciences
Inferring genes that escape X-Chromosome inactivation reveals important contribution of variable escape genes to sex-biased diseases
Renan Sauteraud, Jill M. Stahl, Jesica James, Marisa Englebright, Fang Chen, Xiaowei Zhan, Laura Carrel, Dajiang J. Liu, 2021, Genome Research on p. 1629-1637
Integrating 3D genomic and epigenomic data to enhance target gene discovery and drug repurposing in transcriptome-wide association studies
C Khunsriraksakul, D McGuire, R Sauteraud, F Chen, L Yang, L Wang, J Hughey, S Eckert, J Dylan Weissenkampen, G Shenoy, O Marx, Laura Carrel, Bibo Jiang, Dajiang J. Liu, 2022, Nature Communications on p. 3258
Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus
C Khunsriraksakul, Q Li, H Markus, M Patrick, R Sauteraud, D McGuire, Xingyan Wang, C Wang, L Wang, S Chen, G Shenoy, B Li, X Zhong, Nancy J. Olsen, Laura Carrel, L Tsoi, Bibo Jiang, Dajiang J. Liu, 2023, Nature Communications on p. 668
Construction and Application of Polygenic Risk Scores in Autoimmune Diseases
C Khunsriraksakul, H Markus, Nancy J. Olsen, Laura Carrel, Bibo Jiang, Dajiang J. Liu, 2022, Frontiers in Immunology on p. 889296
Computational and statistical analyses of insertional polymorphic endogenous retroviruses in a non-model organism
Le Bao, Daniel Elleder, Raunaq Malhotra, Michael DeGiorgio, Theodora Maravegias, Lindsay Horvath, Laura Carrel, Colin Gillin, Tomáš Hron, Helena Fábryová, David R. Hunter, Mary Poss, 2014, Computation on p. 221-245
Moderate X-chromosome inactivation skewing underlies factor VIII activity in symptomatic carriers from a family with mild haemophilia A
Peter Cygan, Laura Carrel, M. E. Eyster, 2016, Haemophilia on p. e559-e561
Investigation of discordant phenotype in mild Hemophilia A using whole exome sequencing
Peter H. Cygan, Sarah E. Arnold-Croop, Elizabeth A. Weidman, Fang Chen, Dajiang J. Liu, M. Elaine Eyster, Laura Carrel, 2020, Thrombosis Research on p. 36-39
Prothrombotic variants as modifiers of clinical phenotype in four related individuals with haemophilia A
Laura Carrel, Sarah Arnold-Croop, Ty Achtermann, Fang Chen, Yuhuan Cheng, Dajiang Liu, M. Elaine Eyster, 2021, Haemophilia on p. e591-e595
Diagnosing Dehydrated Hereditary Stomatocytosis due to a KCNN4 Gardos Channel Mutation: Understanding Challenges through Study of a Multi-Generational Family
S Waldstein, S Arnold-Croop, Laura Carrel, M Eyster, 2021, EJHaem on p. 485-487
News Articles Featuring Laura Carrel
Jun 12, 2023
Penn State announces tenure-line faculty promotions, effective July 1, 2023
The following is a list of academic promotions for tenured and tenure-line faculty members at Penn State, effective July 1, 2023.
Full Article
Jun 28, 2022
New machine learning technique shows how drugs can be repurposed
A new machine learning method to model gene expression levels might improve the identification of genes that cause human diseases, according to a new study by Penn State College of Medicine researchers.
Full Article
Sep 07, 2021
New tool reveals genetic influence of some sex-biased diseases, including lupus
Many human diseases can differ between males and females in their prevalence, manifestation, severity or age of onset. Examples include Lupus, where more than 80% of patients are females; Alzheimer’s disease, where females have higher incidence and tend to suffer quicker cognitive decline; and COVID-19 infections that are frequently more severe in males.
Full Article