Laura Carrel
Associate Professor of Biochemistry and Molecular Biology
-
Hershey Med Ctr
University Park, - luc3@psu.edu
Research Summary
Genetic, epigenetic, and genomic regulation of expression on the mammalian X chromosome.
Huck Affiliations
Links
Publication Tags
X Chromosome Inactivation Genes X Chromosome Chromosomes Inactivation Gene Silencing Rett Syndrome Methyl Cpg Binding Protein 2 Gene Chromosome Induced Pluripotent Stem Cells Hip Genome Chromatin X Linked Genes Neurons Transgenes Gene Expression Uncertainty Mutation Alleles Mammals Dosage Phenotype Cell LineMost Recent Papers
Investigation of discordant phenotype in mild Hemophilia A using whole exome sequencing
Peter H. Cygan, Sarah E. Arnold-Croop, Elizabeth A. Weidman, Fang Chen, Dajiang J. Liu, M. Elaine Eyster, Laura Carrel, 2020, Thrombosis Research on p. 36-39
When the lyon(Ized chromosome) roars
Laura Carrel, Carolyn J. Brown, 2017, Philosophical Transactions of the Royal Society B: Biological Sciences
Moderate X-chromosome inactivation skewing underlies factor VIII activity in symptomatic carriers from a family with mild haemophilia A
Peter Cygan, Laura Carrel, M. E. Eyster, 2016, Haemophilia on p. e559-e561
Computational and statistical analyses of insertional polymorphic endogenous retroviruses in a non-model organism
Le Bao, Daniel Elleder, Raunaq Malhotra, Michael DeGiorgio, Theodora Maravegias, Lindsay Horvath, Laura Carrel, Colin Gillin, Tomáš Hron, Helena Fábryová, David Russell Hunter, Mary Poss, 2014, Computation on p. 221-245
Deletion of an X-Inactivation Boundary Disrupts Adjacent Gene Silencing
Lindsay M. Horvath, Nan Li, Laura Carrel, 2013, PLoS Genetics
X-chromosome inactivation in Rett syndrome human induced pluripotent stem cells
Aaron Y.L. Cheung, Lindsay M. Horvath, Laura Carrel, James Ellis, 2012, Frontiers in Psychiatry
Clustered transcripts that escape X inactivation at mouse XqD
Alexandra M. Lopes, Sarah E. Arnold-Croop, António Amorim, Laura Carrel, 2011, Mammalian Genome on p. 572-582
Genes that escape from X inactivation
Joel B. Berletch, Fan Yang, Jun Xu, Laura Carrel, Christine M. Disteche, 2011, Human Genetics on p. 237-245
Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation
Aaron Y.L. Cheung, Lindsay M. Horvath, Daria Grafodatskaya, Peter Pasceri, Rosanna Weksberg, Akitsu Hotta, Laura Carrel, James Ellis, 2011, Human Molecular Genetics on p. 2103-2115
Strong purifying selection at genes escaping X chromosome inactivation
Chungoo Park, Laura Carrel, Kateryna D. Makova, 2010, Molecular Biology and Evolution on p. 2446-2450
Most-Cited Papers
Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation
Aaron Y.L. Cheung, Lindsay M. Horvath, Daria Grafodatskaya, Peter Pasceri, Rosanna Weksberg, Akitsu Hotta, Laura Carrel, James Ellis, 2011, Human Molecular Genetics on p. 2103-2115
Genes that escape from X inactivation
Joel B. Berletch, Fan Yang, Jun Xu, Laura Carrel, Christine M. Disteche, 2011, Human Genetics on p. 237-245
X-chromosome inactivation in Rett syndrome human induced pluripotent stem cells
Aaron Y.L. Cheung, Lindsay M. Horvath, Laura Carrel, James Ellis, 2012, Frontiers in Psychiatry
When the lyon(Ized chromosome) roars
Laura Carrel, Carolyn J. Brown, 2017, Philosophical Transactions of the Royal Society B: Biological Sciences
Deletion of an X-Inactivation Boundary Disrupts Adjacent Gene Silencing
Lindsay M. Horvath, Nan Li, Laura Carrel, 2013, PLoS Genetics
Clustered transcripts that escape X inactivation at mouse XqD
Alexandra M. Lopes, Sarah E. Arnold-Croop, António Amorim, Laura Carrel, 2011, Mammalian Genome on p. 572-582
Computational and statistical analyses of insertional polymorphic endogenous retroviruses in a non-model organism
Le Bao, Daniel Elleder, Raunaq Malhotra, Michael DeGiorgio, Theodora Maravegias, Lindsay Horvath, Laura Carrel, Colin Gillin, Tomáš Hron, Helena Fábryová, David Russell Hunter, Mary Poss, 2014, Computation on p. 221-245
Moderate X-chromosome inactivation skewing underlies factor VIII activity in symptomatic carriers from a family with mild haemophilia A
Peter Cygan, Laura Carrel, M. E. Eyster, 2016, Haemophilia on p. e559-e561
Investigation of discordant phenotype in mild Hemophilia A using whole exome sequencing
Peter H. Cygan, Sarah E. Arnold-Croop, Elizabeth A. Weidman, Fang Chen, Dajiang J. Liu, M. Elaine Eyster, Laura Carrel, 2020, Thrombosis Research on p. 36-39