Laura Carrel

Associate Professor of Biochemistry and Molecular Biology

Laura Carrel

Research Summary

Genetic, epigenetic, and genomic regulation of expression on the mammalian X chromosome.

Huck Affiliations

Links

Publication Tags

X Chromosome Inactivation Genes Gene Silencing X Chromosome Rett Syndrome Gene Inactivation Methyl Cpg Binding Protein 2 Chromosome Induced Pluripotent Stem Cells Hip Genome X Linked Genes Neurons Transgenes Gene Expression Uncertainty Mutation Alleles Chromosomes Mammals Phenotype Exons Cell Line Loci

Most Recent Papers

Investigation of discordant phenotype in mild Hemophilia A using whole exome sequencing

Peter H. Cygan, Sarah E. Arnold-Croop, Elizabeth A. Weidman, Fang Chen, Dajiang J. Liu, M. Elaine Eyster, Laura Carrel, 2020, Thrombosis Research on p. 36-39

When the Lyon(ized chromosome) roars: ongoing expression from an inactive X chromosome

Laura Carrel, Carolyn Brown, 2017, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Moderate X-chromosome inactivation skewing underlies factor VIII activity in symptomatic carriers from a family with mild haemophilia A

Peter Cygan, Laura Carrel, M. E. Eyster, 2016, Haemophilia on p. e559-e561

Computational and statistical analyses of insertional polymorphic endogenous retroviruses in a non-model organism

Le Bao, Daniel Elleder, Raunaq Malhotra, Michael DeGiorgio, Theodora Maravegias, Lindsay Horvath, Laura Carrel, Colin Gillin, Tomáš Hron, Helena Fábryová, David R. Hunter, Mary Poss, 2014, Computation on p. 221-245

Deletion of an X-Inactivation Boundary Disrupts Adjacent Gene Silencing

Lindsay M. Horvath, Nan Li, Laura Carrel, 2013, PLoS Genetics

X-chromosome inactivation in Rett syndrome human induced pluripotent stem cells

Aaron Y.L. Cheung, Lindsay M. Horvath, Laura Carrel, James Ellis, 2012, Frontiers in Psychiatry

Clustered transcripts that escape X inactivation at mouse XqD

Alexandra M. Lopes, Sarah E. Arnold-Croop, António Amorim, Laura Carrel, 2011, Mammalian Genome on p. 572-582

Genes that escape from X inactivation

Joel B. Berletch, Fan Yang, Jun Xu, Laura Carrel, Christine M. Disteche, 2011, Human Genetics on p. 237-245

Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation

Aaron Y.L. Cheung, Lindsay M. Horvath, Daria Grafodatskaya, Peter Pasceri, Rosanna Weksberg, Akitsu Hotta, Laura Carrel, James Ellis, 2011, Human Molecular Genetics on p. 2103-2115

Strong purifying selection at genes escaping X chromosome inactivation

Chungoo Park, Laura Carrel, Kateryna D. Makova, 2010, Molecular Biology and Evolution on p. 2446-2450

Most-Cited Papers

Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation

Aaron Y.L. Cheung, Lindsay M. Horvath, Daria Grafodatskaya, Peter Pasceri, Rosanna Weksberg, Akitsu Hotta, Laura Carrel, James Ellis, 2011, Human Molecular Genetics on p. 2103-2115

Genes that escape from X inactivation

Joel B. Berletch, Fan Yang, Jun Xu, Laura Carrel, Christine M. Disteche, 2011, Human Genetics on p. 237-245

X-chromosome inactivation in Rett syndrome human induced pluripotent stem cells

Aaron Y.L. Cheung, Lindsay M. Horvath, Laura Carrel, James Ellis, 2012, Frontiers in Psychiatry

Deletion of an X-Inactivation Boundary Disrupts Adjacent Gene Silencing

Lindsay M. Horvath, Nan Li, Laura Carrel, 2013, PLoS Genetics

Clustered transcripts that escape X inactivation at mouse XqD

Alexandra M. Lopes, Sarah E. Arnold-Croop, António Amorim, Laura Carrel, 2011, Mammalian Genome on p. 572-582

Computational and statistical analyses of insertional polymorphic endogenous retroviruses in a non-model organism

Le Bao, Daniel Elleder, Raunaq Malhotra, Michael DeGiorgio, Theodora Maravegias, Lindsay Horvath, Laura Carrel, Colin Gillin, Tomáš Hron, Helena Fábryová, David R. Hunter, Mary Poss, 2014, Computation on p. 221-245

Moderate X-chromosome inactivation skewing underlies factor VIII activity in symptomatic carriers from a family with mild haemophilia A

Peter Cygan, Laura Carrel, M. E. Eyster, 2016, Haemophilia on p. e559-e561

Investigation of discordant phenotype in mild Hemophilia A using whole exome sequencing

Peter H. Cygan, Sarah E. Arnold-Croop, Elizabeth A. Weidman, Fang Chen, Dajiang J. Liu, M. Elaine Eyster, Laura Carrel, 2020, Thrombosis Research on p. 36-39

When the Lyon(ized chromosome) roars: ongoing expression from an inactive X chromosome

Laura Carrel, Carolyn Brown, 2017, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES