Laura Carrel
Associate Professor of Biochemistry and Molecular Biology
-
Hershey Med Ctr
University Park, - luc3@psu.edu
Research Summary
Genetic, epigenetic, and genomic regulation of expression on the mammalian X chromosome.
Huck Affiliations
Links
Publication Tags
Genes X Chromosome X Chromosome Inactivation Chromatin Gene Silencing Chromosomes Inactivation Epigenomics Genetic Association Studies Gene Drugs Environment Genome Drug Repositioning Autoimmune Diseases Chromosome Transcriptome Drug Predictions Transgenes Gene Expression Uncertainty Loci Disorder Physiological Sexual DysfunctionsMost Recent Publications
Integrating 3D genomic and epigenomic data to enhance target gene discovery and drug repurposing in transcriptome-wide association studies
Chachrit Khunsriraksakul, Daniel McGuire, Renan Sauteraud, Fang Chen, Lina Yang, Lida Wang, Jordan Hughey, Scott Eckert, J. Dylan Weissenkampen, Ganesh Shenoy, Olivia Marx, Laura Carrel, Bibo Jiang, Dajiang J. Liu, 2022, Nature Communications
Construction and Application of Polygenic Risk Scores in Autoimmune Diseases
Chachrit Khunsriraksakul, Havell Markus, Nancy J. Olsen, Laura Carrel, Bibo Jiang, Dajiang J. Liu, 2022, Frontiers in Immunology
Inferring genes that escape X-Chromosome inactivation reveals important contribution of variable escape genes to sex-biased diseases
Renan Sauteraud, Jill M. Stahl, Jesica James, Marisa Englebright, Fang Chen, Xiaowei Zhan, Laura Carrel, Dajiang J. Liu, 2021, Genome Research on p. 1629-1637
Prothrombotic variants as modifiers of clinical phenotype in four related individuals with haemophilia A
Laura Carrel, Sarah Arnold-Croop, Ty Achtermann, Fang Chen, Yuhuan Cheng, Dajiang Liu, M. Elaine Eyster, 2021, Haemophilia on p. e591-e595
Diagnosing Dehydrated Hereditary Stomatocytosis due to a KCNN4 Gardos Channel Mutation: Understanding Challenges through Study of a Multi-Generational Family
S Waldstein, S Arnold-Croop, Laura Carrel, M Eyster, 2021, EJHaem on p. 485-487
Investigation of discordant phenotype in mild Hemophilia A using whole exome sequencing
Peter H. Cygan, Sarah E. Arnold-Croop, Elizabeth A. Weidman, Fang Chen, Dajiang J. Liu, M. Elaine Eyster, Laura Carrel, 2020, Thrombosis Research on p. 36-39
When the lyon(Ized chromosome) roars: Ongoing expression from an inactive X chromosome
Laura Carrel, Carolyn Brown, 2017, Philosophical Transactions of the Royal Society B: Biological Sciences
Moderate X-chromosome inactivation skewing underlies factor VIII activity in symptomatic carriers from a family with mild haemophilia A
Peter Cygan, Laura Carrel, M. E. Eyster, 2016, Haemophilia on p. e559-e561
Computational and statistical analyses of insertional polymorphic endogenous retroviruses in a non-model organism
Le Bao, Daniel Elleder, Raunaq Malhotra, Michael DeGiorgio, Theodora Maravegias, Lindsay Horvath, Laura Carrel, Colin Gillin, Tomáš Hron, Helena Fábryová, David R. Hunter, Mary Poss, 2014, Computation on p. 221-245
Deletion of an X-Inactivation Boundary Disrupts Adjacent Gene Silencing
Lindsay M. Horvath, Nan Li, Laura Carrel, 2013, PLoS Genetics
Most-Cited Papers
When the lyon(Ized chromosome) roars: Ongoing expression from an inactive X chromosome
Laura Carrel, Carolyn Brown, 2017, Philosophical Transactions of the Royal Society B: Biological Sciences
Deletion of an X-Inactivation Boundary Disrupts Adjacent Gene Silencing
Lindsay M. Horvath, Nan Li, Laura Carrel, 2013, PLoS Genetics
Computational and statistical analyses of insertional polymorphic endogenous retroviruses in a non-model organism
Le Bao, Daniel Elleder, Raunaq Malhotra, Michael DeGiorgio, Theodora Maravegias, Lindsay Horvath, Laura Carrel, Colin Gillin, Tomáš Hron, Helena Fábryová, David R. Hunter, Mary Poss, 2014, Computation on p. 221-245
Inferring genes that escape X-Chromosome inactivation reveals important contribution of variable escape genes to sex-biased diseases
Renan Sauteraud, Jill M. Stahl, Jesica James, Marisa Englebright, Fang Chen, Xiaowei Zhan, Laura Carrel, Dajiang J. Liu, 2021, Genome Research on p. 1629-1637
Moderate X-chromosome inactivation skewing underlies factor VIII activity in symptomatic carriers from a family with mild haemophilia A
Peter Cygan, Laura Carrel, M. E. Eyster, 2016, Haemophilia on p. e559-e561
Investigation of discordant phenotype in mild Hemophilia A using whole exome sequencing
Peter H. Cygan, Sarah E. Arnold-Croop, Elizabeth A. Weidman, Fang Chen, Dajiang J. Liu, M. Elaine Eyster, Laura Carrel, 2020, Thrombosis Research on p. 36-39
Construction and Application of Polygenic Risk Scores in Autoimmune Diseases
Chachrit Khunsriraksakul, Havell Markus, Nancy J. Olsen, Laura Carrel, Bibo Jiang, Dajiang J. Liu, 2022, Frontiers in Immunology
Prothrombotic variants as modifiers of clinical phenotype in four related individuals with haemophilia A
Laura Carrel, Sarah Arnold-Croop, Ty Achtermann, Fang Chen, Yuhuan Cheng, Dajiang Liu, M. Elaine Eyster, 2021, Haemophilia on p. e591-e595
Integrating 3D genomic and epigenomic data to enhance target gene discovery and drug repurposing in transcriptome-wide association studies
Chachrit Khunsriraksakul, Daniel McGuire, Renan Sauteraud, Fang Chen, Lina Yang, Lida Wang, Jordan Hughey, Scott Eckert, J. Dylan Weissenkampen, Ganesh Shenoy, Olivia Marx, Laura Carrel, Bibo Jiang, Dajiang J. Liu, 2022, Nature Communications
Diagnosing Dehydrated Hereditary Stomatocytosis due to a KCNN4 Gardos Channel Mutation: Understanding Challenges through Study of a Multi-Generational Family
S Waldstein, S Arnold-Croop, Laura Carrel, M Eyster, 2021, EJHaem on p. 485-487
News Articles Featuring Laura Carrel
Jun 28, 2022
New machine learning technique shows how drugs can be repurposed
A new machine learning method to model gene expression levels might improve the identification of genes that cause human diseases, according to a new study by Penn State College of Medicine researchers.
Full Article
Sep 07, 2021
New tool reveals genetic influence of some sex-biased diseases, including lupus
Many human diseases can differ between males and females in their prevalence, manifestation, severity or age of onset. Examples include Lupus, where more than 80% of patients are females; Alzheimer’s disease, where females have higher incidence and tend to suffer quicker cognitive decline; and COVID-19 infections that are frequently more severe in males.
Full Article