Laura Carrel
Associate Professor of Biochemistry and Molecular Biology
-
Hershey Med Ctr
University Park, - luc3@psu.edu
Research Summary
Genetic, epigenetic, and genomic regulation of expression on the mammalian X chromosome.
Huck Affiliations
Links
Publication Tags
X Chromosome Inactivation Genes X Chromosome Gene Silencing Chromosomes Inactivation Environment Gene Genome Rett Syndrome Chromosome Induced Pluripotent Stem Cells Transgenes Uncertainty Chromatin X Linked Genes Methyl Cpg Binding Protein 2 Disorder Alleles Physiological Sexual Dysfunctions Datasets Rna Loci Gene Expression PhenotypeMost Recent Papers
Inferring genes that escape X-Chromosome inactivation reveals important contribution of variable escape genes to sex-biased diseases
Renan Sauteraud, Jill M. Stahl, Jesica James, Marisa Englebright, Fang Chen, Xiaowei Zhan, Laura Carrel, Dajiang J. Liu, 2021, Genome Research on p. 1629-1637
Prothrombotic variants as modifiers of clinical phenotype in four related individuals with haemophilia A
Laura Carrel, Sarah Arnold-Croop, Ty Achtermann, Fang Chen, Yuhuan Cheng, Dajiang Liu, M. Elaine Eyster, 2021, Haemophilia on p. e591-e595
Investigation of discordant phenotype in mild Hemophilia A using whole exome sequencing
Peter H. Cygan, Sarah E. Arnold-Croop, Elizabeth A. Weidman, Fang Chen, Dajiang J. Liu, M. Elaine Eyster, Laura Carrel, 2020, Thrombosis Research on p. 36-39
When the Lyon(ized chromosome) roars: ongoing expression from an inactive X chromosome
Laura Carrel, Carolyn Brown, 2017, Philosophical Transactions of the Royal Society B: Biological Sciences
Moderate X-chromosome inactivation skewing underlies factor VIII activity in symptomatic carriers from a family with mild haemophilia A
Peter Cygan, Laura Carrel, M. E. Eyster, 2016, Haemophilia on p. e559-e561
Computational and statistical analyses of insertional polymorphic endogenous retroviruses in a non-model organism
Le Bao, Daniel Elleder, Raunaq Malhotra, Michael DeGiorgio, Theodora Maravegias, Lindsay Horvath, Laura Carrel, Colin Gillin, Tomáš Hron, Helena Fábryová, David R. Hunter, Mary Poss, 2014, Computation on p. 221-245
Deletion of an X-Inactivation Boundary Disrupts Adjacent Gene Silencing
Lindsay M. Horvath, Nan Li, Laura Carrel, 2013, PLoS Genetics
X-chromosome inactivation in Rett syndrome human induced pluripotent stem cells
Aaron Y.L. Cheung, Lindsay M. Horvath, Laura Carrel, James Ellis, 2012, Frontiers in Psychiatry
Clustered transcripts that escape X inactivation at mouse XqD
Alexandra M. Lopes, Sarah E. Arnold-Croop, António Amorim, Laura Carrel, 2011, Mammalian Genome on p. 572-582
Genes that escape from X inactivation
Joel B. Berletch, Fan Yang, Jun Xu, Laura Carrel, Christine M. Disteche, 2011, Human Genetics on p. 237-245
Most-Cited Papers
When the Lyon(ized chromosome) roars: ongoing expression from an inactive X chromosome
Laura Carrel, Carolyn Brown, 2017, Philosophical Transactions of the Royal Society B: Biological Sciences
X-chromosome inactivation in Rett syndrome human induced pluripotent stem cells
Aaron Y.L. Cheung, Lindsay M. Horvath, Laura Carrel, James Ellis, 2012, Frontiers in Psychiatry
Deletion of an X-Inactivation Boundary Disrupts Adjacent Gene Silencing
Lindsay M. Horvath, Nan Li, Laura Carrel, 2013, PLoS Genetics
Computational and statistical analyses of insertional polymorphic endogenous retroviruses in a non-model organism
Le Bao, Daniel Elleder, Raunaq Malhotra, Michael DeGiorgio, Theodora Maravegias, Lindsay Horvath, Laura Carrel, Colin Gillin, Tomáš Hron, Helena Fábryová, David R. Hunter, Mary Poss, 2014, Computation on p. 221-245
Moderate X-chromosome inactivation skewing underlies factor VIII activity in symptomatic carriers from a family with mild haemophilia A
Peter Cygan, Laura Carrel, M. E. Eyster, 2016, Haemophilia on p. e559-e561
Investigation of discordant phenotype in mild Hemophilia A using whole exome sequencing
Peter H. Cygan, Sarah E. Arnold-Croop, Elizabeth A. Weidman, Fang Chen, Dajiang J. Liu, M. Elaine Eyster, Laura Carrel, 2020, Thrombosis Research on p. 36-39
Inferring genes that escape X-Chromosome inactivation reveals important contribution of variable escape genes to sex-biased diseases
Renan Sauteraud, Jill M. Stahl, Jesica James, Marisa Englebright, Fang Chen, Xiaowei Zhan, Laura Carrel, Dajiang J. Liu, 2021, Genome Research on p. 1629-1637
Prothrombotic variants as modifiers of clinical phenotype in four related individuals with haemophilia A
Laura Carrel, Sarah Arnold-Croop, Ty Achtermann, Fang Chen, Yuhuan Cheng, Dajiang Liu, M. Elaine Eyster, 2021, Haemophilia on p. e591-e595