Justin Brown
Associate Professor of Bioengineering

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229 Hallowell
University Park, PA - jlb92@psu.edu
- 814-865-5190
Research Summary
Understanding the fundamental mechanisms by which biomaterial interfaces alter the proliferation, migration and differentiation of mesenchymal stem cells, and application of these principles in the intelligent design of biomaterial scaffolds that facilitate generation or regeneration of musculoskeletal tissues
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Publication Tags
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Tissue Engineering Stem Cells Tissue Osteoblasts Bone Biocompatible Materials Nanofibers Tendons Titanium Scaffolds Bone And Bones Fiber Nanoparticles Mechanics Biomaterial Fibers Surface Cell Differentiation Orthopedics Nanofiber Gels Bioreactors Medical Nanotechnology Cell Movement Mesenchymal Stem CellsMost Recent Publications
Nanofiber curvature with Rho GTPase activity increases mouse embryonic fibroblast migration velocity
Daniel Bowers, Justin Brown, 2022, Integrative Biology on p. 295-308
Nanofiber curvature with Rho GTPase activity increases mouse embryonic fibroblast random migration velocity
Daniel T. Bowers, Justin L. Brown, 2021, Integrative Biology (United Kingdom) on p. 295-308
The Pull of Tissue Engineering: A STEM Outreach Program with a Modular Cyclic Stretch Device to Engage High Scholl
Tugba Ozdemir, Erdal Senocak, Gene Gerber, Secil Tayhan, Justin Brown, 2021, Biomedical Engineering Education on p. 9
3D-Printed Bioreactor Enhances Potential for Tendon Tissue Engineering
Brittany L. Banik, Justin L. Brown, 2020, Regenerative Engineering and Translational Medicine on p. 419-428
Bone Tissue Engineering
Justin Brown, Cato Laurencin, 2020, on p. 1373-1388
Bone Tissue Engineering
Justin L. Brown, Cato T. Laurencin, 2020, on p. 1373-1388
Controlling Stem Cell Fate via Highly Organized 2.5 Dimensional Bio-Instructive Fibrous Scaffolds
Merve Buluk, Jess Frith, Justin Brown, 2019, Proceedings of the 2019 Biomedical Engineering Society Annual Fall Meeting
Human mesenchymal stem cell morphology, migration, and differentiation on micro and nano-textured titanium
Emily G. Long, Merve Buluk, Michelle B. Gallagher, Jennifer M. Schneider, Justin L. Brown, 2019, Bioactive Materials on p. 249-255
Nanofibers as Bioinstructive Scaffolds Capable of Modulating Differentiation Through Mechanosensitive Pathways for Regenerative Engineering
Daniel T. Bowers, Justin L. Brown, 2019, Regenerative Engineering and Translational Medicine on p. 22-29
Identification of Key Signaling Pathways Orchestrating Substrate Topography Directed Osteogenic Differentiation Through High-Throughput siRNA Screening
Tugba Ozdemir, Daniel Bowers, Xiang Zhan, Debashis Ghosh, Justin L. Brown, 2019, Scientific Reports on p. 1-13
Most-Cited Papers
Polymeric nanoparticles: The future of nanomedicine
Brittany L. Banik, Pouria Fattahi, Justin L. Brown, 2016, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology on p. 271-299
Synthesis and characterization of biomimetic citrate-based biodegradable composites
Richard T. Tran, Liang Wang, Chang Zhang, Minjun Huang, Wanjin Tang, Chi Zhang, Zhongmin Zhang, Dadi Jin, Brittany Banik, Justin L. Brown, Zhiwei Xie, Xiaochun Bai, Jian Yang, 2014, Journal of Biomedical Materials Research - Part A on p. 2521-2532
3D Near-Field Electrospinning of Biomaterial Microfibers with Potential for Blended Microfiber-Cell-Loaded Gel Composite Structures
Pouria Fattahi, Jordan T. Dover, Justin L. Brown, 2017, Advanced healthcare materials
Substrate curvature sensing through Myosin IIa upregulates early osteogenesis
Tugba Ozdemir, LICHONG XU, Christopher Siedlecki, Justin L. Brown, 2013, Integrative Biology (United Kingdom) on p. 1407--1416
Human mesenchymal stem cell morphology, migration, and differentiation on micro and nano-textured titanium
Emily G. Long, Merve Buluk, Michelle B. Gallagher, Jennifer M. Schneider, Justin L. Brown, 2019, Bioactive Materials on p. 249-255
Osteoinductive biomaterial geometries for bone regenerative engineering
Tugba Ozdemir, Andrew M. Higgins, Justin L. Brown, 2013, Current Pharmaceutical Design on p. 3446-3455
The role of substrate topography on the cellular uptake of nanoparticles
C Huang, T Ozdemir, Li Chong Xu, Peter J. Butler, Christopher A. Siedlecki, Justin L. Brown, Sulin Zhang, 2015, Journal of Biomedical Materials Research - Part B Applied Biomaterials on p. 488-495
Polymeric Biomaterials in Nanomedicine
Brittany L. Banik, Justin L. Brown, 2014, on p. 387-395
Geometry sensing through POR1 regulates Rac1 activity controlling early osteoblast differentiation in response to nanofiber diameter
A. M. Higgins, B. L. Banik, J. L. Brown, 2015, Integrative Biology (United Kingdom) on p. 229-236
Multiscale Poly-(ϵ-caprolactone) Scaffold Mimicking Non-linearity in Tendon Tissue Mechanics
Brittany L. Banik, Gregory S. Lewis, Justin L. Brown, 2016, Regenerative Engineering and Translational Medicine