Justin Brown

Associate Professor of Bioengineering

Justin Brown

Research Summary

Understanding the fundamental mechanisms by which biomaterial interfaces alter the proliferation, migration and differentiation of mesenchymal stem cells, and application of these principles in the intelligent design of biomaterial scaffolds that facilitate generation or regeneration of musculoskeletal tissues

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Osteoblasts Nanofibers Tissue Engineering Stem Cells Bone Fibers Titanium Biocompatible Materials Fiber Nanoparticles Tissue Bone And Bones Scaffolds Biomaterial Nanofiber Surface Substrates Cell Differentiation Orthopedics Tendons Bioreactors Medical Nanotechnology Gels Cell Movement Topography

Most Recent Papers

Nanofiber curvature with Rho GTPase activity increases mouse embryonic fibroblast migration velocity

Daniel Bowers, Justin Brown, 2022, Integrative Biology on p. 295-308

Nanofiber curvature with Rho GTPase activity increases mouse embryonic fibroblast random migration velocity

Daniel T. Bowers, Justin L. Brown, 2021, Integrative Biology (United Kingdom) on p. 295-308

The Pull of Tissue Engineering: A STEM Outreach Program with a Modular Cyclic Stretch Device to Engage High Scholl

Tugba Ozdemir, Erdal Senocak, Gene Gerber, Secil Tayhan, Justin Brown, 2021, Biomedical Engineering Education on p. 9

3D-Printed Bioreactor Enhances Potential for Tendon Tissue Engineering

Brittany L. Banik, Justin L. Brown, 2020, Regenerative Engineering and Translational Medicine on p. 419-428

Bone Tissue Engineering

Justin Brown, Cato Laurencin, 2020, on p. 1373-1388

Identification of Key Signaling Pathways Orchestrating Substrate Topography Directed Osteogenic Differentiation Through High-Throughput siRNA Screening

Tugba Ozdemir, Daniel T. Bowers, Xiang Zhan, Debashis Ghosh, Justin L. Brown, 2019, Scientific Reports

Human mesenchymal stem cell morphology, migration, and differentiation on micro and nano-textured titanium

Emily G. Long, Merve Buluk, Michelle B. Gallagher, Jennifer M. Schneider, Justin L. Brown, 2019, Bioactive Materials on p. 249-255

Nanofibers as Bioinstructive Scaffolds Capable of Modulating Differentiation Through Mechanosensitive Pathways for Regenerative Engineering

Daniel T. Bowers, Justin L. Brown, 2019, Regenerative Engineering and Translational Medicine on p. 22-29

In Vitro Response to Implants with Internally Roughened Micron and Nano Features

Brittany Banik, Jennifer Schneider, Michelle Gallagher, Justin Brown, 2019, ORS 2019 Annual Meeting ePosters

Nanofibers as Bioinstructive Scaffolds Capable of Modulating Differentiation Through Mechanosensitive Pathways for Regenerative Engineering

2018, Regenerative Engineering and Translational Medicine on p. 1-8

Most-Cited Papers

Polymeric nanoparticles

Brittany L. Banik, Pouria Fattahi, Justin L. Brown, 2016, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology on p. 271-299

Synthesis and characterization of biomimetic citrate-based biodegradable composites

Richard T. Tran, Liang Wang, Chang Zhang, Minjun Huang, Wanjin Tang, Chi Zhang, Zhongmin Zhang, Dadi Jin, Brittany Banik, Justin L. Brown, Zhiwei Xie, Xiaochun Bai, Jian Yang, 2014, Journal of Biomedical Materials Research - Part A on p. 2521-2532

Substrate curvature sensing through Myosin IIa upregulates early osteogenesis

Tugba Ozdemir, Li Chong Xu, Christopher Siedlecki, Justin L. Brown, 2013, Integrative Biology (United Kingdom) on p. 1407-1416

3D Near-Field Electrospinning of Biomaterial Microfibers with Potential for Blended Microfiber-Cell-Loaded Gel Composite Structures

Pouria Fattahi, Jordan T. Dover, Justin L. Brown, 2017, Advanced healthcare materials

Osteoinductive biomaterial geometries for bone regenerative engineering

Tugba Ozdemir, Andrew M. Higgins, Justin L. Brown, 2013, Current Pharmaceutical Design on p. 3446-3455

Human mesenchymal stem cell morphology, migration, and differentiation on micro and nano-textured titanium

Emily G. Long, Merve Buluk, Michelle B. Gallagher, Jennifer M. Schneider, Justin L. Brown, 2019, Bioactive Materials on p. 249-255

The role of substrate topography on the cellular uptake of nanoparticles

Changjin Huang, Tugba Ozdemir, Li Chong Xu, Peter J. Butler, Christopher A. Siedlecki, Justin L. Brown, Sulin Zhang, 2016, Journal of Biomedical Materials Research - Part B Applied Biomaterials on p. 488-495

Nanofiber diameter-dependent MAPK activity in osteoblasts

Devina Jaiswal, Justin L. Brown, 2012, Journal of Biomedical Materials Research - Part A on p. 2921-2928

Geometry sensing through POR1 regulates Rac1 activity controlling early osteoblast differentiation in response to nanofiber diameter

A. M. Higgins, B. L. Banik, J. L. Brown, 2015, Integrative Biology (United Kingdom) on p. 229-236

Polymeric Biomaterials in Nanomedicine

Brittany L. Banik, Justin L. Brown, 2014, on p. 387-395