Justin Brown

Associate Professor of Bioengineering

Justin Brown

Research Summary

Understanding the fundamental mechanisms by which biomaterial interfaces alter the proliferation, migration and differentiation of mesenchymal stem cells, and application of these principles in the intelligent design of biomaterial scaffolds that facilitate generation or regeneration of musculoskeletal tissues

Huck Graduate Students

Huck Affiliations

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Publication Tags

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Biocompatible Materials Tendons Nanoparticles Tissue Engineering Osteoblasts Mechanics Tissue Fiber Biomaterial Bone Stem Cells Fibers Bone And Bones Scaffolds Bioreactors Titanium Medical Nanotechnology Gels Nanofibers Surface Biomimetics Substrates Alkaline Phosphatase Drug Delivery Microfibers

Most Recent Publications

Characterization of the mechanical state of human mesenchymal stem cells on micro- or nano-textured Ti6Al4V surfaces

Elizabeth Byers, Michelle Gallagher, James Sugar, Justin Brown, 2023, Canadian Journal of Surgery on p. S50

Canadian Spine Society: 23rd Annual Scientific Conference, Wednesday, March 1 - Saturday, March 4, Fairmont Le Château Frontenac, Québec, Que., Canada

Manjot Birk, Kara Sidhu, Marina Rosa Filezio, Vishwajeet Singh, Fabio Ferri-de-Barros, Vivien Chan, Geoffrey Shumilak, Andrew Nataraj, Holly Langston, Nicholas J. Yee, Carlo Iorio, Nicholas Shkumat, Brett Rocos, Birgit Ertl-Wagner, David Lebel, Mark W. Camp, Evan Dimentberg, Neil Saran, Melissa Laflamme, Jean A. Ouellet, Jessica Wenghofer, Holly Livock, Luke Beaton, Andrew Tice, Kevin Smit, Ryan Graham, Matias Pereira Duarte, Marjolaine Roy-Beaudry, Isabelle Turgeon, Julie Joncas, Jean Marc Mac-Thiong, Hubert Labelle, Soraya Barchi, Stefan Parent, Tara Gholamian, Holly Livock, Andrew Tice, Kevin Smit, Samuel Yoon, Amna Zulfiqar, Anne Murphy, Natasha Bath, Stanley Moll, David Lebel, Mark W. Camp, Brett Rocos, David Eduard Lebel, Reinhard Zeller, Jennifer A. Dermott, Dorothy J. Kim, Alison Anthony, Reinhard Zeller, David E. Lebel, Zhi Wang, Jesse Shen, Youssef Kamel, Jia Liu, Daniel Shedid, Fidaa Al-Shakfa, Sung Joo Yuh, Ghassan Boubez, Maroun Rizkallah, Frederic Lavoie, Zhi Wang, Fatemeh Alavi, Christopher Nielsen, Raja Rampersaud, Stephen Lewis, Angela M. Cheung, Chloe Cadieux, Renan Fernandes, Pawel Brzozowski, Radovan Zdero, Chris Bailey, Parham Rasoulinejad, Ahmed Cherry, Ragavan Manoharan, Mark Xu, Nisaharan Srikandarajah, Carlo Iorio, Aditya Raj, Kristen Beange, Ryan Graham, Holly Livock, Kevin Smit, Christopher J. Nielsen, Y. Raja Rampersaud, Stephen J. Lewis, Ali Asghar Mohammadi Nasrabadi, Gemah Moammer, John Mc Phee, Taryn Walker, Jennifer C. Urquhart, R. Andrew Glennie, Y. Raja Rampersaud, Charles G. Fisher, Chris S. Bailey, Brandon J. Herrington, Renan R. Fernandes, Jennifer C. Urquhart, Parham Rasoulinejad, Fawaz Siddiqi, Christopher S. Bailey, Jennifer Urquhart, R. Andrew Glennie, Chris S. Bailey, Michael M.H. Yang, Jay Riva-Cambrin, Jonathan Cunningham, Steven Casha, Chloe N. Cadieux, Jennifer Urquhart, Renan Fernandes, Andrew Glennie, Charles Fisher, Raja Rampersaud, Stephen Lewis, Ahmed Cherry, Aditya Raj, Greg McIntosh, Ragavan Manoharan, Jean Christophe Murray, Christopher Nielsen, Mark Xu, Nisaharan Srikandarajah, Carlo Iorio, Anthony Perruccio, Mayilee Canizares, Raja Rampersaud, Dana El-Mughayyar, Erin Bigney, Eden Richardson, Neil Manson, Edward Abraham, Najmedden Attabib, Chris Small, George Kolyvas, Andre LeRoux, Canadian Spine Outcomes, Research Network Investigators, Jeff Hebert, Victor Baisamy, Maroun Rizkallah, Jesse Shen, Thierry Cresson, Carlos Vazquez, Zhi Wang, Ghassan Boubez, Tiffany Lung, Mayilee Canizares, Anthony Perruccio, Raja Rampersaud, Eric J. Crawford, Robert A. Ravinsky, Anthony V. Perruccio, Y. Raja Rampersaud, Peter C. Coyte, Michael Bond, John Street, Charles Fisher, Raphaele Charest-Morin, Jason M. Sutherland, Arthur R. Bartolozzi, Ori Barzilai, Dean Chou, Ilya Laufer, Jorrit Jan Verlaan, Arjun Sahgal, Laurence D. Rhines, Daniel M. Scuibba, Aron Lazary, Michael H. Weber, James M. Schuster, Stefano Boriani, Chetan Bettegowda, Paul M. Arnold, Michelle J. Clarke, Michael G. Fehlings, Jeremy J. Reynolds, Ziya L. Gokaslan, Charles G. Fisher, Nicolas Dea, Anne L. Versteeg, Raphaele Charest-Morin, Ilya Laufer, William Teixeira, Ori Barzilai, Alessandro Gasbarrini, Michael G. Fehlings, Dean Chou, Michael G. Johnson, Ziya L. Gokaslan, Nicolas Dea, Jorrit Jan Verlaan, Tony Goldschlager, John H. Shin, John E. O'Toole, Daniel M. Sciubba, Chetan Bettegowda, Michelle J. Clarke, Michael H. Weber, Addisu Mesfin, Norio Kawahara, Rory Goodwin, Alexander Disch, Aron Lazary, Stefano Boriani, Arjun Sahgal, Laurence Rhines, Charles G. Fisher, Anne L. Versteeg, Roxanne Gal, Leilani Reich, Angela Tsang, Arjun Sahgal, Jorrit Jan Verlaan, Charles G. Fisher, Lenny Verkooijen, Céline Belguendouz, Rayan AlKafi, Mark A. MacLean, Miltiadis Georgiopoulos, Raphaele Charest-Morin, Niccole Germscheid, C. Rory Goodwin, Michael Weber, Ao Spine International, Hao Zhang, Pamela Brindamour, Danielle Boule, Marcia Rebecca Correale, Leslie Jayne Soever, Raja Rampersaud, Claudia Cristina Malic, Melanie Dubreuil, Kate Duke, Stephen P. Kingwell, Zihan Lin, Mark A. MacLean, Lisa C. Julien, Glenn Patriquin, Jason LeBlanc, Ryan Green, Jacob Alant, Sean Barry, R. Andrew Glennie, William Oxney, Sean D. Christie, Mohamed Sarraj, Abdullah Alqahtani, Patrick Thornley, Frank Koziarz, Christopher S. Bailey, Millaray Freire-Archer, Kunal Bhanot, Edward Kachur, Mohit Bhandari, Colby Oitment, Armaan K. Malhotra, Michael Balas, Blessing N.R. Jaja, Erin M. Harrington, Johann Hofereiter, Rachael H. Jaffe, Yingshi He, James P. Byrne, Jefferson R. Wilson, Christopher D. Witiw, Kennedy C.M. Brittain, Sean Christie, Saranyan Pillai, Marcel F. Dvorak, Nathan Evaniew, Melody Chen, Zeina Waheed, Naama Rotem-Kohavi, Nader Fallah, Vanessa K. Noonan, Charles G. Fisher, Raphaële Charest-Morin, Nicolas Dea, Tamir Ailon, John Street, Brian K. Kwon, Ryan V. Sandarage, Ahmad Galuta, Diana Ghinda, Jason C.S. Kwan, Eve C. TsaI, Laureen D. Hachem, James Hong, Alexander Velumian, Andrea J. Mothe, Charles H. Tator, Michael G. Fehlings, Husain Shakil, Blessing N.R. Jaja, Peng Zhang, Rachael Jaffe, Armaan K. Malhotra, Jefferson R. Wilson, Christopher D. Witiw, Marcel F. Dvorak, Melody Chen, Zeina Waheed, Jijie Xu, Nader Fallah, Vanessa Noonan, Brian Kwon, Charlotte Dandurand, Sander Muijs, Marcel Dvorak, Klaus Schnake, Cumhur, Ner Ouml Ner, Ryan Greene, Bradley Furlong, Jenna Smith-Forrester, Michelle Swab, Sean D. Christie, Amanda Hall, Erika Leck, Marcel F. Dvorak, F. Cumhur, Ner Ouml Ner, Alexander R. Vaccaro, Lorin M. Benneker, Shanmuganathan Rajasekaran, Mohammad El-Sharkawi, Eugen Cezar Popescu, Jin Wee Tee, Jerome Paquet, John C. France, Richard Allen, William F. Lavelle, Miguel Hirschfeld, Ner Ouml Ner, Renan Rodrigues Fernandes, Patrick Thornley, Jennifer Urquhart, Sean Kelly, Nasser Alenezi, Abdulmajeed Alahmari, Fawaz Siddiqi, Supriya Singh, Parham Rasoulinejad, Christopher Bailey, Nathan Evaniew, Nicolas Dea, Greg McIntosh, Bradley Jacobs, Loïc St-Laurent-Lebeux, Étienne Bourassa-Moreau, Mohamed Sarraj, Meerab Majeed, Daipayan Guha, Markian Pahuta, Greg McIntosh, Alex B. Bak, Mohammed A. Alvi, Ali Moghaddamjou, Michael G. Fehlings, Yan Gabriel Morais David Silva, Greg McIntosh, Sonia Bedard, Newton Pimenta, Jocelyn Blanchard, Jerome Couture, Bernard LaRue, Csorn Investigators, Tyler Adams, Erin Cunningham, Dana El-Mughayyar, Erin Bigney, Amanda Vandewint, Niel Manson, Edward Abraham, Chris Small, Najmedden Attabib, Eden Richardson, Michael Bond, Troy Hillier, Chris S. Bailey, Charles Fisher, Raja Rampersaud, Prosper Koto, R. Andrew Glennie, Alex Soroceanu, Fred Nicholls, Ken Thomas, Nathan Evaniew, Peter Lewkonia, Jacques Bouchard, Brad Jacobs, David Ben-Israel, Charles Fisher, Nicolas Dea, Raja Rampersaud, Kenneth C. Thomas, Jean Christophe Murray, Christopher Nielsen, Ragavan Manoharan, Ahmed Cherry, Aditiya Raj, Mark Xu, Carlo Iorio, Chris Bailey, Nicolas Dea, Charles Fisher, Hamilton Hall, Neil Manson, Kenneth Thomas, Mayilee Canizares, R. Andrew Glennie, Chris Bailey, Rena Far, Jay Riva-Cambrin, Yan Silva, Newton Godoy Pimenta, Bernard LaRue, Sonia Bedard, Sonia Cheng Oviedo, Julien Goulet, Jerome Couture, Jocelyn Blanchard, James McDonald, Fares Al-Jahdali, Jennifer Urquhart, Abdulmajeed Alahmari, Raja Rampersaud, Charles Fisher, Chris Bailey, Nathan Evaniew, Y. Raja Rampersaud, Christopher S. Bailey, W. Bradley Jacobs, David W. Cadotte, Kenneth C. Thomas, Najmedden Attabib, Jérôme Paquet, Sean D. Christie, Michael H. Weber, Philippe Phan, Raphaële Charest-Morin, Charles G. Fisher, Hamilton Hall, Nicolas Dea, Armaan K. Malhotra, Aileen M. Davis, Yingshi He, Erin M. Harrington, Blessing N.R. Jaja, Mary P. Zhu, Husain Shakil, Nicolas Dea, W. Bradley Jacobs, David W. Cadotte, Jérôme Paquet, Michael H. Weber, Sean D. Christie, Andrew Nataraj, Christopher S. Bailey, Michael G. Johnson, Charles G. Fisher, Neil Manson, Y. Raja Rampersaud, Hamilton Hall, Michael G. Fehlings, Henry Ahn, Howard J. Ginsberg, Christopher D. Witiw, Jefferson R. Wilson, Greg McIntosh, Raphaële Charest-Morin, Michael A. Rizzuto, Tamir Ailon, Nicolas Dea, Nathan Evaniew, Bradley W. Jacobs, Jerome Paquet, Hamilton Hall, Christopher S. Bailey, Michael Weber, Andrew Nataraj, Najmedden Attabib, David W. Cadotte, Neil Manson, Sean D. Christie, Kenneth C. Thomas, Jefferson R. Wilson, Charles G. Fisher, Raphaele Charest-Morin, Jacques Bouchard, Charlotte Dandurand, Pedram Farimani Laghaei, Tamir Ailon, Raphaele Charest-Morin, Nicolas Dea, Marcel Dvorak, Charles Fisher, Brian K. Kwon, Scott Paquette, John Street, Vishal P. Varshney, Ramesh Sahjpaul, Scott Paquette, Jill Osborn, Lior M. Elkaim, Oliver J. Lasry, Aditya Raj, Jean Christophe Murray, Greg McIntosh, Christopher Nielsen, Nisaharan Srikandarajah, Ragavan Manoharan, Carlo Iorio, Mark Xu, Anthony Perruccio, Mayilee Canizares, Yoga Raja Rampersaud, Alexandra Stratton, Sarah Tierney, Eugene K. Wai, Philippe Phan, Stephen Kingwell, Marie Claude Magnan, Barend Spanninga, Thomáy Claire A. Hoelen, Scott Johnson, Chris S. Bailey, R. Andrew Glennie, Jordan J. Levett, Lior M. Elkaim, Naif M. Alotaibi, Michael H. Weber, Nicolas Dea, Ahmed Cherry, Albert Yee, Nadia Jaber, Michael Fehlings, Edward Abraham, Chris Small, Najmedden Attabib, Eden Richardson, Joel Werier, Kevin Smit, James Villeneuve, Adam Sachs, Hesham Abdelbary, Yusra Kassim Al-Mosuli, Kawan Rakhra, Philippe Phan, Kosei Nagata, Jeffrey L. Gum, Morgan E. Brown, Christy L. Daniels, Leah Y. Carreon, John Peter Bonello, Robert Koucheki, Aazad Abbas, Johnathan Lex, Nicholas Nucci, Cari Whyne, Jeremie Larouche, Henry Ahn, Joel Finkelstein, Stephen Lewis, Jay Toor, Nathan J. Lee, Lindsay D. Orosz, Jeffrey L. Gum, Gregory T. Poulter, Ehsan Jazini, Colin M. Haines, Christopher R. Good, Eric J. Crawford, Millaray Freire-Archer, Mohamed Sarraj, Fawaz AlShaalan, Alex Koziarz, Patrick Thornley, Haitham Alnemari, Colby Oitment, Lalita Bharadwaj, Dana El-Mughayyar, Erin Bigney, Neil Manson, Eden Richardson, Jill Kearney, Csorn Investigators, Jordan J. Levett, Farbod Niazi, Rakan Bokhari, Naif M. Alotaibi, Oliver J. Lasry, Vincent Bissonnette, David Yen, Varun S. Muddaluru, Pranjan Gandhi, Alexander Mastrolonardo, Daipayan Guha, Markian A. Pahuta, Trevor Vandertuin, Gillian Ritcey, Daniel Rainham, Mamdoh Alhawsawi, Rohail Mumtaz, Mark Abdelnour, Feras Qumquji, Alex Soroceanu, Ganesh Swamy, Kenneth Thomas, Eugene Wai, Philippe Phan, Lindsay D. Orosz, Tarek Yamout, Thomas C. Schuler, Tiffany Nguyen, Marcelo Oppermann, Shaurya Gupta, Joel Ramjist, Priscila Santos Oppermann, Jordan J. Levett, Christian Ioro-Morin, Marco Bonizzato, Marcelo Oppermann, Priscila S. Oppermann, Youngkyung Jung, Pranjan Gandhi, Daipayan Guha, Robert Koucheki, John Peter Bonello, Aazad Abbas, Johnathan R. Lex, Cari Whyne, Albert Yee, Henry Ahn, Joel Finkelstein, Jeremie Larouche, Stephen Lewis, Jay Toor, Alaina Dhawan, Jillian Dhawan, Ajay N. Sharma, Daniel B. Azzam, Ahmed Cherry, Nathan J. Lee, Barzany B. Ridha, Amit Persad, Daryl Fourney, Elizabeth Byers, Michelle Gallagher, James Sugar, Justin L. Brown, Manmohan Singh, Pankaj Kumar Singh, Peyton Lloyd Lawrence, Shevaughn Dell, Ronette Goodluck-Tyndall, Kevin Wade, Mark Morgan, Carl Bruce, Yan Gabriel Morais David Silva, Newton Pimenta, Bernard LaRue, Salman Aldakhil, Jocelyn Blanchard, Jerome Couture, Julien Goulet, Drew A. Bednar, Ruheksh Raj, Chris Bailey, Ryan Greene, Jennyfer Paulla Galdino Chaves, Mohammed Zarrabian, Leif Sigurdson, Yoga Raja Rampersaud, 2023, Canadian Journal of Surgery on p. S1-S53

Endothelial Cell Selectivity to Nanoparticles Depends on Mechanical Phenotype

Pouria Fattahi, Yin Ting Yeh, Tiankai Zhao, Mousa Younesi, Changjin Huang, Mauricio Terrones, Siyang Zheng, Justin L. Brown, Dan Dongeun Huh, Sulin Zhang, Peter J. Butler, 2023, Advanced Materials Interfaces

Evaluation of focal adhesion mediated subcellular curvature sensing in response to engineered extracellular matrix

Daniel T. Bowers, Mary Elizabeth McCulloch, Justin L. Brown, 2023, Biointerphases

Spatial and depth mapping of nascent mineralization on Ti6Al4V surfaces demonstrating hierarchical macro- micro- nanoscale surface features

Vraj Shah, Michelle Gallagher, Aaron Cheung, Justin Brown, 2022, Canadian Journal of Surgery on p. S130-S131

Nanofiber curvature with Rho GTPase activity increases mouse embryonic fibroblast migration velocity

Daniel Bowers, Justin Brown, 2022, Integrative Biology on p. 295-308

The Pull of Tissue Engineering: A STEM Outreach Program with a Modular Cyclic Stretch Device to Engage High Scholl

Tugba Ozdemir, Erdal Senocak, Gene Gerber, Secil Tayhan, Justin Brown, 2022, Biomedical Engineering Education on p. 9

Nanofiber curvature with Rho GTPase activity increases mouse embryonic fibroblast random migration velocity

Daniel T. Bowers, Justin L. Brown, 2021, Integrative Biology (United Kingdom) on p. 295-308

3D-Printed Bioreactor Enhances Potential for Tendon Tissue Engineering

Brittany L. Banik, Justin L. Brown, 2020, Regenerative Engineering and Translational Medicine on p. 419-428

Bone Tissue Engineering

Justin Brown, Cato Laurencin, 2020, on p. 1373-1388

Most-Cited Papers

Polymeric nanoparticles: The future of nanomedicine

Brittany L. Banik, Pouria Fattahi, Justin L. Brown, 2016, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology on p. 271-299

Human mesenchymal stem cell morphology, migration, and differentiation on micro and nano-textured titanium

Emily G. Long, Merve Buluk, Michelle B. Gallagher, Jennifer M. Schneider, Justin L. Brown, 2019, Bioactive Materials on p. 249-255

Synthesis and characterization of biomimetic citrate-based biodegradable composites

Richard T. Tran, Liang Wang, Chang Zhang, Minjun Huang, Wanjin Tang, Chi Zhang, Zhongmin Zhang, Dadi Jin, Brittany Banik, Justin L. Brown, Zhiwei Xie, Xiaochun Bai, Jian Yang, 2014, Journal of Biomedical Materials Research - Part A on p. 2521-2532

3D Near-Field Electrospinning of Biomaterial Microfibers with Potential for Blended Microfiber-Cell-Loaded Gel Composite Structures

Pouria Fattahi, Jordan T. Dover, Justin L. Brown, 2017, Advanced healthcare materials

Substrate curvature sensing through Myosin IIa upregulates early osteogenesis

Tugba Ozdemir, LICHONG XU, Christopher Siedlecki, Justin L. Brown, 2013, Integrative Biology (United Kingdom) on p. 1407--1416

Osteoinductive biomaterial geometries for bone regenerative engineering

Tugba Ozdemir, Andrew M. Higgins, Justin L. Brown, 2013, Current Pharmaceutical Design on p. 3446-3455

The role of substrate topography on the cellular uptake of nanoparticles

C Huang, T Ozdemir, Li Chong Xu, Peter J. Butler, Christopher A. Siedlecki, Justin L. Brown, Sulin Zhang, 2015, Journal of Biomedical Materials Research - Part B Applied Biomaterials on p. 488-495

Polymeric Biomaterials in Nanomedicine

Brittany L. Banik, Justin L. Brown, 2014, on p. 387-395

Geometry sensing through POR1 regulates Rac1 activity controlling early osteoblast differentiation in response to nanofiber diameter

A. M. Higgins, B. L. Banik, J. L. Brown, 2015, Integrative Biology (United Kingdom) on p. 229-236

Multiscale Poly-(ϵ-caprolactone) Scaffold Mimicking Non-linearity in Tendon Tissue Mechanics

Brittany L. Banik, Gregory S. Lewis, Justin L. Brown, 2016, Regenerative Engineering and Translational Medicine