Justin Brown

Associate Professor of Bioengineering

Justin Brown

Research Summary

Understanding the fundamental mechanisms by which biomaterial interfaces alter the proliferation, migration and differentiation of mesenchymal stem cells, and application of these principles in the intelligent design of biomaterial scaffolds that facilitate generation or regeneration of musculoskeletal tissues

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Tissue Engineering Stem Cells Tissue Osteoblasts Bone Biocompatible Materials Tendons Titanium Nanofibers Scaffolds Bone And Bones Fiber Nanoparticles Mechanics Biomaterial Fibers Surface Cell Differentiation Orthopedics Nanofiber Gels Bioreactors Cell Movement Medical Nanotechnology Mesenchymal Stem Cells

Most Recent Publications

Nanofiber curvature with Rho GTPase activity increases mouse embryonic fibroblast migration velocity

Daniel Bowers, Justin Brown, 2022, Integrative Biology on p. 295-308

Nanofiber curvature with Rho GTPase activity increases mouse embryonic fibroblast random migration velocity

Daniel T. Bowers, Justin L. Brown, 2021, Integrative Biology (United Kingdom) on p. 295-308

The Pull of Tissue Engineering: A STEM Outreach Program with a Modular Cyclic Stretch Device to Engage High Scholl

Tugba Ozdemir, Erdal Senocak, Gene Gerber, Secil Tayhan, Justin Brown, 2021, Biomedical Engineering Education on p. 9

3D-Printed Bioreactor Enhances Potential for Tendon Tissue Engineering

Brittany L. Banik, Justin L. Brown, 2020, Regenerative Engineering and Translational Medicine on p. 419-428

Bone Tissue Engineering

Justin Brown, Cato Laurencin, 2020, on p. 1373-1388

Bone Tissue Engineering

Justin L. Brown, Cato T. Laurencin, 2020, on p. 1373-1388

Controlling Stem Cell Fate via Highly Organized 2.5 Dimensional Bio-Instructive Fibrous Scaffolds

Merve Buluk, Jess Frith, Justin Brown, 2019, Proceedings of the 2019 Biomedical Engineering Society Annual Fall Meeting

Human mesenchymal stem cell morphology, migration, and differentiation on micro and nano-textured titanium

Emily G. Long, Merve Buluk, Michelle B. Gallagher, Jennifer M. Schneider, Justin L. Brown, 2019, Bioactive Materials on p. 249-255

Nanofibers as Bioinstructive Scaffolds Capable of Modulating Differentiation Through Mechanosensitive Pathways for Regenerative Engineering

Daniel T. Bowers, Justin L. Brown, 2019, Regenerative Engineering and Translational Medicine on p. 22-29

Identification of Key Signaling Pathways Orchestrating Substrate Topography Directed Osteogenic Differentiation Through High-Throughput siRNA Screening

Tugba Ozdemir, Daniel Bowers, Xiang Zhan, Debashis Ghosh, Justin L. Brown, 2019, Scientific Reports on p. 1-13

Most-Cited Papers

Polymeric nanoparticles: The future of nanomedicine

Brittany L. Banik, Pouria Fattahi, Justin L. Brown, 2016, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology on p. 271-299

Synthesis and characterization of biomimetic citrate-based biodegradable composites

Richard T. Tran, Liang Wang, Chang Zhang, Minjun Huang, Wanjin Tang, Chi Zhang, Zhongmin Zhang, Dadi Jin, Brittany Banik, Justin L. Brown, Zhiwei Xie, Xiaochun Bai, Jian Yang, 2014, Journal of Biomedical Materials Research - Part A on p. 2521-2532

3D Near-Field Electrospinning of Biomaterial Microfibers with Potential for Blended Microfiber-Cell-Loaded Gel Composite Structures

Pouria Fattahi, Jordan T. Dover, Justin L. Brown, 2017, Advanced healthcare materials

Substrate curvature sensing through Myosin IIa upregulates early osteogenesis

Tugba Ozdemir, LICHONG XU, Christopher Siedlecki, Justin L. Brown, 2013, Integrative Biology (United Kingdom) on p. 1407--1416

Human mesenchymal stem cell morphology, migration, and differentiation on micro and nano-textured titanium

Emily G. Long, Merve Buluk, Michelle B. Gallagher, Jennifer M. Schneider, Justin L. Brown, 2019, Bioactive Materials on p. 249-255

Osteoinductive biomaterial geometries for bone regenerative engineering

Tugba Ozdemir, Andrew M. Higgins, Justin L. Brown, 2013, Current Pharmaceutical Design on p. 3446-3455

The role of substrate topography on the cellular uptake of nanoparticles

C Huang, T Ozdemir, Li Chong Xu, Peter J. Butler, Christopher A. Siedlecki, Justin L. Brown, Sulin Zhang, 2015, Journal of Biomedical Materials Research - Part B Applied Biomaterials on p. 488-495

Polymeric Biomaterials in Nanomedicine

Brittany L. Banik, Justin L. Brown, 2014, on p. 387-395

Geometry sensing through POR1 regulates Rac1 activity controlling early osteoblast differentiation in response to nanofiber diameter

A. M. Higgins, B. L. Banik, J. L. Brown, 2015, Integrative Biology (United Kingdom) on p. 229-236

Multiscale Poly-(ϵ-caprolactone) Scaffold Mimicking Non-linearity in Tendon Tissue Mechanics

Brittany L. Banik, Gregory S. Lewis, Justin L. Brown, 2016, Regenerative Engineering and Translational Medicine