Joseph Wang

Assistant Professor of Cell and Biological Systems

Joseph Wang

Research Summary

The molecular mechanisms underlying the complex life cycle of Hepatitis B virus (HBV) infection using electron microscopy (primary) and other biochemical and biophysical approaches.

Huck Affiliations

Links

Most Recent Publications

Bilayer or Not: Revisiting the Structural Nature of HBV Subviral Particles

Haitao Liu, Sonal Garg, Jianming Hu, Joseph Che Yen Wang, 2025, Journal of Medical Virology

Genetically Engineered, Multichromophore Virus-Like Nanoparticles with Ultranarrow Distribution of Emission Intensity

Irina B. Tsvetkova, Nora Roos, Lohra M. Miller, Nadia DiNunno, Marcel Conrady, Domenic Ebert, Hauke Lilie, Liam W. Scott, Martin F. Jarrold, Joseph Che Yen Wang, Claudia Simon, Bogdan Dragnea, 2025, ACS Nano on p. 479-487

Unveiling the Molecular Architecture of HBV Spherical Subviral Particles: Structure, Symmetry, and Lipid Dynamics

Sonal Garg, Alyssa Ochetto, Jianming Hu, Joseph Che Yen Wang, 2025, Viruses

A narrow ratio of nucleic acid to SARS-CoV-2 N-protein enables phase separation

Patrick M. Laughlin, Kimberly Young, Giovanni Gonzalez-Gutierrez, Joseph C.Y. Wang, Adam Zlotnick, 2024, Journal of Biological Chemistry

Charge Detection Mass Spectrometry Reveals Favored Structures in the Assembly of Virus-Like Particles: Polymorphism in Norovirus GI.1

Lohra M. Miller, Benjamin E. Draper, Joseph C.Y. Wang, Martin F. Jarrold, 2024, Analytical Chemistry on p. 13150-13157

The CD4 T cell-independent IgG response during persistent virus infection favors emergence of neutralization-escape variants

Katelyn Ayers, Matthew Lauver, Kalynn Alexander, Ge Jin, Kitt Paraiso, Alyssa Ochetto, Sonal Garg, Daniel Goetschius, S Hafenstein, Joseph Wang, others, 2024, bioRxiv on p. 2024--12

Structure of the Hepatitis B virus capsid quasi-6-fold with a trapped C-terminal domain reveals capsid movements associated with domain exit

Christine Kim, Christopher J. Schlicksup, Carolina Pérez-Segura, Jodi A. Hadden-Perilla, Joseph Che Yen Wang, Adam Zlotnick, 2023, Journal of Biological Chemistry

Protein Structure Predictions, Atomic Model Building, and Validation Using a Cryo-EM Density Map from Hepatitis B Virus Spherical Subviral Particle

Nadia DiNunno, Emily N. Bianchini, Haitao Liu, Joseph Che Yen Wang, 2023, Bio-protocol

Characterization of Intracellular Precore-Derived Proteins and Their Functions in Hepatitis B Virus-Infected Human Hepatocytes

Xupeng Hong, Emily N. Bianchini, Joseph Che Yen Wang, Jianming Hu, 2023, mBio

Cryo-EM structure and molecular dynamic simulations explain the enhanced stability and ATP activity of the pathological chaperonin mutant

Aiza Syed, Jihang Zhai, Baolin Guo, Yuan Zhao, Joseph Wang, Lingling Chen, 2023, Structure with Folding & design on p. 575-584.e3

Most-Cited Papers

Retraction of DNA-bound type IV competence pili initiates DNA uptake during natural transformation in Vibrio cholerae

Courtney Ellison, Triana Dalia, Alfredo Vidal Ceballos, Joseph Wang, Nicolas Biais, Yves Brun, Ankur Dalia, 2018, Nature Microbiology on p. 773-780

Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids

Christopher Schlicksup, Joseph Wang, Samson Francis, Balasubramanian Venkatakrishnan, William Turner, Michael VanNieuwenhze, Adam Zlotnick, 2018, eLife on p. e31473

Hepatitis B virus core protein phosphorylation sites affect capsid stability and transient exposure of the C-terminal domain

Lisa Selzer, Ravi Kant, Joseph C.Y. Wang, Brian Bothner, Adam Zlotnick, 2015, Journal of Biological Chemistry on p. 28584-28593

Discovery of Exosomes From Tick Saliva and Salivary Glands Reveals Therapeutic Roles for CXCL12 and IL-8 in Wound Healing at the Tick–Human Skin Interface

Wenshuo Zhou, Faizan Tahir, Joseph Che Yen Wang, Michael Woodson, Michael Sherman, Shahid Karim, Girish Neelakanta, Hameeda Sultana, 2020, Frontiers in Cell and Developmental Biology on p. 554

PilT and PilU are homohexameric ATPases that coordinate to retract type IVa pili

Jennifer Chlebek, Hannah Hughes, Aleksandra Ratkiewicz, Rasman Rayyan, Joseph Che Yen Wang, Brittany Herrin, Triana Dalia, Nicolas Biais, Ankur Dalia, 2019, PLoS Genetics on p. e1008448

Importin β Can Bind Hepatitis B Virus Core Protein and Empty Core-Like Particles and Induce Structural Changes

Chao Chen, Joseph Wang, Elizabeth Pierson, David Keifer, Mildred Delaleau, Lara Gallucci, Christian Cazenave, Michael Kann, Martin Jarrold, Adam Zlotnick, 2016, PLoS Pathogens on p. e1005802

Charge Detection Mass Spectrometry Identifies Preferred Non-Icosahedral Polymorphs in the Self-Assembly of Woodchuck Hepatitis Virus Capsids

Elizabeth Pierson, David Keifer, Alexander Kukreja, Joseph Wang, Adam Zlotnick, Martin Jarrold, 2016, Journal of Molecular Biology on p. 292-300

ComM is a hexameric helicase that promotes branch migration during natural transformation in diverse Gram-negative species

Thomas Nero, Triana Dalia, Joseph Wang, David Kysela, Matthew Bochman, Ankur Dalia, 2018, Nucleic Acids Research on p. 6099-6111

Yeast Hrq1 shares structural and functional homology with the disease-linked human RecQ4 helicase

Cody Rogers, Joseph Che Yen Wang, Hiroki Noguchi, Tsuyoshi Imasaki, Yuichiro Takagi, Matthew Bochman, 2017, Nucleic Acids Research on p. 5217-5230

Self-Assembly of an Alphavirus Core-like Particle Is Distinguished by Strong Intersubunit Association Energy and Structural Defects

Joseph Che Yen Wang, Chao Chen, Vamseedhar Rayaprolu, Suchetana Mukhopadhyay, Adam Zlotnick, 2015, ACS Nano on p. 8898-8906