Jong Yun

Professor of Pharmacology

Jong Yun

Huck Affiliations

Publication Tags

Sphingosine Kinase Apoptosis Therapeutics Membranes Neoplasms Ceramides Death Domain Receptor Signaling Adaptor Proteins Acute Myeloid Leukemia Caspase 8 N' ((1e) 1 (3,4 Dimethoxyphenyl)Ethylidene) 3 (4 Methoxyphenyl) Sphingosine 1 Phosphate Phosphotransferases Cell Line Cell Death Melanoma Proteins Myeloid Cells Sphingosine Sphingolipids Growth Autophagy Cells Vorinostat Isothiocyanic Acid Histone Deacetylase Inhibitors

Most Recent Papers

Transdifferentiation of Human Circulating Monocytes Into Neuronal-Like Cells in 20 Days and Without Reprograming

Alfredo Bellon, Amelie Wegener, Adam R. Lescallette, Michael Valente, Seung Kwon Yang, Robert Gardette, Julien Matricon, Faycal Mouaffak, Paula Watts, Lene Vimeux, Jong K. Yun, Yuka Imamura Kawasawa, Gary A. Clawson, Elisabeta Blandin, Boris Chaumette, Therese M. Jay, Marie Odile Krebs, Vincent Feuillet, Anne Hosmalin, 2018, Frontiers in Molecular Neuroscience

SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models

Jeremy Hengst, Taryn E. Dick, Arati Sharma, Kenichiro Doi, Shailaja Hegde, Su Fern Tan, Laura Geffert, Todd E. Fox, Arun K. Sharma, Dhimant Desai, Shantu Amin, Mark Kester, Thomas P. Loughran, Robert Paulson, David Claxton, Hong-Gang Wang, Jong Yun, 2017, Cancer Translational Medicine on p. 109-121

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

Megan M. Young, Yoshinori Takahashi, Todd E. Fox, Jong K. Yun, Mark Kester, Hong Gang Wang, 2016, Cell Reports on p. 1532-1545

Acid ceramidase is upregulated in AML and represents a novel therapeutic target

Su Fern Tan, Xin Liu, Todd E. Fox, Brian M. Barth, Arati Sharma, Stephen D. Turner, Andy Awwad, Alden Dewey, Kenichiro Doi, Barbara Spitzer, Mithun Vinod Shah, Samy A.F. Morad, Dhimant Desai, Shantu Amin, Junjia Zhu, Jason Liao, Jong Yun, Mark Kester, David F. Claxton, Hong Gang Wang, Myles C. Cabot, Edward H. Schuchman, Ross L. Levine, David J. Feith, Thomas P. Loughran, 2016, Oncotarget on p. 83208-83222

Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia

Francis R. LeBlanc, Xin Liu, Jeremy Hengst, Todd Fox, Valerie Calvert, Emanuel F. Petricoin, Jong Yun, David J. Feith, Thomas P. Loughran, 2015, Cancer Biology and Therapy on p. 1830-1840

The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines

Taryn E. Dick, Jeremy A. Hengst, Todd E. Fox, Ashley L. Colledge, Vijay P. Kale, Shen Shu Sung, Arun Sharma, Shantu Amin, Thomas P. Loughran, Mark Kester, Hong Gang Wang, Jong K. Yun, 2015, Journal of Pharmacology and Experimental Therapeutics on p. 494-508

A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion

Vijay Pralhad Kale, Jeremy Hengst, Dhimant Desai, Taryn E. Dick, Katherine N. Choe, Ashley L. Colledge, Yoshinori Takahashi, Shen-shu Sung, Shantu Amin, Jong Yun, 2014, Cancer Letters on p. 299-310

Gβ2 and Gβ4 participate in the opioid and adrenergic receptor-mediated Ca<sup>2+</sup> channel modulation in rat sympathetic neurons

Saifeldin Mahmoud, Jong K. Yun, Victor Ruiz-Velasco, 2012, Journal of Physiology on p. 4673-4689

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

Megan M. Young, Yoshinori Takahashi, Osman Khan, Sungman Park, Tsukasa Hori, Jong Yun, Arun K. Sharma, Shantu Amin, Chang Deng Hu, Jianke Zhang, Mark Kester, Hong Gang Wang, 2012, Journal of Biological Chemistry on p. 12455-12468

Targeting sphingosine kinase-1 to inhibit melanoma

Subbarao V. Madhunapantula, Jeremy Hengst, Raghavendra Gowda, Todd E. Fox, Jong K. Yun, Gavin P. Robertson, 2012, Pigment Cell and Melanoma Research on p. 259-274

Most-Cited Papers

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

Megan M. Young, Yoshinori Takahashi, Osman Khan, Sungman Park, Tsukasa Hori, Jong Yun, Arun K. Sharma, Shantu Amin, Chang Deng Hu, Jianke Zhang, Mark Kester, Hong Gang Wang, 2012, Journal of Biological Chemistry on p. 12455-12468

Targeting sphingosine kinase-1 to inhibit melanoma

Subbarao V. Madhunapantula, Jeremy Hengst, Raghavendra Gowda, Todd E. Fox, Jong K. Yun, Gavin P. Robertson, 2012, Pigment Cell and Melanoma Research on p. 259-274

Development of a sphingosine kinase 1 specific small-molecule inhibitor

Jeremy Hengst, Xujun Wang, Ugir H. Sk, Arun Sharma, Shantu Amin, Jong Yun, 2010, Bioorganic and Medicinal Chemistry Letters on p. 7498-7502

Acid ceramidase is upregulated in AML and represents a novel therapeutic target

Su Fern Tan, Xin Liu, Todd E. Fox, Brian M. Barth, Arati Sharma, Stephen D. Turner, Andy Awwad, Alden Dewey, Kenichiro Doi, Barbara Spitzer, Mithun Vinod Shah, Samy A.F. Morad, Dhimant Desai, Shantu Amin, Junjia Zhu, Jason Liao, Jong Yun, Mark Kester, David F. Claxton, Hong Gang Wang, Myles C. Cabot, Edward H. Schuchman, Ross L. Levine, David J. Feith, Thomas P. Loughran, 2016, Oncotarget on p. 83208-83222

Selenium-containing analogs of SAHA induce cytotoxicity in lung cancer cells

Nilkamal Karelia, Dhimant Desai, Jeremy Hengst, Shantu Amin, Sairam V. Rudrabhatla, Jong Yun, 2010, Bioorganic and Medicinal Chemistry Letters on p. 6816-6819

Inhibition of eEF-2 kinase sensitizes human glioma cells to TRAIL and down-regulates Bcl-xL expression

Yi Zhang, Yan Cheng, Li Zhang, Xingcong Ren, Kathryn J. Huber-Keener, Sang Lee, Jong Yun, Hong Gang Wang, Jin Ming Yang, 2011, Biochemical and Biophysical Research Communications on p. 129-134

Development of novel naphthalimide derivatives and their evaluation as potential melanoma therapeutics

Ugir Hossain Sk, A. S. Prakasha Gowda, Melissa A. Crampsie, Jong K. Yun, Thomas E. Spratt, Shantu Amin, Arun K. Sharma, 2011, European Journal of Medicinal Chemistry on p. 3331-3338

The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines

Taryn E. Dick, Jeremy A. Hengst, Todd E. Fox, Ashley L. Colledge, Vijay P. Kale, Shen Shu Sung, Arun Sharma, Shantu Amin, Thomas P. Loughran, Mark Kester, Hong Gang Wang, Jong K. Yun, 2015, Journal of Pharmacology and Experimental Therapeutics on p. 494-508

Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs

Arun K. Sharma, Ugir Hossain Sk, Melissa A. Gimbor, Jeremy A. Hengst, Xujun Wang, Jong Yun, Shantu Amin, 2010, European Journal of Medicinal Chemistry on p. 4149-4156

AP-1 binding transcriptionally regulates human neutral ceramidase

Sean M. O'Neill, Kristy L. Houck, Jong K. Yun, Todd E. Fox, Mark Kester, 2011, Archives of Biochemistry and Biophysics on p. 31-39