Jong Yun

Professor of Pharmacology

Hershey Med Ctr
Hershey,
jky1@psu.edu

Bio & Links
Publications

Huck Affiliations

Center for Molecular Toxicology and Carcinogenesis

Publication Tags

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Sphingosine Kinase Sphingosine Therapeutics Cell Migration Immunogenic Cell Death Polymerization Membranes Cell Invasion Cancer Cell Calreticulin Kinase Myeloid Phosphotransferase Sphingosine 1 Phosphate Neoplasms Ceramides Sphingolipids Acute Myeloid Leukemia Protein Isoforms Ceramide Phosphotransferases N' ((1e) 1 (3,4 Dimethoxyphenyl)Ethylidene) 3 (4 Methoxyphenyl) Autophagy Mitoxantrone Monocytes

Most Recent Publications

Fanning the Flames of Endoplasmic Reticulum (ER) Stress: Can Sphingolipid Metabolism Be Targeted to Enhance ER Stress–Associated Immunogenic Cell Death in Cancer?

Jeremy A. Hengst, Asvelt J. Nduwumwami, Arati Sharma, Jong K. Yun, 2024, Molecular Pharmacology on p. 155-165

Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective Inhibitor of ROCK and MRCK Kinases

Vijay Pralhad Kale, Jeremy A. Hengst, Arati K. Sharma, Upendarrao Golla, Sinisa Dovat, Shantu G. Amin, Jong K. Yun, Dhimant H. Desai, 2023, Pharmaceuticals

Regulatory Role of Sphingosine-1-Phosphate and C16:0 Ceramide, in Immunogenic Cell Death of Colon Cancer Cells Induced by Bak/Bax-Activation

Jeremy A. Hengst, Asvelt J. Nduwumwami, Jong K. Yun, 2022, Cancers

Inhibition of Sphingosine Kinase Activity Enhances Immunogenic Cell Surface Exposure of Calreticulin Induced by the Synthetic Cannabinoid 5-epi-CP-55,940

Jeremy A. Hengst, Asvelt J. Nduwumwami, Wesley M. Raup-Konsavage, Kent E. Vrana, Jong Yun, 2022, Cannabis and Cannabinoid Research on p. 637-647

Sphingosine kinase inhibition enhances dimerization of calreticulin at the cell surface in mitoxantrone-induced immunogenic cell death

Asvelt J. Nduwumwami, Jeremy A. Hengst, Jong K. Yun, 2021, Journal of Pharmacology and Experimental Therapeutics on p. 300-310

Development of SKI-349, a dual-targeted inhibitor of sphingosine kinase and microtubule polymerization

Jeremy A. Hengst, Shailaja Hegde, Robert F. Paulson, Jong K. Yun, 2020, Bioorganic and Medicinal Chemistry Letters

Analysis of selective target engagement by small-molecule sphingosine kinase inhibitors using the Cellular Thermal Shift Assay (CETSA)

Jeremy A. Hengst, Taryn E. Dick, Charles D. Smith, Jong K. Yun, 2020, Cancer Biology and Therapy on p. 841-852

Transdifferentiation of Human Circulating Monocytes Into Neuronal-Like Cells in 20 Days and Without Reprograming

Alfredo Bellon, Amelie Wegener, Adam R. Lescallette, Michael Valente, Seung Kwon Yang, Robert Gardette, Julien Matricon, Faycal Mouaffak, Paula Watts, Lene Vimeux, Jong K. Yun, Yuka Imamura Kawasawa, Gary A. Clawson, Elisabeta Blandin, Boris Chaumette, Therese M. Jay, Marie Odile Krebs, Vincent Feuillet, Anne Hosmalin, 2018, Frontiers in Molecular Neuroscience

SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models

Jeremy Hengst, T Dick, Arati Sharma, K Doi, S Hegde, S Tan, L Geffert, T Fox, Arun K. Sharma, Dhimant Desai, Shantu Amin, M Kester, T Loughran, Robert Paulson, David Claxton, Hong-Gang Wang, Jong Yun, 2017, Cancer Translational Medicine on p. 109-121

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

Megan M. Young, Yoshinori Takahashi, Todd E. Fox, Jong K. Yun, Mark Kester, Hong Gang Wang, 2016, Cell Reports on p. 1532-1545

Most-Cited Papers

Acid ceramidase is upregulated in AML and represents a novel therapeutic target

Su Fern Tan, Xin Liu, Todd E. Fox, Brian M. Barth, Arati Sharma, Stephen D. Turner, Andy Awwad, Alden Dewey, Kenichiro Doi, Barbara Spitzer, Mithun Vinod Shah, Samy A.F. Morad, Dhimant Desai, Shantu Amin, Junjia Zhu, Jason Liao, Jong Yun, Mark Kester, David F. Claxton, Hong Gang Wang, Myles C. Cabot, Edward H. Schuchman, Ross L. Levine, David J. Feith, Thomas P. Loughran, 2016, Oncotarget on p. 83208-83222

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

Megan M. Young, Yoshinori Takahashi, Todd E. Fox, Jong K. Yun, Mark Kester, Hong Gang Wang, 2016, Cell Reports on p. 1532-1545

The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration

Vijay Pralhad Kale, Jeremy A. Hengst, Dhimant H. Desai, Shantu G. Amin, Jong K. Yun, 2015, Cancer Letters on p. 185-196

The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines

Taryn E. Dick, Jeremy A. Hengst, Todd E. Fox, Ashley L. Colledge, Vijay P. Kale, Shen Shu Sung, Arun Sharma, Shantu Amin, Thomas P. Loughran, Mark Kester, Hong Gang Wang, Jong K. Yun, 2015, Journal of Pharmacology and Experimental Therapeutics on p. 494-508

Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia

Francis R. LeBlanc, Xin Liu, Jeremy Hengst, Todd Fox, Valerie Calvert, Emanuel F. Petricoin, Jong Yun, David J. Feith, Thomas P. Loughran, 2015, Cancer Biology and Therapy on p. 1830-1840

A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion

Vijay Pralhad Kale, Jeremy A. Hengst, Dhimant H. Desai, Taryn E. Dick, Katherine N. Choe, Ashley L. Colledge, Yoshinori Takahashi, Shen Shu Sung, Shantu G. Amin, Jong K. Yun, 2014, Cancer Letters on p. 299-310