Jianming Hu
Professor of Microbiology and Immunology

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H107 Microbiology & Immunology
Hershey, PA - juh13@psu.edu
- 717-531-6523
Huck Affiliations
Publication Tags
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Hepatitis B Virus Circular Dna Genome Hepatitis B Virion Capsid Nucleocapsid Therapeutics Proteins Genes Dna Antiviral Agents Degradation Raman Spectroscopy Chromium Stabilization Rna Directed Dna Polymerase Virus Diseases Infection Chronic Hepatitis B Rna Virus Replication Lysine Tyrosyl Dna Phosphodiesterase SerumMost Recent Publications
Hepatitis B Virus Capsid: The Core in Productive Entry and Covalently Closed Circular DNA Formation
Megan A. Mendenhall, Xupeng Hong, Jianming Hu, 2023, Viruses
Characterization of Intracellular Precore-Derived Proteins and Their Functions in Hepatitis B Virus-Infected Human Hepatocytes
Xupeng Hong, Emily N. Bianchini, Joseph Che Yen Wang, Jianming Hu, 2023, mBio
Nomenclature of HBV core protein-targeting antivirals
Fabien Zoulim, Adam Zlotnick, Stephanie Buchholz, Eric Donaldson, John Fry, Anuj Gaggar, Jianming Hu, Michael Kann, Oliver Lenz, Kai Lin, Nagraj Mani, Michael Nassal, William Delaney, Su Wang, Gabriel Westman, Veronica Miller, Harry L.A. Janssen, 2022, Nature Reviews Gastroenterology and Hepatology on p. 748-750
A roadmap for serum biomarkers for hepatitis B virus: current status and future outlook
Anna Kramvis, Kyong Mi Chang, Maura Dandri, Patrizia Farci, Dieter Glebe, Jianming Hu, Harry L.A. Janssen, Daryl T.Y. Lau, Capucine Penicaud, Teresa Pollicino, Barbara Testoni, Florian Van Bömmel, Ourania Andrisani, Maria Beumont-Mauviel, Timothy M. Block, Henry L.Y. Chan, Gavin A. Cloherty, William E. Delaney, Anna Maria Geretti, Adam Gehring, Kathy Jackson, Oliver Lenz, Mala K. Maini, Veronica Miller, Ulrike Protzer, Jenny C. Yang, Man Fung Yuen, Fabien Zoulim, Peter A. Revill, 2022, Nature Reviews Gastroenterology and Hepatology on p. 727-745
Conserved Lysine Residues of Hepatitis B Virus Core Protein Are Not Required for Covalently Closed Circular DNA Formation
Xupeng Hong, Jianming Hu, 2022, Journal of Virology
Constrained evolution of overlapping genes in viral host adaptation: Acquisition of glycosylation motifs in hepadnaviral precore/ core genes
Xupeng Hong, Stephan Menne, Jianming Hu, 2022, PLoS Pathogens
Host cell-dependent late entry step as determinant of Hepatitis B virus infection
Xupeng Hong, Yuka Imamura Kawasawa, Stephan Menne, Jianming Hu, 2022, PLoS Pathogens
Region-Specific Hepatitis B Virus Genome Exposure from Nucleocapsid Modulated by Capsid Linker Sequence and Inhibitor: Implications for Uncoating
Ji Xi, Xiuji Cui, Kuancheng Liu, Haitao Liu, Joseph Wang, Jianming Hu, 2022, Journal of Virology on p. e00399-22
Regulation of Hepatitis B Virus Virion Release and Envelopment Timing by Nucleocapsid and Envelope Interactions
Ji Xi, Haitao Liu, Jianming Hu, 2022, Journal of Virology
Cryo-EM structures of human hepatitis B and woodchuck hepatitis virus small spherical subviral particles
Haitao Liu, Xupeng Hong, Ji Xi, Stephan Menne, Jianming Hu, Joseph Che-Yen Wang, 2022, Science advances on p. eabo4184
Most-Cited Papers
A global scientific strategy to cure hepatitis B
Peter A. Revill, Francis V. Chisari, Joan M. Block, Maura Dandri, Adam J. Gehring, Haitao Guo, Jianming Hu, Anna Kramvis, Pietro Lampertico, Harry L.A. Janssen, Massimo Levrero, Wenhui Li, T. Jake Liang, Seng Gee Lim, Fengmin Lu, M. Capucine Penicaud, John E. Tavis, Robert Thimme, Patrick Arbuthnot, Andre Boonstra, Kyong Mi Chang, Per Jei Chen, Dieter Glebe, Luca G. Guidotti, Jacques Fellay, Carlo Ferrari, Louis Jansen, Daryl T.Y. Lau, Anna S. Lok, Mala K. Maini, William Mason, Gail Matthews, Dimitrios Paraskevis, Jörg Petersen, Barbara Rehermann, Eui Cheol Shin, Alex Thompson, Florian van Bömmel, Fu Sheng Wang, Koichi Watashi, Hung Chih Yang, Zhenghong Yuan, Man Fung Yuen, Timothy Block, Veronica Miller, Ulrike Protzer, Christian Bréchot, Stephen Locarnini, Marion G. Peters, Raymond F. Schinazi, 2019, The Lancet Gastroenterology and Hepatology on p. 545-558
Complete and incomplete hepatitis B virus particles: Formation, function, and application
Jianming Hu, Kuancheng Liu, 2017, Viruses
Raman Spectroscopy, Photocatalytic Degradation, and Stabilization of Atomically Thin Chromium Tri-iodide
D. Shcherbakov, P. Stepanov, D. Weber, Y. Wang, J. Hu, Y. Zhu, K. Watanabe, T. Taniguchi, Z. Mao, W. Windl, J. Goldberger, M. Bockrath, C.N. Lau, 2018, Nano Letters on p. 4214-4219
Hepadnavirus genome replication and persistence
Jianming Hu, Christoph Seeger, 2015, Cold Spring Harbor perspectives in medicine
Revisiting Hepatitis B virus: Challenges of curative therapies
Jianming Hu, Ulrike Protzer, Aleem Siddiqui, 2019, Journal of Virology
Does tyrosyl DNA phosphodiesterase-2 play a role in hepatitis B virus genome repair?
Xiuji Cui, Rebecca McAllister, Rajeev Boregowda, Ji A. Sohn, Felipe Cortes Ledesma, Keith W. Caldecott, Christoph Seeger, Jianming Hu, 2015, PLoS One
Genome-free hepatitis B virion levels in patient sera as a potential marker to monitor response to antiviral therapy
L. Luckenbaugh, K. M. Kitrinos, W. E. Delaney, J. Hu, 2015, Journal of Viral Hepatitis on p. 561-570
Hepatitis B virus reverse transcriptase - Target of current antiviral therapy and future drug development
Daniel N. Clark, Jianming Hu, 2015, Antiviral Research on p. 132-137
A research agenda for curing chronic hepatitis B virus infection
Harvey Alter, Timothy Block, Nathaniel Brown, Alan Brownstein, Carol Brosgart, Kyong Mi Chang, Pei Jer Chen, Francis V. Chisari, Chari Cohen, Hashem El-Serag, Jordan Feld, Robert Gish, Jeffrey Glenn, Tim Greten, Haitao Guo, Ju Tao Guo, Yujin Hoshida, Jianming Hu, Kris V. Kowdley, Wenhui Li, Jake Liang, Stephan Locarnini, Anna S. Lok, William Mason, Brian McMahon, Anand Mehta, Robert Perrillo, Peter Revill, Charles M. Rice, Jo Ann Rinaudo, Raymond Schinazi, Christoph Seeger, Kirty Shetty, John Tavis, Fabien Zoulim, 2018, Hepatology on p. 1127-1131
Cell and Animal Models for Studying Hepatitis B Virus Infection and Drug Development
Jianming Hu, You Yu Lin, Pei Jer Chen, Koichi Watashi, Takaji Wakita, 2019, Gastroenterology on p. 338-354