Janine Kwapis

Assistant Professor of Biology

Janine Kwapis

Research Summary

Molecular and epigenetic mechanisms underlying learning and memory and age-related memory impairments.

Graduate Students

Huck Affiliations

Links

Publication Tags

Fear Amygdala Long Term Memory Conditioning (Psychology) Proteins Proteasome Endopeptidase Complex Genes Phosphorylation Cocaine Neuronal Plasticity Epigenomics Hippocampus Acetylation Proteolysis Calcium Calmodulin Dependent Protein Kinase Type 2 Prefrontal Cortex Data Storage Equipment Habenula Neurons Ubiquitin Gene Expression Anisomycin Calcium Histones Nucleosomes

Most Recent Papers

Aging mice show impaired memory updating in the novel OUL updating paradigm

Janine L. Kwapis, Yasaman Alaghband, Ashley A. Keiser, Tri N. Dong, Christina M. Michael, Diane Rhee, Guanhua Shu, Richard T. Dang, Dina P. Matheos, Marcelo A. Wood, 2020, Neuropsychopharmacology on p. 337-346

GluR2 endocytosis-dependent protein degradation in the amygdala mediates memory updating

Nicole C. Ferrara, Timothy J. Jarome, Patrick K. Cullen, Sabrina A. Orsi, Janine L. Kwapis, Sydney Trask, Shane E. Pullins, Fred J. Helmstetter, 2019, Scientific reports

Exercise opens a temporal window for enhanced cognitive improvement from subsequent physical activity

Christopher W. Butler, Ashley A. Keiser, Janine L. Kwapis, Nicole C. Berchtold, Vanessa L. Wall, Marcelo A. Wood, Carl W. Cotman, 2019, Learning & memory (Cold Spring Harbor, N.Y.) on p. 485-492

Epigenetic regulation of immediate-early gene Nr4a2/Nurr1 in the medial habenula during reinstatement of cocaine-associated behavior

Alberto J. López, Thekla J. Hemstedt, Yousheng Jia, Philip H. Hwang, Rianne R. Campbell, Janine L. Kwapis, Andre O. White, Om Chitnis, Vanessa M. Scarfone, Dina P. Matheos, Gary Lynch, Marcelo A. Wood, 2019, Neuropharmacology on p. 13-19

PP4-dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure

Arnau Hervera, Luming Zhou, Ilaria Palmisano, Eilidh McLachlan, Guiping Kong, Thomas H. Hutson, Matt C. Danzi, Vance P. Lemmon, John L. Bixby, Andreu Matamoros-Angles, Kirsi Forsberg, Francesco De Virgiliis, Dina P. Matheos, Janine Kwapis, Marcelo A. Wood, Radhika Puttagunta, José Antonio del Río, Simone Di Giovanni, 2019, EMBO Journal

HDAC3-mediated repression of the Nr4a family contributes to age-related impairments in long-term memory

Janine L. Kwapis, Yasaman Alaghband, Alberto J. López, Jeffrey M. Long, Xiang Li, Guanhua Shu, Kasuni K. Bodinayake, Dina P. Matheos, Peter R. Rapp, Marcelo A. Wood, 2019, Journal of Neuroscience on p. 4999-5009

Medial habenula cholinergic signaling regulates cocaine-associated relapse-like behavior

Alberto J. López, Yousheng Jia, André O. White, Janine L. Kwapis, Monica Espinoza, Philip Hwang, Rianne Campbell, Yasaman Alaghband, Om Chitnis, Dina P. Matheos, Gary Lynch, Marcelo A. Wood, 2019, Addiction Biology on p. 403-413

Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory

Janine L. Kwapis, Yasaman Alaghband, Enikö A. Kramár, Alberto J. López, Annie Vogel Ciernia, André O. White, Guanhua Shu, Diane Rhee, Christina M. Michael, Emilie Montellier, Yu Liu, Christophe N. Magnan, Siwei Chen, Paolo Sassone-Corsi, Pierre Baldi, Dina P. Matheos, Marcelo A. Wood, 2018, Nature communications

CREST in the nucleus accumbens core regulates cocaine conditioned place preference, cocaine-seeking behavior, and synaptic plasticity

Yasaman Alaghband, Enikö Kramár, Janine L. Kwapis, Earnest S. Kim, Thekla J. Hemstedt, Alberto J. López, André O. White, Amni Al-Kachak, Osasumwen V. Aimiuwu, Kasuni K. Bodinayake, Nicole C. Oparaugo, Joseph Han, K. Matthew Lattal, Marcelo A. Wood, 2018, Journal of Neuroscience on p. 9514-9526

Deleting HDAC3 rescues long-term memory impairments induced by disruption of the neuronspecific chromatin remodeling subunit BAF53b

Guanhua Shu, Enikö A. Kramár, Alberto J. López, Grace Huynh, Marcelo A. Wood, Janine Kwapis, 2018, Learning and Memory on p. 109-114

Most-Cited Papers

Activity dependent protein degradation is critical for the formation and stability of fear memory in the amygdala

Timothy J. Jarome, Craig T. Werner, Janine L. Kwapis, Fred J. Helmstetter, 2011, PloS one

Trace and contextual fear conditioning are impaired following unilateral microinjection of muscimol in the ventral hippocampus or amygdala, but not the medial prefrontal cortex

Marieke R. Gilmartin, Janine Kwapis, Fred J. Helmstetter, 2012, Neurobiology of Learning and Memory on p. 452-464

CaMKII, but not protein kinase A, regulates Rpt6 phosphorylation and proteasome activity during the formation of long-term memories

Timothy J. Jarome, Janine L. Kwapis, Wendy L. Ruenzel, Fred J. Helmstetter, 2013, Frontiers in Behavioral Neuroscience

NR2A- and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioning

Marieke R. Gilmartin, Janine L. Kwapis, Fred J. Helmstetter, 2013, Learning and Memory on p. 290-294

CaMKII regulates proteasome phosphorylation and activity and promotes memory destabilization following retrieval

Timothy J. Jarome, Nicole C. Ferrara, Janine Kwapis, Fred J. Helmstetter, 2016, Neurobiology of Learning and Memory on p. 103-109

Memory consolidation in both trace and delay fear conditioning is disrupted by intra-amygdala infusion of the protein synthesis inhibitor anisomycin.

Janine Kwapis, Timothy J. Jarome, Janet C. Schiff, Fred J. Helmstetter, 2011, Learning & memory (Cold Spring Harbor, N.Y.) on p. 728-732

Promoter-specific effects of DREADD modulation on hippocampal synaptic plasticity and memory formation

Alberto J. López, Enikö Kramár, Dina P. Matheos, André O. White, Janine Kwapis, Annie Vogel-Ciernia, Keith Sakata, Monica Espinoza, Marcelo A. Wood, 2016, Journal of Neuroscience on p. 3588-3599

The timing of multiple retrieval events can alter GluR1 phosphorylation and the requirement for protein synthesis in fear memory reconsolidation

Timothy J. Jarome, Janine Kwapis, Craig T. Werner, Ryan G. Parsons, Georgette M. Gafford, Fred J. Helmstetter, 2012, Learning and Memory on p. 300-306

The retrosplenial cortex is involved in the formation of memory for context and trace fear conditioning

Janine Kwapis, Timothy J. Jarome, Jonathan L. Lee, Fred J. Helmstetter, 2015, Neurobiology of Learning and Memory on p. 110-116

Extinguishing trace fear engages the retrosplenial cortex rather than the amygdala

Janine L. Kwapis, Timothy J. Jarome, Jonathan L. Lee, Marieke R. Gilmartin, Fred J. Helmstetter, 2014, Neurobiology of Learning and Memory on p. 41-54