Janine Kwapis
Assistant Professor of Biology

-
516 Mueller Lab
University Park, PA - She/Her
- jlk855@psu.edu
Research Summary
Molecular and epigenetic mechanisms underlying learning and memory and age-related memory impairments.
Huck Graduate Students
Huck Affiliations
- Molecular, Cellular, and Integrative Biosciences
- Neuroscience
- Center for Molecular Investigation of Neurological Disorders
- Center for Brain, Behavior, and Cognition
Links
Publication Tags
Memory Fear Amygdala Long Term Memory Conditioning (Psychology) Proteins Proteasome Endopeptidase Complex Genes Phosphorylation Hippocampus Proteolysis Epigenomics Calcium Calmodulin Dependent Protein Kinase Type 2 Data Storage Equipment Prefrontal Cortex Cocaine Habenula Ubiquitin Anisomycin Neurons Neuronal Plasticity Gene Expression Acetylation Learning RecurrenceMost Recent Papers
Molecular Mechanisms of Reconsolidation-Dependent Memory Updating.
L Bellfy, Janine Kwapis, 2020, International journal of molecular sciences
Investigating memory updating in mice using the objects in updated locations task
Destiny S. Wright, Kasuni K. Bodinayake, Janine L. Kwapis, 2020, Current Protocols in Neuroscience
Aging mice show impaired memory updating in the novel OUL updating paradigm
Janine L. Kwapis, Yasaman Alaghband, Ashley A. Keiser, Tri N. Dong, Christina M. Michael, Diane Rhee, Guanhua Shu, Richard T. Dang, Dina P. Matheos, Marcelo A. Wood, 2020, Neuropsychopharmacology on p. 337-346
A neuroscientist's guide to transgenic mice and other genetic tools.
Shaghayegh Navabpour, Janine Kwapis, Timothy Jarome, 2020, Neuroscience and biobehavioral reviews on p. 732-748
GluR2 endocytosis-dependent protein degradation in the amygdala mediates memory updating
Nicole C. Ferrara, Timothy J. Jarome, Patrick K. Cullen, Sabrina A. Orsi, Janine L. Kwapis, Sydney Trask, Shane E. Pullins, Fred J. Helmstetter, 2019, Scientific Reports on p. 5180
Exercise opens a temporal window for enhanced cognitive improvement from subsequent physical activity
Christopher W. Butler, Ashley A. Keiser, Janine L. Kwapis, Nicole C. Berchtold, Vanessa L. Wall, Marcelo A. Wood, Carl W. Cotman, 2019, Learning and Memory on p. 485-492
Epigenetic regulation of immediate-early gene Nr4a2/Nurr1 in the medial habenula during reinstatement of cocaine-associated behavior
Alberto J. López, Thekla J. Hemstedt, Yousheng Jia, Philip H. Hwang, Rianne R. Campbell, Janine L. Kwapis, Andre O. White, Om Chitnis, Vanessa M. Scarfone, Dina P. Matheos, Gary Lynch, Marcelo A. Wood, 2019, Neuropharmacology on p. 13-19
PP4-dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure
Arnau Hervera, Luming Zhou, Ilaria Palmisano, Eilidh McLachlan, Guiping Kong, Thomas H. Hutson, Matt C. Danzi, Vance P. Lemmon, John L. Bixby, Andreu Matamoros-Angles, Kirsi Forsberg, Francesco De Virgiliis, Dina P. Matheos, Janine Kwapis, Marcelo A. Wood, Radhika Puttagunta, José Antonio del Río, Simone Di Giovanni, 2019, EMBO Journal
HDAC3-mediated repression of the Nr4a family contributes to age-related impairments in long-term memory
Janine L. Kwapis, Yasaman Alaghband, Alberto J. López, Jeffrey M. Long, Xiang Li, Guanhua Shu, Kasuni K. Bodinayake, Dina P. Matheos, Peter R. Rapp, Marcelo A. Wood, 2019, Journal of Neuroscience on p. 4999-5009
Medial habenula cholinergic signaling regulates cocaine-associated relapse-like behavior.
A López, Y Jia, A White, Janine Kwapis, M Espinoza, P Hwang, Robert Campbell, Y Alaghband, O Chitnis, D Matheos, G Lynch, M Wood, 2019, Addiction Biology on p. 403-413
Most-Cited Papers
Activity dependent protein degradation is critical for the formation and stability of fear memory in the amygdala
Timothy J. Jarome, Craig T. Werner, Janine L. Kwapis, Fred J. Helmstetter, 2011, PLoS One on p. e24349
Trace and contextual fear conditioning are impaired following unilateral microinjection of muscimol in the ventral hippocampus or amygdala, but not the medial prefrontal cortex
Marieke R. Gilmartin, Janine Kwapis, Fred J. Helmstetter, 2012, Neurobiology of Learning and Memory on p. 452-464
CaMKII regulates proteasome phosphorylation and activity and promotes memory destabilization following retrieval
Timothy J. Jarome, Nicole C. Ferrara, Janine Kwapis, Fred J. Helmstetter, 2016, Neurobiology of Learning and Memory on p. 103-109
CaMKII, but not protein kinase A, regulates Rpt6 phosphorylation and proteasome activity during the formation of long-term memories
Timothy J. Jarome, Janine L. Kwapis, Wendy L. Ruenzel, Fred J. Helmstetter, 2013, Frontiers in Behavioral Neuroscience
Promoter-specific effects of DREADD modulation on hippocampal synaptic plasticity and memory formation
Alberto J. López, Enikö Kramár, Dina P. Matheos, André O. White, Janine Kwapis, Annie Vogel-Ciernia, Keith Sakata, Monica Espinoza, Marcelo A. Wood, 2016, Journal of Neuroscience on p. 3588-3599
NR2A- and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioning
Marieke R. Gilmartin, Janine L. Kwapis, Fred J. Helmstetter, 2013, Learning and Memory on p. 290-294
Memory consolidation in both trace and delay fear conditioning is disrupted by intra-amygdala infusion of the protein synthesis inhibitor anisomycin.
Janine L. Kwapis, Timothy J. Jarome, Janet C. Schiff, Fred J. Helmstetter, 2011, Learning and Memory on p. 728-732
The retrosplenial cortex is involved in the formation of memory for context and trace fear conditioning
Janine Kwapis, Timothy J. Jarome, Jonathan L. Lee, Fred J. Helmstetter, 2015, Neurobiology of Learning and Memory on p. 110-116
Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory.
Janine Kwapis, Y Alaghband, E Kramár, A López, A Vogel Ciernia, A White, G Shu, D Rhee, C Michael, E Montellier, Y Liu, C Magnan, Shu-Jen Chen, P Sassone-Corsi, P Baldi, D Matheos, M Wood, 2018, Nature Communications on p. 3323
The timing of multiple retrieval events can alter GluR1 phosphorylation and the requirement for protein synthesis in fear memory reconsolidation
Timothy J. Jarome, Janine Kwapis, Craig T. Werner, Ryan G. Parsons, Georgette M. Gafford, Fred J. Helmstetter, 2012, Learning and Memory on p. 300-306