Janine Kwapis

Assistant Professor of Biology

Janine Kwapis

Research Summary

Molecular and epigenetic mechanisms underlying learning and memory and age-related memory impairments.

Huck Graduate Students

Huck Affiliations


Publication Tags

Memory Fear Amygdala Conditioning (Psychology) Long Term Memory Genes Proteins Data Storage Equipment Proteasome Endopeptidase Complex Epigenomics Hippocampus Proteolysis Calcium Calmodulin Dependent Protein Kinase Type 2 Prefrontal Cortex Phosphorylation Ubiquitin Gene Expression Neurons Neuronal Plasticity Acetylation Cognition Animals Degradation Learning Memory Consolidation

Most Recent Papers

Special issue “molecular mechanisms of memory formation and modification”

Timothy J. Jarome, Janine L. Kwapis, 2021, International Journal of Molecular Sciences

Molecular mechanisms of reconsolidation-dependent memory updating

Lauren Bellfy, Janine L. Kwapis, 2020, International Journal of Molecular Sciences on p. 1-18

Investigating memory updating in mice using the objects in updated locations task

Destiny S. Wright, Kasuni K. Bodinayake, Janine L. Kwapis, 2020, Current Protocols in Neuroscience

A neuroscientist's guide to transgenic mice and other genetic tools

Shaghayegh Navabpour, Janine L. Kwapis, Timothy J. Jarome, 2020, Neuroscience and Biobehavioral Reviews on p. 732-748

Aging mice show impaired memory updating in the novel OUL updating paradigm

Janine L. Kwapis, Yasaman Alaghband, Ashley A. Keiser, Tri N. Dong, Christina M. Michael, Diane Rhee, Guanhua Shu, Richard T. Dang, Dina P. Matheos, Marcelo A. Wood, 2020, Neuropsychopharmacology on p. 337-346

GluR2 endocytosis-dependent protein degradation in the amygdala mediates memory updating

Nicole C. Ferrara, Timothy J. Jarome, Patrick K. Cullen, Sabrina A. Orsi, Janine L. Kwapis, Sydney Trask, Shane E. Pullins, Fred J. Helmstetter, 2019, Scientific Reports on p. 5180

Exercise opens a temporal window for enhanced cognitive improvement from subsequent physical activity

Christopher W. Butler, Ashley A. Keiser, Janine L. Kwapis, Nicole C. Berchtold, Vanessa L. Wall, Marcelo A. Wood, Carl W. Cotman, 2019, Learning and Memory on p. 485-492

Epigenetic regulation of immediate-early gene Nr4a2/Nurr1 in the medial habenula during reinstatement of cocaine-associated behavior

Alberto J. López, Thekla J. Hemstedt, Yousheng Jia, Philip H. Hwang, Rianne R. Campbell, Janine L. Kwapis, Andre O. White, Om Chitnis, Vanessa M. Scarfone, Dina P. Matheos, Gary Lynch, Marcelo A. Wood, 2019, Neuropharmacology on p. 13-19

PP4-dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure

Arnau Hervera, Luming Zhou, Ilaria Palmisano, Eilidh McLachlan, Guiping Kong, Thomas H. Hutson, Matt C. Danzi, Vance P. Lemmon, John L. Bixby, Andreu Matamoros-Angles, Kirsi Forsberg, Francesco De Virgiliis, Dina P. Matheos, Janine Kwapis, Marcelo A. Wood, Radhika Puttagunta, José Antonio del Río, Simone Di Giovanni, 2019, EMBO Journal

HDAC3-mediated repression of the Nr4a family contributes to age-related impairments in long-term memory

Janine L. Kwapis, Yasaman Alaghband, Alberto J. López, Jeffrey M. Long, Xiang Li, Guanhua Shu, Kasuni K. Bodinayake, Dina P. Matheos, Peter R. Rapp, Marcelo A. Wood, 2019, Journal of Neuroscience on p. 4999-5009

Most-Cited Papers

Activity dependent protein degradation is critical for the formation and stability of fear memory in the amygdala

Timothy J. Jarome, Craig T. Werner, Janine L. Kwapis, Fred J. Helmstetter, 2011, PLoS One on p. e24349

Trace and contextual fear conditioning are impaired following unilateral microinjection of muscimol in the ventral hippocampus or amygdala, but not the medial prefrontal cortex

Marieke R. Gilmartin, Janine Kwapis, Fred J. Helmstetter, 2012, Communications in behavioral biology. Part A: [Original articles] on p. 452-464

CaMKII regulates proteasome phosphorylation and activity and promotes memory destabilization following retrieval

Timothy J. Jarome, Nicole C. Ferrara, Janine Kwapis, Fred J. Helmstetter, 2016, Communications in behavioral biology. Part A: [Original articles] on p. 103-109

CaMKII, but not protein kinase A, regulates Rpt6 phosphorylation and proteasome activity during the formation of long-term memories

Timothy J. Jarome, Janine L. Kwapis, Wendy L. Ruenzel, Fred J. Helmstetter, 2013, Frontiers in Behavioral Neuroscience

Epigenetic mechanisms in fear conditioning

Janine L. Kwapis, Marcelo A. Wood, 2014, Trends in Neurosciences on p. 706-720

Promoter-specific effects of DREADD modulation on hippocampal synaptic plasticity and memory formation

Alberto J. López, Enikö Kramár, Dina P. Matheos, André O. White, Janine Kwapis, Annie Vogel-Ciernia, Keith Sakata, Monica Espinoza, Marcelo A. Wood, 2016, Journal of Neuroscience on p. 3588-3599

NR2A- and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioning

Marieke R. Gilmartin, Janine L. Kwapis, Fred J. Helmstetter, 2013, Learning and Memory on p. 290-294

Memory consolidation in both trace and delay fear conditioning is disrupted by intra-amygdala infusion of the protein synthesis inhibitor anisomycin.

Janine L. Kwapis, Timothy J. Jarome, Janet C. Schiff, Fred J. Helmstetter, 2011, Learning and Memory on p. 728-732

The retrosplenial cortex is involved in the formation of memory for context and trace fear conditioning

Janine Kwapis, Timothy J. Jarome, Jonathan L. Lee, Fred J. Helmstetter, 2015, Communications in behavioral biology. Part A: [Original articles] on p. 110-116

Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory.

Janine Kwapis, Y Alaghband, E Kramár, A López, A Vogel Ciernia, A White, G Shu, D Rhee, C Michael, E Montellier, Y Liu, C Magnan, Shu-Jen Chen, P Sassone-Corsi, P Baldi, D Matheos, M Wood, 2018, Nature Communications on p. 3323