Janine Kwapis

Assistant Professor of Biology

Janine Kwapis

Research Summary

Molecular and epigenetic mechanisms underlying learning and memory and age-related memory impairments.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Memory Fear Genes Conditioning (Psychology) Learning Anxiety Long Term Memory Amygdala Brain Data Storage Equipment Circadian Clocks Hippocampus Conditioning Calcium Calmodulin Dependent Protein Kinase Type 2 Phosphorylation Proteasome Endopeptidase Complex Prefrontal Cortex Epigenomics Proteolysis Maintenance Psychological Extinction Neuronal Plasticity Animals Rodentia Proteins

Most Recent Publications

Time to learn: The role of the molecular circadian clock in learning and memory

Chad W. Smies, Kasuni K. Bodinayake, Janine L. Kwapis, 2022, Communications in behavioral biology. Part A: [Original articles]

The circadian clock gene Per1 modulates context fear memory formation within the retrosplenial cortex in a sex-specific manner

Mark W. Urban, Chenyu Lo, Kasuni K. Bodinayake, Chad A. Brunswick, Shoko Murakami, Ashley C. Heimann, Janine L. Kwapis, 2021, Communications in behavioral biology. Part A: [Original articles]

Contributions of the rodent cingulate-retrosplenial cortical axis to associative learning and memory: A proposed circuit for persistent memory maintenance

Sydney Trask, Nicole C. Ferrara, Aaron M. Jasnow, Janine L. Kwapis, 2021, Neuroscience and Biobehavioral Reviews on p. 178-184

Special issue “molecular mechanisms of memory formation and modification”

Timothy J. Jarome, Janine L. Kwapis, 2021, International Journal of Molecular Sciences

Molecular mechanisms of reconsolidation-dependent memory updating

Lauren Bellfy, Janine L. Kwapis, 2020, International Journal of Molecular Sciences on p. 1-18

Investigating Memory Updating in Mice Using the Objects in Updated Locations Task

Destiny S. Wright, Kasuni K. Bodinayake, Janine L. Kwapis, 2020, Current Protocols in Neuroscience

A neuroscientist's guide to transgenic mice and other genetic tools

Shaghayegh Navabpour, Janine L. Kwapis, Timothy J. Jarome, 2020, Neuroscience and Biobehavioral Reviews on p. 732-748

Aging mice show impaired memory updating in the novel OUL updating paradigm

Janine L. Kwapis, Yasaman Alaghband, Ashley A. Keiser, Tri N. Dong, Christina M. Michael, Diane Rhee, Guanhua Shu, Richard T. Dang, Dina P. Matheos, Marcelo A. Wood, 2020, Neuropsychopharmacology on p. 337-346

GluR2 endocytosis-dependent protein degradation in the amygdala mediates memory updating

Nicole C. Ferrara, Timothy J. Jarome, Patrick K. Cullen, Sabrina A. Orsi, Janine L. Kwapis, Sydney Trask, Shane E. Pullins, Fred J. Helmstetter, 2019, Scientific Reports on p. 5180

Exercise opens a temporal window for enhanced cognitive improvement from subsequent physical activity

Christopher W. Butler, Ashley A. Keiser, Janine L. Kwapis, Nicole C. Berchtold, Vanessa L. Wall, Marcelo A. Wood, Carl W. Cotman, 2019, Learning and Memory on p. 485-492

Most-Cited Papers

CaMKII regulates proteasome phosphorylation and activity and promotes memory destabilization following retrieval

Timothy J. Jarome, Nicole C. Ferrara, Janine L. Kwapis, Fred J. Helmstetter, 2016, Communications in behavioral biology. Part A: [Original articles] on p. 103-109

Trace and contextual fear conditioning are impaired following unilateral microinjection of muscimol in the ventral hippocampus or amygdala, but not the medial prefrontal cortex

Marieke R. Gilmartin, Janine L. Kwapis, Fred J. Helmstetter, 2012, Communications in behavioral biology. Part A: [Original articles] on p. 452-464

CaMKII, but not protein kinase A, regulates Rpt6 phosphorylation and proteasome activity during the formation of long-term memories

Timothy J. Jarome, Janine L. Kwapis, Wendy L. Ruenzel, Fred J. Helmstetter, 2013, Frontiers in Behavioral Neuroscience

Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory

Janine L. Kwapis, Yasaman Alaghband, Enikö A. Kramár, Alberto J. López, Annie Vogel Ciernia, André O. White, Guanhua Shu, Diane Rhee, Christina M. Michael, Emilie Montellier, Yu Liu, Christophe N. Magnan, Siwei Chen, Paolo Sassone-Corsi, Pierre Baldi, Dina P. Matheos, Marcelo A. Wood, 2018, Nature Communications on p. 3323

The retrosplenial cortex is involved in the formation of memory for context and trace fear conditioning

Janine L. Kwapis, Timothy J. Jarome, Jonathan L. Lee, Fred J. Helmstetter, 2015, Communications in behavioral biology. Part A: [Original articles] on p. 110-116

Epigenetic mechanisms in fear conditioning: Implications for treating post-traumatic stress disorder

Janine L. Kwapis, Marcelo A. Wood, 2014, Trends in Neurosciences on p. 706-720

Promoter-specific effects of DREADD modulation on hippocampal synaptic plasticity and memory formation

Alberto J. López, Enikö Kramár, Dina P. Matheos, André O. White, Janine Kwapis, Annie Vogel-Ciernia, Keith Sakata, Monica Espinoza, Marcelo A. Wood, 2016, Journal of Neuroscience on p. 3588-3599

NR2A- and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioning

Marieke R. Gilmartin, Janine L. Kwapis, Fred J. Helmstetter, 2013, Learning and Memory on p. 290-294

Does PKM(zeta) maintain memory?

Janine L. Kwapis, Fred J. Helmstetter, 2014, Journal of Electrophysiological Techniques on p. 36-45

Extinguishing trace fear engages the retrosplenial cortex rather than the amygdala

Janine L. Kwapis, Timothy J. Jarome, Jonathan L. Lee, Marieke R. Gilmartin, Fred J. Helmstetter, 2014, Communications in behavioral biology. Part A: [Original articles] on p. 41-54