Janine Kwapis
Assistant Professor of Biology

-
516 Mueller Lab
University Park, PA - She/Her
- jlk855@psu.edu
Research Summary
Molecular and epigenetic mechanisms underlying learning and memory and age-related memory impairments.
Huck Graduate Students
Huck Affiliations
- Molecular, Cellular, and Integrative Biosciences
- Neuroscience
- Center for Molecular Investigation of Neurological Disorders
- Center for Brain, Behavior, and Cognition
- Neuroscience Institute
Links
Publication Tags
Memory Genes Fear Data Storage Equipment Learning Conditioning (Psychology) Long Term Memory Brain Anxiety Circadian Clocks Amygdala Epigenomics Neuronal Plasticity Calcium Calmodulin Dependent Protein Kinase Type 2 Phosphorylation Brain Derived Neurotrophic Factor Plastic Property Cocaine Proteasome Endopeptidase Complex Long Term Potentiation Transgenic Mice Hippocampus Proteolysis Maintenance Psychological ExtinctionMost Recent Publications
Time to learn: The role of the molecular circadian clock in learning and memory
Chad W. Smies, Kasuni K. Bodinayake, Janine L. Kwapis, 2022, Communications in behavioral biology. Part A: [Original articles]
The clock gene Per1 expression may exert diurnal control over hippocampal memory consolidation
Lauren Bellfy, Chad Smies, Alicia Bernhardt, Kasuni Bodinayake, Aswathy Sebastian, Emily Stuart, Chen-Yu Lo, Shoko Murakami, Hannah Boyd, Megan von Abo, Istvan Albert, Janine Kwapis, 2022, BioRxiv
Contributions of the rodent cingulate-retrosplenial cortical axis to associative learning and memory: A proposed circuit for persistent memory maintenance
Sydney Trask, Nicole C. Ferrara, Aaron M. Jasnow, Janine L. Kwapis, 2021, Neuroscience and Biobehavioral Reviews on p. 178-184
The circadian clock gene Per1 modulates context fear memory formation within the retrosplenial cortex in a sex-specific manner
Mark W. Urban, Chenyu Lo, Kasuni K. Bodinayake, Chad A. Brunswick, Shoko Murakami, Ashley C. Heimann, Janine L. Kwapis, 2021, Communications in behavioral biology. Part A: [Original articles]
Special issue “molecular mechanisms of memory formation and modification”
Timothy J. Jarome, Janine L. Kwapis, 2021, International Journal of Molecular Sciences
Molecular mechanisms of reconsolidation-dependent memory updating
Lauren Bellfy, Janine L. Kwapis, 2020, International Journal of Molecular Sciences on p. 1-18
Investigating Memory Updating in Mice Using the Objects in Updated Locations Task
Destiny S. Wright, Kasuni K. Bodinayake, Janine L. Kwapis, 2020, Current Protocols in Neuroscience
A neuroscientist's guide to transgenic mice and other genetic tools
Shaghayegh Navabpour, Janine L. Kwapis, Timothy J. Jarome, 2020, Neuroscience and Biobehavioral Reviews on p. 732-748
Aging mice show impaired memory updating in the novel OUL updating paradigm
Janine L. Kwapis, Yasaman Alaghband, Ashley A. Keiser, Tri N. Dong, Christina M. Michael, Diane Rhee, Guanhua Shu, Richard T. Dang, Dina P. Matheos, Marcelo A. Wood, 2020, Neuropsychopharmacology on p. 337-346
GluR2 endocytosis-dependent protein degradation in the amygdala mediates memory updating
Nicole C. Ferrara, Timothy J. Jarome, Patrick K. Cullen, Sabrina A. Orsi, Janine L. Kwapis, Sydney Trask, Shane E. Pullins, Fred J. Helmstetter, 2019, Scientific Reports on p. 5180
Most-Cited Papers
CaMKII regulates proteasome phosphorylation and activity and promotes memory destabilization following retrieval
Timothy J. Jarome, Nicole C. Ferrara, Janine L. Kwapis, Fred J. Helmstetter, 2016, Communications in behavioral biology. Part A: [Original articles] on p. 103-109
CaMKII, but not protein kinase A, regulates Rpt6 phosphorylation and proteasome activity during the formation of long-term memories
Timothy J. Jarome, Janine L. Kwapis, Wendy L. Ruenzel, Fred J. Helmstetter, 2013, Frontiers in Behavioral Neuroscience
Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory
Janine L. Kwapis, Yasaman Alaghband, Enikö A. Kramár, Alberto J. López, Annie Vogel Ciernia, André O. White, Guanhua Shu, Diane Rhee, Christina M. Michael, Emilie Montellier, Yu Liu, Christophe N. Magnan, Siwei Chen, Paolo Sassone-Corsi, Pierre Baldi, Dina P. Matheos, Marcelo A. Wood, 2018, Nature Communications on p. 3323
Epigenetic mechanisms in fear conditioning: Implications for treating post-traumatic stress disorder
Janine L. Kwapis, Marcelo A. Wood, 2014, Trends in Neurosciences on p. 706-720
The retrosplenial cortex is involved in the formation of memory for context and trace fear conditioning
Janine L. Kwapis, Timothy J. Jarome, Jonathan L. Lee, Fred J. Helmstetter, 2015, Communications in behavioral biology. Part A: [Original articles] on p. 110-116
Promoter-specific effects of DREADD modulation on hippocampal synaptic plasticity and memory formation
Alberto J. López, Enikö Kramár, Dina P. Matheos, André O. White, Janine Kwapis, Annie Vogel-Ciernia, Keith Sakata, Monica Espinoza, Marcelo A. Wood, 2016, Journal of Neuroscience on p. 3588-3599
NR2A- and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioning
Marieke R. Gilmartin, Janine L. Kwapis, Fred J. Helmstetter, 2013, Learning and Memory on p. 290-294
Does PKM(zeta) maintain memory?
Janine L. Kwapis, Fred J. Helmstetter, 2014, Journal of Electrophysiological Techniques on p. 36-45
Extinguishing trace fear engages the retrosplenial cortex rather than the amygdala
Janine L. Kwapis, Timothy J. Jarome, Jonathan L. Lee, Marieke R. Gilmartin, Fred J. Helmstetter, 2014, Communications in behavioral biology. Part A: [Original articles] on p. 41-54
BDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens
André O. White, Enikö A. Kramár, Alberto J. López, Janine L. Kwapis, John Doan, David Saldana, M. Felicia Davatolhagh, Yasaman Alaghband, Mathew Blurton-Jones, Dina P. Matheos, Marcelo A. Wood, 2016, Nature Communications on p. 11725