Janine Kwapis

Assistant Professor of Biology

Janine Kwapis

Research Summary

Molecular and epigenetic mechanisms underlying learning and memory and age-related memory impairments.

Huck Graduate Students

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Publication Tags

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Memory Genes Fear Learning Conditioning (Psychology) Long Term Memory Brain Data Storage Equipment Circadian Clocks Calcium Calmodulin Dependent Protein Kinase Type 2 Anxiety Epigenomics Phosphorylation Proteasome Endopeptidase Complex Hippocampus Amygdala Maintenance Neuronal Plasticity Animals Proteins Time Conditioning Rodentia Plastic Property Prefrontal Cortex

Most Recent Publications

The clock gene Per1 is necessary in the retrosplenial cortex—but not in the suprachiasmatic nucleus—for incidental learning in young and aging male mice

Chad A. Brunswick, Derek J. Baldwin, Kasuni K. Bodinayake, Alexandria R. McKenna, Chen Yu Lo, Lauren Bellfy, Mark W. Urban, Emily M. Stuart, Shoko Murakami, Chad W. Smies, Janine L. Kwapis, 2023, Neurobiology of Aging on p. 77-90

The clock gene Per1 may exert diurnal control over hippocampal memory consolidation

Lauren Bellfy, Chad W. Smies, Alicia R. Bernhardt, Kasuni K. Bodinayake, Aswathy Sebastian, Emily M. Stuart, Destiny S. Wright, Chen Yu Lo, Shoko Murakami, Hannah M. Boyd, Megan J. von Abo, Istvan Albert, Janine L. Kwapis, 2023, Neuropsychopharmacology

Memory retrieval, reconsolidation, and extinction: Exploring the boundary conditions of post-conditioning cue exposure

Nicole C. Ferrara, Janine L. Kwapis, Sydney Trask, 2023, Frontiers in Synaptic Neuroscience

Connecting the Dots: Potential Interactions Between Sex Hormones and the Circadian System During Memory Consolidation

Hannah M. Boyd, Karyn M. Frick, Janine L. Kwapis, 2023, Journal of Biological Rhythms

Time to learn: The role of the molecular circadian clock in learning and memory

Chad W. Smies, Kasuni K. Bodinayake, Janine L. Kwapis, 2022, Communications in behavioral biology. Part A: [Original articles]

Contributions of the rodent cingulate-retrosplenial cortical axis to associative learning and memory: A proposed circuit for persistent memory maintenance

Sydney Trask, Nicole C. Ferrara, Aaron M. Jasnow, Janine L. Kwapis, 2021, Neuroscience and Biobehavioral Reviews on p. 178-184

The circadian clock gene Per1 modulates context fear memory formation within the retrosplenial cortex in a sex-specific manner

Mark W. Urban, Chenyu Lo, Kasuni K. Bodinayake, Chad A. Brunswick, Shoko Murakami, Ashley C. Heimann, Janine L. Kwapis, 2021, Communications in behavioral biology. Part A: [Original articles]

Special issue “molecular mechanisms of memory formation and modification”

Timothy J. Jarome, Janine L. Kwapis, 2021, International Journal of Molecular Sciences

Molecular mechanisms of reconsolidation-dependent memory updating

Lauren Bellfy, Janine L. Kwapis, 2020, International Journal of Molecular Sciences on p. 1-18

Investigating Memory Updating in Mice Using the Objects in Updated Locations Task

Destiny S. Wright, Kasuni K. Bodinayake, Janine L. Kwapis, 2020, Current Protocols in Neuroscience

Most-Cited Papers

CaMKII regulates proteasome phosphorylation and activity and promotes memory destabilization following retrieval

Timothy J. Jarome, Nicole C. Ferrara, Janine L. Kwapis, Fred J. Helmstetter, 2016, Communications in behavioral biology. Part A: [Original articles] on p. 103-109

Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory

Janine L. Kwapis, Yasaman Alaghband, Enikö A. Kramár, Alberto J. López, Annie Vogel Ciernia, André O. White, Guanhua Shu, Diane Rhee, Christina M. Michael, Emilie Montellier, Yu Liu, Christophe N. Magnan, Siwei Chen, Paolo Sassone-Corsi, Pierre Baldi, Dina P. Matheos, Marcelo A. Wood, 2018, Nature Communications on p. 3323

CaMKII, but not protein kinase A, regulates Rpt6 phosphorylation and proteasome activity during the formation of long-term memories

Timothy J. Jarome, Janine L. Kwapis, Wendy L. Ruenzel, Fred J. Helmstetter, 2013, Frontiers in Behavioral Neuroscience

Epigenetic mechanisms in fear conditioning: Implications for treating post-traumatic stress disorder

Janine L. Kwapis, Marcelo A. Wood, 2014, Trends in Neurosciences on p. 706-720

The retrosplenial cortex is involved in the formation of memory for context and trace fear conditioning

Janine L. Kwapis, Timothy J. Jarome, Jonathan L. Lee, Fred J. Helmstetter, 2015, Communications in behavioral biology. Part A: [Original articles] on p. 110-116

Promoter-specific effects of DREADD modulation on hippocampal synaptic plasticity and memory formation

Alberto J. López, Enikö Kramár, Dina P. Matheos, André O. White, Janine Kwapis, Annie Vogel-Ciernia, Keith Sakata, Monica Espinoza, Marcelo A. Wood, 2016, Journal of Neuroscience on p. 3588-3599

NR2A- and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioning

Marieke R. Gilmartin, Janine L. Kwapis, Fred J. Helmstetter, 2013, Learning and Memory on p. 290-294

A neuroscientist's guide to transgenic mice and other genetic tools

Shaghayegh Navabpour, Janine L. Kwapis, Timothy J. Jarome, 2020, Neuroscience and Biobehavioral Reviews on p. 732-748

Context and Auditory Fear are Differentially Regulated by HDAC3 Activity in the Lateral and Basal Subnuclei of the Amygdala

Janine L. Kwapis, Yasaman Alaghband, Alberto J. López, André O. White, Rianne R. Campbell, Richard T. Dang, DIane Rhee, Ashley V. Tran, Allison E. Carl, DIna P. Matheos, Marcelo A. Wood, 2017, Neuropsychopharmacology on p. 1284-1294

Does PKM(zeta) maintain memory?

Janine L. Kwapis, Fred J. Helmstetter, 2014, Journal of Electrophysiological Techniques on p. 36-45