Janine Kwapis
Assistant Professor of Biology

-
516 Mueller Lab
University Park, PA - She/Her
- jlk855@psu.edu
Research Summary
Molecular and epigenetic mechanisms underlying learning and memory and age-related memory impairments.
Huck Graduate Students
Huck Affiliations
- Molecular, Cellular, and Integrative Biosciences
- Neuroscience
- Center for Molecular Investigation of Neurological Disorders
- Center for Brain, Behavior, and Cognition
- Neuroscience Institute
Links
Publication Tags
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Memory Genes Fear Learning Conditioning (Psychology) Long Term Memory Brain Data Storage Equipment Circadian Clocks Calcium Calmodulin Dependent Protein Kinase Type 2 Anxiety Epigenomics Phosphorylation Proteasome Endopeptidase Complex Hippocampus Amygdala Maintenance Neuronal Plasticity Animals Proteins Time Conditioning Rodentia Plastic Property Prefrontal CortexMost Recent Publications
The clock gene Per1 is necessary in the retrosplenial cortex—but not in the suprachiasmatic nucleus—for incidental learning in young and aging male mice
Chad A. Brunswick, Derek J. Baldwin, Kasuni K. Bodinayake, Alexandria R. McKenna, Chen Yu Lo, Lauren Bellfy, Mark W. Urban, Emily M. Stuart, Shoko Murakami, Chad W. Smies, Janine L. Kwapis, 2023, Neurobiology of Aging on p. 77-90
The clock gene Per1 may exert diurnal control over hippocampal memory consolidation
Lauren Bellfy, Chad W. Smies, Alicia R. Bernhardt, Kasuni K. Bodinayake, Aswathy Sebastian, Emily M. Stuart, Destiny S. Wright, Chen Yu Lo, Shoko Murakami, Hannah M. Boyd, Megan J. von Abo, Istvan Albert, Janine L. Kwapis, 2023, Neuropsychopharmacology
Memory retrieval, reconsolidation, and extinction: Exploring the boundary conditions of post-conditioning cue exposure
Nicole C. Ferrara, Janine L. Kwapis, Sydney Trask, 2023, Frontiers in Synaptic Neuroscience
Connecting the Dots: Potential Interactions Between Sex Hormones and the Circadian System During Memory Consolidation
Hannah M. Boyd, Karyn M. Frick, Janine L. Kwapis, 2023, Journal of Biological Rhythms
Time to learn: The role of the molecular circadian clock in learning and memory
Chad W. Smies, Kasuni K. Bodinayake, Janine L. Kwapis, 2022, Communications in behavioral biology. Part A: [Original articles]
Contributions of the rodent cingulate-retrosplenial cortical axis to associative learning and memory: A proposed circuit for persistent memory maintenance
Sydney Trask, Nicole C. Ferrara, Aaron M. Jasnow, Janine L. Kwapis, 2021, Neuroscience and Biobehavioral Reviews on p. 178-184
The circadian clock gene Per1 modulates context fear memory formation within the retrosplenial cortex in a sex-specific manner
Mark W. Urban, Chenyu Lo, Kasuni K. Bodinayake, Chad A. Brunswick, Shoko Murakami, Ashley C. Heimann, Janine L. Kwapis, 2021, Communications in behavioral biology. Part A: [Original articles]
Special issue “molecular mechanisms of memory formation and modification”
Timothy J. Jarome, Janine L. Kwapis, 2021, International Journal of Molecular Sciences
Molecular mechanisms of reconsolidation-dependent memory updating
Lauren Bellfy, Janine L. Kwapis, 2020, International Journal of Molecular Sciences on p. 1-18
Investigating Memory Updating in Mice Using the Objects in Updated Locations Task
Destiny S. Wright, Kasuni K. Bodinayake, Janine L. Kwapis, 2020, Current Protocols in Neuroscience
Most-Cited Papers
CaMKII regulates proteasome phosphorylation and activity and promotes memory destabilization following retrieval
Timothy J. Jarome, Nicole C. Ferrara, Janine L. Kwapis, Fred J. Helmstetter, 2016, Communications in behavioral biology. Part A: [Original articles] on p. 103-109
Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory
Janine L. Kwapis, Yasaman Alaghband, Enikö A. Kramár, Alberto J. López, Annie Vogel Ciernia, André O. White, Guanhua Shu, Diane Rhee, Christina M. Michael, Emilie Montellier, Yu Liu, Christophe N. Magnan, Siwei Chen, Paolo Sassone-Corsi, Pierre Baldi, Dina P. Matheos, Marcelo A. Wood, 2018, Nature Communications on p. 3323
CaMKII, but not protein kinase A, regulates Rpt6 phosphorylation and proteasome activity during the formation of long-term memories
Timothy J. Jarome, Janine L. Kwapis, Wendy L. Ruenzel, Fred J. Helmstetter, 2013, Frontiers in Behavioral Neuroscience
Epigenetic mechanisms in fear conditioning: Implications for treating post-traumatic stress disorder
Janine L. Kwapis, Marcelo A. Wood, 2014, Trends in Neurosciences on p. 706-720
The retrosplenial cortex is involved in the formation of memory for context and trace fear conditioning
Janine L. Kwapis, Timothy J. Jarome, Jonathan L. Lee, Fred J. Helmstetter, 2015, Communications in behavioral biology. Part A: [Original articles] on p. 110-116
Promoter-specific effects of DREADD modulation on hippocampal synaptic plasticity and memory formation
Alberto J. López, Enikö Kramár, Dina P. Matheos, André O. White, Janine Kwapis, Annie Vogel-Ciernia, Keith Sakata, Monica Espinoza, Marcelo A. Wood, 2016, Journal of Neuroscience on p. 3588-3599
NR2A- and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioning
Marieke R. Gilmartin, Janine L. Kwapis, Fred J. Helmstetter, 2013, Learning and Memory on p. 290-294
A neuroscientist's guide to transgenic mice and other genetic tools
Shaghayegh Navabpour, Janine L. Kwapis, Timothy J. Jarome, 2020, Neuroscience and Biobehavioral Reviews on p. 732-748
Context and Auditory Fear are Differentially Regulated by HDAC3 Activity in the Lateral and Basal Subnuclei of the Amygdala
Janine L. Kwapis, Yasaman Alaghband, Alberto J. López, André O. White, Rianne R. Campbell, Richard T. Dang, DIane Rhee, Ashley V. Tran, Allison E. Carl, DIna P. Matheos, Marcelo A. Wood, 2017, Neuropsychopharmacology on p. 1284-1294
Does PKM(zeta) maintain memory?
Janine L. Kwapis, Fred J. Helmstetter, 2014, Journal of Electrophysiological Techniques on p. 36-45