Janine Kwapis

Assistant Professor of Biology

Janine Kwapis

Research Summary

Molecular and epigenetic mechanisms underlying learning and memory and age-related memory impairments.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Memory Genes Fear Data Storage Equipment Learning Conditioning (Psychology) Long Term Memory Brain Anxiety Circadian Clocks Amygdala Epigenomics Neuronal Plasticity Calcium Calmodulin Dependent Protein Kinase Type 2 Phosphorylation Brain Derived Neurotrophic Factor Plastic Property Cocaine Proteasome Endopeptidase Complex Long Term Potentiation Transgenic Mice Hippocampus Proteolysis Maintenance Psychological Extinction

Most Recent Publications

Time to learn: The role of the molecular circadian clock in learning and memory

Chad W. Smies, Kasuni K. Bodinayake, Janine L. Kwapis, 2022, Communications in behavioral biology. Part A: [Original articles]

The clock gene Per1 expression may exert diurnal control over hippocampal memory consolidation

Lauren Bellfy, Chad Smies, Alicia Bernhardt, Kasuni Bodinayake, Aswathy Sebastian, Emily Stuart, Chen-Yu Lo, Shoko Murakami, Hannah Boyd, Megan von Abo, Istvan Albert, Janine Kwapis, 2022, BioRxiv

Contributions of the rodent cingulate-retrosplenial cortical axis to associative learning and memory: A proposed circuit for persistent memory maintenance

Sydney Trask, Nicole C. Ferrara, Aaron M. Jasnow, Janine L. Kwapis, 2021, Neuroscience and Biobehavioral Reviews on p. 178-184

The circadian clock gene Per1 modulates context fear memory formation within the retrosplenial cortex in a sex-specific manner

Mark W. Urban, Chenyu Lo, Kasuni K. Bodinayake, Chad A. Brunswick, Shoko Murakami, Ashley C. Heimann, Janine L. Kwapis, 2021, Communications in behavioral biology. Part A: [Original articles]

Special issue “molecular mechanisms of memory formation and modification”

Timothy J. Jarome, Janine L. Kwapis, 2021, International Journal of Molecular Sciences

Molecular mechanisms of reconsolidation-dependent memory updating

Lauren Bellfy, Janine L. Kwapis, 2020, International Journal of Molecular Sciences on p. 1-18

Investigating Memory Updating in Mice Using the Objects in Updated Locations Task

Destiny S. Wright, Kasuni K. Bodinayake, Janine L. Kwapis, 2020, Current Protocols in Neuroscience

A neuroscientist's guide to transgenic mice and other genetic tools

Shaghayegh Navabpour, Janine L. Kwapis, Timothy J. Jarome, 2020, Neuroscience and Biobehavioral Reviews on p. 732-748

Aging mice show impaired memory updating in the novel OUL updating paradigm

Janine L. Kwapis, Yasaman Alaghband, Ashley A. Keiser, Tri N. Dong, Christina M. Michael, Diane Rhee, Guanhua Shu, Richard T. Dang, Dina P. Matheos, Marcelo A. Wood, 2020, Neuropsychopharmacology on p. 337-346

GluR2 endocytosis-dependent protein degradation in the amygdala mediates memory updating

Nicole C. Ferrara, Timothy J. Jarome, Patrick K. Cullen, Sabrina A. Orsi, Janine L. Kwapis, Sydney Trask, Shane E. Pullins, Fred J. Helmstetter, 2019, Scientific Reports on p. 5180

Most-Cited Papers

CaMKII regulates proteasome phosphorylation and activity and promotes memory destabilization following retrieval

Timothy J. Jarome, Nicole C. Ferrara, Janine L. Kwapis, Fred J. Helmstetter, 2016, Communications in behavioral biology. Part A: [Original articles] on p. 103-109

CaMKII, but not protein kinase A, regulates Rpt6 phosphorylation and proteasome activity during the formation of long-term memories

Timothy J. Jarome, Janine L. Kwapis, Wendy L. Ruenzel, Fred J. Helmstetter, 2013, Frontiers in Behavioral Neuroscience

Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory

Janine L. Kwapis, Yasaman Alaghband, Enikö A. Kramár, Alberto J. López, Annie Vogel Ciernia, André O. White, Guanhua Shu, Diane Rhee, Christina M. Michael, Emilie Montellier, Yu Liu, Christophe N. Magnan, Siwei Chen, Paolo Sassone-Corsi, Pierre Baldi, Dina P. Matheos, Marcelo A. Wood, 2018, Nature Communications on p. 3323

Epigenetic mechanisms in fear conditioning: Implications for treating post-traumatic stress disorder

Janine L. Kwapis, Marcelo A. Wood, 2014, Trends in Neurosciences on p. 706-720

The retrosplenial cortex is involved in the formation of memory for context and trace fear conditioning

Janine L. Kwapis, Timothy J. Jarome, Jonathan L. Lee, Fred J. Helmstetter, 2015, Communications in behavioral biology. Part A: [Original articles] on p. 110-116

Promoter-specific effects of DREADD modulation on hippocampal synaptic plasticity and memory formation

Alberto J. López, Enikö Kramár, Dina P. Matheos, André O. White, Janine Kwapis, Annie Vogel-Ciernia, Keith Sakata, Monica Espinoza, Marcelo A. Wood, 2016, Journal of Neuroscience on p. 3588-3599

NR2A- and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioning

Marieke R. Gilmartin, Janine L. Kwapis, Fred J. Helmstetter, 2013, Learning and Memory on p. 290-294

Does PKM(zeta) maintain memory?

Janine L. Kwapis, Fred J. Helmstetter, 2014, Journal of Electrophysiological Techniques on p. 36-45

Extinguishing trace fear engages the retrosplenial cortex rather than the amygdala

Janine L. Kwapis, Timothy J. Jarome, Jonathan L. Lee, Marieke R. Gilmartin, Fred J. Helmstetter, 2014, Communications in behavioral biology. Part A: [Original articles] on p. 41-54

BDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens

André O. White, Enikö A. Kramár, Alberto J. López, Janine L. Kwapis, John Doan, David Saldana, M. Felicia Davatolhagh, Yasaman Alaghband, Mathew Blurton-Jones, Dina P. Matheos, Marcelo A. Wood, 2016, Nature Communications on p. 11725