James Connor

Distinguished Professor and Vice Chair of Neurosurgery

James Connor

Research Summary

Iron transport and toxicity in neurodegenerative diseases/oxidative cell injury.

Huck Affiliations

Links

Most Recent Publications

Linking genetics to MRI-DTI: HFE polymorphism delays Alzheimer's disease white matter degeneration in APOE4 carriers

James Connor, 2025, Journal of Alzheimer’s Disease

A Common Mutation in the Homeostatic Iron Regulatory Gene Alters Astrocyte Migration and Redox Profile

James Connor, 2025, FASEB BioAdvances

What Does Iron Mean to an Oligodendrocyte?

James Connor, 2025, Glia

Analysis of transition metal content in glioblastoma reveals association between iron and survival

Ganesh Shenoy, Aurosman Sahu, Madison Kuhn, Vladimir Khristov, Madison Heebner, Hannah Wilding, Taylor Clegg, Debarati Bhanja, Quinn Wade, Laura Jean Liermann, Dongxiang Wang, Nataliya Smith, Gabriela Remite-Berthet, Chachrit Khunsriraksakul, Kondaiah Palsa, Becky Slagle-Webb, Seyed Alireza Mansouri, Brad E. Zacharia, Elizabeth A. Proctor, James Connor, 2025, Translational Oncology

A common variant in the iron regulatory gene (Hfe) alters the metabolic and transcriptional landscape in brain regions vulnerable to neurodegeneration

Savannah Marshall Moscon, Elizabeth Neely, Elizabeth Anne Proctor, James Connor, 2024, Journal of Neurochemistry on p. 3132-3153

Iron Deficiency and Sleep/Wake Behaviors: A Scoping Review of Clinical Practice Guidelines—How to Overcome the Current Conundrum?

Scout McWilliams, Olivia Hill, Osman S. Ipsiroglu, Stefan Clemens, Alexander Mark Weber, Michael Chen, James Connor, Barbara T. Felt, Mauro Manconi, Andre Mattman, Rosalia Silvestri, Narong Simakajornboon, Susan M. Smith, Sylvia Stockler, 2024, Nutrients

Neurobehavioral deficits, histoarchitectural alterations, parvalbumin neuronal damage and glial activation in the brain of male Wistar rat exposed to Landfill leachate

Usende Ifukibot Levi, Mofio M. Bintu, Osinachi Chinonyerem Daniella, Oyelowo Abdulraheem Fatima Oyenike, Adikpe Oluwa Agbonu, Azeez Mariam Adedamola, Enefe Ndidi, Sanni Fatimah Saka, Beselia V. Gela, Smart I. Mbagwu, Edem Ekpenyong Edem, Olopade James Olukayode, Connor James, 2024, Journal of Chemical Neuroanatomy

Oral iron therapy: Current concepts and future prospects for improving efficacy and outcomes

Pearl O. Ebea-Ugwuanyi, Sadasivan Vidyasagar, James R. Connor, David M. Frazer, Mitchell D. Knutson, James F. Collins, 2024, British Journal of Haematology on p. 759-773

HFE Mutations in Neurodegenerative Disease as a Model of Hormesis

Savannah L. Marshall Moscon, James R. Connor, 2024, International Journal of Molecular Sciences

Analysis of anemia and iron supplementation among glioblastoma patients reveals sex-biased association between anemia and survival

G Shenoy, B Slagle-Webb, C Khunsriraksakul, B Pandya Shesh, J Luo, V Khristov, N Smith, Alireza Mansouri, Brad Zacharia, S Holder, J Lathia, J Barnholtz-Sloan, James Connor, 2024, Scientific Reports on p. 2389

Most-Cited Papers

Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells

David L. Schonberg, Tyler E. Miller, Qiulian Wu, William A. Flavahan, Nupur K. Das, James S. Hale, Christopher G. Hubert, Stephen C. Mack, Awad M. Jarrar, Robert T. Karl, Ann Mari Rosager, Anne M. Nixon, Paul J. Tesar, Petra Hamerlik, Bjarne W. Kristensen, Craig Horbinski, James Connor, Paul L. Fox, Justin D. Lathia, Jeremy N. Rich, 2015, Cancer Cell on p. 441-455

Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report

Richard P. Allen, Daniel L. Picchietti, Michael Auerbach, Yong Won Cho, James R. Connor, Christopher J. Earley, Diego Garcia-Borreguero, Suresh Kotagal, Mauro Manconi, William Ondo, Jan Ulfberg, John W. Winkelman, 2018, Sleep Medicine on p. 27-44

Iron, Myelin, and the Brain: Neuroimaging Meets Neurobiology

Harald E. Möller, Lucia Bossoni, James R. Connor, Robert R. Crichton, Mark D. Does, Roberta J. Ward, Luigi Zecca, Fabio A. Zucca, Itamar Ronen, 2019, Trends in Neurosciences on p. 384-401

Quantitative susceptibility mapping of the midbrain in Parkinson's disease

Guangwei Du, T Liu, Mechelle M. Lewis, Lan Kong, Y Wang, James Connor, Richard B. Mailman, Xuemei Huang, 2016, Movement Disorders on p. 317-324

Iron uptake and transport across physiological barriers

Kari A. Duck, James R. Connor, 2016, BioMetals on p. 573-591

The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin

Douglas G. Peters, James R. Connor, Mark D. Meadowcroft, 2015, Neurobiology of Disease on p. 49-65

Sex differences in cancer incidence and survival: a pan-cancer analysis

Michelle Dong, Gino Cioffi, Jacqueline Wang, Kristin A. Waite, Quinn T. Ostrom, Carol Kruchko, Justin D. Lathia, Joshua B. Rubin, Michael E. Berens, James Connor, Jill S. Barnholtz-Sloan, 2020, Cancer Epidemiology Biomarkers and Prevention on p. 1389-1397

The Management of Restless Legs Syndrome: An Updated Algorithm

Michael H. Silber, Mark J. Buchfuhrer, Christopher J. Earley, Brian B. Koo, Mauro Manconi, John W. Winkelman, Phillip Becker, J. Andrew Berkowski, Stefan Clemens, James R. Connor, Sergi Ferré, Jennifer G. Hensley, Byron C. Jones, Elias G. Karroum, Brian Koo, William Ondo, Kathy Richards, Denise Sharon, Lynn Marie Trotti, George Uhl, Arthur S. Walters, 2021, Mayo Clinic Proceedings on p. 1921-1937

A novel model for brain iron uptake: Introducing the concept of regulation

Ian A. Simpson, Padmavathi Ponnuru, Marianne E. Klinger, Roland L. Myers, Kavi Devraj, Christopher L. Coe, Gabriele R. Lubach, Anthony Carruthers, James R. Connor, 2015, Journal of Cerebral Blood Flow and Metabolism on p. 48-57

Iron and restless legs syndrome: treatment, genetics and pathophysiology

James R. Connor, Stephanie M. Patton, Konrad Oexle, Richard P. Allen, 2017, Sleep Medicine on p. 61-70