James Connor
Distinguished Professor and Vice Chair of Neurosurgery

-
H110 Neurosurgery
Hershey, PA 17033 - jrc3@psu.edu
- 717-531-4541
Research Summary
Iron transport and toxicity in neurodegenerative diseases/oxidative cell injury.
Huck Affiliations
Links
Publication Tags
Iron Neoplasms Glioblastoma Brain Therapeutics Parkinson Disease Fullerenes Ferritins Transferrin Survival Restless Legs Syndrome Substantia Nigra Biomarkers Liquid Biopsy Medical Nanotechnology Proteins Cerebrospinal Fluid Homeostasis Carcinogenesis Macrophages Magnetic Resonance Imaging Alzheimer Disease Inflammation Apoferritins DioxygenMost Recent Publications
Regulation of brain iron uptake by apo- and holo-transferrin is dependent on sex and delivery protein
Stephanie L. Baringer, Elizabeth B. Neely, Kondaiah Palsa, Ian A. Simpson, James R. Connor, 2022, Fluids and Barriers of the CNS
Plasma IL13Rα2 as a novel liquid biopsy biomarker for glioblastoma
Vladimir Khristov, Darya Nesterova, Mara Trifoi, Taylor Clegg, Annika Daya, Thomas Barrett, Emily Tufano, Ganesh Shenoy, Bhavyata Pandya, Gela Beselia, Nataliya Smith, Oliver Mrowczynski, Brad Zacharia, Kristin Waite, Justin Lathia, Jill Barnholtz-Sloan, James Connor, 2022, Journal of Neuro-Oncology on p. 743-752
Neuropharmacological Study of Posaconazole for Glioblastoma: A Phase 0 Clinical Trial Protocol
Debarati Bhanja, Jeffrey Neighbors, James Connor, Gelareh Zadeh, Seyed Alireza Mansouri, 2022, Neurosurgery on p. 658-665
Importance of the intersection of age and sex to understand variation in incidence and survival for primary malignant gliomas
Gi Ming Wang, Gino Cioffi, Nirav Patil, Kristin A. Waite, Robert Lanese, Quinn T. Ostrom, Carol Kruchko, Michael E. Berens, James R. Connor, Justin D. Lathia, Joshua B. Rubin, Jill S. Barnholtz-Sloan, 2022, Neuro-Oncology on p. 302-310
Dynamics of Nigral Iron Accumulation in Parkinson's Disease: From Diagnosis to Late Stage
Guangwei Du, Ernest Wang, Christopher Sica, Hairong Chen, Sol De Jesus, Mechelle Lewis, Lan Kong, James Connor, Richard B. Mailman, Xuemei Huang, 2022, Movement Disorders on p. 1654-1662
Tumor-Derived Biomarkers in Liquid Biopsy of Glioblastoma
Vladimir Khristov, Andrea Lin, Zachary Freedman, Jacob Staub, Ganesh Shenoy, Oliver Mrowczynski, Elias Rizk, Brad Zacharia, James Connor, 2022, World Neurosurgery
Low plasma serotonin linked to higher nigral iron in Parkinson’s disease
L Jellen, Mechelle M. Lewis, Guangwei Du, X Wang, Galvis MLE, Martha L.Escobar Galvis, S Krzyzanowski, C Capan, A Snyder, James R. Connor, Lan Kong, Richard B. Mailman, P Brundin, L Brundin, Xuemei Huang, 2021, Scientific Reports on p. 24384
Independently validated sex-specific nomograms for predicting survival in patients with newly diagnosed glioblastoma: NRG Oncology RTOG 0525 and 0825
N Patil, E Somasundaram, K Waite, J Lathia, M Machtay, M Gilbert, James Connor, J Rubin, M Berens, R Buerki, S Choi, A Sloan, M Penas-Prado, L Ashby, D Blumenthal, M Werner-Wasik, G Hunter, J Flickinger, M Wendland, V Panet-Raymond, H Robins, S Pugh, M Mehta, J Barnholtz-Sloan, 2021, Journal of Neuro-Oncology on p. 363-372
Nutritional Yeast Ferritin Iron Complex: A Novel Source of Dietary Iron
James Connor, Unger Erica, R Keil, J Flanagan, S Patton, Gabriele Lubach, Martin Schafer, Christopher Coe, 2021, Nutritional Yeast Ferritin Iron Complex: A Novel Source of Dietary Iron on p. 122-131
Higher CSF Ferritin Heavy-Chain (Fth1) and Transferrin Predict Better Neurocognitive Performance in People with HIV
Harpreet Kaur, William S. Bush, Scott L. Letendre, Ronald J. Ellis, Robert K. Heaton, Stephanie M. Patton, James R. Connor, David C. Samuels, Donald R. Franklin, Todd Hulgan, Asha R. Kallianpur, 2021, Molecular Neurobiology on p. 4842-4855
Most-Cited Papers
Altered Brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease)
Christopher J. Earley, James Connor, Diego Garcia-Borreguero, Peter Jenner, John Winkelman, Phyllis C. Zee, Richard Allen, 2014, Sleep Medicine on p. 1288-1301
Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells
David L. Schonberg, Tyler E. Miller, Qiulian Wu, William A. Flavahan, Nupur K. Das, James S. Hale, Christopher G. Hubert, Stephen C. Mack, Awad M. Jarrar, Robert T. Karl, Ann Mari Rosager, Anne M. Nixon, Paul J. Tesar, Petra Hamerlik, Bjarne W. Kristensen, Craig Horbinski, James Connor, Paul L. Fox, Justin D. Lathia, Jeremy N. Rich, 2015, Cancer Cell on p. 441-455
The significance of ferritin in cancer: Anti-oxidation, inflammation and tumorigenesis
Ahmed A. Alkhateeb, James Connor, 2013, Biochimica et Biophysica Acta - Reviews on Cancer on p. 245-254
Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report
Richard P. Allen, Daniel L. Picchietti, Michael Auerbach, Yong Won Cho, James R. Connor, Christopher J. Earley, Diego Garcia-Borreguero, Suresh Kotagal, Mauro Manconi, William Ondo, Jan Ulfberg, John W. Winkelman, 2018, Sleep Medicine on p. 27-44
Application of fullerenes in nanomedicine: An update
Anthony Dellinger, Zhiguo Zhou, James Connor, Ab Madhankumar, Sarala Pamujula, Christie M. Sayes, Christopher L. Kepley, 2013, Nanomedicine on p. 1191-1208
Quantitative susceptibility mapping of the midbrain in Parkinson's disease
Guangwei Du, Tian Liu, Mechelle M. Lewis, Lan Kong, Yi Wang, James Connor, Richard B. Mailman, Xuemei Huang, 2016, Movement Disorders on p. 317-324
Ferritin stimulates breast cancer cells through an iron-independent mechanism and is localized within tumor-associated macrophages
Ahmed A. Alkhateeb, Bing Han, James Connor, 2013, Breast Cancer Research and Treatment on p. 733-744
The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin
Douglas G. Peters, James R. Connor, Mark D. Meadowcroft, 2015, Neurobiology of Disease on p. 49-65
A novel model for brain iron uptake: Introducing the concept of regulation
Ian A. Simpson, Padmavathi Ponnuru, Marianne E. Klinger, Roland L. Myers, Kavi Devraj, Christopher L. Coe, Gabriele R. Lubach, Anthony Carruthers, James R. Connor, 2015, Journal of Cerebral Blood Flow and Metabolism on p. 48-57
Iron uptake and transport across physiological barriers
Kari A. Duck, James R. Connor, 2016, BioMetals on p. 573-591