James Connor

Distinguished Professor and Vice Chair of Neurosurgery

James Connor

Research Summary

Iron transport and toxicity in neurodegenerative diseases/oxidative cell injury.

Huck Affiliations


Publication Tags

Iron Brain Apoferritins Neoplasms Transferrin Small Interfering Rna Therapeutics Survival Oxidative Stress Amyloid Heterografts Glioblastoma Oligodendroglia Neurilemmoma Cells Cerebrospinal Fluid Radiation Proteins Neurodegenerative Diseases Alzheimer Disease Caspase 3 Ferritins Biomarkers Endothelial Cells Parkinson Disease

Most Recent Papers

Endothelial cells are critical regulators of iron transport in a model of the human blood–brain barrier

Brian Chiou, Emma H. Neal, Aaron B. Bowman, Ethan S. Lippmann, Ian A. Simpson, James R. Connor, 2019, Journal of Cerebral Blood Flow and Metabolism on p. 2117-2131

Cerebrospinal Fluid Ceruloplasmin, Haptoglobin, and Vascular Endothelial Growth Factor Are Associated with Neurocognitive Impairment in Adults with HIV Infection

A. R. Kallianpur, H. Gittleman, S. Letendre, R. Ellis, J. S. Barnholtz-Sloan, W. S. Bush, R. Heaton, D. C. Samuels, D. R. Franklin, D. Rosario-Cookson, D. B. Clifford, A. C. Collier, B. Gelman, C. M. Marra, J. C. McArthur, J. A. McCutchan, S. Morgello, I. Grant, D. Simpson, James Connor, T. Hulgan, 2019, Molecular Neurobiology on p. 3808-3818

Semaphorin4A causes loss of mature oligodendrocytes and demyelination in vivo

Brian Chiou, Elizabeth Neely, Asha Kallianpur, James Connor, 2019, Journal of Neuroinflammation

MLN8237 treatment in an orthoxenograft murine model for malignant peripheral nerve sheath tumors

Russell Payne, Oliver D. Mrowczynski, Becky Slagle-Webb, Alexandre Bourcier, Christine Mau, Dawit Aregawi, Achuthamangalam B. Madhankumar, Sang Y. Lee, Kimberly Harbaugh, James Connor, Elias B. Rizk, 2019, Journal of neurosurgery on p. 465-475

Transferrin and H-ferritin involvement in brain iron acquisition during postnatal development

Brian Chiou, Elizabeth B. Neely, Dillon S. Mcdevitt, Ian Simpson, James Connor, 2019, Journal of neurochemistry

Oroxylum indicum (L.) extract protects human neuroblastoma SH-SY5Y cells against ß-amyloid-induced cell injury

Nootchanat Mairuae, James R. Connor, Benjaporn Buranrat, Sang Y. Lee, 2019, Molecular medicine reports on p. 1933-1942

Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms

Vagisha Ravi, Achuthamangalam B. Madhankumar, Thomas Abraham, Becky Slagle-Webb, James R. Connor, 2019, PloS one

Targeting IL-13Ra<sub>2</sub> for effective treatment of malignant peripheral nerve sheath tumors in mouse models

Oliver D. Mrowczynski, Russell A. Payne, Alexandre J. Bourcier, Christine Y. Mau, Becky Slagle-Webb, Ganesh Shenoy, Achuthamangalam B. Madhankumar, Stephan B. Abramson, Darren Wolfe, Kimberly S. Harbaugh, Elias B. Rizk, James R. Connor, 2019, Journal of neurosurgery on p. 1369-1379

Exosomes impact survival to radiation exposure in cell line models of nervous system cancer

Oliver D. Mrowczynski, Achuthamangalam Madhankumar, Jeffrey Sundstrom, Yuanjun Zhao, Yuka Imamura, Becky Slagle-Webb, Christine Mau, Russell A. Payne, Elias Rizk, Brad Zacharia, James Connor, 2018, Oncotarget on p. 36083-36101

Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients

Guangwei Du, Mechelle Lewis, Christopher Sica, Lu He, James Connor, Lan Kong, Richard Mailman, Xuemei Huang, 2018, Movement Disorders on p. 1423-1431

Most-Cited Papers

Profile of altered brain iron acquisition in restless legs syndrome

James R. Connor, Padmavathi Ponnuru, Xin Sheng Wang, Stephanie M. Patton, Richard P. Allen, Christopher J. Earley, 2011, Brain on p. 959-968

Olfactory deficit detected by fMRI in early Alzheimer's disease

Jianli Wang, Paul J. Eslinger, Richard L. Doty, Erin K. Zimmerman, Robert Grunfeld, Xiaoyu Sun, Mark D. Meadowcroft, James R. Connor, Joseph L. Price, Michael B. Smith, Qing X. Yang, 2010, Brain research on p. 184-194

Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells

David L. Schonberg, Tyler E. Miller, Qiulian Wu, William A. Flavahan, Nupur K. Das, James S. Hale, Christopher G. Hubert, Stephen C. Mack, Awad M. Jarrar, Robert T. Karl, Ann Mari Rosager, Anne M. Nixon, Paul J. Tesar, Petra Hamerlik, Bjarne W. Kristensen, Craig Horbinski, James Connor, Paul L. Fox, Justin D. Lathia, Jeremy N. Rich, 2015, Cancer Cell on p. 441-455

HFE gene variants affect iron in the brain

Wint Nandar, James R. Connor, 2011, Journal of Nutrition on p. 729S-739S

Quantitative susceptibility mapping of the midbrain in Parkinson's disease

Guangwei Du, Tian Liu, Mechelle M. Lewis, Lan Kong, Yi Wang, James Connor, Richard B. Mailman, Xuemei Huang, 2016, Movement Disorders on p. 317-324

H-ferritin is the major source of iron for oligodendrocytes

Bozho Todorich, Xuesheng Zhang, James R. Connor, 2011, Glia on p. 927-935

Plasma biomarkers associated with ALS and their relationship to iron homeostasis

Ryan M. Mitchell, Zachary Simmons, John L. Beard, Helen E. Stephens, James R. Connor, 2010, Muscle and Nerve on p. 95-103

A novel model for brain iron uptake

Ian A. Simpson, Padmavathi Ponnuru, Marianne E. Klinger, Roland L. Myers, Kavi Devraj, Christopher L. Coe, Gabriele R. Lubach, Anthony Carruthers, James R. Connor, 2015, Journal of Cerebral Blood Flow and Metabolism on p. 48-57

Ferritin stimulates breast cancer cells through an iron-independent mechanism and is localized within tumor-associated macrophages

Ahmed A. Alkhateeb, Bing Han, James Connor, 2013, Breast Cancer Research and Treatment on p. 733-744

Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice

Majda Hadziahmetovic, Ying Song, Padmavathi Ponnuru, Jared Iacovelli, Allan Hunter, Nadine Haddad, John Beard, James R. Connor, Sophie Vaulont, Joshua L. Dunaief, 2011, Investigative Ophthalmology and Visual Science on p. 109-118