James Connor

Distinguished Professor and Vice Chair of Neurosurgery

James Connor

Research Summary

Iron transport and toxicity in neurodegenerative diseases/oxidative cell injury.

Huck Affiliations


Publication Tags

Iron Brain Therapeutics Nanoparticles Restless Legs Syndrome Neoplasms Transferrin Toxicity Glioblastoma Fullerenes Paraquat Tumors Genes Genotype Oxidative Stress Parkinson Disease Synucleins Interleukin 13 Medical Nanotechnology T Cells Astrocytes Chimeric Antigen Receptors Stem Cells In Vitro Techniques Ferritins

Most Recent Papers

HFE H63D Limits Nigral Vulnerability to Paraquat in Agricultural Workers

Ernest W. Wang, Max L. Trojano, Mechelle M. Lewis, Guangwei Du, Hairong Chen, Gregory L. Brown, Leslie C. Jellen, Insung Song, Elizabeth Neely, Lan Kong, James R. Connor, Xuemei Huang, 2021, Toxicological Sciences on p. 47-57

A potential role for zinc in restless legs syndrome

Pan Chen, Julia Bornhorst, Stephanie Patton, Kanika Bagai, Rachana Nitin, Mahfuzur Miah, Dominic J. Hare, Kai Kysenius, Peter J. Crouch, Lan Xiong, Guy A. Rouleau, Tanja Schwerdtle, James Connor, Michael Aschner, Aaron B. Bowman, Arthur S. Walters, 2021, Sleep

Biological activity of a thiobarbituric acid compound in neuroblastomas

Sang Lee, Becky Slagle-Webb, Arun K. Sharma, James R. Connor, 2021, Anticancer Research on p. 1171-1181

Tumor Targeted Delivery of an Anti-Cancer Therapeutic

You Jung Kang, Claire K. Holley, Mohammad Reza Abidian, Achuthamangalam B. Madhankumar, James Connor, Sheereen Majd, 2021, Advanced healthcare materials

JAM-A functions as a female microglial tumor suppressor in glioblastoma

Soumya M. Turaga, Daniel J. Silver, Defne Bayik, Evi Paouri, Sen Peng, Adam Lauko, Tyler J. Alban, Nozha Borjini, Sarah Stanko, Ulhas P. Naik, Ruth A. Keri, James R. Connor, Jill S. Barnholtz-Sloan, Joshua B. Rubin, Michael Berens, Dimitrios Davalos, Justin D. Lathia, 2020, Neuro-Oncology on p. 1591-1601

Characterization of a novel barbituric acid and two thiobarbituric acid compounds for lung cancer treatment

Sang Lee, Becky Slagle-Webb, Arun Sharma, James R. Connor, 2020, Anticancer Research on p. 6039-6049

The roles of iron and HFE genotype in neurological diseases

Yunsung Kim, James R. Connor, 2020, Molecular Aspects of Medicine

High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma

Gloria B. Kim, Virginia Aragon-Sanabria, Lauren Randolph, Hali Jiang, Joshua A. Reynolds, Becky S. Webb, Achuthamangalam Madhankumar, Xiaojun Lian, James R. Connor, Jian Yang, Cheng Dong, 2020, Bioactive Materials on p. 624-635

H63D variant of the homeostatic iron regulator (HFE) gene alters α-synuclein expression, aggregation, and toxicity

Yunsung Kim, Mark C. Stahl, Xuemei Huang, James R. Connor, 2020, Journal of Neurochemistry on p. 177-190

The Nrf2-mediated defense mechanism associated with HFE genotype limits vulnerability to oxidative stress-induced toxicity

Insung Y. Song, Amanda M. Snyder, Yunsung Kim, Elizabeth B. Neely, Quinn W. Wade, James R. Connor, 2020, Toxicology

Most-Cited Papers

Altered Brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease)

Christopher J. Earley, James Connor, Diego Garcia-Borreguero, Peter Jenner, John Winkelman, Phyllis C. Zee, Richard Allen, 2014, Sleep Medicine on p. 1288-1301

Profile of altered brain iron acquisition in restless legs syndrome

James R. Connor, Padmavathi Ponnuru, Xin Sheng Wang, Stephanie M. Patton, Richard P. Allen, Christopher J. Earley, 2011, Brain on p. 959-968

The significance of ferritin in cancer

Ahmed A. Alkhateeb, James Connor, 2013, Biochimica et Biophysica Acta - Reviews on Cancer on p. 245-254

Preferential iron trafficking characterizes glioblastoma stem-like cells

David L. Schonberg, Tyler E. Miller, Qiulian Wu, William A. Flavahan, Nupur K. Das, James S. Hale, Christopher G. Hubert, Stephen C. Mack, Awad M. Jarrar, Robert T. Karl, Ann Mari Rosager, Anne M. Nixon, Paul J. Tesar, Petra Hamerlik, Bjarne W. Kristensen, Craig Horbinski, James Connor, Paul L. Fox, Justin D. Lathia, Jeremy N. Rich, 2015, Cancer Cell on p. 441-455

Application of fullerenes in nanomedicine

Anthony Dellinger, Zhiguo Zhou, James Connor, Ab Madhankumar, Sarala Pamujula, Christie M. Sayes, Christopher L. Kepley, 2013, Nanomedicine on p. 1191-1208

Quantitative susceptibility mapping of the midbrain in Parkinson's disease

Guangwei Du, Tian Liu, Mechelle M. Lewis, Lan Kong, Yi Wang, James Connor, Richard B. Mailman, Xuemei Huang, 2016, Movement Disorders on p. 317-324

Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children

Richard P. Allen, Daniel L. Picchietti, Michael Auerbach, Yong Won Cho, James R. Connor, Christopher J. Earley, Diego Garcia-Borreguero, Suresh Kotagal, Mauro Manconi, William Ondo, Jan Ulfberg, John W. Winkelman, 2018, Sleep Medicine on p. 27-44

Functional roles of transferrin in the brain

Dominique F. Leitner, James R. Connor, 2012, Biochimica et Biophysica Acta - General Subjects on p. 393-402

HFE gene variants affect iron in the brain

Wint Nandar, James R. Connor, 2011, Journal of Nutrition on p. 729S-739S

H-ferritin is the major source of iron for oligodendrocytes

Bozho Todorich, Xuesheng Zhang, James R. Connor, 2011, GLIA on p. 927-935