James Connor
Distinguished Professor and Vice Chair of Neurosurgery
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H110 Neurosurgery
Hershey, PA 17033 - jrc3@psu.edu
- 717-531-4541
Research Summary
Iron transport and toxicity in neurodegenerative diseases/oxidative cell injury.
Huck Affiliations
Links
Publication Tags
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Iron Brain Neoplasms Fullerenes Glioblastoma Ferritins Therapeutics Parkinson Disease Restless Legs Syndrome Medical Nanotechnology Transferrin Proteins Homeostasis Survival Endothelial Cells Carcinogenesis Biomarkers Substantia Nigra Macrophages Alzheimer Disease Magnetic Resonance Imaging Clinical Trial Protocols Dioxygen Application ExosomesMost Recent Publications
A novel view of ferritin in cancer.
B Shesh, James Connor, 2023, Biochimica et biophysica acta. Reviews on cancer on p. 188917
Brain iron acquisition: An overview of homeostatic regulation and disease dysregulation.
S Baringer, I Simpson, James Connor, 2023, Journal of neurochemistry
Exosomes are involved in iron transport from human blood–brain barrier endothelial cells and are modified by endothelial cell iron status
Kondaiah Palsa, Stephanie L. Baringer, Ganesh Shenoy, Vladimir S. Spiegelman, Ian A. Simpson, James Connor, 2023, Journal of Biological Chemistry
H- ferritin in sows' colostrum and milk-derived extracellular vesicles: a novel iron delivery concept.
Kondaiah Palsa, James Connor, J Flanagan, Elizabeth Hines, 2023, Journal of animal science
Apo- and holo- transferrin differentially interact with ferroportin and hephaestin to regulate iron release at the blood-brain barrier.
S Baringer, K Palsa, I Simpson, James Connor, 2023, bioRxiv : the preprint server for biology
Plasma IL13Rα2 as a novel liquid biopsy biomarker for glioblastoma
Vladimir Khristov, Darya Nesterova, Mara Trifoi, Taylor Clegg, Annika Daya, Thomas Barrett, Emily Tufano, Ganesh Shenoy, Bhavyata Pandya, Gela Beselia, Nataliya Smith, Oliver Mrowczynski, Brad Zacharia, Kristin Waite, Justin Lathia, Jill Barnholtz-Sloan, James Connor, 2022, Journal of Neuro-Oncology on p. 743-752
Regulation of brain iron uptake by apo- and holo-transferrin is dependent on sex and delivery protein
Stephanie L. Baringer, Elizabeth B. Neely, Kondaiah Palsa, Ian A. Simpson, James R. Connor, 2022, Fluids and Barriers of the CNS
Neuropharmacological Study of Posaconazole for Glioblastoma: A Phase 0 Clinical Trial Protocol
Debarati Bhanja, Jeffrey Neighbors, James Connor, Gelareh Zadeh, Seyed Alireza Mansouri, 2022, Neurosurgery on p. 658-665
Importance of the intersection of age and sex to understand variation in incidence and survival for primary malignant gliomas
Gi Ming Wang, Gino Cioffi, Nirav Patil, Kristin A. Waite, Robert Lanese, Quinn T. Ostrom, Carol Kruchko, Michael E. Berens, James R. Connor, Justin D. Lathia, Joshua B. Rubin, Jill S. Barnholtz-Sloan, 2022, Neuro-Oncology on p. 302-310
Dynamics of Nigral Iron Accumulation in Parkinson's Disease: From Diagnosis to Late Stage
Guangwei Du, Ernest Wang, Christopher Sica, Hairong Chen, Sol De Jesus, De Jesus, Sol, Mechelle Lewis, Lan Kong, James Connor, Richard B. Mailman, Xuemei Huang, 2022, Movement Disorders on p. 1654-1662
Most-Cited Papers
Altered Brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease)
Christopher J. Earley, James Connor, Diego Garcia-Borreguero, Peter Jenner, John Winkelman, Phyllis C. Zee, Richard Allen, 2014, Sleep Medicine on p. 1288-1301
Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells
David L. Schonberg, Tyler E. Miller, Qiulian Wu, William A. Flavahan, Nupur K. Das, James S. Hale, Christopher G. Hubert, Stephen C. Mack, Awad M. Jarrar, Robert T. Karl, Ann Mari Rosager, Anne M. Nixon, Paul J. Tesar, Petra Hamerlik, Bjarne W. Kristensen, Craig Horbinski, James Connor, Paul L. Fox, Justin D. Lathia, Jeremy N. Rich, 2015, Cancer Cell on p. 441-455
The significance of ferritin in cancer: Anti-oxidation, inflammation and tumorigenesis
Ahmed A. Alkhateeb, James Connor, 2013, Biochimica et Biophysica Acta - Reviews on Cancer on p. 245-254
Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report
Richard P. Allen, Daniel L. Picchietti, Michael Auerbach, Yong Won Cho, James R. Connor, Christopher J. Earley, Diego Garcia-Borreguero, Suresh Kotagal, Mauro Manconi, William Ondo, Jan Ulfberg, John W. Winkelman, 2018, Sleep Medicine on p. 27-44
Application of fullerenes in nanomedicine: An update
Anthony Dellinger, Zhiguo Zhou, James Connor, Ab Madhankumar, Sarala Pamujula, Christie M. Sayes, Christopher L. Kepley, 2013, Nanomedicine on p. 1191-1208
Quantitative susceptibility mapping of the midbrain in Parkinson's disease
Guangwei Du, T Liu, Mechelle M. Lewis, Lan Kong, Y Wang, James Connor, Richard B. Mailman, Xuemei Huang, 2016, Movement Disorders on p. 317-324
The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin
Douglas G. Peters, James R. Connor, Mark D. Meadowcroft, 2015, Neurobiology of Disease on p. 49-65
Iron uptake and transport across physiological barriers
Kari A. Duck, James R. Connor, 2016, BioMetals on p. 573-591
Ferritin stimulates breast cancer cells through an iron-independent mechanism and is localized within tumor-associated macrophages
Ahmed A. Alkhateeb, Bing Han, James Connor, 2013, Breast Cancer Research and Treatment on p. 733-744
A novel model for brain iron uptake: Introducing the concept of regulation
Ian A. Simpson, Padmavathi Ponnuru, Marianne E. Klinger, Roland L. Myers, Kavi Devraj, Christopher L. Coe, Gabriele R. Lubach, Anthony Carruthers, James R. Connor, 2015, Journal of Cerebral Blood Flow and Metabolism on p. 48-57