James Connor

Distinguished Professor and Vice Chair of Neurosurgery

James Connor

Research Summary

Iron transport and toxicity in neurodegenerative diseases/oxidative cell injury.

Huck Affiliations

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Publication Tags

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Iron Brain Restless Legs Syndrome Therapeutics Glioblastoma Stem Cells Neoplasms Homeostasis Myelin Sheath Neuroimaging Alzheimer Disease Parkinson Disease Mesencephalon Toxic Sex Characteristics Apoferritins Practice Guidelines Energy Incidence Uptake Mechanisms Neurotransmitter Neoplastic Stem Cells Pharmacological Metabolism Neurobiology Advisory Committees

Most Recent Publications

Analysis of anemia and iron supplementation among glioblastoma patients reveals sex-biased association between anemia and survival

Ganesh Shenoy, Becky Slagle-Webb, Chachrit Khunsriraksakul, Bhavyata Pandya Shesh, Jingqin Luo, Vladimir Khristov, Nataliya Smith, Alireza Mansouri, Brad E. Zacharia, Sheldon Holder, Justin D. Lathia, Jill S. Barnholtz-Sloan, James R. Connor, 2024, Scientific Reports

Neurobehavioral deficits, histoarchitectural alterations, parvalbumin neuronal damage and glial activation in the brain of male Wistar rat exposed to Landfill leachate

Usende Ifukibot Levi, Mofio M. Bintu, Osinachi Chinonyerem Daniella, Oyelowo Abdulraheem Fatima Oyenike, Adikpe Oluwa Agbonu, Azeez Mariam Adedamola, Enefe Ndidi, Sanni Fatimah Saka, Beselia V. Gela, Smart I. Mbagwu, Edem Ekpenyong Edem, Olopade James Olukayode, Connor James, 2024, Journal of Chemical Neuroanatomy

Oral iron therapy: Current concepts and future prospects for improving efficacy and outcomes

Pearl O. Ebea-Ugwuanyi, Sadasivan Vidyasagar, James R. Connor, David M. Frazer, Mitchell D. Knutson, James F. Collins, 2024, British Journal of Haematology on p. 759-773

Homeostatic iron regulatory protein drives glioblastoma growth via tumor cell-intrinsic and sex-specific responses

Katie M. Troike, Sabrina Z. Wang, Daniel J. Silver, Juyeun Lee, Erin E. Mulkearns-Hubert, Nicole Hajdari, Prabar K. Ghosh, Kristen E. Kay, Julia L. Beilis, Sofia E. Mitchell, Christopher W. Bishop, Ellen S. Hong, Mykyta Artomov, Christopher G. Hubert, Prajwal Rajappa, James R. Connor, Paul L. Fox, Bjarne W. Kristensen, Justin D. Lathia, 2024, Neuro-Oncology Advances

Brain iron acquisition depends on age and sex in iron-deficient mice

Kondaiah Palsa, Elizabeth B. Neely, Stephanie L. Baringer, Timothy B. Helmuth, Ian A. Simpson, James R. Connor, 2024, FASEB Journal

Iron inhibits glioblastoma cell migration and polarization

Ganesh Shenoy, Sina Kheirabadi, Zaman Ataie, Aurosman Pappus Sahu, Kondaiah Palsa, Quinn Wade, Chachrit Khunsriraksakul, Vladimir Khristov, Becky Slagle-Webb, Justin D. Lathia, Hong Gang Wang, Amir Sheikhi, James R. Connor, 2023, FASEB Journal

A closer look at the role of iron in glioblastoma

Ganesh Shenoy, James R. Connor, 2023, Neuro-Oncology on p. 2136-2149

Common Mutation in the HFE Gene Modifies Recovery After Intracerebral Hemorrhage

Timothy B. Helmuth, Rashmi Kumari, Kondaiah Palsa, Elizabeth B. Neely, Becky Slagle-Webb, Scott D. Simon, James R. Connor, 2023, Stroke on p. 2886-2894

Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood–brain barrier by altering the ratio of apo- and holo-transferrin

Stephanie L. Baringer, Avraham S. Lukacher, Kondaiah Palsa, Hyosung Kim, Ethan S. Lippmann, Vladimir S. Spiegelman, Ian A. Simpson, James R. Connor, 2023, Journal of Neurochemistry on p. 248-261

Uptake of H-ferritin by Glioblastoma stem cells and its impact on their invasion capacity

Bhavyata Pandya Shesh, Becky Slagle-Webb, Ganesh Shenoy, Vladimir Khristov, Brad E. Zacharia, James R. Connor, 2023, Journal of Cancer Research and Clinical Oncology on p. 9691-9703

Most-Cited Papers

Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells

David L. Schonberg, Tyler E. Miller, Qiulian Wu, William A. Flavahan, Nupur K. Das, James S. Hale, Christopher G. Hubert, Stephen C. Mack, Awad M. Jarrar, Robert T. Karl, Ann Mari Rosager, Anne M. Nixon, Paul J. Tesar, Petra Hamerlik, Bjarne W. Kristensen, Craig Horbinski, James Connor, Paul L. Fox, Justin D. Lathia, Jeremy N. Rich, 2015, Cancer Cell on p. 441-455

Altered Brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease)

Christopher J. Earley, James Connor, Diego Garcia-Borreguero, Peter Jenner, John Winkelman, Phyllis C. Zee, Richard Allen, 2014, Sleep Medicine on p. 1288-1301

Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report

Richard P. Allen, Daniel L. Picchietti, Michael Auerbach, Yong Won Cho, James R. Connor, Christopher J. Earley, Diego Garcia-Borreguero, Suresh Kotagal, Mauro Manconi, William Ondo, Jan Ulfberg, John W. Winkelman, 2018, Sleep Medicine on p. 27-44

Quantitative susceptibility mapping of the midbrain in Parkinson's disease

Guangwei Du, T Liu, Mechelle M. Lewis, Lan Kong, Y Wang, James Connor, Richard B. Mailman, Xuemei Huang, 2016, Movement Disorders on p. 317-324

The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin

Douglas G. Peters, James R. Connor, Mark D. Meadowcroft, 2015, Neurobiology of Disease on p. 49-65

Iron uptake and transport across physiological barriers

Kari A. Duck, James R. Connor, 2016, BioMetals on p. 573-591

Iron, Myelin, and the Brain: Neuroimaging Meets Neurobiology

Harald E. Möller, Lucia Bossoni, James R. Connor, Robert R. Crichton, Mark D. Does, Roberta J. Ward, Luigi Zecca, Fabio A. Zucca, Itamar Ronen, 2019, Trends in Neurosciences on p. 384-401

A novel model for brain iron uptake: Introducing the concept of regulation

Ian A. Simpson, Padmavathi Ponnuru, Marianne E. Klinger, Roland L. Myers, Kavi Devraj, Christopher L. Coe, Gabriele R. Lubach, Anthony Carruthers, James R. Connor, 2015, Journal of Cerebral Blood Flow and Metabolism on p. 48-57

Iron and restless legs syndrome: treatment, genetics and pathophysiology

James R. Connor, Stephanie M. Patton, Konrad Oexle, Richard P. Allen, 2017, Sleep Medicine on p. 61-70

Sex differences in cancer incidence and survival: a pan-cancer analysis

Michelle Dong, Gino Cioffi, Jacqueline Wang, Kristin A. Waite, Quinn T. Ostrom, Carol Kruchko, Justin D. Lathia, Joshua B. Rubin, Michael E. Berens, James Connor, Jill S. Barnholtz-Sloan, 2020, Cancer Epidemiology Biomarkers and Prevention on p. 1389-1397