James Connor

Distinguished Professor and Vice Chair of Neurosurgery

James Connor

Research Summary

Iron transport and toxicity in neurodegenerative diseases/oxidative cell injury.

Huck Affiliations


Publication Tags

Iron Brain Neoplasms Genes Glioblastoma Apoferritins Nanoparticles Transferrin Therapeutics Survival Genotype Oxidative Stress Toxicity Restless Legs Syndrome Astrocytes T Cells Lung Neoplasms Chimeric Antigen Receptors Synucleins Interleukin 13 Ferritins Parkinson Disease Sex Characteristics Endothelial Cells Blood Brain Barrier

Most Recent Papers

JAM-A functions as a female microglial tumor suppressor in glioblastoma

Soumya M. Turaga, Daniel J. Silver, Defne Bayik, Evi Paouri, Sen Peng, Adam Lauko, Tyler J. Alban, Nozha Borjini, Sarah Stanko, Ulhas P. Naik, Ruth A. Keri, James R. Connor, Jill S. Barnholtz-Sloan, Joshua B. Rubin, Michael Berens, Dimitrios Davalos, Justin D. Lathia, 2020, Neuro-Oncology on p. 1591-1601

High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma

Gloria B. Kim, Virginia Aragon-Sanabria, Lauren Randolph, Hali Jiang, Joshua A. Reynolds, Becky S. Webb, Achuthamangalam Madhankumar, Xiaojun Lian, James R. Connor, Jian Yang, Cheng Dong, 2020, Bioactive Materials on p. 624-635

H63D variant of the homeostatic iron regulator (HFE) gene alters α-synuclein expression, aggregation, and toxicity

Yunsung Kim, Mark C. Stahl, Xuemei Huang, James R. Connor, 2020, Journal of Neurochemistry on p. 177-190

The Nrf2-mediated defense mechanism associated with HFE genotype limits vulnerability to oxidative stress-induced toxicity

Insung Y. Song, Amanda M. Snyder, Yunsung Kim, Elizabeth B. Neely, Quinn W. Wade, James R. Connor, 2020, Toxicology

Sex differences in cancer incidence and survival: a pan-cancer analysis

Michelle Dong, Gino Cioffi, Jacqueline Wang, Kristin A. Waite, Quinn T. Ostrom, Carol Kruchko, Justin D. Lathia, Joshua B. Rubin, Michael E. Berens, James Connor, Jill S. Barnholtz-Sloan, 2020, Cancer Epidemiology Biomarkers and Prevention on p. 1389-1397

Evidence for communication of peripheral iron status to cerebrospinal fluid: clinical implications for therapeutic strategy

James R. Connor, Kari Duck, Stephanie Patton, Ian A. Simpson, Lynn Marie Trotti, Richard Allen, Christopher J. Earley, David Rye, 2020, Fluids and Barriers of the CNS

Transferrin and H-ferritin involvement in brain iron acquisition during postnatal development: impact of sex and genotype

Brian Chiou, Elizabeth B. Neely, Dillon S. Mcdevitt, Ian A. Simpson, James R. Connor, 2020, Journal of Neurochemistry on p. 381-396

Impact of HFE variants and sex in lung cancer

Sang Y. Lee, Vonn Walter, Junjia Zhu, Anna C. Salzberg, Dajiang J. Liu, James R. Connor, 2019, PLoS One

Sex is an important prognostic factor for glioblastoma but not for nonglioblastoma

Haley Gittleman, Quinn T. Ostrom, L. C. Stetson, Kristin Waite, Tiffany R. Hodges, Christina H. Wright, James Wright, Joshua B. Rubin, Michael E. Berens, Justin Lathia, James R. Connor, Carol Kruchko, Andrew E. Sloan, Jill S. Barnholtz-Sloan, 2019, Neuro-Oncology Practice on p. 451-462

Endothelial cells are critical regulators of iron transport in a model of the human blood–brain barrier

Brian Chiou, Emma H. Neal, Aaron B. Bowman, Ethan S. Lippmann, Ian A. Simpson, James R. Connor, 2019, Journal of Cerebral Blood Flow and Metabolism on p. 2117-2131

Most-Cited Papers

Profile of altered brain iron acquisition in restless legs syndrome

James R. Connor, Padmavathi Ponnuru, Xin Sheng Wang, Stephanie M. Patton, Richard P. Allen, Christopher J. Earley, 2011, Brain on p. 959-968

Preferential iron trafficking characterizes glioblastoma stem-like cells

David L. Schonberg, Tyler E. Miller, Qiulian Wu, William A. Flavahan, Nupur K. Das, James S. Hale, Christopher G. Hubert, Stephen C. Mack, Awad M. Jarrar, Robert T. Karl, Ann Mari Rosager, Anne M. Nixon, Paul J. Tesar, Petra Hamerlik, Bjarne W. Kristensen, Craig Horbinski, James Connor, Paul L. Fox, Justin D. Lathia, Jeremy N. Rich, 2015, Cancer Cell on p. 441-455

Quantitative susceptibility mapping of the midbrain in Parkinson's disease

Guangwei Du, Tian Liu, Mechelle M. Lewis, Lan Kong, Yi Wang, James Connor, Richard B. Mailman, Xuemei Huang, 2016, Movement Disorders on p. 317-324

HFE gene variants affect iron in the brain

Wint Nandar, James R. Connor, 2011, Journal of Nutrition on p. 729S-739S

Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children

Richard P. Allen, Daniel L. Picchietti, Michael Auerbach, Yong Won Cho, James R. Connor, Christopher J. Earley, Diego Garcia-Borreguero, Suresh Kotagal, Mauro Manconi, William Ondo, Jan Ulfberg, John W. Winkelman, 2018, Sleep Medicine on p. 27-44

H-ferritin is the major source of iron for oligodendrocytes

Bozho Todorich, Xuesheng Zhang, James R. Connor, 2011, GLIA on p. 927-935

A novel model for brain iron uptake: introducing the concept of regulation

Ian A. Simpson, Padmavathi Ponnuru, Marianne E. Klinger, Roland L. Myers, Kavi Devraj, Christopher L. Coe, Gabriele R. Lubach, Anthony Carruthers, James R. Connor, 2015, Journal of Cerebral Blood Flow and Metabolism on p. 48-57

Ferritin stimulates breast cancer cells through an iron-independent mechanism and is localized within tumor-associated macrophages

Ahmed A. Alkhateeb, Bing Han, James Connor, 2013, Breast Cancer Research and Treatment on p. 733-744

Gender and iron genes may modify associations between brain iron and memory in healthy aging

George Bartzokis, Po H. Lu, Kathleen Tingus, Douglas G. Peters, Chetan P. Amar, Todd A. Tishler, J. Paul Finn, Pablo Villablanca, Lori L. Altshuler, Jim Mintz, Elizabeth Neely, James R. Connor, 2011, Neuropsychopharmacology on p. 1375-1384

Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice

Majda Hadziahmetovic, Ying Song, Padmavathi Ponnuru, Jared Iacovelli, Allan Hunter, Nadine Haddad, John Beard, James R. Connor, Sophie Vaulont, Joshua L. Dunaief, 2011, Investigative Ophthalmology and Visual Science on p. 109-118