James Connor

Distinguished Professor and Vice Chair of Neurosurgery

James Connor

Research Summary

Iron transport and toxicity in neurodegenerative diseases/oxidative cell injury.

Huck Affiliations


Publication Tags

Iron Brain Restless Legs Syndrome Neoplasms Fullerenes Therapeutics Transferrin Parkinson Disease Ferritins Glioblastoma Substantia Nigra Neuroblastoma Paraquat Medical Nanotechnology Pars Compacta Anisotropy Serum Homeostasis Disorder Carcinogenesis Macrophages Alzheimer Disease Magnetic Resonance Imaging Farmers Application

Most Recent Papers

Importance of the intersection of age and sex to understand variation in incidence and survival for primary malignant gliomas.

G Wang, G Cioffi, N Patil, K Waite, R Lanese, Q Ostrom, C Kruchko, M Berens, James Connor, J Lathia, J Rubin, J Barnholtz-Sloan, 2022, Neuro-oncology on p. 302-310

Low plasma serotonin linked to higher nigral iron in Parkinson’s disease

Leslie C. Jellen, Mechelle M. Lewis, Guangwei Du, Xi Wang, Martha L.Escobar Galvis, Stanislaw Krzyzanowski, Colt D. Capan, Amanda M. Snyder, James R. Connor, Lan Kong, Richard B. Mailman, Patrik Brundin, Lena Brundin, Xuemei Huang, 2021, Scientific Reports

Independently validated sex-specific nomograms for predicting survival in patients with newly diagnosed glioblastoma: NRG Oncology RTOG 0525 and 0825.

N Patil, E Somasundaram, K Waite, J Lathia, M Machtay, M Gilbert, James Connor, J Rubin, M Berens, R Buerki, S Choi, A Sloan, M Penas-Prado, L Ashby, D Blumenthal, M Werner-Wasik, G Hunter, J Flickinger, M Wendland, V Panet-Raymond, H Robins, S Pugh, M Mehta, J Barnholtz-Sloan, 2021, Journal of Neuro-Oncology on p. 363-372

Nutritional Yeast Ferritin Iron Complex: A Novel Source of Dietary Iron

James Connor, Unger Erica, R Keil, J Flanagan, S Patton, Gabriele Lubach, Martin Schafer, Christopher Coe, 2021, Nutritional Yeast Ferritin Iron Complex: A Novel Source of Dietary Iron on p. 122-131

Higher CSF Ferritin Heavy-Chain (Fth1) and Transferrin Predict Better Neurocognitive Performance in People with HIV.

H Kaur, W Bush, S Letendre, R Ellis, R Heaton, S Patton, James Connor, D Samuels, D Franklin, T Hulgan, A Kallianpur, 2021, Molecular neurobiology on p. 4842-4855

The Management of Restless Legs Syndrome

Michael H. Silber, Mark J. Buchfuhrer, Christopher J. Earley, Brian B. Koo, Mauro Manconi, John W. Winkelman, Phillip Becker, J. Andrew Berkowski, Stefan Clemens, James R. Connor, Sergi Ferré, Jennifer G. Hensley, Byron C. Jones, Elias G. Karroum, Brian Koo, William Ondo, Kathy Richards, Denise Sharon, Lynn Marie Trotti, George Uhl, Arthur S. Walters, 2021, Mayo Clinic Proceedings on p. 1921-1937

Association Between Iron and Cholesterol in Neuroblastomas.

S Lee, B Slagle-Webb, C Schengrund, J Zhu, James Connor, 2021, Anticancer Research on p. 2795-2804

HFE H63D Limits Nigral Vulnerability to Paraquat in Agricultural Workers.

E Wang, M Trojano, M Lewis, G Du, H Chen, G Brown, L Jellen, I Song, E Neely, L Kong, James Connor, X Huang, 2021, Toxicological Sciences on p. 47-57

A potential role for zinc in restless legs syndrome

Pan Chen, Julia Bornhorst, Stephanie Patton, Kanika Bagai, Rachana Nitin, Mahfuzur Miah, Dominic J. Hare, Kai Kysenius, Peter J. Crouch, Lan Xiong, Guy A. Rouleau, Tanja Schwerdtle, James Connor, Michael Aschner, Aaron B. Bowman, Arthur S. Walters, 2021, Sleep

Biological activity of a thiobarbituric acid compound in neuroblastomas

Sang Y. Lee, Becky Slagle-Webb, Arun K. Sharma, James R. Connor, 2021, Anticancer Research on p. 1171-1181

Most-Cited Papers

Altered Brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease)

Christopher J. Earley, James Connor, Diego Garcia-Borreguero, Peter Jenner, John Winkelman, Phyllis C. Zee, Richard Allen, 2014, Sleep Medicine on p. 1288-1301

The significance of ferritin in cancer

Ahmed A. Alkhateeb, James Connor, 2013, Biochimica et Biophysica Acta - Reviews on Cancer on p. 245-254

Preferential iron trafficking characterizes glioblastoma stem-like cells

David L. Schonberg, Tyler E. Miller, Qiulian Wu, William A. Flavahan, Nupur K. Das, James S. Hale, Christopher G. Hubert, Stephen C. Mack, Awad M. Jarrar, Robert T. Karl, Ann Mari Rosager, Anne M. Nixon, Paul J. Tesar, Petra Hamerlik, Bjarne W. Kristensen, Craig Horbinski, James Connor, Paul L. Fox, Justin D. Lathia, Jeremy N. Rich, 2015, Cancer Cell on p. 441-455

Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children

Richard P. Allen, Daniel L. Picchietti, Michael Auerbach, Yong Won Cho, James R. Connor, Christopher J. Earley, Diego Garcia-Borreguero, Suresh Kotagal, Mauro Manconi, William Ondo, Jan Ulfberg, John W. Winkelman, 2018, Sleep Medicine on p. 27-44

Application of fullerenes in nanomedicine

Anthony Dellinger, Zhiguo Zhou, James Connor, Ab Madhankumar, Sarala Pamujula, Christie M. Sayes, Christopher L. Kepley, 2013, Nanomedicine on p. 1191-1208

Quantitative susceptibility mapping of the midbrain in Parkinson's disease

Guangwei Du, Tian Liu, Mechelle M. Lewis, Lan Kong, Yi Wang, James Connor, Richard B. Mailman, Xuemei Huang, 2016, Movement Disorders on p. 317-324

Functional roles of transferrin in the brain

Dominique F. Leitner, James R. Connor, 2012, Biochimica et Biophysica Acta - General Subjects on p. 393-402

Ferritin stimulates breast cancer cells through an iron-independent mechanism and is localized within tumor-associated macrophages

Ahmed A. Alkhateeb, Bing Han, James Connor, 2013, Breast Cancer Research and Treatment on p. 733-744

The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin

Douglas G. Peters, James R. Connor, Mark D. Meadowcroft, 2015, Neurobiology of Disease on p. 49-65

A novel model for brain iron uptake: introducing the concept of regulation

Ian A. Simpson, Padmavathi Ponnuru, Marianne E. Klinger, Roland L. Myers, Kavi Devraj, Christopher L. Coe, Gabriele R. Lubach, Anthony Carruthers, James R. Connor, 2015, Journal of Cerebral Blood Flow and Metabolism on p. 48-57