James Connor

Distinguished Professor and Vice Chair of Neurosurgery

H110 Neurosurgery
Hershey, PA 17033
jrc3@psu.edu
717-531-4541

Bio & Links
Publications

Research Summary

Iron transport and toxicity in neurodegenerative diseases/oxidative cell injury.

Huck Affiliations

Center for Malaria Research

Publication Tags

Iron Neoplasms Glioblastoma Brain Therapeutics Parkinson Disease Fullerenes Ferritins Transferrin Survival Restless Legs Syndrome Substantia Nigra Biomarkers Liquid Biopsy Medical Nanotechnology Proteins Cerebrospinal Fluid Homeostasis Carcinogenesis Macrophages Magnetic Resonance Imaging Alzheimer Disease Inflammation Apoferritins Dioxygen

Most Recent Publications

Regulation of brain iron uptake by apo- and holo-transferrin is dependent on sex and delivery protein

Stephanie L. Baringer, Elizabeth B. Neely, Kondaiah Palsa, Ian A. Simpson, James R. Connor, 2022, Fluids and Barriers of the CNS

Plasma IL13Rα2 as a novel liquid biopsy biomarker for glioblastoma

Vladimir Khristov, Darya Nesterova, Mara Trifoi, Taylor Clegg, Annika Daya, Thomas Barrett, Emily Tufano, Ganesh Shenoy, Bhavyata Pandya, Gela Beselia, Nataliya Smith, Oliver Mrowczynski, Brad Zacharia, Kristin Waite, Justin Lathia, Jill Barnholtz-Sloan, James Connor, 2022, Journal of Neuro-Oncology on p. 743-752

Neuropharmacological Study of Posaconazole for Glioblastoma: A Phase 0 Clinical Trial Protocol

Debarati Bhanja, Jeffrey Neighbors, James Connor, Gelareh Zadeh, Seyed Alireza Mansouri, 2022, Neurosurgery on p. 658-665

Importance of the intersection of age and sex to understand variation in incidence and survival for primary malignant gliomas

Gi Ming Wang, Gino Cioffi, Nirav Patil, Kristin A. Waite, Robert Lanese, Quinn T. Ostrom, Carol Kruchko, Michael E. Berens, James R. Connor, Justin D. Lathia, Joshua B. Rubin, Jill S. Barnholtz-Sloan, 2022, Neuro-Oncology on p. 302-310

Dynamics of Nigral Iron Accumulation in Parkinson's Disease: From Diagnosis to Late Stage

Guangwei Du, Ernest Wang, Christopher Sica, Hairong Chen, Sol De Jesus, Mechelle Lewis, Lan Kong, James Connor, Richard B. Mailman, Xuemei Huang, 2022, Movement Disorders on p. 1654-1662

Tumor-Derived Biomarkers in Liquid Biopsy of Glioblastoma

Vladimir Khristov, Andrea Lin, Zachary Freedman, Jacob Staub, Ganesh Shenoy, Oliver Mrowczynski, Elias Rizk, Brad Zacharia, James Connor, 2022, World Neurosurgery

Low plasma serotonin linked to higher nigral iron in Parkinson’s disease

L Jellen, Mechelle M. Lewis, Guangwei Du, X Wang, Galvis MLE, Martha L.Escobar Galvis, S Krzyzanowski, C Capan, A Snyder, James R. Connor, Lan Kong, Richard B. Mailman, P Brundin, L Brundin, Xuemei Huang, 2021, Scientific Reports on p. 24384

Independently validated sex-specific nomograms for predicting survival in patients with newly diagnosed glioblastoma: NRG Oncology RTOG 0525 and 0825

N Patil, E Somasundaram, K Waite, J Lathia, M Machtay, M Gilbert, James Connor, J Rubin, M Berens, R Buerki, S Choi, A Sloan, M Penas-Prado, L Ashby, D Blumenthal, M Werner-Wasik, G Hunter, J Flickinger, M Wendland, V Panet-Raymond, H Robins, S Pugh, M Mehta, J Barnholtz-Sloan, 2021, Journal of Neuro-Oncology on p. 363-372

Nutritional Yeast Ferritin Iron Complex: A Novel Source of Dietary Iron

James Connor, Unger Erica, R Keil, J Flanagan, S Patton, Gabriele Lubach, Martin Schafer, Christopher Coe, 2021, Nutritional Yeast Ferritin Iron Complex: A Novel Source of Dietary Iron on p. 122-131

Higher CSF Ferritin Heavy-Chain (Fth1) and Transferrin Predict Better Neurocognitive Performance in People with HIV

Harpreet Kaur, William S. Bush, Scott L. Letendre, Ronald J. Ellis, Robert K. Heaton, Stephanie M. Patton, James R. Connor, David C. Samuels, Donald R. Franklin, Todd Hulgan, Asha R. Kallianpur, 2021, Molecular Neurobiology on p. 4842-4855

Most-Cited Papers

Altered Brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease)

Christopher J. Earley, James Connor, Diego Garcia-Borreguero, Peter Jenner, John Winkelman, Phyllis C. Zee, Richard Allen, 2014, Sleep Medicine on p. 1288-1301

Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells

David L. Schonberg, Tyler E. Miller, Qiulian Wu, William A. Flavahan, Nupur K. Das, James S. Hale, Christopher G. Hubert, Stephen C. Mack, Awad M. Jarrar, Robert T. Karl, Ann Mari Rosager, Anne M. Nixon, Paul J. Tesar, Petra Hamerlik, Bjarne W. Kristensen, Craig Horbinski, James Connor, Paul L. Fox, Justin D. Lathia, Jeremy N. Rich, 2015, Cancer Cell on p. 441-455

The significance of ferritin in cancer: Anti-oxidation, inflammation and tumorigenesis

Ahmed A. Alkhateeb, James Connor, 2013, Biochimica et Biophysica Acta - Reviews on Cancer on p. 245-254

Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report

Richard P. Allen, Daniel L. Picchietti, Michael Auerbach, Yong Won Cho, James R. Connor, Christopher J. Earley, Diego Garcia-Borreguero, Suresh Kotagal, Mauro Manconi, William Ondo, Jan Ulfberg, John W. Winkelman, 2018, Sleep Medicine on p. 27-44

Application of fullerenes in nanomedicine: An update

Anthony Dellinger, Zhiguo Zhou, James Connor, Ab Madhankumar, Sarala Pamujula, Christie M. Sayes, Christopher L. Kepley, 2013, Nanomedicine on p. 1191-1208

Quantitative susceptibility mapping of the midbrain in Parkinson's disease

Guangwei Du, Tian Liu, Mechelle M. Lewis, Lan Kong, Yi Wang, James Connor, Richard B. Mailman, Xuemei Huang, 2016, Movement Disorders on p. 317-324

Ferritin stimulates breast cancer cells through an iron-independent mechanism and is localized within tumor-associated macrophages

Ahmed A. Alkhateeb, Bing Han, James Connor, 2013, Breast Cancer Research and Treatment on p. 733-744