James Connor

Distinguished Professor and Vice Chair of Neurosurgery

James Connor

Research Summary

Iron transport and toxicity in neurodegenerative diseases/oxidative cell injury.

Huck Affiliations

Links

Publication Tags

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Iron Brain Fullerenes Ferritins Neoplasms Restless Legs Syndrome Glioblastoma Medical Nanotechnology Stem Cells Therapeutics Homeostasis Endothelial Cells Carcinogenesis Macrophages Alzheimer Disease Parkinson Disease Apoferritins Diagnostics Dioxygen Exosomes Neoplastic Stem Cells Practice Guidelines Child Physiological Transport Mesencephalon

Most Recent Publications

Common Mutation in the HFE Gene Modifies Recovery After Intracerebral Hemorrhage.

T Helmuth, R Kumari, K Palsa, E Neely, B Slagle-Webb, S Simon, James Connor, 2023, Stroke

Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin.

S Baringer, A Lukacher, K Palsa, H Kim, E Lippmann, V Spiegelman, I Simpson, James Connor, 2023, Journal of neurochemistry

Uptake of H-ferritin by Glioblastoma stem cells and its impact on their invasion capacity

Bhavyata Pandya Shesh, Becky Slagle-Webb, Ganesh Shenoy, Vladimir Khristov, Brad E. Zacharia, James R. Connor, 2023, Journal of Cancer Research and Clinical Oncology on p. 9691-9703

Sexually dimorphic effect of H-ferritin genetic manipulation on survival and tumor microenvironment in a mouse model of glioblastoma

Bhavyata Pandya Shesh, Vonn Walter, Kondaiah Palsa, Becky Slagle-Webb, Elizabeth Neely, Todd Schell, James R. Connor, 2023, Journal of Neuro-Oncology on p. 569-586

A Closer Look at the Role of Iron in Glioblastoma.

G Shenoy, James Connor, 2023, Neuro-oncology

Photodynamic Therapy for Glioblastoma: Illuminating the Path toward Clinical Applicability

Debarati Bhanja, Hannah Wilding, Angel Baroz, Mara Trifoi, Ganesh Shenoy, Becky Slagle-Webb, Daniel Hayes, Yasaman Soudagar, James Connor, Alireza Mansouri, 2023, Cancers

A novel view of ferritin in cancer

Bhavyata (Pandya) Shesh, James R. Connor, 2023, Biochimica et Biophysica Acta - Reviews on Cancer

Apo- and holo-transferrin differentially interact with hephaestin and ferroportin in a novel mechanism of cellular iron release regulation

Stephanie Baringer, Kondaiah Palsa, Vladimir S. Spiegelman, Ian A. Simpson, James Connor, 2023, Journal of Biomedical Science

Brain iron acquisition: An overview of homeostatic regulation and disease dysregulation

Stephanie L. Baringer, Ian A. Simpson, James R. Connor, 2023, Journal of Neurochemistry on p. 625-642

Exosomes are involved in iron transport from human blood–brain barrier endothelial cells and are modified by endothelial cell iron status

Kondaiah Palsa, Stephanie L. Baringer, Ganesh Shenoy, Vladimir S. Spiegelman, Ian A. Simpson, James Connor, 2023, Journal of Biological Chemistry

Most-Cited Papers

Altered Brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease)

Christopher J. Earley, James Connor, Diego Garcia-Borreguero, Peter Jenner, John Winkelman, Phyllis C. Zee, Richard Allen, 2014, Sleep Medicine on p. 1288-1301

Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells

David L. Schonberg, Tyler E. Miller, Qiulian Wu, William A. Flavahan, Nupur K. Das, James S. Hale, Christopher G. Hubert, Stephen C. Mack, Awad M. Jarrar, Robert T. Karl, Ann Mari Rosager, Anne M. Nixon, Paul J. Tesar, Petra Hamerlik, Bjarne W. Kristensen, Craig Horbinski, James Connor, Paul L. Fox, Justin D. Lathia, Jeremy N. Rich, 2015, Cancer Cell on p. 441-455

The significance of ferritin in cancer: Anti-oxidation, inflammation and tumorigenesis

Ahmed A. Alkhateeb, James Connor, 2013, Biochimica et Biophysica Acta - Reviews on Cancer on p. 245-254

Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report

Richard P. Allen, Daniel L. Picchietti, Michael Auerbach, Yong Won Cho, James R. Connor, Christopher J. Earley, Diego Garcia-Borreguero, Suresh Kotagal, Mauro Manconi, William Ondo, Jan Ulfberg, John W. Winkelman, 2018, Sleep Medicine on p. 27-44

Application of fullerenes in nanomedicine: An update

Anthony Dellinger, Zhiguo Zhou, James Connor, Ab Madhankumar, Sarala Pamujula, Christie M. Sayes, Christopher L. Kepley, 2013, Nanomedicine on p. 1191-1208

Quantitative susceptibility mapping of the midbrain in Parkinson's disease

Guangwei Du, T Liu, Mechelle M. Lewis, Lan Kong, Y Wang, James Connor, Richard B. Mailman, Xuemei Huang, 2016, Movement Disorders on p. 317-324

The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin

Douglas G. Peters, James R. Connor, Mark D. Meadowcroft, 2015, Neurobiology of Disease on p. 49-65

Ferritin stimulates breast cancer cells through an iron-independent mechanism and is localized within tumor-associated macrophages

Ahmed A. Alkhateeb, Bing Han, James Connor, 2013, Breast Cancer Research and Treatment on p. 733-744

Iron uptake and transport across physiological barriers

Kari A. Duck, James R. Connor, 2016, BioMetals on p. 573-591

A novel model for brain iron uptake: Introducing the concept of regulation

Ian A. Simpson, Padmavathi Ponnuru, Marianne E. Klinger, Roland L. Myers, Kavi Devraj, Christopher L. Coe, Gabriele R. Lubach, Anthony Carruthers, James R. Connor, 2015, Journal of Cerebral Blood Flow and Metabolism on p. 48-57