James Broach

Professor and Chair, Biochemistry and Molecular Biology

James Broach

Huck Affiliations

Publication Tags

Yeasts Genome Genes Nucleotides Amyotrophic Lateral Sclerosis Yeast Degradation Neoplasms Ribose Mutation Brain Carbon Starvation Oxidative Stress Thyroid Neoplasms Salvaging Kinesin Mutagenesis Phosphates Food Chromosomes Therapeutics Nutrients Proteins Nucleosides

Most Recent Papers

Mutational profile of endometrial hyperplasia and risk of progression to endometrioid adenocarcinoma.

M Russo, Jordan Newell, L Budurlean, K Houser, K Sheldon, Joshua Kesterson, Rebecca Phaeton, Carrie Hossler, Jennifer Rosenberg, David Degraff, L Shuman, James Broach, Joshua Warrick, 2020, Cancer on p. 2775-2783

Genetic variants implicate dual oxidase-2 in familial and sporadic nonmedullary thyroid cancer

Darrin V. Bann, Qunyan Jin, Kathryn E. Sheldon, Kenneth R. Houser, Lan Nguyen, Joshua I. Warrick, Maria J. Baker, James R. Broach, Glenn S. Gerhard, David Goldenberg, 2019, Cancer Research on p. 5490-5499

Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis

Sara Bandres-Ciga, Alastair J. Noyce, Gibran Hemani, Aude Nicolas, Andrea Calvo, Gabriele Mora, Alessandro Arosio, Marco Barberis, Ilaria Bartolomei, Stefania Battistini, Michele Benigni, Giuseppe Borghero, Maura Brunetti, Andrea Calvo, Stefania Cammarosano, Antonino Cannas, Antonio Canosa, Margherita Capasso, Claudia Caponnetto, Carla Caredda, Paola Carrera, Federico Casale, Sebastiano Cavallaro, Adriano Chiò, Tiziana Colletti, Francesca L. Conforti, Amelia Conte, Lucia Corrado, Emanuela Costantino, Sandra D'Alfonso, Antonio Fasano, Cinzia Femiano, Carlo Ferrarese, Nicola Fini, Gianluca Floris, Giuseppe Fuda, Fabio Giannini, Maurizio Grassano, Antonio Ilardi, Vincenzo La Bella, Serena Lattante, Giancarlo Logroscino, Francesco O. Logullo, Daniela Loi, Christian Lunetta, Gianluigi Mancardi, Paola Mandich, Jessica Mandrioli, Umberto Manera, Giuseppe Marangi, 2019, Annals of Neurology on p. 470-481

Molecular characterization of tumors meeting diagnostic criteria for the non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)

Christopher Pool, Vonn Walter, Darrin Bann, David Goldenberg, James Broach, Max Hennessy, Elizabeth Cottrill, Erik Washburn, Nicole Williams, Henry Crist, Yuka Imamura, Joshua Warrick, 2019, Virchows Archiv on p. 341-351

CD4 T cells control development and maintenance of brain-resident CD8 T cells during polyomavirus infection

Taryn E. Mockus, Shwetank, Matthew D. Lauver, Heather M. Ren, Colleen S. Netherby, Tarik Salameh, Yuka Imamura Kawasawa, Feng Yue, James R. Broach, Aron E. Lukacher, 2018, PLoS pathogens

Integrative detection and analysis of structural variation in cancer genomes

Jesse R. Dixon, Jie Xu, Vishnu Dileep, Ye Zhan, Fan Song, Victoria T. Le, Galip Gürkan Yardımcı, Abhijit Chakraborty, Darrin V. Bann, Yanli Wang, Royden Clark, Lijun Zhang, Hongbo Yang, Tingting Liu, Sriranga Iyyanki, Lin An, Christopher Pool, Takayo Sasaki, Juan Carlos Rivera-Mulia, Hakan Ozadam, Bryan R. Lajoie, Rajinder Kaul, Michael Buckley, Kristen Lee, Morgan Diegel, Dubravka Pezic, Christina Ernst, Suzana Hadjur, Duncan T. Odom, John A. Stamatoyannopoulos, James Broach, Ross Cameron Hardison, Ferhat Ay, William Stafford Noble, Job Dekker, David M. Gilbert, Feng Yue, 2018, Nature Genetics on p. 1388-1398

Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism

Erin G. Conlon, Delphine Fagegaltier, Phaedra Agius, Julia Davis-Porada, James Gregory, Isabel Hubbard, Kristy Kang, Duyang Kim, Hemali Phatnani, Neil A. Shneider, James L. Manley, Justin Kwan, Dhruv Sareen, James R. Broach, Zachary Simmons, Ximena Arcila-Londono, Edward B. Lee, Vivianna M. Van Deerlin, Ernest Fraenkel, Lyle W. Ostrow, Frank Baas, Noah Zaitlen, James D. Berry, Andrea Malaspina, Pietro Fratta, Gregory A. Cox, Leslie M. Thompson, Steve Finkbeiner, Efthimios Dardiotis, Timothy M. Miller, Siddharthan Chandran, Suvankar Pal, Eran Hornstein, Daniel J. Macgowan, Terry Heiman-Patterson, Molly G. Hammell, Nikolaos A. Patsopoulos, Joshua Dubnau, Avindra Nath, 2018, eLife

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

Aude Nicolas, Kevin P. Kenna, Alan E. Renton, Nicola Ticozzi, Faraz Faghri, Ruth Chia, Janice A. Dominov, Brendan J. Kenna, Mike A. Nalls, Pamela Keagle, Alberto M. Rivera, Wouter van Rheenen, Natalie A. Murphy, Joke J.F.A. van Vugt, Joshua T. Geiger, Rick A. Van der Spek, Hannah A. Pliner, Shankaracharya, Bradley N. Smith, Giuseppe Marangi, Simon D. Topp, Yevgeniya Abramzon, Athina Soragia Gkazi, John D. Eicher, Aoife Kenna, Francesco O. Logullo, Isabella L. Simone, Giancarlo Logroscino, Fabrizio Salvi, Ilaria Bartolomei, Giuseppe Borghero, Maria Rita Murru, Emanuela Costantino, Carla Pani, Roberta Puddu, Carla Caredda, Valeria Piras, Stefania Tranquilli, Stefania Cuccu, Daniela Corongiu, Maurizio Melis, Antonio Milia, Francesco Marrosu, Maria Giovanna Marrosu, Gianluca Floris, Antonino Cannas, Margherita Capasso, Claudia Caponnetto, Gianluigi Mancardi, Paola Origone, 2018, Neuron on p. 1268-1283.e6

A possible role for platelet-activating factor receptor in amyotrophic lateral sclerosis treatment

Marcelo R.S. Briones, Amanda M. Snyder, Renata C. Ferreira, Elizabeth B. Neely, James R. Connor, James R. Broach, 2018, Frontiers in Neurology

Expansion of C9ORF72 in amyotrophic lateral sclerosis correlates with brain-computer interface performance

Andrew Geronimo, Kathryn E. Sheldon, James R. Broach, Zachary Simmons, Steven J. Schiff, 2017, Scientific reports

Most-Cited Papers

Yeast cells can access distinct quiescent states

Maja M. Klosinska, Christopher A. Crutchfield, Patrick H. Bradley, Joshua D. Rabinowitz, James R. Broach, 2011, Genes and Development on p. 336-349

Initiation of the TORC1-Regulated G<sub>0</sub> Program Requires Igo1/2, which License Specific mRNAs to Evade Degradation via the 5′-3′ mRNA Decay Pathway

Nicolas Talarek, Elisabetta Cameroni, Malika Jaquenoud, Xuan Luo, Séverine Bontron, Soyeon Lippman, Geeta Devgan, Michael Snyder, James R. Broach, Claudio De Virgilio, 2010, Molecular cell on p. 345-355

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

Aude Nicolas, Kevin P. Kenna, Alan E. Renton, Nicola Ticozzi, Faraz Faghri, Ruth Chia, Janice A. Dominov, Brendan J. Kenna, Mike A. Nalls, Pamela Keagle, Alberto M. Rivera, Wouter van Rheenen, Natalie A. Murphy, Joke J.F.A. van Vugt, Joshua T. Geiger, Rick A. Van der Spek, Hannah A. Pliner, Shankaracharya, Bradley N. Smith, Giuseppe Marangi, Simon D. Topp, Yevgeniya Abramzon, Athina Soragia Gkazi, John D. Eicher, Aoife Kenna, Francesco O. Logullo, Isabella L. Simone, Giancarlo Logroscino, Fabrizio Salvi, Ilaria Bartolomei, Giuseppe Borghero, Maria Rita Murru, Emanuela Costantino, Carla Pani, Roberta Puddu, Carla Caredda, Valeria Piras, Stefania Tranquilli, Stefania Cuccu, Daniela Corongiu, Maurizio Melis, Antonio Milia, Francesco Marrosu, Maria Giovanna Marrosu, Gianluca Floris, Antonino Cannas, Margherita Capasso, Claudia Caponnetto, Gianluigi Mancardi, Paola Origone, 2018, Neuron on p. 1268-1283.e6

Genetic heterogeneity of amyotrophic lateral sclerosis

Xiaowei W. Su, James Broach, James Connor, Glenn S. Gerhard, Zachary Simmons, 2014, Muscle and Nerve on p. 786-803

The Yeast Environmental Stress Response Regulates Mutagenesis Induced by Proteotoxic Stress

Erika Shor, Catherine A. Fox, James R. Broach, 2013, PLoS genetics

Regulation of Yeast Pyruvate Kinase by Ultrasensitive Allostery Independent of Phosphorylation

Yi Fan Xu, Xin Zhao, David S. Glass, Farnaz Absalan, David H. Perlman, James R. Broach, Joshua D. Rabinowitz, 2012, Molecular cell on p. 52-62

Noise and interlocking signaling pathways promote distinct transcription factor dynamics in response to different stresses

Natalia Petrenko, Razvan V. Chereji, Megan N. McClean, Alexandre V. Morozov, James R. Broach, 2013, Molecular biology of the cell on p. 2045-2057

Nucleotide degradation and ribose salvage in yeast

Yi Fan Xu, Fabien Létisse, Farnaz Absalan, Wenyun Lu, Ekaterina Kuznetsova, Greg Brown, Amy A. Caudy, Alexander F. Yakunin, James R. Broach, Joshua D. Rabinowitz, 2013, Molecular Systems Biology

Integrative detection and analysis of structural variation in cancer genomes

Jesse R. Dixon, Jie Xu, Vishnu Dileep, Ye Zhan, Fan Song, Victoria T. Le, Galip Gürkan Yardımcı, Abhijit Chakraborty, Darrin V. Bann, Yanli Wang, Royden Clark, Lijun Zhang, Hongbo Yang, Tingting Liu, Sriranga Iyyanki, Lin An, Christopher Pool, Takayo Sasaki, Juan Carlos Rivera-Mulia, Hakan Ozadam, Bryan R. Lajoie, Rajinder Kaul, Michael Buckley, Kristen Lee, Morgan Diegel, Dubravka Pezic, Christina Ernst, Suzana Hadjur, Duncan T. Odom, John A. Stamatoyannopoulos, James Broach, Ross Cameron Hardison, Ferhat Ay, William Stafford Noble, Job Dekker, David M. Gilbert, Feng Yue, 2018, Nature Genetics on p. 1388-1398

The yeast genome undergoes significant topological reorganization in quiescence

Mark T. Rutledge, Mariano Russo, Jon Matthew Belton, Job Dekker, James R. Broach, 2015, Nucleic Acids Research on p. 8299-8313