James Broach
Distinguished Professor and Chair of Biochemistry and Molecular Biology
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H171 Biochemistry & Molecular Biology
Hershey, PA - jrb62@psu.edu
- 717-531-5470
Publication Tags
Yeasts Genome Genes Neoplasms Mutation Hydrocephalus Brain Cerebrospinal Fluid Paenibacillus Amyotrophic Lateral Sclerosis Infections Genomics Coinfection Infection Mutagenesis Exome Transcription Factors Nutrients Growth Chromosomes Glucose Therapeutics Dna Saccharum Chromosome MappingMost Recent Papers
Complete genome sequence and analysis of a Saccharomyces cerevisiae strain used for sugarcane spirit production
Ane Catarine Tosi Costa, Jacob Hornick, Tathiana Ferreira Sá Antunes, Alexandre Martins Costa Santos, A. Alberto R. Fernandes, James R. Broach, Patricia M.B. Fernandes, 2021, Revista de Microbiologia on p. 1087-1095
Increased Incidence of IKZF1 deletions and IGH-CRLF2 translocations in B-ALL of Hispanic/Latino children—a novel health disparity
Gordana Raca, Hisham Abdel-Azim, Feng Yue, James Broach, Jonathon L. Payne, Mark E. Reeves, Chandrika Gowda, Joseph Schramm, Dhimant Desai, Elanora Dovat, Tommy Hu, Arthur S. Berg, Deepa Bhojwani, Kimberly J. Payne, Sinisa Dovat, 2021, Leukemia on p. 2399-2402
Immune activation during Paenibacillus brain infection in African infants with frequent cytomegalovirus co-infection
Albert M. Isaacs, Sarah U. Morton, Mercedeh Movassagh, Qiang Zhang, Christine Hehnly, Lijun Zhang, Diego M. Morales, Shamim A. Sinnar, Jessica E. Ericson, Edith Mbabazi-Kabachelor, Peter Ssenyonga, Justin Onen, Ronnie Mulondo, Mady Hornig, Benjamin C. Warf, James R. Broach, R. Reid Townsend, David D. Limbrick, Joseph N. Paulson, Steven J. Schiff, 2021, iScience
Identification of somatic structural variants in solid tumors by optical genome mapping
David Y. Goldrich, Brandon Labarge, Scott Chartrand, Lijun Zhang, Henry B. Sadowski, Yang Zhang, Khoa Pham, Hannah Way, Chi Yu Jill Lai, Andy Wing Chun Pang, Benjamin Clifford, Alex R. Hastie, Mark Oldakowski, David Goldenberg, James R. Broach, 2021, Journal of Personalized Medicine on p. 1-21
Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis
Ramita Dewan, Ruth Chia, Jinhui Ding, Richard A. Hickman, Thor D. Stein, Yevgeniya Abramzon, Sarah Ahmed, Marya S. Sabir, Makayla K. Portley, Arianna Tucci, Kristina Ibáñez, F. N.U. Shankaracharya, Pamela Keagle, Giacomina Rossi, Paola Caroppo, Fabrizio Tagliavini, Maria L. Waldo, Per M. Johansson, Christer F. Nilsson, Adelani Adeleye, Camille Alba, Dagmar Bacikova, Daniel N. Hupalo, Elisa Mc Grath Martinez, Harvey B. Pollard, Gauthaman Sukumar, Anthony R. Soltis, Meila Tuck, Xijun Zhang, Matthew D. Wilkerson, Bradley N. Smith, Nicola Ticozzi, Claudia Fallini, Athina Soragia Gkazi, Simon D. Topp, Jason Kost, Emma L. Scotter, Kevin P. Kenna, Jack W. Miller, Cinzia Tiloca, Caroline Vance, Eric W. Danielson, Claire Troakes, Claudia Colombrita, Safa Al-Sarraj, Elizabeth A. Lewis, Andrew King, Daniela Calini, Zachary Simmons, James R. Broach, 2021, Neuron on p. 448-460.e4
An integrative ENCODE resource for cancer genomics
Jing Zhang, Donghoon Lee, Vineet Dhiman, Peng Jiang, Jie Xu, Patrick McGillivray, Hongbo Yang, Jason Liu, William Meyerson, Declan Clarke, Mengting Gu, Shantao Li, Shaoke Lou, Jinrui Xu, Lucas Lochovsky, Matthew Ung, Lijia Ma, Shan Yu, Qin Cao, Arif Harmanci, Koon Kiu Yan, Anurag Sethi, Gamze Gürsoy, Michael Rutenberg Schoenberg, Joel Rozowsky, Jonathan Warrell, Prashant Emani, Yucheng T. Yang, Timur Galeev, Xiangmeng Kong, Shuang Liu, Xiaotong Li, Jayanth Krishnan, Yanlin Feng, Juan Carlos Rivera-Mulia, Jessica Adrian, James R. Broach, Michael Bolt, Jennifer Moran, Dominic Fitzgerald, Vishnu Dileep, Tingting Liu, Shenglin Mei, Takayo Sasaki, Claudia Trevilla-Garcia, Su Wang, Yanli Wang, Chongzhi Zang, Daifeng Wang, Robert J. Klein, Michael Snyder, David M. Gilbert, Kevin Yip, Chao Cheng, Feng Yue, X. Shirley Liu, Kevin P. White, Mark Gerstein, 2020, Nature Communications
Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus
Sheng Chih Jin, Weilai Dong, Adam J. Kundishora, Shreyas Panchagnula, Andres Moreno-De-Luca, Charuta G. Furey, August A. Allocco, Rebecca L. Walker, Carol Nelson-Williams, Hannah Smith, Ashley Dunbar, Sierra Conine, Qiongshi Lu, Xue Zeng, Michael C. Sierant, James R. Knight, William Sullivan, Phan Q. Duy, Tyrone DeSpenza, Benjamin C. Reeves, Jason K. Karimy, Arnaud Marlier, Christopher Castaldi, Irina R. Tikhonova, Boyang Li, Helena Perez Peña, James R. Broach, Edith M. Kabachelor, Peter Ssenyonga, Christine Hehnly, Li Ge, Boris Keren, Andrew T. Timberlake, June Goto, Francesco T. Mangano, James M. Johnston, William E. Butler, Benjamin C. Warf, Edward R. Smith, Steven J. Schiff, David D. Limbrick, Gregory Heuer, Eric M. Jackson, Bermans J. Iskandar, Shrikant Mane, Shozeb Haider, Bulent Guclu, Yasar Bayri, Yener Sahin, Charles C. Duncan, Michael L.J. Apuzzo, Michael L. DiLuna, Ellen J. Hoffman, Nenad Sestan, Laura R. Ment, Seth L. Alper, Kaya Bilguvar, Daniel H. Geschwind, Murat Günel, Richard P. Lifton, Kristopher T. Kahle, 2020, Nature Medicine on p. 1754-1765
Paenibacillus infection with frequent viral coinfection contributes to postinfectious hydrocephalus in Ugandan infants
Joseph N. Paulson, Brent L. Williams, Christine Hehnly, Nischay Mishra, Shamim A. Sinnar, Lijun Zhang, Paddy Ssentongo, Edith Mbabazi-Kabachelor, Dona S.S. Wijetunge, Benjamin Von Bredow, Ronnie Mulondo, Julius Kiwanuka, Francis Bajunirwe, Joel Bazira, Lisa M. Bebell, Kathy Burgoine, Mara Couto-Rodriguez, Jessica E. Ericson, Tim Erickson, Matthew Ferrari, Melissa Gladstone, Cheng Guo, Murali Haran, Mady Hornig, Albert M. Isaacs, Brian Nsubuga Kaaya, Sheila M. Kangere, Abhaya V. Kulkarni, Elias Kumbakumba, Xiaoxiao Li, David D. Limbrick, Joshua Magombe, Sarah U. Morton, John Mugamba, James Ng, Peter Olupot-Olupot, Justin Onen, Mallory R. Peterson, Farrah Roy, Kathryn Sheldon, Reid Townsend, Andrew D. Weeks, Andrew J. Whalen, John Quackenbush, Peter Ssenyonga, Michael Y. Galperin, Mathieu Almeida, Hannah Atkins, Benjamin C. Warf, W. Ian Lipkin, James R. Broach, Steven J. Schiff, 2020, Science Translational Medicine
Mutational profile of endometrial hyperplasia and risk of progression to endometrioid adenocarcinoma
Mariano Russo, Jordan M. Newell, Laura Budurlean, Kenneth R. Houser, Kathryn Sheldon, Joshua Kesterson, Rebecca Phaeton, Carrie Hossler, Jennifer Rosenberg, David DeGraff, Lauren Shuman, James R. Broach, Joshua I. Warrick, 2020, Cancer on p. 2775-2783
Genetic variants implicate dual oxidase-2 in familial and sporadic nonmedullary thyroid cancer
Darrin V. Bann, Qunyan Jin, Kathryn E. Sheldon, Kenneth R. Houser, Lan Nguyen, Joshua I. Warrick, Maria J. Baker, James R. Broach, Glenn S. Gerhard, David Goldenberg, 2019, Cancer Research on p. 5490-5499
Most-Cited Papers
Nutritional control of growth and development in yeast
James R. Broach, 2012, Genetics on p. 73-105
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
Aude Nicolas, Kevin P. Kenna, Alan E. Renton, Nicola Ticozzi, Faraz Faghri, Ruth Chia, Janice A. Dominov, Brendan J. Kenna, Mike A. Nalls, Pamela Keagle, Alberto M. Rivera, Wouter van Rheenen, Natalie A. Murphy, Joke J.F.A. van Vugt, Joshua T. Geiger, Rick A. Van der Spek, Hannah A. Pliner, Shankaracharya, Bradley N. Smith, Giuseppe Marangi, Simon D. Topp, Yevgeniya Abramzon, Athina Soragia Gkazi, John D. Eicher, Aoife Kenna, Francesco O. Logullo, Isabella L. Simone, Giancarlo Logroscino, Fabrizio Salvi, Ilaria Bartolomei, Giuseppe Borghero, Maria Rita Murru, Emanuela Costantino, Carla Pani, Roberta Puddu, Carla Caredda, Valeria Piras, Stefania Tranquilli, Stefania Cuccu, Daniela Corongiu, Maurizio Melis, Antonio Milia, Francesco Marrosu, Maria Giovanna Marrosu, Gianluca Floris, Antonino Cannas, Margherita Capasso, Claudia Caponnetto, Zachary Simmons, James Broach, 2018, Neuron on p. 1268-1283.e6
Yeast cells can access distinct quiescent states
Maja M. Klosinska, Christopher A. Crutchfield, Patrick H. Bradley, Joshua D. Rabinowitz, James R. Broach, 2011, Genes and Development on p. 336-349
Integrative detection and analysis of structural variation in cancer genomes
Jesse R. Dixon, Jie Xu, Vishnu Dileep, Ye Zhan, Fan Song, Victoria T. Le, Galip Gürkan Yardımcı, Abhijit Chakraborty, Darrin V. Bann, Yanli Wang, Royden Clark, Lijun Zhang, Hongbo Yang, Tingting Liu, Sriranga Iyyanki, Lin An, Christopher Pool, Takayo Sasaki, Juan Carlos Rivera-Mulia, Hakan Ozadam, Bryan R. Lajoie, Rajinder Kaul, Michael Buckley, Kristen Lee, Morgan Diegel, Dubravka Pezic, Christina Ernst, Suzana Hadjur, Duncan T. Odom, John A. Stamatoyannopoulos, James R. Broach, Ross C. Hardison, Ferhat Ay, William Stafford Noble, Job Dekker, David M. Gilbert, Feng Yue, 2018, Nature Genetics on p. 1388-1398
Genetic heterogeneity of amyotrophic lateral sclerosis: implications for clinical practice and research
Xiaowei W. Su, James Broach, James Connor, Glenn S. Gerhard, Zachary Simmons, 2014, Muscle and Nerve on p. 786-803
The Yeast Environmental Stress Response Regulates Mutagenesis Induced by Proteotoxic Stress
Erika Shor, Catherine A. Fox, James R. Broach, 2013, PLoS Genetics
Noise and interlocking signaling pathways promote distinct transcription factor dynamics in response to different stresses
Natalia Petrenko, Razvan V. Chereji, Megan N. McClean, Alexandre V. Morozov, James R. Broach, 2013, Molecular Biology of the Cell on p. 2045-2057
Regulation of Yeast Pyruvate Kinase by Ultrasensitive Allostery Independent of Phosphorylation
Yi Fan Xu, Xin Zhao, David S. Glass, Farnaz Absalan, David H. Perlman, James R. Broach, Joshua D. Rabinowitz, 2012, Molecular Cell on p. 52-62
Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis
Sara Bandres-Ciga, Alastair J. Noyce, Gibran Hemani, Aude Nicolas, Andrea Calvo, Gabriele Mora, Alessandro Arosio, Marco Barberis, Ilaria Bartolomei, Stefania Battistini, Michele Benigni, Giuseppe Borghero, Maura Brunetti, Stefania Cammarosano, Antonino Cannas, Antonio Canosa, Margherita Capasso, Claudia Caponnetto, Carla Caredda, Paola Carrera, Federico Casale, Sebastiano Cavallaro, Adriano Chiò, Tiziana Colletti, Francesca L. Conforti, Amelia Conte, Lucia Corrado, Emanuela Costantino, Sandra D'Alfonso, Antonio Fasano, Cinzia Femiano, Carlo Ferrarese, Nicola Fini, Gianluca Floris, Giuseppe Fuda, Fabio Giannini, Maurizio Grassano, Antonio Ilardi, Vincenzo La Bella, Serena Lattante, Giancarlo Logroscino, Francesco O. Logullo, Daniela Loi, Christian Lunetta, Gianluigi Mancardi, Paola Mandich, Jessica Mandrioli, Umberto Manera, James Broach, Zachary Simmons, 2019, Annals of Neurology on p. 470-481
The yeast genome undergoes significant topological reorganization in quiescence
Mark T. Rutledge, Mariano Russo, Jon Matthew Belton, Job Dekker, James R. Broach, 2015, Nucleic Acids Research on p. 8299-8313