James Broach
Distinguished Professor and Chair of Biochemistry and Molecular Biology
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H171 Biochemistry & Molecular Biology
Hershey, PA - jrb62@psu.edu
- 717-531-5470
Publication Tags
Yeasts Amyotrophic Lateral Sclerosis Genome Mutation Genes Retroelements Mutagenesis Oxidative Stress Microbiota Neuroglia Industry Mothers Neoplasms Neurodegenerative Diseases Genetic Engineering Chromosomes Motor Neurons Therapeutics Gene Randomized Controlled Trials 16s Ribosomal Rna Rrna Genes Growth Fever Computational BiologyMost Recent Publications
Cell environment shapes TDP-43 function with implications in neuronal and muscle disease
Urša Šušnjar, Neva Škrabar, Anna Leigh Brown, Yasmine Abbassi, Hemali Phatnani, H. Phatnani, P. Fratta, J. Kwan, D. Sareen, J. R. Broach, Z. Simmons, X. Arcila-Londono, E. B. Lee, V. M. Van Deerlin, N. A. Shneider, E. Fraenkel, L. W. Ostrow, F. Baas, J. D. Berry, O. Butovsky, R. H. Baloh, Ophir Shalem, T. Heiman-Patterson, L. Stefanis, S. Chandran, S. Pal, C. Smith, A. Malaspina, M. G. Hammell, N. A. Patsopoulos, J. Dubnau, M. Poss, B. Zhang, N. Zaitlen, E. Hornstein, T. M. Miller, E. Dardiotis, R. Bowser, V. Menon, M. Harms, N. Atassi, D. J. Lange, D. J. MacGowan, C. McMillan, E. Aronica, B. Harris, J. Ravits, J. Crary, L. M. Thompson, T. Raj, 2022, Communications Biology
Differential richness inference for 16S rRNA marker gene surveys
M. Senthil Kumar, Eric V. Slud, Christine Hehnly, Lijun Zhang, James Broach, Rafael A. Irizarry, Steven Schiff, Joseph N. Paulson, 2022, Genome Biology
mirTarRnaSeq: An R/Bioconductor Statistical Package for miRNA-mRNA Target Identification and Interaction Analysis
Mercedeh Movassagh, Sarah U. Morton, Christine Hehnly, Jasmine Smith, Trang T. Doan, Rafael Irizarry, James R. Broach, Steven J. Schiff, Jeffrey A. Bailey, Joseph N. Paulson, 2022, BMC Genomics
Human Papillomavirus Integration Strictly Correlates with Global Genome Instability in Head and Neck Cancer
Brandon Labarge, Max Hennessy, Lijun Zhang, David Goldrich, Scott Chartrand, Carson Purnell, Sage Wright, David Goldenberg, James R. Broach, 2022, Cell Growth and Differentiation on p. 1420-1428
NASHFit: A randomized controlled trial of an exercise training program to reduce clotting risk in patients with NASH
Jonathan G. Stine, Ian R. Schreibman, Alison J. Faust, Jessica Dahmus, Benjamin Stern, Christopher Soriano, Gloriany Rivas, Breianna Hummer, Scot R. Kimball, Nate R. Geyer, Vernon M. Chinchilli, Rohit Loomba, Kathryn Schmitz, Christopher Sciamanna, Cindy Strine, Rachel Wentzel, Sara Marlin, Chris Sica, Jeff Vesek, Elaine Eyster, Lawrence Sinoway, Kathy Bentz, Nancy Handley, Brenda Hershey Fell, Shirlynn Mottilla, Christine Christ, Susan George, Terry Novchich, Megan Beyer, Kofi Clarke, Tiffany Myers, Martha Glading-Steinruck, Karen Krok, Thomas Ma, Thomas Riley, Elizabeth Thompson, Heather Tressler, James Broach, Trang Doan, Sue Patrick, Syndi Reed, Chris Hamilton, Kristin Slavoski, Deborah Tregea, 2022, Hepatology on p. 172-185
Cytomegalovirus infections in infants in Uganda: Newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus
Christine Hehnly, Paddy Ssentongo, Lisa M. Bebell, Kathy Burgoine, Joel Bazira, Claudio Fronterre, Elias Kumbakumba, Ronald Mulondo, Edith Mbabazi-Kabachelor, Sarah U. Morton, Joseph Ngonzi, Moses Ochora, Peter Olupot-Olupot, John Mugamba, Justin Onen, Drucilla J. Roberts, Kathryn Sheldon, Shamim A. Sinnar, Jasmine Smith, Peter Ssenyonga, Julius Kiwanuka, Joseph N. Paulson, Frederick A. Meier, Jessica E. Ericson, James R. Broach, Steven J. Schiff, 2022, International Journal of Infectious Diseases on p. 24-33
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
Anna Leigh Brown, Oscar G. Wilkins, Matthew J. Keuss, Sarah E. Hill, Matteo Zanovello, Weaverly Colleen Lee, Alexander Bampton, Flora C.Y. Lee, Laura Masino, Yue A. Qi, Sam Bryce-Smith, Ariana Gatt, Martina Hallegger, Delphine Fagegaltier, Hemali Phatnani, Hemali Phatnani, Justin Kwan, Dhruv Sareen, James R. Broach, Zachary Simmons, Ximena Arcila-Londono, Edward B. Lee, Vivianna M. Van Deerlin, Neil A. Shneider, Ernest Fraenkel, Lyle W. Ostrow, Frank Baas, Noah Zaitlen, James D. Berry, Andrea Malaspina, Pietro Fratta, Gregory A. Cox, Leslie M. Thompson, Steve Finkbeiner, Efthimios Dardiotis, Timothy M. Miller, Siddharthan Chandran, Suvankar Pal, Eran Hornstein, Daniel J. MacGowan, Terry Heiman-Patterson, Molly G. Hammell, Nikolaos A. Patsopoulos, Oleg Butovsky, Joshua Dubnau, Avindra Nath, Robert Bowser, Matthew Harms, Eleonora Aronica, Mary Poss, 2022, Nature on p. 131-137
Microbial adaptive evolution
Aiqin Shi, Feiyu Fan, James R. Broach, 2022, Journal of Industrial Microbiology and Biotechnology
Vaginal microbiome topic modeling of laboring Ugandan women with and without fever
Mercedeh Movassagh, Lisa M. Bebell, Kathy Burgoine, Christine Hehnly, Lijun Zhang, Kim Moran, Kathryn Sheldon, Shamim A. Sinnar, Edith Mbabazi-Kabachelor, Elias Kumbakumba, Joel Bazira, Moses Ochora, Ronnie Mulondo, Brian Kaaya Nsubuga, Andrew D. Weeks, Melissa Gladstone, Peter Olupot-Olupot, Joseph Ngonzi, Drucilla J. Roberts, Frederick A. Meier, Rafael A. Irizarry, James R. Broach, Steven J. Schiff, Joseph N. Paulson, 2021, npj Biofilms and Microbiomes
An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients
Hemali Phatnani, Justin Kwan, Dhruv Sareen, James R. Broach, Zachary Simmons, Ximena Arcila-Londono, Edward B. Lee, Vivianna M. Van Deerlin, Neil A. Shneider, Ernest Fraenkel, Lyle W. Ostrow, Frank Baas, Noah Zaitlen, James D. Berry, Andrea Malaspina, Pietro Fratta, Gregory A. Cox, Leslie M. Thompson, Steve Finkbeiner, Efthimios Dardiotis, Timothy M. Miller, Siddharthan Chandran, Suvankar Pal, Eran Hornstein, Daniel J. MacGowan, Terry Heiman-Patterson, Molly G. Hammell, Nikolaos A. Patsopoulos, Oleg Butovsky, Joshua Dubnau, Avindra Nath, Robert Bowser, Matt Harms, Mary Poss, Jennifer Phillips-Cremins, John Crary, Nazem Atassi, Dale J. Lange, Darius J. Adams, Leonidas Stefanis, Marc Gotkine, Robert H. Baloh, Suma Babu, Towfique Raj, Sabrina Paganoni, Ophir Shalem, Colin Smith, Bin Zhang, Brent Harris, Iris Broce, 2021, iScience
Most-Cited Papers
Nutritional control of growth and development in yeast
James R. Broach, 2012, Genetics on p. 73-105
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
Aude Nicolas, Kevin P. Kenna, Alan E. Renton, Nicola Ticozzi, Faraz Faghri, Ruth Chia, Janice A. Dominov, Brendan J. Kenna, Mike A. Nalls, Pamela Keagle, Alberto M. Rivera, Wouter van Rheenen, Natalie A. Murphy, Joke J.F.A. van Vugt, Joshua T. Geiger, Rick A. Van der Spek, Hannah A. Pliner, Shankaracharya, Bradley N. Smith, Giuseppe Marangi, Simon D. Topp, Yevgeniya Abramzon, Athina Soragia Gkazi, John D. Eicher, Aoife Kenna, Francesco O. Logullo, Isabella L. Simone, Giancarlo Logroscino, Fabrizio Salvi, Ilaria Bartolomei, Giuseppe Borghero, Maria Rita Murru, Emanuela Costantino, Carla Pani, Roberta Puddu, Carla Caredda, Valeria Piras, Stefania Tranquilli, Stefania Cuccu, Daniela Corongiu, Maurizio Melis, Antonio Milia, Francesco Marrosu, Maria Giovanna Marrosu, Gianluca Floris, Antonino Cannas, Margherita Capasso, Claudia Caponnetto, Zachary Simmons, James Broach, 2018, Neuron on p. 1268-1283.e6
Integrative detection and analysis of structural variation in cancer genomes
Jesse R. Dixon, Jie Xu, Vishnu Dileep, Ye Zhan, Fan Song, Victoria T. Le, Galip Gürkan Yardımcı, Abhijit Chakraborty, Darrin V. Bann, Yanli Wang, Royden Clark, Lijun Zhang, Hongbo Yang, Tingting Liu, Sriranga Iyyanki, Lin An, Christopher Pool, Takayo Sasaki, Juan Carlos Rivera-Mulia, Hakan Ozadam, Bryan R. Lajoie, Rajinder Kaul, Michael Buckley, Kristen Lee, Morgan Diegel, Dubravka Pezic, Christina Ernst, Suzana Hadjur, Duncan T. Odom, John A. Stamatoyannopoulos, James R. Broach, Ross C. Hardison, Ferhat Ay, William Stafford Noble, Job Dekker, David M. Gilbert, Feng Yue, 2018, Nature Genetics on p. 1388-1398
Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia
Oliver H. Tam, Nikolay V. Rozhkov, Regina Shaw, Duyang Kim, Isabel Hubbard, Samantha Fennessey, Nadia Propp, Hemali Phatnani, Justin Kwan, Dhruv Sareen, James R. Broach, Zachary Simmons, Ximena Arcila-Londono, Edward B. Lee, Vivianna M. Van Deerlin, Neil A. Shneider, Ernest Fraenkel, Lyle W. Ostrow, Frank Baas, Noah Zaitlen, James D. Berry, Andrea Malaspina, Pietro Fratta, Gregory A. Cox, Leslie M. Thompson, Steve Finkbeiner, Efthimios Dardiotis, Timothy M. Miller, Siddharthan Chandran, Suvankar Pal, Eran Hornstein, Daniel J. MacGowan, Terry Heiman-Patterson, Molly G. Hammell, Nikolaos A. Patsopoulos, Oleg Butovsky, Joshua Dubnau, Avindra Nath, Robert Bowser, Matt Harms, Eleonora Aronica, Mary Poss, Jennifer Phillips-Cremins, John Crary, Nazem Atassi, Dale J. Lange, Darius J. Adams, Leonidas Stefanis, Marc Gotkine, Robert Baloh, 2019, Cell Reports on p. 1164-1177.e5
The Yeast Environmental Stress Response Regulates Mutagenesis Induced by Proteotoxic Stress
Erika Shor, Catherine A. Fox, James R. Broach, 2013, PLoS Genetics
Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis
Sara Bandres-Ciga, Alastair J. Noyce, Gibran Hemani, Aude Nicolas, Andrea Calvo, Gabriele Mora, Alessandro Arosio, Marco Barberis, Ilaria Bartolomei, Stefania Battistini, Michele Benigni, Giuseppe Borghero, Maura Brunetti, Stefania Cammarosano, Antonino Cannas, Antonio Canosa, Margherita Capasso, Claudia Caponnetto, Carla Caredda, Paola Carrera, Federico Casale, Sebastiano Cavallaro, Adriano Chiò, Tiziana Colletti, Francesca L. Conforti, Amelia Conte, Lucia Corrado, Emanuela Costantino, Sandra D'Alfonso, Antonio Fasano, Cinzia Femiano, Carlo Ferrarese, Nicola Fini, Gianluca Floris, Giuseppe Fuda, Fabio Giannini, Maurizio Grassano, Antonio Ilardi, Vincenzo La Bella, Serena Lattante, Giancarlo Logroscino, Francesco O. Logullo, Daniela Loi, Christian Lunetta, Gianluigi Mancardi, Paola Mandich, Jessica Mandrioli, Umberto Manera, James Broach, Zachary Simmons, 2019, Annals of Neurology on p. 470-481
Genetic heterogeneity of amyotrophic lateral sclerosis: implications for clinical practice and research
Xiaowei W. Su, James Broach, James Connor, Glenn S. Gerhard, Zachary Simmons, 2014, Muscle and Nerve on p. 786-803
Regulation of Yeast Pyruvate Kinase by Ultrasensitive Allostery Independent of Phosphorylation
Yi Fan Xu, Xin Zhao, David S. Glass, Farnaz Absalan, David H. Perlman, James R. Broach, Joshua D. Rabinowitz, 2012, Molecular Cell on p. 52-62
Noise and interlocking signaling pathways promote distinct transcription factor dynamics in response to different stresses
Natalia Petrenko, Razvan V. Chereji, Megan N. McClean, Alexandre V. Morozov, James R. Broach, 2013, Molecular Biology of the Cell on p. 2045-2057
The yeast genome undergoes significant topological reorganization in quiescence
Mark T. Rutledge, Mariano Russo, Jon Matthew Belton, Job Dekker, James R. Broach, 2015, Nucleic Acids Research on p. 8299-8313