Ilias Georgakopoulos-Soares

Assistant Professor

Ilias Georgakopoulos-Soares

Research Summary

The development and implementation of new computational methods in genomics and molecular biology, with the aim of identifying genetic biomarkers for the diagnosis, monitoring, and treatment of human diseases, including bacterial and viral infections and of aging-associated diseases including neurodegenerative diseases and cancer.

Huck Graduate Students

Huck Affiliations

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Most Recent Publications

Very low rates of thyroid function testing in human studies evaluating basal metabolic rate

Camille Moeckel, Dionysios Chartoumpekis, Panos Ziros, Ilias Georgakopoulos-Soares, Gerasimos Sykiotis,

Machine Intelligence in Pancreatic Cancer

Nelson Yee, Fenglong Ma, Ilias Georgakopoulos-Soares, Springer Nature

A multi-omics analysis of effector and resting treg cells in pan-cancer

Anna Maria Chalepaki, Marios Gkoris, Irene Chondrou, Malamati Kourti, Ilias Georgakopoulos-Soares, Apostolos Zaravinos, 2025, Computers in Biology and Medicine

Massively parallel characterization of transcriptional regulatory elements

Vikram Agarwal, Fumitaka Inoue, Max Schubach, Dmitry Penzar, Beth K. Martin, Pyaree Mohan Dash, Pia Keukeleire, Zicong Zhang, Ajuni Sohota, Jingjing Zhao, Ilias Georgakopoulos-Soares, William S. Noble, Galip Gürkan Yardımcı, Ivan V. Kulakovskiy, Martin Kircher, Jay Shendure, Nadav Ahituv, 2025, Nature on p. 411-420

Ribosomal DNA arrays are the most H-DNA rich element in the human genome

Nikol Chantzi, Candace S.Y. Chan, Michail Patsakis, Akshatha Nayak, Austin Montgomery, Ioannis Mouratidis, Ilias Georgakopoulos-Soares, 2025, NAR Genomics and Bioinformatics

Characterization of Exhausted T Cell Signatures in Pan-Cancer Settings

Rifat Tasnim Juthi, Saiful Arefeen Sazed, Manvita Mareboina, Apostolos Zaravinos, Ilias Georgakopoulos-Soares, 2025, International Journal of Molecular Sciences

Comprehensive Analysis of Granzymes and Perforin Family Genes in Multiple Cancers

Manvita Mareboina, Katrina Bakhl, Stephanie Agioti, Nelson S. Yee, Ilias Georgakopoulos-Soares, Apostolos Zaravinos, 2025, Biomedicines

The topography of nullomer-emerging mutations and their relevance to human disease

Candace S.Y. Chan, Ioannis Mouratidis, Austin Montgomery, Georgios Christos Tsiatsianis, Nikol Chantzi, Martin Hemberg, Nadav Ahituv, Ilias Georgakopoulos-Soares, 2025, Computational and Structural Biotechnology Journal on p. 1-11

A Multi-Omics Analysis of a Mitophagy-Related Signature in Pan-Cancer

Nora Agir, Ilias Georgakopoulos-Soares, Apostolos Zaravinos, 2025, International Journal of Molecular Sciences

Identification of the shortest species-specific oligonucleotide sequences

Ioannis Mouratidis, Maxwell A. Konnaris, Nikol Chantzi, Candace S.Y. Chan, Michail Patsakis, Kimonas Provatas, Austin Montgomery, Fotis A. Baltoumas, Congzhou M. Sha, Manvita Mareboina, Georgios A. Pavlopoulos, Dionysios V. Chartoumpekis, Ilias Georgakopoulos-Soares, 2025, Genome Research on p. 279-295

Most-Cited Papers

Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis

Mia Petljak, Ludmil B. Alexandrov, Jonathan S. Brammeld, Stacey Price, David C. Wedge, Sebastian Grossmann, Kevin J. Dawson, Young Seok Ju, Francesco Iorio, Jose M.C. Tubio, Ching Chiek Koh, Ilias Georgakopoulos-Soares, Bernardo Rodríguez-Martín, Burçak Otlu, Sarah O'Meara, Adam P. Butler, Andrew Menzies, Shriram G. Bhosle, Keiran Raine, David R. Jones, Jon W. Teague, Kathryn Beal, Calli Latimer, Laura O'Neill, Jorge Zamora, Elizabeth Anderson, Nikita Patel, Mark Maddison, Bee Ling Ng, Jennifer Graham, Mathew J. Garnett, Ultan McDermott, Serena Nik-Zainal, Peter J. Campbell, Michael R. Stratton, 2019, Cell on p. 1282-1294.e20

EMT Factors and Metabolic Pathways in Cancer

Ilias Georgakopoulos-Soares, Dionysios V. Chartoumpekis, Venetsana Kyriazopoulou, Apostolos Zaravinos, 2020, Frontiers in Oncology

A practical framework and online tool for mutational signature analyses show intertissue variation and driver dependencies

Andrea Degasperi, Tauanne Amarante, Jan Czarnecki, Scott Shooter, Xueqing Zou, Dominik Glodzik, Sandro Morganella, Arjun Nanda, Cherif Badja, Gene Koh, Sophie Momen, Ilias Georgakopoulos-Soares, João Dias, Jamie Young, Yasin Memari, Helen Davies, Serena Nik-Zainal, 2020, Nature Cancer on p. 249-263

Noncanonical secondary structures arising from non-B DNA motifs are determinants of mutagenesis

Ilias Georgakopoulos-Soares, Sandro Morganella, Naman Jain, Martin Hemberg, Serena Nik-Zainal, 2018, Genome Research on p. 1264-1271

lentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements

M. Grace Gordon, Fumitaka Inoue, Beth Martin, Max Schubach, Vikram Agarwal, Sean Whalen, Shiyun Feng, Jingjing Zhao, Tal Ashuach, Ryan Ziffra, Anat Kreimer, Ilias Georgakopoulous-Soares, Nir Yosef, Chun Jimmie Ye, Katherine S. Pollard, Jay Shendure, Martin Kircher, Nadav Ahituv, 2020, Nature Protocols on p. 2387-2412

Alternative splicing modulation by G-quadruplexes

Ilias Georgakopoulos-Soares, Guillermo E. Parada, Hei Yuen Wong, Ragini Medhi, Giulia Furlan, Roberto Munita, Eric A. Miska, Chun Kit Kwok, Martin Hemberg, 2022, Nature Communications

Surface antibacterial properties enhanced through engineered textures and surface roughness: A review

Ilias Georgakopoulos-Soares, Emmanouil L. Papazoglou, Panagiotis Karmiris-Obratański, Nikolaos E. Karkalos, Angelos P. Markopoulos, 2023, Colloids and Surfaces B: Biointerfaces

Deletion of CTCF sites in the SHH locus alters enhancer–promoter interactions and leads to acheiropodia

Aki Ushiki, Yichi Zhang, Chenling Xiong, Jingjing Zhao, Ilias Georgakopoulos-Soares, Lauren Kane, Kirsty Jamieson, Michael J. Bamshad, Deborah A. Nickerson, Yin Shen, Laura A. Lettice, Elizabeth Lemos Silveira-Lucas, Florence Petit, Nadav Ahituv, 2021, Nature Communications

Transcription factor binding site orientation and order are major drivers of gene regulatory activity

Ilias Georgakopoulos-Soares, Chengyu Deng, Vikram Agarwal, Candace S.Y. Chan, Jingjing Zhao, Fumitaka Inoue, Nadav Ahituv, 2023, Nature Communications

High-throughput characterization of the role of non-B DNA motifs on promoter function

Ilias Georgakopoulos-Soares, J Victorino, GE Parada, V Agarwal, J Zhao, HY Wong, MI Umar, O Elor, A Muhwezi, JY An, SJ Sanders, CK Kwok, F Inoue, M Hemberg, N Ahituv, 2022, Cell Genomics