Elizabeth Proctor
Assistant Professor of Neurosurgery, Pharmacology, Biomedical Engineering, and Engineering Science & Mechanics

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HCAR 3039
Hershey, PA - exp412@psu.edu
- 717-531-5922
Research Summary
Systems biology of complex disease. Integration of heterogeneous data types across length scales.
Huck Affiliations
- Bioinformatics and Genomics
- Neuroscience Institute
- Center for Neural Engineering
- Center for Neurotechnology in Mental Health Research
Links
Publication Tags
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Proteins Hemodynamics Sleep Cytokines Alzheimer Disease Inflammation Membranes Neurons Amyotrophic Lateral Sclerosis Brain Neurovascular Coupling Autophagy Protein Molecular Dynamics Simulation Hemodynamic Metformin Mutation T Lymphocytes Lymphocytes Energy Metabolism Cells Peptides Pathology Type 2 Diabetes Mellitus BacteriaMost Recent Publications
Apolipoprotein E ε4 modulates astrocyte neuronal support functions in the presence of amyloid-β
Rebecca M. Fleeman, Madison K. Kuhn, Dennis C. Chan, Elizabeth A. Proctor, 2023, Journal of Neurochemistry on p. 536-549
Predictive link between systemic metabolism and cytokine signatures in the brain of apolipoprotein E ε4 mice
Rebecca Fleeman, A Snyder, M Kuhn, D Chan, G Smith, Nicole Crowley, Amy Arnold, Elizabeth Proctor, 2022, Neurobiology of Aging on p. 154-169
Monosialotetrahexosylganglioside Promotes Early Aβ42 Oligomer Formation and Maintenance
D Zhang, J Wang, R Fleeman, M Kuhn, Matthew T. Swulius, Elizabeth Proctor, Nikolay V. Dokholyan, 2022, ACS Chemical Neuroscience on p. 1979-1991
Astrocytic Propagation of Tau in the Context of Alzheimer's Disease
Rebecca M. Fleeman, Elizabeth A. Proctor, 2021, Frontiers in Cellular Neuroscience
Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry
Andrew Simonson^, Andrew W. Simonson, A Mongia, Agustey Mongia^, Matthew R. Aronson, Agustey S. Mongia, M Aronson, Matthew Aronson^, John N. Alumasa, Dennis Chan, Adam Bolotsky, Atip Lawanprasert^, A Lawanprasert, Michael Howe, Aida Ebrahimi, Elizabeth Proctor, Adam Bolotsky, T. Mal, Kenneth C. Keiler, Scott H. Medina, Christy George, S Ebrahimi, A Ebrahimi, A Baughn, Elizabeth Proctor, Kenneth Keiler, Scott Medina*, S Medina, 2020, Nature Biomedical Engineering on p. 467-480
Neurovascular coupling and bilateral connectivity during nrem and rem sleep
Kevin L. Turner, Kyle W. Gheres, Elizabeth A. Proctor, Patrick J. Drew, 2020, eLife on p. 1
Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model
Elizabeth A. Proctor, Shauna M. Dineen, Stephen C. Van Nostrand, Madison K. Kuhn, Christopher D. Barrett, Douglas K. Brubaker, Michael B. Yaffe, Douglas A. Lauffenburger, Lisa R. Leon, 2020, Journal of Thrombosis and Haemostasis on p. 1900-1910
Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation
Leena P. Bharath, Madhur Agrawal, Grace McCambridge, Dequina A. Nicholas, Hatice Hasturk, Jing Liu, Kai Jiang, Rui Liu, Zhenheng Guo, Jude Deeney, Caroline M. Apovian, Jennifer Snyder-Cappione, Gregory S. Hawk, Rebecca M. Fleeman, Riley M.F. Pihl, Katherine Thompson, Anna C. Belkina, Licong Cui, Elizabeth A. Proctor, Philip A. Kern, Barbara S. Nikolajczyk, 2020, Cell Metabolism on p. 44-55.e6
A non-local model of the propagation of action potentials in myelinated neurons
Corina S. Drapaca, Sahin Ozdemir, Elizabeth A. Proctor, 2020, Emerging Science Journal on p. 148-164
HFE gene expression impacts sex-based survival in glioblastoma
D Nesterova, V. Midya, B Zacharia, Elizabeth Proctor, S. Lee, L. Stetson, J Lathia, J Rubin, K Waite, M Berens, J Barnholtz-Sloan, J Connor, 2020, Neuro-Oncology Advances on p. vddaa001
Most-Cited Papers
Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation
Leena P. Bharath, Madhur Agrawal, Grace McCambridge, Dequina A. Nicholas, Hatice Hasturk, Jing Liu, Kai Jiang, Rui Liu, Zhenheng Guo, Jude Deeney, Caroline M. Apovian, Jennifer Snyder-Cappione, Gregory S. Hawk, Rebecca M. Fleeman, Riley M.F. Pihl, Katherine Thompson, Anna C. Belkina, Licong Cui, Elizabeth A. Proctor, Philip A. Kern, Barbara S. Nikolajczyk, 2020, Cell Metabolism on p. 44-55.e6
Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis
Elizabeth A. Proctor, Lanette Fee, Yazhong Tao, Rachel L. Redler, James M. Fay, Yuliang Zhang, Zhengjian Lv, Ian P. Mercer, Mohanish Deshmukh, Yuri L. Lyubchenko, Nikolay V. Dokholyan, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 614-619
Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes
Dequina A. Nicholas, Elizabeth A. Proctor, Madhur Agrawal, Anna C. Belkina, Stephen C. Van Nostrand, Leena Panneerseelan-Bharath, Albert R. Jones, Forum Raval, Blanche C. Ip, Min Zhu, Jose M. Cacicedo, Chloe Habib, Nestor Sainz-Rueda, Leah Persky, Patrick G. Sullivan, Barbara E. Corkey, Caroline M. Apovian, Philip A. Kern, Douglas A. Lauffenburger, Barbara S. Nikolajczyk, 2019, Cell Metabolism on p. 447-461.e5
Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis
Dequina Nicholas, Elizabeth A. Proctor, Forum M. Raval, Blanche C. Ip, Chloe Habib, Eleni Ritou, Tom N. Grammatopoulos, Devin Steenkamp, Hans Dooms, Caroline M. Apovian, Douglas A. Lauffenburger, Barbara S. Nikolajczyk, 2017, PLoS One
Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening
Levi B. Wood, Ashley R. Winslow, Elizabeth A. Proctor, Declan McGuone, Daniel A. Mordes, Matthew P. Frosch, Bradley T. Hyman, Douglas A. Lauffenburger, Kevin M. Haigis, 2015, Scientific Reports
Applications of Discrete Molecular Dynamics in biology and medicine
Elizabeth A. Proctor, Nikolay V. Dokholyan, 2016, Current Opinion in Structural Biology on p. 9-13
Rational coupled dynamics network manipulation rescues disease-relevant mutant cystic fibrosis transmembrane conductance regulator
Elizabeth A. Proctor, Pradeep Kota, Andrei A. Aleksandrov, Lihua He, John R. Riordan, Nikolay V. Dokholyan, 2015, Chemical Science on p. 1237-1246
Cu,Zn-superoxide dismutase without Zn is folded but catalytically inactive
Sean Nedd, Rachel L. Redler, Elizabeth A. Proctor, Nikolay V. Dokholyan, Anastassia N. Alexandrova, 2014, Journal of Molecular Biology on p. 4112-4124
Neurovascular coupling and bilateral connectivity during nrem and rem sleep
Kevin L. Turner, Kyle W. Gheres, Elizabeth A. Proctor, Patrick J. Drew, 2020, eLife on p. 1
Computational approaches to understanding protein aggregation in neurodegeneration
Rachel L. Redler, David Shirvanyants, Onur Dagliyan, Feng Ding, Doo Nam Kim, Pradeep Kota, Elizabeth A. Proctor, Srinivas Ramachandran, Arpit Tandon, Nikolay V. Dokholyan, 2014, Journal of Molecular Cell Biology on p. 104-115
News Articles Featuring Elizabeth Proctor
Aug 25, 2022
Penn State awarded $1.6M to study if COVID-19 contributes to cognitive decline
As populations around the globe age, dementia — often caused by Alzheimer’s disease and related disorders — is a growing health issue for older adults worldwide.
Full Article
Sep 17, 2019
Research suggests how environmental toxin produced by algae may lead to ALS
Can a computer be used to explain why an environmental toxin might lead to neurodegenerative disease? According to Penn State College of Medicine researchers, a computer generated-simulation allowed them to see how a toxin produced by algal blooms in saltwater might cause Amyotrophic Lateral Sclerosis (ALS).
Full Article