Elizabeth Proctor

Assistant Professor of Neurosurgery, Pharmacology, Biomedical Engineering, and Engineering Science & Mechanics

HCAR 3039
Hershey, PA
exp412@psu.edu
717-531-5922

Research Summary

Systems biology of complex disease. Integration of heterogeneous data types across length scales.

Huck Affiliations

Bioinformatics and Genomics

Neuroscience Institute

Center for Neural Engineering

Publication Tags

Proteins Inflammation Cytokines Molecular Dynamics Simulation Alzheimer Disease Membranes Type 2 Diabetes Mellitus Neurons Protein Binding Amyotrophic Lateral Sclerosis T Lymphocytes Metformin Hemodynamics Fatty Acids Autophagy Protein Sleep Mutation Lymphocytes Peptides Cells Energy Metabolism Pathology Bacteria Genes

Most Recent Publications

Monosialotetrahexosylganglioside Promotes Early Aβ42 Oligomer Formation and Maintenance

Dong Yan Zhang, Jian Wang, Rebecca M. Fleeman, Madison K. Kuhn, Matthew T. Swulius, Elizabeth A. Proctor, Nikolay V. Dokholyan, 2022, ACS Chemical Neuroscience on p. 1979-1991

Astrocytic Propagation of Tau in the Context of Alzheimer's Disease

Rebecca M. Fleeman, Elizabeth A. Proctor, 2021, Frontiers in Cellular Neuroscience

Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry

Andrew W. Simonson, Andrew Simonson^, Agustey Mongia^, Matthew R. Aronson, A Mongia, Matthew Aronson^, M Aronson, Agustey S. Mongia, John N. Alumasa, Dennis Chan, A Lawanprasert, Adam Bolotsky, Atip Lawanprasert^, Aida Ebrahimi, Michael Howe, Elizabeth Proctor, Adam Bolotsky, Tapas K. Mal, Kenneth C. Keiler, Christy George, Scott H. Medina, S Ebrahimi, A Ebrahimi, A Baughn, Elizabeth Proctor, Kenneth Keiler, Scott Medina*, S Medina, 2020, Nature Biomedical Engineering on p. 467-480

Neurovascular coupling and bilateral connectivity during nrem and rem sleep

Kevin L. Turner, Kyle W. Gheres, Elizabeth A. Proctor, Patrick J. Drew, 2020, eLife on p. 1

Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model

Elizabeth A. Proctor, Shauna M. Dineen, Stephen C. Van Nostrand, Madison K. Kuhn, Christopher D. Barrett, Douglas K. Brubaker, Michael B. Yaffe, Douglas A. Lauffenburger, Lisa R. Leon, 2020, Journal of Thrombosis and Haemostasis on p. 1900-1910

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

Leena P. Bharath, Madhur Agrawal, Grace McCambridge, Dequina A. Nicholas, Hatice Hasturk, Jing Liu, Kai Jiang, Rui Liu, Zhenheng Guo, Jude Deeney, Caroline M. Apovian, Jennifer Snyder-Cappione, Gregory S. Hawk, Rebecca M. Fleeman, Riley M.F. Pihl, Katherine Thompson, Anna C. Belkina, Licong Cui, Elizabeth A. Proctor, Philip A. Kern, Barbara S. Nikolajczyk, 2020, Cell Metabolism on p. 44-55.e6

A non-local model of the propagation of action potentials in myelinated neurons

Corina S. Drapaca, Sahin Ozdemir, Elizabeth A. Proctor, 2020, Emerging Science Journal on p. 148-164

Sexually dimorphic impact of the iron-regulating gene, HFE, on survival in glioblastoma

Darya S. Nesterova, Vishal Midya, Brad E. Zacharia, Elizabeth A. Proctor, Sang Lee, Lindsay C. Stetson, Justin D. Lathia, Joshua B0 Rubin, Kristin A. Waite, Michael E. Berens, Jill S. Barnholtz-Sloan, James R. Connor, 2020, Neuro-Oncology Advances

HFE gene expression impacts sex-based survival in glioblastoma

D Nesterova, V. Midya, B Zacharia, Elizabeth Proctor, S. Lee, L. Stetson, J Lathia, J Rubin, K Waite, M Berens, J Barnholtz-Sloan, J Connor, 2020, Neuro-Oncology Advances on p. vddaa001

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes

Dequina A. Nicholas, Elizabeth A. Proctor, Madhur Agrawal, Anna C. Belkina, Stephen C. Van Nostrand, Leena Panneerseelan-Bharath, Albert R. Jones, Forum Raval, Blanche C. Ip, Min Zhu, Jose M. Cacicedo, Chloe Habib, Nestor Sainz-Rueda, Leah Persky, Patrick G. Sullivan, Barbara E. Corkey, Caroline M. Apovian, Philip A. Kern, Douglas A. Lauffenburger, Barbara S. Nikolajczyk, 2019, Cell Metabolism on p. 447-461.e5

Most-Cited Papers

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis

Elizabeth A. Proctor, Lanette Fee, Yazhong Tao, Rachel L. Redler, James M. Fay, Yuliang Zhang, Zhengjian Lv, Ian P. Mercer, Mohanish Deshmukh, Yuri L. Lyubchenko, Nikolay V. Dokholyan, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 614-619

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes

Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening

Levi B. Wood, Ashley R. Winslow, Elizabeth A. Proctor, Declan McGuone, Daniel A. Mordes, Matthew P. Frosch, Bradley T. Hyman, Douglas A. Lauffenburger, Kevin M. Haigis, 2015, Scientific Reports

Rational coupled dynamics network manipulation rescues disease-relevant mutant cystic fibrosis transmembrane conductance regulator

Elizabeth A. Proctor, Pradeep Kota, Andrei A. Aleksandrov, Lihua He, John R. Riordan, Nikolay V. Dokholyan, 2015, Chemical Science on p. 1237-1246

Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis

Dequina Nicholas, Elizabeth A. Proctor, Forum M. Raval, Blanche C. Ip, Chloe Habib, Eleni Ritou, Tom N. Grammatopoulos, Devin Steenkamp, Hans Dooms, Caroline M. Apovian, Douglas A. Lauffenburger, Barbara S. Nikolajczyk, 2017, PLoS One

Applications of Discrete Molecular Dynamics in biology and medicine

Elizabeth A. Proctor, Nikolay V. Dokholyan, 2016, Current Opinion in Structural Biology on p. 9-13

Cu,Zn-superoxide dismutase without Zn is folded but catalytically inactive

Sean Nedd, Rachel L. Redler, Elizabeth A. Proctor, Nikolay V. Dokholyan, Anastassia N. Alexandrova, 2014, Journal of Molecular Biology on p. 4112-4124

Computational approaches to understanding protein aggregation in neurodegeneration

Rachel L. Redler, David Shirvanyants, Onur Dagliyan, Feng Ding, Doo Nam Kim, Pradeep Kota, Elizabeth A. Proctor, Srinivas Ramachandran, Arpit Tandon, Nikolay V. Dokholyan, 2014, Journal of Molecular Cell Biology on p. 104-115

Discrete molecular dynamics distinguishes nativelike binding poses from decoys in difficult targets

Elizabeth Anne Proctor, Shuangye Yin, Alexander Tropsha, Nikolay Dokholyan, 2012, Biophysical Journal on p. 144-151

News Articles Featuring Elizabeth Proctor

Aug 25, 2022

Penn State awarded $1.6M to study if COVID-19 contributes to cognitive decline

As populations around the globe age, dementia — often caused by Alzheimer’s disease and related disorders — is a growing health issue for older adults worldwide.

Full Article

Sep 17, 2019

Research suggests how environmental toxin produced by algae may lead to ALS

Can a computer be used to explain why an environmental toxin might lead to neurodegenerative disease? According to Penn State College of Medicine researchers, a computer generated-simulation allowed them to see how a toxin produced by algal blooms in saltwater might cause Amyotrophic Lateral Sclerosis (ALS).