Elizabeth Proctor
Assistant Professor of Neurosurgery, Pharmacology, Biomedical Engineering, and Engineering Science & Mechanics
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HCAR 3039
Hershey, PA - exp412@psu.edu
- 717-531-5922
Research Summary
Systems biology of complex disease. Integration of heterogeneous data types across length scales.
Huck Affiliations
Links
Publication Tags
Proteins Cytokines Amyotrophic Lateral Sclerosis Inflammation Protein Type 2 Diabetes Mellitus Neurons Alzheimer Disease Peptides T Lymphocytes Pathogens Serine Metformin Hemodynamics Membrane Proteins Fatty Acids Superoxide Dismutase Etiology Molecular Dynamics Simulation Substitution Autophagy Sleep Alanine Toxicity MutationMost Recent Papers
Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry
Andrew W. Simonson, Agustey S. Mongia, Matthew R. Aronson, John N. Alumasa, Dennis C. Chan, Atip Lawanprasert, Michael D. Howe, Adam Bolotsky, Tapas K. Mal, Christy George, Aida Ebrahimi, Anthony D. Baughn, Elizabeth A. Proctor, Kenneth C. Keiler, Scott H. Medina, 2021, Nature Biomedical Engineering on p. 467-480
Astrocytic Propagation of Tau in the Context of Alzheimer's Disease
Rebecca M. Fleeman, Elizabeth A. Proctor, 2021, Frontiers in Cellular Neuroscience
Neurovascular coupling and bilateral connectivity during nrem and rem sleep
Kevin L. Turner, Kyle W. Gheres, Elizabeth A. Proctor, Patrick J. Drew, 2020, eLife on p. 1
Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model
Elizabeth A. Proctor, Shauna M. Dineen, Stephen C. Van Nostrand, Madison K. Kuhn, Christopher D. Barrett, Douglas K. Brubaker, Michael B. Yaffe, Douglas A. Lauffenburger, Lisa R. Leon, 2020, Journal of Thrombosis and Haemostasis on p. 1900-1910
Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation
Leena P. Bharath, Madhur Agrawal, Grace McCambridge, Dequina A. Nicholas, Hatice Hasturk, Jing Liu, Kai Jiang, Rui Liu, Zhenheng Guo, Jude Deeney, Caroline M. Apovian, Jennifer Snyder-Cappione, Gregory S. Hawk, Rebecca M. Fleeman, Riley M.F. Pihl, Katherine Thompson, Anna C. Belkina, Licong Cui, Elizabeth A. Proctor, Philip A. Kern, Barbara S. Nikolajczyk, 2020, Cell Metabolism on p. 44-55.e6
A non-local model of the propagation of action potentials in myelinated neurons
Corina S. Drapaca, Sahin Ozdemir, Elizabeth A. Proctor, 2020, Emerging Science Journal on p. 148-164
HFE gene expression impacts sex-based survival in glioblastoma
D Nesterova, V. Midya, B Zacharia, Elizabeth Proctor, S. Lee, L. Stetson, J Lathia, J Rubin, K Waite, M Berens, J Barnholtz-Sloan, J Connor, 2020, Neuro-Oncology Advances on p. vddaa001
Sexually dimorphic impact of the iron-regulating gene, HFE, on survival in glioblastoma
Darya S. Nesterova, Vishal Midya, Brad E. Zacharia, Elizabeth A. Proctor, Sang Lee, Lindsay C. Stetson, Justin D. Lathia, Joshua B0 Rubin, Kristin A. Waite, Michael E. Berens, Jill S. Barnholtz-Sloan, James R. Connor, 2020, Neuro-Oncology Advances
Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes
Dequina A. Nicholas, Elizabeth A. Proctor, Madhur Agrawal, Anna C. Belkina, Stephen C. Van Nostrand, Leena Panneerseelan-Bharath, Albert R. Jones, Forum Raval, Blanche C. Ip, Min Zhu, Jose M. Cacicedo, Chloe Habib, Nestor Sainz-Rueda, Leah Persky, Patrick G. Sullivan, Barbara E. Corkey, Caroline M. Apovian, Philip A. Kern, Douglas A. Lauffenburger, Barbara S. Nikolajczyk, 2019, Cell Metabolism on p. 447-461.e5
β-Methylamino-L-alanine substitution of serine in SOD1 suggests a direct role in ALS etiology
Elizabeth A. Proctor, David D. Mowrey, Nikolay V. Dokholyan, 2019, PLoS Computational Biology
Most-Cited Papers
Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation
Leena P. Bharath, Madhur Agrawal, Grace McCambridge, Dequina A. Nicholas, Hatice Hasturk, Jing Liu, Kai Jiang, Rui Liu, Zhenheng Guo, Jude Deeney, Caroline M. Apovian, Jennifer Snyder-Cappione, Gregory S. Hawk, Rebecca M. Fleeman, Riley M.F. Pihl, Katherine Thompson, Anna C. Belkina, Licong Cui, Elizabeth A. Proctor, Philip A. Kern, Barbara S. Nikolajczyk, 2020, Cell Metabolism on p. 44-55.e6
Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis
Elizabeth A. Proctor, Lanette Fee, Yazhong Tao, Rachel L. Redler, James M. Fay, Yuliang Zhang, Zhengjian Lv, Ian P. Mercer, Mohanish Deshmukh, Yuri L. Lyubchenko, Nikolay V. Dokholyan, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 614-619
Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes
Dequina A. Nicholas, Elizabeth A. Proctor, Madhur Agrawal, Anna C. Belkina, Stephen C. Van Nostrand, Leena Panneerseelan-Bharath, Albert R. Jones, Forum Raval, Blanche C. Ip, Min Zhu, Jose M. Cacicedo, Chloe Habib, Nestor Sainz-Rueda, Leah Persky, Patrick G. Sullivan, Barbara E. Corkey, Caroline M. Apovian, Philip A. Kern, Douglas A. Lauffenburger, Barbara S. Nikolajczyk, 2019, Cell Metabolism on p. 447-461.e5
Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening
Levi B. Wood, Ashley R. Winslow, Elizabeth A. Proctor, Declan McGuone, Daniel A. Mordes, Matthew P. Frosch, Bradley T. Hyman, Douglas A. Lauffenburger, Kevin M. Haigis, 2015, Scientific Reports
Rational coupled dynamics network manipulation rescues disease-relevant mutant cystic fibrosis transmembrane conductance regulator
Elizabeth A. Proctor, Pradeep Kota, Andrei A. Aleksandrov, Lihua He, John R. Riordan, Nikolay V. Dokholyan, 2015, Chemical Science on p. 1237-1246
Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis
Dequina Nicholas, Elizabeth A. Proctor, Forum M. Raval, Blanche C. Ip, Chloe Habib, Eleni Ritou, Tom N. Grammatopoulos, Devin Steenkamp, Hans Dooms, Caroline M. Apovian, Douglas A. Lauffenburger, Barbara S. Nikolajczyk, 2017, PLoS One
Applications of Discrete Molecular Dynamics in biology and medicine
Elizabeth A. Proctor, Nikolay V. Dokholyan, 2016, Current Opinion in Structural Biology on p. 9-13
Cu,Zn-superoxide dismutase without Zn is folded but catalytically inactive
Sean Nedd, Rachel L. Redler, Elizabeth A. Proctor, Nikolay V. Dokholyan, Anastassia N. Alexandrova, 2014, Journal of Molecular Biology on p. 4112-4124
Computational approaches to understanding protein aggregation in neurodegeneration
Rachel L. Redler, David Shirvanyants, Onur Dagliyan, Feng Ding, Doo Nam Kim, Pradeep Kota, Elizabeth A. Proctor, Srinivas Ramachandran, Arpit Tandon, Nikolay V. Dokholyan, 2014, Journal of Molecular Cell Biology on p. 104-115
Genital-systemic chemokine gradients and the risk of HIV acquisition in women
Lenine J.P. Liebenberg, Lindi Masson, Kelly B. Arnold, Lyle R. McKinnon, Lise Werner, Elizabeth Proctor, Derseree Archary, Leila E. Mansoor, Douglas A. Lauffenburger, Quarraisha Abdool Karim, Salim S.Abdool Karim, Jo Ann S. Passmore, 2017, Journal of Acquired Immune Deficiency Syndromes on p. 318-325