Elizabeth Proctor

Assistant Professor of Neurosurgery, Pharmacology, Biomedical Engineering, and Engineering Science & Mechanics

Elizabeth Proctor

Research Summary

Systems biology of complex disease. Integration of heterogeneous data types across length scales.

Huck Affiliations

Links

Publication Tags

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Proteins Hemodynamics Sleep Cytokines Alzheimer Disease Inflammation Membranes Neurons Amyotrophic Lateral Sclerosis Brain Neurovascular Coupling Autophagy Protein Molecular Dynamics Simulation Hemodynamic Metformin Mutation T Lymphocytes Lymphocytes Energy Metabolism Cells Peptides Pathology Type 2 Diabetes Mellitus Bacteria

Most Recent Publications

Apolipoprotein E ε4 modulates astrocyte neuronal support functions in the presence of amyloid-β

Rebecca M. Fleeman, Madison K. Kuhn, Dennis C. Chan, Elizabeth A. Proctor, 2023, Journal of Neurochemistry on p. 536-549

Predictive link between systemic metabolism and cytokine signatures in the brain of apolipoprotein E ε4 mice

Rebecca Fleeman, A Snyder, M Kuhn, D Chan, G Smith, Nicole Crowley, Amy Arnold, Elizabeth Proctor, 2022, Neurobiology of Aging on p. 154-169

Monosialotetrahexosylganglioside Promotes Early Aβ42 Oligomer Formation and Maintenance

D Zhang, J Wang, R Fleeman, M Kuhn, Matthew T. Swulius, Elizabeth Proctor, Nikolay V. Dokholyan, 2022, ACS Chemical Neuroscience on p. 1979-1991

Astrocytic Propagation of Tau in the Context of Alzheimer's Disease

Rebecca M. Fleeman, Elizabeth A. Proctor, 2021, Frontiers in Cellular Neuroscience

Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry

Andrew Simonson^, Andrew W. Simonson, A Mongia, Agustey Mongia^, Matthew R. Aronson, Agustey S. Mongia, M Aronson, Matthew Aronson^, John N. Alumasa, Dennis Chan, Adam Bolotsky, Atip Lawanprasert^, A Lawanprasert, Michael Howe, Aida Ebrahimi, Elizabeth Proctor, Adam Bolotsky, T. Mal, Kenneth C. Keiler, Scott H. Medina, Christy George, S Ebrahimi, A Ebrahimi, A Baughn, Elizabeth Proctor, Kenneth Keiler, Scott Medina*, S Medina, 2020, Nature Biomedical Engineering on p. 467-480

Neurovascular coupling and bilateral connectivity during nrem and rem sleep

Kevin L. Turner, Kyle W. Gheres, Elizabeth A. Proctor, Patrick J. Drew, 2020, eLife on p. 1

Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model

Elizabeth A. Proctor, Shauna M. Dineen, Stephen C. Van Nostrand, Madison K. Kuhn, Christopher D. Barrett, Douglas K. Brubaker, Michael B. Yaffe, Douglas A. Lauffenburger, Lisa R. Leon, 2020, Journal of Thrombosis and Haemostasis on p. 1900-1910

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

Leena P. Bharath, Madhur Agrawal, Grace McCambridge, Dequina A. Nicholas, Hatice Hasturk, Jing Liu, Kai Jiang, Rui Liu, Zhenheng Guo, Jude Deeney, Caroline M. Apovian, Jennifer Snyder-Cappione, Gregory S. Hawk, Rebecca M. Fleeman, Riley M.F. Pihl, Katherine Thompson, Anna C. Belkina, Licong Cui, Elizabeth A. Proctor, Philip A. Kern, Barbara S. Nikolajczyk, 2020, Cell Metabolism on p. 44-55.e6

A non-local model of the propagation of action potentials in myelinated neurons

Corina S. Drapaca, Sahin Ozdemir, Elizabeth A. Proctor, 2020, Emerging Science Journal on p. 148-164

HFE gene expression impacts sex-based survival in glioblastoma

D Nesterova, V. Midya, B Zacharia, Elizabeth Proctor, S. Lee, L. Stetson, J Lathia, J Rubin, K Waite, M Berens, J Barnholtz-Sloan, J Connor, 2020, Neuro-Oncology Advances on p. vddaa001

Most-Cited Papers

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

Leena P. Bharath, Madhur Agrawal, Grace McCambridge, Dequina A. Nicholas, Hatice Hasturk, Jing Liu, Kai Jiang, Rui Liu, Zhenheng Guo, Jude Deeney, Caroline M. Apovian, Jennifer Snyder-Cappione, Gregory S. Hawk, Rebecca M. Fleeman, Riley M.F. Pihl, Katherine Thompson, Anna C. Belkina, Licong Cui, Elizabeth A. Proctor, Philip A. Kern, Barbara S. Nikolajczyk, 2020, Cell Metabolism on p. 44-55.e6

Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis

Elizabeth A. Proctor, Lanette Fee, Yazhong Tao, Rachel L. Redler, James M. Fay, Yuliang Zhang, Zhengjian Lv, Ian P. Mercer, Mohanish Deshmukh, Yuri L. Lyubchenko, Nikolay V. Dokholyan, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 614-619

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes

Dequina A. Nicholas, Elizabeth A. Proctor, Madhur Agrawal, Anna C. Belkina, Stephen C. Van Nostrand, Leena Panneerseelan-Bharath, Albert R. Jones, Forum Raval, Blanche C. Ip, Min Zhu, Jose M. Cacicedo, Chloe Habib, Nestor Sainz-Rueda, Leah Persky, Patrick G. Sullivan, Barbara E. Corkey, Caroline M. Apovian, Philip A. Kern, Douglas A. Lauffenburger, Barbara S. Nikolajczyk, 2019, Cell Metabolism on p. 447-461.e5

Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis

Dequina Nicholas, Elizabeth A. Proctor, Forum M. Raval, Blanche C. Ip, Chloe Habib, Eleni Ritou, Tom N. Grammatopoulos, Devin Steenkamp, Hans Dooms, Caroline M. Apovian, Douglas A. Lauffenburger, Barbara S. Nikolajczyk, 2017, PLoS One

Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening

Levi B. Wood, Ashley R. Winslow, Elizabeth A. Proctor, Declan McGuone, Daniel A. Mordes, Matthew P. Frosch, Bradley T. Hyman, Douglas A. Lauffenburger, Kevin M. Haigis, 2015, Scientific Reports

Applications of Discrete Molecular Dynamics in biology and medicine

Elizabeth A. Proctor, Nikolay V. Dokholyan, 2016, Current Opinion in Structural Biology on p. 9-13

Rational coupled dynamics network manipulation rescues disease-relevant mutant cystic fibrosis transmembrane conductance regulator

Elizabeth A. Proctor, Pradeep Kota, Andrei A. Aleksandrov, Lihua He, John R. Riordan, Nikolay V. Dokholyan, 2015, Chemical Science on p. 1237-1246

Cu,Zn-superoxide dismutase without Zn is folded but catalytically inactive

Sean Nedd, Rachel L. Redler, Elizabeth A. Proctor, Nikolay V. Dokholyan, Anastassia N. Alexandrova, 2014, Journal of Molecular Biology on p. 4112-4124

Neurovascular coupling and bilateral connectivity during nrem and rem sleep

Kevin L. Turner, Kyle W. Gheres, Elizabeth A. Proctor, Patrick J. Drew, 2020, eLife on p. 1

Computational approaches to understanding protein aggregation in neurodegeneration

Rachel L. Redler, David Shirvanyants, Onur Dagliyan, Feng Ding, Doo Nam Kim, Pradeep Kota, Elizabeth A. Proctor, Srinivas Ramachandran, Arpit Tandon, Nikolay V. Dokholyan, 2014, Journal of Molecular Cell Biology on p. 104-115