Elizabeth Proctor

Assistant Professor of Neurosurgery, Pharmacology, Biomedical Engineering, and Engineering Science & Mechanics

Elizabeth Proctor

Research Summary

Systems biology of complex disease. Integration of heterogeneous data types across length scales.

Huck Affiliations

Links

Publication Tags

Proteins Superoxide Dismutase Molecular Dynamics Simulation Amyotrophic Lateral Sclerosis Peptides Protein Binding Cytokines Inflammation Genomics Equations Of Motion Molecular Dynamics T Lymphocytes Superoxide Dismutase 1 Neurons Dimerization Protein Conformation Membrane Proteins Sleep Recombinant Proteins Protein Folding Serine Neurodegenerative Diseases Autophagy Surface Plasmon Resonance Protein Denaturation

Most Recent Papers

Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry

Andrew W. Simonson, Agustey S. Mongia, Matthew R. Aronson, John Alumasa, Dennis C. Chan, Atip Lawanprasert, Michael D. Howe, Adam Bolotsky, Tapas Mal, Christy George, Seyedehaida Ebrahimi, Anthony D. Baughn, Elizabeth A. Proctor, Kenneth Charles Keiler, Scott H. Medina, 2021, Nature Biomedical Engineering

Neurovascular coupling and bilateral connectivity during nrem and rem sleep

Kevin L. Turner, Kyle W. Gheres, Elizabeth A. Proctor, Patrick J. Drew, 2020, eLife on p. 1

Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model

Elizabeth A. Proctor, Shauna M. Dineen, Stephen C. Van Nostrand, Madison K. Kuhn, Christopher D. Barrett, Douglas K. Brubaker, Michael B. Yaffe, Douglas A. Lauffenburger, Lisa R. Leon, 2020, Journal of Thrombosis and Haemostasis on p. 1900-1910

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

Leena P. Bharath, Madhur Agrawal, Grace McCambridge, Dequina A. Nicholas, Hatice Hasturk, Jing Liu, Kai Jiang, Rui Liu, Zhenheng Guo, Jude Deeney, Caroline M. Apovian, Jennifer Snyder-Cappione, Gregory S. Hawk, Rebecca M. Fleeman, Riley M.F. Pihl, Katherine Thompson, Anna C. Belkina, Licong Cui, Elizabeth A. Proctor, Philip A. Kern, Barbara S. Nikolajczyk, 2020, Cell Metabolism on p. 44-55.e6

A non-local model of the propagation of action potentials in myelinated neurons

Corina S. Drapaca, Sahin Ozdemir, Elizabeth A. Proctor, 2020, Emerging Science Journal on p. 148-164

HFE gene expression impacts sex-based survival in glioblastoma

Elizabeth Proctor, V. Midya, B. Zacharia, E. Proctor, S. Lee, L. Stetson, 2020, Neuro-Oncology Advances on p. vddaa001

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes

Dequina A. Nicholas, Elizabeth Anne Proctor, Madhur Agrawal, Anna C. Belkina, Stephen C. Van Nostrand, Leena Panneerseelan-Bharath, Albert R. Jones, Forum Raval, Blanche C. Ip, Min Zhu, Jose M. Cacicedo, Chloe Habib, Nestor Sainz-Rueda, Leah Persky, Patrick G. Sullivan, Barbara E. Corkey, Caroline M. Apovian, Philip A. Kern, Douglas A. Lauffenburger, Barbara S. Nikolajczyk, 2019, Cell Metabolism on p. 447-461.e5

β-Methylamino-L-alanine substitution of serine in SOD1 suggests a direct role in ALS etiology

Elizabeth A. Proctor, David D. Mowrey, Nikolay V. Dokholyan, 2019, PLoS Computational Biology

Computational translation of genomic responses from experimental model systems to humans

Douglas K. Brubaker, Elizabeth A. Proctor, Kevin M. Haigis, Douglas A. Lauffenburger, 2019, PLoS Computational Biology

Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD-1, TIGIT, and TIM-3 in Lymphocytes From Patients With Systemic Sclerosis

Michelle Fleury, Anna C. Belkina, Elizabeth Anne Proctor, Christopher Zammitti, Robert W. Simms, Douglas A. Lauffenburger, Jennifer E. Snyder-Cappione, Robert Lafyatis, Hans Dooms, 2018, Arthritis and Rheumatology on p. 566-577

Most-Cited Papers

Structural and dynamic determinants of protein-peptide recognition

Onur Dagliyan, Elizabeth Anne Proctor, Kevin M. D'Auria, Feng Ding, Nikolay Dokholyan, 2011, Structure with Folding & design on p. 1837-1845

Glutathionylation at Cys-111 induces dissociation of wild type and FALS mutant SOD1 dimers

Rachel L. Redler, Kyle C. Wilcox, Elizabeth A. Proctor, Lanette Fee, Michael Caplow, Nikolay V. Dokholyan, 2011, Biochemistry on p. 7057-7066

Discrete molecular dynamics

Elizabeth A. Proctor, Feng Ding, Nikolay V. Dokholyan, 2011, Wiley Interdisciplinary Reviews: Computational Molecular Science on p. 80-92

Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis

Elizabeth A. Proctor, Lanette Fee, Yazhong Tao, Rachel L. Redler, James M. Fay, Yuliang Zhang, Zhengjian Lv, Ian P. Mercer, Mohanish Deshmukh, Yuri L. Lyubchenko, Nikolay V. Dokholyan, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 614-619

Structural and thermodynamic effects of post-translational modifications in mutant and wild type Cu, Zn superoxide dismutase

Elizabeth Anne Proctor, Feng Ding, Nikolay Dokholyan, 2011, Journal of Molecular Biology on p. 555-567

Rational coupled dynamics network manipulation rescues disease-relevant mutant cystic fibrosis transmembrane conductance regulator

Elizabeth A. Proctor, Pradeep Kota, Andrei A. Aleksandrov, Lihua He, John R. Riordan, Nikolay V. Dokholyan, 2015, Chemical Science on p. 1237-1246

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

Leena P. Bharath, Madhur Agrawal, Grace McCambridge, Dequina A. Nicholas, Hatice Hasturk, Jing Liu, Kai Jiang, Rui Liu, Zhenheng Guo, Jude Deeney, Caroline M. Apovian, Jennifer Snyder-Cappione, Gregory S. Hawk, Rebecca M. Fleeman, Riley M.F. Pihl, Katherine Thompson, Anna C. Belkina, Licong Cui, Elizabeth A. Proctor, Philip A. Kern, Barbara S. Nikolajczyk, 2020, Cell Metabolism on p. 44-55.e6

Cu,Zn-superoxide dismutase without Zn is folded but catalytically inactive

Sean Nedd, Rachel L. Redler, Elizabeth A. Proctor, Nikolay V. Dokholyan, Anastassia N. Alexandrova, 2014, Journal of Molecular Biology on p. 4112-4124

Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening

Levi B. Wood, Ashley R. Winslow, Elizabeth A. Proctor, Declan McGuone, Daniel A. Mordes, Matthew P. Frosch, Bradley T. Hyman, Douglas A. Lauffenburger, Kevin M. Haigis, 2015, Scientific Reports

Discrete molecular dynamics distinguishes nativelike binding poses from decoys in difficult targets

Elizabeth Anne Proctor, Shuangye Yin, Alexander Tropsha, Nikolay Dokholyan, 2012, Biophysical Journal on p. 144-151