Elizabeth Proctor

Assistant Professor of Neurosurgery, Pharmacology, Biomedical Engineering, and Engineering Science & Mechanics

Elizabeth Proctor

Research Summary

Systems biology of complex disease. Integration of heterogeneous data types across length scales.

Huck Affiliations

Links

Publication Tags

Proteins Amyotrophic Lateral Sclerosis Molecular Dynamics Simulation Superoxide Dismutase Mutation Superoxide Dismutase 1 Molecular Dynamics Cytokines Protein Conformation Protein Binding Agglomeration Cystic Fibrosis Transmembrane Conductance Regulator Genomics Equations Of Motion Ligands Lymphocytes Protein Folding Alanine Recombinant Proteins Binding Sites Neurodegenerative Diseases Poisons Surface Plasmon Resonance Serine Protein Denaturation

Most Recent Papers

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes

Dequina A. Nicholas, Elizabeth Anne Proctor, Madhur Agrawal, Anna C. Belkina, Stephen C. Van Nostrand, Leena Panneerseelan-Bharath, Albert R. Jones, Forum Raval, Blanche C. Ip, Min Zhu, Jose M. Cacicedo, Chloe Habib, Nestor Sainz-Rueda, Leah Persky, Patrick G. Sullivan, Barbara E. Corkey, Caroline M. Apovian, Philip A. Kern, Douglas A. Lauffenburger, Barbara S. Nikolajczyk, 2019, Cell Metabolism on p. 447-461.e5

β-Methylamino-L-alanine substitution of serine in SOD1 suggests a direct role in ALS etiology

Elizabeth A. Proctor, David D. Mowrey, Nikolay V. Dokholyan, 2019, PLoS computational biology

Computational translation of genomic responses from experimental model systems to humans

Douglas K. Brubaker, Elizabeth A. Proctor, Kevin M. Haigis, Douglas A. Lauffenburger, 2019, PLoS computational biology

Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD-1, TIGIT, and TIM-3 in Lymphocytes From Patients With Systemic Sclerosis

Michelle Fleury, Anna C. Belkina, Elizabeth Anne Proctor, Christopher Zammitti, Robert W. Simms, Douglas A. Lauffenburger, Jennifer E. Snyder-Cappione, Robert Lafyatis, Hans Dooms, 2018, Arthritis and Rheumatology on p. 566-577

Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging

Anna C. Belkina, Alina Starchenko, Katherine A. Drake, Elizabeth A. Proctor, Riley M.F. Pihl, Alex Olson, Douglas A. Lauffenburger, Nina Lin, Jennifer E. Snyder-Cappione, 2018, Frontiers in immunology

Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator

Chi Wang, Andrei A. Aleksandrov, Zhengrong Yang, Farhad Forouhar, Elizabeth A. Proctor, Pradeep Kota, Jianli An, Anna Kaplan, Netaly Khazanov, Grégory Boël, Brent R. Stockwell, Hanoch Senderowitz, Nikolay V. Dokholyan, John R. Riordan, Christie G. Brouillette, John F. Hunt, 2018, Journal of Biological Chemistry on p. 17685-17704

Genital-systemic chemokine gradients and the risk of HIV acquisition in women

Lenine J.P. Liebenberg, Lindi Masson, Kelly B. Arnold, Lyle R. McKinnon, Lise Werner, Elizabeth Proctor, Derseree Archary, Leila E. Mansoor, Douglas A. Lauffenburger, Quarraisha Abdool Karim, Salim S.Abdool Karim, Jo Ann S. Passmore, 2017, Journal of Acquired Immune Deficiency Syndromes on p. 318-325

Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis

Dequina Nicholas, Elizabeth A. Proctor, Forum M. Raval, Blanche C. Ip, Chloe Habib, Eleni Ritou, Tom N. Grammatopoulos, Devin Steenkamp, Hans Dooms, Caroline M. Apovian, Douglas A. Lauffenburger, Barbara S. Nikolajczyk, 2017, PloS one

A Phosphomimetic Mutation Stabilizes SOD1 and Rescues Cell Viability in the Context of an ALS-Associated Mutation

James M. Fay, Cheng Zhu, Elizabeth A. Proctor, Yazhong Tao, Wenjun Cui, Hengming Ke, Nikolay V. Dokholyan, 2016, Structure on p. 1898-1906

A hidden aggregation-prone structure in the heart of hypoxia inducible factor prolyl hydroxylase

Hamid Hadi-Alijanvand, Elizabeth A. Proctor, Feng Ding, Nikolay V. Dokholyan, Ali A. Moosavi-Movahedi, 2016, Proteins: Structure, Function and Bioinformatics on p. 611-623

Most-Cited Papers

Structural and dynamic determinants of protein-peptide recognition

Onur Dagliyan, Elizabeth Anne Proctor, Kevin M. D'Auria, Feng Ding, Nikolay Dokholyan, 2011, Structure on p. 1837-1845

Glutathionylation at Cys-111 induces dissociation of wild type and FALS mutant SOD1 dimers

Rachel L. Redler, Kyle C. Wilcox, Elizabeth A. Proctor, Lanette Fee, Michael Caplow, Nikolay V. Dokholyan, 2011, Biochemistry on p. 7057-7066

Discrete molecular dynamics

Elizabeth A. Proctor, Feng Ding, Nikolay V. Dokholyan, 2011, Wiley Interdisciplinary Reviews: Computational Molecular Science on p. 80-92

Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis

Elizabeth A. Proctor, Lanette Fee, Yazhong Tao, Rachel L. Redler, James M. Fay, Yuliang Zhang, Zhengjian Lv, Ian P. Mercer, Mohanish Deshmukh, Yuri L. Lyubchenko, Nikolay V. Dokholyan, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 614-619

Structural and thermodynamic effects of post-translational modifications in mutant and wild type Cu, Zn superoxide dismutase

Elizabeth Anne Proctor, Feng Ding, Nikolay Dokholyan, 2011, Journal of Molecular Biology on p. 555-567

Discrete molecular dynamics distinguishes nativelike binding poses from decoys in difficult targets

Elizabeth Anne Proctor, Shuangye Yin, Alexander Tropsha, Nikolay Dokholyan, 2012, Biophysical Journal on p. 144-151

Rational coupled dynamics network manipulation rescues disease-relevant mutant cystic fibrosis transmembrane conductance regulator

Elizabeth A. Proctor, Pradeep Kota, Andrei A. Aleksandrov, Lihua He, John R. Riordan, Nikolay V. Dokholyan, 2015, Chemical Science on p. 1237-1246

Cu,Zn-superoxide dismutase without Zn is folded but catalytically inactive

Sean Nedd, Rachel L. Redler, Elizabeth A. Proctor, Nikolay V. Dokholyan, Anastassia N. Alexandrova, 2014, Journal of Molecular Biology on p. 4112-4124

Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening

Levi B. Wood, Ashley R. Winslow, Elizabeth A. Proctor, Declan McGuone, Daniel A. Mordes, Matthew P. Frosch, Bradley T. Hyman, Douglas A. Lauffenburger, Kevin M. Haigis, 2015, Scientific reports

A Phosphomimetic Mutation Stabilizes SOD1 and Rescues Cell Viability in the Context of an ALS-Associated Mutation

James M. Fay, Cheng Zhu, Elizabeth A. Proctor, Yazhong Tao, Wenjun Cui, Hengming Ke, Nikolay V. Dokholyan, 2016, Structure on p. 1898-1906