Elizabeth Proctor
Associate Professor of Neurosurgery and of Pharmacology
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HCAR 3039
Hershey, PA - exp412@psu.edu
- 717-531-5922
Research Summary
Systems biology of complex disease. Integration of heterogeneous data types across length scales.
Huck Affiliations
- Bioinformatics and Genomics
- Neuroscience Institute
- Center for Neural Engineering
- Center for Neurotechnology in Mental Health Research
Links
Most Recent Publications
Analysis of transition metal content in glioblastoma reveals association between iron and survival
Ganesh Shenoy, Aurosman Sahu, Madison Kuhn, Vladimir Khristov, Madison Heebner, Hannah Wilding, Taylor Clegg, Debarati Bhanja, Quinn Wade, Laura Jean Liermann, Dongxiang Wang, Nataliya Smith, Gabriela Remite-Berthet, Chachrit Khunsriraksakul, Kondaiah Palsa, Becky Slagle-Webb, Seyed Alireza Mansouri, Brad E. Zacharia, Elizabeth A. Proctor, James Connor, 2025, Translational Oncology
Cross-Species Modeling Identifies Gene Signatures in Type 2 Diabetes Mouse Models Predictive of Inflammatory and Estrogen Signaling Pathways Associated with Alzheimer's Disease Outcomes in Humans
Brendan K. Ball, Elizabeth A. Proctor, Douglas K. Brubaker, 2025, Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing on p. 426-440
Alcohol consumption confers lasting impacts on prefrontal cortical neuron intrinsic excitability and spontaneous neurotransmitter signaling in the aging brain in mice
Grace C. Smith, Keith R. Griffith, Avery R. Sicher, Dakota F. Brockway, Elizabeth A. Proctor, Nicole A. Crowley, 2025, Neurobiology of Aging on p. 42-54
Differential responses of primary neuron-secreted MCP-1 and IL-9 to type 2 diabetes and Alzheimer’s disease-associated metabolites
Brendan K. Ball, Madison K. Kuhn, Rebecca M. Fleeman Bechtel, Elizabeth A. Proctor, Douglas K. Brubaker, 2024, Scientific Reports
A common variant in the iron regulatory gene (Hfe) alters the metabolic and transcriptional landscape in brain regions vulnerable to neurodegeneration
Savannah Marshall Moscon, Elizabeth Neely, Elizabeth Anne Proctor, James Connor, 2024, Journal of Neurochemistry on p. 3132-3153
Everolimus alleviates CD4<sup>+</sup> T cell inflammation by regulating autophagy and cellular redox homeostasis
Jack Donato Rockhold, Heather Marszalkowski, Marco Sannella, Kaleigh Gibney, Lyanne Murphy, Emelia Zukowski, Gabriella H. Kalantar, Sara SantaCruz-Calvo, Samantha N. Hart, Madison K. Kuhn, Jingting Yu, Olivia Stefanik, Gabrielle Chase, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath, 2024, GeroScience
Microglial Drivers of Alzheimer's Disease Pathology: An Evolution of Diverse Participating States
Madison K Kuhn, Elizabeth A Proctor, 2024, Proteins: Structure, Function and Genetics
Amyloid-β Pathology-Specific Cytokine Secretion Suppresses Neuronal Mitochondrial Metabolism
Madison K. Kuhn, Rebecca M. Fleeman, Lynne M. Beidler, Amanda Snyder, Dennis C. Chan, Elizabeth A. Proctor, 2023, Cellular and Molecular Bioengineering on p. 405-421
Apolipoprotein E ε4 modulates astrocyte neuronal support functions in the presence of amyloid-β
Rebecca M. Fleeman, Madison K. Kuhn, Dennis C. Chan, Elizabeth A. Proctor, 2023, Journal of Neurochemistry on p. 536-549
STAT3 modulates CD4<sup>+</sup> T mitochondrial dynamics and function in aging
Emelia Zukowski, Marco Sannella, Jack Donato Rockhold, Gabriella H. Kalantar, Jingting Yu, Sara SantaCruz-Calvo, Madison K. Kuhn, Nasun Hah, Ling Ouyang, Tzu Wen Wang, Lyanne Murphy, Heather Marszalkowski, Kaleigh Gibney, Micah J. Drummond, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath, 2023, Aging Cell
Most-Cited Papers
Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation
Leena P. Bharath, Madhur Agrawal, Grace McCambridge, Dequina A. Nicholas, Hatice Hasturk, Jing Liu, Kai Jiang, Rui Liu, Zhenheng Guo, Jude Deeney, Caroline M. Apovian, Jennifer Snyder-Cappione, Gregory S. Hawk, Rebecca M. Fleeman, Riley M.F. Pihl, Katherine Thompson, Anna C. Belkina, Licong Cui, Elizabeth A. Proctor, Philip A. Kern, Barbara S. Nikolajczyk, 2020, Cell Metabolism on p. 44-55.e6
Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes
Dequina A. Nicholas, Elizabeth A. Proctor, Madhur Agrawal, Anna C. Belkina, Stephen C. Van Nostrand, Leena Panneerseelan-Bharath, Albert R. Jones, Forum Raval, Blanche C. Ip, Min Zhu, Jose M. Cacicedo, Chloe Habib, Nestor Sainz-Rueda, Leah Persky, Patrick G. Sullivan, Barbara E. Corkey, Caroline M. Apovian, Philip A. Kern, Douglas A. Lauffenburger, Barbara S. Nikolajczyk, 2019, Cell Metabolism on p. 447-461.e5
Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis
Elizabeth A. Proctor, Lanette Fee, Yazhong Tao, Rachel L. Redler, James M. Fay, Yuliang Zhang, Zhengjian Lv, Ian P. Mercer, Mohanish Deshmukh, Yuri L. Lyubchenko, Nikolay V. Dokholyan, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 614-619
Neurovascular coupling and bilateral connectivity during nrem and rem sleep
Kevin L. Turner, Kyle W. Gheres, Elizabeth A. Proctor, Patrick J. Drew, 2020, eLife on p. 1
Applications of Discrete Molecular Dynamics in biology and medicine
Elizabeth A. Proctor, Nikolay V. Dokholyan, 2016, Current Opinion in Structural Biology on p. 9-13
Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening
Levi B. Wood, Ashley R. Winslow, Elizabeth A. Proctor, Declan McGuone, Daniel A. Mordes, Matthew P. Frosch, Bradley T. Hyman, Douglas A. Lauffenburger, Kevin M. Haigis, 2015, Scientific Reports
Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis
Dequina Nicholas, Elizabeth A. Proctor, Forum M. Raval, Blanche C. Ip, Chloe Habib, Eleni Ritou, Tom N. Grammatopoulos, Devin Steenkamp, Hans Dooms, Caroline M. Apovian, Douglas A. Lauffenburger, Barbara S. Nikolajczyk, 2017, PLoS One
Astrocytic Propagation of Tau in the Context of Alzheimer's Disease
Rebecca M. Fleeman, Elizabeth A. Proctor, 2021, Frontiers in Cellular Neuroscience
Rational coupled dynamics network manipulation rescues disease-relevant mutant cystic fibrosis transmembrane conductance regulator
Elizabeth A. Proctor, Pradeep Kota, Andrei A. Aleksandrov, Lihua He, John R. Riordan, Nikolay V. Dokholyan, 2015, Chemical Science on p. 1237-1246
A Phosphomimetic Mutation Stabilizes SOD1 and Rescues Cell Viability in the Context of an ALS-Associated Mutation
James M. Fay, Cheng Zhu, Elizabeth A. Proctor, Yazhong Tao, Wenjun Cui, Hengming Ke, Nikolay V. Dokholyan, 2016, Structure with Folding & design on p. 1898-1906
News Articles Featuring Elizabeth Proctor
Nov 19, 2024
Early adult binge drinking has lasting impact on aging brain in mice
Binge drinking in early adults can lead to long-lasting and potentially permanent dysregulation in the brain, according to a new study in mice, led by researchers at Penn State.
Full Article
Aug 25, 2022
Penn State awarded $1.6M to study if COVID-19 contributes to cognitive decline
As populations around the globe age, dementia — often caused by Alzheimer’s disease and related disorders — is a growing health issue for older adults worldwide.
Full Article
Sep 17, 2019
Research suggests how environmental toxin produced by algae may lead to ALS
Can a computer be used to explain why an environmental toxin might lead to neurodegenerative disease? According to Penn State College of Medicine researchers, a computer generated-simulation allowed them to see how a toxin produced by algal blooms in saltwater might cause Amyotrophic Lateral Sclerosis (ALS).
Full Article