Christian Huber

Assistant Professor of Biology

Christian Huber

Research Summary

How evolutionary mechanisms such as mutation, recombination, and natural selection shape genetic diversity and the variability between individuals and species.

Huck Graduate Students

Huck Affiliations

Links

Most Recent Publications

A likelihood-based framework for demographic inference from genealogical trees

Caoqi Fan, Jordan L. Cahoon, Bryan L. Dinh, Diego Ortega-Del Vecchyo, Christian D. Huber, Michael D. Edge, Nicholas Mancuso, Charleston W.K. Chiang, 2025, Nature Genetics on p. 865-874

Testing times: Disentangling admixture histories in recent and complex demographies using ancient DNA

Matthew P. Williams, Pavel Flegontov, Robert Maier, Christian D. Huber, 2024, Genetics

The complete sequence and comparative analysis of ape sex chromosomes

Kateryna D. Makova, Brandon Pickett, R Harris, Gabrielle Hartley, Monika Cechova, Karol Pal, Sergey Nurk, DongAhn Yoo, Qiuhui Li, Prajna Hebbar, B McGrath, Francesca Antonacci, Margaux Aubel, Arjun Biddanda, Matthew Borchers, Erich Bornberg-Bauer, Gerard Bouffard, Shelise Brooks, Lucia Carbone, Laura Carrel, Andrew Carroll, Pi-Chuan Chang, Chen-Shan Chin, Daniel Cook, S Craig, Luciana de Gennaro, Mark Diekhans, Amalia Dutra, Gage Garcia, Patrick Grady, Richard Green, Diana Haddad, Pille Hallast, William Harvey, Glenn Hickey, David Hillis, Savannah Hoyt, Hyeonsoo Jeong, Kaivan Kamali, Sergei Pond, Troy LaPolice, Charles Lee, Alexandra Lewis, Yong-Hwee Loh, Patrick Masterson, Kelly McGarvey, Rajiv McCoy, P Medvedev, Karen Miga, Katherine Munson, Evgenia Pak, Benedict Paten, Brendan Pinto, Tamara Potapova, Arang Rhie, Joana Rocha, Fedor Ryabov, Oliver Ryder, Samuel Sacco, Kishwar Shafin, Valery Shepelev, Viviane Slon, Steven Solar, Jessica Storer, Peter Sudmant, Sweetalana, Sweetalana, Alex Sweeten, Michael Tassia, Françoise Thibaud-Nissen, Thibaud-Nissen, Fran\ccoise, Mario Ventura, Melissa Wilson, Alice Young, Huiqing Zeng, Xinru Zhang, Z Szpiech, Christian D. Huber, Jennifer Gerton, Soojin Yi, Michael Schatz, Ivan Alexandrov, Sergey Koren, Rachel J. O’Neill, Rachel O'Neill, Evan Eichler, Adam Phillippy, 2024, Nature on p. 410-411

Population genetic simulation: Benchmarking frameworks for non-standard models of natural selection

Olivia L. Johnson, Raymond Tobler, Joshua M. Schmidt, Christian D. Huber, 2024, Molecular Ecology Notes

The Promise of Inferring the Past Using the Ancestral Recombination Graph

Debora Y.C. Brandt, Christian D. Huber, Charleston W.K. Chiang, Diego Ortega Del Vecchyo, 2024, Genome Biology and Evolution

The role of genetic selection and climatic factors in the dispersal of anatomically modern humans out of Africa

Raymond Tobler, Yassine Souilmi, Christian D. Huber, Nigel Bean, Chris S.M. Turney, Shane T. Grey, Alan Cooper, 2023, Proceedings of the National Academy of Sciences of the United States of America on p. e2213061120

Standing genetic variation fuels rapid evolution of herbicide resistance in blackgrass

Sonja Kersten, Jiyang Chang, Christian D. Huber, Yoav Voichek, Christa Lanz, Timo Hagmaier, Patricia Lang, Ulrich Lutz, Insa Hirschberg, Jens Lerchl, Aimone Porri, Yves Van de Peer, Karl Schmid, Detlef Weigel, Fernando A. Rabanal, 2023, Proceedings of the National Academy of Sciences of the United States of America

Fluctuating selection and the determinants of genetic variation

Olivia Johnson, Raymond Tobler, Joshua Schmidt, Christian Huber, 2023, Trends in Genetics on p. 491-504

CATE: A fast and scalable CUDA implementation to conduct highly parallelized evolutionary tests on large scale genomic data

Deshan Perera, Elsa Reisenhofer, Said Hussein, Eve Higgins, Christian D. Huber, Quan Long, 2023, Methods in Ecology and Evolution on p. 2095-2109

Admixture has obscured signals of historical hard sweeps in humans

Yassine Souilmi, Raymond Tobler, Angad Johar, Matthew Williams, Shane Grey, Joshua Schmidt, Joao Teixeira, Adam Rohrlach, Jonathan Tuke, Olivia Johnson, Graham Gower, Chris Turney, Murray Cox, Alan Cooper, Christian D. Huber, 2022, Nature Ecology and Evolution on p. 2003-2015

Most-Cited Papers

The inflated significance of neutral genetic diversity in conservation genetics

João C. Teixeira, Christian D. Huber, 2021, Proceedings of the National Academy of Sciences of the United States of America

SweepFinder2: Increased sensitivity, robustness and flexibility

M DeGiorgio, Christian Huber, Melissa Hubisz, Ines Hellmann, Rasmus Nielsen, 2016, Bioinformatics on p. 1895--1897

Inference of the distribution of selection coefficients for new nonsynonymous mutations using large samples

Bernard Y. Kim, Christian D. Huber, Kirk E. Lohmueller, 2017, Genetics on p. 345-361

Detecting recent selective sweeps while controlling for mutation rate and background selection

Christian Huber, M DeGiorgio, Ines Hellmann, Rasmus Nielsen, 2016, Molecular Ecology on p. 142--156

Determining the factors driving selective effects of new nonsynonymous mutations

Christian D. Huber, Bernard Y. Kim, Clare D. Marsden, Kirk E. Lohmueller, 2017, Proceedings of the National Academy of Sciences of the United States of America on p. 4465-4470

Deleterious variation shapes the genomic landscape of introgression

Bernard Y. Kim, Christian D. Huber, Kirk E. Lohmueller, 2018, PLoS Genetics

Gene expression drives the evolution of dominance

Christian D. Huber, Arun Durvasula, Angela M. Hancock, Kirk E. Lohmueller, 2018, Nature Communications

Population genetic models of GERP scores suggest pervasive turnover of constrained sites across mammalian evolution

Christian D. Huber, Bernard Y. Kim, Kirk E. Lohmueller, 2020, PLoS Genetics

An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia

Yassine Souilmi, M. Elise Lauterbur, Ray Tobler, Christian D. Huber, Angad S. Johar, Shayli Varasteh Moradi, Wayne A. Johnston, Nevan J. Krogan, Kirill Alexandrov, David Enard, 2021, Current Biology on p. 3504-3514.e9

Understanding the Hidden Complexity of Latin American Population Isolates

Jazlyn A. Mooney, Christian D. Huber, Susan Service, Jae Hoon Sul, Clare D. Marsden, Zhongyang Zhang, Chiara Sabatti, Andrés Ruiz-Linares, Gabriel Bedoya, Scott C. Fears, Susan K. Service, Barbara Kremeyer, Carmen Araya Lic, Xinia Araya Lic, Julio Bejarano, Margarita Ramirez Lic, Gabriel Castrillón, Maria C. Lopez, Gabriel Montoya, Patricia Montoya, Terri M. Teshiba, Lori Altshuler, George Bartzokis, Javier Escobar, Jorge Ospina-Duque, Neil Risch, Andrés Ruiz-Linares, Rita M. Cantor, Carlos Lopez-Jaramillo, Gabriel Macaya, Julio Molina, Victor I. Reus, Chiara Sabatti, Nelson B. Freimer, Carrie E. Bearden, Jae Hoon Sul, Alden Y. Huang, Vasily Ramensky, Sun Goo Hwang, Young Jun Park, Zhongyang Zhang, Loes M. Olde Loohuis, Mitzi Spesny, Juliana Gomez-Makhinson, Gabriel Bedoya, Giovanni Coppola, Nelson Freimer, Kirk E. Lohmueller, 2018, American Journal of Human Genetics on p. 707-726

News Articles Featuring Christian Huber

Apr 09, 2025

Complete genome sequences of six ape species unveiled

Differences among the DNA of seven ape species — including humans — are greater than originally thought, according to an international team led by researchers at Penn State, the National Human Genome Research Institute, and the University of Washington.

Full Article

Apr 09, 2025

Complete genome sequences of six ape species unveiled

Previously inaccessible regions reveal novel insights that may advance understanding of evolution and conservation genetics for endangered apes as well as human health.

Full Article

May 29, 2024

Complete X and Y chromosome sequences of living great ape species determined

Newly generated, complete “end-to-end” reference genomes for the sex chromosomes of five great ape species and one lesser ape species — produced by an international collaborative team led by researchers at Penn State, the National Human Genome Research Institute and the University of Washington — highlight extremely rapid changes on the male-specific Y chromosome among ape species.

Full Article

Nov 02, 2022

Ancient genomes reveal hidden history of human adaptation

It is widely believed that the genetics of our human ancestors did not change in response to environmental pressures as much as that of other animals. However, a new study comparing modern human genomes with ancient human DNA finds that certain genetic changes in humans may have been more common than previously thought.

Full Article