Christian Huber

Assistant Professor of Biology

Research Summary

How evolutionary mechanisms such as mutation, recombination, and natural selection shape genetic diversity and the variability between individuals and species.

Huck Graduate Students

Troy LaPolice

Huck Affiliations

Bioinformatics and Genomics

Publication Tags

These publication tags are generated from the output of this researcher. Click any tag below to view other Huck researchers working on the same topic.

Mutation Population Genes Genomics Genome Drosophila Melanogaster Genetic Variation Mutation Rate Viruses Proteins Protein Ancestry Pressure Demography Fitness Rate Hepatitis Coronavirus East Asia Gene Expression Virus Far East Coronavirinae Principal Component Analysis Flexibility

Most Recent Publications

Admixture has obscured signals of historical hard sweeps in humans

Yassine Souilmi, Raymond Tobler, Angad Johar, Matthew Williams, Shane Grey, Joshua Schmidt, Joao Teixeira, Adam Rohrlach, Jonathan Tuke, Olivia Johnson, Graham Gower, Chris Turney, Murray Cox, Alan Cooper, Christian D. Huber, 2022, Nature Ecology and Evolution on p. 2003-2015

smartsnp, an r package for fast multivariate analyses of big genomic data

Salvador Herrando-Pérez, Raymond Tobler, Christian D. Huber, 2021, Methods in Ecology and Evolution on p. 2084-2093

The biasing impact of irrelevant contextual information on forensic odontology radiograph matching decisions

Sher Lin Chiam, Itiel E. Dror, Christian D. Huber, Denice Higgins, 2021, Forensic Science International

Erratum: “An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia” (Current Biology (2021) 31(16) (3504–3514.e9), (S0960982221007946), (10.1016/j.cub.2021.05.067))

Yassine Souilmi, M. Elise Lauterbur, Ray Tobler, Christian D. Huber, Angad S. Johar, Shayli Varasteh Moradi, Wayne A. Johnston, Nevan J. Krogan, Kirill Alexandrov, David Enard, 2021, Current Biology on p. 3704

An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia

Authors’ Reply to Letter to the Editor: Neutral genetic diversity as a useful tool for conservation biology

João C. Teixeira, Christian D. Huber, 2021, Conservation Genetics on p. 547-549

The inflated significance of neutral genetic diversity in conservation genetics

João C. Teixeira, Christian D. Huber, 2021, Proceedings of the National Academy of Sciences of the United States of America

Standing genetic variation fuels rapid evolution of herbicide resistance in blackgrass

Sonja Kersten, Jiyang Chang, Christian Huber, Yoav Voichek, Christa Lanz, Timo Hagmaier, 2021, bioRxiv

Genetic and climatic factors in the dispersal of Anatomically Modern Humans Out of Africa

Raymond Tobler, Yassine Souilmi, Christian Huber, Nigel Bean, Chris Turney, Alan Cooper, Shane Grey, 2021, Research Square

Quantifying the evolutionary constraints and potential of hepatitis c virus ns5a protein

Lei Dai, Yushen Du, Hangfei Qi, Christian D. Huber, Dongdong Chen, Tian Hao Zhang, Nicholas C. Wu, Ergang Wang, James O. Lloyd-Smith, Ren Sun, 2021, mSystems

Most-Cited Papers

Massive genomic variation and strong selection in Arabidopsis thaliana lines from Sweden

Quan Long, Fernando A. Rabanal, Dazhe Meng, Christian D. Huber, Ashley Farlow, Alexander Platzer, Qingrun Zhang, Bjarni J. Vilhjálmsson, Arthur Korte, Viktoria Nizhynska, Viktor Voronin, Pamela Korte, Laura Sedman, Terezie Mandáková, Martin A. Lysak, Ümit Seren, Ines Hellmann, Magnus Nordborg, 2013, Nature Genetics on p. 884-890

SweepFinder2: Increased sensitivity, robustness and flexibility

M DeGiorgio, Christian Huber, Melissa Hubisz, Ines Hellmann, Rasmus Nielsen, 2016, Bioinformatics on p. 1895--1897

The inflated significance of neutral genetic diversity in conservation genetics

João C. Teixeira, Christian D. Huber, 2021, Proceedings of the National Academy of Sciences of the United States of America

Detecting recent selective sweeps while controlling for mutation rate and background selection

Christian Huber, M DeGiorgio, Ines Hellmann, Rasmus Nielsen, 2016, Molecular Ecology on p. 142--156

Inference of the distribution of selection coefficients for new nonsynonymous mutations using large samples

Bernard Y. Kim, Christian D. Huber, Kirk E. Lohmueller, 2017, Genetics on p. 345-361

Variation in thermal performance and reaction norms among populations of drosophila melanogaster

Peter Klepsatel, Martina Gáliková, Nicola De Maio, Christian D. Huber, Christian Schlötterer, Thomas Flatt, 2013, Evolution; international journal of organic evolution on p. 3573-3587

Determining the factors driving selective effects of new nonsynonymous mutations

Christian D. Huber, Bernard Y. Kim, Clare D. Marsden, Kirk E. Lohmueller, 2017, Proceedings of the National Academy of Sciences of the United States of America on p. 4465-4470

Similarities and differences in altitudinal versus latitudinal variation for morphological traits in drosophila melanogaster

Peter Klepsatel, Martina Gáliková, Christian D. Huber, Thomas Flatt, 2014, Evolution; international journal of organic evolution on p. 1385-1398

Gene expression drives the evolution of dominance

Christian D. Huber, Arun Durvasula, Angela M. Hancock, Kirk E. Lohmueller, 2018, Nature Communications

Deleterious variation shapes the genomic landscape of introgression

Bernard Y. Kim, Christian D. Huber, Kirk E. Lohmueller, 2018, PLoS Genetics

News Articles Featuring Christian Huber

Nov 02, 2022

Ancient genomes reveal hidden history of human adaptation

It is widely believed that the genetics of our human ancestors did not change in response to environmental pressures as much as that of other animals. However, a new study comparing modern human genomes with ancient human DNA finds that certain genetic changes in humans may have been more common than previously thought.

Full Article