Christian Huber
Assistant Professor of Biology

- He/Him/His
- cdh5313@psu.edu
- 814-863-6634
Research Summary
How evolutionary mechanisms such as mutation, recombination, and natural selection shape genetic diversity and the variability between individuals and species.
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Mutation Population Genes Genomics Genome Drosophila Melanogaster Genetic Variation Mutation Rate Viruses Proteins Protein Ancestry Pressure Demography Fitness Rate Hepatitis Coronavirus East Asia Gene Expression Virus Far East Coronavirinae Principal Component Analysis FlexibilityMost Recent Publications
Admixture has obscured signals of historical hard sweeps in humans
Yassine Souilmi, Raymond Tobler, Angad Johar, Matthew Williams, Shane Grey, Joshua Schmidt, Joao Teixeira, Adam Rohrlach, Jonathan Tuke, Olivia Johnson, Graham Gower, Chris Turney, Murray Cox, Alan Cooper, Christian D. Huber, 2022, Nature Ecology and Evolution on p. 2003-2015
smartsnp, an r package for fast multivariate analyses of big genomic data
Salvador Herrando-Pérez, Raymond Tobler, Christian D. Huber, 2021, Methods in Ecology and Evolution on p. 2084-2093
The biasing impact of irrelevant contextual information on forensic odontology radiograph matching decisions
Sher Lin Chiam, Itiel E. Dror, Christian D. Huber, Denice Higgins, 2021, Forensic Science International
Erratum: “An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia” (Current Biology (2021) 31(16) (3504–3514.e9), (S0960982221007946), (10.1016/j.cub.2021.05.067))
Yassine Souilmi, M. Elise Lauterbur, Ray Tobler, Christian D. Huber, Angad S. Johar, Shayli Varasteh Moradi, Wayne A. Johnston, Nevan J. Krogan, Kirill Alexandrov, David Enard, 2021, Current Biology on p. 3704
An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia
Yassine Souilmi, M. Elise Lauterbur, Ray Tobler, Christian D. Huber, Angad S. Johar, Shayli Varasteh Moradi, Wayne A. Johnston, Nevan J. Krogan, Kirill Alexandrov, David Enard, 2021, Current Biology on p. 3504-3514.e9
Authors’ Reply to Letter to the Editor: Neutral genetic diversity as a useful tool for conservation biology
João C. Teixeira, Christian D. Huber, 2021, Conservation Genetics on p. 547-549
The inflated significance of neutral genetic diversity in conservation genetics
João C. Teixeira, Christian D. Huber, 2021, Proceedings of the National Academy of Sciences of the United States of America
Standing genetic variation fuels rapid evolution of herbicide resistance in blackgrass
Sonja Kersten, Jiyang Chang, Christian Huber, Yoav Voichek, Christa Lanz, Timo Hagmaier, 2021, bioRxiv
Genetic and climatic factors in the dispersal of Anatomically Modern Humans Out of Africa
Raymond Tobler, Yassine Souilmi, Christian Huber, Nigel Bean, Chris Turney, Alan Cooper, Shane Grey, 2021, Research Square
Quantifying the evolutionary constraints and potential of hepatitis c virus ns5a protein
Lei Dai, Yushen Du, Hangfei Qi, Christian D. Huber, Dongdong Chen, Tian Hao Zhang, Nicholas C. Wu, Ergang Wang, James O. Lloyd-Smith, Ren Sun, 2021, mSystems
Most-Cited Papers
Massive genomic variation and strong selection in Arabidopsis thaliana lines from Sweden
Quan Long, Fernando A. Rabanal, Dazhe Meng, Christian D. Huber, Ashley Farlow, Alexander Platzer, Qingrun Zhang, Bjarni J. Vilhjálmsson, Arthur Korte, Viktoria Nizhynska, Viktor Voronin, Pamela Korte, Laura Sedman, Terezie Mandáková, Martin A. Lysak, Ümit Seren, Ines Hellmann, Magnus Nordborg, 2013, Nature Genetics on p. 884-890
SweepFinder2: Increased sensitivity, robustness and flexibility
M DeGiorgio, Christian Huber, Melissa Hubisz, Ines Hellmann, Rasmus Nielsen, 2016, Bioinformatics on p. 1895--1897
The inflated significance of neutral genetic diversity in conservation genetics
João C. Teixeira, Christian D. Huber, 2021, Proceedings of the National Academy of Sciences of the United States of America
Detecting recent selective sweeps while controlling for mutation rate and background selection
Christian Huber, M DeGiorgio, Ines Hellmann, Rasmus Nielsen, 2016, Molecular Ecology on p. 142--156
Inference of the distribution of selection coefficients for new nonsynonymous mutations using large samples
Bernard Y. Kim, Christian D. Huber, Kirk E. Lohmueller, 2017, Genetics on p. 345-361
Variation in thermal performance and reaction norms among populations of drosophila melanogaster
Peter Klepsatel, Martina Gáliková, Nicola De Maio, Christian D. Huber, Christian Schlötterer, Thomas Flatt, 2013, Evolution; international journal of organic evolution on p. 3573-3587
Determining the factors driving selective effects of new nonsynonymous mutations
Christian D. Huber, Bernard Y. Kim, Clare D. Marsden, Kirk E. Lohmueller, 2017, Proceedings of the National Academy of Sciences of the United States of America on p. 4465-4470
Similarities and differences in altitudinal versus latitudinal variation for morphological traits in drosophila melanogaster
Peter Klepsatel, Martina Gáliková, Christian D. Huber, Thomas Flatt, 2014, Evolution; international journal of organic evolution on p. 1385-1398
Gene expression drives the evolution of dominance
Christian D. Huber, Arun Durvasula, Angela M. Hancock, Kirk E. Lohmueller, 2018, Nature Communications
Deleterious variation shapes the genomic landscape of introgression
Bernard Y. Kim, Christian D. Huber, Kirk E. Lohmueller, 2018, PLoS Genetics