Christian Huber
Assistant Professor of Biology
- He/Him/His
- cdh5313@psu.edu
- 814-863-6634
Research Summary
How evolutionary mechanisms such as mutation, recombination, and natural selection shape genetic diversity and the variability between individuals and species.
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Mutation Population Genes Genomics Genome Drosophila Melanogaster Mutation Rate Genetic Variation Ancestry East Asia Flexibility Gene Expression Coronavirinae Far East Epidemics Principal Component Analysis Coronavirus Introgression Rate Demography Genetic Recombination Gene Flow Pressure Biological Sciences PhenotypeMost Recent Publications
CATE: A fast and scalable CUDA implementation to conduct highly parallelized evolutionary tests on large scale genomic data
Deshan Perera, Elsa Reisenhofer, Said Hussein, Eve Higgins, Christian D. Huber, Quan Long, 2023, Methods in Ecology and Evolution on p. 2095-2109
Fluctuating selection and the determinants of genetic variation
Olivia L. Johnson, Raymond Tobler, Joshua M. Schmidt, Christian D. Huber, 2023, Trends in Genetics on p. 491-504
The role of genetic selection and climatic factors in the dispersal of anatomically modern humans out of Africa
Raymond Tobler, Yassine Souilmi, Christian D. Huber, Nigel Bean, Chris S.M. Turney, Shane T. Grey, Alan Cooper, 2023, Proceedings of the National Academy of Sciences of the United States of America on p. e2213061120
Standing genetic variation fuels rapid evolution of herbicide resistance in blackgrass
Sonja Kersten, Jiyang Chang, Christian D. Huber, Yoav Voichek, Christa Lanz, Timo Hagmaier, Patricia Lang, Ulrich Lutz, Insa Hirschberg, Jens Lerchl, Aimone Porri, Yves Van de Peer, Karl Schmid, Detlef Weigel, Fernando A. Rabanal, 2023, Proceedings of the National Academy of Sciences of the United States of America
Admixture has obscured signals of historical hard sweeps in humans
Yassine Souilmi, Raymond Tobler, Angad Johar, Matthew Williams, Shane Grey, Joshua Schmidt, Joao Teixeira, Adam Rohrlach, Jonathan Tuke, Olivia Johnson, Graham Gower, Chris Turney, Murray Cox, Alan Cooper, Christian D. Huber, 2022, Nature Ecology and Evolution on p. 2003-2015
smartsnp, an r package for fast multivariate analyses of big genomic data
Salvador Herrando-Pérez, Raymond Tobler, Christian D. Huber, 2021, Methods in Ecology and Evolution on p. 2084-2093
The biasing impact of irrelevant contextual information on forensic odontology radiograph matching decisions
Sher Lin Chiam, Itiel E. Dror, Christian D. Huber, Denice Higgins, 2021, Forensic Science International
An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia
Yassine Souilmi, M. Elise Lauterbur, Ray Tobler, Christian D. Huber, Angad S. Johar, Shayli Varasteh Moradi, Wayne A. Johnston, Nevan J. Krogan, Kirill Alexandrov, David Enard, 2021, Current Biology on p. 3504-3514.e9
Erratum: “An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia” (Current Biology (2021) 31(16) (3504–3514.e9), (S0960982221007946), (10.1016/j.cub.2021.05.067))
Yassine Souilmi, M. Elise Lauterbur, Ray Tobler, Christian D. Huber, Angad S. Johar, Shayli Varasteh Moradi, Wayne A. Johnston, Nevan J. Krogan, Kirill Alexandrov, David Enard, 2021, Current Biology on p. 3704
Authors’ Reply to Letter to the Editor: Neutral genetic diversity as a useful tool for conservation biology
João C. Teixeira, Christian D. Huber, 2021, Conservation Genetics on p. 547-549
Most-Cited Papers
Massive genomic variation and strong selection in Arabidopsis thaliana lines from Sweden
Quan Long, Fernando A. Rabanal, Dazhe Meng, Christian D. Huber, Ashley Farlow, Alexander Platzer, Qingrun Zhang, Bjarni J. Vilhjálmsson, Arthur Korte, Viktoria Nizhynska, Viktor Voronin, Pamela Korte, Laura Sedman, Terezie Mandáková, Martin A. Lysak, Ümit Seren, Ines Hellmann, Magnus Nordborg, 2013, Nature Genetics on p. 884-890
The inflated significance of neutral genetic diversity in conservation genetics
João C. Teixeira, Christian D. Huber, 2021, Proceedings of the National Academy of Sciences of the United States of America
SweepFinder2: Increased sensitivity, robustness and flexibility
M DeGiorgio, Christian Huber, Melissa Hubisz, Ines Hellmann, Rasmus Nielsen, 2016, Bioinformatics on p. 1895--1897
Inference of the distribution of selection coefficients for new nonsynonymous mutations using large samples
Bernard Y. Kim, Christian D. Huber, Kirk E. Lohmueller, 2017, Genetics on p. 345-361
Detecting recent selective sweeps while controlling for mutation rate and background selection
Christian Huber, M DeGiorgio, Ines Hellmann, Rasmus Nielsen, 2016, Molecular Ecology on p. 142--156
Determining the factors driving selective effects of new nonsynonymous mutations
Christian D. Huber, Bernard Y. Kim, Clare D. Marsden, Kirk E. Lohmueller, 2017, Proceedings of the National Academy of Sciences of the United States of America on p. 4465-4470
Variation in thermal performance and reaction norms among populations of drosophila melanogaster
Peter Klepsatel, Martina Gáliková, Nicola De Maio, Christian D. Huber, Christian Schlötterer, Thomas Flatt, 2013, Evolution; international journal of organic evolution on p. 3573-3587
Gene expression drives the evolution of dominance
Christian D. Huber, Arun Durvasula, Angela M. Hancock, Kirk E. Lohmueller, 2018, Nature Communications
Deleterious variation shapes the genomic landscape of introgression
Bernard Y. Kim, Christian D. Huber, Kirk E. Lohmueller, 2018, PLoS Genetics
Similarities and differences in altitudinal versus latitudinal variation for morphological traits in drosophila melanogaster
Peter Klepsatel, Martina Gáliková, Christian D. Huber, Thomas Flatt, 2014, Evolution; international journal of organic evolution on p. 1385-1398