Bernhard Luscher

Emphasis Area Representative, Neurobiology; Director of the Center for Molecular Investigation of Neurological Disorders; Professor of Biology, Biochemistry and Molecular Biology

Bernhard Luscher

Research Summary

Function of GABAergic synaptic transmission in health and disease, with emphasis of stress based psychiatric disorders such as major depressive disorders and mechanisms of antidepressant drug action

Graduate Students

Huck Affiliations

Links

Publication Tags

Gamma Aminobutyric Acid Brain Gaba A Receptors Neurons Proteins Lipoylation Genes Human Herpesvirus 1 Antidepressive Agents Anxiety Synaptic Transmission Aminobutyrates Depression Palmitoylation Major Depressive Disorder Phenotype Membranes Gephyrin Glycoproteins Diazepam Interneurons Anti Anxiety Agents Ketamine Facilitative Glucose Transport Proteins Dopamine D2 Receptors

Most Recent Papers

Reversal of a Treatment-Resistant, Depression-Related Brain State with the Kv7 Channel Opener Retigabine

Mengyang Feng, Nicole A. Crowley, Akshilkumar Patel, Yao Guo, Sierra E. Bugni, Bernhard Luscher, 2019, Neuroscience on p. 109-125

Gluconate suppresses seizure activity in developing brains by inhibiting CLC-3 chloride channels

Zheng Wu, Qingwei Huo, Liang Ren, Fengping Dong, Mengyang Feng, Yue Wang, Yuting Bai, Bernhard Luscher, Sheng Tian Li, Guan Lei Wang, Cheng Long, Yun Wang, Gangyi Wu, Gong Chen, 2019, Molecular Brain

Ketamine normalizes binge drinking-induced defects in glutamatergic synaptic transmission and ethanol drinking behavior in female but not male mice

Nicole Crowley, Sarah N. Magee, Mengyang Feng, Sarah J. Jefferson, Christian J. Morris, Nigel C. Dao, Dakota F. Brockway, Bernhard Luscher, 2019, Neuropharmacology on p. 35-44

Adolescent Social Stress Increases Anxiety-like Behavior and Alters Synaptic Transmission, Without Influencing Nicotine Responses, in a Sex-Dependent Manner

Michael J. Caruso, Nicole Crowley, Dana E. Reiss, Jasmine I. Caulfield, Bernhard Luscher, Sonia Angele Cavigelli, Helen Marie Kamens, 2018, Neuroscience on p. 182-198

The absence of DHHC3 affects primary and latent herpes simplex virus 1 infection

Shaohui Wang, Kevin R. Mott, Marianne Cilluffo, Casey L. Kilpatrick, Shoko Murakami, Alexander V. Ljubimov, Konstantin G. Kousoulas, Sita Awasthi, Bernhard Luscher, Homayon Ghiasi, 2018, Journal of virology

Binding of herpes simplex virus 1 UL20 to GODZ (DHHC3) affects its palmitoylation and is essential for infectivity and proper targeting and localization of UL20 and glycoprotein K

Shaohui Wang, Kevin R. Mott, Kolja Wawrowsky, Konstantin G. Kousoulas, Bernhard Luscher, Homayon Ghiasi, 2017, Journal of virology

Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state

T. Fuchs, S. J. Jefferson, A. Hooper, P. H. Yee, J. Maguire, B. Luscher, 2017, Molecular Psychiatry on p. 920-930

DHHC7 palmitoylates glucose transporter 4 (Glut4) and regulates Glut4 membrane translocation

Keyong Du, Shoko Murakami, Yingmin Sun, Casey L. Kilpatrick, Bernhard Luscher, 2017, Journal of Biological Chemistry on p. 2979-2991

Dissociation of Golgi-associated DHHC-type zinc finger protein (GODZ)- and Sertoli cell gene with a zinc finger domain-β (SERZ-β)-mediated palmitoylation by loss of function analyses in knock-out mice

Casey L. Kilpatrick, Shoko Murakami, Mengyang Feng, Xia Wu, Rachnanjali Lal, Gong Chen, Keyong Du, Bernhard Luscher, 2016, Journal of Biological Chemistry on p. 27371-27386

Increased motor-impairing effects of the neuroactive steroid pregnanolone in mice with targeted inactivation of the GABA<sub>A</sub> receptor γ2 subunit in the cerebellum

Elli Leppä, Anni Maija Linden, Maria I. Aller, Peer Wulff, Olga Vekovischeva, Bernhard Luscher, Hartmut Lüddens, William Wisden, Esa R. Korpi, 2016, Frontiers in Pharmacology

Most-Cited Papers

γ-aminobutyric acid-type A receptor deficits cause hypothalamic-pituitary-adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depression

Qiuying Shen, Rachnanjali Lal, Beth A. Luellen, John C. Earnheart, Anne Milasincic Andrews, Bernhard Luscher, 2010, Biological Psychiatry on p. 512-520

Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state

T. Fuchs, S. J. Jefferson, A. Hooper, P. H. Yee, J. Maguire, B. Luscher, 2017, Molecular Psychiatry on p. 920-930

Palmitoylation of Gephyrin Controls Receptor Clustering and Plasticity of GABAergic Synapses

Borislav Dejanovic, Marcus Semtner, Silvia Ebert, Tobias Lamkemeyer, Franziska Neuser, Bernhard Lüscher, Jochen C. Meier, Guenter Schwarz, 2014, PLoS biology on p. 1-16

Knockdown of GABA<sub>A</sub> receptor signaling in gnrh neurons has minimal effects upon fertility

Kiho Lee, Robert Porteous, Rebecca E. Campbell, Bernhard Luscher, Allan E. Herbison, 2010, Endocrinology on p. 4428-4436

γ-aminobutyric acid type A (GABA <sub>A</sub>) receptor α subunits play a direct role in synaptic Versus extrasynaptic targeting

Xia Wu, Zheng Wu, Gang Ning, Yao Guo, Rashid Ali, Robert L. Macdonald, Angel L. De Blas, Bernhard Luscher, Gong Chen, 2012, Journal of Biological Chemistry on p. 27417-27430

Multiple molecular mechanisms for a single GABA<sub>A</sub> mutation in epilepsy

Christopher A. Reid, Taehwan Kim, A. Marie Phillips, Jun Low, Samuel F. Berkovic, Bernhard Luscher, Steven Petrou, 2013, Neurology on p. 1003-1008

GABAergic Control of Critical Developmental Periods for Anxiety- and Depression-Related Behavior in Mice

Qiuying Shen, Thomas Fuchs, Nadia Sahir, Bernhard Luscher, 2012, PloS one

Defects in dendrite and spine maturation and synaptogenesis associated with an anxious-depressive-like phenotype of GABA<sub>A</sub> receptor-deficient mice

Zhen Ren, Nadia Sahir, Shoko Murakami, Beth A. Luellen, John C. Earnheart, Rachnanjali Lal, Ju Young Kim, Hongjun Song, Bernhard Luscher, 2015, Neuropharmacology on p. 171-179

GABAergic control of depression-related brain states

Bernhard Luscher, Thomas Fuchs, 2015, Advances in Pharmacology on p. 97-144

Effect of C-Terminal S-palmitoylation on D2 dopamine receptor trafficking and stability

Brittany Ebersole, Jessica Petko, Matthew Woll, Shoko Murakami, Kate Sokolina, Victoria Wong, Igor Stagljar, Bernhard Lüscher, Robert Levenson, 2015, PloS one