Bernhard Luscher

Emphasis Area Representative, Neurobiology; Director of the Center for Molecular Investigation of Neurological Disorders; Professor of Biology, Biochemistry and Molecular Biology

Bernhard Luscher

Research Summary

Function of GABAergic synaptic transmission in health and disease, with emphasis of stress based psychiatric disorders such as major depressive disorders and mechanisms of antidepressant drug action

Huck Affiliations

Links

Publication Tags

Gamma Aminobutyric Acid Brain Antidepressive Agents Ketamine Depression Synaptic Transmission Gaba A Receptors Human Herpesvirus 1 Proteins Major Depressive Disorder Synapses Anxiety Gephyrin Interneurons Glycoproteins Neurotransmitter Agents Aminobutyrates Genes Lipoylation Palmitoylation Diazepam Neurons Phenotype Pregnanolone Brexanolone

Most Recent Papers

Antidepressant mechanisms of ketamine

Bernhard Luscher, Mengyang Feng, Sarah J. Jefferson, 2020, on p. 43-78

Disinhibition of somatostatin interneurons confers resilience to stress in male but not female mice

Sarah Jefferson, Mengyang Feng, Uree Chon, Yongsoo Kim, Bernhard Luscher, 2020, Neurobiology of Stress

Reversal of a treatment-resistant, depression-related brain state with the Kv7 channel opener retigabine

Mengyang Feng, Nicole A. Crowley, Akshilkumar Patel, Yao Guo, Sierra E. Bugni, Bernhard Luscher, 2019, Neuroscience on p. 109-125

Gluconate suppresses seizure activity in developing brains by inhibiting CLC-3 chloride channels

Zheng Wu, Qingwei Huo, Liang Ren, Fengping Dong, Mengyang Feng, Yue Wang, Yuting Bai, Bernhard Luscher, Sheng Tian Li, Guan Lei Wang, Cheng Long, Yun Wang, Gangyi Wu, Gong Chen, 2019, Molecular Brain

Ketamine normalizes binge drinking-induced defects in glutamatergic synaptic transmission and ethanol drinking behavior in female but not male mice

Nicole Crowley, Sarah N. Magee, Mengyang Feng, Sarah J. Jefferson, Christian J. Morris, Nigel C. Dao, Dakota F. Brockway, Bernhard Luscher, 2019, Neuropharmacology on p. 35-44

Brexanolone, a neurosteroid antidepressant, vindicates the gabaergic deficit hypothesis of depression and may foster resilience [version 1; peer review

Bernhard Lüscher, Hanns Möhler, 2019, F1000Research

GABAA receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Delia Belelli, Tim Hales, Jeremy Lambert, Bernhard Luscher, Richard Olsen, John Peters, Uwe Rudolph, Werner Sieghart, 2019, IUPHAR/BPS Guide to Pharmacology CITE

Adolescent social stress increases anxiety-like behavior and alters synaptic transmission, without influencing nicotine responses, in a sex-dependent manner

Michael J. Caruso, Nicole Crowley, Dana E. Reiss, Jasmine I. Caulfield, Bernhard Luscher, Sonia Angele Cavigelli, Helen Marie Kamens, 2018, Neuroscience on p. 182-198

The absence of DHHC3 affects primary and latent herpes simplex virus 1 infection

Shaohui Wang, Kevin R. Mott, Marianne Cilluffo, Casey L. Kilpatrick, Shoko Murakami, Alexander V. Ljubimov, Konstantin G. Kousoulas, Sita Awasthi, Bernhard Luscher, Homayon Ghiasi, 2018, Journal of Virology

Binding of herpes simplex virus 1 UL20 to GODZ (DHHC3) affects its palmitoylation and is essential for infectivity and proper targeting and localization of UL20 and glycoprotein K

Shaohui Wang, Kevin R. Mott, Kolja Wawrowsky, Konstantin G. Kousoulas, Bernhard Luscher, Homayon Ghiasi, 2017, Journal of Virology on p. e00945–17

Most-Cited Papers

The GABAergic deficit hypothesis of major depressive disorder

B. Luscher, Q. Shen, N. Sahir, 2011, Molecular Psychiatry on p. 383-406

Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision

Juan Song, Chun Zhong, Michael A. Bonaguidi, Gerald J. Sun, Derek Hsu, Yan Gu, Konstantinos Meletis, Z. Josh Huang, Shaoyu Ge, Grigori Enikolopov, Karl Deisseroth, Bernhard Luscher, Kimberly M. Christian, Guo Li Ming, Hongjun Song, 2012, Nature on p. 150-154

GABA<sub>A</sub> Receptor Trafficking-Mediated Plasticity of Inhibitory Synapses

Bernhard Luscher, Thomas Fuchs, Casey L. Kilpatrick, 2011, Neuron on p. 385-409

Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state

T. Fuchs, S. J. Jefferson, A. Hooper, P. H. Yee, J. Maguire, B. Luscher, 2017, Molecular Psychiatry on p. 920-930

GABAergic control of depression-related brain states

Bernhard Luscher, Thomas Fuchs, 2015, Advances in Pharmacology on p. 97-144

Multiple molecular mechanisms for a single GABA<sub>A</sub> mutation in epilepsy

Christopher A. Reid, Taehwan Kim, A. Marie Phillips, Jun Low, Samuel F. Berkovic, Bernhard Luscher, Steven Petrou, 2013, Neurology on p. 1003-1008

Palmitoylation of Gephyrin Controls Receptor Clustering and Plasticity of GABAergic Synapses

Borislav Dejanovic, Marcus Semtner, Silvia Ebert, Tobias Lamkemeyer, Franziska Neuser, Bernhard Lüscher, Jochen C. Meier, Guenter Schwarz, 2014, PLoS Biology on p. 1-16

Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment

Zhen Ren, Horia Pribiag, Sarah J. Jefferson, Matthew Shorey, Thomas Fuchs, David Stellwagen, Bernhard Luscher, 2016, Biological Psychiatry on p. 457-468

γ-aminobutyric acid type A (GABA <sub>A</sub>) receptor α subunits play a direct role in synaptic Versus extrasynaptic targeting

Xia Wu, Zheng Wu, Gang Ning, Yao Guo, Rashid Ali, Robert L. Macdonald, Angel L. De Blas, Bernhard Luscher, Gong Chen, 2012, Journal of Biological Chemistry on p. 27417-27430

GABAergic Control of Critical Developmental Periods for Anxiety- and Depression-Related Behavior in Mice

Qiuying Shen, Thomas Fuchs, Nadia Sahir, Bernhard Luscher, 2012, PLoS One