Bernhard Luscher

Emphasis Area Representative, Neurobiology; Director of the Center for Molecular Investigation of Neurological Disorders; Professor of Biology, Biochemistry and Molecular Biology;

Bernhard Luscher

Research Summary

Function of GABAergic synaptic transmission in health and disease, with emphasis of stress based psychiatric disorders such as major depressive disorders and mechanisms of antidepressant drug action

Huck Institutes Affiliations

Links

Publication Tags

Gamma Aminobutyric Acid Proteins Neurons Genes Lipoylation Anxiety Membranes Brain Depression Human Herpesvirus 1 Gephyrin Palmitoylation Antidepressive Agents Phenotype Synaptic Transmission Glycoproteins Synapses Major Depressive Disorder Diazepam Interneurons Gaba A Receptors Dopamine D2 Receptors Facilitative Glucose Transport Proteins Epilepsy Mice

Most Recent Papers

Adolescent Social Stress Increases Anxiety-like Behavior and Alters Synaptic Transmission, Without Influencing Nicotine Responses, in a Sex-Dependent Manner

Michael J. Caruso, Nicole A. Crowley, Dana E. Reiss, Jasmine I. Caulfield, Bernhard Luscher, Sonia A. Cavigelli, Helen M. Kamens, 2018, Neuroscience on p. 182-198

The absence of DHHC3 affects primary and latent herpes simplex virus 1 infection

Shaohui Wang, Kevin R. Mott, Marianne Cilluffo, Casey L. Kilpatrick, Shoko Murakami, Alexander V. Ljubimov, Konstantin G. Kousoulas, Sita Awasthi, Bernhard Luscher, Homayon Ghiasi, 2018, Journal of virology

Binding of herpes simplex virus 1 UL20 to GODZ (DHHC3) affects its palmitoylation and is essential for infectivity and proper targeting and localization of UL20 and glycoprotein K

Shaohui Wang, Kevin R. Mott, Kolja Wawrowsky, Konstantin G. Kousoulas, Bernhard Luscher, Homayon Ghiasi, 2017, Journal of virology

Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state

T. Fuchs, S. J. Jefferson, A. Hooper, P. H. Yee, J. Maguire, B. Luscher, 2017, Molecular Psychiatry on p. 920-930

DHHC7 palmitoylates glucose transporter 4 (Glut4) and regulates Glut4 membrane translocation

Keyong Du, Shoko Murakami, Yingmin Sun, Casey L. Kilpatrick, Bernhard Luscher, 2017, Journal of Biological Chemistry on p. 2979-2991

Dissociation of Golgi-associated DHHC-type zinc finger protein (GODZ)- and Sertoli cell gene with a zinc finger domain-β (SERZ-β)-mediated palmitoylation by loss of function analyses in knock-out mice

Casey L. Kilpatrick, Shoko Murakami, Mengyang Feng, Xia Wu, Rachnanjali Lal, Gong Chen, Keyong Du, Bernhard Luscher, 2016, Journal of Biological Chemistry on p. 27371-27386

Increased motor-impairing effects of the neuroactive steroid pregnanolone in mice with targeted inactivation of the GABA<sub>A</sub> receptor γ2 subunit in the cerebellum

Elli Leppä, Anni Maija Linden, Maria I. Aller, Peer Wulff, Olga Vekovischeva, Bernhard Luscher, Hartmut Lüddens, William Wisden, Esa R. Korpi, 2016, Frontiers in Pharmacology

Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment

Zhen Ren, Horia Pribiag, Sarah J. Jefferson, Matthew Shorey, Thomas Fuchs, David Stellwagen, Bernhard Luscher, 2016, Biological Psychiatry on p. 457-468

Effect of C-Terminal S-palmitoylation on D2 dopamine receptor trafficking and stability

Brittany Ebersole, Jessica Petko, Matthew Woll, Shoko Murakami, Kate Sokolina, Victoria Wong, Igor Stagljar, Bernhard Lüscher, Robert Levenson, 2015, PloS one

Defects in dendrite and spine maturation and synaptogenesis associated with an anxious-depressive-like phenotype of GABA<sub>A</sub> receptor-deficient mice

Zhen Ren, Nadia Sahir, Shoko Murakami, Beth A. Luellen, John C. Earnheart, Rachnanjali Lal, Ju Young Kim, Hongjun Song, Bernhard Luscher, 2015, Neuropharmacology on p. 171-179

High-Impact Papers

Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision

Juan Song, Chun Zhong, Michael A. Bonaguidi, Gerald J. Sun, Derek Hsu, Yan Gu, Konstantinos Meletis, Z. Josh Huang, Shaoyu Ge, Grigori Enikolopov, Karl Deisseroth, Bernhard Luscher, Kimberly M. Christian, Guo Li Ming, Hongjun Song, 2012, Nature on p. 150-154

A balanced chromosomal translocation disrupting ARHGEF9 is associated with epilepsy, anxiety, aggression, and mental retardation

Vera M. Kalscheuer, Luciana Musante, Cheng Fang, Kirsten Hoffmann, Celine Fuchs, Eloisa Carta, Emma Deas, Kanamarlapudi Venkateswarlu, Corinna Menzel, Reinhard Ullmann, Niels Tommerup, Leda Dalprà, Andreas Tzschach, Angelo Selicorni, Bernhard Lüscher, Hans Hilger Ropers, Kirsten Harvey, Robert J. Harvey, 2009, Human Mutation on p. 61-68

γ-aminobutyric acid-type A receptor deficits cause hypothalamic-pituitary-adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depression

Qiuying Shen, Rachnanjali Lal, Beth A. Luellen, John C. Earnheart, Anne Milasincic Andrews, Bernhard Luscher, 2010, Biological Psychiatry on p. 512-520

Knockdown of GABA<sub>A</sub> receptor signaling in gnrh neurons has minimal effects upon fertility

Kiho Lee, Robert Porteous, Rebecca E. Campbell, Bernhard Lüscher, Allan E. Herbison, 2010, Endocrinology on p. 4428-4436

γ-aminobutyric acid type A (GABA <sub>A</sub>) receptor α subunits play a direct role in synaptic Versus extrasynaptic targeting

Xia Wu, Zheng Wu, Gang Ning, Yao Guo, Rashid Ali, Robert L. Macdonald, Angel L. De Blas, Bernhard Luscher, Gong Chen, 2012, Journal of Biological Chemistry on p. 27417-27430

Multiple molecular mechanisms for a single GABA<sub>A</sub> mutation in epilepsy

Christopher A. Reid, Taehwan Kim, A. Marie Phillips, Jun Low, Samuel F. Berkovic, Bernhard Luscher, Steven Petrou, 2013, Neurology on p. 1003-1008

Palmitoylation of Gephyrin Controls Receptor Clustering and Plasticity of GABAergic Synapses

Borislav Dejanovic, Marcus Semtner, Silvia Ebert, Tobias Lamkemeyer, Franziska Neuser, Bernhard Lüscher, Jochen C. Meier, Guenter Schwarz, 2014, PLoS Biology on p. 1-16

Calcium-modulating cyclophilin ligand regulates membrane trafficking of postsynaptic GABA<sub>A</sub> receptors

Xu Yuan, Jun Yao, David Norris, David D. Tran, Richard J. Bram, Gong Chen, Bernhard Luscher, 2008, Molecular and Cellular Neuroscience on p. 277-289

GABAergic Control of Critical Developmental Periods for Anxiety- and Depression-Related Behavior in Mice

Qiuying Shen, Thomas Fuchs, Nadia Sahir, Bernhard Luscher, 2012, PloS one

GABAergic control of depression-related brain states

Bernhard Luscher, Thomas Fuchs, 2015, Advances in Pharmacology on p. 97-144