Bernhard Luscher

Emphasis Area Representative, Neurobiology; Director of the Center for Molecular Investigation of Neurological Disorders; Professor of Biology, Biochemistry and Molecular Biology

Bernhard Luscher

Research Summary

Function of GABAergic synaptic transmission in health and disease, with emphasis of stress based psychiatric disorders such as major depressive disorders and mechanisms of antidepressant drug action

Huck Institutes Affiliations

Links

Publication Tags

Gamma Aminobutyric Acid Brain Gaba A Receptors Neurons Proteins Genes Anxiety Depression Ketamine Human Herpesvirus 1 Antidepressive Agents Synaptic Transmission Lipoylation Gephyrin Membranes Aminobutyrates Interneurons Synapses Glycoproteins Somatostatin Palmitoylation Diazepam Major Depressive Disorder Anti Anxiety Agents Facilitative Glucose Transport Proteins

Most Recent Papers

Reversal of a Treatment-Resistant, Depression-Related Brain State with the Kv7 Channel Opener Retigabine

Mengyang Feng, Nicole Crowley, Akshilkumar Patel, Yao Guo, Sierra E. Bugni, Bernhard Luscher, 2019, Neuroscience on p. 109-125

Ketamine normalizes binge drinking-induced defects in glutamatergic synaptic transmission and ethanol drinking behavior in female but not male mice

Nicole Crowley, Sarah N. Magee, Mengyang Feng, Sarah J. Jefferson, Christian J. Morris, Nigel C. Dao, Dakota F. Brockway, Bernhard Luscher, 2019, Neuropharmacology on p. 35-44

Adolescent Social Stress Increases Anxiety-like Behavior and Alters Synaptic Transmission, Without Influencing Nicotine Responses, in a Sex-Dependent Manner

Michael J. Caruso, Nicole Crowley, Dana E. Reiss, Jasmine I. Caulfield, Bernhard Luscher, Sonia Angele Cavigelli, Helen Marie Kamens, 2018, Neuroscience on p. 182-198

The absence of DHHC3 affects primary and latent herpes simplex virus 1 infection

Shaohui Wang, Kevin R. Mott, Marianne Cilluffo, Casey L. Kilpatrick, Shoko Murakami, Alexander V. Ljubimov, Konstantin G. Kousoulas, Sita Awasthi, Bernhard Luscher, Homayon Ghiasi, 2018, Journal of virology

Binding of herpes simplex virus 1 UL20 to GODZ (DHHC3) affects its palmitoylation and is essential for infectivity and proper targeting and localization of UL20 and glycoprotein K

Shaohui Wang, Kevin R. Mott, Kolja Wawrowsky, Konstantin G. Kousoulas, Bernhard Luscher, Homayon Ghiasi, 2017, Journal of virology

Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state

T. Fuchs, S. J. Jefferson, A. Hooper, P. H. Yee, J. Maguire, Bernhard Luscher, 2017, Molecular Psychiatry on p. 920-930

DHHC7 palmitoylates glucose transporter 4 (Glut4) and regulates Glut4 membrane translocation

Keyong Du, Shoko Murakami, Yingmin Sun, Casey L. Kilpatrick, Bernhard Luscher, 2017, Journal of Biological Chemistry on p. 2979-2991

Dissociation of Golgi-associated DHHC-type zinc finger protein (GODZ)- and Sertoli cell gene with a zinc finger domain-β (SERZ-β)-mediated palmitoylation by loss of function analyses in knock-out mice

Casey L. Kilpatrick, Shoko Murakami, Mengyang Feng, Xia Wu, Rachnanjali Lal, Gong Chen, Keyong Du, Bernhard Luscher, 2016, Journal of Biological Chemistry on p. 27371-27386

Increased motor-impairing effects of the neuroactive steroid pregnanolone in mice with targeted inactivation of the GABA<sub>A</sub> receptor γ2 subunit in the cerebellum

Elli Leppä, Anni Maija Linden, Maria I. Aller, Peer Wulff, Olga Vekovischeva, Bernhard Luscher, Hartmut Lüddens, William Wisden, Esa R. Korpi, 2016, Frontiers in Pharmacology

Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment

Zhen Ren, Horia Pribiag, Sarah J. Jefferson, Matthew Shorey, Thomas Fuchs, David Stellwagen, Bernhard Luscher, 2016, Biological Psychiatry on p. 457-468

High-Impact Papers

Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision

Juan Song, Chun Zhong, Michael A. Bonaguidi, Gerald J. Sun, Derek Hsu, Yan Gu, Konstantinos Meletis, Z. Josh Huang, Shaoyu Ge, Grigori Enikolopov, Karl Deisseroth, Bernhard Luscher, Kimberly M. Christian, Guo Li Ming, Hongjun Song, 2012, Nature on p. 150-154

A balanced chromosomal translocation disrupting ARHGEF9 is associated with epilepsy, anxiety, aggression, and mental retardation

Vera M. Kalscheuer, Luciana Musante, Cheng Fang, Kirsten Hoffmann, Celine Fuchs, Eloisa Carta, Emma Deas, Kanamarlapudi Venkateswarlu, Corinna Menzel, Reinhard Ullmann, Niels Tommerup, Leda Dalprà, Andreas Tzschach, Angelo Selicorni, Bernhard Luscher, Hans Hilger Ropers, Kirsten Harvey, Robert J. Harvey, 2009, Human mutation on p. 61-68

γ-aminobutyric acid-type A receptor deficits cause hypothalamic-pituitary-adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depression

Qiuying Shen, Rachnanjali Lal, Beth A. Luellen, John C. Earnheart, Anne Milasincic Andrews, Bernhard Luscher, 2010, Biological Psychiatry on p. 512-520

Palmitoylation of Gephyrin Controls Receptor Clustering and Plasticity of GABAergic Synapses

Borislav Dejanovic, Marcus Semtner, Silvia Ebert, Tobias Lamkemeyer, Franziska Neuser, Bernhard Luscher, Jochen C. Meier, Guenter Schwarz, 2014, PLoS Biology on p. 1-16

γ-aminobutyric acid type A (GABA <sub>A</sub>) receptor α subunits play a direct role in synaptic Versus extrasynaptic targeting

Xia Wu, Zheng Wu, Gang Ning, Yao Guo, Rashid Ali, Robert L. Macdonald, Angel L. De Blas, Bernhard Luscher, Gong Chen, 2012, Journal of Biological Chemistry on p. 27417-27430

Knockdown of GABA<sub>A</sub> receptor signaling in gnrh neurons has minimal effects upon fertility

Kiho Lee, Robert Porteous, Rebecca E. Campbell, Bernhard Luscher, Allan E. Herbison, 2010, Endocrinology on p. 4428-4436

Multiple molecular mechanisms for a single GABA<sub>A</sub> mutation in epilepsy

Christopher A. Reid, Taehwan Kim, A. Marie Phillips, Jun Low, Samuel F. Berkovic, Bernhard Luscher, Steven Petrou, 2013, Neurology on p. 1003-1008

Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state

T. Fuchs, S. J. Jefferson, A. Hooper, P. H. Yee, J. Maguire, Bernhard Luscher, 2017, Molecular Psychiatry on p. 920-930

GABAergic Control of Critical Developmental Periods for Anxiety- and Depression-Related Behavior in Mice

Qiuying Shen, Thomas Fuchs, Nadia Sahir, Bernhard Luscher, 2012, PLoS One

Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment

Zhen Ren, Horia Pribiag, Sarah J. Jefferson, Matthew Shorey, Thomas Fuchs, David Stellwagen, Bernhard Luscher, 2016, Biological Psychiatry on p. 457-468