Bernhard Luscher

Emphasis Area Representative, Neurobiology; Director of the Center for Molecular Investigation of Neurological Disorders; Professor of Biology, Biochemistry and Molecular Biology

Bernhard Luscher

Research Summary

Function of GABAergic synaptic transmission in health and disease, with emphasis of stress based psychiatric disorders such as major depressive disorders and mechanisms of antidepressant drug action

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Gamma Aminobutyric Acid Brain Human Herpesvirus 1 Lipoylation Synaptic Transmission Palmitoylation Anxiety Proteins Gaba A Receptors Ketamine Interneurons Phenotype Antidepressive Agents Membranes Gephyrin Glycoproteins Genes Neurons Major Depressive Disorder Somatostatin Depression Diazepam Dopamine D2 Receptors Aminobutyrates Anti Anxiety Agents

Most Recent Papers

Disinhibition of somatostatin interneurons confers resilience to stress in male but not female mice

Sarah Jefferson, Mengyang Feng, Uree Chon, Yongsoo Kim, Bernhard Luscher, 2020, Neurobiology of Stress

Gluconate suppresses seizure activity in developing brains by inhibiting CLC-3 chloride channels

Zheng Wu, Qingwei Huo, Liang Ren, Fengping Dong, Mengyang Feng, Yue Wang, Yuting Bai, Bernhard Luscher, Sheng Tian Li, Guan Lei Wang, Cheng Long, Yun Wang, Gangyi Wu, Gong Chen, 2019, Molecular Brain

Reversal of a treatment-resistant, depression-related brain state with the Kv7 channel opener retigabine

Mengyang Feng, Nicole A. Crowley, Akshilkumar Patel, Yao Guo, Sierra E. Bugni, Bernhard Luscher, 2019, Neuroscience on p. 109-125

Ketamine normalizes binge drinking-induced defects in glutamatergic synaptic transmission and ethanol drinking behavior in female but not male mice

Nicole Crowley, Sarah N. Magee, Mengyang Feng, Sarah J. Jefferson, Christian J. Morris, Nigel C. Dao, Dakota F. Brockway, Bernhard Luscher, 2019, Neuropharmacology on p. 35-44

Brexanolone, a neurosteroid antidepressant, vindicates the GABAergic deficit hypothesis of depression and may foster resilience

Bernhard Luscher, H. Mohler, 2019, F1000Res on p. pp751

GABAA receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Delia Belelli, Tim Hales, Jeremy Lambert, Bernhard Luscher, Richard Olsen, John Peters, Uwe Rudolph, Werner Sieghart, 2019, IUPHAR/BPS Guide to Pharmacology CITE

Adolescent social stress increases anxiety-like behavior and alters synaptic transmission, without influencing nicotine responses, in a sex-dependent manner

Michael J. Caruso, Nicole Crowley, Dana E. Reiss, Jasmine I. Caulfield, Bernhard Luscher, Sonia Angele Cavigelli, Helen Marie Kamens, 2018, Neuroscience on p. 182-198

The absence of DHHC3 affects primary and latent herpes simplex virus 1 infection

Shaohui Wang, Kevin R. Mott, Marianne Cilluffo, Casey L. Kilpatrick, Shoko Murakami, Alexander V. Ljubimov, Konstantin G. Kousoulas, Sita Awasthi, Bernhard Luscher, Homayon Ghiasi, 2018, Journal of virology

Binding of herpes simplex virus 1 UL20 to GODZ (DHHC3) affects its palmitoylation and is essential for infectivity and proper targeting and localization of UL20 and glycoprotein K

Shaohui Wang, Kevin R. Mott, Kolja Wawrowsky, Konstantin G. Kousoulas, Bernhard Luscher, Homayon Ghiasi, 2017, Journal of virology on p. e00945–17

Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state

T. Fuchs, S. J. Jefferson, A. Hooper, P. H. Yee, J. Maguire, B. Luscher, 2017, Molecular Psychiatry on p. 920-930

Most-Cited Papers

Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision

Juan Song, Chun Zhong, Michael A. Bonaguidi, Gerald J. Sun, Derek Hsu, Yan Gu, Konstantinos Meletis, Z. Josh Huang, Shaoyu Ge, Grigori Enikolopov, Karl Deisseroth, Bernhard Luscher, Kimberly M. Christian, Guo Li Ming, Hongjun Song, 2012, Nature on p. 150-154

Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state

T. Fuchs, S. J. Jefferson, A. Hooper, P. H. Yee, J. Maguire, B. Luscher, 2017, Molecular Psychiatry on p. 920-930

Palmitoylation of Gephyrin Controls Receptor Clustering and Plasticity of GABAergic Synapses

Borislav Dejanovic, Marcus Semtner, Silvia Ebert, Tobias Lamkemeyer, Franziska Neuser, Bernhard Lüscher, Jochen C. Meier, Guenter Schwarz, 2014, PLoS biology on p. 1-16

Multiple molecular mechanisms for a single GABA<sub>A</sub> mutation in epilepsy

Christopher A. Reid, Taehwan Kim, A. Marie Phillips, Jun Low, Samuel F. Berkovic, Bernhard Luscher, Steven Petrou, 2013, Neurology on p. 1003-1008

Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment

Zhen Ren, Horia Pribiag, Sarah J. Jefferson, Matthew Shorey, Thomas Fuchs, David Stellwagen, Bernhard Luscher, 2016, Biological Psychiatry on p. 457-468

γ-aminobutyric acid type A (GABA <sub>A</sub>) receptor α subunits play a direct role in synaptic Versus extrasynaptic targeting

Xia Wu, Zheng Wu, Gang Ning, Yao Guo, Rashid Ali, Robert L. Macdonald, Angel L. De Blas, Bernhard Luscher, Gong Chen, 2012, Journal of Biological Chemistry on p. 27417-27430

GABAergic Control of Critical Developmental Periods for Anxiety- and Depression-Related Behavior in Mice

Qiuying Shen, Thomas Fuchs, Nadia Sahir, Bernhard Luscher, 2012, PloS one

Defects in dendrite and spine maturation and synaptogenesis associated with an anxious-depressive-like phenotype of GABA<sub>A</sub> receptor-deficient mice

Zhen Ren, Nadia Sahir, Shoko Murakami, Beth A. Luellen, John C. Earnheart, Rachnanjali Lal, Ju Young Kim, Hongjun Song, Bernhard Luscher, 2015, Neuropharmacology on p. 171-179

Effect of C-Terminal S-palmitoylation on D2 dopamine receptor trafficking and stability

Brittany Ebersole, Jessica Petko, Matthew Woll, Shoko Murakami, Kate Sokolina, Victoria Wong, Igor Stagljar, Bernhard Lüscher, Robert Levenson, 2015, PloS one

DHHC7 palmitoylates glucose transporter 4 (Glut4) and regulates Glut4 membrane translocation

Keyong Du, Shoko Murakami, Yingmin Sun, Casey L. Kilpatrick, Bernhard Luscher, 2017, Journal of Biological Chemistry on p. 2979-2991