Aron Lukacher
Professor and Chair of Microbiology & Immunology
Huck Affiliations
Publication Tags
T Lymphocytes Polyomavirus Brain Infection Viruses Infections Interleukin 21 Antibodies Progressive Multifocal Leukoencephalopathy Mutation Virus Diseases Homeostasis Jc Virus Polyomavirus Infections Mus Musculus Polyomavirus 1 B Lymphocytes Maintenance Autoimmunity Cell Differentiation Germinal Center Antigens Brain Diseases Signal Transduction Polyomaviridae Data Storage EquipmentMost Recent Publications
Understanding polyomavirus CNS disease – a perspective from mouse models
Katelyn N. Ayers, Sarah N. Carey, Aron E. Lukacher, 2022, FEBS Journal on p. 5744-5761
T cell deficiency precipitates antibody evasion and emergence of neurovirulent polyomavirus
Matthew D. Lauver, Ge Jin, Katelyn N. Ayers, Sarah N. Carey, Charles S. Specht, Catherine S. Abendroth, Aron E. Lukacher, 2022, eLife
New developments implicating IL-21 in autoimmune disease
H Ren, A Lukacher, Rahman ZSM, Nancy Olsen, 2021, Journal of Autoimmunity on p. 102689
Balancing Inflammation and Central Nervous System Homeostasis: T Cell Receptor Signaling in Antiviral Brain T<sub>RM</sub> Formation and Function
Colleen S. Netherby-Winslow, Katelyn N. Ayers, Aron E. Lukacher, 2021, Frontiers in Immunology
JCPyV VP1 Mutations in Progressive Multifocal Leukoencephalopathy: Altering Tropism or Mediating Immune Evasion?
Matthew D. Lauver, Aron E. Lukacher, 2020, Viruses
Il-21 in homeostasis of resident memory and exhausted cd8 t cells during persistent infection
Heather M. Ren, Aron E. Lukacher, 2020, International Journal of Molecular Sciences on p. 1-16
Antibody escape by polyomavirus capsid mutation facilitates neurovirulence
Matthew D. Lauver, Daniel J. Goetschius, Colleen S. Netherby-Winslow, Katelyn N. Ayers, Ge Jin, Daniel G. Haas, Elizabeth L. Frost, Sung Hyun Cho, Carol M. Bator, Stephanie M. Bywaters, Neil D. Christensen, Susan L. Hafenstein, Aron E. Lukacher, 2020, eLife on p. 1-68
IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection
Heather M. Ren, Elizabeth M. Kolawole, Mingqiang Ren, Ge Jin, Colleen S. Netherby-Winslow, Quinn Wade, Shwetank, Ziaur S.M. Rahman, Brian D. Evavold, Aron E. Lukacher, 2020, Science immunology
Serine phosphorylation of the STAT1 transactivation domain promotes autoreactive B cell and systemic autoimmunity development
Sathi Babu Chodisetti, Adam J. Fike, Phillip P. Domeier, Stephanie L. Schell, Taryn E. Mockus, Nicholas M. Choi, Chelsea Corradetti, Baidong Hou, Hannah M. Atkins, Roberto Caricchio, Thomas Decker, Aron E. Lukacher, Nancy Olsen, Ziaur S.M. Rahman, 2020, Journal of Immunology on p. 2641-2650
CD8 T cells and STAT1 signaling are essential codeterminants in protection from polyomavirus encephalopathy
Taryn E. Mockus, Colleen S. Netherby-Winslow, Hannah M. Atkins, Matthew D. Lauver, Ge Jin, Heather M. Ren, Aron E. Lukacher, 2020, Journal of Virology
Most-Cited Papers
Cutting edge: Resident memory CD8 T cells express high-affinity TCRs
Elizabeth L. Frost, Anna E. Kersh, Brian D. Evavold, Aron E. Lukacher, 2015, Journal of Immunology on p. 3520-3524
Maintenance of PD-1 on brain-resident memory CD8 T cells is antigen independent
Shwetank, Hossam A. Abdelsamed, Elizabeth L. Frost, Heather M. Schmitz, Taryn E. Mockus, Ben A. Youngblood, Aron E. Lukacher, 2017, Immunology and Cell Biology on p. 953-959
IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection
Heather M. Ren, Elizabeth M. Kolawole, Mingqiang Ren, Ge Jin, Colleen S. Netherby-Winslow, Quinn Wade, Shwetank, Ziaur S.M. Rahman, Brian D. Evavold, Aron E. Lukacher, 2020, Science immunology
TCR stimulation strength is inversely associated with establishment of functional brain-resident memory CD8 T cells during persistent viral infection
Saumya Maru, Ge Jin, Todd D. Schell, Aron E. Lukacher, 2017, PLoS Pathogens on p. e1006318
CD4 T cells control development and maintenance of brain-resident CD8 T cells during polyomavirus infection
Taryn E. Mockus, Shwetank, Matthew D. Lauver, Heather M. Ren, Colleen S. Netherby, Tarik Salameh, Yuka Imamura Kawasawa, Feng Yue, James R. Broach, Aron E. Lukacher, 2018, PLoS Pathogens
PD-1 dynamically regulates inflammation and development of brain-resident memory CD8 T cells during persistent viral encephalitis
Shwetank, Elizabeth L. Frost, Taryn E. Mockus, Heather M. Ren, Mesut Toprak, Matthew D. Lauver, Colleen S. Netherby-Winslow, Ge Jin, Jennifer M. Cosby, Brian D. Evavold, Aron E. Lukacher, 2019, Frontiers in Immunology
Distinct and synergistic roles of FcγRIIB deficiency and 129 strain-derived SLAM family proteins in the development of spontaneous germinal centers and autoimmunity
Chetna Soni, Phillip P. Domeier, Eric B. Wong, Shwetank, Tahsin N. Khan, Melinda J. Elias, Stephanie L. Schell, Aron E. Lukacher, Timothy K. Cooper, Ziaur S.M. Rahman, 2015, Journal of Autoimmunity on p. 31-46
Inhibition of retrograde transport limits polyomavirus infection in vivo
Saumya Maru, Ge Jin, Dhimant Desai, Shantu Amin, Shwetank, Matthew D. Lauver, Aron E. Lukacher, 2017, mSphere
Pathogen stimulation history impacts donor-specific CD8<sup>+</sup> T cell susceptibility to costimulation/integrin blockade-based therapy
I. R. Badell, W. H. Kitchens, M. E. Wagener, A. E. Lukacher, C. P. Larsen, M. L. Ford, 2015, American Journal of Transplantation on p. 3081-3094
Type I interferons regulate the magnitude and functionality of mouse polyomavirus-specific CD8 T cells in a virus strain- dependent manner
Qingsong Qin, Shwetank, Elizabeth L. Frost, Saumya Maru, Aron E. Lukacher, 2016, Journal of Virology on p. 5187-5199