Aron Lukacher
Professor and Chair of Microbiology & Immunology
Huck Affiliations
Publication Tags
T Lymphocytes Brain Polyomavirus Infection Virus Diseases Infections Interleukin 21 Viruses Polyomavirus Infections Homeostasis Progressive Multifocal Leukoencephalopathy Antibodies Maintenance Jc Virus Autoimmunity B Lymphocytes Germinal Center Cell Differentiation Antigens T Cells Signal Transduction Polyomaviridae Data Storage Equipment Mutation MemoryMost Recent Publications
New developments implicating IL-21 in autoimmune disease.
H Ren, A Lukacher, Rahman ZSM, Nancy Olsen, 2021, Journal of Autoimmunity on p. 102689
Balancing Inflammation and Central Nervous System Homeostasis: T Cell Receptor Signaling in Antiviral Brain T<sub>RM</sub> Formation and Function
Colleen S. Netherby-Winslow, Katelyn N. Ayers, Aron E. Lukacher, 2021, Frontiers in Immunology
Understanding polyomavirus CNS disease – a perspective from mouse models
Katelyn N. Ayers, Sarah N. Carey, Aron E. Lukacher, 2021, FEBS Journal
JCPyV VP1 Mutations in Progressive Multifocal Leukoencephalopathy: Altering Tropism or Mediating Immune Evasion?
Matthew D. Lauver, Aron E. Lukacher, 2020, Viruses
Il-21 in homeostasis of resident memory and exhausted cd8 t cells during persistent infection
Heather M. Ren, Aron E. Lukacher, 2020, International Journal of Molecular Sciences on p. 1-16
Antibody escape by polyomavirus capsid mutation facilitates neurovirulence
Matthew D. Lauver, Daniel J. Goetschius, Colleen S. Netherby-Winslow, Katelyn N. Ayers, Ge Jin, Daniel G. Haas, Elizabeth L. Frost, Sung Hyun Cho, Carol M. Bator, Stephanie M. Bywaters, Neil D. Christensen, Susan L. Hafenstein, Aron E. Lukacher, 2020, eLife on p. 1-68
IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection
Heather M. Ren, Elizabeth M. Kolawole, Mingqiang Ren, Ge Jin, Colleen S. Netherby-Winslow, Quinn Wade, Shwetank, Ziaur S.M. Rahman, Brian D. Evavold, Aron E. Lukacher, 2020, Science immunology
Serine phosphorylation of the STAT1 transactivation domain promotes autoreactive B cell and systemic autoimmunity development
Sathi Babu Chodisetti, Adam J. Fike, Phillip P. Domeier, Stephanie L. Schell, Taryn E. Mockus, Nicholas M. Choi, Chelsea Corradetti, Baidong Hou, Hannah M. Atkins, Roberto Caricchio, Thomas Decker, Aron E. Lukacher, Nancy Olsen, Ziaur S.M. Rahman, 2020, Journal of Immunology on p. 2641-2650
CD8 T cells and STAT1 signaling are essential codeterminants in protection from polyomavirus encephalopathy
Taryn E. Mockus, Colleen S. Netherby-Winslow, Hannah M. Atkins, Matthew D. Lauver, Ge Jin, Heather M. Ren, Aron E. Lukacher, 2020, Journal of Virology
To Go or Stay: The Development, Benefit, and Detriment of Tissue-Resident Memory CD8 T Cells during Central Nervous System Viral Infections
Taryn E. Mockus, Heather M. Ren, Aron E. Lukacher, 2019, Viruses
Most-Cited Papers
Cutting edge: Resident memory CD8 T cells express high-affinity TCRs
Elizabeth L. Frost, Anna E. Kersh, Brian D. Evavold, Aron E. Lukacher, 2015, Journal of Immunology on p. 3520-3524
Maintenance of PD-1 on brain-resident memory CD8 T cells is antigen independent
Shwetank, Hossam A. Abdelsamed, Elizabeth L. Frost, Heather M. Schmitz, Taryn E. Mockus, Ben A. Youngblood, Aron E. Lukacher, 2017, Immunology and Cell Biology on p. 953-959
IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection
Heather M. Ren, Elizabeth M. Kolawole, Mingqiang Ren, Ge Jin, Colleen S. Netherby-Winslow, Quinn Wade, Shwetank, Ziaur S.M. Rahman, Brian D. Evavold, Aron E. Lukacher, 2020, Science immunology
Distinct and synergistic roles of FcγRIIB deficiency and 129 strain-derived SLAM family proteins in the development of spontaneous germinal centers and autoimmunity
Chetna Soni, Phillip P. Domeier, Eric B. Wong, Shwetank, Tahsin N. Khan, Melinda J. Elias, Stephanie L. Schell, Aron E. Lukacher, Timothy K. Cooper, Ziaur S.M. Rahman, 2015, Journal of Autoimmunity on p. 31-46
TCR stimulation strength is inversely associated with establishment of functional brain-resident memory CD8 T cells during persistent viral infection.
Saumya Maru, Ge Jin, Todd D. Schell, Aron E. Lukacher, 2017, PLoS Pathogens on p. e1006318
CD4 T cells control development and maintenance of brain-resident CD8 T cells during polyomavirus infection
Taryn E. Mockus, Shwetank, Matthew D. Lauver, Heather M. Ren, Colleen S. Netherby, Tarik Salameh, Yuka Imamura Kawasawa, Feng Yue, James R. Broach, Aron E. Lukacher, 2018, PLoS Pathogens
PD-1 dynamically regulates inflammation and development of brain-resident memory CD8 T cells during persistent viral encephalitis
Shwetank, Elizabeth L. Frost, Taryn E. Mockus, Heather M. Ren, Mesut Toprak, Matthew D. Lauver, Colleen S. Netherby-Winslow, Ge Jin, Jennifer M. Cosby, Brian D. Evavold, Aron E. Lukacher, 2019, Frontiers in Immunology
CD8 T cells recruited early in mouse polyomavirus infection undergo exhaustion
Jarad J. Wilson, Christopher D. Pack, Eugene Lin, Elizabeth L. Frost, Joshua A. Albrecht, Annette Hadley, Amelia R. Hofstetter, Satvir S. Tevethia, Todd D. Schell, Aron E. Lukacher, 2012, Journal of Immunology on p. 4340-4348
Inhibition of retrograde transport limits polyomavirus infection in vivo
Saumya Maru, Ge Jin, Dhimant Desai, Shantu Amin, Shwetank, Matthew D. Lauver, Aron E. Lukacher, 2017, mSphere
Pathogen stimulation history impacts donor-specific CD8<sup>+</sup> T cell susceptibility to costimulation/integrin blockade-based therapy
I. R. Badell, W. H. Kitchens, M. E. Wagener, A. E. Lukacher, C. P. Larsen, M. L. Ford, 2015, American Journal of Transplantation on p. 3081-3094