Andrew Zydney

Director of the Center for Industrial Biotechnology; Distinguished Professor of Chemical Engineering

Andrew Zydney

Huck Affiliations

Publication Tags

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Membranes Ultrafiltration Fouling Proteins Coloring Agents Textiles Pore Recovery Filtration Pore Size Electrostatics Porosity Dyes Permeability Protein Viruses Microfiltration Water Wastewater Treatment Coulomb Interactions Application Scanning Electron Microscopy Cellulose Wastewater Biological Products

Most Recent Publications

Characterization and associated pressure-dependent behavior of deposits formed during sterile filtration of mRNA-Lipid nanoparticles

Kevork Oliver Messerian, Anton Zverev, Jack F. Kramarczyk, Andrew L. Zydney, 2023, Journal of Membrane Science

Data-science-based reconstruction of 3-D membrane pore structure using a single 2-D micrograph

Hooman Chamani, Arash Rabbani, Kaitlyn P. Russell, Andrew L. Zydney, Enrique D. Gomez, Jason Hattrick-Simpers, Jay R. Werber, 2023, Journal of Membrane Science

Comparison of host cell protein removal by depth filters with diatomaceous earth and synthetic silica filter aids using model proteins

Liang Kai Chu, Ehsan Espah Borujeni, Xuankuo Xu, Sanchayita Ghose, Andrew L. Zydney, 2023, Biotechnology and Bioengineering on p. 1882-1890

Use of scanning electron microscopy and energy dispersive X-ray spectroscopy to identify key fouling species during alternating tangential filtration

Vikram Sundar, Da Zhang, Xianghong Qian, S. Ranil Wickramasinghe, John Paul Smelko, Christina Carbrello, Yara Jabbour Al Maalouf, Andrew L. Zydney, 2023, Biotechnology Progress

Sterile filtration of a multi-serotype glycoconjugate vaccine drug product

Zhuoshi Du, Kanwaldeep Gill, Vishal Toprani, Andrew L. Zydney, 2023, Biotechnology and Bioengineering on p. 1316-1322

Single-Pass Tangential Flow Filtration (SPTFF) of Nanoparticles: Achieving Sustainable Operation with Dilute Colloidal Suspensions for Gene Therapy Applications

Akshay S. Chaubal, Andrew L. Zydney, 2023, Membranes

Impact of virus filter pore size / morphology on virus retention behavior

Kaitlyn P. Russell, Andrew L. Zydney, Enrique Daniel Gomez, 2023, Journal of Membrane Science

Continuous precipitation-filtration process for initial capture of a monoclonal antibody product using a four-stage countercurrent hollow fiber membrane washing step

Mirko Minervini, Matthew Mergy, Yuncan Zhu, Mario A. Gutierrez Diaz, Craig Pointer, Oleg Shinkazh, Sheldon F. Oppenheim, Steven M. Cramer, Todd M. Przybycien, Andrew L. Zydney, 2023, Biotechnology and Bioengineering

Protein fouling during constant-flux virus filtration: Mechanisms and modeling

Joshua Peles, Benjamin Cacace, Christina Carbrello, Sal Giglia, Andrew L. Zydney, 2023, Biotechnology and Bioengineering

High-performance countercurrent membrane purification for host cell protein removal from monoclonal antibody products

Aylin Mohammadzadehmarandi, Amy Determan, Christian Krumm, Lucas D. McIntosh, Andrew L. Zydney, 2023, Biotechnology and Bioengineering

Most-Cited Papers

Tight ultrafiltration membranes for enhanced separation of dyes and Na<sub>2</sub>SO<sub>4</sub> during textile wastewater treatment

Jiuyang Lin, Wenyuan Ye, Marian Cornel Baltaru, Yu Pan Tang, Nicole J. Bernstein, Peng Gao, Stefan Balta, Maria Vlad, Alexander Volodin, Arcadio Sotto, Patricia Luis, Andrew L. Zydney, Bart Van der Bruggen, 2016, Journal of Membrane Science on p. 217-228

Polyacrylamide degradation and its implications in environmental systems

Boya Xiong, Rebeca Loss, Derrick Shields, Taylor Pawlik, Richard Hochreiter, Andrew Zydney, M Kumar, 2018, npj Clean Water

Continuous downstream processing for high value biological products: A Review

Andrew L. Zydney, 2016, Biotechnology and Bioengineering on p. 465-475

Nanoscale control of internal inhomogeneity enhances water transport in desalination membranes

Tyler Culp, Biswajit Khara, Kaitlyn Brickey, Michael Geitner, Tawanda Zimudzi, Jeffrey Wilbur, Steven Jons, Abhishek Roy, Mou Paul, Baskar Ganapathysubramanian, Andrew Zydney, M Kumar, E Gomez, 2021, Science on p. 72-75

Fouling behavior of zwitterionic membranes: Impact of electrostatic and hydrophobic interactions

Mahsa Hadidi, Andrew Zydney, 2014, Journal of Membrane Science on p. 97-103

Ultrafiltration membrane performance: Effects of pore blockage/constriction

Yuriy S. Polyakov, Andrew L. Zydney, 2013, Journal of Membrane Science on p. 106-120

Microfiltration and ultrafiltration: Principles and applications

Leos J. Zeman, Andrew L. Zydney, 2017,

Perspectives on integrated continuous bioprocessing - opportunities and challenges

Andrew Zydney, 2015, Current Opinion in Chemical Engineering on p. 8-13

Fouling of microfiltration membranes by flowback and produced waters from the Marcellus shale gas play

Boya Xiong, Andrew L. Zydney, Manish Kumar, 2016, Water Research on p. 162-170

Recovery of small dye molecules from aqueous solutions using charged ultrafiltration membranes

Xiuwen Chen, Yiru Zhao, Jennifer Moutinho, Jiahui Shao, Andrew L. Zydney, Yiliang He, 2015, Journal of Hazardous Materials on p. 58-64

News Articles Featuring Andrew Zydney

Nov 18, 2022

Engineering community mourns death of Professor Janna Maranas

The Penn State College of Engineering community is mourning the sudden loss of Janna Maranas, professor of chemical engineering, who died on Nov. 3 at the age of 57.

Full Article

Aug 26, 2021

What Chemical Engineers Do and How to Become One

Chemical engineering jobs focus on making chemistry-based products safely, quickly and inexpensively.

Full Article

Aug 23, 2021

Here and Now: Hayes Ready to Lead Center of Excellence in Industrial Biotechnology into the Next Phase of Impact

Dan Hayes, Ph.D., replaced Andrew Zydney, Ph.D., as the Center of Excellence in Industrial Biotechnology's Director.

Full Article

Feb 17, 2021

New Technique Developed for Large-Scale Continuous Protein Purification

Scientists have developed a new technique for purifying proteins during antibody manufacturing. The aim is to reduce the cost of continuous manufacturing for large-scale applications, such as COVID-19 therapeutics or Alzheimer’s disease treatments, without the need for Protein A.

Full Article

Nov 17, 2020

Bioprocessing’s Potential Impact on Patients

To check the pulse of an industry, it never hurts to simply ask around. So, I contacted a collection of bioprocessing experts from around the world, and asked them one question: What is today’s biggest challenge in bioprocessing?

Full Article

Oct 28, 2020

Observing the Performance of Planova Filters

The bioprocessing of therapeutics requires many steps, including viral filtration. To improve these steps, scientists must compare the performance of various products. That’s just what Andrew Zydney, director of the Center of Excellence in Industrial Biotechnology at Pennsylvania State University, and his colleagues did.

Full Article

Oct 19, 2020

Andrew Zydney Shares Continuous Bioprocessing Strategies with a Global Audience

Andrew Zydney, Ph.D., continued sharing his knowledge of bioprocessing with a global audience when he recently spoke at the “BioProcess International” Conference, held virtually for the first time in 2020.

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Feb 25, 2020

Chemical engineering professor receives membrane research award

The North American Membrane Society (NAMS) has named Andrew Zydney, Penn State Bayard D. Kunkle Chair, professor of chemical engineering and director of the Center of Excellence in Industrial Biotechnology, as their 2020 recipient of the Alan S. Michaels Award for Innovation in Membrane Science and Technology.

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Nov 25, 2019

Industrial Biotechnology Scholarships Announced

The Center of Excellence in Industrial Biotechnology is excited to announce two new CSL Behring Scholarships for Penn State undergraduate students interested in the broad area of industrial biotechnology, ranging from biopharmaceutical manufacturing and food biotechnology, to the production of bio-based chemicals.

Full Article