Andrew Zydney
Director of the Center for Industrial Biotechnology; Distinguished Professor of Chemical Engineering

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0041 Greenberg
University Park, PA - alz3@psu.edu
- 814-863-7113
Huck Affiliations
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Membranes Ultrafiltration Fouling Proteins Coloring Agents Textiles Pore Recovery Filtration Pore Size Electrostatics Porosity Dyes Permeability Protein Viruses Microfiltration Water Wastewater Treatment Coulomb Interactions Application Scanning Electron Microscopy Cellulose Wastewater Biological ProductsMost Recent Publications
Characterization and associated pressure-dependent behavior of deposits formed during sterile filtration of mRNA-Lipid nanoparticles
Kevork Oliver Messerian, Anton Zverev, Jack F. Kramarczyk, Andrew L. Zydney, 2023, Journal of Membrane Science
Data-science-based reconstruction of 3-D membrane pore structure using a single 2-D micrograph
Hooman Chamani, Arash Rabbani, Kaitlyn P. Russell, Andrew L. Zydney, Enrique D. Gomez, Jason Hattrick-Simpers, Jay R. Werber, 2023, Journal of Membrane Science
Comparison of host cell protein removal by depth filters with diatomaceous earth and synthetic silica filter aids using model proteins
Liang Kai Chu, Ehsan Espah Borujeni, Xuankuo Xu, Sanchayita Ghose, Andrew L. Zydney, 2023, Biotechnology and Bioengineering on p. 1882-1890
Use of scanning electron microscopy and energy dispersive X-ray spectroscopy to identify key fouling species during alternating tangential filtration
Vikram Sundar, Da Zhang, Xianghong Qian, S. Ranil Wickramasinghe, John Paul Smelko, Christina Carbrello, Yara Jabbour Al Maalouf, Andrew L. Zydney, 2023, Biotechnology Progress
Sterile filtration of a multi-serotype glycoconjugate vaccine drug product
Zhuoshi Du, Kanwaldeep Gill, Vishal Toprani, Andrew L. Zydney, 2023, Biotechnology and Bioengineering on p. 1316-1322
Single-Pass Tangential Flow Filtration (SPTFF) of Nanoparticles: Achieving Sustainable Operation with Dilute Colloidal Suspensions for Gene Therapy Applications
Akshay S. Chaubal, Andrew L. Zydney, 2023, Membranes
Impact of virus filter pore size / morphology on virus retention behavior
Kaitlyn P. Russell, Andrew L. Zydney, Enrique Daniel Gomez, 2023, Journal of Membrane Science
Continuous precipitation-filtration process for initial capture of a monoclonal antibody product using a four-stage countercurrent hollow fiber membrane washing step
Mirko Minervini, Matthew Mergy, Yuncan Zhu, Mario A. Gutierrez Diaz, Craig Pointer, Oleg Shinkazh, Sheldon F. Oppenheim, Steven M. Cramer, Todd M. Przybycien, Andrew L. Zydney, 2023, Biotechnology and Bioengineering
Protein fouling during constant-flux virus filtration: Mechanisms and modeling
Joshua Peles, Benjamin Cacace, Christina Carbrello, Sal Giglia, Andrew L. Zydney, 2023, Biotechnology and Bioengineering
High-performance countercurrent membrane purification for host cell protein removal from monoclonal antibody products
Aylin Mohammadzadehmarandi, Amy Determan, Christian Krumm, Lucas D. McIntosh, Andrew L. Zydney, 2023, Biotechnology and Bioengineering
Most-Cited Papers
Tight ultrafiltration membranes for enhanced separation of dyes and Na<sub>2</sub>SO<sub>4</sub> during textile wastewater treatment
Jiuyang Lin, Wenyuan Ye, Marian Cornel Baltaru, Yu Pan Tang, Nicole J. Bernstein, Peng Gao, Stefan Balta, Maria Vlad, Alexander Volodin, Arcadio Sotto, Patricia Luis, Andrew L. Zydney, Bart Van der Bruggen, 2016, Journal of Membrane Science on p. 217-228
Polyacrylamide degradation and its implications in environmental systems
Boya Xiong, Rebeca Loss, Derrick Shields, Taylor Pawlik, Richard Hochreiter, Andrew Zydney, M Kumar, 2018, npj Clean Water
Continuous downstream processing for high value biological products: A Review
Andrew L. Zydney, 2016, Biotechnology and Bioengineering on p. 465-475
Nanoscale control of internal inhomogeneity enhances water transport in desalination membranes
Tyler Culp, Biswajit Khara, Kaitlyn Brickey, Michael Geitner, Tawanda Zimudzi, Jeffrey Wilbur, Steven Jons, Abhishek Roy, Mou Paul, Baskar Ganapathysubramanian, Andrew Zydney, M Kumar, E Gomez, 2021, Science on p. 72-75
Fouling behavior of zwitterionic membranes: Impact of electrostatic and hydrophobic interactions
Mahsa Hadidi, Andrew Zydney, 2014, Journal of Membrane Science on p. 97-103
Ultrafiltration membrane performance: Effects of pore blockage/constriction
Yuriy S. Polyakov, Andrew L. Zydney, 2013, Journal of Membrane Science on p. 106-120
Microfiltration and ultrafiltration: Principles and applications
Leos J. Zeman, Andrew L. Zydney, 2017,
Perspectives on integrated continuous bioprocessing - opportunities and challenges
Andrew Zydney, 2015, Current Opinion in Chemical Engineering on p. 8-13
Fouling of microfiltration membranes by flowback and produced waters from the Marcellus shale gas play
Boya Xiong, Andrew L. Zydney, Manish Kumar, 2016, Water Research on p. 162-170
Recovery of small dye molecules from aqueous solutions using charged ultrafiltration membranes
Xiuwen Chen, Yiru Zhao, Jennifer Moutinho, Jiahui Shao, Andrew L. Zydney, Yiliang He, 2015, Journal of Hazardous Materials on p. 58-64
News Articles Featuring Andrew Zydney
Nov 18, 2022
Engineering community mourns death of Professor Janna Maranas
The Penn State College of Engineering community is mourning the sudden loss of Janna Maranas, professor of chemical engineering, who died on Nov. 3 at the age of 57.
Full Article
Aug 26, 2021
What Chemical Engineers Do and How to Become One
Chemical engineering jobs focus on making chemistry-based products safely, quickly and inexpensively.
Full Article
Aug 23, 2021
Here and Now: Hayes Ready to Lead Center of Excellence in Industrial Biotechnology into the Next Phase of Impact
Dan Hayes, Ph.D., replaced Andrew Zydney, Ph.D., as the Center of Excellence in Industrial Biotechnology's Director.
Full Article
Feb 17, 2021
New Technique Developed for Large-Scale Continuous Protein Purification
Scientists have developed a new technique for purifying proteins during antibody manufacturing. The aim is to reduce the cost of continuous manufacturing for large-scale applications, such as COVID-19 therapeutics or Alzheimer’s disease treatments, without the need for Protein A.
Full Article
Nov 17, 2020
Bioprocessing’s Potential Impact on Patients
To check the pulse of an industry, it never hurts to simply ask around. So, I contacted a collection of bioprocessing experts from around the world, and asked them one question: What is today’s biggest challenge in bioprocessing?
Full Article
Oct 28, 2020
Observing the Performance of Planova Filters
The bioprocessing of therapeutics requires many steps, including viral filtration. To improve these steps, scientists must compare the performance of various products. That’s just what Andrew Zydney, director of the Center of Excellence in Industrial Biotechnology at Pennsylvania State University, and his colleagues did.
Full Article
Oct 19, 2020
Andrew Zydney Shares Continuous Bioprocessing Strategies with a Global Audience
Andrew Zydney, Ph.D., continued sharing his knowledge of bioprocessing with a global audience when he recently spoke at the “BioProcess International” Conference, held virtually for the first time in 2020.
Full Article
Feb 25, 2020
Chemical engineering professor receives membrane research award
The North American Membrane Society (NAMS) has named Andrew Zydney, Penn State Bayard D. Kunkle Chair, professor of chemical engineering and director of the Center of Excellence in Industrial Biotechnology, as their 2020 recipient of the Alan S. Michaels Award for Innovation in Membrane Science and Technology.
Full Article
Nov 25, 2019
Industrial Biotechnology Scholarships Announced
The Center of Excellence in Industrial Biotechnology is excited to announce two new CSL Behring Scholarships for Penn State undergraduate students interested in the broad area of industrial biotechnology, ranging from biopharmaceutical manufacturing and food biotechnology, to the production of bio-based chemicals.
Full Article