Andrew Zydney
Director of the Center for Industrial Biotechnology; Distinguished Professor of Chemical Engineering
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0041 Greenberg
University Park, PA - alz3@psu.edu
- 814-863-7113
Huck Affiliations
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Membranes Ultrafiltration Fouling Proteins Textiles Coloring Agents Recovery Degradation Water Electrostatics Hydraulic Fracturing Microfiltration Dyes Wastewater Treatment Water Treatment Shale Wastewater Salts Shale Gas Protein Coulomb Interactions Chromatography Dye Water Conservation Biological ProductsMost Recent Publications
Optimizing particle morphology during antibody precipitation for enhanced tangential flow filtration performance
Mirko Minervini, Ali Behboudi, Jovana R. Marzella, Andrew L. Zydney, 2024, Gas Separation and Purification
Tangential flow filtration for continuous processing of crystallized proteins
Ali Behboudi, Mirko Minervini, Alexander Kedzierski, Lawrence Azzariti, Andrew L. Zydney, 2024, Gas Separation and Purification
Filtration of a multi-serotype glycoconjugate vaccine drug product through sterilizing grade 0.2/0.22 µm pore size filters
Zhuoshi Du, Siyi Qiu, Kanwal Gill, Vishal Toprani, Andrew L. Zydney, 2024, Biotechnology Journal
Membrane technology for the purification of RNA and DNA therapeutics
Amin Javidanbardan, Kevork Oliver Messerian, Andrew L. Zydney, 2024, Trends in Biotechnology
Challenges & opportunities in sterile filtration of vaccines
Kevork Messerian, Zhuoshi Du, Neil Taylor, Andrew Zydney, 2023, Vaccine Insights on p. 475-483
The role of intermolecular interactions on monoclonal antibody filtration through virus removal membranes
Matthew Billups, Mirko Minervini, Melissa Holstein, Hasin Feroz, Swarnim Ranjan, Jessica Hung, Andrew L. Zydney, 2023, Biotechnology Journal
High-performance countercurrent membrane purification for host cell protein removal from monoclonal antibody products
Aylin Mohammadzadehmarandi, Amy Determan, Christian Krumm, Lucas D. McIntosh, Andrew L. Zydney, 2023, Biotechnology and Bioengineering on p. 3585-3591
Protein fouling during constant-flux virus filtration: Mechanisms and modeling
Joshua Peles, Benjamin Cacace, Christina Carbrello, Sal Giglia, Andrew L. Zydney, 2023, Biotechnology and Bioengineering on p. 3357-3367
Characterization and associated pressure-dependent behavior of deposits formed during sterile filtration of mRNA-Lipid nanoparticles
Kevork Oliver Messerian, Anton Zverev, Jack F. Kramarczyk, Andrew L. Zydney, 2023, Journal of Membrane Science
Smart Manufacturing Implementation of a Continuous Downstream Precipitation and Filtration Process for Antibody Purification
Sambit Ghosh, Matthew Mergy, Mirko Minervini, Jacinta Okpanum, Steven M. Cramer, B. Wayne Bequette, Andrew L. Zydney, Todd M. Przybycien, 2023, Smart and Sustainable Manufacturing Systems on p. 129-147
Most-Cited Papers
Tight ultrafiltration membranes for enhanced separation of dyes and Na<sub>2</sub>SO<sub>4</sub> during textile wastewater treatment
Jiuyang Lin, Wenyuan Ye, Marian Cornel Baltaru, Yu Pan Tang, Nicole J. Bernstein, Peng Gao, Stefan Balta, Maria Vlad, Alexander Volodin, Arcadio Sotto, Patricia Luis, Andrew L. Zydney, Bart Van der Bruggen, 2016, Journal of Membrane Science on p. 217-228
Polyacrylamide degradation and its implications in environmental systems
Boya Xiong, Rebeca Loss, Derrick Shields, Taylor Pawlik, Richard Hochreiter, Andrew Zydney, M Kumar, 2018, npj Clean Water
Continuous downstream processing for high value biological products: A Review
Andrew L. Zydney, 2016, Biotechnology and Bioengineering on p. 465-475
Nanoscale control of internal inhomogeneity enhances water transport in desalination membranes
Tyler Culp, Biswajit Khara, Kaitlyn Brickey, Michael Geitner, Tawanda Zimudzi, Jeffrey Wilbur, Steven Jons, Abhishek Roy, Mou Paul, Baskar Ganapathysubramanian, Andrew Zydney, M Kumar, E Gomez, 2021, Science on p. 72-75
Fouling behavior of zwitterionic membranes: Impact of electrostatic and hydrophobic interactions
Mahsa Hadidi, Andrew Zydney, 2014, Journal of Membrane Science on p. 97-103
Microfiltration and ultrafiltration: Principles and applications
Leos J. Zeman, Andrew L. Zydney, 2017,
Perspectives on integrated continuous bioprocessing - opportunities and challenges
Andrew Zydney, 2015, Current Opinion in Chemical Engineering on p. 8-13
Fouling of microfiltration membranes by flowback and produced waters from the Marcellus shale gas play
Boya Xiong, Andrew L. Zydney, Manish Kumar, 2016, Water Research on p. 162-170
Chemical Degradation of Polyacrylamide during Hydraulic Fracturing
Boya Xiong, Zachary Miller, Selina Roman-White, Travis Tasker, Benjamin Farina, Bethany Piechowicz, William D. Burgos, Prachi Joshi, Liang Zhu, Christopher A. Gorski, Andrew L. Zydney, Manish Kumar, 2018, Environmental Science & Technology on p. 327-336
Recovery of small dye molecules from aqueous solutions using charged ultrafiltration membranes
Xiuwen Chen, Yiru Zhao, Jennifer Moutinho, Jiahui Shao, Andrew L. Zydney, Yiliang He, 2015, Journal of Hazardous Materials on p. 58-64
News Articles Featuring Andrew Zydney
Nov 18, 2022
Engineering community mourns death of Professor Janna Maranas
The Penn State College of Engineering community is mourning the sudden loss of Janna Maranas, professor of chemical engineering, who died on Nov. 3 at the age of 57.
Full Article
Aug 26, 2021
What Chemical Engineers Do and How to Become One
Chemical engineering jobs focus on making chemistry-based products safely, quickly and inexpensively.
Full Article
Aug 23, 2021
Here and Now: Hayes Ready to Lead Center of Excellence in Industrial Biotechnology into the Next Phase of Impact
Dan Hayes, Ph.D., replaced Andrew Zydney, Ph.D., as the Center of Excellence in Industrial Biotechnology's Director.
Full Article
Feb 17, 2021
New Technique Developed for Large-Scale Continuous Protein Purification
Scientists have developed a new technique for purifying proteins during antibody manufacturing. The aim is to reduce the cost of continuous manufacturing for large-scale applications, such as COVID-19 therapeutics or Alzheimer’s disease treatments, without the need for Protein A.
Full Article
Nov 17, 2020
Bioprocessing’s Potential Impact on Patients
To check the pulse of an industry, it never hurts to simply ask around. So, I contacted a collection of bioprocessing experts from around the world, and asked them one question: What is today’s biggest challenge in bioprocessing?
Full Article
Oct 28, 2020
Observing the Performance of Planova Filters
The bioprocessing of therapeutics requires many steps, including viral filtration. To improve these steps, scientists must compare the performance of various products. That’s just what Andrew Zydney, director of the Center of Excellence in Industrial Biotechnology at Pennsylvania State University, and his colleagues did.
Full Article
Oct 19, 2020
Andrew Zydney Shares Continuous Bioprocessing Strategies with a Global Audience
Andrew Zydney, Ph.D., continued sharing his knowledge of bioprocessing with a global audience when he recently spoke at the “BioProcess International” Conference, held virtually for the first time in 2020.
Full Article
Feb 25, 2020
Chemical engineering professor receives membrane research award
The North American Membrane Society (NAMS) has named Andrew Zydney, Penn State Bayard D. Kunkle Chair, professor of chemical engineering and director of the Center of Excellence in Industrial Biotechnology, as their 2020 recipient of the Alan S. Michaels Award for Innovation in Membrane Science and Technology.
Full Article
Nov 25, 2019
Industrial Biotechnology Scholarships Announced
The Center of Excellence in Industrial Biotechnology is excited to announce two new CSL Behring Scholarships for Penn State undergraduate students interested in the broad area of industrial biotechnology, ranging from biopharmaceutical manufacturing and food biotechnology, to the production of bio-based chemicals.
Full Article