Andrew Zydney

Director of the Center for Industrial Biotechnology; Distinguished Professor of Chemical Engineering


Andrew Zydney

Huck Affiliations

Most Recent Publications

Vibration-Assisted Single-Pass tangential flow filtration for processing precipitated proteins

Km Prottoy Shariar Piash, Claire MacElroy, Ziqiao Wang, Andrew L. Zydney, 2025, Gas Separation and Purification

Impact of hollow fiber length and inner diameter on critical flux and conversion during single-pass tangential flow filtration of precipitated IgG

Niloufar Rezaei, Goli Ghajar, Andrew L. Zydney, 2025, Gas Separation and Purification

Modeling transitional fouling mechanisms for mRNA-lipid nanoparticles during sterile filtration

Kevork Oliver Messerian, Anton Zverev, Jack F. Kramarczyk, Andrew L. Zydney, 2025, Journal of Membrane Science

Single pass tangential flow filtration (SPTFF) for concentration and purification of AAV clarified cell lysate

Akshay S. Chaubal, Christopher J. Yehl, Mohammad A. Afzal, Lu Wang, Andrew L. Zydney, 2025, Journal of Membrane Science

Vibration-assisted ultrafiltration dramatically improves mRNA purification

Ali Behboudi, Amin Javidanbardan, Ziqiao Wang, Luolin Zhou, Andrew L. Zydney, 2025, Gas Separation and Purification

Perspectives on sterile filter performance through insights obtained by membrane characterization methods

Shreya Kapila, Kevork Oliver Messerian, Andrew L. Zydney, 2025, Journal of Membrane Science

The application of forward osmosis for producing highly concentrated biotherapeutics

Vasudev Tangry, William Haddad, Ali Behboudi, Andrew L. Zydney, 2025, Journal of Membrane Science

Single-pass tangential flow filtration (SPTFF) for continuous mRNA concentration and purification

Amin Javidanbardan, Ziqiao Wang, Abigail Kostic, Ali Behboudi, Andrew L. Zydney, 2025, Journal of Membrane Science

Enhancing the Performance of Tangential Flow Microfiltration for Bioreactor Clarification

Amir Hossein Mostafavi, Liang Kai Chu, Xianghong Qian, John Paul Smelko, Da Zhang, Andrew Zydney, Sumith Ranil Wickramasinghe, 2025, Membranes

Development of a local wall concentration model for the design of single pass tangential flow filtration (SPTFF) systems with viral vector surrogates

Akshay S. Chaubal, Alexis J. Single, Andrew L. Zydney, 2025, Journal of Membrane Science

Most-Cited Papers

Tight ultrafiltration membranes for enhanced separation of dyes and Na<sub>2</sub>SO<sub>4</sub> during textile wastewater treatment

Jiuyang Lin, Wenyuan Ye, Marian Cornel Baltaru, Yu Pan Tang, Nicole J. Bernstein, Peng Gao, Stefan Balta, Maria Vlad, Alexander Volodin, Arcadio Sotto, Patricia Luis, Andrew L. Zydney, Bart Van der Bruggen, 2016, Journal of Membrane Science on p. 217-228

Polyacrylamide degradation and its implications in environmental systems

Boya Xiong, Rebeca Loss, Derrick Shields, Taylor Pawlik, Richard Hochreiter, Andrew Zydney, M Kumar, 2018, npj Clean Water

Nanoscale control of internal inhomogeneity enhances water transport in desalination membranes

Tyler Culp, Biswajit Khara, Kaitlyn Brickey, Michael Geitner, Tawanda Zimudzi, Jeffrey Wilbur, Steven Jons, Abhishek Roy, Mou Paul, Baskar Ganapathysubramanian, Andrew Zydney, M Kumar, E Gomez, 2021, Science on p. 72-75

Continuous downstream processing for high value biological products: A Review

Andrew L. Zydney, 2016, Biotechnology and Bioengineering on p. 465-475

Microfiltration and ultrafiltration: Principles and applications

Leos J. Zeman, Andrew L. Zydney, 2017,

Perspectives on integrated continuous bioprocessing - opportunities and challenges

Andrew Zydney, 2015, Current Opinion in Chemical Engineering on p. 8-13

Chemical Degradation of Polyacrylamide during Hydraulic Fracturing

Boya Xiong, Zachary Miller, Selina Roman-White, Travis Tasker, Benjamin Farina, Bethany Piechowicz, William D. Burgos, Prachi Joshi, Liang Zhu, Christopher A. Gorski, Andrew L. Zydney, Manish Kumar, 2018, Environmental Science & Technology on p. 327-336

Fouling of microfiltration membranes by flowback and produced waters from the Marcellus shale gas play

Boya Xiong, Andrew L. Zydney, Manish Kumar, 2016, Water Research on p. 162-170

A review of membrane fouling by proteins in ultrafiltration and microfiltration

Henry J. Tanudjaja, Aditya Anantharaman, Angie Qi Qi Ng, Yunqiao Ma, Melike Begüm Tanis-Kanbur, Andrew L. Zydney, Jia Wei Chew, 2022, Journal of Water Process Engineering

New developments in membranes for bioprocessing – A review

Andrew Zydney, 2021, Journal of Membrane Science on p. 118804

News Articles Featuring Andrew Zydney

Nov 08, 2024

Penn State’s chemical engineering program celebrates 100 years

Penn State's chemical engineering program today houses nearly 10,000 alumni, 500 undergraduates and graduate students, as well as 45 faculty, post-doctoral candidates and staff members.

Full Article

Nov 18, 2022

Engineering community mourns death of Professor Janna Maranas

The Penn State College of Engineering community is mourning the sudden loss of Janna Maranas, professor of chemical engineering, who died on Nov. 3 at the age of 57.

Full Article

Aug 26, 2021

What Chemical Engineers Do and How to Become One

Chemical engineering jobs focus on making chemistry-based products safely, quickly and inexpensively.

Full Article

Aug 23, 2021

Here and Now: Hayes Ready to Lead Center of Excellence in Industrial Biotechnology into the Next Phase of Impact

Dan Hayes, Ph.D., replaced Andrew Zydney, Ph.D., as the Center of Excellence in Industrial Biotechnology's Director.

Full Article

Feb 17, 2021

New Technique Developed for Large-Scale Continuous Protein Purification

Scientists have developed a new technique for purifying proteins during antibody manufacturing. The aim is to reduce the cost of continuous manufacturing for large-scale applications, such as COVID-19 therapeutics or Alzheimer’s disease treatments, without the need for Protein A.

Full Article

Nov 17, 2020

Bioprocessing’s Potential Impact on Patients

To check the pulse of an industry, it never hurts to simply ask around. So, I contacted a collection of bioprocessing experts from around the world, and asked them one question: What is today’s biggest challenge in bioprocessing?

Full Article

Oct 28, 2020

Observing the Performance of Planova Filters

The bioprocessing of therapeutics requires many steps, including viral filtration. To improve these steps, scientists must compare the performance of various products. That’s just what Andrew Zydney, director of the Center of Excellence in Industrial Biotechnology at Pennsylvania State University, and his colleagues did.

Full Article

Oct 19, 2020

Andrew Zydney Shares Continuous Bioprocessing Strategies with a Global Audience

Andrew Zydney, Ph.D., continued sharing his knowledge of bioprocessing with a global audience when he recently spoke at the “BioProcess International” Conference, held virtually for the first time in 2020.

Full Article

Feb 25, 2020

Chemical engineering professor receives membrane research award

The North American Membrane Society (NAMS) has named Andrew Zydney, Penn State Bayard D. Kunkle Chair, professor of chemical engineering and director of the Center of Excellence in Industrial Biotechnology, as their 2020 recipient of the Alan S. Michaels Award for Innovation in Membrane Science and Technology.

Full Article

Nov 25, 2019

Industrial Biotechnology Scholarships Announced

The Center of Excellence in Industrial Biotechnology is excited to announce two new CSL Behring Scholarships for Penn State undergraduate students interested in the broad area of industrial biotechnology, ranging from biopharmaceutical manufacturing and food biotechnology, to the production of bio-based chemicals.

Full Article