Andrew Zydney

Director of the Center for Industrial Biotechnology; Distinguished Professor of Chemical Engineering

Andrew Zydney

Huck Affiliations

Publication Tags

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Membranes Ultrafiltration Fouling Proteins Textiles Coloring Agents Recovery Degradation Water Electrostatics Hydraulic Fracturing Microfiltration Dyes Wastewater Treatment Water Treatment Shale Wastewater Salts Shale Gas Protein Coulomb Interactions Chromatography Dye Water Conservation Biological Products

Most Recent Publications

Optimizing particle morphology during antibody precipitation for enhanced tangential flow filtration performance

Mirko Minervini, Ali Behboudi, Jovana R. Marzella, Andrew L. Zydney, 2024, Gas Separation and Purification

Tangential flow filtration for continuous processing of crystallized proteins

Ali Behboudi, Mirko Minervini, Alexander Kedzierski, Lawrence Azzariti, Andrew L. Zydney, 2024, Gas Separation and Purification

Filtration of a multi-serotype glycoconjugate vaccine drug product through sterilizing grade 0.2/0.22 µm pore size filters

Zhuoshi Du, Siyi Qiu, Kanwal Gill, Vishal Toprani, Andrew L. Zydney, 2024, Biotechnology Journal

Proteomic analysis of host cell protein fouling during bioreactor harvesting

Da Zhang, S. Ranil Wickramasinghe, Andrew L. Zydney, John P. Smelko, Abdullah Loman, April Wheeler, Xianghong Qian, 2024, Biotechnology Progress

Membrane technology for the purification of RNA and DNA therapeutics

Amin Javidanbardan, Kevork Oliver Messerian, Andrew L. Zydney, 2024, Trends in Biotechnology

Challenges & opportunities in sterile filtration of vaccines

Kevork Messerian, Zhuoshi Du, Neil Taylor, Andrew Zydney, 2023, Vaccine Insights on p. 475-483

The role of intermolecular interactions on monoclonal antibody filtration through virus removal membranes

Matthew Billups, Mirko Minervini, Melissa Holstein, Hasin Feroz, Swarnim Ranjan, Jessica Hung, Andrew L. Zydney, 2023, Biotechnology Journal

High-performance countercurrent membrane purification for host cell protein removal from monoclonal antibody products

Aylin Mohammadzadehmarandi, Amy Determan, Christian Krumm, Lucas D. McIntosh, Andrew L. Zydney, 2023, Biotechnology and Bioengineering on p. 3585-3591

Protein fouling during constant-flux virus filtration: Mechanisms and modeling

Joshua Peles, Benjamin Cacace, Christina Carbrello, Sal Giglia, Andrew L. Zydney, 2023, Biotechnology and Bioengineering on p. 3357-3367

Characterization and associated pressure-dependent behavior of deposits formed during sterile filtration of mRNA-Lipid nanoparticles

Kevork Oliver Messerian, Anton Zverev, Jack F. Kramarczyk, Andrew L. Zydney, 2023, Journal of Membrane Science

Most-Cited Papers

Tight ultrafiltration membranes for enhanced separation of dyes and Na<sub>2</sub>SO<sub>4</sub> during textile wastewater treatment

Jiuyang Lin, Wenyuan Ye, Marian Cornel Baltaru, Yu Pan Tang, Nicole J. Bernstein, Peng Gao, Stefan Balta, Maria Vlad, Alexander Volodin, Arcadio Sotto, Patricia Luis, Andrew L. Zydney, Bart Van der Bruggen, 2016, Journal of Membrane Science on p. 217-228

Polyacrylamide degradation and its implications in environmental systems

Boya Xiong, Rebeca Loss, Derrick Shields, Taylor Pawlik, Richard Hochreiter, Andrew Zydney, M Kumar, 2018, npj Clean Water

Continuous downstream processing for high value biological products: A Review

Andrew L. Zydney, 2016, Biotechnology and Bioengineering on p. 465-475

Nanoscale control of internal inhomogeneity enhances water transport in desalination membranes

Tyler Culp, Biswajit Khara, Kaitlyn Brickey, Michael Geitner, Tawanda Zimudzi, Jeffrey Wilbur, Steven Jons, Abhishek Roy, Mou Paul, Baskar Ganapathysubramanian, Andrew Zydney, M Kumar, E Gomez, 2021, Science on p. 72-75

Fouling behavior of zwitterionic membranes: Impact of electrostatic and hydrophobic interactions

Mahsa Hadidi, Andrew Zydney, 2014, Journal of Membrane Science on p. 97-103

Microfiltration and ultrafiltration: Principles and applications

Leos J. Zeman, Andrew L. Zydney, 2017,

Perspectives on integrated continuous bioprocessing - opportunities and challenges

Andrew Zydney, 2015, Current Opinion in Chemical Engineering on p. 8-13

Fouling of microfiltration membranes by flowback and produced waters from the Marcellus shale gas play

Boya Xiong, Andrew L. Zydney, Manish Kumar, 2016, Water Research on p. 162-170

Chemical Degradation of Polyacrylamide during Hydraulic Fracturing

Boya Xiong, Zachary Miller, Selina Roman-White, Travis Tasker, Benjamin Farina, Bethany Piechowicz, William D. Burgos, Prachi Joshi, Liang Zhu, Christopher A. Gorski, Andrew L. Zydney, Manish Kumar, 2018, Environmental Science & Technology on p. 327-336

Recovery of small dye molecules from aqueous solutions using charged ultrafiltration membranes

Xiuwen Chen, Yiru Zhao, Jennifer Moutinho, Jiahui Shao, Andrew L. Zydney, Yiliang He, 2015, Journal of Hazardous Materials on p. 58-64

News Articles Featuring Andrew Zydney

Nov 18, 2022

Engineering community mourns death of Professor Janna Maranas

The Penn State College of Engineering community is mourning the sudden loss of Janna Maranas, professor of chemical engineering, who died on Nov. 3 at the age of 57.

Full Article

Aug 26, 2021

What Chemical Engineers Do and How to Become One

Chemical engineering jobs focus on making chemistry-based products safely, quickly and inexpensively.

Full Article

Aug 23, 2021

Here and Now: Hayes Ready to Lead Center of Excellence in Industrial Biotechnology into the Next Phase of Impact

Dan Hayes, Ph.D., replaced Andrew Zydney, Ph.D., as the Center of Excellence in Industrial Biotechnology's Director.

Full Article

Feb 17, 2021

New Technique Developed for Large-Scale Continuous Protein Purification

Scientists have developed a new technique for purifying proteins during antibody manufacturing. The aim is to reduce the cost of continuous manufacturing for large-scale applications, such as COVID-19 therapeutics or Alzheimer’s disease treatments, without the need for Protein A.

Full Article

Nov 17, 2020

Bioprocessing’s Potential Impact on Patients

To check the pulse of an industry, it never hurts to simply ask around. So, I contacted a collection of bioprocessing experts from around the world, and asked them one question: What is today’s biggest challenge in bioprocessing?

Full Article

Oct 28, 2020

Observing the Performance of Planova Filters

The bioprocessing of therapeutics requires many steps, including viral filtration. To improve these steps, scientists must compare the performance of various products. That’s just what Andrew Zydney, director of the Center of Excellence in Industrial Biotechnology at Pennsylvania State University, and his colleagues did.

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Oct 19, 2020

Andrew Zydney Shares Continuous Bioprocessing Strategies with a Global Audience

Andrew Zydney, Ph.D., continued sharing his knowledge of bioprocessing with a global audience when he recently spoke at the “BioProcess International” Conference, held virtually for the first time in 2020.

Full Article

Feb 25, 2020

Chemical engineering professor receives membrane research award

The North American Membrane Society (NAMS) has named Andrew Zydney, Penn State Bayard D. Kunkle Chair, professor of chemical engineering and director of the Center of Excellence in Industrial Biotechnology, as their 2020 recipient of the Alan S. Michaels Award for Innovation in Membrane Science and Technology.

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Nov 25, 2019

Industrial Biotechnology Scholarships Announced

The Center of Excellence in Industrial Biotechnology is excited to announce two new CSL Behring Scholarships for Penn State undergraduate students interested in the broad area of industrial biotechnology, ranging from biopharmaceutical manufacturing and food biotechnology, to the production of bio-based chemicals.

Full Article