Andrew Read

Director, Huck Institutes of the Life Sciences; Evan Pugh Professor of Biology and Entomology; Eberly Professor of Biotechnology

Andrew Read

Research Summary

The ecology and evolutionary genetics of infectious disease.

Huck Affiliations


Publication Tags

Temperature Drug Resistance Therapeutics Resistance Vaccines Anti Bacterial Agents Culicidae Malaria Neoplasms Daptomycin Pharmaceutical Preparations Pathogens Parasites Ecology Drug Therapy Resistance Management Clinical Trials Bacteria Chemotherapy Population Dynamics Antibiotic Resistance Antimicrobial Agent Enterococcus Faecium Drugs Anopheles

Most Recent Papers

Daptomycin treatment impacts resistance in off-target populations of vancomycin-resistant Enterococcus faecium

Clare L. Kinnear, Elsa Hansen, Valerie J. Morley, Kevin C. Tracy, Meghan Forstchen, Andrew F. Read, Robert J. Woods, 2020, PLoS Biology

Modifying adaptive therapy to enhance competitive suppression

Elsa Hansen, Andrew F. Read, 2020, Cancers on p. 1-13

An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen

Valerie J. Morley, Clare L. Kinnear, Derek G. Sim, Samantha N. Olson, Lindsey M. Jackson, Elsa Hansen, Grace A. Usher, Scott A. Showalter, Manjunath P. Pai, Robert J. Woods, Andrew F. Read, 2020, eLife on p. 1-17

Monitor for COVID-19 vaccine resistance evolution during clinical trials

David A. Kennedy, Andrew F. Read, David A. Kennedy, 2020, PLoS Biology

Cancer therapy: Attempt cure or manage drug resistance?

Elsa Hansen, Andrew F. Read, 2020, Evolutionary Applications on p. 1660-1672

Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations

Elsa Hansen, Jason Karslake, Robert J. Woods, Andrew F. Read, Kevin B. Wood, 2020, PLoS Biology

Susceptibility of Cutibacterium acnes to topical minocycline foam

Joyce Sutcliffe, Robert McLaughlin, Guy Webster, Andrew F. Read, Karl Drlica, Russell Elliott, Iain Stuart, 2020, Anaerobe

Evolutionary consequences of feedbacks between within-host competition and disease control

Megan A. Greischar, Helen K. Alexander, Farrah Bashey, Ana I. Bento, Amrita Bhattacharya, Mary Bushman, Lauren M. Childs, David R. Daversa, Troy Day, Christina L. Faust, Molly E. Gallagher, Sylvain Gandon, Caroline K. Glidden, Fletcher W. Halliday, Kathryn A. Hanley, Tsukushi Kamiya, Andrew F. Read, Philipp Schwabl, Amy R. Sweeny, Ann T. Tate, Robin N. Thompson, Nina Wale, Helen J. Wearing, Pamela J. Yeh, Nicole Mideo, 2020, Evolution, Medicine and Public Health on p. 30-34

Factors associated with antibiotic prescribing for acute bronchitis at a university health center

Valerie J. Morley, Emily P.C. Firgens, Rachel R. Vanderbilt, Yanmengqian Zhou, Michelle Zook, Andrew F. Read, Erina L. MacGeorge, 2020, BMC Infectious Diseases

Identifying key questions in the ecology and evolution of cancer

Antoine M. Dujon, Athena Aktipis, Catherine Alix-Panabières, Sarah R. Amend, Amy M. Boddy, Joel S. Brown, Jean Pascal Capp, James DeGregori, Paul Ewald, Robert Gatenby, Marco Gerlinger, Mathieu Giraudeau, Rodrigo K. Hamede, Elsa Hansen, Irina Kareva, Carlo C. Maley, Andriy Marusyk, Nicholas McGranahan, Michael J. Metzger, Aurora M. Nedelcu, Robert Noble, Leonard Nunney, Kenneth J. Pienta, Kornelia Polyak, Pascal Pujol, Andrew F. Read, Benjamin Roche, Susanne Sebens, Eric Solary, Kateřina Staňková, Holly Swain Ewald, Frédéric Thomas, Beata Ujvari, 2020, Evolutionary Applications on p. 877-892

Most-Cited Papers

The evolution of drug resistance and the curious orthodoxy of aggressive chemotherapy

Andrew F. Read, Troy Day, Silvie Huijben, 2011, Proceedings of the National Academy of Sciences of the United States of America on p. 10871-10877

Imperfect vaccination can enhance the transmission of highly virulent pathogens

Andrew F. Read, Susan J. Baigent, Claire Powers, Lydia B. Kgosana, Luke Blackwell, Lorraine P. Smith, David A. Kennedy, Stephen W. Walkden-Brown, Venugopal K. Nair, 2015, PLoS Biology on p. e1002198

The effect of temperature on Anopheles mosquito population dynamics and the potential for malaria transmission

Lindsay M. Beck-Johnson, William A. Nelson, Krijn P. Paaijmans, Andrew F. Read, Matthew B. Thomas, Ottar N. Bjørnstad, 2013, PLoS One

Malaria in India

Aparup Das, Anupkumar R. Anvikar, Lauren J. Cator, Ramesh C. Dhiman, Alex Eapen, Neelima Mishra, Bhupinder N. Nagpal, Nutan Nanda, Kamaraju Raghavendra, Andrew F. Read, Surya K. Sharma, Om P. Singh, Vineeta Singh, Photini Sinnis, Harish C. Srivastava, Steven A. Sullivan, Patrick L. Sutton, Matthew B. Thomas, Jane M. Carlton, Neena Valecha, 2012, Acta Tropica on p. 267-273

Malaria-induced changes in host odors enhance mosquito attraction

Consuelo M. De Moraes, Nina M. Stanczyk, Heike S. Betz, Hannier Pulido, Derek G. Sim, Andrew F. Read, Mark C. Mescher, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 11079-11084

Complex effects of temperature on mosquito immune function

C. C. Murdock, Krijn P. Paaijmans, Andrew S. Bells, Jonas G. King, Julián F. Hillyer, Andrew F. Read, Matthew B. Thomas, 2012, Proceedings of the Royal Society B: Biological Sciences on p. 3357-3366

Rethinking vector immunology

Courtney C. Murdock, Krijn P. Paaijmans, Diana Cox-Foster, Andrew F. Read, Matthew B. Thomas, 2012, Nature Reviews Microbiology on p. 869-876

Does High-Dose Antimicrobial Chemotherapy Prevent the Evolution of Resistance?

Troy Day, Andrew F. Read, 2016, PLoS Computational Biology

Antibiotic resistance management

Andrew F. Read, Robert J. Woods, 2014, Evolution, Medicine and Public Health on p. 147

Evolutionary history and attenuation of myxoma virus on two continents.

Peter J. Kerr, Elodie Ghedin, Jay V. DePasse, Adam Fitch, Isabella M. Cattadori, Peter J. Hudson, David C. Tscharke, Andrew F. Read, Edward C. Holmes, 2012, PLoS Pathogens

News Articles Featuring Andrew Read

What the Future May Hold for the Coronavirus and Us

Viral evolution is a long game. Here’s where scientists think we could be headed.

‘We Know A Lot More Now’

Nearly two years after the emergence of a pandemic that disrupted life on Earth, Andrew Read, director of the Huck Institutes of the Life Sciences, reflects on what scientists have learned from COVID-19, what the world can expect going forward, and what we should not repeat.

COVID vaccine immunity is waning — how much does that matter?

As debates about booster shots heat up, what’s known about the duration of vaccine-based immunity is still evolving.

Penn State Researcher Says Vaccine-Driven Virus Evolution In Chickens Shouldn't Discourage COVID-19 Vaccination

A research paper published in 2015 showed vaccines could enable more deadly variants of a virus to spread among chickens. Penn State researcher Dr. Andrew Read, who led the study, said the paper has gone viral in recent weeks because readers are misunderstanding it and making unfounded comparisons with COVID-19 vaccines.

The Mu coronavirus variant shares key similarities with Delta, but it doesn't pose a greater threat

Last month, seven fully vaccinated, elderly residents of a nursing home in Belgium died of COVID-19. They had all been infected with a coronavirus variant now known as Mu. The outbreak raised questions about whether Mu posed a greater threat than other variants, including Delta. But so far, that hasn't proven to be the case.

Vaccines could affect how the coronavirus evolves, but that’s no reason to skip your shot

A 2015 paper on a chicken virus showed vaccines could enable more deadly variants to spread—in chickens. But that outcome is rare. Only a minority of human and animal vaccines have affected the evolution of a virus. In most of those cases, evolution didn’t increase the severity of the pathogen.

Vaccines could affect how the coronavirus evolves - but that’s no reason to skip your shot

In 2015, my collaborators and I published a scientific paper about a chicken virus you have likely never heard of. At the time, it got some media attention and has been cited by other scientists in the years since.

Evidence shows that COVID-19 variants are largely spread among unvaccinated people

A Facebook post authored by someone touting toxicology credentials joined the growing field of inaccurate claims that falsely blame the vaccine for a pandemic that has stretched into a second year.

Author of 2015 vaccine study 'terrified' his work is being misinterpreted

Penn State study examining the dangers of chicken vaccines has gone viral, fueling misconceptions about COVID-19 vaccines.

New SARS-CoV-2 variants have changed the pandemic. What will the virus do next?

Edward Holmes does not like making predictions, but last year he hazarded a few. Again and again, people had asked Holmes, an expert on viral evolution at the University of Sydney, how he expected SARS-CoV-2 to change. In May 2020, 5 months into the pandemic, he started to include a slide with his best guesses in his talks.