Andrew Read

Director, Huck Institutes of the Life Sciences; Evan Pugh Professor of Biology and Entomology; Eberly Professor of Biotechnology

Andrew Read

Research Summary

The ecology and evolutionary genetics of infectious disease.

Huck Affiliations

Links

Publication Tags

Malaria Drug Resistance Temperature Parasites Culicidae Therapeutics Pharmaceutical Preparations Vaccines Infection Anti Bacterial Agents Pathogens Daptomycin Drug Therapy Drugs Clinical Trials Chemotherapy Feeding Behavior Bacteria Dose Population Dynamics Neoplasms Anopheles Enterococcus Faecium Immunity Population

Most Recent Papers

Daptomycin treatment impacts resistance in off-target populations of vancomycin-resistant Enterococcus faecium

Clare L. Kinnear, Elsa Hansen, Valerie J. Morley, Kevin C. Tracy, Meghan Forstchen, Andrew F. Read, Robert J. Woods, 2020, PLoS Biology

An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen

Valerie J. Morley, Clare L. Kinnear, Derek G. Sim, Samantha N. Olson, Lindsey M. Jackson, Elsa Hansen, Grace A. Usher, Scott A. Showalter, Manjunath P. Pai, Robert J. Woods, Andrew F. Read, 2020, eLife on p. 1-17

Modifying adaptive therapy to enhance competitive suppression

Elsa Hansen, Andrew F. Read, 2020, Cancers on p. 1-13

Monitor for COVID-19 vaccine resistance evolution during clinical trials

David A. Kennedy, Andrew F. Read, David A. Kennedy, 2020, PLoS Biology

Cancer therapy: Attempt cure or manage drug resistance?

Elsa Hansen, Andrew F. Read, 2020, Evolutionary Applications on p. 1660-1672

Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations

Elsa Hansen, Jason Karslake, Robert J. Woods, Andrew F. Read, Kevin B. Wood, 2020, PLoS Biology

Susceptibility of Cutibacterium acnes to topical minocycline foam

Joyce Sutcliffe, Robert McLaughlin, Guy Webster, Andrew F. Read, Karl Drlica, Russell Elliott, Iain Stuart, 2020, Anaerobe

Evolutionary consequences of feedbacks between within-host competition and disease control

Megan A. Greischar, Helen K. Alexander, Farrah Bashey, Ana I. Bento, Amrita Bhattacharya, Mary Bushman, Lauren M. Childs, David R. Daversa, Troy Day, Christina L. Faust, Molly E. Gallagher, Sylvain Gandon, Caroline K. Glidden, Fletcher W. Halliday, Kathryn A. Hanley, Tsukushi Kamiya, Andrew F. Read, Philipp Schwabl, Amy R. Sweeny, Ann T. Tate, Robin N. Thompson, Nina Wale, Helen J. Wearing, Pamela J. Yeh, Nicole Mideo, 2020, Evolution, Medicine and Public Health on p. 30-34

Factors associated with antibiotic prescribing for acute bronchitis at a university health center

Valerie J. Morley, Emily P.C. Firgens, Rachel R. Vanderbilt, Yanmengqian Zhou, Michelle Zook, Andrew F. Read, Erina L. MacGeorge, 2020, BMC Infectious Diseases

Effect of drug dose and timing of treatment on the emergence of drug resistance in vivo in a malaria model

Mónica M. Acosta, Joshua T. Bram, Derek Sim, Andrew F. Read, 2020, Evolution, Medicine and Public Health on p. 196-210

Most-Cited Papers

The evolution of drug resistance and the curious orthodoxy of aggressive chemotherapy

Andrew F. Read, Troy Day, Silvie Huijben, 2011, Proceedings of the National Academy of Sciences of the United States of America on p. 10871-10877

Imperfect vaccination can enhance the transmission of highly virulent pathogens

Andrew F. Read, Susan J. Baigent, Claire Powers, Lydia B. Kgosana, Luke Blackwell, Lorraine P. Smith, David A. Kennedy, Stephen W. Walkden-Brown, Venugopal K. Nair, 2015, PLoS Biology on p. e1002198

The effect of temperature on Anopheles mosquito population dynamics and the potential for malaria transmission

Lindsay M. Beck-Johnson, William A. Nelson, Krijn P. Paaijmans, Andrew F. Read, Matthew B. Thomas, Ottar N. Bjørnstad, 2013, PLoS One

Malaria in India

Aparup Das, Anupkumar R. Anvikar, Lauren J. Cator, Ramesh C. Dhiman, Alex Eapen, Neelima Mishra, Bhupinder N. Nagpal, Nutan Nanda, Kamaraju Raghavendra, Andrew Fraser Read, Surya K. Sharma, Om P. Singh, Vineeta Singh, Photini Sinnis, Harish C. Srivastava, Steven A. Sullivan, Patrick L. Sutton, Matthew Brian Thomas, Jane M. Carlton, Neena Valecha, 2012, Acta Tropica on p. 267-273

Complex effects of temperature on mosquito immune function

C. C. Murdock, Krijn P. Paaijmans, Andrew S. Bells, Jonas G. King, Julián F. Hillyer, Andrew F. Read, Matthew B. Thomas, 2012, Proceedings of the Royal Society B: Biological Sciences on p. 3357-3366

Malaria-induced changes in host odors enhance mosquito attraction

Consuelo M. De Moraes, Nina M. Stanczyk, Heike S. Betz, Hannier Pulido, Derek G. Sim, Andrew F. Read, Mark C. Mescher, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 11079-11084

Rethinking vector immunology

Courtney C. Murdock, Krijn P. Paaijmans, Diana Cox-Foster, Andrew F. Read, Matthew B. Thomas, 2012, Nature Reviews Microbiology on p. 869-876

Does High-Dose Antimicrobial Chemotherapy Prevent the Evolution of Resistance?

Troy Day, Andrew F. Read, 2016, PLoS Computational Biology

Evolutionary history and attenuation of myxoma virus on two continents.

Peter Kerr, Elodie Ghedin, Jay DePasse, Adam Fitch, Isabella Cattadori, Peter Hudson, David Tscharke, Andrew Read, Edward Holmes, 2012, PLoS Pathogens

'Manipulation' without the parasite: Altered feeding behaviour of mosquitoes is not dependent on infection with malaria parasites

Lauren J. Cator, Justin George, Simon Blanford, Courtney C. Murdock, Thomas C. Baker, Andrew F. Read, Matthew B. Thomas, 2013, Proceedings of the Royal Society B: Biological Sciences

News Articles Featuring Andrew Read

CDC: The coronavirus could be 'just a few mutations' away from evading vaccines

The coronavirus could be just a few mutations away from evading existing COVID-19 vaccines, according to the head of the Centers for Disease Control and Prevention.

The original coronavirus strain has almost disappeared in the US. One chart shows how variants took over.

Coronavirus variants have largely replaced the original strain, rendering it essentially obsolete.

The science around the lab leak theory hasn't changed. But here's why some scientists have.

Five virologists said few conclusions can be drawn based on the available scientific evidence, but they noted that the context and circumstances of the debate have changed.

So Far, Vaccines Remain Effective Against Variants

So far, COVID-19 vaccines have been effective against variants of the coronavirus. Scientists are monitoring the situation carefully, with updated or new vaccines a possibility in the future, if need be. Social media claims blaming vaccination for an impending variant “disaster” are hypothetical predictions that ignore life-saving benefits of the vaccines.

Are the vaccines effective against mutant Covid variants?

India is undergoing a massive vaccination effort in the midst of a devastating rise in reported daily cases and deaths. While the main cause of the rise in cases is yet to be determined, epidemiological and virological data point to the rise of new variants of concern being a major contributing factor.

One-Fifth Of Allegheny County Residents Have Been Vaccinated

More than 20% of Allegheny County residents have received at least one shot of the COVID-19 vaccine, according to data from the Pennsylvania Department of Health and the VA Pittsburgh Healthcare System.

The vaccines are working. That's why we shouldn't panic about variants.

Experts stress that the Covid-19 vaccines are performing well — but that only heightens the need to lower stubbornly high case rates.

Putting wastewater to use, Penn State researchers track COVID-19 trends

A team of Penn State researchers is using wastewater testing to track the rise and fall of the COVID-19 virus in the State College area. WPSU’s Anne Danahy spoke with Andrew Read, director of the Huck Institutes of the Life Sciences, about the project.

One year since pandemic hit New York, new strain emerges in upper Manhattan

A new strain of the coronavirus, known as B.1.526, is proliferating vigorously across New York City, after having originated in February in a part of upper Manhattan known as Washington Heights.

Should the US start prioritizing first vaccine doses to beat the variants?

The answer is not straightforward and the Biden administration is still opposed—but some experts think changing the vaccination strategy will save lives.