Andrew Read

Director, Huck Institutes of the Life Sciences; Evan Pugh Professor of Biology and Entomology; Eberly Professor of Biotechnology

Andrew Read

Research Summary

The ecology and evolutionary genetics of infectious disease.

Huck Affiliations

Links

Publication Tags

Temperature Anti Bacterial Agents Therapeutics Resistance Drug Resistance Vaccines Culicidae Daptomycin Malaria Pathogens Parasites Pharmaceutical Preparations Antimicrobial Agent Resistance Management Clinical Trials Population Dynamics Bacteria Chemotherapy Microbial Drug Resistance Drug Therapy Antibiotic Resistance Neoplasms Antibiotics Enterococcus Faecium Public Health

Most Recent Papers

The economics of managing evolution

Troy Day, David A. Kennedy, Andrew F. Read, David McAdams, 2021, PLoS Biology

Daptomycin treatment impacts resistance in off-target populations of vancomycin-resistant Enterococcus faecium

Clare L. Kinnear, Elsa Hansen, Valerie J. Morley, Kevin C. Tracy, Meghan Forstchen, Andrew F. Read, Robert J. Woods, 2020, PLoS Biology

Modifying adaptive therapy to enhance competitive suppression

Elsa Hansen, Andrew F. Read, 2020, Cancers on p. 1-13

An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen

Valerie J. Morley, Clare L. Kinnear, Derek G. Sim, Samantha N. Olson, Lindsey M. Jackson, Elsa Hansen, Grace A. Usher, Scott A. Showalter, Manjunath P. Pai, Robert J. Woods, Andrew F. Read, 2020, eLife on p. 1-17

Monitor for COVID-19 vaccine resistance evolution during clinical trials

David A. Kennedy, Andrew F. Read, David A. Kennedy, 2020, PLoS Biology

Cancer therapy: Attempt cure or manage drug resistance?

Elsa Hansen, Andrew F. Read, 2020, Evolutionary Applications on p. 1660-1672

Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations

Elsa Hansen, Jason Karslake, Robert J. Woods, Andrew F. Read, Kevin B. Wood, 2020, PLoS Biology

Susceptibility of Cutibacterium acnes to topical minocycline foam

Joyce Sutcliffe, Robert McLaughlin, Guy Webster, Andrew F. Read, Karl Drlica, Russell Elliott, Iain Stuart, 2020, Anaerobe

Evolutionary consequences of feedbacks between within-host competition and disease control

Megan A. Greischar, Helen K. Alexander, Farrah Bashey, Ana I. Bento, Amrita Bhattacharya, Mary Bushman, Lauren M. Childs, David R. Daversa, Troy Day, Christina L. Faust, Molly E. Gallagher, Sylvain Gandon, Caroline K. Glidden, Fletcher W. Halliday, Kathryn A. Hanley, Tsukushi Kamiya, Andrew F. Read, Philipp Schwabl, Amy R. Sweeny, Ann T. Tate, Robin N. Thompson, Nina Wale, Helen J. Wearing, Pamela J. Yeh, Nicole Mideo, 2020, Evolution, Medicine and Public Health on p. 30-34

Factors associated with antibiotic prescribing for acute bronchitis at a university health center

Valerie J. Morley, Emily P.C. Firgens, Rachel R. Vanderbilt, Yanmengqian Zhou, Michelle Zook, Andrew F. Read, Erina L. MacGeorge, 2020, BMC Infectious Diseases

Most-Cited Papers

Imperfect vaccination can enhance the transmission of highly virulent pathogens

Andrew F. Read, Susan J. Baigent, Claire Powers, Lydia B. Kgosana, Luke Blackwell, Lorraine P. Smith, David A. Kennedy, Stephen W. Walkden-Brown, Venugopal K. Nair, 2015, PLoS Biology on p. e1002198

The effect of temperature on Anopheles mosquito population dynamics and the potential for malaria transmission

Lindsay M. Beck-Johnson, William A. Nelson, Krijn P. Paaijmans, Andrew F. Read, Matthew B. Thomas, Ottar N. Bjørnstad, 2013, PLoS One

Antibiotic resistance management

Andrew F. Read, Robert J. Woods, 2014, Evolution, Medicine and Public Health on p. 147

Malaria in India

Aparup Das, Anupkumar R. Anvikar, Lauren J. Cator, Ramesh C. Dhiman, Alex Eapen, Neelima Mishra, Bhupinder N. Nagpal, Nutan Nanda, Kamaraju Raghavendra, Andrew F. Read, Surya K. Sharma, Om P. Singh, Vineeta Singh, Photini Sinnis, Harish C. Srivastava, Steven A. Sullivan, Patrick L. Sutton, Matthew B. Thomas, Jane M. Carlton, Neena Valecha, 2012, Acta Tropica on p. 267-273

Malaria-induced changes in host odors enhance mosquito attraction

Consuelo M. De Moraes, Nina M. Stanczyk, Heike S. Betz, Hannier Pulido, Derek G. Sim, Andrew F. Read, Mark C. Mescher, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 11079-11084

Complex effects of temperature on mosquito immune function

C. C. Murdock, Krijn P. Paaijmans, Andrew S. Bells, Jonas G. King, Julián F. Hillyer, Andrew F. Read, Matthew B. Thomas, 2012, Proceedings of the Royal Society B: Biological Sciences on p. 3357-3366

Rethinking vector immunology: The role of environmental temperature in shaping resistance

Courtney C. Murdock, Krijn P. Paaijmans, Diana Cox-Foster, Andrew F. Read, Matthew B. Thomas, 2012, Nature Reviews Microbiology on p. 869-876

Does High-Dose Antimicrobial Chemotherapy Prevent the Evolution of Resistance?

Troy Day, Andrew F. Read, 2016, PLoS Computational Biology

Antibiotic resistance: a primer and call to action

Rachel A. Smith, Nkuchia M. M’ikanatha, Andrew F. Read, 2015, Health Communication on p. 309-314

Evolutionary history and attenuation of myxoma virus on two continents.

P Kerr, E Ghedin, J DePasse, A Fitch, Isabella Cattadori, P Hudson, D Tscharke, A Read, E Holmes, 2012, PLoS Pathogens on p. e1002950

News Articles Featuring Andrew Read

Jun 20, 2022

Think All Viruses Get Milder With Time? Not This Rabbit-Killer.

The myxoma virus, fatal to millions of Australian rabbits, is a textbook example of the unexpected twists in the evolution of viruses and their hosts.

Full Article

Jun 03, 2022

Two distinct monkeypox variants found in U.S., adding to outbreak’s mystery

At least two genetically distinct monkeypox variants are circulating in the U.S., according to new sequencing data from the Centers for Disease Control and Prevention.

Full Article

Apr 10, 2022

Covid-19 update with Dr Andrew Read

Will Covid-19 become an endemic, more agreeably mild virus that we just have to be wary of every winter, like the flu, or - as exemplified by the new XE variant - is this the coronavirus warming up for the main event? New Zealander Dr Andrew Read is at Pennsylvania State University. He's the director of its Institutes of Life Sciences and he specialises in the ways infectious diseases work, with expertise as well in how well vaccines cope with them. And he's working at the forefront of international research on Covid. Professor Read is back with us to cover off the latest Covid-19 developments.

Full Article

Apr 07, 2022

Preventing, controlling spread of animal diseases focus of forum at Penn State

Exploring the emergence, spread and control of animal infectious diseases was the focus of the inaugural Emerging Animal Infectious Disease Conference held Nov. 29-Dec.1, 2021, at Penn State. It was hosted by the College of Agricultural Sciences, the Pennsylvania Department of Agriculture, and Penn State’s Center for Security Research and Education.

Full Article

Mar 31, 2022

What Else Could Covid Inflict on Us? Ask Australian Rabbits

Rabbits were the victims of the deadliest epidemic in recent history — a germ warfare attack, really — with a virus that killed off more than 99% of the 100 million rabbits inhabiting Australia in 1950. However, the virus didn’t “win” — both the virus and the rabbits are still around today and continue to influence each other’s evolution.

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Feb 22, 2022

Penn State establishes the Geroscience and Dementia Prevention Consortium

There is growing evidence that cognitive decline and dementia can be slowed. According to a recent report commissioned by the Lancet, an estimated 40% of dementia cases could be prevented or delayed by targeting modifiable behavioral, physical health, and psychosocial risk factors. There are also new drug therapies being created, behavioral interventions, and other areas that have shown promise in research.

Full Article

Feb 03, 2022

More people got reinfected during the Omicron wave in UK than before it emerged, data shows. It means people who've had COVID-19 could get sick again.

People are more likely to get reinfected with Omicron than previous variants, UK data suggests.

Full Article

Jan 28, 2022

Take Note: Infectious disease expert Andrew Read on why omicron doesn't mean COVID-19 is evolving to be less severe

Researchers are studying the omicron variant: how transmissible it is, how sick it could make those infected and what this variant tells us, if anything, about how COVID-19 is evolving.

Full Article

Jan 11, 2022

Covid may become stealthier like HIV in 'silent' infection phase, experts warn

Experts have warned the next dominant Covid variant could become more manageable than Omicron, but it is also possible it could go the other way and mirror the spread of HIV or tuberculosis

Full Article

Dec 14, 2021

Is Omicron as infectious as it gets? Scientists lay out their best and worst scenarios for the virus' future.

For nearly six months, Delta seemed capable of vanquishing all other coronavirus variants — so much so that scientists wondered whether the virus had reached the apex of its ability to infect humans.

Full Article