Timothy Meredith

Assistant Professor of Biochemistry and Molecular Biology

Timothy Meredith

Research Summary

Understanding how bacterial cell surface complex lipids are synthesized, to characterize structural modifications in response to varying growth environments, and to uncover how these changes are regulated.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Staphylococcus Aureus Genes Lipopolysaccharides Anti Bacterial Agents Membranes Teichoic Acids Lactams Lipoproteins Lipoteichoic Acid Proteins Recombinant Proteins Methicillin Resistant Staphylococcus Aureus Bacteria Beta Lactams Acylation Escherichia Coli Toll Like Receptor 2 Alkaline Phosphatase Pharmaceutical Preparations Endotoxins Moenomycin Escherichia Coli Endotoxin Gram Negative Bacteria Protein Growth

Most Recent Papers

Rapid Inhibitor Discovery by Exploiting Synthetic Lethality

Jacob D. Muscato, Heidi G. Morris, Aaron Mychack, Mithila Rajagopal, Vadim Baidin, Anthony R. Hesser, Wonsik Lee, Kemal İnecik, Laura J. Wilson, Christina M. Kraml, Timothy C. Meredith, Suzanne Walker, 2022, Journal of the American Chemical Society on p. 3696-3705

Spatial regulation of protein A in Staphylococcus aureus

Ran Zhang, Mac A. Shebes, Kelvin Kho, Salvatore J. Scaffidi, Timothy C. Meredith, Wenqi Yu, 2021, Molecular Microbiology on p. 589-605

Bacterial lyso-form lipoproteins are synthesized via an intramolecular acyl chain migration

Krista M. Armbruster, Gloria Komazin, Timothy C. Meredith, 2020, Journal of Biological Chemistry on p. 10195-10211

Lipoprotein n-acylation in staphylococcus aureus is catalyzed by a two-component acyl transferase system

John H. Gardiner, Gloria Komazin, Miki Matsuo, Kaitlin Cole, Friedrich Götz, Timothy C. Meredith, 2020, mBio on p. 1-18

Copper-Induced Expression of a Transmissible Lipoprotein Intramolecular Transacylase Alters Lipoprotein Acylation and the Toll-Like Receptor 2 Response to Listeria monocytogenes

Krista M. Armbruster, Gloria Komazin, Timothy C. Meredith, 2019, Journal of Bacteriology

Streptococcus gordonii Type I lipoteichoic acid contributes to surface protein biogenesis

Bruno P. Lima, Kelvin Kho, Brittany L. Nairn, Gunnel Svensäter, Ruoqiong Chen, Amanda Steffes, Gerrit W. Vreeman, Timothy C. Meredith, Mark C. Herzberg, 2019, mSphere

Multi-strain Tn-Seq reveals common daptomycin resistance determinants in Staphylococcus aureus

Kathryn A. Coe, Wonsik Lee, Madeleine C. Stone, Gloria Komazin-Meredith, Timothy C. Meredith, Yonatan H. Grad, Suzanne Walker, 2019, PLoS Pathogens

Substrate structure-activity relationship reveals a limited lipopolysaccharide chemotype range for intestinal alkaline phosphatase

Gloria Komazin, Michael Maybin, Ronald W. Woodard, Thomas Scior, Dominik Schwudke, Ursula Schombel, Nicolas Gisch, Uwe Mamat, Timothy C. Meredith, 2019, Journal of Biological Chemistry on p. 19405-19423

Cell-based screen for discovering lipopolysaccharide biogenesis inhibitors

Ge Zhang, Vadim Baidin, Karanbir S. Pahil, Eileen Moison, David Tomasek, Nitya S. Ramadoss, Arnab K. Chatterjee, Case W. McNamara, Travis S. Young, Peter G. Schultz, Timothy C. Meredith, Daniel Kahne, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. 6834-6839

Antibiotic Combinations That Enable One-Step, Targeted Mutagenesis of Chromosomal Genes

Wonsik Lee, Truc Do, Ge Zhang, Daniel Kahne, Timothy C. Meredith, Suzanne Walker, 2018, ACS Infectious Diseases on p. 1007-1018

Most-Cited Papers

Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics.

Christopher M. Tan, Alex G. Therien, Jun Lu, Sang H. Lee, Alexandre Caron, Charles J. Gill, Christian Lebeau-Jacob, Liliana Benton-Perdomo, João M. Monteiro, Pedro M. Pereira, Nathaniel L. Elsen, Jin Wu, Kathleen Deschamps, Mihai Petcu, Simon Wong, Etienne Daigneault, Susanne Kramer, Lianzhu Liang, Eugene Maxwell, David Claveau, John Vaillancourt, Kathryn Skorey, John Tam, Hao Wang, Timothy C. Meredith, Susan Sillaots, Lisa Wang-Jarantow, Yeeman Ramtohul, Eric Langlois, France Landry, John C. Reid, Gopal Parthasarathy, Sujata Sharma, Anastasia Baryshnikova, Kevin J. Lumb, Mariana G. Pinho, Stephen M. Soisson, Terry Roemer, 2012, Science Translational Medicine on p. 126ra35

Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids

Stephanie Brown, Guoqing Xia, Lyly G. Luhachack, Jennifer Campbell, Timothy C. Meredith, Calvin Chen, Volker Winstel, Cordula Gekeler, Javier E. Irazoqui, Andreas Peschel, Suzanne Walker, 2012, Proceedings of the National Academy of Sciences of the United States of America on p. 18909-18914

On the essentiality of lipopolysaccharide to Gram-negative bacteria

Ge Zhang, Timothy C. Meredith, Daniel Kahne, 2013, Current Opinion in Microbiology on p. 779-785

Detoxifying Escherichia coli for endotoxin-free production of recombinant proteins

Uwe Mamat, Kathleen Wilke, David Bramhill, Andra Beate Schromm, Buko Lindner, Thomas Andreas Kohl, José Luis Corchero, Antonio Villaverde, Lana Schaffer, Steven Robert Head, Chad Souvignier, Timothy Charles Meredith, Ronald Wesley Woodard, 2015, Microbial Cell Factories

Discovery of wall teichoic acid inhibitors as potential anti-MRSA β-lactam combination agents

Hao Wang, Charles J. Gill, Sang H. Lee, Paul Mann, Paul Zuck, Timothy C. Meredith, Nicholas Murgolo, Xinwei She, Susan Kales, Lianzhu Liang, Jenny Liu, Jin Wu, John Santa Maria, Jing Su, Jianping Pan, Judy Hailey, Debra McGuinness, Christopher M. Tan, Amy Flattery, Suzanne Walker, Todd Black, Terry Roemer, 2013, Cell Chemical Biology on p. 272-284

Fatty acid biosynthesis in Pseudomonas aeruginosa is initiated by the faby class of β-ketoacyl acyl carrier protein synthases

Yanqiu Yuan, Meena Sachdeva, Jennifer A. Leeds, Timothy C. Meredith, 2012, Journal of Bacteriology on p. 5171-5184

A new platform for ultra-high density Staphylococcus aureus transposon libraries

Marina Santiago, Leigh M. Matano, Samir H. Moussa, Michael S. Gilmore, Suzanne Walker, Timothy C. Meredith, 2015, BMC Genomics

A synthetic lethal approach for compound and target identification in Staphylococcus aureus

Lincoln Pasquina, John P. Santa Maria, B. McKay Wood, Samir H. Moussa, Leigh M. Matano, Marina Santiago, Sara E.S. Martin, Wonsik Lee, Timothy C. Meredith, Suzanne Walker, 2016, Nature Chemical Biology on p. 40-45

Cell-based screen for discovering lipopolysaccharide biogenesis inhibitors

Ge Zhang, Vadim Baidin, Karanbir S. Pahil, Eileen Moison, David Tomasek, Nitya S. Ramadoss, Arnab K. Chatterjee, Case W. McNamara, Travis S. Young, Peter G. Schultz, Timothy C. Meredith, Daniel Kahne, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. 6834-6839

Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin.

Roman Makitrynskyy, Bohdan Ostash, Olga Tsypik, Yuriy Rebets, Emma Doud, Timothy Meredith, Andriy Luzhetskyy, Andreas Bechthold, Suzanne Walker, Victor Fedorenko, 2013, Open Biology on p. 130121