Timothy Meredith

Associate Professor of Biochemistry and Molecular Biology

206 Frear South
University Park, PA
txm50@psu.edu
814-867-5909

Bio & Links
Publications

Research Summary

Understanding how bacterial cell surface complex lipids are synthesized, to characterize structural modifications in response to varying growth environments, and to uncover how these changes are regulated.

Huck Graduate Students

Huck Affiliations

Molecular, Cellular, and Integrative Biosciences

Publication Tags

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Staphylococcus Aureus Lipoproteins Genes Anti Bacterial Agents Lipoteichoic Acid Lipopolysaccharides Membranes Listeria Monocytogenes Copper Recombinant Proteins Proteins Libraries Acylation Toll Like Receptor 2 Escherichia Coli Alkaline Phosphatase Bacteria Escherichia Coli Endotoxin Endotoxins R Factors Membrane Proteins Penicillins Lethal Lipopolysaccharide Growth

Most Recent Publications

Inhibition of biofilm formation by a lipopolysaccharide-associated glycosyltransferase in the bacterial symbiont Vibrio fischeri

Edward Provencher, Molly Ehrig, Andrew Cecere, Shyan Cousins, Michael Maybin, Timothy Meredith, Tim Miyashiro, 2023, Frontiers in Bacteriology

The Extracellular Electron Transport Pathway Reduces Copper for Sensing by the CopRS Two-Component System under Anaerobic Conditions in Listeria monocytogenes

A Rizk, G Komazin, Gloria Meredith, M Maybin, N Hoque, Hoque Nushrat, Emily Weinert, Timothy Meredith, 2023, Journal of Bacteriology on p. e00391-22

A Copper-Responsive Two-Component System Governs Lipoprotein Remodeling in Listeria monocytogenes

Gloria Meredith, G Komazin, A Rizk, K Armbruster, V Bonnell, Manuel Llinas, Manuel Llinás, Timothy Meredith, 2023, Journal of Bacteriology on p. e0039022

Rapid Inhibitor Discovery by Exploiting Synthetic Lethality

Jacob D. Muscato, Heidi G. Morris, Aaron Mychack, Mithila Rajagopal, Vadim Baidin, Anthony R. Hesser, Wonsik Lee, Kemal İnecik, Laura J. Wilson, Christina M. Kraml, Timothy C. Meredith, Suzanne Walker, 2022, Journal of the American Chemical Society on p. 3696-3705

Spatial regulation of protein A in Staphylococcus aureus

Ran Zhang, Mac A. Shebes, Kelvin Kho, Salvatore J. Scaffidi, Timothy C. Meredith, Wenqi Yu, 2021, Molecular Microbiology on p. 589-605

Bacterial lyso-form lipoproteins are synthesized via an intramolecular acyl chain migration

Krista M. Armbruster, Gloria Komazin, Timothy C. Meredith, 2020, Journal of Biological Chemistry on p. 10195-10211

Lipoprotein n-acylation in staphylococcus aureus is catalyzed by a two-component acyl transferase system

John H. Gardiner, Gloria Komazin, Miki Matsuo, Kaitlin Cole, Friedrich Götz, Timothy C. Meredith, 2020, mBio on p. 1-18

Streptococcus gordonii Type I lipoteichoic acid contributes to surface protein biogenesis

Bruno P. Lima, Kelvin Kho, Brittany L. Nairn, Gunnel Svensäter, Ruoqiong Chen, Amanda Steffes, Gerrit W. Vreeman, Timothy C. Meredith, Mark C. Herzberg, 2019, mSphere

Copper-Induced Expression of a Transmissible Lipoprotein Intramolecular Transacylase Alters Lipoprotein Acylation and the Toll-Like Receptor 2 Response to Listeria monocytogenes

Krista M. Armbruster, Gloria Komazin, Timothy C. Meredith, 2019, Journal of Bacteriology

Substrate structure-activity relationship reveals a limited lipopolysaccharide chemotype range for intestinal alkaline phosphatase

Gloria Komazin, Michael Maybin, Ronald W. Woodard, Thomas Scior, Dominik Schwudke, Ursula Schombel, Nicolas Gisch, Uwe Mamat, Timothy C. Meredith, 2019, Journal of Biological Chemistry on p. 19405-19423

Most-Cited Papers

Detoxifying Escherichia coli for endotoxin-free production of recombinant proteins

Uwe Mamat, Kathleen Wilke, David Bramhill, Andra Beate Schromm, Buko Lindner, Thomas Andreas Kohl, José Luis Corchero, Antonio Villaverde, Lana Schaffer, Steven Robert Head, Chad Souvignier, Timothy Charles Meredith, Ronald Wesley Woodard, 2015, Microbial Cell Factories

Cell-based screen for discovering lipopolysaccharide biogenesis inhibitors

Ge Zhang, Vadim Baidin, Karanbir S. Pahil, Eileen Moison, David Tomasek, Nitya S. Ramadoss, Arnab K. Chatterjee, Case W. McNamara, Travis S. Young, Peter G. Schultz, Timothy C. Meredith, Daniel Kahne, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. 6834-6839

A new platform for ultra-high density Staphylococcus aureus transposon libraries

Marina Santiago, Leigh M. Matano, Samir H. Moussa, Michael S. Gilmore, Suzanne Walker, Timothy C. Meredith, 2015, BMC Genomics

A synthetic lethal approach for compound and target identification in Staphylococcus aureus

Lincoln Pasquina, John P. Santa Maria, B. McKay Wood, Samir H. Moussa, Leigh M. Matano, Marina Santiago, Sara E.S. Martin, Wonsik Lee, Timothy C. Meredith, Suzanne Walker, 2016, Nature Chemical Biology on p. 40-45

Multi-strain Tn-Seq reveals common daptomycin resistance determinants in Staphylococcus aureus

Kathryn A. Coe, Wonsik Lee, Madeleine C. Stone, Gloria Komazin-Meredith, Timothy C. Meredith, Yonatan H. Grad, Suzanne Walker, 2019, PLoS Pathogens

Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic article

Marina Santiago, Wonsik Lee, Antoine Abou Fayad, Kathryn A. Coe, Mithila Rajagopal, Truc Do, Fabienne Hennessen, Veerasak Srisuknimit, Rolf Müller, Timothy C. Meredith, Suzanne Walker, 2018, Nature Chemical Biology on p. 601-608

Multidrug intrinsic resistance factors in Staphylococcus aureus identified by profiling fitness within high-diversity transposon libraries

Mithila Rajagopal, Melissa J. Martin, Marina Santiago, Wonsik Lee, Veronica N. Kos, Tim Meredith, Michael S. Gilmore, Suzanne Walker, 2016, mBio