Susan Hafenstein

Susan Hafenstein

Huck Chair of Structural Biology; Associate Professor of Biochemistry and Molecular Biology

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Bio

Using a structural approach to learn more about viral infectivity, tropism, evolution and pathogenicity. Developing approaches to visualize critical events that cause a break from the regular symmetry of the virus, including packaging of the genome, receptor usage, antibody interactions and uncoating of the viral genome during the final stages of infection.

Education

  • Ph.D., University of Arizona, Tucson, AZ, 2003
  • B.S., Louisiana State University, Baton Rouge, LA, 1992

Huck Graduate Students

Publication Tags

Capsid Genome Parvovirus Infection Mutation Viruses Protoparvovirus Virion Antibodies Cryoelectron Microscopy Receptors Capsid Proteins Human Papillomavirus 16 Canine Parvovirus Cells Transferrin Receptors Dogs Binding Sites Host Specificity Divalent Cations Host Range Minute Virus Of Mice Mastadenovirus Enterovirus Heparin

Most Recent Papers

Transferrin receptor binds virus capsid with dynamic motion

Hyunwook Lee, Heather M. Callaway, Javier O. Cifuente, Carol M. Bator, Colin R. Parrish, Susan L. Hafenstein, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 20462-20471

Parvovirus B19 uncoating occurs in the cytoplasm without capsid disassembly and it is facilitated by depletion of capsid-associated divalent cations

Oliver Caliaro, Andrea Marti, Nico Ruprecht, Remo Leisi, Suriyasri Subramanian, Susan Hafenstein, Carlos Ros, 2019, Viruses on p. 430

Examination and reconstruction of three ancient endogenous parvovirus capsid protein gene remnants found in rodent genomes

Heather M. Callaway, Suriyasri Subramanian, Christian A. Urbina, Karen N. Barnard, Robert A. Dick, Carol M. Bator, Susan L. Hafenstein, Robert J. Gifford, Colin R. Parrish, 2019, Journal of virology

Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus - A 71 capsid

Liang Sun, Hyunwook Lee, Hendrik Jan Thibaut, Kristina Lanko, Eva Rivero-Buceta, Carol Bator, Belen Martinez-Gualda, Kai Dallmeier, Leen Delang, Pieter Leyssen, Federico Gago, Ana San-Felix, Susan Hafenstein, Carmen Mirabelli, Johan Neyts, 2019, PLoS pathogens

Complex and dynamic interactions between parvovirus capsids, transferrin receptors, and antibodies control cell infection and host range

Heather M. Callaway, Kathrin Welsch, Wendy Weichert, Andrew B. Allison, Susan L. Hafenstein, Kai Huang, Sho Iketani, Colin R. Parrish, 2018, Journal of virology

Nuclear, cytosolic, and surface-localized poly(A)-binding proteins of Plasmodium yoelii

Allen M. Minns, Kevin J. Hart, Suriyasri Subramanian, Susan Hafenstein, Scott E. Lindner, 2018, mSphere

Cryo-EM maps reveal five-fold channel structures and their modification by gatekeeper mutations in the parvovirus minute virus of mice (MVM) capsid

Suriyasri Subramanian, Lindsey J. Organtini, Alec Grossman, Phillip P. Domeier, Javier O. Cifuente, Alexander M. Makhov, James F. Conway, Anthony D'Abramo, Susan F. Cotmore, Peter Tattersall, Susan Hafenstein, 2017, Virology on p. 216-223

Cryoelectron Microscopy Maps of Human Papillomavirus 16 Reveal L2 Densities and Heparin Binding Site

Jian Guan, Stephanie M. Bywaters, Sarah A. Brendle, Robert E. Ashley, Alexander M. Makhov, James F. Conway, Neil D. Christensen, Susan Hafenstein, 2017, Structure on p. 253-263

MOPS and coxsackievirus B3 stability

Steven D. Carson, Susan Hafenstein, Hyunwook Lee, 2017, Virology on p. 183-187

Parvovirus capsid structures required for infection

Heather M. Callaway, Kurtis H. Feng, Donald W. Lee, Andrew B. Allison, Melissa Pinard, Robert McKenna, Mavis Agbandje-McKenna, Susan Hafenstein, Colin R. Parrish, 2017, Journal of virology

Recent Most-Cited Papers

Secretion of genome-free hepatitis b virus - single strand blocking model for virion morphogenesis of para-retrovirus

Xiaojun Ning, David Nguyen, Laura Mentzer, Christina Adams, Hyunwook Lee, Robert Ashley, Susan Hafenstein, Jianming Hu, 2011, PLoS pathogens

Depletion of virion-associated divalent cations induces parvovirus minute virus of mice to eject its genome in a 3′ -to-5′ direction from an otherwise intact viral particle

Susan F. Cotmore, Susan Hafenstein, Peter Tattersall, 2010, Journal of virology on p. 1945-1956

Structural comparison of four different antibodies interacting with human papillomavirus 16 and mechanisms of neutralization

Jian Guan, Stephanie M. Bywaters, Sarah A. Brendle, Hyunwook Lee, Robert E. Ashley, Alexander M. Makhov, James F. Conway, Neil Christensen, Susan Hafenstein, 2015, Virology on p. 253-263

Cryoelectron Microscopy Maps of Human Papillomavirus 16 Reveal L2 Densities and Heparin Binding Site

Jian Guan, Stephanie M. Bywaters, Sarah A. Brendle, Robert E. Ashley, Alexander M. Makhov, James F. Conway, Neil D. Christensen, Susan Hafenstein, 2017, Structure on p. 253-263

Assembly and characterization of foot-and-mouth disease virus empty capsid particles expressed within mammalian cells

Maria Gullberg, Bartosz Muszynski, Lindsey J. Organtini, Robert E. Ashley, Susan L. Hafenstein, Graham J. Belsham, Charlotta Polacek, 2013, Journal of General Virology on p. 1769-1779

Single mutations in the VP2 300 loop region of the three-fold spike of the carnivore parvovirus capsid can determine host range

Andrew B. Allison, Lindsey J. Organtini, Sheng Zhang, Susan L. Hafenstein, Edward C. Holmes, Colin R. Parrish, 2016, Journal of virology on p. 753-767

Evolution and cryo-electron microscopy capsid structure of a north american bat adenovirus and its relationship to other mastadenoviruses

Nicole Hackenbrack, Matthew B. Rogers, Robert E. Ashley, M. Kevin Keel, Steven V. Kubiski, John A. Bryan, Elodie Ghedin, Edward C. Holmes, Susan L. Hafenstein, Andrew B. Allison, 2017, Journal of virology

Near-atomic resolution structure of a highly neutralizing fab bound to canine parvovirus

Lindsey J. Organtini, Hyunwook Lee, Sho Iketani, Kai Huang, Robert E. Ashley, Alexander M. Makhov, James F. Conway, Colin R. Parrish, Susan Hafenstein, 2016, Journal of virology on p. 9733-9742

Honey bee deformed wing virus structures reveal that conformational changes accompany genome release

Lindsey J. Organtini, Kristin L. Shingler, Robert E. Ashley, Elizabeth A. Capaldi, Kulsoom Durrani, Kelly A. Dryden, Alexander M. Makhov, James F. Conway, Marie C. Pizzorno, Susan Hafenstein, 2017, Journal of virology

Parvovirus capsid structures required for infection

Heather M. Callaway, Kurtis H. Feng, Donald W. Lee, Andrew B. Allison, Melissa Pinard, Robert McKenna, Mavis Agbandje-McKenna, Susan Hafenstein, Colin R. Parrish, 2017, Journal of virology