Greg Shearer

Associate Professor of Nutritional Sciences

Greg Shearer

Research Summary

We seek to understand disease-related functional changes in the context of global changes in lipid mediators (bioactive metabolites of dietary fatty acids) and use them to identify markers of disease and better ways to prevent or manage disease

Huck Graduate Students

Huck Affiliations

Publication Tags

Fatty Acids Omega 3 Fatty Acids Inflammation Cardiovascular Diseases Oxylipins Fatty Acid Nonesterified Fatty Acids Hdl Lipoproteins Liver Longitudinal Studies Microbiota Atherosclerosis Eicosapentaenoic Acid Oleic Acid Apolipoprotein A I Unsaturated Fatty Acids Heart Failure Therapeutics Colitis Aspirin Fermentation Omega 3 Fatty Acid Oleoylethanolamide Dietary Fiber Esters

Most Recent Papers

Free fatty acid receptor 4 responds to endogenous fatty acids to protect the heart from pressure overload

Katherine A. Murphy, Brian A. Harsch, Chastity L. Healy, Sonal S. Joshi, Shue Huang, Rachel E. Walker, Brandon M. Wagner, Katherine M. Ernste, Wei Huang, Robert C. Block, Casey D. Wright, Nathan Tintle, Brian C. Jensen, Quinn S. Wells, Gregory C. Shearer, Timothy D. O'Connell, 2022, Cardiovascular Research on p. 1061-1073

Soybean oil lowers circulating cholesterol levels and coronary heart disease risk, and has no effect on markers of inflammation and oxidation

Mark Messina, Gregory Shearer, Kristina Petersen, 2021, Nutrition

Aspirin and omega-3 fatty acid status interact in the prevention of cardiovascular diseases in Framingham Heart Study

Robert C. Block, Gregory C. Shearer, Ashley Holub, Xin M. Tu, Shaker Mousa, J. Thomas Brenna, William S. Harris, Nathan Tintle, 2021, Prostaglandins Leukotrienes and Essential Fatty Acids

Effects of inflammation and soluble epoxide hydrolase inhibition on oxylipin composition of very low-density lipoproteins in isolated perfused rat livers

Rachel E. Walker, Olga V. Savinova, Theresa L. Pedersen, John W. Newman, Gregory C. Shearer, 2021, Physiological Reports

Trafficking of nonesterified fatty acids in insulin resistance and relationship to dysglycemia

Rachel E. Walker, Jennifer L. Ford, Raymond C. Boston, Olga V. Savinova, William S. Harris, Michael H. Green, Gregory C. Shearer, 2020, American Journal of Physiology on p. E392-E404

Mechanistic insights into cardiovascular protection for omega-3 fatty acids and their bioactive lipid metabolites

Timothy D. O'Connell, Richard Preston Mason, Matthew J. Budoff, Ann Marie Navar, Gregory C. Shearer, 2020, European Heart Journal, Supplement on p. J3-J20

Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop

Annabelle Rodriguez, Bernardo L. Trigatti, Chieko Mineo, Darcy Knaack, John T. Wilkins, Daisy Sahoo, Bela F. Asztalos, Samia Mora, Marina Cuchel, Henry J. Pownall, Corina Rosales, Pascal Bernatchez, Amanda Ribeiro Martins Da Silva, Godfrey S. Getz, Jacob L. Barber, Gregory C. Shearer, Angela M. Zivkovic, Uwe J.F. Tietge, Frank M. Sacks, Margery A. Connelly, Michael N. Oda, W. Sean Davidson, Mary G. Sorci-Thomas, Tomas Vaisar, Giacomo Ruotolo, Kasey C. Vickers, Catherine Martel, 2019, Arteriosclerosis, Thrombosis, and Vascular Biology on p. 2457-2467

Predicting the effects of supplemental EPA and DHA on the omega-3 index

Rachel E. Walker, Kristina Harris Jackson, Nathan L. Tintle, Gregory C. Shearer, Aldo Bernasconi, Serge Masson, Roberto Latini, Bobak Heydari, Raymond Y. Kwong, Michael Flock, Penny M. Kris-Etherton, Anne Hedengran, Robert M. Carney, Ann Skulas-Ray, Samuel S. Gidding, Antonella Dewell, Christopher D. Gardner, S. Marlene Grenon, Barbara Sarter, John W. Newman, Theresa L. Pedersen, Mark K. Larson, William S. Harris, 2019, American Journal of Clinical Nutrition on p. 1034-1040

Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation.

Vishal Singh, Beng San Yeoh, Rachel E. Walker, Xia Xiao, Piu Saha, Rachel M. Golonka, Jingwei Cai, Alexis Charles Andre Bretin, Xi Cheng, Qing Liu, Michael D. Flythe, Benoit Chassaing, Gregory C. Shearer, Andrew D. Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2019, Gut on p. 1801-1812

Predicting Risk for Incident Heart Failure With Omega-3 Fatty Acids

Robert C. Block, Linxi Liu, David M. Herrington, Shue Huang, Michael Y. Tsai, Timothy D. O'Connell, Gregory C. Shearer, 2019, JACC: Heart Failure on p. 651-661

Most-Cited Papers

Fish oil - How does it reduce plasma triglycerides?

Gregory C. Shearer, Olga V. Savinova, William S. Harris, 2012, BBA - Specialised Section On Lipids and Related Subjects on p. 843-851

Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice

Vishal Singh, Benoit Chassaing, Limin Zhang, Beng San Yeoh, Xia Xiao, Manish Kumar, Mark T. Baker, Jingwei Cai, Rachel Walker, Kamil Borkowski, Kevin J. Harvatine, Nagendra Singh, Gregory C. Shearer, James M. Ntambi, Bina Joe, Andrew D. Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2015, Cell Metabolism on p. 983-996

Basal omega-3 fatty acid status affects fatty acid and oxylipin responses to high-dose n3-HUFA in healthy volunteers

Alison H. Keenan, Theresa L. Pedersen, Kristi Fillaus, Mark K. Larson, Gregory C. Shearer, John W. Newman, 2012, Journal of Lipid Research on p. 1662-1669

Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation.

Vishal Singh, Beng San Yeoh, Rachel E. Walker, Xia Xiao, Piu Saha, Rachel M. Golonka, Jingwei Cai, Alexis Charles Andre Bretin, Xi Cheng, Qing Liu, Michael D. Flythe, Benoit Chassaing, Gregory C. Shearer, Andrew D. Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2019, Gut on p. 1801-1812

Longitudinal study of alcohol consumption and HDL concentrations

Shue Huang, Junjuan Li, Gregory C. Shearer, Alice H. Lichtenstein, Xiaoming Zheng, Yuntao Wu, Cheng Jin, Shouling Wu, Xiang Gao, 2017, American Journal of Clinical Nutrition on p. 905-912

Oleic acid-derived oleoylethanolamide: A nutritional science perspective

Kate J. Bowen, Penny M. Kris-Etherton, Gregory C. Shearer, Sheila G. West, Lavanya Reddivari, Peter J.H. Jones, 2017, Progress in Lipid Research on p. 1-15

Omega-6 fatty acids and cardiovascular disease friend, not foe?

William S. Harris, Gregory C. Shearer, 2014, Circulation on p. 1562-1564

A genome-wide association study of saturated, mono- and polyunsaturated red blood cell fatty acids in the Framingham Heart Offspring Study

N. L. Tintle, J. V. Pottala, S. Lacey, V. Ramachandran, J. Westra, A. Rogers, J. Clark, B. Olthoff, M. Larson, W. Harris, G. C. Shearer, 2015, Prostaglandins Leukotrienes and Essential Fatty Acids on p. 65-72

HDL-apoA-I Exchange

Mark S. Borja, Lei Zhao, Bradley Hammerson, Chongren Tang, Richard Yang, Nancy Carson, Gayani Fernando, Xiaoqin Liu, Madhu S. Budamagunta, Jacques Genest, Gregory C. Shearer, Franck Duclos, Michael N. Oda, 2013, PLoS One on p. e71541

ω3-Polyunsaturated fatty acids for heart failure

Timothy D. O'Connell, Robert C. Block, Shue P. Huang, Gregory C. Shearer, 2017, Journal of Molecular and Cellular Cardiology on p. 74-92