Greg Shearer

Associate Professor of Nutritional Sciences

Greg Shearer

Research Summary

We seek to understand disease-related functional changes in the context of global changes in lipid mediators (bioactive metabolites of dietary fatty acids) and use them to identify markers of disease and better ways to prevent or manage disease

Huck Graduate Students

Huck Affiliations

Publication Tags

Fatty Acids Omega 3 Fatty Acids Oxylipins Inflammation Nonesterified Fatty Acids Unsaturated Fatty Acids Fatty Acid Liver Longitudinal Studies Cardiovascular Diseases Eicosapentaenoic Acid Oleic Acid Lipids Heart Failure Esters Microbiota Aspirin Oleoylethanolamide Oxylipin Omega 3 Fatty Acid Triglycerides Therapeutics Erythrocytes Metabolic Syndrome Docosahexaenoic Acids

Most Recent Publications

Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease

Timothy D. O’connell, Katherine A. Murphy, Naixin Zhang, Sara J. Puccini, Chastity L. Healy, Brian A. Harsch, Michael J. Zhang, Gregory C. Shearer, 2022, Physiology on p. 311-322

Katherine A. Murphy, Brian A. Harsch, Chastity L. Healy, Sonal S. Joshi, Shue Huang, Rachel E. Walker, Brandon M. Wagner, Katherine M. Ernste, Wei Huang, Robert C. Block, Casey D. Wright, Nathan Tintle, Brian C. Jensen, Quinn S. Wells, Gregory C. Shearer, Timothy D. O'Connell, 2022, Cardiovascular Research on p. 1061-1073

Robert C. Block, Gregory C. Shearer, Ashley Holub, Xin M. Tu, Shaker Mousa, J. Thomas Brenna, William S. Harris, Nathan Tintle, 2021, Prostaglandins Leukotrienes and Essential Fatty Acids

Rachel E. Walker, Olga V. Savinova, Theresa L. Pedersen, John W. Newman, Gregory C. Shearer, 2021, Physiological Reports

Rachel E. Walker, Jennifer L. Ford, Raymond C. Boston, Olga V. Savinova, William S. Harris, Michael H. Green, Gregory C. Shearer, 2020, American Journal of Physiology on p. E392-E404

Timothy D. O'Connell, Richard Preston Mason, Matthew J. Budoff, Ann Marie Navar, Gregory C. Shearer, 2020, European Heart Journal, Supplement on p. J3-J20

Annabelle Rodriguez, Bernardo L. Trigatti, Chieko Mineo, Darcy Knaack, John T. Wilkins, Daisy Sahoo, Bela F. Asztalos, Samia Mora, Marina Cuchel, Henry J. Pownall, Corina Rosales, Pascal Bernatchez, Amanda Ribeiro Martins Da Silva, Godfrey S. Getz, Jacob L. Barber, Gregory C. Shearer, Angela M. Zivkovic, Uwe J.F. Tietge, Frank M. Sacks, Margery A. Connelly, Michael N. Oda, W. Sean Davidson, Mary G. Sorci-Thomas, Tomas Vaisar, Giacomo Ruotolo, Kasey C. Vickers, Catherine Martel, 2019, Arteriosclerosis, Thrombosis, and Vascular Biology on p. 2457-2467

R Walker, Kristina Harris Jackson, Kristina Harris-Jackson, N Tintle, Gregory Shearer, A Bernasconi, S Masson, R Latini, B Heydari, R Kwong, M Flock, Penny M. Kris-Etherton, A Hedengran, R Carney, A Skulas-Ray, S Gidding, A Dewell, C Gardner, S Grenon, B Sarter, J Newman, T Pedersen, M Larson, W Harris, 2019, American Journal of Clinical Nutrition on p. 1034-1040

Robert C. Block, Linxi Liu, David M. Herrington, Shue Huang, Michael Y. Tsai, Timothy D. O'Connell, Gregory C. Shearer, 2019, JACC: Heart Failure on p. 651-661

Most-Cited Papers

Gregory C. Shearer, Olga V. Savinova, William S. Harris, 2012, BBA - Specialised Section On Lipids and Related Subjects on p. 843-851

Vishal Singh, Benoit Chassaing, Limin Zhang, Beng San Yeoh, Xia Xiao, Manish Kumar, Mark T. Baker, Jingwei Cai, Rachel Walker, Kamil Borkowski, Kevin J. Harvatine, Nagendra Singh, Gregory C. Shearer, James M. Ntambi, Bina Joe, Andrew D. Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2015, Cell Metabolism on p. 983-996

Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation

Vishal Singh, Beng San Yeoh, Rachel Walker, Xia Xiao, Piu Saha, Rachel Golonka, Jingwei Cai, Alexis Bretin, Bretin ACA, Xi Cheng, Qing Liu, Michael Flythe, Benoit Chassaing, Gregory C. Shearer, Andrew D. Patterson, Andrew Gewirtz, Matam Vijay-Kumar, 2019, Gut on p. 1801-1812

Alison H. Keenan, Theresa L. Pedersen, Kristi Fillaus, Mark K. Larson, Gregory C. Shearer, John W. Newman, 2012, Journal of Lipid Research on p. 1662-1669

Shue Huang, Junjuan Li, Gregory C. Shearer, Alice H. Lichtenstein, Xiaoming Zheng, Yuntao Wu, Cheng Jin, Shouling Wu, Xiang Gao, 2017, American Journal of Clinical Nutrition on p. 905-912

Oleic acid-derived oleoylethanolamide: A nutritional science perspective

Kate J. Bowen, Penny M. Kris-Etherton, Gregory C. Shearer, Sheila G. West, Lavanya Reddivari, Peter J.H. Jones, 2017, Progress in Lipid Research on p. 1-15

N. L. Tintle, J. V. Pottala, S. Lacey, V. Ramachandran, J. Westra, A. Rogers, J. Clark, B. Olthoff, M. Larson, W. Harris, G. C. Shearer, 2015, Prostaglandins Leukotrienes and Essential Fatty Acids on p. 65-72

Omega-6 fatty acids and cardiovascular disease friend, not foe?

William S. Harris, Gregory C. Shearer, 2014, Circulation on p. 1562-1564

An overview of the biologic effects of omega-6 oxylipins in humans

Gregory C. Shearer, Rachel E. Walker, 2018, Prostaglandins Leukotrienes and Essential Fatty Acids on p. 26-38

Timothy D. O'Connell, Robert C. Block, Shue P. Huang, Gregory C. Shearer, 2017, Journal of Molecular and Cellular Cardiology on p. 74-92