Professor and Huck Chair of Molecular Toxicology; Faculty Oversight, Metabolomics Core Facility
The Patterson lab is focused on understanding the host-metabolite-microbiome axis
Huck Graduate Students
- Metabolomics Core Facility
- Integrative and Biomedical Physiology
- Molecular, Cellular, and Integrative Biosciences
- Bioinformatics and Genomics
- Center for Molecular Toxicology and Carcinogenesis
- One Health Microbiome Center
These publication tags are generated from the output of this researcher. Click any tag below to view other Huck researchers working on the same topic.Gastrointestinal Microbiome Obesity Intestines Metabolic Aryl Hydrocarbon Receptors Ligands Glycine Liver Bile Acids And Salts Microbiota Muricholic Acid Nutrition Fermentation Tempol Hydrocarbons Acid Hydrocarbon Metformin Toxicity Therapeutics Fats Glucose Homeostasis Metabolism Pharmacological Metabolism
Most Recent Publications
Xenobiotic Receptor-Mediated Toxicity
GH Perdew, IA Murray, JM Peters,
Lulu Sun, Yi Zhang, Jie Cai, Bipin Rimal, Edson R. Rocha, James P. Coleman, Chenran Zhang, Robert G. Nichols, Yuhong Luo, Bora Kim, Yaozong Chen, Kristopher W. Krausz, Curtis C. Harris, Andrew D. Patterson, Zhipeng Zhang, Shogo Takahashi, Frank J. Gonzalez, 2023, Nature Communications
Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in Ppara Transgenic Mice
Xiaoyang Zhu, Qing Liu, Andrew D. Patterson, Arun K. Sharma, Shantu G. Amin, Samuel M. Cohen, Frank J. Gonzalez, Jeffrey M. Peters, 2023, Metabolites
Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus)
Xiaoling Chen, Andrew D. Patterson, Gary H. Perdew, Iain A. Murray, Joshua J. Kellogg, 2023, Journal of Functional Foods
Fangcong Dong, Iain A. Murray, Andrew Annalora, Denise M. Coslo, Dhimant Desai, Krishne Gowda, Jian Yang, Dingbowen Wang, Imhoi Koo, Fuhua Hao, Shantu G. Amin, Andrew D. Patterson, Craig Marcus, Gary H. Perdew, 2023, FASEB Journal on p. e23010
Dari Shalon, Rebecca Neal Culver, Jessica A. Grembi, Jacob Folz, Peter V. Treit, Handuo Shi, Florian A. Rosenberger, Les Dethlefsen, Xiandong Meng, Eitan Yaffe, Andrés Aranda-Díaz, Philipp E. Geyer, Johannes B. Mueller-Reif, Sean Spencer, Andrew D. Patterson, George Triadafilopoulos, Susan P. Holmes, Matthias Mann, Oliver Fiehn, David A. Relman, Kerwyn Casey Huang, 2023, Nature on p. 581-591
The Ah Receptor from Toxicity to Therapeutics: Report from the 5th AHR Meeting at Penn State University, USA, June 2022
Gary H. Perdew, Charlotte Esser, Megan Snyder, David H. Sherr, Ellen H. van den Bogaard, Karen McGovern, Pedro M. Fernández-Salguero, Xavier Coumoul, Andrew D. Patterson, 2023, International Journal of Molecular Sciences
Aryl hydrocarbon receptor activation affects nitrergic neuronal survival and delays intestinal motility in mice
Anitha Vijay, Nina R. Boyle, Supriya M. Kumar, Gary H. Perdew, Shanthi Srinivasan, Andrew D. Patterson, 2023, Toxicological Sciences on p. 117-128
Aryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming
Xiaoliang Zhou, Debopriya Chakraborty, Iain A. Murray, Denise Coslo, Zoe Kehs, Anitha Vijay, Carolyn Ton, Dhimant Desai, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2023, Laboratory Investigation on p. 100012
Jonathan A. Young, Silvana Duran-Ortiz, Stephen Bell, Kevin Funk, Yuan Tian, Qing Liu, Andrew D. Patterson, Edward O. List, Darlene E. Berryman, John J. Kopchick, 2023, Metabolites
Iain A. Murray, Andrew D. Patterson, Gary H. Perdew, 2014, Nature Reviews Cancer on p. 801-814
Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity
Fei Li, Changtao Jiang, Kristopher W. Krausz, Yunfei Li, Istvan Albert, Haiping Hao, Kristin M. Fabre, James B. Mitchell, Andrew D. Patterson, Frank J. Gonzalez, 2013, Nature Communications
Lulu Sun, Cen Xie, Guang Wang, Yue Wu, Qing Wu, Xuemei Wang, Jia Liu, Yangyang Deng, Jialin Xia, Bo Chen, Songyang Zhang, Chuyu Yun, Guan Lian, Xiujuan Zhang, Heng Zhang, William H. Bisson, Jingmin Shi, Xiaoxia Gao, Pupu Ge, Cuihua Liu, Kristopher W. Krausz, Robert G. Nichols, Jingwei Cai, Bipin Rimal, Andrew D. Patterson, Xian Wang, Frank J. Gonzalez, Changtao Jiang, 2018, Nature Medicine on p. 1919-1929
Changtao Jiang, Cen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jingwei Cai, Yunpeng Qi, Zhong Ze Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu G. Amin, Istvan Albert, Andrew D. Patterson, Frank J. Gonzalez, 2015, Journal of Clinical Investigation on p. 386-402
Changtao Jiang, Cen Xie, Ying Lv, Jing Li, Kristopher W. Krausz, Jingmin Shi, Chad N. Brocker, Dhimant Desai, Shantu G. Amin, William H. Bisson, Yulan Liu, Oksana Gavrilova, Andrew D. Patterson, Frank J. Gonzalez, 2015, Nature Communications
Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota
G Li, C Xie, S Lu, R Nichols, Yuan Tian, L Li, D Patel, Y Ma, C Brocker, T Yan, K Krausz, R Xiang, O Gavrilova, Andrew D. Patterson, F Gonzalez, 2017, Cell Metabolism on p. 672-685.e4
Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism
P Pathak, C Xie, R Nichols, J Ferrell, S Boehme, K Krausz, Andrew D. Patterson, F Gonzalez, Chiang JYL, John Y.L. Chiang, 2018, Hepatology on p. 1574-1588
Vishal Singh, Beng San Yeoh, Benoit Chassaing, Xia Xiao, Piu Saha, Rodrigo Aguilera Olvera, John D. Lapek, Limin Zhang, Wei Bei Wang, Sijie Hao, Michael D. Flythe, David J. Gonzalez, Patrice D. Cani, Jose R. Conejo-Garcia, Na Xiong, Mary J. Kennett, Bina Joe, Andrew D. Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2018, Cell on p. 679-694.e22
Qi Yan Ang, Margaret Alexander, John C. Newman, Yuan Tian, Jingwei Cai, Vaibhav Upadhyay, Jessie A. Turnbaugh, Eric Verdin, Kevin D. Hall, Rudolph L. Leibel, Eric Ravussin, Michael Rosenbaum, Andrew D. Patterson, Peter J. Turnbaugh, 2020, Cell on p. 1263-1275.e16
Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation
Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson, 2015, Environmental Health Perspectives on p. 679-688
News Articles Featuring Andrew Patterson
Aug 09, 2023
College of Ag Sciences scientist receives grant to study gut homeostasis, diet
Can plants evolved to resist infection help humans do the same?
Jul 19, 2023
Penn State researchers examine how environmental chemicals affect gut microbiome
Worldwide, high rates of obesity and other inflammatory conditions are associated with increased risk for cancer, cardiovascular disease and type 2 diabetes.
Apr 06, 2023
Broccoli consumption protects gut lining, reduces disease, in mice
Broccoli is known to be beneficial to our health. For example, research has shown that increased consumption of the cruciferous vegetable decreases incidences of cancer and type 2 diabetes.
Jan 12, 2023
Two College of Ag Sciences faculty among highly cited researchers in 2022
Andrew Patterson and Jonathan Lynch in Penn State’s College of Agricultural Sciences were recognized recently as highly cited researchers by the Clarivate Analytics Web of Science Group.
Sep 13, 2022
Microbiome Center announces inaugural Interdisciplinary Innovation Fellows
The Penn State Microbiome Center has named six recipients for its inaugural Interdisciplinary Innovation Fellowships (IIF) program, which aims to promote collaborative training opportunities for center members.
Sep 02, 2022
Metabolomics Core Facility continues to expand while pushing scientific bounds
Established nearly a decade ago, Penn State’s Metabolomics Core Facility is housed in the Huck Institutes of the Life Sciences on the University Park campus.
Feb 09, 2021
Andrew Patterson receives Society of Toxicology Achievement Award
The Society of Toxicology has named Tombros Early Career Professor Andrew Patterson of Penn State as the recipient of its 2021 Achievement Award, recognizing his significant contributions to the field of toxicology within 15 years of obtaining the highest earned degree.
Mar 11, 2020
Listening to your gut: A powerful new tool on the microbiome and cell metabolism
Many aspects of our lives — not only the presence or absence of certain diseases, but conditions like obesity, sleep patterns, even mood — may be determined, to a surprising extent, by the microbes living inside of us.
Jan 21, 2020
Persistent environmental contaminant changes the gut microbiome of mice
An industrial chemical — phased out since 2002, but previously used in stain and water-repellent products and firefighting foam — alters the gut microbiome of mice and could have implications for human health, according to an international team of researchers.