Andrew Patterson

Professor and Huck Chair of Molecular Toxicology; Faculty Oversight, Metabolomics Core Facility

Andrew Patterson

Research Summary

The Patterson lab is focused on understanding the host-metabolite-microbiome axis

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

These publication tags are generated from the output of this researcher. Click any tag below to view other Huck researchers working on the same topic.

Gastrointestinal Microbiome Obesity Intestines Glycine Ligands Microbiota Liver Metabolic Bile Acids And Salts Muricholic Acid Fermentation High Fat Diet Metformin Aryl Hydrocarbon Receptors Nutrition Ceramides Fats Anti Bacterial Agents Glucose Non Alcoholic Fatty Liver Disease Metabolic Diseases Inulin Therapeutics Insulin Resistance Fexaramine

Most Recent Publications

Xenobiotic Receptor-Mediated Toxicity

GH Perdew, IA Murray, JM Peters,

Individualized microbiotas dictate the impact of dietary fiber on colitis sensitivity

Erica Bonazzi, Alexis Bretin, Lucile Vigué, Fuhua Hao, Andrew D. Patterson, Andrew T. Gewirtz, Benoit Chassaing, 2024, Microbiome

The underappreciated diversity of bile acid modifications.

I Mohanty, H Mannochio-Russo, J Schweer, Y El Abiead, W Bittremieux, S Xing, R Schmid, S Zuffa, F Vasquez, V Muti, J Zemlin, O Tovar-Herrera, S Moraïs, D Desai, S Amin, I Koo, C Turck, I Mizrahi, P Kris-Etherton, K Petersen, J Fleming, T Huan, Andrew Patterson, D Siegel, L Hagey, M Wang, A Aron, P Dorrestein, 2024, Cell

Immune cell-intrinsic Ah receptor facilitates the expression of antimicrobial REG3G in the small intestine

Debopriya Chakraborty, Denise M. Coslo, Iain Alexander Murray, Anitha Vijay, Andrew David Patterson, Gary H. Perdew, 2024, FASEB Journal

Reverse metabolomics for the discovery of chemical structures from humans

Emily C. Gentry, Stephanie L. Collins, Morgan Panitchpakdi, Pedro Belda-Ferre, Allison K. Stewart, Marvic Carrillo Terrazas, Hsueh Han Lu, Simone Zuffa, Tingting Yan, Julian Avila-Pacheco, Damian R. Plichta, Allegra T. Aron, Mingxun Wang, Alan K. Jarmusch, Fuhua Hao, Mashette Syrkin-Nikolau, Hera Vlamakis, Ashwin N. Ananthakrishnan, Brigid S. Boland, Amy Hemperly, Niels Vande Casteele, Frank J. Gonzalez, Clary B. Clish, Ramnik J. Xavier, Hiutung Chu, Erin S. Baker, Andrew D. Patterson, Rob Knight, Dionicio Siegel, Pieter C. Dorrestein, 2024, Nature on p. 419-426

microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data

Simone Zuffa, Robin Schmid, Anelize Bauermeister, Paulo Wender Paulo, Andres M. Caraballo-Rodriguez, Yasin El Abiead, Allegra T. Aron, Emily C. Gentry, Jasmine Zemlin, Michael J. Meehan, Nicole E. Avalon, Robert H. Cichewicz, Ekaterina Buzun, Marvic Carrillo Terrazas, Chia Yun Hsu, Renee Oles, Adriana Vasquez Ayala, Jiaqi Zhao, Hiutung Chu, Mirte C.M. Kuijpers, Sara L. Jackrel, Fidele Tugizimana, Lerato Pertunia Nephali, Ian A. Dubery, Ntakadzeni Edwin Madala, Eduarda Antunes Moreira, Leticia Veras Costa-Lotufo, Norberto Peporine Lopes, Paula Rezende-Teixeira, Paula C. Jimenez, Bipin Rimal, Andrew D. Patterson, Matthew F. Traxler, Rita de Cassia Pessotti, Daniel Alvarado-Villalobos, Giselle Tamayo-Castillo, Priscila Chaverri, Efrain Escudero-Leyva, Luis Manuel Quiros-Guerrero, Alexandre Jean Bory, Juliette Joubert, Adriano Rutz, Jean Luc Wolfender, Pierre Marie Allard, Andreas Sichert, Sammy Pontrelli, Benjamin S. Pullman, Nuno Bandeira, William H. Gerwick, Katia Gindro, Josep Massana-Codina, Berenike C. Wagner, Karl Forchhammer, Daniel Petras, Nicole Aiosa, Neha Garg, Manuel Liebeke, Patric Bourceau, Kyo Bin Kang, Henna Gadhavi, Luiz Pedro Sorio de Carvalho, Mariana Silva dos Santos, Alicia Isabel Pérez-Lorente, Carlos Molina-Santiago, Diego Romero, Raimo Franke, Mark Brönstrup, Arturo Vera Ponce de León, Phillip Byron Pope, Sabina Leanti La Rosa, Giorgia La Barbera, Henrik M. Roager, Martin Frederik Laursen, Fabian Hammerle, Bianka Siewert, Ursula Peintner, Cuauhtemoc Licona-Cassani, Lorena Rodriguez-Orduña, Evelyn Rampler, Felina Hildebrand, Gunda Koellensperger, Harald Schoeny, Katharina Hohenwallner, Lisa Panzenboeck, Rachel Gregor, Ellis Charles O’Neill, Eve Tallulah Roxborough, Jane Odoi, Nicole J. Bale, Su Ding, Jaap S. Sinninghe Damsté, Xue Li Guan, Jerry J. Cui, Kou San Ju, Denise Brentan Silva, Fernanda Motta Ribeiro Silva, Gilvan Ferreira da Silva, Hector H.F. Koolen, Carlismari Grundmann, Jason A. Clement, Hosein Mohimani, Kirk Broders, Kerry L. McPhail, Sidnee E. Ober-Singleton, Christopher M. Rath, Daniel McDonald, Rob Knight, Mingxun Wang, Pieter C. Dorrestein, 2024, Nature Microbiology on p. 336-345

Bile salt hydrolase catalyses formation of amine-conjugated bile acids

Bipin Rimal, Stephanie Collins, Ceylan Tanes, Megan Granda, Imhoi Koo, E Rocha, Sumeet Solanka, M Granda, Nushrat Hoque, Sumeet Solanki, Nushrat Hoque, Emily Gentry, Tingting Yan, Emily Gentry, Jordan Bisanz, Imhoi Koo, Erin Reilly, Kristopher Krausz, Fuhua Hao, Dhimant Desai, Shantu Amin, Devendra Paudel, Edson Rocha, Vishal Singh, James Coleman, Tingting Yan, Min Kim, Yatrik Shah, Frank Gonzalez, Kyle Bittinger, Joseph Zackular, John Vanden Heuvel, Kristopher Krausz, A Patterson, Dhimant Desai, Shantu Amin, James Coleman, Yatrik Shah, Jordan Bisanz, Frank Gonzalez, John Heuvel, John P. Vanden Heuvel, Gary Wu, Babette Zemel, Pieter Dorrestein, Emily E. Weinert, Andrew Patterson, 2024, Nature on p. 859-863

Sex Dimorphic Effects of Bile Acid Metabolism in Liver Cancer in Mice.

R Golonka, B San Yeoh, P Saha, Y Tian, Chiang JYL, Andrew Patterson, A Gewirtz, B Joe, M Vijay-Kumar, 2024, Cellular and molecular gastroenterology and hepatology

Human Intestinal Microbiome Determines Individualized Inflammatory Response to Dietary Emulsifier Carboxymethylcellulose Consumption

Noëmie Daniel, Gary D. Wu, William Walters, Charlene Compher, Josephine Ni, Clara Delaroque, Lindsey Albenberg, Ruth E. Ley, Andrew D. Patterson, James D. Lewis, Andrew T. Gewirtz, Benoit Chassaing, 2024, Cellular and Molecular Gastroenterology and Hepatology on p. 315-318

Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer

Lulu Sun, Yi Zhang, Jie Cai, Bipin Rimal, Edson R. Rocha, James P. Coleman, Chenran Zhang, Robert G. Nichols, Yuhong Luo, Bora Kim, Yaozong Chen, Kristopher W. Krausz, Curtis C. Harris, Andrew D. Patterson, Zhipeng Zhang, Shogo Takahashi, Frank J. Gonzalez, 2023, Nature Communications

Most-Cited Papers

Aryl hydrocarbon receptor ligands in cancer: Friend and foe

Iain A. Murray, Andrew D. Patterson, Gary H. Perdew, 2014, Nature Reviews Cancer on p. 801-814

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

Lulu Sun, Cen Xie, Guang Wang, Yue Wu, Qing Wu, Xuemei Wang, Jia Liu, Yangyang Deng, Jialin Xia, Bo Chen, Songyang Zhang, Chuyu Yun, Guan Lian, Xiujuan Zhang, Heng Zhang, William H. Bisson, Jingmin Shi, Xiaoxia Gao, Pupu Ge, Cuihua Liu, Kristopher W. Krausz, Robert G. Nichols, Jingwei Cai, Bipin Rimal, Andrew D. Patterson, Xian Wang, Frank J. Gonzalez, Changtao Jiang, 2018, Nature Medicine on p. 1919-1929

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

Changtao Jiang, Cen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jingwei Cai, Yunpeng Qi, Zhong Ze Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu G. Amin, Istvan Albert, Andrew D. Patterson, Frank J. Gonzalez, 2015, Journal of Clinical Investigation on p. 386-402

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Changtao Jiang, Cen Xie, Ying Lv, Jing Li, Kristopher W. Krausz, Jingmin Shi, Chad N. Brocker, Dhimant Desai, Shantu G. Amin, William H. Bisson, Yulan Liu, Oksana Gavrilova, Andrew D. Patterson, Frank J. Gonzalez, 2015, Nature Communications

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota

G Li, C Xie, S Lu, R Nichols, Yuan Tian, L Li, D Patel, Y Ma, C Brocker, T Yan, K Krausz, R Xiang, O Gavrilova, Andrew D. Patterson, F Gonzalez, 2017, Cell Metabolism on p. 672-685.e4

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism

P Pathak, C Xie, R Nichols, J Ferrell, S Boehme, K Krausz, Andrew D. Patterson, F Gonzalez, Chiang JYL, John Y.L. Chiang, 2018, Hepatology on p. 1574-1588

Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer

Vishal Singh, Beng San Yeoh, Benoit Chassaing, Xia Xiao, Piu Saha, Rodrigo Aguilera Olvera, John D. Lapek, Limin Zhang, Wei Bei Wang, Sijie Hao, Michael D. Flythe, David J. Gonzalez, Patrice D. Cani, Jose R. Conejo-Garcia, Na Xiong, Mary J. Kennett, Bina Joe, Andrew D. Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2018, Cell on p. 679-694.e22

Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells

Qi Yan Ang, Margaret Alexander, John C. Newman, Yuan Tian, Jingwei Cai, Vaibhav Upadhyay, Jessie A. Turnbaugh, Eric Verdin, Kevin D. Hall, Rudolph L. Leibel, Eric Ravussin, Michael Rosenbaum, Andrew D. Patterson, Peter J. Turnbaugh, 2020, Cell on p. 1263-1275.e16

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew, 2015, Scientific Reports

An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease

Frank J. Gonzalez, Changtao Jiang, Andrew D. Patterson, 2016, Gastroenterology on p. 845-859

News Articles Featuring Andrew Patterson

Feb 28, 2024

New role for bacterial enzyme in gut metabolism revealed

Bile acids long have been known to play a role in human metabolism. Synthesized from cholesterol in the liver, bile acids are involved in digestive processes, particularly in absorbing fat.

Full Article

Feb 28, 2024

New tech harvests both magnetic and ultrasound energy to safely power medical implants

Researchers have developed an innovative dual energy harvesting technology that combines magnetic field and ultrasonic energy, their generating 300% higher power than the current state-of-the-art devices

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Feb 20, 2024

Dual-energy harvesting device could power future wireless medical implants

A new wireless charging device developed by Penn State scientists could dramatically improve powering capability for implants while still being safe for our bodies, the researchers said.

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Jan 05, 2024

The stories that defined 2023 for the One Health Microbiome Center

A list of the top 10 most popular Penn State News articles about the One Health Microbiome Center

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Nov 21, 2023

College of Ag Sciences recognizes faculty, staff for research achievements

Penn State’s College of Agricultural Sciences lauded outstanding accomplishments in research during the 2023 Research Awards Ceremony, held Nov. 1 at the Hintz Family Alumni Center on the University Park campus.

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Aug 09, 2023

College of Ag Sciences scientist receives grant to study gut homeostasis, diet

Can plants evolved to resist infection help humans do the same?

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Jul 19, 2023

Penn State researchers examine how environmental chemicals affect gut microbiome

Worldwide, high rates of obesity and other inflammatory conditions are associated with increased risk for cancer, cardiovascular disease and type 2 diabetes.

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Apr 06, 2023

Broccoli consumption protects gut lining, reduces disease, in mice

Broccoli is known to be beneficial to our health. For example, research has shown that increased consumption of the cruciferous vegetable decreases incidences of cancer and type 2 diabetes.

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Jan 12, 2023

Two College of Ag Sciences faculty among highly cited researchers in 2022

Andrew Patterson and Jonathan Lynch in Penn State’s College of Agricultural Sciences were recognized recently as highly cited researchers by the Clarivate Analytics Web of Science Group.

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Sep 13, 2022

Microbiome Center announces inaugural Interdisciplinary Innovation Fellows

The Penn State Microbiome Center has named six recipients for its inaugural Interdisciplinary Innovation Fellowships (IIF) program, which aims to promote collaborative training opportunities for center members.

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