Zhi-Chun Lai

Professor of Biology, Biochemistry and Molecular Biology; Emphasis Area Representative, Cell and Developmental Biology

Zhi-Chun Lai

Research Summary

Signal Transduction, Growth Control, and Cancer Genetics

Huck Institutes Affiliations

Links

Publication Tags

Growth Neoplasms Genes Drosophila Apoptosis Tumors Beta Catenin Palmitates Catenins Tumor Suppressor Genes Nonesterified Fatty Acids Micrornas Phosphotransferases Organ Size Proteins Cell Proliferation Connective Tissue Growth Factor Membranes Mutation Cell Membrane Breast Neoplasms Cell Survival Tumor Suppressor Proteins Cell Differentiation Tissue

Most Recent Papers

Dual role of a C-terminally truncated isoform of large tumor suppressor kinase 1 in the regulation of hippo signaling and tissue growth

Yurika Matsui, Yifan Zhang, Robert Paulson, Zhi-chun Lai, 2019, DNA and Cell Biology on p. 91-106

The defender against apoptotic cell death 1 gene is required for tissue growth and efficient N-glycosylation in Drosophila melanogaster

Yifan Zhang, Chang Cui, Zhi-chun Lai, 2016, Developmental biology on p. 186-195

Yap1 plays a protective role in suppressing free fatty acid-induced apoptosis and promoting beta-cell survival

Yaoting Deng, Yurika Matsui, Wenfei Pan, Qiu Li, Zhi-chun Lai, 2016, Protein and Cell on p. 362-372

Recent progress in studies of factors that elicit pancreatic β-cell expansion

Qiu Li, Zhi-chun Lai, 2014, Protein and Cell on p. 81-87

Mutation analysis of large tumor suppressor genes LATS1 and LATS2 supports a tumor suppressor role in human cancer

Tian Yu, John Bachman, Zhi-chun Lai, 2014, Protein and Cell on p. 6-11

LATS2 suppresses oncogenic Wnt signaling by disrupting β-Catenin/BCL9 interaction

Jiong Li, Xiaohong Chen, Xiangming Ding, Yingduan Cheng, Bin Zhao, Zhi-chun Lai, Khalid AlHezaimi, Razqallah Hakem, Kun Liang Guan, Cun Yu Wang, 2013, Cell Reports on p. 1650-1663

Mob as tumor suppressor is regulated by bantam microRNA through a feedback loop for tissue growth control

Yifan Zhang, Zhi-chun Lai, 2013, Biochemical and Biophysical Research Communications on p. 438-442

The Drosophila ortholog of breast cancer metastasis suppressor gene, dBrms1, is critical for developmental timing through regulating ecdysone signaling

Shilin Song, Yuan Yuan, Jinfeng Lu, Qi Li, Zuoyan Zhu, Qichang Fan, Youfang Xue, Zhi-chun Lai, Wenxia Zhang, 2013, Developmental biology on p. 344-350

Hippo activation through homodimerization and membrane association for growth inhibition and organ size control

Yaoting Deng, Yurika Matsui, Yifan Zhang, Zhi-chun Lai, 2013, Developmental biology on p. 152-159

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

Fa Xing Yu, Yifan Zhang, Hyun Woo Park, Jenna L. Jewell, Qian Chen, Yaoting Deng, Duojia Pan, Susan S. Taylor, Zhi-chun Lai, Kun Liang Guan, 2013, Genes and Development on p. 1223-1232

High-Impact Papers

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

Fa Xing Yu, Yifan Zhang, Hyun Woo Park, Jenna L. Jewell, Qian Chen, Yaoting Deng, Duojia Pan, Susan S. Taylor, Zhi-chun Lai, Kun Liang Guan, 2013, Genes and Development on p. 1223-1232

Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein

Bin Zhao, Joungmok Kim, Xin Ye, Zhi-chun Lai, Kun Liang Guan, 2009, Cancer Research on p. 1089-1098

Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila

Li Lun Ho, Xiaomu Wei, Takeshi Shimizu, Zhi-chun Lai, 2010, Developmental biology on p. 274-283

LATS2 suppresses oncogenic Wnt signaling by disrupting β-Catenin/BCL9 interaction

Jiong Li, Xiaohong Chen, Xiangming Ding, Yingduan Cheng, Bin Zhao, Zhi-chun Lai, Khalid AlHezaimi, Razqallah Hakem, Kun Liang Guan, Cun Yu Wang, 2013, Cell Reports on p. 1650-1663

Akt is negatively regulated by Hippo signaling for growth inhibition in Drosophila

Xin Ye, Yaoting Deng, Zhi-chun Lai, 2012, Developmental biology on p. 115-123

Mutation analysis of large tumor suppressor genes LATS1 and LATS2 supports a tumor suppressor role in human cancer

Tian Yu, John Bachman, Zhi-chun Lai, 2014, Protein and Cell on p. 6-11

Hippo activation through homodimerization and membrane association for growth inhibition and organ size control

Yaoting Deng, Yurika Matsui, Yifan Zhang, Zhi-chun Lai, 2013, Developmental biology on p. 152-159

Mob as tumor suppressor is regulated by bantam microRNA through a feedback loop for tissue growth control

Yifan Zhang, Zhi-chun Lai, 2013, Biochemical and Biophysical Research Communications on p. 438-442

Yap1 plays a protective role in suppressing free fatty acid-induced apoptosis and promoting beta-cell survival

Yaoting Deng, Yurika Matsui, Wenfei Pan, Qiu Li, Zhi-chun Lai, 2016, Protein and Cell on p. 362-372

The Drosophila ortholog of breast cancer metastasis suppressor gene, dBrms1, is critical for developmental timing through regulating ecdysone signaling

Shilin Song, Yuan Yuan, Jinfeng Lu, Qi Li, Zuoyan Zhu, Qichang Fan, Youfang Xue, Zhi-chun Lai, Wenxia Zhang, 2013, Developmental biology on p. 344-350