Zhi-Chun Lai
Emphasis Area Representative, Cell and Developmental Biology; Professor of Biology, Biochemistry and Molecular Biology
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319 Life Sciences Bldg
University Park, - zcl1@psu.edu
- 814-863-0479
Research Summary
Signal Transduction, Growth Control, and Cancer Genetics
Huck Affiliations
- Molecular, Cellular, and Integrative Biosciences
- Neuroscience Institute
- Center for Cellular Dynamics
Links
Most Recent Publications
Editor's note: Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein
Bin Zhao, Joungmok Kim, Xin Ye, Zhi Chun Lai, Kun Liang Guan, 2021, Cancer Research on p. 5583
Erratum: Efficient multiplexed genome engineering with a polycistronic tRNA and CRISPR guide-RNA reveals an important role of detonator in reproduction of Drosophila melanogaster (PLoS ONE (2021) 16:1 (e0245454) DOI: 10.1371/journal.pone.0245454)
Cristin Chon, Grace Chon, Yurika Matsui, Huiqing Zeng, Zhi Chun Lai, Aimin Liu, 2021, PLoS One
Efficient multiplexed genome engineering with a polycistronic tRNA and CRISPR guide-RNA reveals an important role of detonator in reproduction of Drosophila melanogaster
Cristin Chon, G Chon, Yurika Matsui, Huiqing Zeng, Zhi Chun Lai, Aimin Liu, 2021, PLoS One on p. e0245454
Erratum: LATS2 Suppresses Oncogenic Wnt Signaling by Disrupting β-Catenin/BCL9 Interaction (LATS2 Suppresses Oncogenic Wnt Signaling by Disrupting β-Catenin/BCL9 Interaction (2013) 5(6) (1650–1663), (S2211124713007213), (10.1016/j.celrep.2013.11.037))
Jiong Li, Xiaohong Chen, Xiangming Ding, Yingduan Cheng, Bin Zhao, Zhi chun Lai, Khalid Al Hezaimi, Razqallah Hakem, Kun liang Guan, Cun Yu Wang, 2020, Cell Reports
Drosophila models of pathogenic copynumber variant genes show global and nonneuronal defects during development
Tanzeen Yusuff, Matthew Jensen, Sneha Yennawar, Lucilla Pizzo, Siddharth Karthikeyan, Dagny J. Gould, Avik Sarker, Erika Gedvilaite, Yurika Matsui, Janani Iyer, Zhi Chun Lai, Santhosh Girirajan, 2020, PLoS Genetics
Yap1 promotes proliferation of transiently amplifying stress erythroid progenitors during erythroid regeneration
S Hao, Y Matsui, Zhi Chun Lai, Robert Paulson, 2019, Experimental Hematology on p. 42-54.e4
Dual role of a C-terminally truncated isoform of large tumor suppressor kinase 1 in the regulation of hippo signaling and tissue growth
Y Matsui, Y Zhang, Robert F. Paulson, Zhi Chun Lai, 2019, DNA and Cell Biology on p. 91-106
Bimolecular Fluorescence Complementation (BiFC) in Tissue Culture and in Developing Tissues of Drosophila to Study Protein-Protein Interactions
Yurika Matsui, Zhi Chun Lai, 2019, on p. 75-85
Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche
Siyang Hao, Jie Xiang, Dai-Chen Wu, James Fraser, Baiye Ruan, Jingwei Cai, Andrew D. Patterson, Zhi Chun Lai, Robert Paulson, 2019, Blood advances on p. 2205-2217
The defender against apoptotic cell death 1 gene is required for tissue growth and efficient N-glycosylation in Drosophila melanogaster
Yifan Zhang, Chang Cui, Zhi Chun Lai, 2016, Developmental Biology on p. 186-195
Most-Cited Papers
Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche
Siyang Hao, Jie Xiang, Dai-Chen Wu, James Fraser, Baiye Ruan, Jingwei Cai, Andrew D. Patterson, Zhi Chun Lai, Robert Paulson, 2019, Blood advances on p. 2205-2217
Yap1 plays a protective role in suppressing free fatty acid-induced apoptosis and promoting beta-cell survival
Yaoting Deng, Yurika Matsui, Wenfei Pan, Qiu Li, Zhi Chun Lai, 2016, Protein and Cell on p. 362-372
The defender against apoptotic cell death 1 gene is required for tissue growth and efficient N-glycosylation in Drosophila melanogaster
Yifan Zhang, Chang Cui, Zhi Chun Lai, 2016, Developmental Biology on p. 186-195
Drosophila models of pathogenic copynumber variant genes show global and nonneuronal defects during development
Tanzeen Yusuff, Matthew Jensen, Sneha Yennawar, Lucilla Pizzo, Siddharth Karthikeyan, Dagny J. Gould, Avik Sarker, Erika Gedvilaite, Yurika Matsui, Janani Iyer, Zhi Chun Lai, Santhosh Girirajan, 2020, PLoS Genetics
Yap1 promotes proliferation of transiently amplifying stress erythroid progenitors during erythroid regeneration
S Hao, Y Matsui, Zhi Chun Lai, Robert Paulson, 2019, Experimental Hematology on p. 42-54.e4
Efficient multiplexed genome engineering with a polycistronic tRNA and CRISPR guide-RNA reveals an important role of detonator in reproduction of Drosophila melanogaster
Cristin Chon, G Chon, Yurika Matsui, Huiqing Zeng, Zhi Chun Lai, Aimin Liu, 2021, PLoS One on p. e0245454
Dual role of a C-terminally truncated isoform of large tumor suppressor kinase 1 in the regulation of hippo signaling and tissue growth
Y Matsui, Y Zhang, Robert F. Paulson, Zhi Chun Lai, 2019, DNA and Cell Biology on p. 91-106
Bimolecular Fluorescence Complementation (BiFC) in Tissue Culture and in Developing Tissues of Drosophila to Study Protein-Protein Interactions
Yurika Matsui, Zhi Chun Lai, 2019, on p. 75-85
Erratum: LATS2 Suppresses Oncogenic Wnt Signaling by Disrupting β-Catenin/BCL9 Interaction (LATS2 Suppresses Oncogenic Wnt Signaling by Disrupting β-Catenin/BCL9 Interaction (2013) 5(6) (1650–1663), (S2211124713007213), (10.1016/j.celrep.2013.11.037))
Jiong Li, Xiaohong Chen, Xiangming Ding, Yingduan Cheng, Bin Zhao, Zhi chun Lai, Khalid Al Hezaimi, Razqallah Hakem, Kun liang Guan, Cun Yu Wang, 2020, Cell Reports
Editor's note: Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein
Bin Zhao, Joungmok Kim, Xin Ye, Zhi Chun Lai, Kun Liang Guan, 2021, Cancer Research on p. 5583
News Articles Featuring Zhi-Chun Lai
Jun 24, 2020
Genes affecting brains and brawn?
Genes located in "copy number variants" (CNVs) — parts of chromosomes that are missing in some individuals and duplicated in others — that are associated with neurodevelopmental disorders affect more than just brain development, according to new research..
Full Article