Zhi-Chun Lai

Emphasis Area Representative, Cell and Developmental Biology; Professor of Biology, Biochemistry and Molecular Biology

Zhi-Chun Lai

Research Summary

Signal Transduction, Growth Control, and Cancer Genetics

Huck Affiliations

Links

Publication Tags

Genes Growth Apoptosis Drosophila Proteins Neoplasms Palmitates Catenins Nonesterified Fatty Acids Drosophila Melanogaster Erythropoiesis Tumors Cell Proliferation Connective Tissue Growth Factor Phosphotransferases Genome Actins Clustered Regularly Interspaced Short Palindromic Repeats Guide Rna Growth Differentiation Factor 15 Cells Tumor Suppressor Genes Transfer Rna Beta Catenin Micrornas

Most Recent Papers

Efficient multiplexed genome engineering with a polycistronic tRNA and CRISPR guide-RNA reveals an important role of detonator in reproduction of Drosophila melanogaster

Cristin Chon, Grace Chon, Yurika Matsui, Huiqing Zeng, Zhi Chun Lai, Aimin Liu, 2021, PLoS One

Erratum

Jiong Li, Xiaohong Chen, Xiangming Ding, Yingduan Cheng, Bin Zhao, Zhi chun Lai, Khalid Al Hezaimi, Razqallah Hakem, Kun liang Guan, Cun Yu Wang, 2020, Cell Reports

Drosophila models of pathogenic copynumber variant genes show global and nonneuronal defects during development

Tanzeen Yusuff, Matthew Jensen, Sneha Yennawar, Lucilla Pizzo, Siddharth Karthikeyan, Dagny J. Gould, Avik Sarker, Erika Gedvilaite, Yurika Matsui, Janani Iyer, Zhi Chun Lai, Santhosh Girirajan, 2020, PLoS Genetics

Yap1 promotes proliferation of transiently amplifying stress erythroid progenitors during erythroid regeneration

Siyang Hao, Yurika Matsui, Zhi Chun Lai, Robert F. Paulson, 2019, Experimental Hematology on p. 42-54.e4

Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche

Siyang Hao, Jie Xiang, Dai Chen Wu, James W. Fraser, Baiye Ruan, Jingwei Cai, Andrew D. Patterson, Zhi Chun Lai, Robert F. Paulson, 2019, Blood advances on p. 2205-2217

Dual role of a C-terminally truncated isoform of large tumor suppressor kinase 1 in the regulation of hippo signaling and tissue growth

Yurika Matsui, Yifan Zhang, Robert F. Paulson, Zhi Chun Lai, 2019, DNA and Cell Biology on p. 91-106

Bimolecular Fluorescence Complementation (BiFC) in Tissue Culture and in Developing Tissues of Drosophila to Study Protein-Protein Interactions

Yurika Matsui, Zhi Chun Lai, 2019, on p. 75-85

The defender against apoptotic cell death 1 gene is required for tissue growth and efficient N-glycosylation in Drosophila melanogaster

Yifan Zhang, Chang Cui, Zhi Chun Lai, 2016, Developmental Biology on p. 186-195

Yap1 plays a protective role in suppressing free fatty acid-induced apoptosis and promoting beta-cell survival

Yaoting Deng, Yurika Matsui, Wenfei Pan, Qiu Li, Zhi Chun Lai, 2016, Protein and Cell on p. 362-372

Recent progress in studies of factors that elicit pancreatic β-cell expansion

Qiu Li, Zhi Chun Lai, 2014, Protein and Cell on p. 81-87

Most-Cited Papers

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

Fa Xing Yu, Yifan Zhang, Hyun Woo Park, Jenna L. Jewell, Qian Chen, Yaoting Deng, Duojia Pan, Susan S. Taylor, Zhi Chun Lai, Kun Liang Guan, 2013, Genes and Development on p. 1223-1232

LATS2 suppresses oncogenic Wnt signaling by disrupting β-Catenin/BCL9 interaction

Jiong Li, Xiaohong Chen, Xiangming Ding, Yingduan Cheng, Bin Zhao, Zhi Chun Lai, Khalid AlHezaimi, Razqallah Hakem, Kun Liang Guan, Cun Yu Wang, 2013, Cell Reports on p. 1650-1663

Akt is negatively regulated by Hippo signaling for growth inhibition in Drosophila

Xin Ye, Yaoting Deng, Zhi Chun Lai, 2012, Developmental Biology on p. 115-123

Mutation analysis of large tumor suppressor genes LATS1 and LATS2 supports a tumor suppressor role in human cancer

Tian Yu, John Bachman, Zhi Chun Lai, 2014, Protein and Cell on p. 6-11

Mutual regulation between Hippo signaling and actin cytoskeleton

Yurika Matsui, Zhi Chun Lai, 2013, Protein and Cell on p. 904-910

Evidence for a tumor suppressor role for the Large tumor suppressor genes LATS1 and LATS2 in human cancer

Tian Yu, John Bachman, Zhi Chun Lai, 2013, Genetics on p. 1193-1196

Hippo activation through homodimerization and membrane association for growth inhibition and organ size control

Yaoting Deng, Yurika Matsui, Yifan Zhang, Zhi Chun Lai, 2013, Developmental Biology on p. 152-159

Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche

Siyang Hao, Jie Xiang, Dai Chen Wu, James W. Fraser, Baiye Ruan, Jingwei Cai, Andrew D. Patterson, Zhi Chun Lai, Robert F. Paulson, 2019, Blood advances on p. 2205-2217

Yap1 plays a protective role in suppressing free fatty acid-induced apoptosis and promoting beta-cell survival

Yaoting Deng, Yurika Matsui, Wenfei Pan, Qiu Li, Zhi Chun Lai, 2016, Protein and Cell on p. 362-372

Mob as tumor suppressor is regulated by bantam microRNA through a feedback loop for tissue growth control

Yifan Zhang, Zhi Chun Lai, 2013, Biochemical and Biophysical Research Communications on p. 438-442