Zachary Szpiech
Assistant Professor of Biology
Research Summary
Population and evolutionary genetics, with applications to medical genetics, anthropology, and conservation
Huck Graduate Students
Huck Affiliations
Links
Publication Tags
Genome Population Asthma Genes Haplotypes Genetic Variation Loci History Mutation Whole Genome Sequencing Genomics Demography Precision Medicine Demographic History Macaca Mulatta National Heart, Lung, And Blood Institute (U.S.) Bronchodilator Agents Demographic Statistics Pharmaceutical Preparations Communication Mutant Proteins Effect Child Homozygote PharmacogeneticsMost Recent Publications
Evolution of genes involved in the unusual genitals of the bear macaque, Macaca arctoides
Laurie S. Stevison, Nick P. Bailey, Zachary A. Szpiech, Taylor E. Novak, Don J. Melnick, Ben J. Evans, Jeffrey D. Wall, 2022, Ecology and Evolution
A spatially aware likelihood test to detect sweeps from haplotype distributions
Michael DeGiorgio, Zachary A. Szpiech, 2022, PLoS Genetics
Application of a novel haplotype-based scan for local adaptation to study high-altitude adaptation in rhesus macaques
Zachary A. Szpiech, Taylor E. Novak, Nick P. Bailey, Laurie S. Stevison, 2021, Evolution Letters on p. 408-421
Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
Daniel Taliun, Daniel N. Harris, Michael D. Kessler, Jedidiah Carlson, Zachary A. Szpiech, Raul Torres, Sarah A.Gagliano Taliun, André Corvelo, Stephanie M. Gogarten, Hyun Min Kang, Achilleas N. Pitsillides, Jonathon LeFaive, Seung been Lee, Xiaowen Tian, Brian L. Browning, Sayantan Das, Anne Katrin Emde, Wayne E. Clarke, Douglas P. Loesch, Amol C. Shetty, Thomas W. Blackwell, Albert V. Smith, Quenna Wong, Xiaoming Liu, Matthew P. Conomos, Dean M. Bobo, François Aguet, Christine Albert, Alvaro Alonso, Kristin G. Ardlie, Dan E. Arking, Stella Aslibekyan, Paul L. Auer, John Barnard, R. Graham Barr, Lucas Barwick, Lewis C. Becker, Rebecca L. Beer, Emelia J. Benjamin, Lawrence F. Bielak, John Blangero, Michael Boehnke, Donald W. Bowden, Jennifer A. Brody, Esteban G. Burchard, Brian E. Cade, James F. Casella, Brandon Chalazan, Daniel I. Chasman, Yii Der Ida Chen, 2021, Nature on p. 290-299
Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations
Michelle Daya, Nicholas Rafaels, Tonya M. Brunetti, Sameer Chavan, Albert M. Levin, Aniket Shetty, Christopher R. Gignoux, Meher Preethi Boorgula, Genevieve Wojcik, Monica Campbell, Candelaria Vergara, Dara G. Torgerson, Victor E. Ortega, Ayo Doumatey, Henry Richard Johnston, Nathalie Acevedo, Maria Ilma Araujo, Pedro C. Avila, Gillian Belbin, Eugene Bleecker, Carlos Bustamante, Luis Caraballo, Alvaro Cruz, Georgia M. Dunston, Celeste Eng, Mezbah U. Faruque, Trevor S. Ferguson, Camila Figueiredo, Jean G. Ford, Weiniu Gan, Pierre Antoine Gourraud, Nadia N. Hansel, Ryan D. Hernandez, Edwin Francisco Herrera-Paz, Silvia Jiménez, Eimear E. Kenny, Jennifer Knight-Madden, Rajesh Kumar, Leslie A. Lange, Ethan M. Lange, Antoine Lizee, Pissamai Maul, Trevor Maul, Alvaro Mayorga, Deborah Meyers, Dan L. Nicolae, Timothy D. O’Connor, Ricardo Riccio Oliveira, Christopher O. Olopade, Zachary A. Szpiech, 2019, Nature Communications
Author Correction: Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations (Nature Communications, (2019), 10, 1, (880), 10.1038/s41467-019-08469-7)
Michelle Daya, Nicholas Rafaels, Tonya M. Brunetti, Sameer Chavan, Albert M. Levin, Aniket Shetty, Christopher R. Gignoux, Meher Preethi Boorgula, Genevieve Wojcik, Monica Campbell, Candelaria Vergara, Dara G. Torgerson, Victor E. Ortega, Ayo Doumatey, Henry Richard Johnston, Nathalie Acevedo, Maria Ilma Araujo, Pedro C. Avila, Gillian Belbin, Eugene Bleecker, Carlos Bustamante, Luis Caraballo, Alvaro Cruz, Georgia M. Dunston, Celeste Eng, Mezbah U. Faruque, Trevor S. Ferguson, Camila Figueiredo, Jean G. Ford, Weiniu Gan, Pierre Antoine Gourraud, Nadia N. Hansel, Ryan D. Hernandez, Edwin Francisco Herrera-Paz, Silvia Jiménez, Eimear E. Kenny, Jennifer Knight-Madden, Rajesh Kumar, Leslie A. Lange, Ethan M. Lange, Antoine Lizee, Pissamai Maul, Trevor Maul, Alvaro Mayorga, Deborah Meyers, Dan L. Nicolae, Timothy D. O’Connor, Ricardo Riccio Oliveira, Christopher O. Olopade, Zachary A. Szpiech, 2019, Nature Communications
Ancestry-Dependent Enrichment of Deleterious Homozygotes in Runs of Homozygosity
Zachary A. Szpiech, Angel C.Y. Mak, Marquitta J. White, Donglei Hu, Celeste Eng, Esteban G. Burchard, Ryan D. Hernandez, 2019, American Journal of Human Genetics on p. 747-762
Whole-Genome sequencing of pharmacogenetic drug response in racially diverse children with asthma
Angel C.Y. Mak, Marquitta J. White, Walter L. Eckalbar, Zachary A. Szpiech, Sam S. Oh, Maria Pino-Yanes, Donglei Hu, Paǵe Goddard, Scott Huntsman, Joshua Galanter, Ann Chen Wu, Blanca E. Himes, Soren Germer, Julia M. Vogel, Karen L. Bunting, Celeste Eng, Sandra Salazar, Kevin L. Keys, Jennifer Liberto, Thomas J. Nuckton, Thomas A. Nguyen, Dara G. Torgerson, Pui Yan Kwok, Albert M. Levin, Juan C. Celedón, Erick Forno, Hakon Hakonarson, Patrick M. Sleiman, Amber Dahlin, Kelan G. Tantisira, Scott T. Weiss, Denise Serebrisky, Emerita Brigino-Buenaventura, Harold J. Farber, Kelley Meade, Michael A. Lenoir, Pedro C. Avila, Saunak Sen, Shannon M. Thyne, William Rodriguez-Cintron, Cheryl A. Winkler, Andŕes Moreno-Estrada, Karla Sandoval, Jose R. Rodriguez-Santana, Rajesh Kumar, L. Keoki Williams, Nadav Ahituv, Elad Ziv, Max A. Seibold, Robert B. Darnell, Noah Zaitlen, Ryan D. Hernandez, Esteban G. Burchard, 2018, American Review of Respiratory Disease on p. 1552-1564
Human demographic history has amplified the effects of background selection across the genome
Raul Torres, Zachary A. Szpiech, Ryan D. Hernandez, 2018, PLoS Genetics
Optimized distributed systems achieve significant performance improvement on sorted merging of massive VCF files
Xiaobo Sun, Jingjing Gao, Peng Jin, Celeste Eng, Esteban G. Burchard, Terri H. Beaty, Ingo Ruczinski, Rasika Ann Mathias, Kathleen Barnes, Fusheng Wang, Zhaohui S. Qin, Kathleen C. Barnes, Meher Preethi Boorgula, Monica Campbell, Sameer Chavan, Jean G. Ford, Cassandra Foster, Li Gao, Nadia N. Hansel, Edward Horowitz, Lili Huang, Romina Ortiz, Joseph Potee, Nicholas Rafaels, Alan F. Scott, Margaret A. Taub, Candelaria Vergara, Yijuan Hu, Henry Richard Johnston, Albert M. Levin, Badri Padhukasahasram, L. Keoki Williams, Georgia M. Dunston, Mezbah U. Faruque, Eimear E. Kenny, Kimberly Gietzen, Mark Hansen, Rob Genuario, Dave Bullis, Cindy Lawley, Aniket Deshpande, Wendy E. Grus, Devin P. Locke, Marilyn G. Foreman, Pedro C. Avila, Leslie Grammer, Kwang Youn A. Kim, Rajesh Kumar, Robert Schleimer, Zachary A. Szpiech, 2018, GigaScience
Most-Cited Papers
Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
Daniel Taliun, Daniel N. Harris, Michael D. Kessler, Jedidiah Carlson, Zachary A. Szpiech, Raul Torres, Sarah A.Gagliano Taliun, André Corvelo, Stephanie M. Gogarten, Hyun Min Kang, Achilleas N. Pitsillides, Jonathon LeFaive, Seung been Lee, Xiaowen Tian, Brian L. Browning, Sayantan Das, Anne Katrin Emde, Wayne E. Clarke, Douglas P. Loesch, Amol C. Shetty, Thomas W. Blackwell, Albert V. Smith, Quenna Wong, Xiaoming Liu, Matthew P. Conomos, Dean M. Bobo, François Aguet, Christine Albert, Alvaro Alonso, Kristin G. Ardlie, Dan E. Arking, Stella Aslibekyan, Paul L. Auer, John Barnard, R. Graham Barr, Lucas Barwick, Lewis C. Becker, Rebecca L. Beer, Emelia J. Benjamin, Lawrence F. Bielak, John Blangero, Michael Boehnke, Donald W. Bowden, Jennifer A. Brody, Esteban G. Burchard, Brian E. Cade, James F. Casella, Brandon Chalazan, Daniel I. Chasman, Yii Der Ida Chen, 2021, Nature on p. 290-299
Selscan: An efficient multithreaded program to perform EHH-based scans for positive selection
Zachary A. Szpiech, Ryan D. Hernandez, 2014, Molecular Biology and Evolution on p. 2824-2827
Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens
Yohann Nédélec, Joaquín Sanz, Golshid Baharian, Zachary A. Szpiech, Alain Pacis, Anne Dumaine, Jean Christophe Grenier, Andrew Freiman, Aaron J. Sams, Steven Hebert, Ariane Pagé Sabourin, Francesca Luca, Ran Blekhman, Ryan D. Hernandez, Roger Pique-Regi, Jenny Tung, Vania Yotova, Luis B. Barreiro, 2016, Cell on p. 657-669.e21
Long runs of homozygosity are enriched for deleterious variation
Zachary A. Szpiech, Jishu Xu, Trevor J. Pemberton, Weiping Peng, Sebastian Zöllner, Noah A. Rosenberg, Jun Z. Li, 2013, American Journal of Human Genetics on p. 90-102
Whole-Genome sequencing of pharmacogenetic drug response in racially diverse children with asthma
Angel C.Y. Mak, Marquitta J. White, Walter L. Eckalbar, Zachary A. Szpiech, Sam S. Oh, Maria Pino-Yanes, Donglei Hu, Paǵe Goddard, Scott Huntsman, Joshua Galanter, Ann Chen Wu, Blanca E. Himes, Soren Germer, Julia M. Vogel, Karen L. Bunting, Celeste Eng, Sandra Salazar, Kevin L. Keys, Jennifer Liberto, Thomas J. Nuckton, Thomas A. Nguyen, Dara G. Torgerson, Pui Yan Kwok, Albert M. Levin, Juan C. Celedón, Erick Forno, Hakon Hakonarson, Patrick M. Sleiman, Amber Dahlin, Kelan G. Tantisira, Scott T. Weiss, Denise Serebrisky, Emerita Brigino-Buenaventura, Harold J. Farber, Kelley Meade, Michael A. Lenoir, Pedro C. Avila, Saunak Sen, Shannon M. Thyne, William Rodriguez-Cintron, Cheryl A. Winkler, Andŕes Moreno-Estrada, Karla Sandoval, Jose R. Rodriguez-Santana, Rajesh Kumar, L. Keoki Williams, Nadav Ahituv, Elad Ziv, Max A. Seibold, Robert B. Darnell, Noah Zaitlen, Ryan D. Hernandez, Esteban G. Burchard, 2018, American Review of Respiratory Disease on p. 1552-1564
High-resolution network biology: Connecting sequence with function
Colm J. Ryan, Peter Cimermančič, Zachary A. Szpiech, Andrej Sali, Ryan D. Hernandez, Nevan J. Krogan, 2013, Nature Reviews Genetics on p. 865-879
Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations
Michelle Daya, Nicholas Rafaels, Tonya M. Brunetti, Sameer Chavan, Albert M. Levin, Aniket Shetty, Christopher R. Gignoux, Meher Preethi Boorgula, Genevieve Wojcik, Monica Campbell, Candelaria Vergara, Dara G. Torgerson, Victor E. Ortega, Ayo Doumatey, Henry Richard Johnston, Nathalie Acevedo, Maria Ilma Araujo, Pedro C. Avila, Gillian Belbin, Eugene Bleecker, Carlos Bustamante, Luis Caraballo, Alvaro Cruz, Georgia M. Dunston, Celeste Eng, Mezbah U. Faruque, Trevor S. Ferguson, Camila Figueiredo, Jean G. Ford, Weiniu Gan, Pierre Antoine Gourraud, Nadia N. Hansel, Ryan D. Hernandez, Edwin Francisco Herrera-Paz, Silvia Jiménez, Eimear E. Kenny, Jennifer Knight-Madden, Rajesh Kumar, Leslie A. Lange, Ethan M. Lange, Antoine Lizee, Pissamai Maul, Trevor Maul, Alvaro Mayorga, Deborah Meyers, Dan L. Nicolae, Timothy D. O’Connor, Ricardo Riccio Oliveira, Christopher O. Olopade, Zachary A. Szpiech, 2019, Nature Communications
Human demographic history has amplified the effects of background selection across the genome
Raul Torres, Zachary A. Szpiech, Ryan D. Hernandez, 2018, PLoS Genetics
Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins
Katharine A. White, Diego Garrido Ruiz, Zachary A. Szpiech, Nicolas B. Strauli, Ryan D. Hernandez, Matthew P. Jacobson, Diane L. Barber, 2017, Science's STKE : signal transduction knowledge environment
Identifying tagging SNPs for African specific genetic variation from the African Diaspora Genome
Henry Richard Johnston, Yi Juan Hu, Jingjing Gao, Timothy D. O'Connor, Gonçalo R. Abecasis, Genevieve L. Wojcik, Christopher R. Gignoux, Pierre Antoine Gourraud, Antoine Lizee, Mark Hansen, Rob Genuario, Dave Bullis, Cindy Lawley, Eimear E. Kenny, Carlos Bustamante, Terri H. Beaty, Rasika A. Mathias, Kathleen C. Barnes, Zhaohui S. Qin, Meher Preethi Boorgula, Monica Campbell, Sameer Chavan, Jean G. Ford, Cassandra Foster, Li Gao, Nadia N. Hansel, Edward Horowitz, Lili Huang, Romina Ortiz, Joseph Potee, Nicholas Rafaels, Ingo Ruczinski, Alan F. Scott, Margaret A. Taub, Candelaria Vergara, Albert M. Levin, Badri Padhukasahasram, L. Keoki Williams, Georgia M. Dunston, Mezbah U. Faruque, Kimberly Gietzen, Aniket Deshpande, Wendy E. Grus, Devin P. Locke, Marilyn G. Foreman, Pedro C. Avila, Leslie Grammer, Kwang Youn A. Kim, Rajesh Kumar, Zachary A. Szpiech, 2017, Scientific Reports