Zachary Szpiech

Assistant Professor of Biology

Research Summary

Population and evolutionary genetics, with applications to medical genetics, anthropology, and conservation

Huck Graduate Students

Huck Affiliations

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Publication Tags

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Genome Population Haplotypes Genes Asthma Macaca Mulatta Genetic Variation Loci Mutation Genomics History Precision Medicine Gene Communication Histidine Local Adaptation National Heart, Lung, And Blood Institute (U.S.) Mutant Proteins Genotype Macrophages Whole Genome Sequencing Chromosomes Statistics Genetic Selection Single Nucleotide Polymorphism

Most Recent Publications

Zachary A. Szpiech, 2024, Bioinformatics

Genomes of the extinct Bachman's warbler show high divergence and no evidence of admixture with other extant Vermivora warblers

Andrew W. Wood, Zachary A. Szpiech, Irby J. Lovette, Brian Tilston Smith, David Toews, 2023, Current Biology on p. 2823-2829.e4

Daniel J. Cotter, Elyssa F. Hofgard, John Novembre, Zachary A. Szpiech, Noah A. Rosenberg, 2023, Genetics

Romain Laurent, Zachary A. Szpiech, Sergio S. da Costa, Valentin Thouzeau, Cesar A. Fortes-Lima, Françoise Dessarps-Freichey, Laure Lémée, José Utgé, Noah A. Rosenberg, Marlyse Baptista, Paul Verdu, 2023, eLife

Laurie S. Stevison, Nick P. Bailey, Zachary A. Szpiech, Taylor E. Novak, Don J. Melnick, Ben J. Evans, Jeffrey D. Wall, 2022, Ecology and Evolution

Michael DeGiorgio, Zachary A. Szpiech, 2022, PLoS Genetics

Zachary A. Szpiech, Taylor E. Novak, Nick P. Bailey, Laurie S. Stevison, 2021, Evolution Letters on p. 408-421

Daniel Taliun, Daniel N. Harris, Michael D. Kessler, Jedidiah Carlson, Zachary A. Szpiech, Raul Torres, Sarah A.Gagliano Taliun, André Corvelo, Stephanie M. Gogarten, Hyun Min Kang, Achilleas N. Pitsillides, Jonathon LeFaive, Seung been Lee, Xiaowen Tian, Brian L. Browning, Sayantan Das, Anne Katrin Emde, Wayne E. Clarke, Douglas P. Loesch, Amol C. Shetty, Thomas W. Blackwell, Albert V. Smith, Quenna Wong, Xiaoming Liu, Matthew P. Conomos, Dean M. Bobo, François Aguet, Christine Albert, Alvaro Alonso, Kristin G. Ardlie, Dan E. Arking, Stella Aslibekyan, Paul L. Auer, John Barnard, R. Graham Barr, Lucas Barwick, Lewis C. Becker, Rebecca L. Beer, Emelia J. Benjamin, Lawrence F. Bielak, John Blangero, Michael Boehnke, Donald W. Bowden, Jennifer A. Brody, Esteban G. Burchard, Brian E. Cade, James F. Casella, Brandon Chalazan, Daniel I. Chasman, Yii Der Ida Chen, 2021, Nature on p. 290-299

Michelle Daya, Nicholas Rafaels, Tonya M. Brunetti, Sameer Chavan, Albert M. Levin, Aniket Shetty, Christopher R. Gignoux, Meher Preethi Boorgula, Genevieve Wojcik, Monica Campbell, Candelaria Vergara, Dara G. Torgerson, Victor E. Ortega, Ayo Doumatey, Henry Richard Johnston, Nathalie Acevedo, Maria Ilma Araujo, Pedro C. Avila, Gillian Belbin, Eugene Bleecker, Carlos Bustamante, Luis Caraballo, Alvaro Cruz, Georgia M. Dunston, Celeste Eng, Mezbah U. Faruque, Trevor S. Ferguson, Camila Figueiredo, Jean G. Ford, Weiniu Gan, Pierre Antoine Gourraud, Nadia N. Hansel, Ryan D. Hernandez, Edwin Francisco Herrera-Paz, Silvia Jiménez, Eimear E. Kenny, Jennifer Knight-Madden, Rajesh Kumar, Leslie A. Lange, Ethan M. Lange, Antoine Lizee, Pissamai Maul, Trevor Maul, Alvaro Mayorga, Deborah Meyers, Dan L. Nicolae, Timothy D. O’Connor, Ricardo Riccio Oliveira, Christopher O. Olopade, Zachary A. Szpiech, 2019, Nature Communications

Michelle Daya, Nicholas Rafaels, Tonya M. Brunetti, Sameer Chavan, Albert M. Levin, Aniket Shetty, Christopher R. Gignoux, Meher Preethi Boorgula, Genevieve Wojcik, Monica Campbell, Candelaria Vergara, Dara G. Torgerson, Victor E. Ortega, Ayo Doumatey, Henry Richard Johnston, Nathalie Acevedo, Maria Ilma Araujo, Pedro C. Avila, Gillian Belbin, Eugene Bleecker, Carlos Bustamante, Luis Caraballo, Alvaro Cruz, Georgia M. Dunston, Celeste Eng, Mezbah U. Faruque, Trevor S. Ferguson, Camila Figueiredo, Jean G. Ford, Weiniu Gan, Pierre Antoine Gourraud, Nadia N. Hansel, Ryan D. Hernandez, Edwin Francisco Herrera-Paz, Silvia Jiménez, Eimear E. Kenny, Jennifer Knight-Madden, Rajesh Kumar, Leslie A. Lange, Ethan M. Lange, Antoine Lizee, Pissamai Maul, Trevor Maul, Alvaro Mayorga, Deborah Meyers, Dan L. Nicolae, Timothy D. O’Connor, Ricardo Riccio Oliveira, Christopher O. Olopade, Zachary A. Szpiech, 2019, Nature Communications

Most-Cited Papers

Daniel Taliun, Daniel N. Harris, Michael D. Kessler, Jedidiah Carlson, Zachary A. Szpiech, Raul Torres, Sarah A.Gagliano Taliun, André Corvelo, Stephanie M. Gogarten, Hyun Min Kang, Achilleas N. Pitsillides, Jonathon LeFaive, Seung been Lee, Xiaowen Tian, Brian L. Browning, Sayantan Das, Anne Katrin Emde, Wayne E. Clarke, Douglas P. Loesch, Amol C. Shetty, Thomas W. Blackwell, Albert V. Smith, Quenna Wong, Xiaoming Liu, Matthew P. Conomos, Dean M. Bobo, François Aguet, Christine Albert, Alvaro Alonso, Kristin G. Ardlie, Dan E. Arking, Stella Aslibekyan, Paul L. Auer, John Barnard, R. Graham Barr, Lucas Barwick, Lewis C. Becker, Rebecca L. Beer, Emelia J. Benjamin, Lawrence F. Bielak, John Blangero, Michael Boehnke, Donald W. Bowden, Jennifer A. Brody, Esteban G. Burchard, Brian E. Cade, James F. Casella, Brandon Chalazan, Daniel I. Chasman, Yii Der Ida Chen, 2021, Nature on p. 290-299

Zachary A. Szpiech, Ryan D. Hernandez, 2014, Molecular Biology and Evolution on p. 2824-2827

Yohann Nédélec, Joaquín Sanz, Golshid Baharian, Zachary A. Szpiech, Alain Pacis, Anne Dumaine, Jean Christophe Grenier, Andrew Freiman, Aaron J. Sams, Steven Hebert, Ariane Pagé Sabourin, Francesca Luca, Ran Blekhman, Ryan D. Hernandez, Roger Pique-Regi, Jenny Tung, Vania Yotova, Luis B. Barreiro, 2016, Cell on p. 657-669.e21

Angel C.Y. Mak, Marquitta J. White, Walter L. Eckalbar, Zachary A. Szpiech, Sam S. Oh, Maria Pino-Yanes, Donglei Hu, Paǵe Goddard, Scott Huntsman, Joshua Galanter, Ann Chen Wu, Blanca E. Himes, Soren Germer, Julia M. Vogel, Karen L. Bunting, Celeste Eng, Sandra Salazar, Kevin L. Keys, Jennifer Liberto, Thomas J. Nuckton, Thomas A. Nguyen, Dara G. Torgerson, Pui Yan Kwok, Albert M. Levin, Juan C. Celedón, Erick Forno, Hakon Hakonarson, Patrick M. Sleiman, Amber Dahlin, Kelan G. Tantisira, Scott T. Weiss, Denise Serebrisky, Emerita Brigino-Buenaventura, Harold J. Farber, Kelley Meade, Michael A. Lenoir, Pedro C. Avila, Saunak Sen, Shannon M. Thyne, William Rodriguez-Cintron, Cheryl A. Winkler, Andŕes Moreno-Estrada, Karla Sandoval, Jose R. Rodriguez-Santana, Rajesh Kumar, L. Keoki Williams, Nadav Ahituv, Elad Ziv, Max A. Seibold, Robert B. Darnell, Noah Zaitlen, Ryan D. Hernandez, Esteban G. Burchard, 2018, American Review of Respiratory Disease on p. 1552-1564

Michelle Daya, Nicholas Rafaels, Tonya M. Brunetti, Sameer Chavan, Albert M. Levin, Aniket Shetty, Christopher R. Gignoux, Meher Preethi Boorgula, Genevieve Wojcik, Monica Campbell, Candelaria Vergara, Dara G. Torgerson, Victor E. Ortega, Ayo Doumatey, Henry Richard Johnston, Nathalie Acevedo, Maria Ilma Araujo, Pedro C. Avila, Gillian Belbin, Eugene Bleecker, Carlos Bustamante, Luis Caraballo, Alvaro Cruz, Georgia M. Dunston, Celeste Eng, Mezbah U. Faruque, Trevor S. Ferguson, Camila Figueiredo, Jean G. Ford, Weiniu Gan, Pierre Antoine Gourraud, Nadia N. Hansel, Ryan D. Hernandez, Edwin Francisco Herrera-Paz, Silvia Jiménez, Eimear E. Kenny, Jennifer Knight-Madden, Rajesh Kumar, Leslie A. Lange, Ethan M. Lange, Antoine Lizee, Pissamai Maul, Trevor Maul, Alvaro Mayorga, Deborah Meyers, Dan L. Nicolae, Timothy D. O’Connor, Ricardo Riccio Oliveira, Christopher O. Olopade, Zachary A. Szpiech, 2019, Nature Communications

Raul Torres, Zachary A. Szpiech, Ryan D. Hernandez, 2018, PLoS Genetics

Katharine A. White, Diego Garrido Ruiz, Zachary A. Szpiech, Nicolas B. Strauli, Ryan D. Hernandez, Matthew P. Jacobson, Diane L. Barber, 2017, Science's STKE : signal transduction knowledge environment

Zachary A. Szpiech, Angel C.Y. Mak, Marquitta J. White, Donglei Hu, Celeste Eng, Esteban G. Burchard, Ryan D. Hernandez, 2019, American Journal of Human Genetics on p. 747-762

Zachary A. Szpiech, Taylor E. Novak, Nick P. Bailey, Laurie S. Stevison, 2021, Evolution Letters on p. 408-421

Henry Richard Johnston, Yi Juan Hu, Jingjing Gao, Timothy D. O'Connor, Gonçalo R. Abecasis, Genevieve L. Wojcik, Christopher R. Gignoux, Pierre Antoine Gourraud, Antoine Lizee, Mark Hansen, Rob Genuario, Dave Bullis, Cindy Lawley, Eimear E. Kenny, Carlos Bustamante, Terri H. Beaty, Rasika A. Mathias, Kathleen C. Barnes, Zhaohui S. Qin, Meher Preethi Boorgula, Monica Campbell, Sameer Chavan, Jean G. Ford, Cassandra Foster, Li Gao, Nadia N. Hansel, Edward Horowitz, Lili Huang, Romina Ortiz, Joseph Potee, Nicholas Rafaels, Ingo Ruczinski, Alan F. Scott, Margaret A. Taub, Candelaria Vergara, Albert M. Levin, Badri Padhukasahasram, L. Keoki Williams, Georgia M. Dunston, Mezbah U. Faruque, Kimberly Gietzen, Aniket Deshpande, Wendy E. Grus, Devin P. Locke, Marilyn G. Foreman, Pedro C. Avila, Leslie Grammer, Kwang Youn A. Kim, Rajesh Kumar, Zachary A. Szpiech, 2017, Scientific Reports