Yuguo (Leo) Lei

Associate Professor of Biomedical Engineering, Faculty Oversight, Sartorius Cell Culture Facility

Yuguo (Leo) Lei

Research Summary

Cell therapy; Cell manufacturing; Biomaterials

Huck Affiliations


Publication Tags

Stem Cells Hydrogels Hyaluronic Acid Polyethylene Glycol Dimethacrylate Hydrogel Cell Culture Dna Genes Skin Muscle Pluripotent Stem Cells Endothelial Cells Nanoparticles Fibronectins Cells Fibrin Tissue Brain Nanofibers Collagen Fibrinogen Scaffolds Proteins In Vitro Techniques Costs Polymers

Most Recent Papers

Comparative Study of Human Pluripotent Stem Cell-Derived Endothelial Cells in Hydrogel-Based Culture Systems

Zhanqi Wang, Fuxing Zuo, Qing Liu, Xuesheng Wu, Qian Du, Yuguo Lei, Zhangmin Wu, Haishuang Lin, 2021, ACS Omega on p. 6942-6952

Demonstration of re-epithelialization in a bioprinted human skin equivalent wound model

Carlos Poblete Jara, Carolina Motter Catarino, Yuguo Lei, Lício Augusto Velloso, Pankaj Karande, William H. Velander, Eliana Pereira de Araujo, 2021, Bioprinting

Amyloid precursor protein is a restriction factor that protects against Zika virus infection in mammalian brains

Amy Lingel, Haishuang Lin, Yuval Gavriel, Eric Weaver, Pascal Polepole, Virginia Lopez, Yuguo Lei, Thomas M. Petro, Beka Solomon, Chi Zhang, Luwen Zhang, 2020, Journal of Biological Chemistry on p. 17114-17127

Novel fibrin-fibronectin matrix accelerates mice skin wound healing

Carlos Poblete Jara, Ou Wang, Thais Paulino do Prado, Ayman Ismail, Frank Marco Fabian, Han Li, Licio A. Velloso, Mark A. Carlson, William Burgess, Yuguo Lei, William H. Velander, Eliana P. Araújo, 2020, Bioactive Materials on p. 949-962

Reversible associations between human plasma fibronectin and fibrinogen γγ’ heterodimer observed by high pressure size exclusion chromatography and dynamic light scattering

Frank M. Fabian, Ayman E.A. Ismail, Ou Wang, Yuguo Lei, William H. Velander, 2020, Analytical Biochemistry

Multi-scale modeling of the lamellar unit of arterial media

Hozhabr Mozafari, Lulu Wang, Yuguo Lei, Linxia Gu, 2020, Nanotechnology Reviews on p. 539-547

Engineered Microenvironment for Manufacturing Human Pluripotent Stem Cell-Derived Vascular Smooth Muscle Cells

Haishuang Lin, Xuefeng Qiu, Qian Du, Qiang Li, Ou Wang, Leonard Akert, Zhanqi Wang, Dirk Anderson, Kan Liu, Linxia Gu, Chi Zhang, Yuguo Lei, 2019, Stem Cell Reports on p. 84-97

Differentiating human pluripotent stem cells into vascular smooth muscle cells in three dimensional thermoreversible hydrogels

Haishuang Lin, Qian Du, Qiang Li, Ou Wang, Zhanqi Wang, Kan Liu, Leonard Akert, Chi Zhang, Soonkyu Chung, Bin Duan, Yuguo Lei, 2019, Biomaterials Science on p. 347-361

Manufacturing human pluripotent stem cell derived endothelial cells in scalable and cell-friendly microenvironments

Haishuang Lin, Qian Du, Qiang Li, Ou Wang, Zhanqi Wang, Christian Elowsky, Kan Liu, Chi Zhang, Soonkyu Chung, Bin Duan, Yuguo Lei, 2019, Biomaterials Science on p. 373-388

Integrated generation of induced pluripotent stem cells in a low-cost device

Haishuang Lin, Qiang Li, Qian Du, Ou Wang, Zhanqi Wang, Leonard Akert, Mark A. Carlson, Chi Zhang, Anuradha Subramanian, Chi Zhang, Matthew Lunning, Ming Li, Yuguo Lei, 2019, Biomaterials on p. 23-36

Most-Cited Papers

The spreading, migration and proliferation of mouse mesenchymal stem cells cultured inside hyaluronic acid hydrogels

Yuguo Lei, Shiva Gojgini, Jonathan Lam, Tatiana Segura, 2011, Biomaterials on p. 39-47

A fully defined and scalable 3D culture system for human pluripotent stem cell expansion and differentiation

Yuguo Lei, David V. Schaffer, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. E5039-E5048

Hyaluronic acid and fibrin hydrogels with concentrated DNA/PEI polyplexes for local gene delivery

Yuguo Lei, Maha Rahim, Quinn Ng, Tatiana Segura, 2011, Journal of Controlled Release on p. 255-261

Developing defined and scalable 3D culture systems for culturing human pluripotent stem cells at high densities

Yuguo Lei, Daeun Jeong, Jifang Xiao, David V. Schaffer, 2014, Cellular and Molecular Bioengineering on p. 172-183

Thermoreversible Hyaluronic Acid-PNIPAAm Hydrogel Systems for 3D Stem Cell Culture

Barbara L. Ekerdt, Christina M. Fuentes, Yuguo Lei, Maroof M. Adil, Anusuya Ramasubramanian, Rachel A. Segalman, David V. Schaffer, 2018, Advanced healthcare materials

Protein-polymer nanoparticles for nonviral gene delivery

Jianjun Zhang, Yuguo Lei, Anandika Dhaliwal, Quinn Kt Ng, Juanjuan Du, Ming Yan, Yunfeng Lu, Tatiana Segura, 2011, Biomacromolecules on p. 1006-1014

Design and characterization of microporous hyaluronic acid hydrogels for in vitro gene transfer to mMSCs

Talar Tokatlian, Cynthia Cam, Shayne N. Siegman, Yuguo Lei, Tatiana Segura, 2012, Acta Biomaterialia on p. 3921-3931

Three-dimensional tissues using human pluripotent stem cell spheroids as biofabrication building blocks

Haishuang Lin, Qiang Li, Yuguo Lei, 2017, Biofabrication

Establishment of a Human iPSC- and Nanofiber-Based Microphysiological Blood-Brain Barrier System

Dianjun Qi, Shaohua Wu, Haishuang Lin, Mitchell A. Kuss, Yuguo Lei, Alexey Krasnoslobodtsev, Shaheen Ahmed, Chi Zhang, Hyung Joon Kim, Peng Jiang, Bin Duan, 2018, ACS applied materials & interfaces on p. 21825-21835

Scalable Production of Glioblastoma Tumor-initiating Cells in 3 Dimension Thermoreversible Hydrogels

Qiang Li, Haishuang Lin, Ou Wang, Xuefeng Qiu, Srivatsan Kidambi, Loic P. Deleyrolle, Brent A. Reynolds, Yuguo Lei, 2016, Scientific Reports