Yuguo (Leo) Lei
Associate Professor of Biomedical Engineering; Faculty Oversight, Sartorius Cell Culture Facility
- 515 Chemical and Biomedical Engineering Building
- yxl6034@psu.edu
Research Summary
Cell therapy; Cell manufacturing; Biomaterials
Huck Affiliations
Links
Publication Tags
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Stem Cells Hydrogels Cell Culture Hydrogel Polyethylene Glycol Dimethacrylate Hydrogel Skin Pluripotent Stem Cells Alginate Cells Hyaluronic Acid Fibrin Tissue Application Nanofibers Cell Culture Techniques Alginates Reaction Yield Brown Fibronectins Poly N Isopropylacrylamide Drug Glioblastoma Brown Adipocytes Keratinocytes Neoplastic Stem CellsMost Recent Publications
Synergistic enhancement of the mouse Pramex1 and Pramel1 in repressing retinoic acid (RA) signaling during gametogenesis
Mingyao Yang, Francisco Diaz, Ana Rita T. Krause, Yuguo Lei, Wan Sheng Liu, 2024, Cell and Bioscience
Identification of RNA-based cell-type markers for stem-cell manufacturing systems with a statistical scoring function
Yu Shi, Weilong Yang, Haishuang Lin, Li Han, Alyssa J. Cai, Ravi Saraf, Yuguo Lei, Chi Zhang, 2024, Gene Reports
Mesenchymal stromal cells and alpha-1 antitrypsin have a strong synergy in modulating inflammation and its resolution
L Han, X Wu, O Wang, X Luan, W Velander, M Aynardi, E. Scott Halstead, A Bonavia, R Jin, G Li, Y Li, Y Wang, C Dong, Y Lei, 2023, Theranostics on p. 2843-2862
Nanoparticle-Decorated Biomimetic Extracellular Matrix for Cell Nanoencapsulation and Regulation
Kyungsene Lee, Brandon Davis, Xuelin Wang, Shubham Mirg, Connie Wen, Lidya Abune, Benjamin E. Peterson, Li Han, Haoyang Chen, Hongjun Wang, Spencer E. Szczesny, Yuguo Lei, Sri Rajasekhar Kothapalli, Yong Wang, 2023, Angewandte Chemie - International Edition on p. e202306583
Comparative study of differentiating human pluripotent stem cells into vascular smooth muscle cells in hydrogel-based culture methods
Qing Liu, Zhen Liu, Hongyu Gu, Yuxia Ge, Xuesheng Wu, Fuxing Zuo, Qian Du, Yuguo Lei, Zhanqi Wang, Haishuang Lin, 2023, Regenerative Therapy on p. 39-49
Fabricating 3-dimensional human brown adipose microtissues for transplantation studies
O Wang, L Han, H Lin, M Tian, S Zhang, B Duan, S Chung, C Zhang, Xiaojun Lian, Y Wang, Yuguo Lei, 2022, Bioactive Materials on p. 518-534
Isolating and cryopreserving pig skin cells for single-cell RNA sequencing study
Li Han, Carlos P. Jara, Ou Wang, Yu Shi, Xinran Wu, Sandra Thibivilliers, Rafał K. Wóycicki, Mark A. Carlson, William H. Velander, Eliana P. Araújo, Yuguo Lei, Marc Libault, Chi Zhang, 2022, PLoS One
Controllable fabrication of alginate/poly-L-ornithine polyelectrolyte complex hydrogel networks as therapeutic drug and cell carriers
Wen Xue, Bo Liu, Haipeng Zhang, Sangjin Ryu, Mitchell Kuss, Devanshi Shukla, Guoku Hu, Wen Shi, Xiping Jiang, Yuguo Lei, Bin Duan, 2022, Acta Biomaterialia on p. 182-192
Improving three-dimensional human pluripotent cell culture efficiency via surface molecule coating
Qiang Li, Ying Pan, Li Han, Yakun Yang, Xinran Wu, Yuguo Lei, 2022, Frontiers in Chemical Engineering
Demonstration of re-epithelialization in a bioprinted human skin equivalent wound model
Carlos Poblete Jara, Carolina Motter Catarino, Yuguo Lei, Lício Augusto Velloso, Pankaj Karande, William H. Velander, Eliana Pereira de Araujo, 2021, Bioprinting
Most-Cited Papers
Thermoreversible Hyaluronic Acid-PNIPAAm Hydrogel Systems for 3D Stem Cell Culture
Barbara L. Ekerdt, Christina M. Fuentes, Yuguo Lei, Maroof M. Adil, Anusuya Ramasubramanian, Rachel A. Segalman, David V. Schaffer, 2018, Advanced healthcare materials
Developing defined and scalable 3D culture systems for culturing human pluripotent stem cells at high densities
Yuguo Lei, Daeun Jeong, Jifang Xiao, David V. Schaffer, 2014, Cellular and Molecular Bioengineering on p. 172-183
Establishment of a Human iPSC- and Nanofiber-Based Microphysiological Blood-Brain Barrier System
Dianjun Qi, Shaohua Wu, Haishuang Lin, Mitchell A. Kuss, Yuguo Lei, Alexey Krasnoslobodtsev, Shaheen Ahmed, Chi Zhang, Hyung Joon Kim, Peng Jiang, Bin Duan, 2018, ACS applied materials & interfaces on p. 21825-21835
Effects of tunable, 3D-bioprinted hydrogels on human brown adipocyte behavior and metabolic function
Mitchell Kuss, Jiyoung Kim, Dianjun Qi, Shaohua Wu, Yuguo Lei, Soonkyu Chung, Bin Duan, 2018, Acta Biomaterialia on p. 486-495
Novel fibrin-fibronectin matrix accelerates mice skin wound healing
Carlos Poblete Jara, Ou Wang, Thais Paulino do Prado, Ayman Ismail, Frank Marco Fabian, Han Li, Licio A. Velloso, Mark A. Carlson, William Burgess, Yuguo Lei, William H. Velander, Eliana P. Araújo, 2020, Bioactive Materials on p. 949-962
Exosomes derived from differentiated human ADMSC with the Schwann cell phenotype modulate peripheral nerve-related cellular functions
Bo Liu, Yunfan Kong, Wen Shi, Mitchell Kuss, Ke Liao, Guoku Hu, Peng Xiao, Jagadesan Sankarasubramanian, Chittibabu Guda, Xinglong Wang, Yuguo Lei, Bin Duan, 2021, Bioactive Materials on p. 61-75
Scalable Culturing of Primary Human Glioblastoma Tumor-Initiating Cells with a Cell-Friendly Culture System
Qiang Li, Haishuang Lin, Jack Rauch, Loic P. Deleyrolle, Brent A. Reynolds, Hendrik J. Viljoen, Chi Zhang, Linxia Gu, Erika Van Wyk, Yuguo Lei, 2018, Scientific Reports
Scalable Production of Glioblastoma Tumor-initiating Cells in 3 Dimension Thermoreversible Hydrogels
Qiang Li, Haishuang Lin, Ou Wang, Xuefeng Qiu, Srivatsan Kidambi, Loic P. Deleyrolle, Brent A. Reynolds, Yuguo Lei, 2016, Scientific Reports
Scalable and physiologically relevant microenvironments for human pluripotent stem cell expansion and differentiation
Qiang Li, Haishuang Lin, Qian Du, Kan Liu, Ou Wang, Catelyn Evans, Hannah Christian, Chi Zhang, Yuguo Lei, 2018, Biofabrication
Hydrogel-Based Bioprocess for Scalable Manufacturing of Human Pluripotent Stem Cell-Derived Neural Stem Cells
Haishuang Lin, Qian Du, Qiang Li, Ou Wang, Zhanqi Wang, Kan Liu, Christian Elowsky, Chi Zhang, Yuguo Lei, 2018, ACS applied materials & interfaces on p. 29238--29250
News Articles Featuring Yuguo (Leo) Lei
Jan 27, 2021
Therapeutic cell researcher joins biomedical engineering and Huck Institutes
Yuguo “Leo” Lei joined the Penn State Department of Biomedical Engineering as an associate professor and the Huck Institutes of the Life Sciences as the inaugural faculty director of the Sartorius Cell Culture Facility in a joint appointment on Jan. 1.
Full Article
Jan 21, 2021
Sartorius Stedim Biotech’s $1.5M gift creates cell culture facility
Sartorius Stedim Biotech, a leading international partner of the biopharmaceutical industry, has committed $1.5 million to Penn State to create the Sartorius Cell Culture Facility, which will expand Penn State’s biotechnology ecosystem.
Full Article