Yuguo (Leo) Lei

Associate Professor of Biomedical Engineering, Faculty Oversight, Sartorius Cell Culture Facility

Yuguo (Leo) Lei

Research Summary

Cell therapy; Cell manufacturing; Biomaterials


Huck Affiliations

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Publication Tags

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Hydrogels Stem Cells Cell Culture Polyethylene Glycol Dimethacrylate Hydrogel Hydrogel Skin Pluripotent Stem Cells Alginate Cells Hyaluronic Acid Fibrin Tissue Application Nanofibers Cell Culture Techniques Cell Differentiation Alginates Reaction Yield Brown Fibronectins Poly N Isopropylacrylamide Drug Blood Brain Barrier Brown Adipocytes Glioblastoma

Most Recent Publications

Nanoparticle-Decorated Biomimetic Extracellular Matrix for Cell Nanoencapsulation and Regulation

Kyungsene Lee, Brandon Davis, Xuelin Wang, Shubham Mirg, Connie Wen, Lidya Abune, Benjamin E. Peterson, Li Han, Haoyang Chen, Hongjun Wang, Spencer E. Szczesny, Yuguo Lei, Sri Rajasekhar Kothapalli, Yong Wang, 2023, Angewandte Chemie - International Edition

Comparative study of differentiating human pluripotent stem cells into vascular smooth muscle cells in hydrogel-based culture methods

Qing Liu, Zhen Liu, Hongyu Gu, Yuxia Ge, Xuesheng Wu, Fuxing Zuo, Qian Du, Yuguo Lei, Zhanqi Wang, Haishuang Lin, 2023, Regenerative Therapy on p. 39-49

Mesenchymal stromal cells and alpha-1 antitrypsin have a strong synergy in modulating inflammation and its resolution

Li Han, Xinran Wu, Ou Wang, Xiao Luan, William H. Velander, Michael Aynardi, E. Scott Halstead, Anthony S. Bonavia, Rong Jin, Guohong Li, Yulong Li, Yong Wang, Cheng Dong, Yuguo Lei, 2023, Theranostics on p. 2843-2862

Fabricating 3-dimensional human brown adipose microtissues for transplantation studies

O Wang, L Han, H Lin, M Tian, S Zhang, B Duan, S Chung, C Zhang, Xiaojun Lian, Y Wang, Yuguo Lei, 2022, Bioactive Materials on p. 518-534

Improving three-dimensional human pluripotent cell culture efficiency via surface molecule coating

Qiang Li, Ying Pan, Li Han, Yakun Yang, Xinran Wu, Yuguo Lei, 2022, Front. Chem. Eng.

Exosomes derived from differentiated human ADMSC with the Schwann cell phenotype modulate peripheral nerve-related cellular functions

Bo Liu, Yunfan Kong, Wen Shi, Mitchell Kuss, Ke Liao, Guoku Hu, Peng Xiao, Jagadesan Sankarasubramanian, Chittibabu Guda, Xinglong Wang, Yuguo Lei, Bin Duan, 2022, Bioactive Materials on p. 61-75

Isolating and cryopreserving pig skin cells for single-cell RNA sequencing study

Li Han, Carlos P. Jara, Ou Wang, Yu Shi, Xinran Wu, Sandra Thibivilliers, Rafał K. Wóycicki, Mark A. Carlson, William H. Velander, Eliana P. Araújo, Yuguo Lei, Marc Libault, Chi Zhang, 2022, PLoS One

Controllable fabrication of alginate/poly-L-ornithine polyelectrolyte complex hydrogel networks as therapeutic drug and cell carriers

Wen Xue, Bo Liu, Haipeng Zhang, Sangjin Ryu, Mitchell Kuss, Devanshi Shukla, Guoku Hu, Wen Shi, Xiping Jiang, Yuguo Lei, Bin Duan, 2022, Acta Biomaterialia on p. 182-192

Demonstration of re-epithelialization in a bioprinted human skin equivalent wound model

Carlos Poblete Jara, Carolina Motter Catarino, Yuguo Lei, Lício Augusto Velloso, Pankaj Karande, William H. Velander, Eliana Pereira de Araujo, 2021, Bioprinting

Editorial: Stem Cell Systems Bioengineering

Yuguo Lei, S Willerth, T Fernandes, 2021, Frontiers in Bioengineering and Biotechnology on p. 693107

Most-Cited Papers

A fully defined and scalable 3D culture system for human pluripotent stem cell expansion and differentiation

Yuguo Lei, David V. Schaffer, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. E5039-E5048

Thermoreversible Hyaluronic Acid-PNIPAAm Hydrogel Systems for 3D Stem Cell Culture

Barbara L. Ekerdt, Christina M. Fuentes, Yuguo Lei, Maroof M. Adil, Anusuya Ramasubramanian, Rachel A. Segalman, David V. Schaffer, 2018, Advanced healthcare materials

Developing defined and scalable 3D culture systems for culturing human pluripotent stem cells at high densities

Yuguo Lei, Daeun Jeong, Jifang Xiao, David V. Schaffer, 2014, Cellular and Molecular Bioengineering on p. 172-183

Establishment of a Human iPSC- and Nanofiber-Based Microphysiological Blood-Brain Barrier System

Dianjun Qi, Shaohua Wu, Haishuang Lin, Mitchell A. Kuss, Yuguo Lei, Alexey Krasnoslobodtsev, Shaheen Ahmed, Chi Zhang, Hyung Joon Kim, Peng Jiang, Bin Duan, 2018, ACS applied materials & interfaces on p. 21825-21835

Effects of tunable, 3D-bioprinted hydrogels on human brown adipocyte behavior and metabolic function

Mitchell Kuss, Jiyoung Kim, Dianjun Qi, Shaohua Wu, Yuguo Lei, Soonkyu Chung, Bin Duan, 2018, Acta Biomaterialia on p. 486-495

Novel fibrin-fibronectin matrix accelerates mice skin wound healing

Carlos Poblete Jara, Ou Wang, Thais Paulino do Prado, Ayman Ismail, Frank Marco Fabian, Han Li, Licio A. Velloso, Mark A. Carlson, William Burgess, Yuguo Lei, William H. Velander, Eliana P. Araújo, 2020, Bioactive Materials on p. 949-962

Scalable Culturing of Primary Human Glioblastoma Tumor-Initiating Cells with a Cell-Friendly Culture System

Qiang Li, Haishuang Lin, Jack Rauch, Loic P. Deleyrolle, Brent A. Reynolds, Hendrik J. Viljoen, Chi Zhang, Linxia Gu, Erika Van Wyk, Yuguo Lei, 2018, Scientific Reports

Scalable Production of Glioblastoma Tumor-initiating Cells in 3 Dimension Thermoreversible Hydrogels

Qiang Li, Haishuang Lin, Ou Wang, Xuefeng Qiu, Srivatsan Kidambi, Loic P. Deleyrolle, Brent A. Reynolds, Yuguo Lei, 2016, Scientific Reports

Scalable and physiologically relevant microenvironments for human pluripotent stem cell expansion and differentiation

Qiang Li, Haishuang Lin, Qian Du, Kan Liu, Ou Wang, Catelyn Evans, Hannah Christian, Chi Zhang, Yuguo Lei, 2018, Biofabrication

Hydrogel-Based Bioprocess for Scalable Manufacturing of Human Pluripotent Stem Cell-Derived Neural Stem Cells

Haishuang Lin, Qian Du, Qiang Li, Ou Wang, Zhanqi Wang, Kan Liu, Christian Elowsky, Chi Zhang, Yuguo Lei, 2018, ACS applied materials & interfaces on p. 29238--29250