Yong Wang
Professor of Biomedical Engineering
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232 Hallowell Bldg
University Park, PA - yxw30@psu.edu
- 814-865-6867
Research Summary
Applying nature and biology as design guidelines to the creation of biomimetic and bioinspired materials at both the nanoscale and macroscale level for drug delivery, clinical diagnosis, and regenerative medicine.
Huck Affiliations
Publication Tags
Hydrogels Hydrogel Cells Intercellular Signaling Peptides And Proteins Proteins Surface Dna Application Molecular Recognition Polyethylene Glycol Dimethacrylate Hydrogel Biomimetics Protein Ligands Biomolecules Regenerative Medicine Skin Endonucleases Transducers Nanostructures Antibodies Nanomaterial Cell Membranes Communication Photoacoustic Microscopy Growth FactorMost Recent Publications
CCL27 is a crucial regulator of immune homeostasis of the skin and mucosal tissues
Micha L. Davila, Ming Xu, Chengyu Huang, Erin R. Gaddes, Levi Winter, Margherita T. Cantorna, Yong Wang, Na Xiong, 2022, iScience
Ultrasensitive detection of small biomolecules using aptamer-based molecular recognition and nanoparticle counting
Ruiting Xu, Lidya Abune, Brandon Davis, Leixin Ouyang, Ge Zhang, Yong Wang, Jiang Zhe, 2022, Biosensors and Bioelectronics
Bidirectional Supramolecular Display and Signal Amplification on the Surface of Living Cells
Brandon Davis, Peng Shi, Erin Gaddes, Jinping Lai, Yong Wang, 2022, Biomacromolecules on p. 1403-1412
Development of a Biomimetic Extracellular Matrix with Functions of Protein Sequestration and Cell Attachment Using Dual Aptamer-Functionalized Hydrogels
Lidya Abune, Kyungsene Lee, Yong Wang, 2022, ACS Biomaterials Science and Engineering on p. 1279-1289
Synthetic DNA for Cell Surface Engineering: Experimental Comparison between Click Conjugation and Lipid Insertion in Terms of Cell Viability, Engineering Efficiency, and Displaying Stability
Xuelin Wang, Connie Wen, Brandon Davis, Peng Shi, Lidya Abune, Kyungsene Lee, Cheng Dong, Yong Wang, 2022, ACS applied materials & interfaces on p. 3900-3909
Aptamer-functionalized hydrogels: An emerging class of biomaterials for protein delivery, cell capture, regenerative medicine, and molecular biosensing
Lidya Abune, Brandon Davis, Yong Wang, 2021, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Synthetic DNA for Cell-Surface Engineering
Peng Shi, Yong Wang, 2021, Angewandte Chemie - International Edition on p. 11580-11591
Affinity Hydrogels for Protein Delivery
Lidya Abune, Yong Wang, 2021, Trends in Pharmacological Sciences on p. 300-312
Psoriasis-associated impairment of CCL27/CCR10-derived regulation leads to IL-17A/IL-22–producing skin T-cell overactivation
Chao Li, Ming Xu, James Coyne, Wei Bei Wang, Micha L. Davila, Yong Wang, Na Xiong, 2021, Journal of Allergy and Clinical Immunology on p. 759-763.e9
CCL27/CCR10-derived regulatory signals suppress over-activation of IL-17A/IL-22-producing skin T cells and skin inflammation
Yong Wang, 2021, Journal of Allergy and Clinical Immunology. 2021. 147 (2), 759-763. e9
Most-Cited Papers
Endonuclease-responsive aptamer-functionalized hydrogel coating for sequential catch and release of cancer cells
Shihui Li, Niancao Chen, Zhaoyang Zhang, Yong Wang, 2013, Biomaterials on p. 460-469
Aptamer-functionalized superporous hydrogels for sequestration and release of growth factors regulated via molecular recognition
Mark R. Battig, Yike Huang, Niancao Chen, Yong Wang, 2014, Biomaterials on p. 8040-8048
Programmable hydrogels
Yong Wang, 2018, Biomaterials on p. 663-680
DNA-templated synthesis of biomimetic cell wall for nanoencapsulation and protection of mammalian cells
Peng Shi, Nan Zhao, James Coyne, Yong Wang, 2019, Nature Communications
Chimeric Aptamer-Gelatin Hydrogels as an Extracellular Matrix Mimic for Loading Cells and Growth Factors
Xiaolong Zhang, Mark R. Battig, Niancao Chen, Erin R. Gaddes, Katelyn L. Duncan, Yong Wang, 2016, Biomacromolecules on p. 778-787
Polyvalent Display of Biomolecules on Live Cells
Peng Shi, Nan Zhao, Jinping Lai, James Coyne, Erin R. Gaddes, Yong Wang, 2018, Angewandte Chemie - International Edition on p. 6800-6804
Assembly of Bifunctional Aptamer-Fibrinogen Macromer for VEGF Delivery and Skin Wound Healing
Nan Zhao, James Coyne, Ming Xu, Xiaolong Zhang, Akiho Suzuki, Peng Shi, Jinping Lai, Guo Hua Fong, Na Xiong, Yong Wang, 2019, Chemistry of Materials on p. 1006-1015
In Situ Synthesis of an Aptamer-Based Polyvalent Antibody Mimic on the Cell Surface for Enhanced Interactions between Immune and Cancer Cells
Peng Shi, Xuelin Wang, Brandon Davis, James Coyne, Cheng Dong, Joshua Reynolds, Yong Wang, 2020, Angewandte Chemie - International Edition on p. 11892-11897
Optical-resolution photoacoustic microscopy using transparent ultrasound transducer
Haoyang Chen, Sumit Agrawal, A Dangi, Christopher Wible, Mohamed Osman, Lidya Abune, Huizhen Jia, Randall Rossi, Yong Wang, Sri-Rajasekhar Kothapalli, 2019, Sensors on p. 5470
Aptamer-Based Polyvalent Ligands for Regulated Cell Attachment on the Hydrogel Surface
Erin R. Gaddes, Gregory Gydush, Shihui Li, Niancao Chen, Cheng Dong, Yong Wang, 2015, Biomacromolecules on p. 1382-1389
News Articles Featuring Yong Wang
Apr 20, 2020
Penn State engineer aims to tackle COVID-19 from two angles
To combat COVID-19 in both the treatment and testing arenas, Yong Wang, Penn State professor of biomedical engineering, has received two grants from the Huck Institutes of the Life Sciences COVID-19 multi-institute seed grant fund.
Full Article
Sep 23, 2019
Penn State researchers receive grant to explore novel method of anticoagulation
Two Penn State biomedical engineering faculty members have received a two-year, $200,000 grant from the American Heart Association (AHA) to explore potential solutions to thrombosis, or blood clot formation, a prevalent issue with blood-contacting medical devices such as heart valves, blood pumps and cardiac stents.
Full Article