Yong Wang
Professor of Biomedical Engineering

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232 Hallowell Bldg
University Park, PA - yxw30@psu.edu
- 814-865-6867
Research Summary
Applying nature and biology as design guidelines to the creation of biomimetic and bioinspired materials at both the nanoscale and macroscale level for drug delivery, clinical diagnosis, and regenerative medicine.
Huck Affiliations
Publication Tags
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Hydrogels Hydrogel Cells Intercellular Signaling Peptides And Proteins Molecular Recognition Proteins Biomimetics Surface Polyethylene Glycol Dimethacrylate Hydrogel Nanoparticles Application Dna Skin Transducers Extracellular Matrix Endonucleases Biomolecules Antibodies Protein Coatings Neoplasms Display Devices Growth Factor Oligonucleotides Photoacoustic MicroscopyMost Recent Publications
Nanoparticle-Decorated Biomimetic Extracellular Matrix for Cell Nanoencapsulation and Regulation
Kyungsene Lee, Brandon Davis, Xuelin Wang, Shubham Mirg, Connie Wen, Lidya Abune, Benjamin E. Peterson, Li Han, Haoyang Chen, Hongjun Wang, Spencer E. Szczesny, Yuguo Lei, Sri Rajasekhar Kothapalli, Yong Wang, 2023, Angewandte Chemie - International Edition
Deoxyribonucleic Acid-Based Polyvalent Ligand-Receptor Binding for Engineering the Cell Surface with Nanoparticles
Brandon Davis, Kyungsene Lee, Xuelin Wang, Yong Wang, 2023, Biomacromolecules on p. 3193-3202
Fibrin-Enriched Cardiac Extracellular Matrix Hydrogel Promotes In Vitro Angiogenesis
Rubia Shaik, Jiazhu Xu, Yong Wang, Yi Hong, Ge Zhang, 2023, ACS Biomaterials Science and Engineering on p. 877-888
Nanofluidic Aptamer Nanoarray to Enable Stochastic Capture of Single Proteins at Normal Concentrations
Jinbin Yang, Hiroki Kamai, Yong Wang, Yan Xu, 2023, Small
CCL27 is a crucial regulator of immune homeostasis of the skin and mucosal tissues
Micha L. Davila, Ming Xu, Chengyu Huang, Erin R. Gaddes, Levi Winter, Margherita T. Cantorna, Yong Wang, Na Xiong, 2022, iScience
Ultrasensitive detection of small biomolecules using aptamer-based molecular recognition and nanoparticle counting
Ruiting Xu, Lidya Abune, Brandon Davis, Leixin Ouyang, Ge Zhang, Yong Wang, Jiang Zhe, 2022, Biosensors and Bioelectronics
Bidirectional Supramolecular Display and Signal Amplification on the Surface of Living Cells
Brandon Davis, Peng Shi, Erin Gaddes, Jinping Lai, Yong Wang, 2022, Biomacromolecules on p. 1403-1412
Development of a Biomimetic Extracellular Matrix with Functions of Protein Sequestration and Cell Attachment Using Dual Aptamer-Functionalized Hydrogels
Lidya Abune, Kyungsene Lee, Yong Wang, 2022, ACS Biomaterials Science and Engineering on p. 1279-1289
Synthetic DNA for Cell Surface Engineering: Experimental Comparison between Click Conjugation and Lipid Insertion in Terms of Cell Viability, Engineering Efficiency, and Displaying Stability
Xuelin Wang, Connie Wen, Brandon Davis, Peng Shi, Lidya Abune, Kyungsene Lee, Cheng Dong, Yong Wang, 2022, ACS applied materials & interfaces on p. 3900-3909
Performance of a Hydrogel Coated Nitinol with Oligonucleotide-Modified Nanoparticles Within Turbulent Conditions of Blood-Contacting Devices
Connor Watson, Lidya Abune, Hicham Saaid, Connie Wen, Yong Wang, Keefe B. Manning, 2022, Cardiovascular Engineering and Technology
Most-Cited Papers
Endonuclease-responsive aptamer-functionalized hydrogel coating for sequential catch and release of cancer cells
Shihui Li, Niancao Chen, Zhaoyang Zhang, Yong Wang, 2013, Biomaterials on p. 460-469
Programmable hydrogels
Yong Wang, 2018, Biomaterials on p. 663-680
Aptamer-functionalized superporous hydrogels for sequestration and release of growth factors regulated via molecular recognition
Mark R. Battig, Yike Huang, Niancao Chen, Yong Wang, 2014, Biomaterials on p. 8040-8048
DNA-templated synthesis of biomimetic cell wall for nanoencapsulation and protection of mammalian cells
Peng Shi, Nan Zhao, James Coyne, Yong Wang, 2019, Nature Communications
In Situ Synthesis of an Aptamer-Based Polyvalent Antibody Mimic on the Cell Surface for Enhanced Interactions between Immune and Cancer Cells
Peng Shi, Xuelin Wang, Brandon Davis, James Coyne, Cheng Dong, Joshua Reynolds, Yong Wang, 2020, Angewandte Chemie - International Edition on p. 11892-11897
Chimeric Aptamer-Gelatin Hydrogels as an Extracellular Matrix Mimic for Loading Cells and Growth Factors
Xiaolong Zhang, Mark R. Battig, Niancao Chen, Erin R. Gaddes, Katelyn L. Duncan, Yong Wang, 2016, Biomacromolecules on p. 778-787
Polyvalent Display of Biomolecules on Live Cells
Peng Shi, Nan Zhao, Jinping Lai, James Coyne, Erin R. Gaddes, Yong Wang, 2018, Angewandte Chemie - International Edition on p. 6800-6804
Assembly of Bifunctional Aptamer-Fibrinogen Macromer for VEGF Delivery and Skin Wound Healing
Nan Zhao, James Coyne, Ming Xu, Xiaolong Zhang, Akiho Suzuki, Peng Shi, Jinping Lai, Guo Hua Fong, Na Xiong, Yong Wang, 2019, Chemistry of Materials on p. 1006-1015
Optical-resolution photoacoustic microscopy using transparent ultrasound transducer
Haoyang Chen, Sumit Agrawal, A Dangi, Christopher Wible, Mohamed Osman, Lidya Abune, Huizhen Jia, Randall Rossi, Yong Wang, Sri-Rajasekhar Kothapalli, 2019, Sensors on p. 5470
Affinity Hydrogels for Protein Delivery
Lidya Abune, Yong Wang, 2021, Trends in Pharmacological Sciences on p. 300-312
News Articles Featuring Yong Wang
Apr 20, 2020
Penn State engineer aims to tackle COVID-19 from two angles
To combat COVID-19 in both the treatment and testing arenas, Yong Wang, Penn State professor of biomedical engineering, has received two grants from the Huck Institutes of the Life Sciences COVID-19 multi-institute seed grant fund.
Full Article
Sep 23, 2019
Penn State researchers receive grant to explore novel method of anticoagulation
Two Penn State biomedical engineering faculty members have received a two-year, $200,000 grant from the American Heart Association (AHA) to explore potential solutions to thrombosis, or blood clot formation, a prevalent issue with blood-contacting medical devices such as heart valves, blood pumps and cardiac stents.
Full Article