Yasin Uzun
Assistant Professor of Pediatrics
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Room 207, 40 HMC Long Lane Hershey Medical Center
Hershey, PA 17036 - He, Him, His
- yxu5009@psu.edu
- (717) 531-0003 Ext: 284856
Research Summary
Developing and applying systems biology approaches to better understand gene regulation at the molecular level in development and disease by using single-cell genomic sequencing data.
Huck Affiliations
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Publication Tags
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Population Neoplasms Chromatin Epigenomics Genes T Lymphocytes Hematopoietic Stem Cells Automobiles Cell Line Leukemia Stem Cells Gene Regulatory Networks Cell And Tissue Based Therapy Steroid Neuroblastoma Plastic Property Hemangioblasts Transcriptome Double Stranded Rna Endothelium Endothelial Cells Precursor Cell Lymphoblastic Leukemia Lymphoma Quality Control Molecular Cluster EpigenomeMost Recent Publications
Targeting drug-resistant acute myeloid leukemia (AML) cells using novel casein kinase II (CK2) inhibitor
Koby Duke, Katherine Mercer, R Rajaiah, Muhammad Daniyal, Y Qiu, Ashok Purandare, Yasin Uzun, L Zhang, Morgann Klink, C Gowda, 2023, Cancer Research on p. 4004--4004
Integrating Single-Cell Methylome and Transcriptome Data with MAPLE
Yasin Uzun, Hao Wu, Kai Tan, 2023, on p. 43--54
Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis
Yiqing Yang, Melanie Mumau, Joanna Tober, Qin Zhu, Laura Bennett, Courtney Hong, Derek Sung, Thomas Keller, Yasin Uzun, Peng Gao, Swapnil Shewale, Mei Chen, Jisheng Yang, Xiaowen Chen, Steven A. Thomas, Kai Tan, Nancy A. Speck, Mark L. Kahn, 2022, Blood on p. 2942-2957
Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell–like blasts in KMT2A-rearranged leukemia
Changya Chen, Wenbao Yu, Fatemeh Alikarami, Qi Qiu, Chia hui Chen, Jennifer Flournoy, Peng Gao, Yasin Uzun, Li Fang, James W. Davenport, Yuxuan Hu, Qin Zhu, Kai Wang, Clara Libbrecht, Alex Felmeister, Isaiah Rozich, Yang yang Ding, Stephen P. Hunger, Carolyn A. Felix, Hao Wu, Patrick A. Brown, Erin M. Guest, David M. Barrett, Kathrin M. Bernt, Kai Tan, 2022, Blood on p. 2198-2211
MITI minimum information guidelines for highly multiplexed tissue images
Denis Schapiro, Clarence Yapp, Artem Sokolov, Sheila M. Reynolds, Yu An Chen, Damir Sudar, Yubin Xie, Jeremy Muhlich, Raquel Arias-Camison, Sarah Arena, Adam J. Taylor, Milen Nikolov, Madison Tyler, Jia Ren Lin, Erik A. Burlingame, Daniel L. Abravanel, Samuel Achilefu, Foluso O. Ademuyiwa, Andrew C. Adey, Rebecca Aft, Khung Jun Ahn, Fatemeh Alikarami, Shahar Alon, Orr Ashenberg, Ethan Baker, Gregory J. Baker, Shovik Bandyopadhyay, Peter Bayguinov, Jennifer Beane, Winston Becker, Kathrin Bernt, Courtney B. Betts, Julie Bletz, Tim Blosser, Adrienne Boire, Genevieve M. Boland, Edward S. Boyden, Elmar Bucher, Raphael Bueno, Qiuyin Cai, Francesco Cambuli, Joshua Campbell, Song Cao, Wagma Caravan, Ronan Chaligné, Joseph M. Chan, Sara Chasnoff, Deyali Chatterjee, Alyce A. Chen, Yasin Uzun, 2022, Nature Methods on p. 262-267
Epigenetic state determines inflammatory sensing in neuroblastoma
Adam J. Wolpaw, Liron D. Grossmann, Jessica L. Dessau, May M. Dong, Bailey J. Aaron, Patricia A. Brafford, Darya Volgina, Guillem Pascual-Pasto, Alba Rodriguez-Garcia, Yasin Uzun, Marie Arsenian-Henriksson, Daniel J. Powell, Kristopher R. Bosse, Andrew Kossenkov, Kai Tan, Michael D. Hogarty, John M. Maris, Chi V. Dang, 2022, Proceedings of the National Academy of Sciences of the United States of America
Defining therapeutic vulnerabilities of persister cells in high-risk neuroblastoma
Liron Grossmann, Yasin Uzun, Jarrett Lindsay, Chia-Hui Chen, Catherine Wingrove, Peng Gao, Anusha Thad, Adam Wolpaw, Nathan Kendserky, Smita Matkar, others, 2022,
NF-kB is a master regulator of resistance to therapy in high-risk neuroblastoma
Liron Grossmann, Yasin Uzun, Jarrett Lindsay, Chia-Hui Chen, Catherine Wingrove, Peng Gao, Anusha Thadi, Quinlen Marshall, Nathan Kendsersky, Lea Surrey, others, 2022, Cancer Research on p. 699--699
Longitudinal single-cell sequencing of high-risk neuroblastoma tumors reveals intrinsic and extrinsic mechanisms of therapy resistance
Yasin Uzun, Liron Grossmann, Chia-Hui Chen, Anusha Thadi, Chi-Yun Wu, Peng Gao, Dinh Diep, Lea Surrey, Daniel Martinez, Tasleema Patel, others, 2022, Cancer Research on p. 6051--6051
Integrative bulk and single-cell profiling of premanufacture t-cell populations reveals factors mediating long-term persistence of car t-cell therapy
Gregory M. Chen, Changya Chen, Rajat K. Das, Peng Gao, Chia Hui Chen, Shovik Bandyopadhyay, Yang Yang Ding, Yasin Uzun, Wenbao Yu, Qin Zhu, Regina M. Myers, Stephan A. Grupp, David M. Barrett, Kai Tan, 2021, Cancer Discovery on p. 2186-2199
Most-Cited Papers
The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution
Orit Rozenblatt-Rosen, Aviv Regev, Philipp Oberdoerffer, Tal Nawy, Anna Hupalowska, Jennifer E. Rood, Orr Ashenberg, Ethan Cerami, Robert J. Coffey, Emek Demir, Li Ding, Edward D. Esplin, James M. Ford, Jeremy Goecks, Sharmistha Ghosh, Joe W. Gray, Justin Guinney, Sean E. Hanlon, Shannon K. Hughes, E. Shelley Hwang, Christine A. Iacobuzio-Donahue, Judit Jané-Valbuena, Bruce E. Johnson, Ken S. Lau, Tracy Lively, Sarah A. Mazzilli, Dana Pe'er, Sandro Santagata, Alex K. Shalek, Denis Schapiro, Michael P. Snyder, Peter K. Sorger, Avrum E. Spira, Sudhir Srivastava, Kai Tan, Robert B. West, Elizabeth H. Williams, Denise Aberle, Samuel I. Achilefu, Foluso O. Ademuyiwa, Andrew C. Adey, Rebecca L. Aft, Rachana Agarwal, Ruben A. Aguilar, Fatemeh Alikarami, Viola Allaj, Christopher Amos, Robert A. Anders, Michael R. Angelo, Yasin Uzun, 2020, Cell on p. 236-249
Developmental trajectory of prehematopoietic stem cell formation from endothelium
Qin Zhu, Peng Gao, Joanna Tober, Laura Bennett, Changya Chen, Yasin Uzun, Yan Li, Elizabeth D. Howell, Melanie Mumau, Wenbao Yu, Bing He, Nancy A. Speck, Kai Tan, 2020, Blood on p. 845-856
Integrative bulk and single-cell profiling of premanufacture t-cell populations reveals factors mediating long-term persistence of car t-cell therapy
Gregory M. Chen, Changya Chen, Rajat K. Das, Peng Gao, Chia Hui Chen, Shovik Bandyopadhyay, Yang Yang Ding, Yasin Uzun, Wenbao Yu, Qin Zhu, Regina M. Myers, Stephan A. Grupp, David M. Barrett, Kai Tan, 2021, Cancer Discovery on p. 2186-2199
Identifying noncoding risk variants using disease-relevant gene regulatory networks
Long Gao, Yasin Uzun, Peng Gao, Bing He, Xiaoke Ma, Jiahui Wang, Shizhong Han, Kai Tan, 2018, Nature Communications
Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells
Peng Gao, Changya Chen, Elizabeth D. Howell, Yan Li, Joanna Tober, Yasin Uzun, Bing He, Long Gao, Qin Zhu, Arndt F. Siekmann, Nancy A. Speck, Kai Tan, 2020, Genes and Development
Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell–like blasts in KMT2A-rearranged leukemia
Changya Chen, Wenbao Yu, Fatemeh Alikarami, Qi Qiu, Chia hui Chen, Jennifer Flournoy, Peng Gao, Yasin Uzun, Li Fang, James W. Davenport, Yuxuan Hu, Qin Zhu, Kai Wang, Clara Libbrecht, Alex Felmeister, Isaiah Rozich, Yang yang Ding, Stephen P. Hunger, Carolyn A. Felix, Hao Wu, Patrick A. Brown, Erin M. Guest, David M. Barrett, Kathrin M. Bernt, Kai Tan, 2022, Blood on p. 2198-2211
Risk variants disrupting enhancers of T<sub>H</sub>1 and T<sub>REG</sub> cells in type 1 diabetes
Peng Gao, Yasin Uzun, Bing He, Sarah E. Salamati, Julie K.M. Coffey, Eva Tsalikian, Kai Tan, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 7581-7590
MITI minimum information guidelines for highly multiplexed tissue images
Denis Schapiro, Clarence Yapp, Artem Sokolov, Sheila M. Reynolds, Yu An Chen, Damir Sudar, Yubin Xie, Jeremy Muhlich, Raquel Arias-Camison, Sarah Arena, Adam J. Taylor, Milen Nikolov, Madison Tyler, Jia Ren Lin, Erik A. Burlingame, Daniel L. Abravanel, Samuel Achilefu, Foluso O. Ademuyiwa, Andrew C. Adey, Rebecca Aft, Khung Jun Ahn, Fatemeh Alikarami, Shahar Alon, Orr Ashenberg, Ethan Baker, Gregory J. Baker, Shovik Bandyopadhyay, Peter Bayguinov, Jennifer Beane, Winston Becker, Kathrin Bernt, Courtney B. Betts, Julie Bletz, Tim Blosser, Adrienne Boire, Genevieve M. Boland, Edward S. Boyden, Elmar Bucher, Raphael Bueno, Qiuyin Cai, Francesco Cambuli, Joshua Campbell, Song Cao, Wagma Caravan, Ronan Chaligné, Joseph M. Chan, Sara Chasnoff, Deyali Chatterjee, Alyce A. Chen, Yasin Uzun, 2022, Nature Methods on p. 262-267
ScATAC-pro: A comprehensive workbench for single-cell chromatin accessibility sequencing data
Wenbao Yu, Yasin Uzun, Qin Zhu, Changya Chen, Kai Tan, 2020, Genome Biology
Epigenetic state determines inflammatory sensing in neuroblastoma
Adam J. Wolpaw, Liron D. Grossmann, Jessica L. Dessau, May M. Dong, Bailey J. Aaron, Patricia A. Brafford, Darya Volgina, Guillem Pascual-Pasto, Alba Rodriguez-Garcia, Yasin Uzun, Marie Arsenian-Henriksson, Daniel J. Powell, Kristopher R. Bosse, Andrew Kossenkov, Kai Tan, Michael D. Hogarty, John M. Maris, Chi V. Dang, 2022, Proceedings of the National Academy of Sciences of the United States of America