Yasin Uzun

Assistant Professor of Pediatrics

Room 207, 40 HMC Long Lane Hershey Medical Center
Hershey, PA 17036
He, Him, His
yxu5009@psu.edu
(717) 531-0003 Ext: 284856

Bio & Links
Publications

Research Summary

Developing and applying systems biology approaches to better understand gene regulation at the molecular level in development and disease by using single-cell genomic sequencing data.

Huck Affiliations

Bioinformatics and Genomics

Publication Tags

These publication tags are generated from the output of this researcher. Click any tag below to view other Huck researchers working on the same topic.

Population Neoplasms Chromatin Epigenomics Genes Hematopoietic Stem Cells Cell Line Leukemia Gene Regulatory Networks Stem Cells Steroid Neuroblastoma Plastic Property Hemangioblasts Transcriptome Double Stranded Rna T Lymphocytes Endothelium Endothelial Cells Precursor Cell Lymphoblastic Leukemia Lymphoma Quality Control Molecular Cluster Epigenome Enhancer Single Cell Analysis

Most Recent Publications

ER stress elicits non-canonical CASP8 (caspase 8) activation on autophagosomal membranes to induce apoptosis

Tatsuya Hattori, Kevin A. Fundora, Kouta Hamamoto, David M. Opozda, Xinwen Liang, Xiaoming Liu, Jiawen Zhang, Yasin Uzun, Yoshinori Takahashi, Hong Gang Wang, 2024, Autophagy on p. 349-364

Integrating Single-Cell Methylome and Transcriptome Data with MAPLE

Yasin Uzun, Hao Wu, Kai Tan, 2023, on p. 43--54

Targeting drug-resistant acute myeloid leukemia (AML) cells using novel casein kinase II (CK2) inhibitor

Koby Duke, Katherine Mercer, R Rajaiah, Muhammad Daniyal, Y Qiu, Ashok Purandare, Yasin Uzun, L Zhang, Morgann Klink, C Behura, 2023, Cancer Research on p. 4004--4004

Isolation of Epithelial and Stromal Cells from Colon Tissues in Homeostasis and Under Inflammatory Conditions

Clara Morral, Reem Ghinnagow, Tatiana Karakasheva, Yusen Zhou, Anusha Thadi, Ning Li, Benjamin Yoshor, Gloria E. Soto, Chia Hui Chen, Daniel Aleynick, Sarah Weinbrom, Mary Kate Fulton, Yasin Uzun, Meenakshi Bewtra, Judith R. Kelsen, Christopher J. Lengner, Kai Tan, Andy J. Minn, Kathryn E. Hamilton, 2023, Bio-protocol

Ncrna-a3 Epigenetically Regulates TAL1 and Its Target Genes to Drive Erythroid Differentiation

Meghana Matur, Yasin Uzun, Y Qiu, S Huang, 2023, Blood on p. 1077

Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis

Yiqing Yang, Melanie Mumau, Joanna Tober, Qin Zhu, Laura Bennett, Courtney Hong, Derek Sung, Thomas Keller, Yasin Uzun, Peng Gao, Swapnil Shewale, Mei Chen, Jisheng Yang, Xiaowen Chen, Steven A. Thomas, Kai Tan, Nancy A. Speck, Mark L. Kahn, 2022, Blood on p. 2942-2957

Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell–like blasts in KMT2A-rearranged leukemia

Changya Chen, Wenbao Yu, Fatemeh Alikarami, Qi Qiu, Chia hui Chen, Jennifer Flournoy, Peng Gao, Yasin Uzun, Li Fang, James W. Davenport, Yuxuan Hu, Qin Zhu, Kai Wang, Clara Libbrecht, Alex Felmeister, Isaiah Rozich, Yang yang Ding, Stephen P. Hunger, Carolyn A. Felix, Hao Wu, Patrick A. Brown, Erin M. Guest, David M. Barrett, Kathrin M. Bernt, Kai Tan, 2022, Blood on p. 2198-2211

MITI minimum information guidelines for highly multiplexed tissue images

Denis Schapiro, Clarence Yapp, Artem Sokolov, Sheila M. Reynolds, Yu An Chen, Damir Sudar, Yubin Xie, Jeremy Muhlich, Raquel Arias-Camison, Sarah Arena, Adam J. Taylor, Milen Nikolov, Madison Tyler, Jia Ren Lin, Erik A. Burlingame, Daniel L. Abravanel, Samuel Achilefu, Foluso O. Ademuyiwa, Andrew C. Adey, Rebecca Aft, Khung Jun Ahn, Fatemeh Alikarami, Shahar Alon, Orr Ashenberg, Ethan Baker, Gregory J. Baker, Shovik Bandyopadhyay, Peter Bayguinov, Jennifer Beane, Winston Becker, Kathrin Bernt, Courtney B. Betts, Julie Bletz, Tim Blosser, Adrienne Boire, Genevieve M. Boland, Edward S. Boyden, Elmar Bucher, Raphael Bueno, Qiuyin Cai, Francesco Cambuli, Joshua Campbell, Song Cao, Wagma Caravan, Ronan Chaligné, Joseph M. Chan, Sara Chasnoff, Deyali Chatterjee, Alyce A. Chen, Yasin Uzun, 2022, Nature Methods on p. 262-267

Epigenetic state determines inflammatory sensing in neuroblastoma

Adam J. Wolpaw, Liron D. Grossmann, Jessica L. Dessau, May M. Dong, Bailey J. Aaron, Patricia A. Brafford, Darya Volgina, Guillem Pascual-Pasto, Alba Rodriguez-Garcia, Yasin Uzun, Marie Arsenian-Henriksson, Daniel J. Powell, Kristopher R. Bosse, Andrew Kossenkov, Kai Tan, Michael D. Hogarty, John M. Maris, Chi V. Dang, 2022, Proceedings of the National Academy of Sciences of the United States of America

Defining therapeutic vulnerabilities of persister cells in high-risk neuroblastoma

Liron Grossmann, Yasin Uzun, Jarrett Lindsay, Chia-Hui Chen, Catherine Wingrove, Peng Gao, Anusha Thad, Adam Wolpaw, Nathan Kendserky, Smita Matkar, others, 2022,

Most-Cited Papers

The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

Orit Rozenblatt-Rosen, Aviv Regev, Philipp Oberdoerffer, Tal Nawy, Anna Hupalowska, Jennifer E. Rood, Orr Ashenberg, Ethan Cerami, Robert J. Coffey, Emek Demir, Li Ding, Edward D. Esplin, James M. Ford, Jeremy Goecks, Sharmistha Ghosh, Joe W. Gray, Justin Guinney, Sean E. Hanlon, Shannon K. Hughes, E. Shelley Hwang, Christine A. Iacobuzio-Donahue, Judit Jané-Valbuena, Bruce E. Johnson, Ken S. Lau, Tracy Lively, Sarah A. Mazzilli, Dana Pe'er, Sandro Santagata, Alex K. Shalek, Denis Schapiro, Michael P. Snyder, Peter K. Sorger, Avrum E. Spira, Sudhir Srivastava, Kai Tan, Robert B. West, Elizabeth H. Williams, Denise Aberle, Samuel I. Achilefu, Foluso O. Ademuyiwa, Andrew C. Adey, Rebecca L. Aft, Rachana Agarwal, Ruben A. Aguilar, Fatemeh Alikarami, Viola Allaj, Christopher Amos, Robert A. Anders, Michael R. Angelo, Yasin Uzun, 2020, Cell on p. 236-249

Developmental trajectory of prehematopoietic stem cell formation from endothelium

Qin Zhu, Peng Gao, Joanna Tober, Laura Bennett, Changya Chen, Yasin Uzun, Yan Li, Elizabeth D. Howell, Melanie Mumau, Wenbao Yu, Bing He, Nancy A. Speck, Kai Tan, 2020, Blood on p. 845-856

Integrative bulk and single-cell profiling of premanufacture t-cell populations reveals factors mediating long-term persistence of car t-cell therapy

Gregory M. Chen, Changya Chen, Rajat K. Das, Peng Gao, Chia Hui Chen, Shovik Bandyopadhyay, Yang Yang Ding, Yasin Uzun, Wenbao Yu, Qin Zhu, Regina M. Myers, Stephan A. Grupp, David M. Barrett, Kai Tan, 2021, Cancer Discovery on p. 2186-2199

Identifying noncoding risk variants using disease-relevant gene regulatory networks

Long Gao, Yasin Uzun, Peng Gao, Bing He, Xiaoke Ma, Jiahui Wang, Shizhong Han, Kai Tan, 2018, Nature Communications

Yasin Uzun

Assistant Professor of Pediatrics

Research Summary

Huck Affiliations

Links

Publication Tags

Most Recent Publications

ER stress elicits non-canonical CASP8 (caspase 8) activation on autophagosomal membranes to induce apoptosis

Integrating Single-Cell Methylome and Transcriptome Data with MAPLE

Targeting drug-resistant acute myeloid leukemia (AML) cells using novel casein kinase II (CK2) inhibitor

Isolation of Epithelial and Stromal Cells from Colon Tissues in Homeostasis and Under Inflammatory Conditions

Ncrna-a3 Epigenetically Regulates TAL1 and Its Target Genes to Drive Erythroid Differentiation

Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis

Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell–like blasts in KMT2A-rearranged leukemia

MITI minimum information guidelines for highly multiplexed tissue images

Epigenetic state determines inflammatory sensing in neuroblastoma

Defining therapeutic vulnerabilities of persister cells in high-risk neuroblastoma

Most-Cited Papers

The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

Developmental trajectory of prehematopoietic stem cell formation from endothelium

Integrative bulk and single-cell profiling of premanufacture t-cell populations reveals factors mediating long-term persistence of car t-cell therapy

Identifying noncoding risk variants using disease-relevant gene regulatory networks

Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell–like blasts in KMT2A-rearranged leukemia

Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells

Risk variants disrupting enhancers of T<sub>H</sub>1 and T<sub>REG</sub> cells in type 1 diabetes

MITI minimum information guidelines for highly multiplexed tissue images

ScATAC-pro: A comprehensive workbench for single-cell chromatin accessibility sequencing data

Epigenetic state determines inflammatory sensing in neuroblastoma