Xuemei Huang

Professor of Neurology

Xuemei Huang

Most Recent Publications

Neuropathological findings and in vivo imaging correlates of the red nucleus compared to those of the substantia nigra pars compacta in parkinsonisms

Melinda L. Johnson, Mechelle M. Lewis, Ernest W. Wang, Leslie C. Jellen, Guangwei Du, Sol De Jesus, Lan Kong, Cunfeng Pu, Xuemei Huang, 2024, Parkinsonism and Related Disorders

High-Yield α-Synuclein Purification and Ionic Strength Modification Pivotal to Seed Amplification Assay Performance and Reproducibility

Chelva Janarthanam, Griffin Clabaugh, Zerui Wang, Bradley R. Melvin, Ileia Scheibe, Huajun Jin, Vellareddy Anantharam, Ramona J.B. Urbauer, Jeffrey L. Urbauer, Jiyan Ma, Arthi Kanthasamy, Xuemei Huang, Vincenzo Donadio, Wenquan Zou, Anumantha G. Kanthasamy, 2024, International Journal of Molecular Sciences

Design and methods of the mobile assessment of cognition, environment, and sleep (MACES) feasibility study in newly diagnosed breast cancer patients

R Derbes, Jonathan Hakun, D Elbich, L Master, Sheri Berenbaum, X Huang, Orfeu M. Buxton, Anne-Marie Chang, Cristina I. Truica, K Sturgeon, 2024, Scientific Reports on p. 8338

Prevalence of Late-Stage Parkinson's Disease in the US Healthcare System: Insights from TriNetX

Sol De Jesus, Annika Daya, Liba Blumberger, Mechelle Lewis, Douglas Leslie, Samer D. Tabbal, Rachel Dokholyan, Amanda Snyder, Richard B. Mailman, Xuemei Huang, 2024, Movement Disorders

Air Pollutants and Risk of Parkinson’s Disease among Women in the Sister Study

Zichun Cao, Yaqun Yuan, Alexandra J. White, Chenxi Li, Zhehui Luo, Aimee A. D’aloisio, Xuemei Huang, Joel D. Kaufman, Dale P. Sandler, Honglei Chen, 2024, Environmental Health Perspectives

Resting-state global brain activity affects early β-amyloid accumulation in default mode network

Feng Han, Xufu Liu, Richard B. Mailman, Xuemei Huang, Xiao Liu, 2023, Nature Communications

Seeding and amplifying parkinsonism research

Xuemei Huang, Anumantha G. Kanthasamy, 2023, Parkinsonism and Related Disorders

Author Correction: Safety and efficacy of anti-tau monoclonal antibody gosuranemab in progressive supranuclear palsy: a phase 2, randomized, placebo-controlled trial (Nature Medicine, (2021), 27, 8, (1451-1457), 10.1038/s41591-021-01455-x)

Tien Dam, Adam L. Boxer, Lawrence I. Golbe, Günter U. Höglinger, Huw R. Morris, Irene Litvan, Anthony E. Lang, Jean Christophe Corvol, Ikuko Aiba, Michael Grundman, Lili Yang, Beth Tidemann-Miller, Joseph Kupferman, Kristine Harper, Kubra Kamisoglu, Michael J. Wald, Danielle L. Graham, Liz Gedney, John O’Gorman, Samantha Budd Haeberlein, Ikuko Aiba, Angelo Antonini, Diana Apetauerova, Jean Philippe Azulay, Ernest Balaguer Martinez, Jee Bang, Paolo Barone, Matthew Barrett, Danny Bega, Daniela Berg, Koldo Berganzo Corrales, Yvette Bordelon, Adam L. Boxer, Moritz Brandt, Norbert Brueggemann, Giovanni Castelnovo, Roberto Ceravolo, Rosalind Chuang, Sun Ju Chung, Alistair Church, Jean Christophe Corvol, Paola Cudia, Marian Dale, Luc Defebvre, Sophie Drapier, Erika D. Driver-Dunckley, Georg Ebersbach, Karla M. Eggert, Aaron Ellenbogen, Xuemei Huang, 2023, Nature Medicine on p. 2955-2956

Polygenic risk score for Parkinson's disease and olfaction among middle-aged to older women

Zichun Cao, Dena G. Hernandez, Chenxi Li, Joos Berghausen, Zhehui Luo, Hirotaka Iwaki, Aimee A. D'Aloisio, Xuemei Huang, Jayant M. Pinto, Dale P. Sandler, Andrew B. Singleton, Honglei Chen, 2023, Parkinsonism and Related Disorders

Multi-muscle synergies in preparation for gait initiation in Parkinson's disease

Ali Falaki, Cristian Cuadra, Mechelle M. Lewis, Janina M. Prado-Rico, Janina Prado Rico, Xuemei Huang, Mark L. Latash, 2023, Electroencephalography and Clinical Neurophysiology - Electromyography and Motor Control on p. 12-24

Most-Cited Papers

Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy

Suzanne Lesage, Valérie Drouet, Elisa Majounie, Vincent Deramecourt, Maxime Jacoupy, Aude Nicolas, Florence Cormier-Dequaire, Sidi Mohamed Hassoun, Claire Pujol, Sorana Ciura, Zoi Erpapazoglou, Tatiana Usenko, Claude Alain Maurage, Mourad Sahbatou, Stefan Liebau, Jinhui Ding, Basar Bilgic, Murat Emre, Nihan Erginel-Unaltuna, Gamze Guven, François Tison, Christine Tranchant, Marie Vidailhet, Jean Christophe Corvol, Paul Krack, Anne Louise Leutenegger, Michael A. Nalls, Dena G. Hernandez, Peter Heutink, J. Raphael Gibbs, John Hardy, Nicholas W. Wood, Thomas Gasser, Alexandra Durr, Jean François Deleuze, Meriem Tazir, Alain Destée, Ebba Lohmann, Edor Kabashi, Andrew Singleton, Olga Corti, Alexis Brice, François Tison, Marie Vidailhet, Jean Christophe Corvol, Yves Agid, Mathieu Anheim, Anne Marie Bonnet, Michel Borg, Emmanuel Broussolle, Philippe Damier, Alain Destée, Alexandra Dürr, Franck Durif, Paul Krack, Stephan Klebe, Ebba Lohmann, Maria Martinez, Pierre Pollak, Olivier Rascol, Christine Tranchant, Marc Vérin, François Viallet, Suzanne Lesage, Elisa Majounie, François Tison, Marie Vidailhet, Jean Christophe Corvol, Michael A. Nalls, Dena G. Hernandez, Alexandra Dürr, Sampath Arepalli, Roger A. Barker, Yoav Ben-Shlomo, Daniela Berg, Francesco Bettella, Kailash Bhatia, Rob M.A. de Bie, Alessandro Biffi, Bastiaan R. Bloem, Zoltan Bochdanovits, Michael Bonin, Jose M. Bras, Kathrin Brockmann, Janet Brooks, David J. Burn, Gavin Charlesworth, Honglei Chen, Patrick F. Chinnery, Sean Chong, Carl E. Clarke, Mark R. Cookson, Carl Counsell, Philippe Damier, Jean François Dartigues, Panos Deloukas, Günther Deuschl, David T. Dexter, Karin D. van Dijk, Allissa Dillman, Jing Dong, Frank Durif, Sarah Edkins, Valentina Escott-Price, Jonathan R. Evans, Thomas Foltynie, Jianjun Gao, Michelle Gardner, Alison Goate, Emma Gray, Rita Guerreiro, Clare Harris, Jacobus J. van Hilten, Albert Hofman, Albert Hollenbeck, Peter Holmans, Janice Holton, Michèle Hu, Xuemei Huang, Heiko Huber, Gavin Hudson, Sarah E. Hunt, Johanna Huttenlocher, Thomas Illig, Pálmi V. Jónsson, Laura L. Kilarski, Iris E. Jansen, Jean Charles Lambert, Cordelia Langford, Andrew Lees, Peter Lichtner, Patricia Limousin, Grisel Lopez, Delia Lorenz, Steven Lubbe, Codrin Lungu, María Martinez, Walter Mätzler, Alisdair McNeill, Catriona Moorby, Matthew Moore, Karen E. Morrison, Ese Mudanohwo, Sean S. O’sullivan, Michael J. Owen, Justin Pearson, Joel S. Perlmutter, Hjörvar Pétursson, Vincent Plagnol, Pierre Pollak, Bart Post, Simon Potter, Bernard Ravina, Tamas Revesz, Olaf Riess, Fernando Rivadeneira, Patrizia Rizzu, Mina Ryten, Mohamad Saad, Javier Simón-Sánchez, Stephen Sawcer, Anthony Schapira, Hans Scheffer, Claudia Schulte, Manu Sharma, Karen Shaw, Una Marie Sheerin, Ira Shoulson, Joshua Shulman, Ellen Sidransky, Chris C.A. Spencer, Hreinn Stefánsson, Kári Stefánsson, Joanna D. Stockton, Amy Strange, Kevin Talbot, Carlie M. Tanner, Avazeh Tashakkori-Ghanbaria, Daniah Trabzuni, Bryan J. Traynor, André G. Uitterlinden, Daan Velseboer, Robert Walker, Bart van de Warrenburg, Mirdhu Wickremaratchi, Caroline H. Williams-Gray, Sophie Winder-Rhodes, Isabel Wurster, Nigel Williams, Huw R. Morris, Peter Heutink, Thomas Gasser, Andrew B. Singleton, Alexis Brice, 2016, American Journal of Human Genetics on p. 500-513

Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease

Laurie A. Robak, Iris E. Jansen, Jeroen van Rooij, André G. Uitterlinden, Robert Kraaij, Joseph Jankovic, Peter Heutink, Joshua M. Shulman, Mike A. Nalls, Vincent Plagnol, Dena G. Hernandez, Manu Sharma, Una Marie Sheerin, Mohamad Saad, Javier Simón-Sánchez, Claudia Schulte, Suzanne Lesage, Sigurlaug Sveinbjörnsdóttir, Sampath Arepalli, Roger Barker, Yoav Ben, Henk W. Berendse, Daniela Berg, Kailash Bhatia, Rob M.A. de Bie, Alessandro Biffi, Bas Bloem, Zoltan Bochdanovits, Michael Bonin, Jose M. Bras, Kathrin Brockmann, Janet Brooks, David J. Burn, Elisa Majounie, Gavin Charlesworth, Codrin Lungu, Honglei Chen, Patrick F. Chinnery, Sean Chong, Carl E. Clarke, Mark R. Cookson, J. Mark Cooper, Jean Christophe Corvol, Carl Counsell, Philippe Damier, Jean François Dartigues, Panos Deloukas, Günther Deuschl, David T. Dexter, Karin D. van Dijk, Allissa Dillman, Frank Durif, Alexandra Dürr, Sarah Edkins, Jonathan R. Evans, Thomas Foltynie, Jing Dong, Michelle Gardner, J. Raphael Gibbs, Alison Goate, Emma Gray, Rita Guerreiro, Clare Harris, Jacobus J. van Hilten, Albert Hofman, Albert Hollenbeck, Janice Holton, Michele Hu, Xuemei Huang, Isabel Wurster, Walter Mätzler, Gavin Hudson, Sarah E. Hunt, Johanna Huttenlocher, Thomas Illig, Pálmi V. Jónsson, Jean Charles Lambert, Cordelia Langford, Andrew Lees, Peter Lichtner, Patricia Limousin, Grisel Lopez, Delia Lorenz, Codrin Lungu, Alisdair McNeill, Catriona Moorby, Matthew Moore, Huw R. Morris, Karen E. Morrison, Valentina Escott-Price, Ese Mudanohwo, Sean S. O’sullivan, Justin Pearson, Joel S. Perlmutter, Hjörvar Pétursson, Pierre Pollak, Bart Post, Simon Potter, Bernard Ravina, Tamas Revesz, Olaf Riess, Fernando Rivadeneira, Patrizia Rizzu, Mina Ryten, Stephen Sawcer, Anthony Schapira, Hans Scheffer, Karen Shaw, Ira Shoulson, Joshua Shulman, Ellen Sidransky, Colin Smith, Chris C.A. Spencer, Hreinn Stefánsson, Francesco Bettella, Joanna D. Stockton, Amy Strange, Kevin Talbot, Carlie M. Tanner, Avazeh Tashakkori-Ghanbaria, François Tison, Daniah Trabzuni, Bryan J. Traynor, André G. Uitterlinden, Daan Velseboer, Marie Vidailhet, Robert Walker, Bart van de Warrenburg, Mirdhu Wickremaratchi, Nigel Williams, Caroline H. Williams-Gray, Sophie Winder-Rhodes, Kári Stefánsson, Maria Martinez, Nicholas W. Wood, John Hardy, Peter Heutink, Alexis Brice, Thomas Gasser, Andrew B. Singleton, 2017, Brain on p. 3191-3203

Genome-wide pleiotropy between Parkinson disease and autoimmune diseases

Aree Witoelar, Iris E. Jansen, Yunpeng Wang, Rahul S. Desikan, J. Raphael Gibbs, Cornelis Blauwendraat, Wesley K. Thompson, Dena G. Hernandez, Srdjan Djurovic, Andrew J. Schork, Francesco Bettella, David Ellinghaus, Andre Franke, Benedicte A. Lie, Linda K. McEvoy, Tom H. Karlsen, Suzanne Lesage, Huw R. Morris, Alexis Brice, Nicholas W. Wood, Peter Heutink, John Hardy, Andrew B. Singleton, Anders M. Dale, Thomas Gasser, Ole A. Andreassen, Manu Sharma, Mike A. Nalls, Vincent Plagnol, Una Marie Sheerin, Mohamad Saad, Javier Simon-Sanchez, Claudia Schulte, Sigurlaug Sveinbjornsdottir, Sampath Arepalli, Roger Barker, Yoav Ben-Shlomo, Henk W. Berendse, Daniela Berg, Kailash Bhatia, Rob M.A. De Bie, Alessandro Biffi, Bas Bloem, Zoltan Bochdanovits, Michael Bonin, Jose M. Bras, Kathrin Brockmann, Janet Brooks, David J. Burn, Xuemei Huang, 2017, JAMA Neurology on p. 780-792

Clinical quantitative susceptibility mapping (QSM): Biometal imaging and its emerging roles in patient care

Yi Wang, Pascal Spincemaille, Zhe Liu, Alexey Dimov, Kofi Deh, Jianqi Li, Yan Zhang, Yihao Yao, Kelly M. Gillen, Alan H. Wilman, Ajay Gupta, Apostolos John Tsiouris, Ilhami Kovanlikaya, Gloria Chia Yi Chiang, Jonathan W. Weinsaft, Lawrence Tanenbaum, Weiwei Chen, Wenzhen Zhu, Shixin Chang, Min Lou, Brian H. Kopell, Michael G. Kaplitt, David Devos, Toshinori Hirai, Xuemei Huang, Yukunori Korogi, Alexander Shtilbans, Geon Ho Jahng, Daniel Pelletier, Susan A. Gauthier, David Pitt, Ashley I. Bush, Gary M. Brittenham, Martin R. Prince, 2017, Journal of Magnetic Resonance Imaging on p. 951-971

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

M. C. Cornelis, E. M. Byrne, T. Esko, M. A. Nalls, A. Ganna, N. Paynter, K. L. Monda, N. Amin, K. Fischer, F. Renstrom, J. S. Ngwa, V. Huikari, A. Cavadino, I. M. Nolte, A. Teumer, K. Yu, P. Marques-Vidal, R. Rawal, A. Manichaikul, M. K. Wojczynski, J. M. Vink, J. H. Zhao, G. Burlutsky, J. Lahti, V. Mikkilä, R. N. Lemaitre, J. Eriksson, S. K. Musani, T. Tanaka, F. Geller, J. Luan, J. Hui, R. Mägi, M. Dimitriou, M. E. Garcia, W. K. Ho, M. J. Wright, L. M. Rose, P. K.E. Magnusson, N. L. Pedersen, D. Couper, B. A. Oostra, A. Hofman, M. A. Ikram, H. W. Tiemeier, A. G. Uitterlinden, F. J.A. van Rooij, I. Barroso, I. Johansson, L. Xue, M. Kaakinen, L. Milani, C. Power, H. Snieder, R. P. Stolk, S. E. Baumeister, R. Biffar, F. Gu, F. Bastardot, Z. Kutalik, D. R. Jacobs, N. G. Forouhi, E. Mihailov, L. Lind, C. Lindgren, K. Michaëlsson, A. Morris, M. Jensen, K. T. Khaw, R. N. Luben, J. J. Wang, S. Männistö, M. M. Perälä, M. Kähönen, T. Lehtimäki, J. Viikari, D. Mozaffarian, K. Mukamal, B. M. Psaty, A. Döring, A. C. Heath, G. W. Montgomery, N. Dahmen, T. Carithers, K. L. Tucker, L. Ferrucci, H. A. Boyd, M. Melbye, J. L. Treur, D. Mellström, J. J. Hottenga, I. Prokopenko, A. Tönjes, P. Deloukas, S. Kanoni, M. Lorentzon, D. K. Houston, Y. Liu, J. Danesh, A. Rasheed, M. A. Mason, A. B. Zonderman, L. Franke, B. S. Kristal, J. Karjalainen, D. R. Reed, H. J. Westra, M. K. Evans, D. Saleheen, T. B. Harris, G. Dedoussis, G. Curhan, M. Stumvoll, J. Beilby, L. R. Pasquale, B. Feenstra, S. Bandinelli, J. M. Ordovas, A. T. Chan, U. Peters, C. Ohlsson, C. Gieger, N. G. Martin, M. Waldenberger, D. S. Siscovick, O. Raitakari, J. G. Eriksson, P. Mitchell, D. J. Hunter, P. Kraft, E. B. Rimm, D. I. Boomsma, I. B. Borecki, R. J.F. Loos, N. J. Wareham, P. Vollenweider, N. Caporaso, H. J. Grabe, M. L. Neuhouser, B. H.R. Wolffenbuttel, F. B. Hu, E. Hyppönen, M. R. Järvelin, L. A. Cupples, P. W. Franks, P. M. Ridker, C. M. van Duijn, G. Heiss, A. Metspalu, K. E. North, E. Ingelsson, J. A. Nettleton, R. M. van Dam, D. I. Chasman, Michael A. Nalls, Vincent Plagnol, Dena G. Hernandez, Manu Sharma, Una Marie Sheerin, Mohamad Saad, Javier Simón-Sánchez, Claudia Schulte, Suzanne Lesage, Sigurlaug Sveinbjörnsdóttir, Sampath Arepalli, Roger Barker, Yoav Ben-Shlomo, Henk W. Berendse, Daniela Berg, Kailash Bhatia, Rob M.A. de Bie, Alessandro Biffi, Bas Bloem, Zoltan Bochdanovits, Michael Bonin, Jose M. Bras, Kathrin Brockmann, Janet Brooks, David J. Burn, Gavin Charlesworth, Honglei Chen, Patrick F. Chinnery, Sean Chong, Carl E. Clarke, Mark R. Cookson, J. Mark Cooper, Jean Christophe Corvol, Carl Counsell, Philippe Damier, Jean François Dartigues, Panos Deloukas, Günther Deuschl, David T. Dexter, Karin D.van Dijk, Allissa Dillman, Frank Durif, Alexandra Dürr, Sarah Edkins, Jonathan R. Evans, Thomas Foltynie, Jing Dong, Michelle Gardner, J. Raphael Gibbs, Alison Goate, Emma Gray, Rita Guerreiro, Clare Harris, Jacobus J.van Hilten, Albert Hollenbeck, Janice Holton, Michele Hu, Xuemei Huang, Isabel Wurster, Walter Mätzler, Gavin Hudson, Sarah E. Hunt, Johanna Huttenlocher, Thomas Illig, Pálmi V. Jónsson, Jean Charles Lambert, Cordelia Langford, Andrew Lees, Peter Lichtner, Patricia Limousin, Grisel Lopez, Delia Lorenz, Alisdair McNeill, Catriona Moorby, Matthew Moore, Huw R. Morris, Karen E. Morrison, Ese Mudanohwo, Sean S. O’sullivan, Justin Pearson, Joel S. Perlmutter, Hjörvar Pétursson, Pierre Pollak, Bart Post, Simon Potter, Bernard Ravina, Tamas Revesz, Olaf Riess, Fernando Rivadeneira, Patrizia Rizzu, Mina Ryten, Stephen Sawcer, Anthony Schapira, Hans Scheffer, Karen Shaw, Ira Shoulson, Ellen Sidransky, Colin Smith, Chris C.A. Spencer, Hreinn Stefánsson, Francesco Bettella, Joanna D. Stockton, Amy Strange, Kevin Talbot, Carlie M. Tanner, Avazeh Tashakkori-Ghanbaria, François Tison, Daniah Trabzuni, Bryan J. Traynor, Daan Velseboer, Marie Vidailhet, Robert Walker, Bart van de Warrenburg, Mirdhu Wickremaratchi, Nigel Williams, Caroline H. Williams-Gray, Sophie Winder-Rhodes, Kári Stefánsson, Maria Martinez, Nicholas W. Wood, John Hardy, Peter Heutink, Alexis Brice, Thomas Gasser, Andrew B. Singleton, Andrew Singleton, Mark Cookson, Reta Lila, Dena Hernandez, Reta Lila, Allissa Dillman, Michael Nalls, Alan Zonderman, Sampath Arepalli, Robert Johnson, Dan Longo, Richard O'brien, Bryan Traynor, Juan Troncoso, Marcel van der Brug, Ronald Zielke, Michael Weale, Mina Ryten, Adaikalavan Ramasamy, Reta Lila, Daniah Trabzuni, Robert Walker, 2015, Molecular Psychiatry on p. 647-656

Meta-analyses on prevalence of selected Parkinson's nonmotor symptoms before and after diagnosis

Honglei Chen, Edward J. Zhao, Wen Zhang, Yi Lu, Rui Liu, Xuemei Huang, Anna J. Ciesielski-Jones, Michele A. Justice, Deborah S. Cousins, Shyamal Peddada, 2015, Translational Neurodegeneration

Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein

Dilshan S. Harischandra, Dharmin Rokad, Matthew L. Neal, Shivani Ghaisas, Sireesha Manne, Souvarish Sarkar, Nikhil Panicker, Gary Zenitsky, Huajun Jin, Mechelle Lewis, Xuemei Huang, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy, 2019, Science's STKE : signal transduction knowledge environment

Quantitative susceptibility mapping of the midbrain in Parkinson's disease

Guangwei Du, T Liu, Mechelle M. Lewis, Lan Kong, Y Wang, James Connor, Richard B. Mailman, Xuemei Huang, 2016, Movement Disorders on p. 317-324

Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells

S Sarkar, D Rokad, E Malovic, J Luo, D Harischandra, H Jin, V Anantharam, Xuemei Huang, Mechelle Lewis, A Kanthasamy, A Kanthasamy, 2019, Science's STKE : signal transduction knowledge environment

Projection of the prevalence of Parkinson's disease in the coming decades: Revisited

Alexander Rossi, Kristin Berger, Honglei Chen, Douglas Leslie, Richard Mailman, Xuemei Huang, 2018, Movement Disorders on p. 156-159