Xiaojun (Lance) Lian
Associate Professor of Biomedical Engineering
Human Stem Cell Engineering; Genome Editing via CRISPR-Cas9; Epigenome Editing and Epigenetics.
Huck Graduate Students
- Molecular, Cellular, and Integrative Biosciences
- Regenerative Engineering and Translational Ecosystem Forum
These publication tags are generated from the output of this researcher. Click any tag below to view other Huck researchers working on the same topic.Pluripotent Stem Cells Stem Cells Catenins Glucose Cardiac Myocytes Mechanics Clustered Regularly Interspaced Short Palindromic Repeats Endothelial Cells Drug Beta Catenin Application Molecules Proteins Graphene Substrates Flow Nanopores Gene Editing Lasers Cytometry Messenger Rna Dna Genomics Rna Hydrogels
Most Recent Publications
CAR-neutrophil mediated delivery of tumor-microenvironment responsive nanodrugs for glioblastoma chemo-immunotherapy
Yun Chang, Xuechao Cai, Ramizah Syahirah, Yuxing Yao, Yang Xu, Gyuhyung Jin, Vijesh J. Bhute, Sandra Torregrosa-Allen, Bennett D. Elzey, You Yeon Won, Qing Deng, Xiaojun Lance Lian, Xiaoguang Wang, Omolola Eniola-Adefeso, Xiaoping Bao, 2023, Nature Communications
Engineered human pluripotent stem cell-derived natural killer cells with PD-L1 responsive immunological memory for enhanced immunotherapeutic efficacy
Yun Chang, Gyuhyung Jin, Weichuan Luo, Qian Luo, Juhyung Jung, Sydney N. Hummel, Sandra Torregrosa-Allen, Bennett D. Elzey, Philip S. Low, Xiaojun Lance Lian, Xiaoping Bao, 2023, Bioactive Materials on p. 168-180
Engineered Artificial Human Neutrophils Exhibit Mature Functional Performance
Yun Chang, Sydney N. Hummel, Monique N. Watson, Gyuhyung Jin, Xiaojun Lance Lian, Xiaoping Bao, 2023, ACS Synthetic Biology on p. 2262-2270
Kai Wang, Xujie Liu, Xiaojun Lance Lian, Xiaoping Bao, Kailong Li, 2023, Frontiers in Bioengineering and Biotechnology
Alessandro R. Howells, Phoebe J. Welch, John Kim, Craig R. Forest, Chengzhi Shi, Xiaojun Lance Lian, 2023, Bioengineering and Translational Medicine
J Jung, Y Chang, G Jin, Q Deng, Xiaojun Lian, X Bao, 2022, STAR Protocols on p. 101953
Wnt signaling directs human pluripotent stem cells into vascularized cardiac organoids with chamber-like structures
Po Yu Liang, Yun Chang, Gyuhyung Jin, Xiaojun Lian, Xiaoping Bao, 2022, Frontiers in Bioengineering and Biotechnology
O Wang, L Han, H Lin, M Tian, S Zhang, B Duan, S Chung, C Zhang, Xiaojun Lian, Y Wang, Yuguo Lei, 2022, Bioactive Materials on p. 518-534
T Haideri, A Howells, Y Jiang, J Yang, X Bao, Xiaojun Lian, 2022, Cell Reports Methods on p. 100290
Yuqian Jiang, Rachel Catherine Hoenisch, Yun Chang, Xiaoping Bao, Craig E. Cameron, Xiaojun Lance Lian, 2022, Bioactive Materials on p. 313-320
Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions
Xiaojun Lian, Jianhua Zhang, Samira M. Azarin, Kexian Zhu, Laurie B. Hazeltine, Xiaoping Bao, Cheston Hsiao, Timothy J. Kamp, Sean P. Palecek, 2013, Nature Protocols on p. 162-175
Efficient differentiation of human pluripotent stem cells to endothelial progenitors via small-molecule activation of WNT signaling
Xiaojun Lian, Xiaoping Bao, Abraham Al-Ahmad, Jialu Liu, Yue Wu, Wentao Dong, Kaitlin K. Dunn, Eric V. Shusta, Sean P. Palecek, 2014, Stem Cell Reports on p. 804-816
Xiaojun Lian, Xiaoping Bao, Misha Zilberter, Mattias Westman, André Fisahn, Cheston Hsiao, Laurie B. Hazeltine, Kaitlin K. Dunn, Timothy J. Kamp, Sean P. Palecek, 2015, Nature Methods on p. 595-596
Jian Yang, Jia Zhu, Shangbin Liu, Zhihui Hu, Xianzhe Zhang, Ning Yi, Kairui Tang, Michael Dexheimer, Xiaojun Lian, Q Wang, J Yang, Jennifer Gray, Huanyu Cheng, 2021, Biosensors and Bioelectronics on p. 113606
Sequence-Specific Recognition of HIV-1 DNA with Solid-State CRISPR-Cas12a-Assisted Nanopores (SCAN)
Reza Nouri, Yuqian Jiang, Xiaojun Lance Lian, Weihua Guan, 2020, ACS Sensors on p. 1273-1280
Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions
Xiaoping Bao, Xiaojun Lian, Timothy A. Hacker, Eric G. Schmuck, Tongcheng Qian, Vijesh J. Bhute, Tianxiao Han, Mengxuan Shi, Lauren Drowley, Alleyn T. Plowright, Qing Dong Wang, Marie Jose Goumans, Sean P. Palecek, 2017, Nature Biomedical Engineering
Chemically-defined albumin-free differentiation of human pluripotent stem cells to endothelial progenitor cells
Xiaoping Bao, Xiaojun Lian, Kaitlin K. Dunn, Mengxuan Shi, Tianxiao Han, Tongcheng Qian, Vijesh J. Bhute, Scott G. Canfield, Sean P. Palecek, 2015, Stem Cell Research on p. 122-129
Temporal impact of substrate mechanics on differentiation of human embryonic stem cells to cardiomyocytes
Laurie B. Hazeltine, Mehmet G. Badur, Xiaojun Lian, Amritava Das, Wenqing Han, Sean P. Palecek, 2014, Acta Biomaterialia on p. 604-612
Insulin inhibits cardiac mesoderm, not mesendoderm, formation during cardiac differentiation of human pluripotent stem cells and modulation of canonical wnt signaling can rescue this inhibition
Xiaojun Lian, Jianhua Zhang, Kexian Zhu, Timothy J. Kamp, Sean P. Palecek, 2013, Stem Cells on p. 447-457
Cheston Hsiao, Michael Lampe, Songkhun Nillasithanukroh, Wenqing Han, Xiaojun Lian, Sean P. Palecek, 2016, Biotechnology Journal on p. 662-675
News Articles Featuring Xiaojun (Lance) Lian
Sep 18, 2023
Novel approach to engineered cells may enable molecular medical imaging
A tiny molecular structure that looks like a bubble may be able to significantly improve medical imaging, according to a Penn State research team led by Lance Lian.
Jun 20, 2023
Penn State researchers develop digital test to directly measure HIV viral load
A milliliter of blood contains about 15 individual drops. For a person with human immunodeficiency virus (HIV), each drop of blood could contain anywhere from fewer than 20 copies of the virus to more than 500,000 copies.
Dec 19, 2022
New 'Life From All Angles' video highlights Lance Lian’s stem cell research
The latest episode of "Life From All Angles," a YouTube series from the Huck Institutes of the Life Sciences, features Associate Professor of Biomedical Engineering Xiaojun "Lance" Lian and his efforts to produce new cardiomyocytes to advance the effectiveness of stem cell differentiation.
Sep 27, 2022
Game-changing stem cell engineer Lance Lian featured on Symbiotic podcast
Xiaojun “Lance” Lian, associate professor of biomedical engineering, is set to be the Symbiotic podcast’s final guest for 2022 when he appears at noon on Wednesday, Sept. 28 on the Huck Institutes of the Life Sciences’ livestream page.
Sep 09, 2022
Penn State-led team develops more efficient system for delivering CRISPR to stem cells
Modified mRNA (modRNA)-based CRISPR systems improve on the transfection and knockout efficiency of plasmid-based systems in human pluripotent stem cells (hPSCs), a Penn State-led team of interdisciplinary researchers has found.
Sep 07, 2022
New approach more than doubles stem cell editing efficiency, researchers report
A Penn State-led team of interdisciplinary researchers has developed techniques to improve the efficiency of CRISPR-Cas9, the genome editing technique that earned the Nobel Prize in 2020.
Mar 07, 2022
Studying diseases with better delivery of gene-editing tools
Using gene-editing tools with stem cells can be challenging because their delivery into cells can be inefficient, time-consuming, or expensive. A Penn State-led team of interdisciplinary researchers has developed a method that improves the lifespan and efficiency of CRISPR gene-editing tools after delivery.