Xiaojun (Lance) Lian

Associate Professor of Biomedical Engineering

Xiaojun (Lance) Lian

Research Summary

Human Stem Cell Engineering; Genome Editing via CRISPR-Cas9; Epigenome Editing and Epigenetics.

Huck Graduate Students

Huck Affiliations


Publication Tags

These publication tags are generated from the output of this researcher. Click any tag below to view other Huck researchers working on the same topic.

Pluripotent Stem Cells Stem Cells Catenins Glucose Cardiac Myocytes Mechanics Clustered Regularly Interspaced Short Palindromic Repeats Endothelial Cells Drug Beta Catenin Application Molecules Proteins Graphene Substrates Flow Nanopores Gene Editing Lasers Cytometry Messenger Rna Dna Genomics Rna Hydrogels

Most Recent Publications

Yun Chang, Xuechao Cai, Ramizah Syahirah, Yuxing Yao, Yang Xu, Gyuhyung Jin, Vijesh J. Bhute, Sandra Torregrosa-Allen, Bennett D. Elzey, You Yeon Won, Qing Deng, Xiaojun Lance Lian, Xiaoguang Wang, Omolola Eniola-Adefeso, Xiaoping Bao, 2023, Nature Communications

Yun Chang, Gyuhyung Jin, Weichuan Luo, Qian Luo, Juhyung Jung, Sydney N. Hummel, Sandra Torregrosa-Allen, Bennett D. Elzey, Philip S. Low, Xiaojun Lance Lian, Xiaoping Bao, 2023, Bioactive Materials on p. 168-180

Engineered Artificial Human Neutrophils Exhibit Mature Functional Performance

Yun Chang, Sydney N. Hummel, Monique N. Watson, Gyuhyung Jin, Xiaojun Lance Lian, Xiaoping Bao, 2023, ACS Synthetic Biology on p. 2262-2270

Kai Wang, Xujie Liu, Xiaojun Lance Lian, Xiaoping Bao, Kailong Li, 2023, Frontiers in Bioengineering and Biotechnology

Alessandro R. Howells, Phoebe J. Welch, John Kim, Craig R. Forest, Chengzhi Shi, Xiaojun Lance Lian, 2023, Bioengineering and Translational Medicine

J Jung, Y Chang, G Jin, Q Deng, Xiaojun Lian, X Bao, 2022, STAR Protocols on p. 101953

Po Yu Liang, Yun Chang, Gyuhyung Jin, Xiaojun Lian, Xiaoping Bao, 2022, Frontiers in Bioengineering and Biotechnology

O Wang, L Han, H Lin, M Tian, S Zhang, B Duan, S Chung, C Zhang, Xiaojun Lian, Y Wang, Yuguo Lei, 2022, Bioactive Materials on p. 518-534

T Haideri, A Howells, Y Jiang, J Yang, X Bao, Xiaojun Lian, 2022, Cell Reports Methods on p. 100290

Yuqian Jiang, Rachel Catherine Hoenisch, Yun Chang, Xiaoping Bao, Craig E. Cameron, Xiaojun Lance Lian, 2022, Bioactive Materials on p. 313-320

Most-Cited Papers

Xiaojun Lian, Jianhua Zhang, Samira M. Azarin, Kexian Zhu, Laurie B. Hazeltine, Xiaoping Bao, Cheston Hsiao, Timothy J. Kamp, Sean P. Palecek, 2013, Nature Protocols on p. 162-175

Xiaojun Lian, Xiaoping Bao, Abraham Al-Ahmad, Jialu Liu, Yue Wu, Wentao Dong, Kaitlin K. Dunn, Eric V. Shusta, Sean P. Palecek, 2014, Stem Cell Reports on p. 804-816

Xiaojun Lian, Xiaoping Bao, Misha Zilberter, Mattias Westman, André Fisahn, Cheston Hsiao, Laurie B. Hazeltine, Kaitlin K. Dunn, Timothy J. Kamp, Sean P. Palecek, 2015, Nature Methods on p. 595-596

Jian Yang, Jia Zhu, Shangbin Liu, Zhihui Hu, Xianzhe Zhang, Ning Yi, Kairui Tang, Michael Dexheimer, Xiaojun Lian, Q Wang, J Yang, Jennifer Gray, Huanyu Cheng, 2021, Biosensors and Bioelectronics on p. 113606

Sequence-Specific Recognition of HIV-1 DNA with Solid-State CRISPR-Cas12a-Assisted Nanopores (SCAN)

Reza Nouri, Yuqian Jiang, Xiaojun Lance Lian, Weihua Guan, 2020, ACS Sensors on p. 1273-1280

Xiaoping Bao, Xiaojun Lian, Timothy A. Hacker, Eric G. Schmuck, Tongcheng Qian, Vijesh J. Bhute, Tianxiao Han, Mengxuan Shi, Lauren Drowley, Alleyn T. Plowright, Qing Dong Wang, Marie Jose Goumans, Sean P. Palecek, 2017, Nature Biomedical Engineering

Xiaoping Bao, Xiaojun Lian, Kaitlin K. Dunn, Mengxuan Shi, Tianxiao Han, Tongcheng Qian, Vijesh J. Bhute, Scott G. Canfield, Sean P. Palecek, 2015, Stem Cell Research on p. 122-129

Laurie B. Hazeltine, Mehmet G. Badur, Xiaojun Lian, Amritava Das, Wenqing Han, Sean P. Palecek, 2014, Acta Biomaterialia on p. 604-612

Cheston Hsiao, Michael Lampe, Songkhun Nillasithanukroh, Wenqing Han, Xiaojun Lian, Sean P. Palecek, 2016, Biotechnology Journal on p. 662-675

News Articles Featuring Xiaojun (Lance) Lian

Novel approach to engineered cells may enable molecular medical imaging

A tiny molecular structure that looks like a bubble may be able to significantly improve medical imaging, according to a Penn State research team led by Lance Lian.

Penn State researchers develop digital test to directly measure HIV viral load

A milliliter of blood contains about 15 individual drops. For a person with human immunodeficiency virus (HIV), each drop of blood could contain anywhere from fewer than 20 copies of the virus to more than 500,000 copies.

New 'Life From All Angles' video highlights Lance Lian’s stem cell research

The latest episode of "Life From All Angles," a YouTube series from the Huck Institutes of the Life Sciences, features Associate Professor of Biomedical Engineering Xiaojun "Lance" Lian and his efforts to produce new cardiomyocytes to advance the effectiveness of stem cell differentiation.

Game-changing stem cell engineer Lance Lian featured on Symbiotic podcast

Xiaojun “Lance” Lian, associate professor of biomedical engineering, is set to be the Symbiotic podcast’s final guest for 2022 when he appears at noon on Wednesday, Sept. 28 on the Huck Institutes of the Life Sciences’ livestream page.

Penn State-led team develops more efficient system for delivering CRISPR to stem cells

Modified mRNA (modRNA)-based CRISPR systems improve on the transfection and knockout efficiency of plasmid-based systems in human pluripotent stem cells (hPSCs), a Penn State-led team of interdisciplinary researchers has found.

New approach more than doubles stem cell editing efficiency, researchers report

A Penn State-led team of interdisciplinary researchers has developed techniques to improve the efficiency of CRISPR-Cas9, the genome editing technique that earned the Nobel Prize in 2020.

Studying diseases with better delivery of gene-editing tools

Using gene-editing tools with stem cells can be challenging because their delivery into cells can be inefficient, time-consuming, or expensive. A Penn State-led team of interdisciplinary researchers has developed a method that improves the lifespan and efficiency of CRISPR gene-editing tools after delivery.