Xiang Zhu

Assistant Professor of Statistics

Xiang Zhu

Research Summary

Statistical Genetics and Genomics

Huck Affiliations

Links

Publication Tags

Genes Genome Chromatin Soil Nitrogen Water Phenotype Genome Wide Association Study Statistics Cardiovascular Diseases Abdominal Aortic Aneurysm China Peripheral Arterial Disease Meta Analysis Lysine Lipids Gene Expression History Effect Lipoproteins Blood Vessels Genetic Variation Nematode Histone Topology

Most Recent Papers

A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation

Marijana Vujkovic, Shweta Ramdas, Kim Lorenz, Xiuqing Guo, Rebecca Darlay, Heather Cordell, Jing He, Yevgeniy Gindin, Chuhan Chung, Robert Myers, Carolin Schneider, Joseph Park, Kyung Lee, Marina Serper, Rotonya Carr, David Kaplan, Mary Haas, Matthew MacLean, Walter Witschey, Xiang Zhu, Catherine Tcheandjieu, Rachel Kember, Henry Kranzler, Anurag Verma, Ayush Giri, Derek Klarin, Yan Sun, Jie Huang, Jennifer Huffman, Kate Townsend Creasy, Nicholas Hand, Ching-Ti Liu, Michelle Long, Jie Yao, Matthew Budoff, Jingyi Tan, Xiaohui Li, Henry Lin, Yii-Der Chen, Kent Taylor, Ruey-Kang Chang, Ronald Krauss, Silvia Vilarinho, Joseph Brancale, Jonas Nielsen, Adam Locke, Marcus Jones, Niek Verweij, Aris Baras, K. Reddy, Brent Neuschwander-Tetri, Jeffrey Schwimmer, Arun Sanyal, Naga Chalasani, Kathleen Ryan, Braxton Mitchell, Dipender Gill, Andrew Wells, Elisabetta Manduchi, Yedidya Saiman, Nadim Mahmud, Donald Miller, Peter Reaven, Lawrence Phillips, Sumitra Muralidhar, Scott DuVall, Jennifer Lee, Themistocles Assimes, Saiju Pyarajan, Kelly Cho, Todd Edwards, Scott Damrauer, Peter Wilson, J. Gaziano, Christopher O’Donnell, Amit Khera, Struan Grant, Christopher Brown, Philip Tsao, Danish Saleheen, Luca Lotta, Lisa Bastarache, Quentin Anstee, Ann Daly, James Meigs, Jerome Rotter, Julie Lynch, Daniel Rader, Benjamin Voight, Kyong-Mi Chang, 2022, Nature Genetics on p. 761-771

Leveraging cell-type-specific regulatory networks to interpret genetic variants in abdominal aortic aneurysm

Shining Ma, Xi Chen, Xiang Zhu, Philip S. Tsao, Wing Hung Wong, 2022, Proceedings of the National Academy of Sciences of the United States of America

The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham, Shoa L. Clarke, Kuan Han H. Wu, Stavroula Kanoni, Greg J.M. Zajac, Shweta Ramdas, Ida Surakka, Ioanna Ntalla, Sailaja Vedantam, Thomas W. Winkler, Adam E. Locke, Eirini Marouli, Mi Yeong Hwang, Sohee Han, Akira Narita, Ananyo Choudhury, Amy R. Bentley, Kenneth Ekoru, Anurag Verma, Bhavi Trivedi, Hilary C. Martin, Karen A. Hunt, Qin Hui, Derek Klarin, Xiang Zhu, Gudmar Thorleifsson, Anna Helgadottir, Daniel F. Gudbjartsson, Hilma Holm, Isleifur Olafsson, Masato Akiyama, Saori Sakaue, Chikashi Terao, Masahiro Kanai, Wei Zhou, Ben M. Brumpton, Humaira Rasheed, Sanni E. Ruotsalainen, Aki S. Havulinna, Yogasudha Veturi, Qi Ping Feng, Elisabeth A. Rosenthal, Todd Lingren, Jennifer Allen Pacheco, Sarah A. Pendergrass, Jeffrey Haessler, Franco Giulianini, Yuki Bradford, Jason E. Miller, Archie Campbell, 2021, Nature on p. 675-679

Modeling regulatory network topology improves genome-wide analyses of complex human traits

Xiang Zhu, Zhana Duren, Wing Hung Wong, 2021, Nature Communications

The genetic architecture of DNA replication timing in human pluripotent stem cells

Qiliang Ding, Matthew M. Edwards, Ning Wang, Xiang Zhu, Alexa N. Bracci, Michelle L. Hulke, Ya Hu, Yao Tong, Joyce Hsiao, Christine J. Charvet, Sulagna Ghosh, Robert E. Handsaker, Kevin Eggan, Florian T. Merkle, Jeannine Gerhardt, Dieter Egli, Andrew G. Clark, Amnon Koren, 2021, Nature Communications

A genome-wide association study of chronic ALT-based NAFLD in the Million Veteran Program with histological and radiological validation

Marijana Vujkovic, Shweta Ramdas, Kimberly Lorenz, Xiuqing Guo, Rebecca Darlay, Heather Cordell, Jing He, Yevgeniy Gindin, Chuhan Chung, Robert Myers, Carolin Schneider, Joseph Park, Kyung Lee, Marina Serper, Rotonya Carr, David Kaplan, Mary Haas, Matthew MacLean, Walter Witschey, Xiang Zhu, Catherine Tcheandjieu, Rachel Kember, Henry Kranzler, Anurag Verma, Ayush Giri, Derek Klarin, Yan Sun, Jie Huang, Jennifer Huffman, Kate Creasy, Nicholas Hand, Ching-Ti Liu, Michelle Long, Jie Yao, Xiaohui Li, Matthew Budoff, Jingyi Tan, Henry Lin, Yii-Der Chen, Kent Taylor, Ruey-Kang Chang, Ronald Krauss, Silvia Vilarinho, Joseph Brancale, Jonas Nielsen, Adam Locke, Niek Verweij, Marcus Jones, Aris Baras, K. Rajender Reddy, Brent Neuschwander-Tetri, Jeffrey Schwimmer, Arun Sanyal, Naga Chalasani, Kathleen Ryan, Braxton Mitchell, Dipender Gill, Andrew Wells, Elisabetta Manduchi, Yedidya Saiman, Nadim Mahmud, Donald Miller, Peter Reaven, Lawrence Phillips, Sumitra Muralidhar, Scott DuVall, Jennifer Lee, Themistocles Assimes, Saiju Pyarajan, Kelly Cho, Todd Edwards, Scott Damrauer, Peter Wilson, J. Michael Gaziano, Christopher O’Donnell, Amit Khera, Struan Grant, Christopher Brown, Philip Tsao, Danish Saleheen, Luca Lotta, Lisa Bastarache, Quentin Anstee, Ann Daly, James Meigs, Jerome Rotter, Julie Lynch, Daniel Rader, Benjamin Voight, Kyong-Mi Chang, Regeneron Genetics Center, DiscovEHR Collaboration, EPoS Consortium Investigators, Million Veteran Program, 2021, Hepatology on p. 6-7

Associations of Genetically Predicted Lipoprotein (a) Levels With Cardiovascular Traits in Individuals of European and African Ancestry

Benjamin Satterfield, Ozan Dikilitas, Maya Safarova, Shoa Clarke, Catherine Tcheandjieu, Xiang Zhu, Lisa Bastarache, Eric Larson, Anne Justice, Ning Shang, Elisabeth Rosenthal, Amy Shah, Bahram Namjou-Khales, Elaine Urbina, Wei-Qi Wei, QiPing Feng, Gail Jarvik, Scott Hebbring, Mariza de Andrade, Teri Manolio, Themistocles Assimes, Iftikhar Kullo, 2021, Circulation. Genomic and precision medicine on p. e003354

Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation

Jingxue Xin, Hui Zhang, Yaoxi He, Zhana Duren, Caijuan Bai, Lang Chen, Xin Luo, Dong Sheng Yan, Chaoyu Zhang, Xiang Zhu, Qiuyue Yuan, Zhanying Feng, Chaoying Cui, Xuebin Qi, Ouzhuluobu, Wing Hung Wong, Yong Wang, Bing Su, 2020, Nature Communications

LPA variants are associated with aortic valve stenosis, heart failure and chronic kidney disease

Ozan Dikilitas, Benjamin Satterfield, Maya Safarova, Shoa Clarke, Catherine Tcheandjieu, Xiang Zhu, Lisa Bastarache, eric LARSON, Anne Justice, Ning Shang, Elisabeth Rosenthal, Amy Shah, Bahram Namjou-Khales, Elaine Urbina, Wei-Qi Wei, Qiping Feng, Scott Hebbring, Gail Jarvik, Mariza de Andrade, Teri Manolio, Themistocles Assimes, Iftikhar Kullo, 2020, Circulation on p. A15209

Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

Marijana Vujkovic, Jacob M. Keaton, Julie A. Lynch, Donald R. Miller, Jin Zhou, Catherine Tcheandjieu, Jennifer E. Huffman, Themistocles L. Assimes, Kimberly Lorenz, Xiang Zhu, Austin T. Hilliard, Renae L. Judy, Jie Huang, Kyung M. Lee, Derek Klarin, Saiju Pyarajan, John Danesh, Olle Melander, Asif Rasheed, Nadeem H. Mallick, Shahid Hameed, Irshad H. Qureshi, Muhammad Naeem Afzal, Uzma Malik, Anjum Jalal, Shahid Abbas, Xin Sheng, Long Gao, Klaus H. Kaestner, Katalin Susztak, Yan V. Sun, Scott L. DuVall, Kelly Cho, Jennifer S. Lee, J. Michael Gaziano, Lawrence S. Phillips, James B. Meigs, Peter D. Reaven, Peter W. Wilson, Todd L. Edwards, Daniel J. Rader, Scott M. Damrauer, Christopher J. O’Donnell, Philip S. Tsao, Mark A. Atkinson, Al C. Powers, Ali Naji, Klaus H. Kaestner, Goncalo R. Abecasis, Aris Baras, 2020, Nature Genetics on p. 680-691

Most-Cited Papers

Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

Marijana Vujkovic, Jacob M. Keaton, Julie A. Lynch, Donald R. Miller, Jin Zhou, Catherine Tcheandjieu, Jennifer E. Huffman, Themistocles L. Assimes, Kimberly Lorenz, Xiang Zhu, Austin T. Hilliard, Renae L. Judy, Jie Huang, Kyung M. Lee, Derek Klarin, Saiju Pyarajan, John Danesh, Olle Melander, Asif Rasheed, Nadeem H. Mallick, Shahid Hameed, Irshad H. Qureshi, Muhammad Naeem Afzal, Uzma Malik, Anjum Jalal, Shahid Abbas, Xin Sheng, Long Gao, Klaus H. Kaestner, Katalin Susztak, Yan V. Sun, Scott L. DuVall, Kelly Cho, Jennifer S. Lee, J. Michael Gaziano, Lawrence S. Phillips, James B. Meigs, Peter D. Reaven, Peter W. Wilson, Todd L. Edwards, Daniel J. Rader, Scott M. Damrauer, Christopher J. O’Donnell, Philip S. Tsao, Mark A. Atkinson, Al C. Powers, Ali Naji, Klaus H. Kaestner, Goncalo R. Abecasis, Aris Baras, 2020, Nature Genetics on p. 680-691

Bayesian large-scale multiple regression with summary statistics from genome-wide association studies

Xiang Zhu, Matthew Stephens, 2017, Annals of Applied Statistics on p. 1561-1592

The Response of Soil Nematode Community to Nitrogen, Water, and Grazing History in the Inner Mongolian Steppe, China

Wei bin Ruan, Yuan Sang, Qing Chen, Xiang Zhu, Shan Lin, Yu bao Gao, 2012, Ecosystems on p. 1121-1133

Large-scale genome-wide enrichment analyses identify new trait-associated genes and pathways across 31 human phenotypes

Xiang Zhu, Matthew Stephens, 2018, Nature Communications

Opposing effects of nitrogen and water addition on soil bacterial and fungal communities in the Inner Mongolia steppe: A field experiment

Hai kun Ma, Guang ying Bai, Yang Sun, Olga Kostenko, Xiang Zhu, Shan Lin, Wei bin Ruan, Nian xi Zhao, T. Martijn Bezemer, 2016, Applied Soil Ecology on p. 128-135

Effects of conventional and reduced N inputs on nematode communities and plant yield under intensive vegetable production

Wei Bin Ruan, Tao Ren, Qing Chen, Xiang Zhu, Jing Guo Wang, 2013, Applied Soil Ecology on p. 48-55

Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation

Jingxue Xin, Hui Zhang, Yaoxi He, Zhana Duren, Caijuan Bai, Lang Chen, Xin Luo, Dong Sheng Yan, Chaoyu Zhang, Xiang Zhu, Qiuyue Yuan, Zhanying Feng, Chaoying Cui, Xuebin Qi, Ouzhuluobu, Wing Hung Wong, Yong Wang, Bing Su, 2020, Nature Communications

The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham, Shoa L. Clarke, Kuan Han H. Wu, Stavroula Kanoni, Greg J.M. Zajac, Shweta Ramdas, Ida Surakka, Ioanna Ntalla, Sailaja Vedantam, Thomas W. Winkler, Adam E. Locke, Eirini Marouli, Mi Yeong Hwang, Sohee Han, Akira Narita, Ananyo Choudhury, Amy R. Bentley, Kenneth Ekoru, Anurag Verma, Bhavi Trivedi, Hilary C. Martin, Karen A. Hunt, Qin Hui, Derek Klarin, Xiang Zhu, Gudmar Thorleifsson, Anna Helgadottir, Daniel F. Gudbjartsson, Hilma Holm, Isleifur Olafsson, Masato Akiyama, Saori Sakaue, Chikashi Terao, Masahiro Kanai, Wei Zhou, Ben M. Brumpton, Humaira Rasheed, Sanni E. Ruotsalainen, Aki S. Havulinna, Yogasudha Veturi, Qi Ping Feng, Elisabeth A. Rosenthal, Todd Lingren, Jennifer Allen Pacheco, Sarah A. Pendergrass, Jeffrey Haessler, Franco Giulianini, Yuki Bradford, Jason E. Miller, Archie Campbell, 2021, Nature on p. 675-679

The genetic architecture of DNA replication timing in human pluripotent stem cells

Qiliang Ding, Matthew M. Edwards, Ning Wang, Xiang Zhu, Alexa N. Bracci, Michelle L. Hulke, Ya Hu, Yao Tong, Joyce Hsiao, Christine J. Charvet, Sulagna Ghosh, Robert E. Handsaker, Kevin Eggan, Florian T. Merkle, Jeannine Gerhardt, Dieter Egli, Andrew G. Clark, Amnon Koren, 2021, Nature Communications

Associations of Genetically Predicted Lipoprotein (a) Levels With Cardiovascular Traits in Individuals of European and African Ancestry

Benjamin Satterfield, Ozan Dikilitas, Maya Safarova, Shoa Clarke, Catherine Tcheandjieu, Xiang Zhu, Lisa Bastarache, Eric Larson, Anne Justice, Ning Shang, Elisabeth Rosenthal, Amy Shah, Bahram Namjou-Khales, Elaine Urbina, Wei-Qi Wei, QiPing Feng, Gail Jarvik, Scott Hebbring, Mariza de Andrade, Teri Manolio, Themistocles Assimes, Iftikhar Kullo, 2021, Circulation. Genomic and precision medicine on p. e003354