William Hancock
Professor of Bioengineering
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430 Chemical and Biomedical Engineering
University Park, PA - woh1@psu.edu
- 814-863-0492
Research Summary
The detailed workings of motor proteins and their role in intracellular transport and cell motility.
Huck Graduate Students
Huck Affiliations
Most Recent Publications
Lignin impairs Cel7A degradation of in vitro lignified cellulose by impeding enzyme movement and not by acting as a sink
Zachary K. Haviland, Daguan Nong, Nerya Zexer, Ming Tien, Charles T. Anderson, William O. Hancock, 2024, Biotechnology for Biofuels and Bioproducts
Measuring PETase enzyme kinetics by single-molecule microscopy
Yuwei Zhang, William O. Hancock, 2024, Biophysical Journal on p. 3669-3677
Single-molecule tracking reveals dual front door/back door inhibition of Cel7A cellulase by its product cellobiose.
D Nong, Z Haviland, N Zexer, S Pfaff, Daniel Cosgrove, M Tien, Charles T. Anderson, William O. Hancock, 2024, Proceedings of the National Academy of Sciences of the United States of America on p. e2322567121
Xylan inhibition of cellulase binding and processivity observed at single-molecule resolution
Nerya Zexer, Alec Paradiso, Daguan Nong, Zachary K. Haviland, William O. Hancock, Charles T. Anderson, 2024, RSC Sustainability on p. 1118-1127
Interface-acting nucleotide controls polymerization dynamics at microtubule plus-and minus-ends
Lauren A. McCormick, Joseph M. Cleary, William O. Hancock, Luke M. Rice, 2024, eLife
Simulations suggest robust microtubule attachment of kinesin and dynein in antagonistic pairs
Tzu Chen Ma, Allison M. Gicking, Qingzhou Feng, William O. Hancock, 2023, Biophysical Journal on p. 3299-3313
Kinesin-1, -2 and -3 use family-specific mechanochemical strategies to effectively compete with dynein during bidirectional transport
Allison M. Gicking, Tzu Chen Ma, Qingzhou Feng, Rui Jiang, Somaye Badieyan, Michael A. Cianfrocco, William O. Hancock, 2023, Biophysical Journal on p. 411a
Positive charge in the K-loop of the kinesin-3 motor KIF1A regulates superprocessivity by enhancing microtubule affinity in the one-head–bound state
Taylor M. Zaniewski, William O. Hancock, 2023, Journal of Biological Chemistry
KIF1A is kinetically tuned to be a superengaging motor under hindering loads
Serapion Pyrpassopoulos, Allison M. Gicking, Taylor M. Zaniewski, William O. Hancock, E. Michael Ostap, 2023, Proceedings of the National Academy of Sciences of the United States of America
Manipulation of Force Geometry using Optical Tweezers Reveals Novel Features of Biomolecular Interactions
Serapion Pyrpassopoulos, Allison M. Gicking, Taylor M. Zaniewsky, Henry Shuman, William Hancock, E. Michael Ostap, 2023,
Most-Cited Papers
Examining kinesin processivity within a general gating framework
Johan O.L. Andreasson, Bojan Milic, Geng Yuan Chen, Nicholas R. Guydosh, William O. Hancock, Steven M. Block, 2015, eLife on p. 1-44
Kinetics of nucleotide-dependent structural transitions in the kinesin-1 hydrolysis cycle
Keith J. Mickolajczyk, Nathan C. Deffenbaugh, Jaime Ortega Arroyo, Joanna Andrecka, Philipp Kukura, William O. Hancock, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. E7186-E7193
Kinesin-5 is a microtubule polymerase
Yalei Chen, William O. Hancock, 2015, Nature Communications
The Kinesin-1 Chemomechanical Cycle: Stepping Toward a Consensus
William O. Hancock, 2016, Biophysical Journal on p. 1216-1225
The mechanochemical cycle of mammalian kinesin-2 KIF3A/B under load
Johan O.L. Andreasson, Shankar Shastry, William O. Hancock, Steven M. Block, 2015, Current Biology on p. 1166-1175
A Tubulin Binding Switch Underlies Kip3/Kinesin-8 Depolymerase Activity
Hugo Arellano-Santoyo, Elisabeth A. Geyer, Ema Stokasimov, Geng Yuan Chen, Xiaolei Su, William Hancock, Luke M. Rice, David Pellman, 2017, Developmental Cell on p. 37-51.e8
Direct observation of individual tubulin dimers binding to growing microtubules
Keith J. Mickolajczyk, Elisabeth A. Geyer, Tae Kim, Luke M. Rice, William O. Hancock, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 7314-7322
Motor Reattachment Kinetics Play a Dominant Role in Multimotor-Driven Cargo Transport
Qingzhou Feng, Keith J. Mickolajczyk, Geng Yuan Chen, William O. Hancock, 2018, Biophysical Journal on p. 400-409
Kinesin Processivity Is Determined by a Kinetic Race from a Vulnerable One-Head-Bound State
Keith J. Mickolajczyk, William O. Hancock, 2017, Biophysical Journal on p. 2615-2623
Processivity of the Kinesin-2 KIF3A results from rear head gating and not front head gating
Geng Yuan Chen, David F.J. Arginteanu, William O. Hancock, 2015, Journal of Biological Chemistry on p. 10274-10294
News Articles Featuring William Hancock
Sep 11, 2024
Three projects receive Huck Innovative and Transformational Seed Fund grants
Three potentially high-impact, high-risk research projects have been selected to receive seed funding for the latest round of the Huck Innovative and Transformational Seed (HITS) Fund initiative.
Full Article
Apr 11, 2023
Study on how neurons move offers new insight into neurodegenerative diseases
Neurons, which are responsible for producing the signals that ultimately trigger an action like talking or moving a muscle, are built and maintained by classes of motor proteins that transport molecular cargo along elongated tracks called microtubules.
Full Article
Apr 11, 2019
New SCATTIRSTORM microscope could improve bioenergy production
The construction of a new multimodal optical microscope, SCATTIRSTORM, that could enable more efficient bioenergy production, is the focus of a three-year, $1.5 million, U.S. Department of Energy grant awarded to three Penn State researchers.
Full Article