William Hancock

Professor of Bioengineering

William Hancock

Research Summary

The detailed workings of motor proteins and their role in intracellular transport and cell motility.

Huck Affiliations

Publication Tags

Kinesin Microtubules Hydrolysis Adenosine Triphosphate Kinetics Proteins Fluorescence Head Cellulose Tubulin Neck Polymerization Enzymes Growth Velocity Dissection Giardia Quantum Dots Protein Microscopy Length Dyneins Fluorescence Microscopy Homodimer Polymerization Reaction

Most Recent Publications

Measurement of the persistence length of cytoskeletal filaments using curvature distributions

Pattipong Wisanpitayakorn, Keith J. Mickolajczyk, William O. Hancock, Luis Vidali, Erkan Tüzel, 2022, Biophysical Journal on p. 1813-1822

Measurements and simulations of microtubule growth imply strong longitudinal interactions and reveal a role for GDP on the elongating end

Joseph M. Cleary, Tae Kim, Annan S.I. Cook, Lauren A. McCormick, William O. Hancock, Luke M. Rice, 2022, eLife

Measuring microtubule binding kinetics of membrane-bound kinesin motors using supported lipid bilayers

Rui Jiang, William O. Hancock, 2021, STAR Protocols

Nanoscale dynamics of cellulose digestion by the cellobiohydrolase TrCel7A

Zachary K. Haviland, Daguan Nong, Kate L.Vasquez Kuntz, Thomas J. Starr, Dengbo Ma, Ming Tien, Charles T. Anderson, William O. Hancock, 2021, Journal of Biological Chemistry

Integrated multi-wavelength microscope combining TIRFM and IRM modalities for imaging cellulases and other processive enzymes

Daguan Nong, Zachary K. Haviland, Kate Vasquez Kuntz, Ming Tien, Charles T. Anderson, William O. Hancock, 2021, Biomedical Optics Express on p. 3253-3264

Trim9 and Klp61F promote polymerization of new dendritic microtubules along parallel microtubules

Chengye Feng, Joseph M. Cleary, Gregory O. Kothe, Michelle C. Stone, Alexis T. Weiner, James I. Hertzler, William O. Hancock, Melissa M. Rolls, 2021, The Quarterly journal of microscopical science

Molecular mechanisms underlying microtubule growth dynamics

Joseph M. Cleary, William O. Hancock, 2021, Current Biology on p. R560-R573

A change point analysis protocol for comparing intracellular transport by different molecular motor combinations

Melanie A. Jensen, Qingzhou Feng, William O. Hancock, Scott A. McKinley, 2021, Mathematical Biosciences and Engineering on p. 8962-8996

A kinetic dissection of the fast and superprocessive kinesin-3 KIF1A reveals a predominant one-head-bound state during its chemomechanical cycle

Taylor M. Zaniewski, Allison M. Gicking, John Fricks, William O. Hancock, 2020, Journal of Biological Chemistry on p. 17889-17903

The Tail of Kinesin-14a in Giardia Is a Dual Regulator of Motility

Kuo Fu Tseng, Keith J. Mickolajczyk, Guangxi Feng, Qingzhou Feng, Ethiene S. Kwok, Jesse Howe, Elisar J. Barbar, Scott C. Dawson, William O. Hancock, Weihong Qiu, 2020, Current Biology on p. 3664-3671.e4

Most-Cited Papers

Bidirectional cargo transport: Moving beyond tug of war

William O. Hancock, 2014, Nature Reviews Molecular Cell Biology on p. 615-628

Examining kinesin processivity within a general gating framework

Johan O.L. Andreasson, Bojan Milic, Geng Yuan Chen, Nicholas R. Guydosh, William O. Hancock, Steven M. Block, 2015, eLife on p. 1-44

Kinesin processivity is gated by phosphate release

Bojan Milic, Johan O.L. Andreasson, William O. Hancock, Steven M. Block, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 14136-14140

Kinetics of nucleotide-dependent structural transitions in the kinesin-1 hydrolysis cycle

Keith J. Mickolajczyk, Nathan C. Deffenbaugh, Jaime Ortega Arroyo, Joanna Andrecka, Philipp Kukura, William O. Hancock, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. E7186-E7193

Transport by populations of fast and slow kinesins uncovers novel family-dependent motor characteristics important for in vivo function

Göker Arpaʇ, Shankar Shastry, William O. Hancock, Erkan Tüzel, 2014, Biophysical Journal on p. 1896-1904

Kinesin-5 is a microtubule polymerase

Yalei Chen, William O. Hancock, 2015, Nature Communications

Kinesin's neck-linker determines its ability to navigate obstacles on the microtubule surface

Gregory J. Hoeprich, Andrew R. Thompson, Derrick P. McVicker, William O. Hancock, Christopher L. Berger, 2014, Biophysical Journal on p. 1691-1700

The mechanochemical cycle of mammalian kinesin-2 KIF3A/B under load

Johan O.L. Andreasson, Shankar Shastry, William O. Hancock, Steven M. Block, 2015, Current Biology on p. 1166-1175

The Kinesin-1 Chemomechanical Cycle: Stepping Toward a Consensus

William O. Hancock, 2016, Biophysical Journal on p. 1216-1225

Molecular counting by photobleaching in protein complexes with many subunits: Best practices and application to the cellulose synthesis complex

Yalei Chen, Nathan C. Deffenbaugh, Charles T. Anderson, William O. Hancock, 2014, Molecular Biology of the Cell on p. 3630-3642