William Hancock

Professor of Bioengineering

William Hancock

Research Summary

The detailed workings of motor proteins and their role in intracellular transport and cell motility.

Huck Graduate Students

Huck Affiliations

Publication Tags

Kinesin Microtubules Adenosine Triphosphate Tubulin Hydrolysis Kinetics Neck Proteins Head Polymerization Dissection Giardia Nucleotides Fluorescence Molecules Dyneins Population Nanoparticles Microscopy Gold Conformations Switches Cellulose Dynactin Complex Phosphates

Most Recent Papers

A kinetic dissection of the fast and superprocessive kinesin-3 KIF1A reveals a predominant one-head-bound state during its chemomechanical cycle

Taylor M. Zaniewski, Allison M. Gicking, John Fricks, William O. Hancock, 2020, Journal of Biological Chemistry on p. 17889-17903

The Tail of Kinesin-14a in Giardia Is a Dual Regulator of Motility

Kuo Fu Tseng, Keith J. Mickolajczyk, Guangxi Feng, Qingzhou Feng, Ethiene S. Kwok, Jesse Howe, Elisar J. Barbar, Scott C. Dawson, William O. Hancock, Weihong Qiu, 2020, Current Biology on p. 3664-3671.e4

Kinesin-2 from C. reinhardtii Is an Atypically Fast and Auto-inhibited Motor that Is Activated by Heterotrimerization for Intraflagellar Transport

Punam Sonar, Wiphu Youyen, Augustine Cleetus, Pattipong Wisanpitayakorn, Sayed I. Mousavi, Willi L. Stepp, William O. Hancock, Erkan Tüzel, Zeynep Ökten, 2020, Current Biology on p. 1160-1166.e5

Dynactin p150 promotes processive motility of DDB complexes by minimizing diffusional behavior of dynein

Qingzhou Feng, Allison M. Gicking, William O. Hancock, 2020, Molecular Biology of the Cell on p. 782-792

Three Beads Are Better Than One.

J Howard, William Hancock, 2020, Biophysical journal on p. 1-3

Microtubule binding kinetics of membrane-bound kinesin-1 predicts high motor copy numbers on intracellular cargo

Rui Jiang, Steven Vandal, Soohyun Park, Sheereen Majd, Erkan Tüzel, William O. Hancock, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 26564-26570

Insights into Kinesin-1 Stepping from Simulations and Tracking of Gold Nanoparticle-Labeled Motors

Keith J. Mickolajczyk, Annan S.I. Cook, Janak P. Jevtha, John Fricks, William O. Hancock, 2019, Biophysical Journal on p. 331-345

Kinesin-5 Promotes Microtubule Nucleation and Assembly by Stabilizing a Lattice-Competent Conformation of Tubulin

Geng Yuan Chen, Joseph M. Cleary, A. B. Asenjo, Y. Chen, Jacob A. Mascaro, David Florn Johnso Arginteanu, Hernando Sosa, William O. Hancock, 2019, Current Biology on p. 2259-2269.e4

Direct observation of individual tubulin dimers binding to growing microtubules

Keith J. Mickolajczyk, Elisabeth A. Geyer, Tae Kim, Luke M. Rice, William O. Hancock, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 7314-7322

The Orphan Kinesin PAKRP2 Achieves Processive Motility via a Noncanonical Stepping Mechanism

Allison M. Gicking, Pan Wang, Chun Liu, Keith J. Mickolajczyk, Lijun Guo, William O. Hancock, Weihong Qiu, 2019, Biophysical Journal on p. 1270-1281

Most-Cited Papers

Examining kinesin processivity within a general gating framework

Johan O.L. Andreasson, Bojan Milic, Geng Yuan Chen, Nicholas R. Guydosh, William O. Hancock, Steven M. Block, 2015, eLife on p. 1-44

Kinesin processivity is gated by phosphate release

Bojan Milic, Johan O L Andreasson, William O. Hancock, Steven M. Block, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 14136-14140

Kinetics of nucleotide-dependent structural transitions in the kinesin-1 hydrolysis cycle

Keith J. Mickolajczyk, Nathan C. Deffenbaugh, Jaime Ortega Arroyo, Joanna Andrecka, Philipp Kukura, William O. Hancock, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. E7186-E7193

Interhead tension determines processivity across diverse N-terminal kinesins

Shankar Shastry, William O. Hancock, 2011, Proceedings of the National Academy of Sciences of the United States of America on p. 16253-16258

Transport by populations of fast and slow kinesins uncovers novel family-dependent motor characteristics important for in vivo function

Göker Arpaʇ, Shankar Shastry, William O. Hancock, Erkan Tüzel, 2014, Biophysical Journal on p. 1896-1904

Kinesin's neck-linker determines its ability to navigate obstacles on the microtubule surface

Gregory J. Hoeprich, Andrew R. Thompson, Derrick P. McVicker, William O. Hancock, Christopher L. Berger, 2014, Biophysical Journal on p. 1691-1700

The mechanochemical cycle of mammalian kinesin-2 KIF3A/B under load

Johan O.L. Andreasson, Shankar Shastry, William O. Hancock, Steven M. Block, 2015, Current Biology on p. 1166-1175

Kinesin-5 is a microtubule polymerase

Yalei Chen, William O. Hancock, 2015, Nature Communications

Molecular counting by photobleaching in protein complexes with many subunits: Best practices and application to the cellulose synthesis complex

Yalei Chen, Nathan C. Deffenbaugh, Charles T. Anderson, William O. Hancock, 2014, Molecular Biology of the Cell on p. 3630-3642

A Tubulin Binding Switch Underlies Kip3/Kinesin-8 Depolymerase Activity

Hugo Arellano-Santoyo, Elisabeth A. Geyer, Ema Stokasimov, Geng Yuan Chen, Xiaolei Su, William Hancock, Luke M. Rice, David Pellman, 2017, Developmental Cell on p. 37-51.e8