William Hancock
Professor of Bioengineering

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229 Hallowell
University Park, PA - woh1@psu.edu
- 814-863-0492
Research Summary
The detailed workings of motor proteins and their role in intracellular transport and cell motility.
Huck Graduate Students
Huck Affiliations
Publication Tags
Kinesin Microtubules Adenosine Triphosphate Tubulin Hydrolysis Kinetics Neck Proteins Head Polymerization Dissection Giardia Nucleotides Fluorescence Molecules Dyneins Population Nanoparticles Microscopy Gold Conformations Switches Cellulose Dynactin Complex PhosphatesMost Recent Papers
A kinetic dissection of the fast and superprocessive kinesin-3 KIF1A reveals a predominant one-head-bound state during its chemomechanical cycle
Taylor M. Zaniewski, Allison M. Gicking, John Fricks, William O. Hancock, 2020, Journal of Biological Chemistry on p. 17889-17903
The Tail of Kinesin-14a in Giardia Is a Dual Regulator of Motility
Kuo Fu Tseng, Keith J. Mickolajczyk, Guangxi Feng, Qingzhou Feng, Ethiene S. Kwok, Jesse Howe, Elisar J. Barbar, Scott C. Dawson, William O. Hancock, Weihong Qiu, 2020, Current Biology on p. 3664-3671.e4
Kinesin-2 from C. reinhardtii Is an Atypically Fast and Auto-inhibited Motor that Is Activated by Heterotrimerization for Intraflagellar Transport
Punam Sonar, Wiphu Youyen, Augustine Cleetus, Pattipong Wisanpitayakorn, Sayed I. Mousavi, Willi L. Stepp, William O. Hancock, Erkan Tüzel, Zeynep Ökten, 2020, Current Biology on p. 1160-1166.e5
Dynactin p150 promotes processive motility of DDB complexes by minimizing diffusional behavior of dynein
Qingzhou Feng, Allison M. Gicking, William O. Hancock, 2020, Molecular Biology of the Cell on p. 782-792
Three Beads Are Better Than One.
J Howard, William Hancock, 2020, Biophysical journal on p. 1-3
Microtubule binding kinetics of membrane-bound kinesin-1 predicts high motor copy numbers on intracellular cargo
Rui Jiang, Steven Vandal, Soohyun Park, Sheereen Majd, Erkan Tüzel, William O. Hancock, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 26564-26570
Insights into Kinesin-1 Stepping from Simulations and Tracking of Gold Nanoparticle-Labeled Motors
Keith J. Mickolajczyk, Annan S.I. Cook, Janak P. Jevtha, John Fricks, William O. Hancock, 2019, Biophysical Journal on p. 331-345
Kinesin-5 Promotes Microtubule Nucleation and Assembly by Stabilizing a Lattice-Competent Conformation of Tubulin
Geng Yuan Chen, Joseph M. Cleary, A. B. Asenjo, Y. Chen, Jacob A. Mascaro, David Florn Johnso Arginteanu, Hernando Sosa, William O. Hancock, 2019, Current Biology on p. 2259-2269.e4
Direct observation of individual tubulin dimers binding to growing microtubules
Keith J. Mickolajczyk, Elisabeth A. Geyer, Tae Kim, Luke M. Rice, William O. Hancock, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 7314-7322
The Orphan Kinesin PAKRP2 Achieves Processive Motility via a Noncanonical Stepping Mechanism
Allison M. Gicking, Pan Wang, Chun Liu, Keith J. Mickolajczyk, Lijun Guo, William O. Hancock, Weihong Qiu, 2019, Biophysical Journal on p. 1270-1281
Most-Cited Papers
Examining kinesin processivity within a general gating framework
Johan O.L. Andreasson, Bojan Milic, Geng Yuan Chen, Nicholas R. Guydosh, William O. Hancock, Steven M. Block, 2015, eLife on p. 1-44
Kinesin processivity is gated by phosphate release
Bojan Milic, Johan O L Andreasson, William O. Hancock, Steven M. Block, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 14136-14140
Kinetics of nucleotide-dependent structural transitions in the kinesin-1 hydrolysis cycle
Keith J. Mickolajczyk, Nathan C. Deffenbaugh, Jaime Ortega Arroyo, Joanna Andrecka, Philipp Kukura, William O. Hancock, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. E7186-E7193
Interhead tension determines processivity across diverse N-terminal kinesins
Shankar Shastry, William O. Hancock, 2011, Proceedings of the National Academy of Sciences of the United States of America on p. 16253-16258
Transport by populations of fast and slow kinesins uncovers novel family-dependent motor characteristics important for in vivo function
Göker Arpaʇ, Shankar Shastry, William O. Hancock, Erkan Tüzel, 2014, Biophysical Journal on p. 1896-1904
Kinesin's neck-linker determines its ability to navigate obstacles on the microtubule surface
Gregory J. Hoeprich, Andrew R. Thompson, Derrick P. McVicker, William O. Hancock, Christopher L. Berger, 2014, Biophysical Journal on p. 1691-1700
The mechanochemical cycle of mammalian kinesin-2 KIF3A/B under load
Johan O.L. Andreasson, Shankar Shastry, William O. Hancock, Steven M. Block, 2015, Current Biology on p. 1166-1175
Kinesin-5 is a microtubule polymerase
Yalei Chen, William O. Hancock, 2015, Nature Communications
Molecular counting by photobleaching in protein complexes with many subunits: Best practices and application to the cellulose synthesis complex
Yalei Chen, Nathan C. Deffenbaugh, Charles T. Anderson, William O. Hancock, 2014, Molecular Biology of the Cell on p. 3630-3642
A Tubulin Binding Switch Underlies Kip3/Kinesin-8 Depolymerase Activity
Hugo Arellano-Santoyo, Elisabeth A. Geyer, Ema Stokasimov, Geng Yuan Chen, Xiaolei Su, William Hancock, Luke M. Rice, David Pellman, 2017, Developmental Cell on p. 37-51.e8
News Articles Featuring William Hancock
Apr 11, 2019
New SCATTIRSTORM microscope could improve bioenergy production
The construction of a new multimodal optical microscope, SCATTIRSTORM, that could enable more efficient bioenergy production, is the focus of a three-year, $1.5 million, U.S. Department of Energy grant awarded to three Penn State researchers.
Full Article