William Hancock
Professor of Bioengineering
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430 Chemical and Biomedical Engineering
University Park, PA - woh1@psu.edu
- 814-863-0492
Research Summary
The detailed workings of motor proteins and their role in intracellular transport and cell motility.
Huck Affiliations
Publication Tags
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Kinesin Microtubules Hydrolysis Dyneins Adenosine Triphosphate Force Neck Proteins Head Kinetics Velocity Aptitude Nucleotides Polymerization In Vitro Techniques Length Polymerization Reaction Tubulin Dynactin Complex Fluorescence Simulation Protein Population Growth MoleculesMost Recent Publications
Simulations suggest robust microtubule attachment of kinesin and dynein in antagonistic pairs
Tzu Chen Ma, Allison M. Gicking, Qingzhou Feng, William O. Hancock, 2023, Biophysical Journal on p. 3299-3313
Kinesin-1, -2 and -3 use family-specific mechanochemical strategies to effectively compete with dynein during bidirectional transport
Allison M. Gicking, Tzu Chen Ma, Qingzhou Feng, Rui Jiang, Somaye Badieyan, Michael A. Cianfrocco, William O. Hancock, 2023, Biophysical Journal on p. 411a
Positive charge in the K-loop of the kinesin-3 motor KIF1A regulates superprocessivity by enhancing microtubule affinity in the one-head–bound state
Taylor M. Zaniewski, William O. Hancock, 2023, Journal of Biological Chemistry
KIF1A is kinetically tuned to be a superengaging motor under hindering loads
Serapion Pyrpassopoulos, Allison M. Gicking, Taylor M. Zaniewski, William O. Hancock, E. Michael Ostap, 2023, Proceedings of the National Academy of Sciences of the United States of America
High-Resolution Tracking of Dynein-Dynactin-BicD2 Complexes
Qingzhou Feng, Allison M. Gicking, William O. Hancock, 2023, on p. 177-186
Synergy between inhibitors of two mitotic spindle assembly motors undermines an adaptive response
A Solon, T Zaniewski, Patrick O’Brien, P O'Brien, M Clasby, William Hancock, R Ohi, 2022, Molecular Biology of the Cell on p. ar132
Intracellular transport: KIF1C produces force along with a few slips
William Hancock, 2022, Current Biology on p. R914-R916
Kinesin-1,-2, and-3 motors use family-specific mechanochemical strategies to effectively compete with dynein during bidirectional transport
A Gicking, T Ma, Q Feng, R Jiang, S Badieyan, M Cianfrocco, William Hancock, 2022, eLife
Measurement of the persistence length of cytoskeletal filaments using curvature distributions
P Wisanpitayakorn, K Mickolajczyk, William Hancock, L Vidali, E Tüzel, 2022, Biophysical Journal on p. 1813-1822
Measurements and simulations of microtubule growth imply strong longitudinal interactions and reveal a role for GDP on the elongating end
J Cleary, T Kim, Annan S.I. Cook, Cook ASI, L McCormick, William Hancock, L Rice, 2022, eLife
Most-Cited Papers
Bidirectional cargo transport: Moving beyond tug of war
William O. Hancock, 2014, Nature Reviews Molecular Cell Biology on p. 615-628
Examining kinesin processivity within a general gating framework
Johan O.L. Andreasson, Bojan Milic, Geng Yuan Chen, Nicholas R. Guydosh, William O. Hancock, Steven M. Block, 2015, eLife on p. 1-44
Kinesin processivity is gated by phosphate release
Bojan Milic, Johan O.L. Andreasson, William O. Hancock, Steven M. Block, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 14136-14140
Kinetics of nucleotide-dependent structural transitions in the kinesin-1 hydrolysis cycle
Keith J. Mickolajczyk, Nathan C. Deffenbaugh, Jaime Ortega Arroyo, Joanna Andrecka, Philipp Kukura, William O. Hancock, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. E7186-E7193
Kinesin-5 is a microtubule polymerase
Yalei Chen, William O. Hancock, 2015, Nature Communications
The Kinesin-1 Chemomechanical Cycle: Stepping Toward a Consensus
William O. Hancock, 2016, Biophysical Journal on p. 1216-1225
Transport by populations of fast and slow kinesins uncovers novel family-dependent motor characteristics important for in vivo function
Göker Arpaʇ, Shankar Shastry, William O. Hancock, Erkan Tüzel, 2014, Biophysical Journal on p. 1896-1904
The mechanochemical cycle of mammalian kinesin-2 KIF3A/B under load
Johan O.L. Andreasson, Shankar Shastry, William O. Hancock, Steven M. Block, 2015, Current Biology on p. 1166-1175
Kinesin's neck-linker determines its ability to navigate obstacles on the microtubule surface
Gregory J. Hoeprich, Andrew R. Thompson, Derrick P. McVicker, William O. Hancock, Christopher L. Berger, 2014, Biophysical Journal on p. 1691-1700
Molecular counting by photobleaching in protein complexes with many subunits: Best practices and application to the cellulose synthesis complex
Yalei Chen, Nathan C. Deffenbaugh, Charles T. Anderson, William O. Hancock, 2014, Molecular Biology of the Cell on p. 3630-3642
News Articles Featuring William Hancock
Apr 11, 2023
Study on how neurons move offers new insight into neurodegenerative diseases
Neurons, which are responsible for producing the signals that ultimately trigger an action like talking or moving a muscle, are built and maintained by classes of motor proteins that transport molecular cargo along elongated tracks called microtubules.
Full Article
Apr 11, 2019
New SCATTIRSTORM microscope could improve bioenergy production
The construction of a new multimodal optical microscope, SCATTIRSTORM, that could enable more efficient bioenergy production, is the focus of a three-year, $1.5 million, U.S. Department of Energy grant awarded to three Penn State researchers.
Full Article