Wendy Hanna-Rose
Professor of Biochemistry and Molecular Biology; Head of BMB
-
Huck Life Sciences
University Park, - She/Her
- wxh21@psu.edu
- 814-865-7904
Research Summary
Molecular Genetics of Metabolism and Development in C. elegans
Huck Affiliations
Links
Most Recent Publications
Adenosine deaminase and deoxyadenosine regulate intracellular immune response in C. elegans
Nicole D. Wernet, Eillen Tecle, Mario Bardan Sarmiento, Cheng Ju Kuo, Crystal B. Chhan, Ian Baick, Lakshmi E. Batachari, Latisha Franklin, Alice Herneisen, Gira Bhabha, Damian C. Ekiert, Wendy Hanna-Rose, Emily R. Troemel, 2025, iScience
Current insights in ultra-rare adenylosuccinate synthetase 1 myopathy – meeting report on the First Clinical and Scientific Conference. 3 June 2024, National Centre for Advancing Translational Science, Rockville, Maryland, the United States of America
Emma Rybalka, Hyung Jun Park, Atchayaram Nalini, Dipti Baskar, Kiran Polavarapu, Hacer Durmus, Yang Xia, Linlin Wan, Perry B. Shieh, Behzad Moghadaszadeh, Alan H. Beggs, David L. Mack, Alec S.T. Smith, Wendy Hanna-Rose, Hyder A. Jinnah, Cara A. Timpani, Min Shen, Jaymin Upadhyay, Jeffrey J. Brault, Matthew D. Hall, Naveen Baweja, Priyanka Kakkar, 2024, Orphanet Journal of Rare Diseases
A Caenorhabditis elegans model of adenylosuccinate lyase deficiency reveals neuromuscular and reproductive phenotypes of distinct etiology
A Fenton, H Janowitz, L Franklin, R Young, C Moro, M DeGennaro, Melanie R. McReynolds, W Wang, Wendy Hanna-Rose, 2023, Biochemical Medicine and Metabolic Biology on p. 107686
Adenylosuccinate lyase deficiency affects neurobehavior via perturbations to tyramine signaling in Caenorhabditis elegans
Corinna A. Moro, Sabrina A. Sony, Latisha P. Franklin, Shirley Dong, Mia M. Peifer, Kathryn E. Wittig, Wendy Hanna-Rose, 2023, PLoS Genetics
Erratum: The purine nucleoside phosphorylase pnp-1 regulates epithelial cell resistance to infection in C. elegans (PLoS Pathogens (2021) 17:4 (e1009350) DOI: 10.1371/journal.ppat.1009350)
Eillen Tecle, Crystal B. Chhan, Latisha Franklin, Ryan S. Underwood, Wendy Hanna-Rose, Emily R. Troemel, 2022, PLoS Pathogens
Noncanonical necrosis in 2 different cell types in a Caenorhabditis elegans NAD1 salvage pathway mutant
Rifath N. Reza, Nicholas D. Serra, Ariana C. Detwiler, Wendy Hanna-Rose, Matt Crook, 2022, G3: Genes, Genomes, Genetics
Overactive EGF signaling suppresses a C. elegans pnc-1 egg-laying phenotype independent of known signaling mediators.
M Crook, Wendy Hanna-Rose, 2021, microPublication biology
The purine nucleoside phosphorylase pnp-1 regulates epithelial cell resistance to infection in C. elegans
E Tecle, C Chhan, L Franklin, R Underwood, Wendy Hanna-Rose, E Troemel, 2021, PLoS Pathogens on p. e1009350
Overactive EGF signaling promotes uv1 cell survival <i>via</i> increased phosphatidylcholine levels and suppression of SBP-1.
M Crook, Wendy Hanna-Rose, 2020, microPublication biology
Animal Model Contributions to Congenital Metabolic Disease
Corinna A. Moro, Wendy Hanna-Rose, 2020, on p. 225-244
Most-Cited Papers
Rotational manipulation of single cells and organisms using acoustic waves
Daniel Ahmed, Adem Ozcelik, Nagagireesh Bojanala, Nitesh Nama, Awani Upadhyay, Yuchao Chen, Wendy Hanna-Rose, Tony Jun Huang, 2016, Nature Communications
Acoustofluidic Rotational Manipulation of Cells and Organisms Using Oscillating Solid Structures
Adem Ozcelik, Nitesh Nama, Po-Hsun Huang, Murat Kaynak, Melanie McReynolds, Wendy Hanna-Rose, Tony Huang, 2016, Small on p. 5120-5125
The purine nucleoside phosphorylase pnp-1 regulates epithelial cell resistance to infection in C. elegans
E Tecle, C Chhan, L Franklin, R Underwood, Wendy Hanna-Rose, E Troemel, 2021, PLoS Pathogens on p. e1009350
Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel
Awani Upadhyay, Aditya Pisupati, Timothy Jegla, Matt Crook, Keith J. Mickolajczyk, Matthew Shorey, Laura E. Rohan, Katherine A. Billings, Melissa M. Rolls, William O. Hancock, Wendy Hanna-Rose, 2016, Nature Communications
Comparative metabolomic profiling reveals that dysregulated glycolysis stemming from lack of salvage NAD<sup>+</sup> biosynthesis impairs reproductive development in Caenorhabditis elegans
Wenqing Wang, Melanie McReynolds, Jimmy Goncalves, Muya Shu, Ineke Dhondt, Bart Braeckman, Stephanie Lange, Kelvin Kho, Ariana Detwiler, Marisa Pacella, Wendy Hanna-Rose, 2015, Journal of Biological Chemistry on p. 26163-26179
Zinc deficiency reduces fertility in C. elegans hermaphrodites and disrupts oogenesis and meiotic progression
James Hester, Wendy Hanna-Rose, Francisco Diaz, 2017, Comparative Biochemistry and Physiology - C Toxicology and Pharmacology on p. 203-209
Animal Model Contributions to Congenital Metabolic Disease
Corinna A. Moro, Wendy Hanna-Rose, 2020, on p. 225-244
Uridine monophosphate synthetase enables eukaryotic de novo NAD<sup>+</sup> biosynthesis from quinolinic acid
Melanie McReynolds, Wenqing Wang, Lauren Holleran, Wendy Hanna-Rose, 2017, Journal of Biological Chemistry on p. 11147-11153
Acoustofluidics: Acoustofluidic Rotational Manipulation of Cells and Organisms Using Oscillating Solid Structures (Small 37/2016)
Adem Ozcelik, Nitesh Nama, Po Hsun Huang, Murat Kaynak, Melanie R. McReynolds, Wendy Hanna-Rose, Tony Jun Huang, 2016, Small on p. 5230
Nicotinamide Inhibits Aphid Fecundity and Impacts Survival
Sampurna Sattar, M Martinez, A Ruiz, Wendy Hanna-Rose, G Thompson, 2019, Scientific Reports on p. 19709
News Articles Featuring Wendy Hanna-Rose
Mar 07, 2024
Undergraduate Exhibition helps students prepare for future research
The 2024 Undergraduate Exhibition for Research, Inquiry and Creative Activity will once again showcase a diverse range of student presentations with an in-person portion from 11 a.m. to 1 p.m. April 17 and a virtual exhibition from April 15-17.
Full Article
Jul 18, 2023
Two honored with Eberly Distinguished Faculty Mentoring Award
Two members of the Eberly College of Science have been selected to receive the college's Distinguished Faculty Mentoring Award in 2023.
Full Article
Feb 23, 2023
Nobel Prize-winning Penn State alumnus Paul Berg dies
Penn State alumnus Paul Berg, who received the 1980 Nobel Prize in chemistry, died Feb. 15 at his home in Stanford, California, surrounded by loved ones. He was 96.
Full Article
Nov 09, 2022
Schlegels endow Early Career Professorship in biochemistry and molecular biology
Retired Pen State faculty Robert “Bob” and Peggy Schlegel couldn’t afford to hire a cleaning service and caterer every time a new faculty job candidate came to town.
Full Article