Wansheng Liu
Professor of Genomics
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Wm Henning Bldg
University Park, - wul12@psu.edu
- 814-867-1673
Research Summary
Functional annotation of farm animal genomes, structure and function of mammalian sex (X and Y) chromosome, spermatogenesis and male fertility.
Huck Affiliations
Most Recent Publications
Epigenomic Regulation of Gene Transcription across Tissues at Different Developmental Stages.
Huaijun Zhou, Wansheng Liu, PAG XXXI, January 12-17, 2024, San Diego, CA.
PRAMEY enhances sperm-egg binding and modulates epigenetic dynamics in bovine embryogenesis
Wansheng Liu, Chandlar Kern, PAG XXXII, January 10-15, 2025, San Diego, CA. PE0181.
PRAMEY- a sperm-carried protein that influences paternal DNA methylation in zygotes
Chandlar Kern, Wansheng Liu, 56th Annual SSR Meeting, Ottawa, Canada.
Integrative Annotation of the Bovine Genome
Dailu Guan, Wansheng Liu, PAG XXXI, January 12-17, 2024, San Diego, CA. PO0461.
Differentially Expressed Genes during Different Developmental Stages of Testis in Cattle.
Wansheng Liu, Waqar Bahtti, PAG XXXI, January 12-17, 2024, San Diego, CA. PE0464
The Farm Animal Genotype–Tissue Expression (FarmGTEx) Project
Wansheng Liu, 2025, Nature Genetics
Sex chromosome-linked prame genes in gametogenesis, fertilization, and embryogenesis
Wansheng Liu, 2025, PAG XXXII, January 10-15, 2025, San Diego, CA. Abstract id# 58536.
Transcriptome dynamics and gene regulatory networks during testis development and spermatogenesis in cattle
Wansheng Liu, T Kim, 2025, USDA-NIFA, Animal Genetics and Genomics Program PD meeting, January 10, 2025, San Diego, CA.
Synergistic enhancement of the mouse Pramex1 and Pramel1 in repressing retinoic acid (RA) signaling during gametogenesis
M Yang, Francisco Diaz, Krause ART, Ana Rita T. Krause, Yuguo Lei, Wan Sheng Liu, 2024, Cell and Bioscience on p. 28
Enhanced bovine genome annotation through integration of transcriptomics and epi-transcriptomics datasets facilitates genomic biology
Hamid Beiki, Brenda M. Murdoch, Carissa A. Park, Chandlar Kern, Denise Kontechy, Gabrielle Becker, Gonzalo Rincon, Honglin Jiang, Huaijun Zhou, Jacob Thorne, James E. Koltes, Jennifer J. Michal, Kimberly Davenport, Monique Rijnkels, Pablo J. Ross, Rui Hu, Sarah Corum, Stephanie McKay, Timothy P.L. Smith, Wansheng Liu, Wenzhi Ma, Xiaohui Zhang, Xiaoqing Xu, Xuelei Han, Zhihua Jiang, Zhi Liang Hu, James M. Reecy, 2024, GigaScience
Most-Cited Papers
MicroRNA in ovarian function
S. W. Maalouf, W. S. Liu, J. L. Pate, 2016, Cell and Tissue Research on p. 7-18
Superconductivity in the half-Heusler compound TbPdBi
H. Xiao, T. Hu, W. Liu, Y.L. Zhu, P.G. Li, G. Mu, J. Su, K. Li, Z.Q. Mao, 2018, Physical Review B-Condensed Matter
Early cleavage of preimplantation embryos is regulated by tRNA<sup>Gln-TTG</sup>-derived small RNAs present in mature spermatozoa
Xiaoxu Chen, Yi Zheng, Anmin Lei, Hanxue Zhang, Huimin Niu, Xueliang Li, Pengfei Zhang, Mingzhi Liao, Yinghua Lv, Zhendong Zhu, Chuanying Pan, Wuzi Dong, Hong Chen, De Wu, Wansheng Liu, Geert Hamer, Shenming Zeng, Wenxian Zeng, 2020, Journal of Biological Chemistry on p. 10885-10900
Mammalian Sex Chromosome Structure, Gene Content, and Function in Male Fertility
Wan Sheng Liu, 2019, Annual Review of Animal Biosciences on p. 103-124
The PRAME family of cancer testis antigens is essential for germline development and gametogenesis
Chandlar H. Kern, Mingyao Yang, Wan Sheng Liu, 2021, Biology of Reproduction on p. 290-304
A limited number of Y chromosome lineages is present in North American Holsteins
Xiang Peng Yue, Chad Dechow, Wan Sheng Liu, 2015, Journal of Dairy Science on p. 2738-2745
Molecular profiling demonstrates modulation of immune cell function and matrix remodeling during luteal rescue
Camilla K. Hughes, Samar W. Maalouf, Wansheng Liu, Joy L. Pate, 2019, Biology of Reproduction on p. 1581–1596
Reconstitution and modernization of lost Holstein male lineages using samples from a gene bank
C. D. Dechow, W. S. Liu, L Specht, H Blackburn, 2020, Journal of Dairy Science on p. 4510-4516
A novel testis-specific protein, PRAMEY, is involved in spermatogenesis in cattle
Wan Sheng Liu, Yaqi Zhao, Chen Lu, Gang Ning, Yun Ma, Francisco Diaz, Michael O'Connor, 2017, Reproduction on p. 847-863
DNA methylation patterns in peripheral blood mononuclear cells from Holstein cattle with variable milk yield
Chad D. Dechow, Wan Sheng Liu, 2018, BMC Genomics on p. 744
News Articles Featuring Wansheng Liu
Aug 01, 2024
Penn State researchers receive USDA-NIFA grant to study male cattle genetics
The U.S. Department of Agriculture (USDA) has awarded a grant to a team of researchers in the Penn State College of Agricultural Sciences to study the genetic mechanisms underlying the development of the testis, the male organ that produces reproductive cells, in cattle and its role in sperm production.
Full Article
Dec 07, 2023
USDA grant supports reproductive microbiome training program
The USDA NIFA has awarded Penn State a five-year, US$238,500 grant to establish a graduate training pipeline in reproductive microbiome research
Full Article
Dec 06, 2023
New USDA grant to support graduate reproductive microbiome training program
The USDA NIFA has awarded Penn State a five-year, $238,500 grant to establish a graduate training pipeline in reproductive microbiome research.
Full Article
Oct 23, 2023
Gene integral to initiating, sustaining sperm cell development identified
With male infertility a mounting global concern impacting approximately 12% of men, a Penn State research team has discovered a gene that plays a key role in initiating and sustaining spermatogenesis. The finding may open a door for future therapies to boost sperm counts.
Full Article