Wansheng Liu
Professor of Genomics

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Wm Henning Bldg
University Park, - wul12@psu.edu
- 814-867-1673
Research Summary
Functional annotation of farm animal genomes, structure and function of mammalian sex (X and Y) chromosome, spermatogenesis and male fertility.
Huck Affiliations
Publication Tags
Genes Cattle Rna Y Chromosome Melanoma Specific Antigens Testis Rna, Transfer, Gln Spermatogenesis Transfer Rna Micrornas Y Linked Genes Fertility Spermatozoa Antigens Breeds Germ Cells Ancestry Cleavage Holstein Blastocyst Sex Chromosomes Male Fertility Taurine Bulls Testicular NeoplasmsMost Recent Publications
The Dynamic of PRAMEY Isoforms in Testis and Epididymis Suggests Their Involvement in Spermatozoa Maturation
Chandlar H. Kern, Weber B. Feitosa, Wan Sheng Liu, 2022, Frontiers in Genetics
Subcellular localization of the mouse PRAMEL1 and PRAMEX1 reveals multifaceted roles in the nucleus and cytoplasm of germ cells during spermatogenesis
Wan Sheng Liu, Chen Lu, Bhavesh V. Mistry, 2021, Cell and Bioscience
The PRAME family of cancer testis antigens is essential for germline development and gametogenesis
Chandlar H. Kern, Mingyao Yang, Wan Sheng Liu, 2021, Biology of Reproduction on p. 290-304
Loss of Pramel1 disrupts the retinoic acid-mediated initiation of spermatogenesis
Mingyao Yang, Wansheng Liu, 2021, 36th Annual Graduate Exhibition 2021 and 5th Penn State Life Sciences Symposium 2021
Knockout of Pramel1 Impairs Germ Cell Development during Spermatogenesis in Mice through the Retinoic Acid (RA) Signaling Pathway
Mingyao Yang, Wansheng Liu, 2021, 54th Annual SSR Meeting, St. Louis, MO. Poster # 2947.
Additional annotation of bovine genome using integration of multi-omics data
Hamid Beiki, Wansheng Liu, 2021, 38th International Society for Animal Genetics (ISAG) Virtual Conference
Mammalian sex chromosome-linked cancer/testis antigens (CTAs) and male fertility
Wansheng Liu, 2021, European Society of Medicine (ESMED) Virtual Congress, Nov 11-13, 2021.
Highly efficient synchronization of sheep skin fibroblasts at G2/M phase and isolation of sheep Y chromosomes by flow cytometric sorting
Yanzhu Yao, Yuanyuan Zhang, Wansheng Liu, Xuemei Deng, 2020, Scientific Reports
Early cleavage of preimplantation embryos is regulated by tRNA<sup>Gln-TTG</sup>-derived small RNAs present in mature spermatozoa
Xiaoxu Chen, Yi Zheng, Anmin Lei, Hanxue Zhang, Huimin Niu, Xueliang Li, Pengfei Zhang, Mingzhi Liao, Yinghua Lv, Zhendong Zhu, Chuanying Pan, Wuzi Dong, Hong Chen, De Wu, Wansheng Liu, Geert Hamer, Shenming Zeng, Wenxian Zeng, 2020, Journal of Biological Chemistry on p. 10885-10900
Deletion of the mouse X-linked Prame gene causes germ cell reduction in spermatogenesis
Chen Lu, Mingyao Yang, Randall M. Rossi, Aihua Wang, Weber B. Feitosa, Francisco J. Diaz, Wan Sheng Liu, 2020, Molecular Reproduction and Development on p. 666-679
Most-Cited Papers
Worldwide Patterns of Ancestry, Divergence, and Admixture in Domesticated Cattle
Jared E. Decker, Stephanie D. McKay, Megan M. Rolf, Jae Woo Kim, Antonio Molina Alcalá, Tad S. Sonstegard, Olivier Hanotte, Anders Götherström, Christopher M. Seabury, Lisa Praharani, Masroor Ellahi Babar, Luciana Correia de Almeida Regitano, Mehmet Ali Yildiz, Michael P. Heaton, Wan Sheng Liu, Chu Zhao Lei, James M. Reecy, Muhammad Saif-Ur-Rehman, Robert D. Schnabel, Jeremy F. Taylor, 2014, PLoS Genetics
MicroRNA in ovarian function
S. W. Maalouf, W. S. Liu, J. L. Pate, 2016, Zeitschrift für Zellforschung und mikroskopische Anatomie (Vienna, Austria : 1948) on p. 7-18
Male-specific region of the bovine Y chromosome is gene rich with a high transcriptomic activity in testis development
Ti Cheng Chang, Yang Yang, Ernest F. Retzel, Wan Sheng Liu, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 12373-12378
Superconductivity in the half-Heusler compound TbPdBi
H. Xiao, T. Hu, W. Liu, Y.L. Zhu, P.G. Li, G. Mu, J. Su, K. Li, Z.Q. Mao, 2018, Physical Review B-Condensed Matter
Copy number variations of the extensively amplified Y-linked genes, HSFY and ZNF280BY, in cattle and their association with male reproductive traits in Holstein bulls
Xiang Peng Yue, Chad Dechow, Ti Cheng Chang, James M. DeJarnette, Clifton E. Marshall, Chu Zhao Lei, Wan Sheng Liu, 2014, BMC Genomics
Copy number variation of PRAMEY across breeds and its association with male fertility in Holstein sires
X. P. Yue, T. C. Chang, J. M. DeJarnette, C. E. Marshall, C. Z. Lei, W. S. Liu, 2013, Journal of Dairy Science on p. 8024-8034
Regulating life or death: Potential role of microRNA in rescue of the corpus luteum
Samar W. Maalouf, Wan Sheng Liu, Istvan Albert, Joy L. Pate, 2014, Molecular and Cellular Endocrinology on p. 78-88
Early cleavage of preimplantation embryos is regulated by tRNA<sup>Gln-TTG</sup>-derived small RNAs present in mature spermatozoa
Xiaoxu Chen, Yi Zheng, Anmin Lei, Hanxue Zhang, Huimin Niu, Xueliang Li, Pengfei Zhang, Mingzhi Liao, Yinghua Lv, Zhendong Zhu, Chuanying Pan, Wuzi Dong, Hong Chen, De Wu, Wansheng Liu, Geert Hamer, Shenming Zeng, Wenxian Zeng, 2020, Journal of Biological Chemistry on p. 10885-10900
Mammalian Sex Chromosome Structure, Gene Content, and Function in Male Fertility
Wan Sheng Liu, 2019, Annual Review of Animal Biosciences on p. 103-124
A limited number of Y chromosome lineages is present in North American Holsteins
Xiang Peng Yue, Chad Dechow, Wan Sheng Liu, 2015, Journal of Dairy Science on p. 2738-2745