Troy Sutton
Huck Early Career Chair in Virology, Associate Professor of Immunology and Infectious Disease
- He/Him
- tcs38@psu.edu
- tcs38@psu.edu
Research Summary
Animal models of influenza; Airborne transmission of influenza viruses; Evolution of pandemic influenza viruses; Highly pathogenic avian influenza; Development of live-attenuated influenza vaccine platforms; High containment BSL3+ research
Huck Affiliations
Most Recent Publications
Risk assessment of a highly pathogenic H5N1 influenza virus from mink
Katherine H. Restori, Kayla M. Septer, Cassandra J. Field, Devanshi R. Patel, David VanInsberghe, Vedhika Raghunathan, Anice C. Lowen, Troy C. Sutton, 2024, Nature Communications
Intranasal SARS-CoV-2 RBD decorated nanoparticle vaccine enhances viral clearance in the Syrian hamster model.
D Patel, A Minns, D Sim, C Field, A Kerr, T Heinly, E Luley, R Rossi, C Bator, I Moustafa, E Norton, S Hafenstein, S Lindner, Troy Sutton, 2024, Microbiology spectrum on p. e0499822
Intranasal SARS-CoV-2 RBD decorated nanoparticle vaccine enhances viral clearance in the Syrian hamster model
Devanshi R. Patel, Allen M. Minns, Derek G. Sim, Cassandra J. Field, Abigail E. Kerr, Talia A. Heinly, Erin H. Luley, Randall M. Rossi, Carol M. Bator, Ibrahim M. Moustafa, Elizabeth B. Norton, Susan L. Hafenstein, Scott E. Lindner, Troy C. Sutton, 2024, Microbiology spectrum
Characterization of Mutations Enriched During Sequential Transmission of H7N9 Influenza Virus in Ferrets
Troy Sutton, 2023, Proceedings of NIAID Centers of Excellence for Influenza Research and Response 2nd Annual Conference
Neuraminidase immunity decreases viral shedding, but does not disrupt chains of airborne transmission for 2009 pandemic H1N1 in the ferret model.
Troy Sutton, 2023, Proceedings of NIAID Centers of Excellence for Influenza Research and Response 2nd Annual Conference
Virology under the Microscope—a Call for Rational Discourse
F Goodrum, A Lowen, S Lakdawala, J Alwine, A Casadevall, M Imperiale, W Atwood, D Avgousti, J Baines, B Banfield, L Banks, S Bhaduri-McIntosh, D Bhattacharya, D Blanco-Melo, D Bloom, A Boon, S Boulant, C Brandt, A Broadbent, C Brooke, C Cameron, S Campos, P Caposio, G Chan, A Cliffe, J Coffin, K Collins, B Damania, M Daugherty, K Debbink, J DeCaprio, T Dermody, J Dikeakos, D DiMaio, R Dinglasan, W Duprex, R Dutch, N Elde, M Emerman, L Enquist, B Fane, A Fernandez-Sesma, M Flenniken, L Frappier, M Frieman, K Frueh, M Gack, M Gaglia, T Gallagher, D Galloway, A García-Sastre, A Geballe, B Glaunsinger, S Goff, A Greninger, M Hancock, E Harris, N Heaton, M Heise, E Heldwein, B Hogue, S Horner, E Hutchinson, J Hyser, W Jackson, R Kalejta, J Kamil, S Karst, F Kirchhoff, D Knipe, T Kowalik, M Lagunoff, L Laimins, R Langlois, A Lauring, B Lee, D Leib, S Liu, R Longnecker, C Lopez, M Luftig, J Lund, B Manicassamy, G McFadden, M McIntosh, A Mehle, W Miller, I Mohr, C Moody, N Moorman, A Moscona, B Mounce, J Munger, K Münger, E Murphy, M Naghavi, J Nelson, C Neufeldt, J Nikolich, C O'Connor, A Ono, W Orenstein, D Ornelles, J Ou, J Parker, C Parrish, A Pekosz, P Pellett, J Pfeiffer, R Plemper, S Polyak, J Purdy, D Pyeon, M Quinones-Mateu, R Renne, C Rice, J Schoggins, R Roller, C Russell, R Sandri-Goldin, M Sapp, L Schang, S Schmid, S Schultz-Cherry, B Semler, T Shenk, G Silvestri, V Simon, G Smith, J Smith, K Spindler, M Stanifer, K Subbarao, W Sundquist, M Suthar, Troy Sutton, A Tai, V Tarakanova, B tenOever, S Tibbetts, S Tompkins, Z Toth, K van Doorslaer, M Vignuzzi, N Wallace, D Walsh, M Weekes, J Weinberg, M Weitzman, S Weller, S Whelan, E White, B Williams, C Wobus, S Wong, A Yurochko, 2023, Journal of Virology on p. e0008923
Virology under the Microscope—a Call for Rational Discourse
F Goodrum, A Lowen, S Lakdawala, J Alwine, A Casadevall, M Imperiale, W Atwood, D Avgousti, J Baines, B Banfield, L Banks, S Bhaduri-McIntosh, D Bhattacharya, D Blanco-Melo, D Bloom, A Boon, S Boulant, C Brandt, A Broadbent, C Brooke, C Cameron, S Campos, P Caposio, G Chan, A Cliffe, J Coffin, K Collins, B Damania, M Daugherty, K Debbink, J DeCaprio, T Dermody, J Dikeakos, D DiMaio, R Dinglasan, W Duprex, R Dutch, N Elde, M Emerman, L Enquist, B Fane, A Fernandez-Sesma, M Flenniken, L Frappier, M Frieman, K Frueh, M Gack, M Gaglia, T Gallagher, D Galloway, A García-Sastre, A Geballe, B Glaunsinger, S Goff, A Greninger, M Hancock, E Harris, N Heaton, M Heise, E Heldwein, B Hogue, S Horner, E Hutchinson, J Hyser, W Jackson, R Kalejta, J Kamil, S Karst, F Kirchhoff, D Knipe, T Kowalik, M Lagunoff, L Laimins, R Langlois, A Lauring, B Lee, D Leib, S Liu, R Longnecker, C Lopez, M Luftig, J Lund, B Manicassamy, G McFadden, M McIntosh, A Mehle, W Miller, I Mohr, C Moody, N Moorman, A Moscona, B Mounce, J Munger, K Münger, E Murphy, M Naghavi, J Nelson, C Neufeldt, J Nikolich, C O'Connor, A Ono, W Orenstein, D Ornelles, J Ou, J Parker, C Parrish, A Pekosz, P Pellett, J Pfeiffer, R Plemper, S Polyak, J Purdy, D Pyeon, M Quinones-Mateu, R Renne, C Rice, J Schoggins, R Roller, C Russell, R Sandri-Goldin, M Sapp, L Schang, S Schmid, S Schultz-Cherry, B Semler, T Shenk, G Silvestri, V Simon, G Smith, J Smith, K Spindler, M Stanifer, K Subbarao, W Sundquist, M Suthar, Troy Sutton, A Tai, V Tarakanova, B tenOever, S Tibbetts, S Tompkins, Z Toth, K van Doorslaer, M Vignuzzi, N Wallace, D Walsh, M Weekes, J Weinberg, M Weitzman, S Weller, S Whelan, E White, B Williams, C Wobus, S Wong, A Yurochko, 2023, mSphere on p. e0003423
Virology under the Microscope-a Call for Rational Discourse
F Goodrum, A Lowen, S Lakdawala, J Alwine, A Casadevall, M Imperiale, W Atwood, D Avgousti, J Baines, B Banfield, L Banks, S Bhaduri-McIntosh, D Bhattacharya, D Blanco-Melo, D Bloom, A Boon, S Boulant, C Brandt, A Broadbent, C Brooke, C Cameron, S Campos, P Caposio, G Chan, A Cliffe, J Coffin, K Collins, B Damania, M Daugherty, K Debbink, J DeCaprio, T Dermody, J Dikeakos, D DiMaio, R Dinglasan, W Duprex, R Dutch, N Elde, M Emerman, L Enquist, B Fane, A Fernandez-Sesma, M Flenniken, L Frappier, M Frieman, K Frueh, M Gack, M Gaglia, T Gallagher, D Galloway, A García-Sastre, A Geballe, B Glaunsinger, S Goff, A Greninger, M Hancock, E Harris, N Heaton, M Heise, E Heldwein, B Hogue, S Horner, E Hutchinson, J Hyser, W Jackson, R Kalejta, J Kamil, S Karst, F Kirchhoff, D Knipe, T Kowalik, M Lagunoff, L Laimins, R Langlois, A Lauring, B Lee, D Leib, S Liu, R Longnecker, C Lopez, M Luftig, J Lund, B Manicassamy, G McFadden, M McIntosh, A Mehle, W Miller, I Mohr, C Moody, N Moorman, A Moscona, B Mounce, J Munger, K Münger, E Murphy, M Naghavi, J Nelson, C Neufeldt, J Nikolich, C O'Connor, A Ono, W Orenstein, D Ornelles, J Ou, J Parker, C Parrish, A Pekosz, P Pellett, J Pfeiffer, R Plemper, S Polyak, J Purdy, D Pyeon, M Quinones-Mateu, R Renne, C Rice, J Schoggins, R Roller, C Russell, R Sandri-Goldin, M Sapp, L Schang, S Schmid, S Schultz-Cherry, B Semler, T Shenk, G Silvestri, V Simon, G Smith, J Smith, K Spindler, M Stanifer, K Subbarao, W Sundquist, M Suthar, Troy Sutton, A Tai, V Tarakanova, B tenOever, S Tibbetts, S Tompkins, Z Toth, K van Doorslaer, M Vignuzzi, N Wallace, D Walsh, M Weekes, J Weinberg, M Weitzman, S Weller, S Whelan, E White, B Williams, C Wobus, S Wong, A Yurochko, 2023, mBio on p. e0018823
Sequential Transmission of Influenza Viruses in Ferrets Does Not Enhance Infectivity and Does Not Predict Transmissibility in Humans
Troy C. Sutton, Elaine W. Lamirande, Devanshi R. Patel, Katherine E.E. Johnson, Rita Czako, Elodie Ghedin, Raphael T.C. Lee, Sebastian Maurer-Stroh, Kanta Subbarao, 2022, mBio
Transmission of Human Influenza A Virus in Pigs Selects for Adaptive Mutations on the HA Gene
Jong Suk Mo, Eugenio J. Abente, Matias Cardenas Perez, Troy C. Sutton, Brianna Cowan, Lucas M. Ferreri, Ginger Geiger, Phillip C. Gauger, Daniel R. Perez, Amy L. Vincent Baker, Daniela S. Rajao, 2022, Journal of Virology
Most-Cited Papers
The pandemic threat of emerging H5 and H7 avian influenza viruses
Troy C. Sutton, 2018, Viruses
Novel reassortant human-like H3N2 and H3N1 influenza A viruses detected in pigs are virulent and antigenically distinct from swine viruses endemic to the United States
D Rajão, P Gauger, T Anderson, N Lewis, E Abente, M Killian, D Perez, Troy Sutton, J Zhang, A Vincent, 2015, Journal of Virology on p. 11213-11222
Development of animal models against emerging coronaviruses: From SARS to MERS coronavirus
Troy C. Sutton, Kanta Subbarao, 2015, Virology on p. 247-258
Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibody
Katherine V. Houser, Andrew J. Broadbent, Lisa Gretebeck, Leatrice Vogel, Elaine W. Lamirande, Troy Sutton, Kevin W. Bock, Mahnaz Minai, Marlene Orandle, Ian N. Moore, Kanta Subbarao, 2017, PLoS Pathogens
Airborne transmission of highly pathogenic H7N1 influenza virus in ferrets
Troy C. Sutton, Courtney Finch, Hongxia Shao, Matthew Angel, Hongjun Chen, Ilaria Capua, Giovanni Cattoli, Isabella Monne, Daniel R. Pereza, 2014, Journal of Virology on p. 6623-6635
Protective efficacy of influenza group 2 hemagglutinin stem-fragment immunogen vaccines
Troy C. Sutton, Saborni Chakraborty, Vamsee V.A. Mallajosyula, Elaine W. Lamirande, Ketaki Ganti, Kevin W. Bock, Ian N. Moore, Raghavan Varadarajan, Kanta Subbarao, 2017, npj Vaccines
Interactions between the influenza A virus RNA polymerase components and retinoic acid-inducible gene I
Weizhong Li, Hongjun Chen, Troy Sutton, Adebimpe Obadan, Daniel R. Perez, 2014, Journal of Virology on p. 10432-10447
Alternative reassortment events leading to transmissible h9n1 influenza viruses in the ferret model
Brian J. Kimble, Matthew Angel, Hongquan Wan, Troy C. Sutton, Courtney Finch, Daniel R. Perez, 2014, Journal of Virology on p. 66-71
In vitro neutralization is not predictive of prophylactic efficacy of broadly neutralizing monoclonal antibodies CR6261 and CR9114 against lethal H2 influenza virus challenge in mice
Troy C. Sutton, Elaine W. Lamirande, Kevin W. Bock, Ian N. Moore, Wouter Koudstaal, Muniza Rehman, Gerrit Jan Weverling, Jaap Goudsmit, Kanta Subbarao, 2017, Journal of Virology
Transmission and protection against reinfection in the ferret model with the SARS-CoV-2 USA-WA1/2020 reference isolate
Devanshi Patel, Cassandra Field, Kayla Septer, Derek G. Sim, Matthew J. Jones, T Heinly, Thomas Vanderford, Elizabeth A. McGraw, Troy Sutton, 2021, Journal of Virology on p. e0223220
News Articles Featuring Troy Sutton
Oct 30, 2024
1st US case of bird flu in a pig raises concerns over potential human threat
A pig at an Oregon farm was found to have bird flu, the U.S. Department of Agriculture announced Wednesday. It's the first time the virus has been detected in U.S. swine and raises concerns about bird flu's potential to become a human threat.
Full Article
Aug 21, 2024
How U.S. Farms Could Start a Bird Flu Pandemic
The virus is poised to become a permanent presence in cattle, raising the odds of an eventual outbreak among people.
Full Article
Aug 06, 2024
I’m About to Go on a Big Trip. Should I Be Worried About Bird Flu?
I'm planning to climb a bunch of fourteeners in Colorado, but bird flu is all over the state right now—is it safe for me to go?
Full Article
Jul 24, 2024
With the U.S. bird flu outbreak uncontained, scientists see growing risks
For nearly four months, the spread of bird flu in the nation’s dairy cattle has stoked fears that, if left unchecked, the virus could eventually unleash a pandemic.
Full Article
Jul 19, 2024
Troy Sutton named Huck Early Career Chair in Virology
Troy Sutton, assistant professor of veterinary and biomedical sciences in the College of Agricultural Sciences at Penn State, has been awarded a Dorothy Foehr Huck and J. Lloyd Huck Early Career Chair in Virology.
Full Article
Jun 06, 2024
What to know about the first human case of H5N2 bird flu
H5N2, which was confirmed in a man in Mexico who died, is just one of several kinds of avian influenza viruses. It’s deadly for poultry, but does it pose a significant risk to humans?
Full Article
May 16, 2024
H5N1 virus from 2022 mink outbreak capable of inefficient airborne transmission
Highly pathogenic H5N1 avian influenza was detected in dairy cattle for the first time in the United States in March, with nine states reporting outbreaks by May. While the method of transmission among cattle is currently unknown, new research demonstrates that a related strain of H5N1, which caused an outbreak in farmed mink in 2022, could transmit through the air to a limited number of ferrets.
Full Article
Apr 24, 2024
Dairy Cows Transported Between States Must Now Be Tested for Bird Flu
Since a new form of bird flu arrived in 2022, federal officials have sought to reassure Americans that the threat to the public remained low.
Full Article
Apr 22, 2024
Bird Flu Is Infecting More Mammals. What Does That Mean for Us?
H5N1, an avian flu virus, has killed tens of thousands of marine mammals, and infiltrated American livestock for the first time. Scientists are working quickly to assess how it is evolving and how much of a risk it poses to humans.
Full Article
Mar 12, 2024
New nasal vaccine platform helps clear COVID-19 infections in an animal model
A newly developed intranasal vaccine candidate helps to clear COVID-19 infections more quickly than controls in pre-clinical testing, according to a recent study.
Full Article
Jul 23, 2022
I study coronavirus in a highly secured biosafety lab – here's why I feel safer here than in the world outside
As I dilute the coronavirus to infect cultured cells, I hear the reassuring sound of purified air being blown by my respirator into my breathing space. There are three layers of nitrile and protective materials between me and the virus, and every part of my body is wrapped in protective equipment.
Full Article
Apr 29, 2022
Contagious Bird Flu Presents Low Risk to People After Colorado Case
Avian influenza has killed millions of birds in U.S. and infected one known person
Full Article
Oct 21, 2021
Preparing for potential pandemics is focus of new federal grant to Penn State
Researchers at Penn State have received a grant from the National Institute of Allergy and Infectious Diseases to study H7N9 with a goal of developing new and fundamental knowledge of virus mutations that could indicate the potential for transmissibility in humans.
Full Article
Jun 22, 2020
This supersafe labs protects researchers as they race to develop a coronavirus vaccine
It's quiet in the laboratory, almost peaceful. But I'm holding live SARS-CoV-2 in my hands and this virus is not to be taken lightly.
Full Article
Nov 05, 2024
Inside a High-Security Virus Lab
Inside the second-most secure type of biosafety lab in the U.S. at Penn State
Full Article