Troy Sutton
Assistant Professor of Veterinary and Biomedical Sciences

- He/Him
- tcs38@psu.edu
- tcs38@psu.edu
Research Summary
Animal models of influenza; Airborne transmission of influenza viruses; Evolution of pandemic influenza viruses; Highly pathogenic avian influenza; Development of live-attenuated influenza vaccine platforms; High containment BSL3+ research
Huck Affiliations
Publication Tags
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Influenza A Virus Human Influenza Viruses Orthomyxoviridae Swine Genes Ferrets Pandemics Hemagglutinins Orthomyxoviridae Infections Animal Disease Models Animals Rna Influenza In Birds Mutation Virus Replication Viral Antibodies H9n2 Subtype Influenza A Virus Pandemic Proteins Infections Genome Infection H5n1 Subtype Influenza A Virus MammalsMost Recent Publications
Virology under the Microscope-a Call for Rational Discourse.
F Goodrum, A Lowen, S Lakdawala, J Alwine, A Casadevall, M Imperiale, W Atwood, D Avgousti, J Baines, B Banfield, L Banks, S Bhaduri-McIntosh, D Bhattacharya, D Blanco-Melo, D Bloom, A Boon, S Boulant, C Brandt, A Broadbent, C Brooke, C Cameron, S Campos, P Caposio, G Chan, A Cliffe, J Coffin, K Collins, B Damania, M Daugherty, K Debbink, J DeCaprio, T Dermody, J Dikeakos, D DiMaio, R Dinglasan, W Duprex, R Dutch, N Elde, M Emerman, L Enquist, B Fane, A Fernandez-Sesma, M Flenniken, L Frappier, M Frieman, K Frueh, M Gack, M Gaglia, T Gallagher, D Galloway, A García-Sastre, A Geballe, B Glaunsinger, S Goff, A Greninger, M Hancock, E Harris, N Heaton, M Heise, E Heldwein, B Hogue, S Horner, E Hutchinson, J Hyser, W Jackson, R Kalejta, J Kamil, S Karst, F Kirchhoff, D Knipe, T Kowalik, M Lagunoff, L Laimins, R Langlois, A Lauring, B Lee, D Leib, S Liu, R Longnecker, C Lopez, M Luftig, J Lund, B Manicassamy, G McFadden, M McIntosh, A Mehle, W Miller, I Mohr, C Moody, N Moorman, A Moscona, B Mounce, J Munger, K Münger, E Murphy, M Naghavi, J Nelson, C Neufeldt, J Nikolich, C O'Connor, A Ono, W Orenstein, D Ornelles, J Ou, J Parker, C Parrish, A Pekosz, P Pellett, J Pfeiffer, R Plemper, S Polyak, J Purdy, D Pyeon, M Quinones-Mateu, R Renne, C Rice, J Schoggins, R Roller, C Russell, R Sandri-Goldin, M Sapp, L Schang, S Schmid, S Schultz-Cherry, B Semler, T Shenk, G Silvestri, V Simon, G Smith, J Smith, K Spindler, M Stanifer, K Subbarao, W Sundquist, M Suthar, Troy Sutton, A Tai, V Tarakanova, B tenOever, S Tibbetts, S Tompkins, Z Toth, K van Doorslaer, M Vignuzzi, N Wallace, D Walsh, M Weekes, J Weinberg, M Weitzman, S Weller, S Whelan, E White, B Williams, C Wobus, S Wong, A Yurochko, 2023, Journal of virology on p. e0008923
Sequential Transmission of Influenza Viruses in Ferrets Does Not Enhance Infectivity and Does Not Predict Transmissibility in Humans
Troy C. Sutton, Elaine W. Lamirande, Devanshi R. Patel, Katherine E.E. Johnson, Rita Czako, Elodie Ghedin, Raphael T.C. Lee, Sebastian Maurer-Stroh, Kanta Subbarao, 2022, mBio
Intranasal SARS-CoV-2 RBD decorated nanoparticle vaccine enhances viral clearance in the Syrian hamster model.
D Patel, Ibrahim Moustafa, A Minns, D Sims, C Field, A Kerr, T Heinly, E Luley, R Rossi, C Bator, I Mostafa, Susan Hafenstein, S Lindner, Troy Sutton, 2022, bioRxiv : the preprint server for biology
Transmission of Human Influenza A Virus in Pigs Selects for Adaptive Mutations on the HA Gene
Jong Suk Mo, Eugenio J. Abente, Matias Cardenas Perez, Troy C. Sutton, Brianna Cowan, Lucas M. Ferreri, Ginger Geiger, Phillip C. Gauger, Daniel R. Perez, Amy L. Vincent Baker, Daniela S. Rajao, 2022, Journal of Virology
Changes in the Hemagglutinin and Internal Gene Segments Were Needed for Human Seasonal H3 Influenza A Virus to Efficiently Infect and Replicate in Swine
Daniela S. Rajao, Eugenio J. Abente, Joshua D. Powell, Marcus J. Bolton, Phillip C. Gauger, Bailey Arruda, Tavis K. Anderson, Troy C. Sutton, Daniel R. Perez, Amy L. Vincent Baker, 2022, Pathogens
Immune durability and protection against SARS-CoV-2 re-infection in Syrian hamsters.
Cassandra Field, Talia Heinly, Devanshi Patel, D Sim, Erin Luley, S Gupta, Thomas Vanderford, Jens Wrammert, Troy Sutton, 2022,
The role of vaccine-induced intranasal immunity on transmission of pandemic H1N1 in the ferret model.
Kayla Septer, D Sim, Devanshi Patel, Cassandra Field, Talia Heinly, Elizabeth Norton, Troy Sutton, 2022,
Defining the relationship between inoculation dose and transmission for the 2009 H1N1 and 1968 H3N2 pandemic influenza viruses
Kayla Septer, Cassandra Field, Devanshi Patel, D Sim, Troy Sutton, 2022,
Aerosolized Hydrogen Peroxide Decontamination of N95 Respirators, with Fit-Testing and Viral Inactivation, Demonstrates Feasibility for Reuse during the COVID-19 Pandemic
Thomas Derr, Melissa James, Chad Kuny, Devanshi Patel, Prem Kendell, Prem Kandel, Cassandra Field, Matthew Beckman, Kevin L. Hockett, Mark Bates, Troy Sutton, Moriah L. Szpara, 2022, mSphere on p. e00303-22
Robustness of the Ferret Model for Influenza Risk Assessment Studies: a Cross-Laboratory Exercise
Jessica A. Belser, Eric H.Y. Lau, Wendy Barclay, Ian G. Barr, Hualan Chen, Ron A.M. Fouchier, Masato Hatta, Sander Herfst, Yoshihiro Kawaoka, Seema S. Lakdawala, Leo Yi Yang Lee, Gabriele Neumann, Malik Peiris, Daniel R. Perez, Charles Russell, Kanta Subbarao, Troy C. Sutton, Richard J. Webby, Huanliang Yang, Hui Ling Yen, 2022, mBio
Most-Cited Papers
The pandemic threat of emerging H5 and H7 avian influenza viruses
Troy C. Sutton, 2018, Viruses
MicroRNA-based strategy to mitigate the risk of gain-of-function influenza studies
Ryan A. Langlois, Randy A. Albrecht, Brian Kimble, Troy Sutton, Jillian S. Shapiro, Courtney Finch, Matthew Angel, Mark A. Chua, Ana Silvia Gonzalez-Reiche, Kemin Xu, Daniel Perez, Adolfo García-Sastre, Benjamin R. Tenoever, 2013, Nature Biotechnology on p. 844-847
Novel reassortant human-like H3N2 and H3N1 influenza A viruses detected in pigs are virulent and antigenically distinct from swine viruses endemic to the United States
D Rajão, P Gauger, T Anderson, N Lewis, E Abente, M Killian, D Perez, Troy Sutton, J Zhang, A Vincent, 2015, Journal of Virology on p. 11213-11222
Development of animal models against emerging coronaviruses: From SARS to MERS coronavirus
Troy C. Sutton, Kanta Subbarao, 2015, Virology on p. 247-258
Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibody
Katherine V. Houser, Andrew J. Broadbent, Lisa Gretebeck, Leatrice Vogel, Elaine W. Lamirande, Troy Sutton, Kevin W. Bock, Mahnaz Minai, Marlene Orandle, Ian N. Moore, Kanta Subbarao, 2017, PLoS Pathogens
Airborne transmission of highly pathogenic H7N1 influenza virus in ferrets
Troy C. Sutton, Courtney Finch, Hongxia Shao, Matthew Angel, Hongjun Chen, Ilaria Capua, Giovanni Cattoli, Isabella Monne, Daniel R. Pereza, 2014, Journal of Virology on p. 6623-6635
Influenza viruses with rearranged genomes as live-attenuated vaccines
Lindomar Pena, Troy Sutton, Ashok Chockalingam, Sachin Kumar, Matthew Angel, Hongxia Shao, Hongjun Chen, Weizhong Li, Daniel R. Perez, 2013, Journal of Virology on p. 5118-5127
Interactions between the influenza A virus RNA polymerase components and retinoic acid-inducible gene I
Weizhong Li, Hongjun Chen, Troy Sutton, Adebimpe Obadan, Daniel R. Perez, 2014, Journal of Virology on p. 10432-10447
Receptor Characterization and Susceptibility of Cotton Rats to Avian and 2009 Pandemic Influenza Virus Strains
Jorge C.G. Blanco, Lioubov M. Pletneva, Hongquan Wan, Yonas Araya, Matthew Angel, Raymonde O. Oue, Troy C. Sutton, Daniel R. Perez, 2013, Journal of Virology on p. 2036-2045
Alternative reassortment events leading to transmissible h9n1 influenza viruses in the ferret model
Brian J. Kimble, Matthew Angel, Hongquan Wan, Troy C. Sutton, Courtney Finch, Daniel R. Perez, 2014, Journal of Virology on p. 66-71
News Articles Featuring Troy Sutton
Jul 23, 2022
I study coronavirus in a highly secured biosafety lab – here's why I feel safer here than in the world outside
As I dilute the coronavirus to infect cultured cells, I hear the reassuring sound of purified air being blown by my respirator into my breathing space. There are three layers of nitrile and protective materials between me and the virus, and every part of my body is wrapped in protective equipment.
Full Article
Apr 29, 2022
Contagious Bird Flu Presents Low Risk to People After Colorado Case
Avian influenza has killed millions of birds in U.S. and infected one known person
Full Article
Oct 21, 2021
Preparing for potential pandemics is focus of new federal grant to Penn State
Researchers at Penn State have received a grant from the National Institute of Allergy and Infectious Diseases to study H7N9 with a goal of developing new and fundamental knowledge of virus mutations that could indicate the potential for transmissibility in humans.
Full Article
Jun 22, 2020
This supersafe labs protects researchers as they race to develop a coronavirus vaccine
It's quiet in the laboratory, almost peaceful. But I'm holding live SARS-CoV-2 in my hands and this virus is not to be taken lightly.
Full Article