Todd Schell

Professor Microbiology & Immunology

Todd Schell

Huck Affiliations

    Immunology & Infectious Disease

Publication Tags

T Lymphocytes Neoplasms Therapeutics Liver Neoplasms Growth Immunotherapy Acute Myeloid Leukemia Melanoma Liver Survival Tumor Microenvironment N Caproylsphingosine Nanotechnology Leukemia Immunity Neoplasm Antigens Recurrence Receptors, Adrenergic, Beta Adrenergic Receptors Hepatocellular Carcinoma Inflammation Stem Cell Transplantation Tyrosine Erythrocytes Carcinogenesis

Most Recent Papers

Multi-dimensional analysis identifies an immune signature predicting response to decitabine treatment in elderly patients with AML.

Chen Zhao, B Jia, Ming Wang, Todd Schell, David Claxton, W Ehmann, Witold Rybka, Shin Mineishi, Seema Naik, Natthapol Songdej, Jeffrey Sivik, Raymond Hohl, Huiqing Zeng, Hong Zheng, 2020, British journal of haematology on p. 674-684

Eomes<sup>+</sup>T-bet<sup>low</sup> CD8<sup>+</sup> T cells are functionally impaired and are associated with poor clinical outcome in patients with acute myeloid leukemia

Bei Jia, Chenchen Zhao, Kevin L. Rakszawski, David Claxton, W. Christopher Ehmann, Witold Rybka, Shin Mineishi, Ming Wang, Hiroko Shike, Michael Bayerl, Jeffrey M. Sivik, Todd Schell, Joseph Drabick, Raymond Hohl, Hong Zheng, 2019, Cancer Research on p. 1635-1645

Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity

Kathleen M. Kokolus, Jeremy S. Haley, Emily J. Koubek, Raghavendra Gowda, Saketh S. Dinavahi, Arati Sharma, David F. Claxton, Klaus F. Helm, Joseph J. Drabick, Gavin P. Robertson, Jeffrey D. Neighbors, Raymond J. Hohl, Todd D. Schell, 2019, OncoImmunology

Increased circulating microparticles in streptozotocin-induced diabetes propagate inflammation contributing to microvascular dysfunction

Qilong Feng, Christian J. Stork, Sulei Xu, Dong Yuan, Xinghai Xia, Kyle B. LaPenna, Ge Guo, Haoyu Sun, Li Chong Xu, Christopher A. Siedlecki, Kathleen M. Brundage, Nate Sheaffer, Todd D. Schell, Pingnian He, 2019, Journal of Physiology on p. 781-798

Aldehyde dehydrogenase in regulatory T-cell development, immunity and cancer.

C Bazewicz, S Dinavahi, Todd Schell, Gavin Robertson, 2019, Immunology on p. 47-55

Multi-dimensional analysis identifies an immune signature predicting response to decitabine treatment in elderly patients with AML

Chenchen Zhao, Bei Jia, Ming Wang, Todd D. Schell, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Shin Mineishi, Seema Naik, Natthapol Songdej, Jeff M. Sivik, Raymond J. Hohl, Hui Zeng, Hong Zheng, 2019, British Journal of Haematology

Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity.

K Kokolus, J Haley, E Koubek, R Gowda, S Dinavahi, Arati Sharma, David Claxton, Klaus Helm, Joseph Drabick, Gavin Robertson, Jeffrey Neighbors, Raymond Hohl, Todd Schell, 2018, Oncoimmunology on p. e1539614

Combined sublethal irradiation and agonist anti-CD40 enhance donor T cell accumulation and control of autochthonous murine pancreatic tumors

Lindsay K. Ward-Kavanagh, Kathleen M. Kokolus, Timothy K. Cooper, Aron Lukacher, Todd Schell, 2018, Cancer Immunology, Immunotherapy on p. 639-652

Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice

Kathleen M. Kokolus, Ying Zhang, Jeffrey M. Sivik, Carla Schmeck, Junjia Zhu, Elizabeth A. Repasky, Joseph J. Drabick, Todd D. Schell, 2018, OncoImmunology

Nanoliposome C6-Ceramide Increases the Anti-tumor Immune Response and Slows Growth of Liver Tumors in Mice

Guangfu Li, Dai Liu, Eric T. Kimchi, Jussuf T. Kaifi, Xiaoqiang Qi, Yariswamy Manjunath, Xinjian Liu, Tye Deering, Diego M. Avella, Todd Fox, Don C. Rockey, Todd D. Schell, Mark Kester, Kevin F. Staveley-O'Carroll, 2018, Gastroenterology on p. 1024-1036.e9

Most-Cited Papers

Tumor-specific T cell dysfunction Is a dynamic antigen-driven differentiation program initiated early during tumorigenesis

Andrea Schietinger, Mary Philip, Varintra E. Krisnawan, Edison Y. Chiu, Jeffrey J. Delrow, Ryan S. Basom, Peter Lauer, Dirk G. Brockstedt, Sue E. Knoblaugh, Günter J. Hämmerling, Todd Schell, Natalio Garbi, Philip D. Greenberg, 2016, Immunity on p. 389-401

T-cell immunoglobulin and ITIM domain (TIGIT) associates with CD8<sup>+</sup> T-cell exhaustion and poor clinical outcome in AML patients

Yaxian Kong, Liuluan Zhu, Todd D. Schell, Jianhong Zhang, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Melissa R. George, Hui Zeng, Hong Zheng, 2016, Clinical Cancer Research on p. 3057-3066

PD-1 <sup>hi</sup> TIM-3 <sup>+</sup> T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation

Y. Kong, J. Zhang, D. F. Claxton, W. C. Ehmann, W. B. Rybka, L. Zhu, H. Zeng, T. D. Schell, H. Zheng, 2015, Blood Cancer Journal

Randomized controlled trial of oral glutathione supplementation on body stores of glutathione

John P. Richie, Sailendra Nichenametla, Wanda Neidig, Ana Calcagnotto, Jeremy S. Haley, Todd D. Schell, Joshua E. Muscat, 2015, European Journal of Nutrition on p. 251-263

Regression of established hepatocellular carcinoma is induced by chemoimmunotherapy in an orthotopic murine model

Diego M. Avella, Guangfu Li, Todd D. Schell, Dai Liu, Samuel Shao Min Zhang, Xi Lou, Arthur Berg, Eric T. Kimchi, Hephzibah Rani S. Tagaram, Qing Yang, Serene Shereef, Luis S. Garcia, Mark Kester, Harriet C. Isom, C. Bart Rountree, Kevin F. Staveley-O'Carroll, 2012, Hepatology on p. 141-152

Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice

Kathleen M. Kokolus, Ying Zhang, Jeffrey M. Sivik, Carla Schmeck, Junjia Zhu, Elizabeth A. Repasky, Joseph J. Drabick, Todd D. Schell, 2018, OncoImmunology

Successful chemoimmunotherapy against hepatocellular cancer in a novel murine model

Guangfu Li, Dai Liu, Timothy K. Cooper, Eric T. Kimchi, Xiaoqiang Qi, Diego M. Avella, Ningfei Li, Qing X. Yang, Mark Kester, C. Bart Rountree, Jussuf T. Kaifi, David J. Cole, Don C. Rockey, Todd D. Schell, Kevin F. Staveley-O'Carroll, 2017, Journal of Hepatology on p. 75-85

Nanoliposome C6-Ceramide Increases the Anti-tumor Immune Response and Slows Growth of Liver Tumors in Mice

Guangfu Li, Dai Liu, Eric T. Kimchi, Jussuf T. Kaifi, Xiaoqiang Qi, Yariswamy Manjunath, Xinjian Liu, Tye Deering, Diego M. Avella, Todd Fox, Don C. Rockey, Todd D. Schell, Mark Kester, Kevin F. Staveley-O'Carroll, 2018, Gastroenterology on p. 1024-1036.e9

PD-1 blockade promotes epitope spreading in anticancer CD8+ T cell responses by preventing fratricidal death of subdominant clones to relieve immunodomination

Arash Memarnejadian, Courtney E. Meilleur, Christopher R. Shaler, Khashayarsha Khazaie, Jack R. Bennink, Todd D. Schell, S. M.Mansour Haeryfar, 2017, Journal of Immunology on p. 3348-3359

CD8 T cells recruited early in mouse polyomavirus infection undergo exhaustion

Jarad J. Wilson, Christopher D. Pack, Eugene Lin, Elizabeth L. Frost, Joshua A. Albrecht, Annette Hadley, Amelia R. Hofstetter, Satvir S. Tevethia, Todd D. Schell, Aron E. Lukacher, 2012, Journal of Immunology on p. 4340-4348