Todd Schell
Professor Microbiology & Immunology
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Hershey Med Ctr
Hershey, - tds6@psu.edu
Huck Affiliations
Publication Tags
Neoplasms T Lymphocytes Therapeutics Melanoma Acute Myeloid Leukemia Immunotherapy Leukemia Immunity Survival Aldehyde Dehydrogenase Growth Tumor Microenvironment Carcinogenesis Cells Transplants Pharmaceutical Preparations Differentiation Antigens Recurrence Liver Neoplasms Rna Calreticulin Immunogenic Cell Death Proteins Allogeneic Cells Stem Cell TransplantationMost Recent Publications
Drug-Tolerant Persister Cells in Cancer Therapy Resistance
Pavan Kumar Dhanyamraju, Todd D. Schell, Shantu Amin, Gavin P. Robertson, 2022, Cancer Research on p. 2503-2514
Small extracellular vesicles induce resistance to anti-GD2 immunotherapy unveiling tipifarnib as an adjunct to neuroblastoma immunotherapy
Xiaoming Liu, Carson A. Wills, Longgui Chen, Jiawen Zhang, Yuanjun Zhao, Mi Zhou, Jeffrey M. Sundstrom, Todd Schell, Vladimir S. Spiegelman, Megan Jones, Hong-Gang Wang, 2022, Journal for ImmunoTherapy of Cancer
Schweinfurthin induces ICD without ER stress and caspase activation
Ruoheng Zhang, J. D. Neighbors, T. D. Schell, R. J. Hohl, 2022, OncoImmunology
Angelica gigas: Signature Compounds, In Vivo Anticancer, Analgesic, Neuroprotective and Other Activities, and the Clinical Translation Challenges
Junxuan Lü, Cheng Jiang, Todd D. Schell, Monika Joshi, Jay D. Raman, Chengguo Xing, 2022, Comparative Medicine East and West on p. 1475-1527
A novel clinically relevant graft-versus-leukemia model in humanized mice
Bei Jia, Chenchen Zhao, Michael Bayerl, Hiroko Shike, David F. Claxton, W. Christopher Ehmann, Shin Mineishi, Todd D. Schell, Pan Zheng, Yi Zhang, Leonard D. Shultz, K. Sandeep Prabhu, Robert F. Paulson, Hong Zheng, 2021, Journal of Leukocyte Biology
Multi-dimensional analysis identifies an immune signature predicting response to decitabine treatment in elderly patients with AML
Chenchen Zhao, Bei Jia, Ming Wang, Todd D. Schell, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Shin Mineishi, Seema Naik, Natthapol Songdej, Jeff M. Sivik, Raymond J. Hohl, Hui Zeng, Hong Zheng, 2020, British Journal of Haematology on p. 674-684
Eomes<sup>+</sup>T-bet<sup>low</sup> CD8<sup>+</sup> T cells are functionally impaired and are associated with poor clinical outcome in patients with acute myeloid leukemia
Bei Jia, Chenchen Zhao, Kevin L. Rakszawski, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Shin Mineishi, Ming Wang, Hiroko Shike, Michael G. Bayerl, Jeffrey M. Sivik, Todd D. Schell, Joseph J. Drabick, Raymond J. Hohl, Hong Zheng, 2019, Cancer Research on p. 1635-1645
Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity
Kathleen M. Kokolus, Jeremy S. Haley, Emily J. Koubek, Raghavendra Gowda, Saketh S. Dinavahi, Arati Sharma, David F. Claxton, Klaus F. Helm, Joseph J. Drabick, Gavin P. Robertson, Jeffrey D. Neighbors, Raymond J. Hohl, Todd D. Schell, 2019, OncoImmunology
Aldehyde dehydrogenase in regulatory T-cell development, immunity and cancer
Christopher G. Bazewicz, Saketh S. Dinavahi, Todd D. Schell, Gavin P. Robertson, 2019, Immunology on p. 47-55
Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity.
K Kokolus, J Haley, E Koubek, R Gowda, S Dinavahi, Arati Sharma, David Claxton, Klaus Helm, Joseph Drabick, Gavin Robertson, Jeffrey Neighbors, Raymond Hohl, Todd Schell, 2018, Oncoimmunology on p. e1539614
Most-Cited Papers
Tumor-specific T cell dysfunction Is a dynamic antigen-driven differentiation program initiated early during tumorigenesis
Andrea Schietinger, Mary Philip, Varintra E. Krisnawan, Edison Y. Chiu, Jeffrey J. Delrow, Ryan S. Basom, Peter Lauer, Dirk G. Brockstedt, Sue E. Knoblaugh, Günter J. Hämmerling, Todd D. Schell, Natalio Garbi, Philip D. Greenberg, 2016, Immunity on p. 389-401
T-cell immunoglobulin and ITIM domain (TIGIT) associates with CD8<sup>+</sup> T-cell exhaustion and poor clinical outcome in AML patients
Yaxian Kong, Liuluan Zhu, Todd D. Schell, Jianhong Zhang, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Melissa R. George, Hui Zeng, Hong Zheng, 2016, Clinical Cancer Research on p. 3057-3066
PD-1 <sup>hi</sup> TIM-3 <sup>+</sup> T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation
Y. Kong, J. Zhang, D. F. Claxton, W. C. Ehmann, W. B. Rybka, L. Zhu, H. Zeng, T. D. Schell, H. Zheng, 2015, Blood Cancer Journal
Improved survival and complete response rates in patients with advanced melanoma treated with concurrent ipilimumab and radiotherapy versus ipilimumab alone
Kristian M. Koller, Heath B. Mackley, Jason Liu, Henry Wagner, Giampaolo Talamo, Todd D. Schell, Colette Pameijer, Rogerio I. Neves, Bryan Anderson, Kathleen M. Kokolus, Carol A. Mallon, Joseph J. Drabick, 2017, Cancer Biology and Therapy on p. 36-42
Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice
Kathleen M. Kokolus, Ying Zhang, Jeffrey M. Sivik, Carla Schmeck, Junjia Zhu, Elizabeth A. Repasky, Joseph J. Drabick, Todd D. Schell, 2018, OncoImmunology
Nanoliposome C6-ceramide increases the anti-tumor immune response and slows growth of liver tumors in mice
Guangfu Li, Dai Liu, Eric T. Kimchi, Jussuf T. Kaifi, Xiaoqiang Qi, Yariswamy Manjunath, Xinjian Liu, Tye Deering, Diego M. Avella, Todd Fox, Don C. Rockey, Todd D. Schell, Mark Kester, Kevin F. Staveley-O'Carroll, 2018, Gastroenterology on p. 1024-1036.e9
Circulating tumor cells in melanoma patients
Gary A. Clawson, Eric Kimchi, Susan D. Patrick, Ping Xin, Ramdane Harouaka, Siyang Zheng, Arthur Berg, Todd Schell, Kevin F. Staveley-O'Carroll, Rogerio I. Neves, Paul J. Mosca, Diane Thiboutot, 2012, PLoS One on p. e41052
Randomized controlled trial of oral glutathione supplementation on body stores of glutathione
John P. Richie, Sailendra Nichenametla, Wanda Neidig, Ana Calcagnotto, Jeremy S. Haley, Todd D. Schell, Joshua E. Muscat, 2015, Zeitschrift fur Ernahrungswissenschaft on p. 251-263
PD-1 blockade promotes epitope spreading in anticancer CD8+ T cell responses by preventing fratricidal death of subdominant clones to relieve immunodomination
Arash Memarnejadian, Courtney E. Meilleur, Christopher R. Shaler, Khashayarsha Khazaie, Jack R. Bennink, Todd D. Schell, S. M.Mansour Haeryfar, 2017, Journal of Immunology on p. 3348-3359
Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia
Liuluan Zhu, Yaxian Kong, Jianhong Zhang, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Neil D. Palmisiano, Ming Wang, Bei Jia, Michael Bayerl, Todd D. Schell, Raymond J. Hohl, Hui Zeng, Hong Zheng, 2017, Journal of Hematology and Oncology on p. 124