Todd Schell

Professor Microbiology & Immunology

Todd Schell

Huck Affiliations

Publication Tags

Neoplasms T Lymphocytes Therapeutics Melanoma Immunotherapy Acute Myeloid Leukemia Survival Liver Neoplasms Growth Glutathione Neoplasm Antigens Biomarkers Oxidative Stress Leukemia Immunity Erythrocytes Liver Recurrence Receptors, Adrenergic, Beta Adrenergic Receptors Clone Cells Cells Differentiation Antigens Tumor Microenvironment Rna

Most Recent Papers

Eomes<sup>+</sup>T-bet<sup>low</sup> CD8<sup>+</sup> T cells are functionally impaired and are associated with poor clinical outcome in patients with acute myeloid leukemia

Bei Jia, Chenchen Zhao, Kevin L. Rakszawski, David Claxton, W. Christopher Ehmann, Witold Rybka, Shin Mineishi, Ming Wang, Hiroko Shike, Michael Bayerl, Jeffrey M. Sivik, Todd Schell, Joseph Drabick, Raymond Hohl, Hong Zheng, 2019, Cancer Research on p. 1635-1645

Increased circulating microparticles in streptozotocin-induced diabetes propagate inflammation contributing to microvascular dysfunction

Qilong Feng, Christian J. Stork, Sulei Xu, Dong Yuan, Xinghai Xia, Kyle B. LaPenna, Ge Guo, Haoyu Sun, Li Chong Xu, Christopher A. Siedlecki, Kathleen M. Brundage, Nate Sheaffer, Todd D. Schell, Pingnian He, 2019, Journal of Physiology on p. 781-798

Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity

Kathleen M. Kokolus, Jeremy S. Haley, Emily J. Koubek, Raghavendra Gowda, Saketh S. Dinavahi, Arati Sharma, David F. Claxton, Klaus F. Helm, Joseph J. Drabick, Gavin P. Robertson, Jeffrey D. Neighbors, Raymond J. Hohl, Todd D. Schell, 2019, OncoImmunology

Multi-dimensional analysis identifies an immune signature predicting response to decitabine treatment in elderly patients with AML

Chenchen Zhao, Bei Jia, Ming Wang, Todd D. Schell, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Shin Mineishi, Seema Naik, Natthapol Songdej, Jeff M. Sivik, Raymond J. Hohl, Hui Zeng, Hong Zheng, 2019, British Journal of Haematology

Combined sublethal irradiation and agonist anti-CD40 enhance donor T cell accumulation and control of autochthonous murine pancreatic tumors

Lindsay K. Ward-Kavanagh, Kathleen M. Kokolus, Timothy K. Cooper, Aron Lukacher, Todd Schell, 2018, Cancer Immunology, Immunotherapy on p. 639-652

Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice

Kathleen M. Kokolus, Ying Zhang, Jeffrey M. Sivik, Carla Schmeck, Junjia Zhu, Elizabeth A. Repasky, Joseph J. Drabick, Todd D. Schell, 2018, OncoImmunology

Nanoliposome C6-Ceramide Increases the Anti-tumor Immune Response and Slows Growth of Liver Tumors in Mice

Guangfu Li, Dai Liu, Eric T. Kimchi, Jussuf T. Kaifi, Xiaoqiang Qi, Yariswamy Manjunath, Xinjian Liu, Tye Deering, Diego M. Avella, Todd Fox, Don C. Rockey, Todd D. Schell, Mark Kester, Kevin F. Staveley-O'Carroll, 2018, Gastroenterology on p. 1024-1036.e9

PD-1/PD-L1 co-inhibition shapes anticancer T cell immunodominance

S. M.Mansour Haeryfar, Todd D. Schell, 2018, Cancer Immunology, Immunotherapy

Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function

Raghu Sinha, Indu Sinha, A. Calcagnotto, N. Trushin, J. S. Haley, Todd Schell, John Richie, 2018, European Journal of Clinical Nutrition on p. 105-111

Mouse papillomavirus infection persists in mucosal tissues of an immunocompetent mouse strain and progresses to cancer

Nancy M. Cladel, Lynn R. Budgeon, Karla K. Balogh, Timothy K. Cooper, Sarah A. Brendle, Neil D. Christensen, Todd D. Schell, Jiafen Hu, 2017, Scientific reports

Most-Cited Papers

Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis

Andrea Schietinger, Mary Philip, Varintra E. Krisnawan, Edison Y. Chiu, Jeffrey J. Delrow, Ryan S. Basom, Peter Lauer, Dirk G. Brockstedt, Sue E. Knoblaugh, Günter J. Hämmerling, Todd Schell, Natalio Garbi, Philip D. Greenberg, 2016, Immunity on p. 389-401

T-cell immunoglobulin and ITIM domain (TIGIT) associates with CD8<sup>+</sup> T-cell exhaustion and poor clinical outcome in AML patients

Yaxian Kong, Liuluan Zhu, Todd D. Schell, Jianhong Zhang, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Melissa R. George, Hui Zeng, Hong Zheng, 2016, Clinical Cancer Research on p. 3057-3066

PD-1 <sup>hi</sup> TIM-3 <sup>+</sup> T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation

Y. Kong, J. Zhang, D. F. Claxton, W. C. Ehmann, W. B. Rybka, L. Zhu, H. Zeng, T. D. Schell, H. Zheng, 2015, Blood Cancer Journal

Circulating tumor cells in melanoma patients

Gary A. Clawson, Eric Kimchi, Susan D. Patrick, Ping Xin, Ramdane Harouaka, Siyang Zheng, Arthur Berg, Todd Schell, Kevin F. Staveley-O'Carroll, Rogerio I. Neves, Paul J. Mosca, Diane Thiboutot, 2012, PloS one

Randomized controlled trial of oral glutathione supplementation on body stores of glutathione

John P. Richie, Sailendra Nichenametla, Wanda Neidig, Ana Calcagnotto, Jeremy S. Haley, Todd D. Schell, Joshua E. Muscat, 2015, European Journal of Nutrition on p. 251-263

Regression of established hepatocellular carcinoma is induced by chemoimmunotherapy in an orthotopic murine model

Diego M. Avella, Guangfu Li, Todd D. Schell, Dai Liu, Samuel Shao Min Zhang, Xi Lou, Arthur Berg, Eric T. Kimchi, Hephzibah Rani S. Tagaram, Qing Yang, Serene Shereef, Luis S. Garcia, Mark Kester, Harriet C. Isom, C. Bart Rountree, Kevin F. Staveley-O'Carroll, 2012, Hepatology on p. 141-152

Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice

Kathleen M. Kokolus, Ying Zhang, Jeffrey M. Sivik, Carla Schmeck, Junjia Zhu, Elizabeth A. Repasky, Joseph J. Drabick, Todd D. Schell, 2018, OncoImmunology

Successful chemoimmunotherapy against hepatocellular cancer in a novel murine model

Guangfu Li, Dai Liu, Timothy K. Cooper, Eric T. Kimchi, Xiaoqiang Qi, Diego M. Avella, Ningfei Li, Qing X. Yang, Mark Kester, C. Bart Rountree, Jussuf T. Kaifi, David J. Cole, Don C. Rockey, Todd D. Schell, Kevin F. Staveley-O'Carroll, 2017, Journal of Hepatology on p. 75-85

Durable complete responses off all treatment in patients with metastatic malignant melanoma after sequential immunotherapy followed by a finite course of BRAF inhibitor therapy

Edward J. Wyluda, Jihua Cheng, Todd D. Schell, Jeremy S. Haley, Carol Mallon, Rogerio I. Neves, Gavin Robertson, Jeffrey Sivik, Heath Mackley, Giampaolo Talamo, Joseph J. Drabick, 2015, Cancer Biology and Therapy on p. 662-670

PD-1 blockade promotes epitope spreading in anticancer CD8+ T cell responses by preventing fratricidal death of subdominant clones to relieve immunodomination

Arash Memarnejadian, Courtney E. Meilleur, Christopher R. Shaler, Khashayarsha Khazaie, Jack R. Bennink, Todd D. Schell, S. M.Mansour Haeryfar, 2017, Journal of Immunology on p. 3348-3359