Todd Schell

Professor Microbiology & Immunology

Todd Schell

Huck Affiliations

    Immunology & Infectious Disease

Publication Tags

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Neoplasms T Lymphocytes Therapeutics Acute Myeloid Leukemia Immunotherapy Survival Leukemia Melanoma Radiotherapy Glutathione Oxidative Stress Tumor Microenvironment Biomarkers Growth Erythrocytes Transplants Pharmaceutical Preparations Recurrence Liver Neoplasms Allogeneic Cells Stem Cell Transplantation Immunoglobulins Tyrosine Decitabine Urinary Bladder Neoplasms

Most Recent Publications

Novel fourth generation-like CAR<sup>miR</sup> cells release therapeutic miRNA via exosomes and enhance glioblastoma cell killing activity

Amar Yeware, Angelica Helton, Yicheng Dong, Cheng Dong, Justin Pritchard, Shin Mineishi, Kentaro Minagawa, Todd Schell, Daniel Hayes, 2023, Biochemical Engineering Journal

Sexually dimorphic effect of H-ferritin genetic manipulation on survival and tumor microenvironment in a mouse model of glioblastoma

Bhavyata Pandya Shesh, Vonn Walter, Kondaiah Palsa, Becky Slagle-Webb, Elizabeth Neely, Todd Schell, James R. Connor, 2023, Journal of Neuro-Oncology on p. 569-586

Concurrent durvalumab and radiation therapy (DUART) followed by adjuvant durvalumab in patients with localized urothelial cancer of bladder: Results from phase II study, BTCRC-GU15-023

Monika Joshi, Leonard Tuanquin, J Zhu, Vonn Walter, Todd Schell, Matthew Kaag, Deepak Kilari, Jiangang Liao, S Holder, Hamid Emamekhoo, A Sankin, S Merrill, Hong Zheng, Joshua Warrick, R Hauke, Benjamin Gartrel, B Gartel, M Stein, Joseph Drabick, David J. Degraff, Y Zakharia, 2023, Journal for ImmunoTherapy of Cancer

IGF2BP family of RNA-binding proteins regulate innate and adaptive immune responses in cancer cells and tumor microenvironment

Irina A. Elcheva, Chethana P. Gowda, Daniel Bogush, Svetlana Gornostaeva, Anna Fakhardo, Neil Sheth, Kathleen M. Kokolus, Arati Sharma, Sinisa Dovat, Yasin Uzun, Todd D. Schell, Vladimir S. Spiegelman, 2023, Frontiers in Immunology

Drug-Tolerant Persister Cells in Cancer Therapy Resistance

Pavan Kumar Dhanyamraju, Todd D. Schell, Shantu Amin, Gavin P. Robertson, 2022, Cancer Research on p. 2503-2514

Small extracellular vesicles induce resistance to anti-GD2 immunotherapy unveiling tipifarnib as an adjunct to neuroblastoma immunotherapy

Xiaoming Liu, Carson A. Wills, Longgui Chen, Jiawen Zhang, Yuanjun Zhao, Mi Zhou, Jeffrey Sundstrom, Todd Schell, Vladimir S. Spiegelman, Megan M. Young, Hong Gang Wang, 2022, Journal for ImmunoTherapy of Cancer

Schweinfurthin induces ICD without ER stress and caspase activation

Ruoheng Zhang, J. D. Neighbors, T. D. Schell, R. J. Hohl, 2022, OncoImmunology

Angelica gigas: Signature Compounds, In Vivo Anticancer, Analgesic, Neuroprotective and Other Activities, and the Clinical Translation Challenges

Junxuan Lü, Cheng Jiang, Todd D. Schell, Monika Joshi, Jay D. Raman, Chengguo Xing, 2022, Comparative Medicine East and West on p. 1475-1527

A novel clinically relevant graft-versus-leukemia model in humanized mice

B Jia, C Zhao, Michael Bayerl, Hiroko Shike, David F. Claxton, W Ehmann, Shin Mineishi, Todd D. Schell, P Zheng, Y Zhang, L Shultz, K. Sandeep Prabhu, Robert Paulson, Hong Zheng, 2021, Journal of Leukocyte Biology on p. 427-437

Multi-dimensional analysis identifies an immune signature predicting response to decitabine treatment in elderly patients with AML

Chenchen Zhao, Bei Jia, Ming Wang, Todd D. Schell, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Shin Mineishi, Seema Naik, Natthapol Songdej, Jeff M. Sivik, Raymond J. Hohl, Hui Zeng, Hong Zheng, 2020, British Journal of Haematology on p. 674-684

Most-Cited Papers

Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis

Andrea Schietinger, Mary Philip, Varintra E. Krisnawan, Edison Y. Chiu, Jeffrey J. Delrow, Ryan S. Basom, Peter Lauer, Dirk G. Brockstedt, Sue E. Knoblaugh, Günter J. Hämmerling, Todd D. Schell, Natalio Garbi, Philip D. Greenberg, 2016, Immunity on p. 389-401

T-cell immunoglobulin and ITIM domain (TIGIT) associates with CD8<sup>+</sup> T-cell exhaustion and poor clinical outcome in AML patients

Yaxian Kong, Liuluan Zhu, Todd D. Schell, Jianhong Zhang, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Melissa R. George, Hui Zeng, Hong Zheng, 2016, Clinical Cancer Research on p. 3057-3066

PD-1<sup>hi</sup>TIM-3<sup>+</sup> T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation

Y Kong, J Zhang, D. F. Claxton, W. C. Ehmann, W. B. Rybka, L Zhu, H Zeng, T. D. Schell, H. Zheng, 2015, Blood Cancer Journal on p. e330--e330

Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice

Kathleen M. Kokolus, Ying Zhang, Jeffrey M. Sivik, Carla Schmeck, Junjia Zhu, Elizabeth A. Repasky, Joseph J. Drabick, Todd D. Schell, 2018, OncoImmunology

Improved survival and complete response rates in patients with advanced melanoma treated with concurrent ipilimumab and radiotherapy versus ipilimumab alone

Kristian Koller, H Mackley, Jason Liu, H Wagner, Giampaolo Talamo, Todd D. Schell, Colette Pameijer, R Neves, Bryan Anderson, Kathleen Kokolus, Carol Mallon, Joseph J. Drabick, 2017, Cancer Biology and Therapy on p. 36-42

Nanoliposome C6-Ceramide Increases the Anti-tumor Immune Response and Slows Growth of Liver Tumors in Mice

Guangfu Li, Dai Liu, Eric T. Kimchi, Jussuf T. Kaifi, Xiaoqiang Qi, Yariswamy Manjunath, Xinjian Liu, Tye Deering, Diego M. Avella, Todd Fox, Don C. Rockey, Todd D. Schell, Mark Kester, Kevin F. Staveley-O'Carroll, 2018, Gastroenterology on p. 1024-1036.e9

Randomized controlled trial of oral glutathione supplementation on body stores of glutathione

John P. Richie, Sailendra Nichenametla, Wanda Neidig, Ana Calcagnotto, Jeremy S. Haley, Todd D. Schell, Joshua E. Muscat, 2015, Zeitschrift fur Ernahrungswissenschaft on p. 251-263

PD-1 blockade promotes epitope spreading in anticancer CD8+ T cell responses by preventing fratricidal death of subdominant clones to relieve immunodomination

Arash Memarnejadian, Courtney E. Meilleur, Christopher R. Shaler, Khashayarsha Khazaie, Jack R. Bennink, Todd D. Schell, S. M.Mansour Haeryfar, 2017, Journal of Immunology on p. 3348-3359

Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function

R. Sinha, I. Sinha, A Calcagnotto, N Trushin, J Haley, T. D. Schell, J. P. Richie, J Richie, Jr, 2018, European Journal of Clinical Nutrition on p. 105-111

Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia

Liuluan Zhu, Yaxian Kong, Jianhong Zhang, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Neil D. Palmisiano, Ming Wang, Bei Jia, Michael Bayerl, Todd D. Schell, Raymond J. Hohl, Hui Zeng, Hong Zheng, 2017, Journal of Hematology and Oncology on p. 124