Todd Schell
Professor Microbiology & Immunology

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Hershey Med Ctr
Hershey, - tds6@psu.edu
Huck Affiliations
Publication Tags
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Neoplasms T Lymphocytes Therapeutics Acute Myeloid Leukemia Immunotherapy Survival Leukemia Melanoma Radiotherapy Glutathione Oxidative Stress Tumor Microenvironment Biomarkers Growth Erythrocytes Transplants Pharmaceutical Preparations Recurrence Liver Neoplasms Allogeneic Cells Stem Cell Transplantation Immunoglobulins Tyrosine Decitabine Urinary Bladder NeoplasmsMost Recent Publications
Novel fourth generation-like CAR<sup>miR</sup> cells release therapeutic miRNA via exosomes and enhance glioblastoma cell killing activity
Amar Yeware, Angelica Helton, Yicheng Dong, Cheng Dong, Justin Pritchard, Shin Mineishi, Kentaro Minagawa, Todd Schell, Daniel Hayes, 2023, Biochemical Engineering Journal
Sexually dimorphic effect of H-ferritin genetic manipulation on survival and tumor microenvironment in a mouse model of glioblastoma
Bhavyata Pandya Shesh, Vonn Walter, Kondaiah Palsa, Becky Slagle-Webb, Elizabeth Neely, Todd Schell, James R. Connor, 2023, Journal of Neuro-Oncology on p. 569-586
Concurrent durvalumab and radiation therapy (DUART) followed by adjuvant durvalumab in patients with localized urothelial cancer of bladder: Results from phase II study, BTCRC-GU15-023
Monika Joshi, Leonard Tuanquin, J Zhu, Vonn Walter, Todd Schell, Matthew Kaag, Deepak Kilari, Jiangang Liao, S Holder, Hamid Emamekhoo, A Sankin, S Merrill, Hong Zheng, Joshua Warrick, R Hauke, Benjamin Gartrel, B Gartel, M Stein, Joseph Drabick, David J. Degraff, Y Zakharia, 2023, Journal for ImmunoTherapy of Cancer
IGF2BP family of RNA-binding proteins regulate innate and adaptive immune responses in cancer cells and tumor microenvironment
Irina A. Elcheva, Chethana P. Gowda, Daniel Bogush, Svetlana Gornostaeva, Anna Fakhardo, Neil Sheth, Kathleen M. Kokolus, Arati Sharma, Sinisa Dovat, Yasin Uzun, Todd D. Schell, Vladimir S. Spiegelman, 2023, Frontiers in Immunology
Drug-Tolerant Persister Cells in Cancer Therapy Resistance
Pavan Kumar Dhanyamraju, Todd D. Schell, Shantu Amin, Gavin P. Robertson, 2022, Cancer Research on p. 2503-2514
Small extracellular vesicles induce resistance to anti-GD2 immunotherapy unveiling tipifarnib as an adjunct to neuroblastoma immunotherapy
Xiaoming Liu, Carson A. Wills, Longgui Chen, Jiawen Zhang, Yuanjun Zhao, Mi Zhou, Jeffrey Sundstrom, Todd Schell, Vladimir S. Spiegelman, Megan M. Young, Hong Gang Wang, 2022, Journal for ImmunoTherapy of Cancer
Schweinfurthin induces ICD without ER stress and caspase activation
Ruoheng Zhang, J. D. Neighbors, T. D. Schell, R. J. Hohl, 2022, OncoImmunology
Angelica gigas: Signature Compounds, In Vivo Anticancer, Analgesic, Neuroprotective and Other Activities, and the Clinical Translation Challenges
Junxuan Lü, Cheng Jiang, Todd D. Schell, Monika Joshi, Jay D. Raman, Chengguo Xing, 2022, Comparative Medicine East and West on p. 1475-1527
A novel clinically relevant graft-versus-leukemia model in humanized mice
B Jia, C Zhao, Michael Bayerl, Hiroko Shike, David F. Claxton, W Ehmann, Shin Mineishi, Todd D. Schell, P Zheng, Y Zhang, L Shultz, K. Sandeep Prabhu, Robert Paulson, Hong Zheng, 2021, Journal of Leukocyte Biology on p. 427-437
Multi-dimensional analysis identifies an immune signature predicting response to decitabine treatment in elderly patients with AML
Chenchen Zhao, Bei Jia, Ming Wang, Todd D. Schell, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Shin Mineishi, Seema Naik, Natthapol Songdej, Jeff M. Sivik, Raymond J. Hohl, Hui Zeng, Hong Zheng, 2020, British Journal of Haematology on p. 674-684
Most-Cited Papers
Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis
Andrea Schietinger, Mary Philip, Varintra E. Krisnawan, Edison Y. Chiu, Jeffrey J. Delrow, Ryan S. Basom, Peter Lauer, Dirk G. Brockstedt, Sue E. Knoblaugh, Günter J. Hämmerling, Todd D. Schell, Natalio Garbi, Philip D. Greenberg, 2016, Immunity on p. 389-401
T-cell immunoglobulin and ITIM domain (TIGIT) associates with CD8<sup>+</sup> T-cell exhaustion and poor clinical outcome in AML patients
Yaxian Kong, Liuluan Zhu, Todd D. Schell, Jianhong Zhang, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Melissa R. George, Hui Zeng, Hong Zheng, 2016, Clinical Cancer Research on p. 3057-3066
PD-1<sup>hi</sup>TIM-3<sup>+</sup> T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation
Y Kong, J Zhang, D. F. Claxton, W. C. Ehmann, W. B. Rybka, L Zhu, H Zeng, T. D. Schell, H. Zheng, 2015, Blood Cancer Journal on p. e330--e330
Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice
Kathleen M. Kokolus, Ying Zhang, Jeffrey M. Sivik, Carla Schmeck, Junjia Zhu, Elizabeth A. Repasky, Joseph J. Drabick, Todd D. Schell, 2018, OncoImmunology
Improved survival and complete response rates in patients with advanced melanoma treated with concurrent ipilimumab and radiotherapy versus ipilimumab alone
Kristian Koller, H Mackley, Jason Liu, H Wagner, Giampaolo Talamo, Todd D. Schell, Colette Pameijer, R Neves, Bryan Anderson, Kathleen Kokolus, Carol Mallon, Joseph J. Drabick, 2017, Cancer Biology and Therapy on p. 36-42
Nanoliposome C6-Ceramide Increases the Anti-tumor Immune Response and Slows Growth of Liver Tumors in Mice
Guangfu Li, Dai Liu, Eric T. Kimchi, Jussuf T. Kaifi, Xiaoqiang Qi, Yariswamy Manjunath, Xinjian Liu, Tye Deering, Diego M. Avella, Todd Fox, Don C. Rockey, Todd D. Schell, Mark Kester, Kevin F. Staveley-O'Carroll, 2018, Gastroenterology on p. 1024-1036.e9
Randomized controlled trial of oral glutathione supplementation on body stores of glutathione
John P. Richie, Sailendra Nichenametla, Wanda Neidig, Ana Calcagnotto, Jeremy S. Haley, Todd D. Schell, Joshua E. Muscat, 2015, Zeitschrift fur Ernahrungswissenschaft on p. 251-263
PD-1 blockade promotes epitope spreading in anticancer CD8+ T cell responses by preventing fratricidal death of subdominant clones to relieve immunodomination
Arash Memarnejadian, Courtney E. Meilleur, Christopher R. Shaler, Khashayarsha Khazaie, Jack R. Bennink, Todd D. Schell, S. M.Mansour Haeryfar, 2017, Journal of Immunology on p. 3348-3359
Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function
R. Sinha, I. Sinha, A Calcagnotto, N Trushin, J Haley, T. D. Schell, J. P. Richie, J Richie, Jr, 2018, European Journal of Clinical Nutrition on p. 105-111
Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia
Liuluan Zhu, Yaxian Kong, Jianhong Zhang, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Neil D. Palmisiano, Ming Wang, Bei Jia, Michael Bayerl, Todd D. Schell, Raymond J. Hohl, Hui Zeng, Hong Zheng, 2017, Journal of Hematology and Oncology on p. 124