Todd Schell
Professor Microbiology & Immunology

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Hershey Med Ctr
Hershey, - tds6@psu.edu
Huck Affiliations
Most Recent Publications
Tumor Heterogeneity Shapes Survival Dynamics in Drug-Treated Cells, Revealing Size-Drifting Subpopulations
Venugopal Vangala, Yu Chi Chen, Saketh S. Dinavahi, Krishne Gowda, Nazir A. Lone, Meenhard Herlyn, Joseph Drabick, Klaus Helm, Jiyue Zhu, Rogerio I. Neves, Arun K. Sharma, Arthur Berg, Marco Archetti, Shantu Amin, Todd D. Schell, Gavin P. Robertson, 2024, ACS Pharmacology and Translational Science on p. 3573-3584
Optogenetically engineered Septin-7 enhances immune cell infiltration of tumor spheroids
Jiaxing Chen, Brianna Hnath, Congzhou M. Sha, Lynne Beidler, Todd D. Schell, Nikolay V. Dokholyan, 2024, Proceedings of the National Academy of Sciences of the United States of America
Identification of Novel Isatin Derivative Bearing a Nitrofuran Moiety as Potent Multi-Isoform Aldehyde Dehydrogenase Inhibitor
Krishne Gowda, Asif Raza, Venugopal Vangala, Nazir Ahmad Lone, Jyh Ming Lin, Jaikee Kumar Singh, Sandeep Kumar Srivastava, Todd D. Schell, Gavin P. Robertson, Shantu Amin, Arun K. Sharma, 2024, Molecules
Targeting Tyro3, Axl, and MerTK Receptor Tyrosine Kinases Significantly Sensitizes Triple-Negative Breast Cancer to CDK4/6 Inhibition
S Demirsoy, H Tran, J Liu, Y Li, Shengyu Yang, Dawit Aregawi, Michael J. Glantz, N Jacob, Vonn Walter, Todd Schell, Inan Olmez, 2024, Cancers on p. 2253
Pharmacological agents targeting drug-tolerant persister cells in cancer
Yu Chi Chen, Krishne Gowda, Shantu Amin, Todd D. Schell, Arun K. Sharma, Gavin P. Robertson, 2024, Pharmacological Research
Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model
Bei Jia, Chenchen Zhao, Kentaro Minagawa, Hiroko Shike, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Shin Mineishi, Ming Wang, Todd D. Schell, K. Sandeep Prabhu, Robert F. Paulson, Yi Zhang, Leonard D. Shultz, Hong Zheng, 2023, Journal of Immunology on p. 1426-1437
Novel fourth generation-like CAR<sup>miR</sup> cells release therapeutic miRNA via exosomes and enhance glioblastoma cell killing activity
Amar Yeware, Angelica Helton, Yicheng Dong, Cheng Dong, Justin Pritchard, Kentaro Minagawa, Shin Mineishi, Todd Schell, Daniel Hayes, 2023, Biochemical Engineering Journal on p. 109068
Complementarity between Microbiome and Immunity May Account for the Potentiating Effect of Quercetin on the Antitumor Action of Cyclophosphamide in a Triple-Negative Breast Cancer Model
Andrea Manni, Yuan Wan Sun, Todd D. Schell, Tymofiy Lutsiv, Henry Thompson, Kun Ming Chen, Cesar Aliaga, Junjia Zhu, Karam El-Bayoumy, 2023, Pharmaceuticals
Sexually dimorphic effect of H-ferritin genetic manipulation on survival and tumor microenvironment in a mouse model of glioblastoma
B Pandya Shesh, Vonn Walter, K Palsa, B Slagle-Webb, E Neely, Todd Schell, James R. Connor, 2023, Journal of Neuro-Oncology on p. 569-586
Concurrent durvalumab and radiation therapy (DUART) followed by adjuvant durvalumab in patients with localized urothelial cancer of bladder: Results from phase II study, BTCRC-GU15-023
Monika Joshi, Leonard Tuanquin, J Zhu, Vonn Walter, Todd Schell, Matthew Kaag, Deepak Kilari, Jiangang Liao, S Holder, Hamid Emamekhoo, A Sankin, S Merrill, Hong Zheng, Joshua Warrick, R Hauke, Benjamin Gartrel, B Gartel, M Stein, Joseph Drabick, David J. Degraff, Y Zakharia, 2023, Journal for ImmunoTherapy of Cancer
Most-Cited Papers
Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis
Andrea Schietinger, Mary Philip, Varintra E. Krisnawan, Edison Y. Chiu, Jeffrey J. Delrow, Ryan S. Basom, Peter Lauer, Dirk G. Brockstedt, Sue E. Knoblaugh, Günter J. Hämmerling, Todd D. Schell, Natalio Garbi, Philip D. Greenberg, 2016, Immunity on p. 389-401
T-cell immunoglobulin and ITIM domain (TIGIT) associates with CD8<sup>+</sup> T-cell exhaustion and poor clinical outcome in AML patients
Yaxian Kong, Liuluan Zhu, Todd D. Schell, Jianhong Zhang, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Melissa R. George, Hui Zeng, Hong Zheng, 2016, Clinical Cancer Research on p. 3057-3066
Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice
Kathleen M. Kokolus, Ying Zhang, Jeffrey M. Sivik, Carla Schmeck, Junjia Zhu, Elizabeth A. Repasky, Joseph J. Drabick, Todd D. Schell, 2018, OncoImmunology
PD-1<sup>hi</sup>TIM-3<sup>+</sup> T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation
Y Kong, J Zhang, D. F. Claxton, W. C. Ehmann, W. B. Rybka, L Zhu, H Zeng, T. D. Schell, H. Zheng, 2015, Blood Cancer Journal on p. e330--e330
Nanoliposome C6-Ceramide Increases the Anti-tumor Immune Response and Slows Growth of Liver Tumors in Mice
Guangfu Li, Dai Liu, Eric T. Kimchi, Jussuf T. Kaifi, Xiaoqiang Qi, Yariswamy Manjunath, Xinjian Liu, Tye Deering, Diego M. Avella, Todd Fox, Don C. Rockey, Todd D. Schell, Mark Kester, Kevin F. Staveley-O'Carroll, 2018, Gastroenterology on p. 1024-1036.e9
Improved survival and complete response rates in patients with advanced melanoma treated with concurrent ipilimumab and radiotherapy versus ipilimumab alone
Kristian Koller, H Mackley, Jason Liu, H Wagner, Giampaolo Talamo, Todd D. Schell, Colette Pameijer, R Neves, Bryan Anderson, Kathleen Kokolus, Carol Mallon, Joseph J. Drabick, 2017, Cancer Biology and Therapy on p. 36-42
Randomized controlled trial of oral glutathione supplementation on body stores of glutathione
John P. Richie, Sailendra Nichenametla, Wanda Neidig, Ana Calcagnotto, Jeremy S. Haley, Todd D. Schell, Joshua E. Muscat, 2015, Zeitschrift fur Ernahrungswissenschaft on p. 251-263
Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function
R. Sinha, I. Sinha, A Calcagnotto, N Trushin, J Haley, T. D. Schell, J. P. Richie, J Richie, Jr, 2018, European Journal of Clinical Nutrition on p. 105-111
PD-1 blockade promotes epitope spreading in anticancer CD8+ T cell responses by preventing fratricidal death of subdominant clones to relieve immunodomination
Arash Memarnejadian, Courtney E. Meilleur, Christopher R. Shaler, Khashayarsha Khazaie, Jack R. Bennink, Todd D. Schell, S. M.Mansour Haeryfar, 2017, Journal of Immunology on p. 3348-3359
Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia
Liuluan Zhu, Yaxian Kong, Jianhong Zhang, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Neil D. Palmisiano, Ming Wang, Bei Jia, Michael Bayerl, Todd D. Schell, Raymond J. Hohl, Hui Zeng, Hong Zheng, 2017, Journal of Hematology and Oncology on p. 124
News Articles Featuring Todd Schell
Oct 23, 2024
Re-engineered, blue light-activated immune cells penetrate and kill solid tumors
A team led by researchers from the Penn State College of Medicine has re-engineered immune cells so that they can penetrate and kill solid tumors grown in the lab.
Full Article