Todd Schell

Professor Microbiology & Immunology

Todd Schell

Huck Affiliations

    Immunology & Infectious Disease

Publication Tags

Neoplasms T Lymphocytes Therapeutics Melanoma Survival Immunotherapy Acute Myeloid Leukemia Growth Immunity Liver Liver Neoplasms Tumor Microenvironment Nanotechnology N Caproylsphingosine Glutathione Oxidative Stress Biomarkers Leukemia Erythrocytes Recurrence Receptors, Adrenergic, Beta Adrenergic Receptors Carcinogenesis Cells Macrophages

Most Recent Papers

Multi-dimensional analysis identifies an immune signature predicting response to decitabine treatment in elderly patients with AML

Chenchen Zhao, Bei Jia, Ming Wang, Todd D. Schell, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Shin Mineishi, Seema Naik, Natthapol Songdej, Jeff M. Sivik, Raymond J. Hohl, Hui Zeng, Hong Zheng, 2020, British Journal of Haematology on p. 674-684

Eomes<sup>+</sup>T-bet<sup>low</sup> CD8<sup>+</sup> T cells are functionally impaired and are associated with poor clinical outcome in patients with acute myeloid leukemia

Bei Jia, Chenchen Zhao, Kevin L. Rakszawski, David Claxton, W. Christopher Ehmann, Witold Rybka, Shin Mineishi, Ming Wang, Hiroko Shike, Michael Bayerl, Jeffrey M. Sivik, Todd Schell, Joseph Drabick, Raymond Hohl, Hong Zheng, 2019, Cancer Research on p. 1635-1645

Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity

Kathleen M. Kokolus, Jeremy S. Haley, Emily J. Koubek, Raghavendra Gowda, Saketh S. Dinavahi, Arati Sharma, David F. Claxton, Klaus F. Helm, Joseph J. Drabick, Gavin P. Robertson, Jeffrey D. Neighbors, Raymond J. Hohl, Todd D. Schell, 2019, OncoImmunology

Aldehyde dehydrogenase in regulatory T-cell development, immunity and cancer

Christopher G. Bazewicz, Saketh S. Dinavahi, Todd D. Schell, Gavin P. Robertson, 2019, Immunology on p. 47-55

Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity.

K Kokolus, J Haley, E Koubek, R Gowda, S Dinavahi, Arati Sharma, David Claxton, Klaus Helm, Joseph Drabick, Gavin Robertson, Jeffrey Neighbors, Raymond Hohl, Todd Schell, 2018, Oncoimmunology on p. e1539614

Combined sublethal irradiation and agonist anti-CD40 enhance donor T cell accumulation and control of autochthonous murine pancreatic tumors

Lindsay K. Ward-Kavanagh, Kathleen M. Kokolus, Timothy K. Cooper, Aron Lukacher, Todd Schell, 2018, Cancer Immunology and Immunotherapy on p. 639-652

Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice

Kathleen M. Kokolus, Ying Zhang, Jeffrey M. Sivik, Carla Schmeck, Junjia Zhu, Elizabeth A. Repasky, Joseph J. Drabick, Todd D. Schell, 2018, OncoImmunology

Nanoliposome C6-ceramide increases the anti-tumor immune response and slows growth of liver tumors in mice

Guangfu Li, Dai Liu, Eric T. Kimchi, Jussuf T. Kaifi, Xiaoqiang Qi, Yariswamy Manjunath, Xinjian Liu, Tye Deering, Diego M. Avella, Todd Fox, Don C. Rockey, Todd D. Schell, Mark Kester, Kevin F. Staveley-O'Carroll, 2018, Gastroenterology on p. 1024-1036.e9

Bone marrow CD8 T cells express high frequency of PD-1 and exhibit reduced anti-leukemia response in newly diagnosed AML patients

Bei Jia, Liru Wang, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Shin Mineishi, Syed Rizvi, Hiroko Shike, Michael Bayerl, Todd D. Schell, Raymond J. Hohl, Hong Zheng, 2018, Blood Cancer Journal

Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function

Raghu Sinha, Indu Sinha, A. Calcagnotto, N. Trushin, J. S. Haley, Todd Schell, John Richie, 2018, European Journal of Clinical Nutrition on p. 105-111

Most-Cited Papers

Tumor-specific T cell dysfunction Is a dynamic antigen-driven differentiation program initiated early during tumorigenesis

Andrea Schietinger, Mary Philip, Varintra E. Krisnawan, Edison Y. Chiu, Jeffrey J. Delrow, Ryan S. Basom, Peter Lauer, Dirk G. Brockstedt, Sue E. Knoblaugh, Günter J. Hämmerling, Todd Schell, Natalio Garbi, Philip D. Greenberg, 2016, Immunity on p. 389-401

T-cell immunoglobulin and ITIM domain (TIGIT) associates with CD8<sup>+</sup> T-cell exhaustion and poor clinical outcome in AML patients

Yaxian Kong, Liuluan Zhu, Todd D. Schell, Jianhong Zhang, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Melissa R. George, Hui Zeng, Hong Zheng, 2016, Clinical Cancer Research on p. 3057-3066

PD-1 <sup>hi</sup> TIM-3 <sup>+</sup> T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation

Y. Kong, J. Zhang, D. F. Claxton, W. C. Ehmann, W. B. Rybka, L. Zhu, H. Zeng, T. D. Schell, H. Zheng, 2015, Blood Cancer Journal

Improved survival and complete response rates in patients with advanced melanoma treated with concurrent ipilimumab and radiotherapy versus ipilimumab alone

Kristian M. Koller, Heath B. Mackley, Jason Liu, Henry Wagner, Giampaolo Talamo, Todd D. Schell, Colette Pameijer, Rogerio I. Neves, Bryan Anderson, Kathleen M. Kokolus, Carol A. Mallon, Joseph J. Drabick, 2017, Cancer Biology and Therapy on p. 36-42

Circulating tumor cells in melanoma patients

Gary A. Clawson, Eric Kimchi, Susan D. Patrick, Ping Xin, Ramdane Harouaka, Siyang Zheng, Arthur Berg, Todd Schell, Kevin F. Staveley-O'Carroll, Rogerio I. Neves, Paul J. Mosca, Diane Thiboutot, 2012, PLoS One on p. e41052

Randomized controlled trial of oral glutathione supplementation on body stores of glutathione

John P. Richie, Sailendra Nichenametla, Wanda Neidig, Ana Calcagnotto, Jeremy S. Haley, Todd D. Schell, Joshua E. Muscat, 2015, European Journal of Nutrition on p. 251-263

Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice

Kathleen M. Kokolus, Ying Zhang, Jeffrey M. Sivik, Carla Schmeck, Junjia Zhu, Elizabeth A. Repasky, Joseph J. Drabick, Todd D. Schell, 2018, OncoImmunology

Nanoliposome C6-ceramide increases the anti-tumor immune response and slows growth of liver tumors in mice

Guangfu Li, Dai Liu, Eric T. Kimchi, Jussuf T. Kaifi, Xiaoqiang Qi, Yariswamy Manjunath, Xinjian Liu, Tye Deering, Diego M. Avella, Todd Fox, Don C. Rockey, Todd D. Schell, Mark Kester, Kevin F. Staveley-O'Carroll, 2018, Gastroenterology on p. 1024-1036.e9

PD-1 blockade promotes epitope spreading in anticancer CD8+ T cell responses by preventing fratricidal death of subdominant clones to relieve immunodomination

Arash Memarnejadian, Courtney E. Meilleur, Christopher R. Shaler, Khashayarsha Khazaie, Jack R. Bennink, Todd D. Schell, S. M.Mansour Haeryfar, 2017, Journal of Immunology on p. 3348-3359

Regression of established hepatocellular carcinoma is induced by chemoimmunotherapy in an orthotopic murine model

Diego M. Avella, Guangfu Li, Todd D. Schell, Dai Liu, Samuel Shao Min Zhang, Xi Lou, Arthur Berg, Eric T. Kimchi, Hephzibah Rani S. Tagaram, Qing Yang, Serene Shereef, Luis S. Garcia, Mark Kester, Harriet C. Isom, C. Bart Rountree, Kevin F. Staveley-O'Carroll, 2012, Hepatology on p. 141-152