Todd Schell

Professor Microbiology & Immunology

Todd Schell

Huck Affiliations

    Immunology & Infectious Disease

Most Recent Publications

Managing telomerase and telomere dysfunction in acral melanoma

Vishnu Sravan Bollu, Yu Chi Chen, Fan Zhang, Krishne Gowda, Shantu Amin, Arun Sharma, Todd D. Schell, Jiyue Zhu, Gavin Robertson, 2025, Pharmacological Research

Cytotoxic lymphocytes induced by engineered human dendritic cells mediate potent anti-leukemia activity

Chenchen Zhao, Bei Jia, Yixing Jiang, Hiroko Shike, Charyguly Annageldiyev, Joseph Cioccio, Kentaro Minagawa, Shin Mineishi, WChristopher Ehmann, Todd D. Schell, Hua Cheng, Hong Zheng, 2025, Cancer Immunology and Immunotherapy

Current challenges and potential opportunities for interception and prevention of head and neck cancer

Karam El-Bayoumy, Neil Christensen, James Broach, Craig Meyers, Douglas Stairs, Mitchell Machtay, Jiafen Hu, Zachary T. Bitzer, Todd D. Schell, Kun-Ming Chen, Yuan-Wan Sun, Dhimant Desai, Vonn Walter, Junjia Zhu, 2025, Carcinogenesis

Optogenetically engineered Septin-7 enhances immune cell infiltration of tumor spheroids

Jiaxing Chen, Brianna Hnath, Congzhou M. Sha, Lynne Beidler, Todd D. Schell, Nikolay V. Dokholyan, 2024, Proceedings of the National Academy of Sciences of the United States of America

Tumor Heterogeneity Shapes Survival Dynamics in Drug-Treated Cells, Revealing Size-Drifting Subpopulations

Venugopal Vangala, Yu Chen, Saketh Dinavahi, Krishne Gowda, Nazir Lone, Meenhard Herlyn, Joseph Drabick, Klaus Helm, J Zhu, R Neves, Arun K. Sharma, Arthur Berg, Marco Archetti, S Amin, Todd D. Schell, Gavin P. Robertson, 2024, ACS Pharmacology and Translational Science on p. 3573-3584

Identification of Novel Isatin Derivative Bearing a Nitrofuran Moiety as Potent Multi-Isoform Aldehyde Dehydrogenase Inhibitor

Krishne Gowda, Asif Raza, Venugopal Vangala, Nazir Ahmad Lone, Jyh Ming Lin, Jaikee Kumar Singh, Sandeep Kumar Srivastava, Todd D. Schell, Gavin P. Robertson, Shantu Amin, Arun K. Sharma, 2024, Molecules

Targeting Tyro3, Axl, and MerTK Receptor Tyrosine Kinases Significantly Sensitizes Triple-Negative Breast Cancer to CDK4/6 Inhibition

S Demirsoy, H Tran, J Liu, Y Li, Shengyu Yang, Dawit Aregawi, Michael J. Glantz, N Jacob, Vonn Walter, Todd Schell, Inan Olmez, 2024, Cancers on p. 2253

Pharmacological agents targeting drug-tolerant persister cells in cancer

Yu Chi Chen, Krishne Gowda, Shantu Amin, Todd D. Schell, Arun K. Sharma, Gavin P. Robertson, 2024, Pharmacological Research

Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model

Bei Jia, Chenchen Zhao, Kentaro Minagawa, Hiroko Shike, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Shin Mineishi, Ming Wang, Todd D. Schell, K. Sandeep Prabhu, Robert F. Paulson, Yi Zhang, Leonard D. Shultz, Hong Zheng, 2023, Journal of Immunology on p. 1426-1437

Novel fourth generation-like CAR<sup>miR</sup> cells release therapeutic miRNA via exosomes and enhance glioblastoma cell killing activity

Amar Yeware, Angelica Helton, Yicheng Dong, Cheng Dong, Justin Pritchard, Kentaro Minagawa, Shin Mineishi, Todd Schell, Daniel Hayes, 2023, Biochemical Engineering Journal on p. 109068

Most-Cited Papers

Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis

Andrea Schietinger, Mary Philip, Varintra E. Krisnawan, Edison Y. Chiu, Jeffrey J. Delrow, Ryan S. Basom, Peter Lauer, Dirk G. Brockstedt, Sue E. Knoblaugh, Günter J. Hämmerling, Todd D. Schell, Natalio Garbi, Philip D. Greenberg, 2016, Immunity on p. 389-401

T-cell immunoglobulin and ITIM domain (TIGIT) associates with CD8<sup>+</sup> T-cell exhaustion and poor clinical outcome in AML patients

Yaxian Kong, Liuluan Zhu, Todd D. Schell, Jianhong Zhang, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Melissa R. George, Hui Zeng, Hong Zheng, 2016, Clinical Cancer Research on p. 3057-3066

Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice

Kathleen M. Kokolus, Ying Zhang, Jeffrey M. Sivik, Carla Schmeck, Junjia Zhu, Elizabeth A. Repasky, Joseph J. Drabick, Todd D. Schell, 2018, OncoImmunology

PD-1<sup>hi</sup>TIM-3<sup>+</sup> T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation

Y Kong, J Zhang, D. F. Claxton, W. C. Ehmann, W. B. Rybka, L Zhu, H Zeng, T. D. Schell, H. Zheng, 2015, Blood Cancer Journal on p. e330--e330

Nanoliposome C6-Ceramide Increases the Anti-tumor Immune Response and Slows Growth of Liver Tumors in Mice

Guangfu Li, Dai Liu, Eric T. Kimchi, Jussuf T. Kaifi, Xiaoqiang Qi, Yariswamy Manjunath, Xinjian Liu, Tye Deering, Diego M. Avella, Todd Fox, Don C. Rockey, Todd D. Schell, Mark Kester, Kevin F. Staveley-O'Carroll, 2018, Gastroenterology on p. 1024-1036.e9

Improved survival and complete response rates in patients with advanced melanoma treated with concurrent ipilimumab and radiotherapy versus ipilimumab alone

Kristian Koller, H Mackley, Jason Liu, H Wagner, Giampaolo Talamo, Todd D. Schell, Colette Pameijer, R Neves, Bryan Anderson, Kathleen Kokolus, Carol Mallon, Joseph J. Drabick, 2017, Cancer Biology and Therapy on p. 36-42

Randomized controlled trial of oral glutathione supplementation on body stores of glutathione

John P. Richie, Sailendra Nichenametla, Wanda Neidig, Ana Calcagnotto, Jeremy S. Haley, Todd D. Schell, Joshua E. Muscat, 2015, Zeitschrift fur Ernahrungswissenschaft on p. 251-263

Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function

R. Sinha, I. Sinha, A Calcagnotto, N Trushin, J Haley, T. D. Schell, J. P. Richie, J Richie, Jr, 2018, European Journal of Clinical Nutrition on p. 105-111

Drug-Tolerant Persister Cells in Cancer Therapy Resistance

Pavan Kumar Dhanyamraju, Todd D. Schell, Shantu Amin, Gavin P. Robertson, 2022, Cancer Research on p. 2503-2514

PD-1 blockade promotes epitope spreading in anticancer CD8+ T cell responses by preventing fratricidal death of subdominant clones to relieve immunodomination

Arash Memarnejadian, Courtney E. Meilleur, Christopher R. Shaler, Khashayarsha Khazaie, Jack R. Bennink, Todd D. Schell, S. M.Mansour Haeryfar, 2017, Journal of Immunology on p. 3348-3359