Todd Schell

Professor Microbiology & Immunology

Todd Schell

Huck Affiliations

    Immunology & Infectious Disease

Publication Tags

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T Lymphocytes Neoplasms Therapeutics Immunotherapy Survival Acute Myeloid Leukemia Radiotherapy Glutathione Melanoma Oxidative Stress Tumor Microenvironment Erythrocytes Biomarkers Growth Leukemia Liver Neoplasms Stem Cell Transplantation Allogeneic Cells Recurrence Tyrosine Immunoglobulins Nanotechnology Urinary Bladder Neoplasms Extracellular Vesicles Differentiation Antigens

Most Recent Publications

Pharmacological agents targeting drug-tolerant persister cells in cancer

Yu Chi Chen, Krishne Gowda, Shantu Amin, Todd D. Schell, Arun Sharma, Gavin Robertson, 2024, Pharmacological Research

Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model

Bei Jia, Chenchen Zhao, Kentaro Minagawa, Hiroko Shike, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Shin Mineishi, Ming Wang, Todd D. Schell, K. Sandeep Prabhu, Robert F. Paulson, Yi Zhang, Leonard D. Shultz, Hong Zheng, 2023, Journal of Immunology on p. 1426-1437

Novel fourth generation-like CAR<sup>miR</sup> cells release therapeutic miRNA via exosomes and enhance glioblastoma cell killing activity

Amar Yeware, Angelica Helton, Yicheng Dong, Cheng Dong, Justin Pritchard, Shin Mineishi, Kentaro Minagawa, Todd Schell, Daniel Hayes, 2023, Biochemical Engineering Journal

Complementarity between Microbiome and Immunity May Account for the Potentiating Effect of Quercetin on the Antitumor Action of Cyclophosphamide in a Triple-Negative Breast Cancer Model

Andrea Manni, Yuan Wan Sun, Todd D. Schell, Tymofiy Lutsiv, Henry Thompson, Kun Ming Chen, Cesar Aliaga, Junjia Zhu, Karam El-Bayoumy, 2023, Pharmaceuticals

Sexually dimorphic effect of H-ferritin genetic manipulation on survival and tumor microenvironment in a mouse model of glioblastoma

Bhavyata Pandya Shesh, Vonn Walter, Kondaiah Palsa, Becky Slagle-Webb, Elizabeth Neely, Todd Schell, James R. Connor, 2023, Journal of Neuro-Oncology on p. 569-586

Concurrent durvalumab and radiation therapy (DUART) followed by adjuvant durvalumab in patients with localized urothelial cancer of bladder: Results from phase II study, BTCRC-GU15-023

Monika Joshi, Leonard Tuanquin, J Zhu, Vonn Walter, Todd Schell, Matthew Kaag, Deepak Kilari, Jiangang Liao, S Holder, Hamid Emamekhoo, A Sankin, S Merrill, Hong Zheng, Joshua Warrick, R Hauke, Benjamin Gartrel, B Gartel, M Stein, Joseph Drabick, David J. Degraff, Y Zakharia, 2023, Journal for ImmunoTherapy of Cancer

IGF2BP family of RNA-binding proteins regulate innate and adaptive immune responses in cancer cells and tumor microenvironment

Irina A. Elcheva, Chethana P. Gowda, Daniel Bogush, Svetlana Gornostaeva, Anna Fakhardo, Neil Sheth, Kathleen M. Kokolus, Arati Sharma, Sinisa Dovat, Yasin Uzun, Todd D. Schell, Vladimir S. Spiegelman, 2023, Frontiers in Immunology

Immune Responses in Oral Papillomavirus Clearance in the MmuPV1 Mouse Model

Sarah A. Brendle, Jingwei J. Li, Vonn Walter, Todd Schell, Michael Kozak, Karla K. Balogh, Song Lu, Neil D. Christensen, Yusheng Zhu, Karam El-Bayoumy, Jiafen Hu, 2023, Pathogens on p. 1452

Drug-Tolerant Persister Cells in Cancer Therapy Resistance

Pavan Kumar Dhanyamraju, Todd D. Schell, Shantu Amin, Gavin P. Robertson, 2022, Cancer Research on p. 2503-2514

Small extracellular vesicles induce resistance to anti-GD2 immunotherapy unveiling tipifarnib as an adjunct to neuroblastoma immunotherapy

Xiaoming Liu, Carson A. Wills, Longgui Chen, Jiawen Zhang, Yuanjun Zhao, Mi Zhou, Jeffrey Sundstrom, Todd Schell, Vladimir S. Spiegelman, Megan M. Young, Hong Gang Wang, 2022, Journal for ImmunoTherapy of Cancer

Most-Cited Papers

Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis

Andrea Schietinger, Mary Philip, Varintra E. Krisnawan, Edison Y. Chiu, Jeffrey J. Delrow, Ryan S. Basom, Peter Lauer, Dirk G. Brockstedt, Sue E. Knoblaugh, Günter J. Hämmerling, Todd D. Schell, Natalio Garbi, Philip D. Greenberg, 2016, Immunity on p. 389-401

T-cell immunoglobulin and ITIM domain (TIGIT) associates with CD8<sup>+</sup> T-cell exhaustion and poor clinical outcome in AML patients

Yaxian Kong, Liuluan Zhu, Todd D. Schell, Jianhong Zhang, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Melissa R. George, Hui Zeng, Hong Zheng, 2016, Clinical Cancer Research on p. 3057-3066

PD-1<sup>hi</sup>TIM-3<sup>+</sup> T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation

Y Kong, J Zhang, D. F. Claxton, W. C. Ehmann, W. B. Rybka, L Zhu, H Zeng, T. D. Schell, H. Zheng, 2015, Blood Cancer Journal on p. e330--e330

Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice

Kathleen M. Kokolus, Ying Zhang, Jeffrey M. Sivik, Carla Schmeck, Junjia Zhu, Elizabeth A. Repasky, Joseph J. Drabick, Todd D. Schell, 2018, OncoImmunology

Improved survival and complete response rates in patients with advanced melanoma treated with concurrent ipilimumab and radiotherapy versus ipilimumab alone

Kristian Koller, H Mackley, Jason Liu, H Wagner, Giampaolo Talamo, Todd D. Schell, Colette Pameijer, R Neves, Bryan Anderson, Kathleen Kokolus, Carol Mallon, Joseph J. Drabick, 2017, Cancer Biology and Therapy on p. 36-42

Nanoliposome C6-Ceramide Increases the Anti-tumor Immune Response and Slows Growth of Liver Tumors in Mice

Guangfu Li, Dai Liu, Eric T. Kimchi, Jussuf T. Kaifi, Xiaoqiang Qi, Yariswamy Manjunath, Xinjian Liu, Tye Deering, Diego M. Avella, Todd Fox, Don C. Rockey, Todd D. Schell, Mark Kester, Kevin F. Staveley-O'Carroll, 2018, Gastroenterology on p. 1024-1036.e9

Randomized controlled trial of oral glutathione supplementation on body stores of glutathione

John P. Richie, Sailendra Nichenametla, Wanda Neidig, Ana Calcagnotto, Jeremy S. Haley, Todd D. Schell, Joshua E. Muscat, 2015, Zeitschrift fur Ernahrungswissenschaft on p. 251-263

Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function

R. Sinha, I. Sinha, A Calcagnotto, N Trushin, J Haley, T. D. Schell, J. P. Richie, J Richie, Jr, 2018, European Journal of Clinical Nutrition on p. 105-111

PD-1 blockade promotes epitope spreading in anticancer CD8+ T cell responses by preventing fratricidal death of subdominant clones to relieve immunodomination

Arash Memarnejadian, Courtney E. Meilleur, Christopher R. Shaler, Khashayarsha Khazaie, Jack R. Bennink, Todd D. Schell, S. M.Mansour Haeryfar, 2017, Journal of Immunology on p. 3348-3359

Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia

Liuluan Zhu, Yaxian Kong, Jianhong Zhang, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Neil D. Palmisiano, Ming Wang, Bei Jia, Michael Bayerl, Todd D. Schell, Raymond J. Hohl, Hui Zeng, Hong Zheng, 2017, Journal of Hematology and Oncology on p. 124