Timothy Meredith

Assistant Professor of Biochemistry and Molecular Biology

Timothy Meredith

Research Summary

Understanding how bacterial cell surface complex lipids are synthesized, to characterize structural modifications in response to varying growth environments, and to uncover how these changes are regulated.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Anti Bacterial Agents Staphylococcus Aureus Genes Lactams Lipopolysaccharides Beta Lactams Lipoproteins Membranes Methicillin Resistant Staphylococcus Aureus Teichoic Acids Pharmaceutical Preparations Recombinant Proteins Acylation Escherichia Coli Lipoteichoic Acid Genome Toll Like Receptor 2 Alkaline Phosphatase Methicillin Resistance Moenomycin Endotoxins Methicillin Escherichia Coli Endotoxin Bacteria Libraries

Most Recent Papers

Bacterial lyso-form lipoproteins are synthesized via an intramolecular acyl chain migration

Krista M. Armbruster, Gloria Komazin, Timothy C. Meredith, 2020, Journal of Biological Chemistry on p. 10195-10211

Lipoprotein n-acylation in staphylococcus aureus is catalyzed by a two-component acyl transferase system

John H. Gardiner, Gloria Komazin, Miki Matsuo, Kaitlin Cole, Friedrich Götz, Timothy C. Meredith, 2020, mBio on p. 1-18

Substrate structure-activity relationship reveals a limited lipopolysaccharide chemotype range for intestinal alkaline phosphatase

Gloria Komazin, Michael Maybin, Ronald W. Woodard, Thomas Scior, Dominik Schwudke, Ursula Schombel, Nicolas Gisch, Uwe Mamat, Timothy C. Meredith, 2019, Journal of Biological Chemistry on p. 19405-19423

Copper-Induced Expression of a Transmissible Lipoprotein Intramolecular Transacylase Alters Lipoprotein Acylation and the Toll-Like Receptor 2 Response to Listeria monocytogenes

Krista M. Armbruster, Gloria Komazin-Meredith, Timothy Charles Meredith, 2019, Journal of Bacteriology

Multi-strain Tn-Seq reveals common daptomycin resistance determinants in Staphylococcus aureus

Kathryn A. Coe, Wonsik Lee, Madeleine C. Stone, Gloria Komazin-Meredith, Timothy C. Meredith, Yonatan H. Grad, Suzanne Walker, 2019, PLoS Pathogens

Streptococcus gordonii Type I lipoteichoic acid contributes to surface protein biogenesis

Bruno P. Lima, Kelvin Kho, Brittany L. Nairn, Gunnel Svensäter, Ruoqiong Chen, Amanda Steffes, Gerrit W. Vreeman, Timothy C. Meredith, Mark C. Herzberg, 2019, mSphere

Cell-based screen for discovering lipopolysaccharide biogenesis inhibitors

Ge Zhang, Vadim Baidin, Karanbir S. Pahil, Eileen Moison, David Tomasek, Nitya S. Ramadoss, Arnab K. Chatterjee, Case W. McNamara, Travis S. Young, Peter G. Schultz, Timothy Charles Meredith, Daniel Kahne, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. 6834-6839

Antibiotic Combinations That Enable One-Step, Targeted Mutagenesis of Chromosomal Genes

Wonsik Lee, Truc Do, Ge Zhang, Daniel Kahne, Timothy Charles Meredith, Suzanne Walker, 2018, ACS Infectious Diseases on p. 1007-1018

Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic article

Marina Santiago, Wonsik Lee, Antoine Abou Fayad, Kathryn A. Coe, Mithila Rajagopal, Truc Do, Fabienne Hennessen, Veerasak Srisuknimit, Rolf Müller, Timothy Charles Meredith, Suzanne Walker, 2018, Nature Chemical Biology on p. 601-608

Saltinduced stress stimulates a lipoteichoic acidspecific three-component glycosylation system in Staphylococcus aureus

Kelvin Kho, Timothy C. Meredith, 2018, Journal of Bacteriology

Most-Cited Papers

Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics.

C Tan, A Therien, J Lu, S Lee, A Caron, C Gill, C Lebeau-Jacob, L Benton-Perdomo, J Monteiro, P Pereira, N Elsen, J Wu, K Deschamps, M Petcu, S Wong, E Daigneault, S Kramer, L Liang, E Maxwell, D Claveau, J Vaillancourt, K Skorey, J Tam, H Wang, Timothy Meredith, S Sillaots, L Wang-Jarantow, Y Ramtohul, E Langlois, F Landry, J Reid, G Parthasarathy, S Sharma, A Baryshnikova, K Lumb, M Pinho, S Soisson, T Roemer, 2012, Science Translational Medicine on p. 126ra35

Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids

Stephanie Brown, Guoqing Xia, Lyly G. Luhachack, Jennifer Campbell, Timothy C. Meredith, Calvin Chen, Volker Winstel, Cordula Gekeler, Javier E. Irazoqui, Andreas Peschel, Suzanne Walker, 2012, Proceedings of the National Academy of Sciences of the United States of America on p. 18909-18914

On the essentiality of lipopolysaccharide to Gram-negative bacteria

Ge Zhang, Timothy C. Meredith, Daniel Kahne, 2013, Current Opinion in Microbiology on p. 779-785

Detoxifying Escherichia coli for endotoxin-free production of recombinant proteins

Uwe Mamat, Kathleen Wilke, David Bramhill, Andra Beate Schromm, Buko Lindner, Thomas Andreas Kohl, José Luis Corchero, Antonio Villaverde, Lana Schaffer, Steven Robert Head, Chad Souvignier, Timothy Charles Meredith, Ronald Wesley Woodard, 2015, Microbial Cell Factories

Discovery of wall teichoic acid inhibitors as potential anti-MRSA β-lactam combination agents

Hao Wang, Charles J. Gill, Sang H. Lee, Paul Mann, Paul Zuck, Timothy C. Meredith, Nicholas Murgolo, Xinwei She, Susan Kales, Lianzhu Liang, Jenny Liu, Jin Wu, John Santa Maria, Jing Su, Jianping Pan, Judy Hailey, Debra McGuinness, Christopher M. Tan, Amy Flattery, Suzanne Walker, Todd Black, Terry Roemer, 2013, Cell Chemical Biology on p. 272-284

Antagonism of chemical genetic interaction networks resensitize MRSA to β-lactam antibiotics

Sang Ho Lee, Lisa Wang Jarantow, Hao Wang, Susan Sillaots, Henry Cheng, Timothy C. Meredith, John Thompson, Terry Roemer, 2011, Cell Chemical Biology on p. 1379-1389

A new platform for ultra-high density Staphylococcus aureus transposon libraries

Marina Santiago, Leigh M. Matano, Samir H. Moussa, Michael S. Gilmore, Suzanne Walker, Timothy C. Meredith, 2015, BMC Genomics

Fatty acid biosynthesis in Pseudomonas aeruginosa is initiated by the faby class of β-ketoacyl acyl carrier protein synthases

Yanqiu Yuan, Meena Sachdeva, Jennifer A. Leeds, Timothy Charles Meredith, 2012, Journal of Bacteriology on p. 5171-5184

Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin.

Roman Makitrynskyy, Bohdan Ostash, Olga Tsypik, Yuriy Rebets, Emma Doud, Timothy Meredith, Andriy Luzhetskyy, Andreas Bechthold, Suzanne Walker, Victor Fedorenko, 2013, Open Biology on p. 130121

High-frequency transposition for determining antibacterial mode of action

Hao Wang, David Claveau, John P. Vaillancourt, Terry Roemer, Timothy Charles Meredith, 2011, Nature Chemical Biology on p. 720-729