Timothy Meredith

Assistant Professor of Biochemistry and Molecular Biology

Timothy Meredith

Research Summary

Understanding how bacterial cell surface complex lipids are synthesized, to characterize structural modifications in response to varying growth environments, and to uncover how these changes are regulated.

Graduate Students

Huck Affiliations


Publication Tags

Anti Bacterial Agents Teichoic Acids Staphylococcus Aureus Lipopolysaccharides Beta Lactams Lipoproteins Lactams Genes Membranes Mass Spectrometry Recombinant Proteins Methicillin Resistant Staphylococcus Aureus Adenosine Triphosphatases Pharmaceutical Preparations Proteins Lipoteichoic Acid Escherichia Coli Alkaline Phosphatase Escherichia Coli Endotoxin Methicillin Atp Binding Cassette Transporters Moenomycin Lipopeptides Endotoxins Fluorescent Dyes

Most Recent Papers

Streptococcus gordonii Type I lipoteichoic acid contributes to surface protein biogenesis

Bruno P. Lima, Kelvin Kho, Brittany L. Nairn, Gunnel Svensäter, Ruoqiong Chen, Amanda Steffes, Gerrit W. Vreeman, Timothy C. Meredith, Mark C. Herzberg, 2019, mSphere

Multi-strain Tn-Seq reveals common daptomycin resistance determinants in Staphylococcus aureus

Kathryn A. Coe, Wonsik Lee, Madeleine C. Stone, Gloria Komazin-Meredith, Timothy C. Meredith, Yonatan H. Grad, Suzanne Walker, 2019, PLoS pathogens

Substrate structure-activity relationship reveals a limited lipopolysaccharide chemotype range for intestinal alkaline phosphatase

Gloria Komazin, Michael Maybin, Ronald W. Woodard, Thomas Scior, Dominik Schwudke, Ursula Schombel, Nicolas Gisch, Uwe Mamat, Timothy C. Meredith, 2019, Journal of Biological Chemistry on p. 19405-19423

Copper-Induced Expression of a Transmissible Lipoprotein Intramolecular Transacylase Alters Lipoprotein Acylation and the Toll-Like Receptor 2 Response to Listeria monocytogenes

Krista M. Armbruster, Gloria Komazin-Meredith, Timothy Charles Meredith, 2019, Journal of bacteriology

Saltinduced stress stimulates a lipoteichoic acidspecific three-component glycosylation system in Staphylococcus aureus

Kelvin Kho, Timothy C. Meredith, 2018, Journal of bacteriology

Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic article

Marina Santiago, Wonsik Lee, Antoine Abou Fayad, Kathryn A. Coe, Mithila Rajagopal, Truc Do, Fabienne Hennessen, Veerasak Srisuknimit, Rolf Müller, Timothy Charles Meredith, Suzanne Walker, 2018, Nature Chemical Biology on p. 601-608

Enrichment of bacterial lipoproteins and preparation of n-terminal lipopeptides for structural determination by mass spectrometry

Krista M. Armbruster, Timothy C. Meredith, 2018, Journal of Visualized Experiments

Antibiotic That Inhibits the ATPase Activity of an ATP-Binding Cassette Transporter by Binding to a Remote Extracellular Site

Leigh M. Matano, Heidi G. Morris, Anthony R. Hesser, Sara E.S. Martin, Wonsik Lee, Tristan W. Owens, Emaline Laney, Hidemasa Nakaminami, David Hooper, Timothy Charles Meredith, Suzanne Walker, 2017, Journal of the American Chemical Society on p. 10597-10600

Identification of the lyso-form N-acyl intramolecular transferase in low-GC firmicutes

Krista M. Armbruster, Timothy C. Meredith, 2017, Journal of bacteriology

A Fluorescent Probe Distinguishes between Inhibition of Early and Late Steps of Lipopolysaccharide Biogenesis in Whole Cells

Eileen Moison, Ran Xie, Ge Zhang, Matthew D. Lebar, Timothy C. Meredith, Daniel Kahne, 2017, ACS chemical biology on p. 928-932

Most-Cited Papers

Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics

Christopher M. Tan, Alex G. Therien, Jun Lu, Sang H. Lee, Alexandre Caron, Charles J. Gill, Christian Lebeau-Jacob, Liliana Benton-Perdomo, João M. Monteiro, Pedro M. Pereira, Nathaniel L. Elsen, Jin Wu, Kathleen Deschamps, Mihai Petcu, Simon Wong, Etienne Daigneault, Susanne Kramer, Lianzhu Liang, Eugene Maxwell, David Claveau, John Vaillancourt, Kathryn Skorey, John Tam, Hao Wang, Timothy C. Meredith, Susan Sillaots, Lisa Wang-Jarantow, Yeeman Ramtohul, Eric Langlois, France Landry, John C. Reid, Gopal Parthasarathy, Sujata Sharma, Anastasia Baryshnikova, Kevin J. Lumb, Mariana G. Pinho, Stephen M. Soisson, Terry Roemer, 2012, Science Translational Medicine

Discovery of wall teichoic acid inhibitors as potential anti-MRSA β-lactam combination agents

Hao Wang, Charles J. Gill, Sang H. Lee, Paul Mann, Paul Zuck, Timothy C. Meredith, Nicholas Murgolo, Xinwei She, Susan Kales, Lianzhu Liang, Jenny Liu, Jin Wu, John Santa Maria, Jing Su, Jianping Pan, Judy Hailey, Debra McGuinness, Christopher M. Tan, Amy Flattery, Suzanne Walker, Todd Black, Terry Roemer, 2013, Chemistry and Biology on p. 272-284

Detoxifying Escherichia coli for endotoxin-free production of recombinant proteins

Uwe Mamat, Kathleen Wilke, David Bramhill, Andra Beate Schromm, Buko Lindner, Thomas Andreas Kohl, José Luis Corchero, Antonio Villaverde, Lana Schaffer, Steven Robert Head, Chad Souvignier, Timothy Charles Meredith, Ronald Wesley Woodard, 2015, Microbial Cell Factories

Antagonism of chemical genetic interaction networks resensitize MRSA to β-lactam antibiotics

Sang Ho Lee, Lisa Wang Jarantow, Hao Wang, Susan Sillaots, Henry Cheng, Timothy C. Meredith, John Thompson, Terry Roemer, 2011, Chemistry and Biology on p. 1379-1389

High-frequency transposition for determining antibacterial mode of action

Hao Wang, David Claveau, John P. Vaillancourt, Terry Roemer, Timothy Charles Meredith, 2011, Nature Chemical Biology on p. 720-729

A new platform for ultra-high density Staphylococcus aureus transposon libraries

Marina Santiago, Leigh M. Matano, Samir H. Moussa, Michael S. Gilmore, Suzanne Walker, Timothy C. Meredith, 2015, BMC genomics

Pseudomonas aeruginosa directly shunts β-oxidation degradation intermediates into de novo fatty acid biosynthesis

Yanqiu Yuan, Jennifer A. Leeds, Timothy C. Meredith, 2012, Journal of bacteriology on p. 5185-5196

Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin.

Roman Makitrynskyy, Bohdan Ostash, Olga Tsypik, Yuriy Rebets, Emma Doud, Timothy Meredith, Andriy Luzhetskyy, Andreas Bechthold, Suzanne Walker, Victor Fedorenko, 2013, Open biology

A synthetic lethal approach for compound and target identification in Staphylococcus aureus

Lincoln Pasquina, John P. Santa Maria, B. McKay Wood, Samir H. Moussa, Leigh M. Matano, Marina Santiago, Sara E.S. Martin, Wonsik Lee, Timothy C. Meredith, Suzanne Walker, 2016, Nature Chemical Biology on p. 40-45

Staphylococcus aureus and bacillus subtilis W23 make polyribitol wall teichoic acids using different enzymatic pathways

Stephanie Brown, Timothy Meredith, Jonathan Swoboda, Suzanne Walker, 2010, Chemistry and Biology on p. 1101-1110