Timothy Meredith

Associate Professor of Biochemistry and Molecular Biology

Timothy Meredith

Research Summary

Understanding how bacterial cell surface complex lipids are synthesized, to characterize structural modifications in response to varying growth environments, and to uncover how these changes are regulated.

Huck Graduate Students

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Staphylococcus Aureus Genes Anti Bacterial Agents Lipopolysaccharides Lipoproteins Lipoteichoic Acid Membranes Proteins Listeria Monocytogenes Libraries Teichoic Acids Copper Recombinant Proteins Acylation Lactams Toll Like Receptor 2 Alkaline Phosphatase Escherichia Coli Bacteria Daptomycin Escherichia Coli Endotoxin Beta Lactams Endotoxins Moenomycin Genome

Most Recent Publications

A Copper-Responsive Two-Component System Governs Lipoprotein Remodeling in Listeria monocytogenes

Gloria Meredith, G Komazin, A Rizk, K Armbruster, V Bonnell, Manuel Llinas, Manuel Llinás, Timothy Meredith, 2023, Journal of Bacteriology on p. e0039022

The Extracellular Electron Transport Pathway Reduces Copper for Sensing by the CopRS Two-Component System under Anaerobic Conditions in Listeria monocytogenes

A Rizk, G Komazin, Gloria Meredith, M Maybin, N Hoque, Hoque Nushrat, Emily Weinert, Timothy Meredith, 2023, Journal of Bacteriology on p. e00391-22

Rapid Inhibitor Discovery by Exploiting Synthetic Lethality

Jacob D. Muscato, Heidi G. Morris, Aaron Mychack, Mithila Rajagopal, Vadim Baidin, Anthony R. Hesser, Wonsik Lee, Kemal İnecik, Laura J. Wilson, Christina M. Kraml, Timothy C. Meredith, Suzanne Walker, 2022, Journal of the American Chemical Society on p. 3696-3705

Spatial regulation of protein A in Staphylococcus aureus

Ran Zhang, Mac A. Shebes, Kelvin Kho, Salvatore J. Scaffidi, Timothy C. Meredith, Wenqi Yu, 2021, Molecular Microbiology on p. 589-605

Bacterial lyso-form lipoproteins are synthesized via an intramolecular acyl chain migration

Krista M. Armbruster, Gloria Komazin, Timothy C. Meredith, 2020, Journal of Biological Chemistry on p. 10195-10211

Lipoprotein n-acylation in staphylococcus aureus is catalyzed by a two-component acyl transferase system

John H. Gardiner, Gloria Komazin, Miki Matsuo, Kaitlin Cole, Friedrich Götz, Timothy C. Meredith, 2020, mBio on p. 1-18

Streptococcus gordonii Type I lipoteichoic acid contributes to surface protein biogenesis

Bruno P. Lima, Kelvin Kho, Brittany L. Nairn, Gunnel Svensäter, Ruoqiong Chen, Amanda Steffes, Gerrit W. Vreeman, Timothy C. Meredith, Mark C. Herzberg, 2019, mSphere

Copper-Induced Expression of a Transmissible Lipoprotein Intramolecular Transacylase Alters Lipoprotein Acylation and the Toll-Like Receptor 2 Response to Listeria monocytogenes

Krista M. Armbruster, Gloria Komazin, Timothy C. Meredith, 2019, Journal of Bacteriology

Substrate structure-activity relationship reveals a limited lipopolysaccharide chemotype range for intestinal alkaline phosphatase

Gloria Komazin, Michael Maybin, Ronald W. Woodard, Thomas Scior, Dominik Schwudke, Ursula Schombel, Nicolas Gisch, Uwe Mamat, Timothy C. Meredith, 2019, Journal of Biological Chemistry on p. 19405-19423

Multi-strain Tn-Seq reveals common daptomycin resistance determinants in Staphylococcus aureus

Kathryn A. Coe, Wonsik Lee, Madeleine C. Stone, Gloria Komazin-Meredith, Timothy C. Meredith, Yonatan H. Grad, Suzanne Walker, 2019, PLoS Pathogens

Most-Cited Papers

On the essentiality of lipopolysaccharide to Gram-negative bacteria

Ge Zhang, Timothy C. Meredith, Daniel Kahne, 2013, Current Opinion in Microbiology on p. 779-785

Detoxifying Escherichia coli for endotoxin-free production of recombinant proteins

Uwe Mamat, Kathleen Wilke, David Bramhill, Andra Beate Schromm, Buko Lindner, Thomas Andreas Kohl, José Luis Corchero, Antonio Villaverde, Lana Schaffer, Steven Robert Head, Chad Souvignier, Timothy Charles Meredith, Ronald Wesley Woodard, 2015, Microbial Cell Factories

Discovery of wall teichoic acid inhibitors as potential anti-MRSA β-lactam combination agents

Hao Wang, Charles J. Gill, Sang H. Lee, Paul Mann, Paul Zuck, Timothy C. Meredith, Nicholas Murgolo, Xinwei She, Susan Kales, Lianzhu Liang, Jenny Liu, Jin Wu, John Santa Maria, Jing Su, Jianping Pan, Judy Hailey, Debra McGuinness, Christopher M. Tan, Amy Flattery, Suzanne Walker, Todd Black, Terry Roemer, 2013, Cell Chemical Biology on p. 272-284

Cell-based screen for discovering lipopolysaccharide biogenesis inhibitors

Ge Zhang, Vadim Baidin, Karanbir S. Pahil, Eileen Moison, David Tomasek, Nitya S. Ramadoss, Arnab K. Chatterjee, Case W. McNamara, Travis S. Young, Peter G. Schultz, Timothy C. Meredith, Daniel Kahne, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. 6834-6839

A new platform for ultra-high density Staphylococcus aureus transposon libraries

Marina Santiago, Leigh M. Matano, Samir H. Moussa, Michael S. Gilmore, Suzanne Walker, Timothy C. Meredith, 2015, BMC Genomics

A synthetic lethal approach for compound and target identification in Staphylococcus aureus

Lincoln Pasquina, John P. Santa Maria, B. McKay Wood, Samir H. Moussa, Leigh M. Matano, Marina Santiago, Sara E.S. Martin, Wonsik Lee, Timothy C. Meredith, Suzanne Walker, 2016, Nature Chemical Biology on p. 40-45

Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin.

Roman Makitrynskyy, Bohdan Ostash, Olga Tsypik, Yuriy Rebets, Emma Doud, Timothy Meredith, Andriy Luzhetskyy, Andreas Bechthold, Suzanne Walker, Victor Fedorenko, 2013, Open Biology on p. 130121

Multidrug intrinsic resistance factors in Staphylococcus aureus identified by profiling fitness within high-diversity transposon libraries

Mithila Rajagopal, Melissa J. Martin, Marina Santiago, Wonsik Lee, Veronica N. Kos, Tim Meredith, Michael S. Gilmore, Suzanne Walker, 2016, mBio

Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic article

Marina Santiago, Wonsik Lee, Antoine Abou Fayad, Kathryn A. Coe, Mithila Rajagopal, Truc Do, Fabienne Hennessen, Veerasak Srisuknimit, Rolf Müller, Timothy C. Meredith, Suzanne Walker, 2018, Nature Chemical Biology on p. 601-608

Multi-strain Tn-Seq reveals common daptomycin resistance determinants in Staphylococcus aureus

Kathryn A. Coe, Wonsik Lee, Madeleine C. Stone, Gloria Komazin-Meredith, Timothy C. Meredith, Yonatan H. Grad, Suzanne Walker, 2019, PLoS Pathogens