Thomas Spratt
Associate Professor or Biochemistry
-
Hershey Med Ctr
Hershey, - tes13@psu.edu
Huck Affiliations
Most Recent Publications
Translesion-synthesis-mediated bypass of DNA lesions occurs predominantly behind replication forks restarted by PrimPol
Ashna Dhoonmoon, Julia R. Ambrose, Sonal Garg, Cynthia Lascarez-Espana, Abbey Rebok, Thomas E. Spratt, George Lucian Moldovan, Claudia M. Nicolae, 2025, Cell Reports
Catalytic-Dependent Role of DNA Polymerase κ in Nucleotide Excision Repair
Abbey Rebok, Mariela C. Torres, Julia R. Ambrose, Thomas E. Spratt, 2025, Chemical Research in Toxicology
Activity of DNA polymerase κ across the genome in human fibroblasts
Mariela C. Torres, Abbey Rebok, Dongxiao Sun, Thomas E. Spratt, 2024, Proceedings of the National Academy of Sciences of the United States of America
Stephen S. Hecht Has Played a Major Role in Investigating Tobacco Carcinogenesis
Thomas E. Spratt, 2023, Chemical Research in Toxicology on p. 563-564
Unique DNA Polymerase kappa Interactome Suggests Novel Cellular Functions
Shilpi Paul, Paolo Cifani, Darryl Pappin, Thomas Spratt, 2022, FASEB Journal
Active Site Interactions Impact Phosphoryl Transfer during Replication of Damaged and Undamaged DNA by Escherichia coli DNA Polymerase i
A. S. Prakasha Gowda, Thomas E. Spratt, 2017, Chemical Research in Toxicology on p. 2033-2043
Mutagenic Replication of N<sup>2</sup>-Deoxyguanosine Benzo[a]pyrene Adducts by Escherichia coli DNA Polymerase i and Sulfolobus solfataricus DNA Polymerase IV
A. S.Prakasha Gowda, Jacek Krzeminski, Shantu Amin, Zucai Suo, Thomas E. Spratt, 2017, Chemical Research in Toxicology on p. 1168-1176
N<sup>2</sup>-Substituted 2′-Deoxyguanosine Triphosphate Derivatives as Selective Substrates for Human DNA Polymerase κ
A. S.Prakasha Gowda, Marietta Lee, Thomas E. Spratt, 2017, Angewandte Chemie - International Edition on p. 2628-2631
Honokiol Inhibits DNA Polymerases β and λ and Increases Bleomycin Sensitivity of Human Cancer Cells
A. S.Prakasha Gowda, Zucai Suo, Thomas E. Spratt, 2017, Chemical Research in Toxicology on p. 715-725
DNA Polymerase ν Rapidly Bypasses O<sup>6</sup>-Methyl-dG but Not O<sup>6</sup>-[4-(3-Pyridyl)-4-oxobutyl-dG and O<sup>2</sup>-Alkyl-dTs
A. S.Prakasha Gowda, Thomas E. Spratt, 2016, Chemical Research in Toxicology on p. 1894-1900
Most-Cited Papers
Roles of translesion synthesis DNA polymerases in the potent mutagenicity of tobacco-specific nitrosamine-derived O<sup>2</sup>-alkylthymidines in human cells
Savithri Weerasooriya, Vijay P. Jasti, Arindam Bose, Thomas E. Spratt, Ashis K. Basu, 2015, DNA Repair on p. 63-70
Honokiol Inhibits DNA Polymerases β and λ and Increases Bleomycin Sensitivity of Human Cancer Cells
A. S.Prakasha Gowda, Zucai Suo, Thomas E. Spratt, 2017, Chemical Research in Toxicology on p. 715-725
N<sup>2</sup>-Substituted 2′-Deoxyguanosine Triphosphate Derivatives as Selective Substrates for Human DNA Polymerase κ
A. S.Prakasha Gowda, Marietta Lee, Thomas E. Spratt, 2017, Angewandte Chemie - International Edition on p. 2628-2631
DNA Polymerases η and ζ Combine to Bypass O<sup>2</sup>-[4-(3-Pyridyl)-4-oxobutyl]thymine, a DNA Adduct Formed from Tobacco Carcinogens
A. S. Prakasha Gowda, Thomas E. Spratt, 2016, Chemical Research in Toxicology on p. 303-316
Human DNA polymerase ν catalyzes correct and incorrect DNA synthesis with high catalytic efficiency
A. S.Prakasha Gowda, George Lucian Moldovan, Thomas E. Spratt, 2015, Journal of Biological Chemistry on p. 16292-16303
DNA Polymerase ν Rapidly Bypasses O<sup>6</sup>-Methyl-dG but Not O<sup>6</sup>-[4-(3-Pyridyl)-4-oxobutyl-dG and O<sup>2</sup>-Alkyl-dTs
A. S.Prakasha Gowda, Thomas E. Spratt, 2016, Chemical Research in Toxicology on p. 1894-1900
Activity of DNA polymerase κ across the genome in human fibroblasts
Mariela C. Torres, Abbey Rebok, Dongxiao Sun, Thomas E. Spratt, 2024, Proceedings of the National Academy of Sciences of the United States of America
Mutagenic Replication of N<sup>2</sup>-Deoxyguanosine Benzo[a]pyrene Adducts by Escherichia coli DNA Polymerase i and Sulfolobus solfataricus DNA Polymerase IV
A. S.Prakasha Gowda, Jacek Krzeminski, Shantu Amin, Zucai Suo, Thomas E. Spratt, 2017, Chemical Research in Toxicology on p. 1168-1176
Translesion-synthesis-mediated bypass of DNA lesions occurs predominantly behind replication forks restarted by PrimPol
Ashna Dhoonmoon, Julia R. Ambrose, Sonal Garg, Cynthia Lascarez-Espana, Abbey Rebok, Thomas E. Spratt, George Lucian Moldovan, Claudia M. Nicolae, 2025, Cell Reports
Active Site Interactions Impact Phosphoryl Transfer during Replication of Damaged and Undamaged DNA by Escherichia coli DNA Polymerase i
A. S. Prakasha Gowda, Thomas E. Spratt, 2017, Chemical Research in Toxicology on p. 2033-2043