Thomas Spratt

Associate Professor or Biochemistry

Thomas Spratt

Huck Affiliations

Publication Tags

Dna Directed Dna Polymerase Tobacco Dna Nitrosamines Carcinogens Dna Adducts Escherichia Coli Thymidine 5' Triphosphate 4 (N Methyl N Nitrosamino) 1 (3 Pyridyl) 1 Butanone Deoxyguanosine Triphosphate Human Dna Polymerase N Thymine Dna Polymerase Beta Nucleotides Cells Dna Polymerase Zeta N' Nitrosonornicotine Rad30 Protein Thymidine Substrates O2 (4 (3 Pyridyl) 4 Oxobut 1 Yl)Thymidine Base Pairing Neoplasms 2' Deoxycytidine 5' Triphosphate Derivatives

Most Recent Papers

Active Site Interactions Impact Phosphoryl Transfer during Replication of Damaged and Undamaged DNA by Escherichia coli DNA Polymerase i

A. S. Prakasha Gowda, Thomas E. Spratt, 2017, Chemical Research in Toxicology on p. 2033-2043

Mutagenic Replication of N<sup>2</sup>-Deoxyguanosine Benzo[a]pyrene Adducts by Escherichia coli DNA Polymerase i and Sulfolobus solfataricus DNA Polymerase IV

A. S.Prakasha Gowda, Jacek Krzeminski, Shantu Amin, Zucai Suo, Thomas E. Spratt, 2017, Chemical Research in Toxicology on p. 1168-1176

N<sup>2</sup>-Substituted 2′-Deoxyguanosine Triphosphate Derivatives as Selective Substrates for Human DNA Polymerase κ

A. S.Prakasha Gowda, Marietta Lee, Thomas E. Spratt, 2017, Angewandte Chemie - International Edition on p. 2628-2631

Honokiol Inhibits DNA Polymerases β and λ and Increases Bleomycin Sensitivity of Human Cancer Cells

A. S.Prakasha Gowda, Zucai Suo, Thomas E. Spratt, 2017, Chemical Research in Toxicology on p. 715-725

DNA Polymerase ν Rapidly Bypasses O<sup>6</sup>-Methyl-dG but Not O<sup>6</sup>-[4-(3-Pyridyl)-4-oxobutyl-dG and O<sup>2</sup>-Alkyl-dTs

A. S.Prakasha Gowda, Thomas E. Spratt, 2016, Chemical Research in Toxicology on p. 1894-1900

DNA Polymerases η and ζ Combine to Bypass O<sup>2</sup>-[4-(3-Pyridyl)-4-oxobutyl]thymine, a DNA Adduct Formed from Tobacco Carcinogens

A. S. Prakasha Gowda, Thomas E. Spratt, 2016, Chemical Research in Toxicology on p. 303-316

Roles of translesion synthesis DNA polymerases in the potent mutagenicity of tobacco-specific nitrosamine-derived O<sup>2</sup>-alkylthymidines in human cells

Savithri Weerasooriya, Vijay P. Jasti, Arindam Bose, Thomas E. Spratt, Ashis K. Basu, 2015, DNA Repair on p. 63-70

Human DNA polymerase ν catalyzes correct and incorrect DNA synthesis with high catalytic efficiency

A. S.Prakasha Gowda, George Lucian Moldovan, Thomas E. Spratt, 2015, Journal of Biological Chemistry on p. 16292-16303

Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress

Y. Cheng, X. Ren, A. S.P. Gowda, Y. Shan, L. Zhang, Y. S. Yuan, R. Patel, H. Wu, K. Huber-Keener, J. W. Yang, D. Liu, T. E. Spratt, J. M. Yang, 2013, Cell Death and Disease

In Vitro Epsilon RNA-Dependent Protein Priming Activity of Human Hepatitis B Virus Polymerase

Scott A. Jones, Rajeev Boregowda, Thomas E. Spratt, Jianming Hu, 2013, Journal of Virology on p. 12504

Most-Cited Papers

Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress

Y. Cheng, X. Ren, A. S.P. Gowda, Y. Shan, L. Zhang, Y. S. Yuan, R. Patel, H. Wu, K. Huber-Keener, J. W. Yang, D. Liu, T. E. Spratt, J. M. Yang, 2013, Cell Death and Disease

In vitro epsilon RNA-dependent protein priming activity of human hepatitis B virus polymerase

Scott A. Jones, Rajeev Boregowd, Thomas E. Spratt, Jianming Hu, 2012, Journal of Virology on p. 5134-5150

Development of novel naphthalimide derivatives and their evaluation as potential melanoma therapeutics

Ugir Hossain Sk, A. S. Prakasha Gowda, Melissa A. Crampsie, Jong K. Yun, Thomas E. Spratt, Shantu Amin, Arun K. Sharma, 2011, CHIM.THER. on p. 3331-3338

Tobacco-specific nitrosamine-derived O <sup>2</sup>-alkylthymidines are potent mutagenic lesions in SOS-induced escherichia coli

Vijay P. Jasti, Thomas E. Spratt, Ashis K. Basu, 2011, Chemical Research in Toxicology on p. 1833-1835

Roles of translesion synthesis DNA polymerases in the potent mutagenicity of tobacco-specific nitrosamine-derived O<sup>2</sup>-alkylthymidines in human cells

Savithri Weerasooriya, Vijay P. Jasti, Arindam Bose, Thomas E. Spratt, Ashis K. Basu, 2015, DNA Repair on p. 63-70

Low fidelity bypass of O <sup>2</sup>-(3-Pyridyl)-4-oxobutylthymine, the most persistent bulky adduct produced by the tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by Model DNA polymerases

A. S.Prakasha Gowda, Krishne Gowda, Zucai Suo, Shantu Amin, Thomas Spratt, 2012, Chemical Research in Toxicology on p. 1195-1202

Association studies of excision repair cross-complementation group 1 (ERCC1) haplotypes with lung and head and neck cancer risk in a Caucasian population

Nathan R. Jones, Thomas E. Spratt, Arthur S. Berg, Joshua E. Muscat, Philip Lazarus, Carla J. Gallagher, 2011, Cancer Epidemiology on p. 175-181

Characterization of dibenzo[ a,l pyrene- trans -11,12-diol (dibenzo[ def,p chrysene) glucuronidation by UDP-glucuronosyltransferases

Kristine C. Olson, Dongxiao Sun, Gang Chen, Arun Sharma, Shantu Amin, Ira Ropson, Thomas Spratt, Philip Lazarus, 2011, Chemical Research in Toxicology on p. 1549-1559

DNA Polymerases η and ζ Combine to Bypass O<sup>2</sup>-[4-(3-Pyridyl)-4-oxobutyl]thymine, a DNA Adduct Formed from Tobacco Carcinogens

A. S. Prakasha Gowda, Thomas E. Spratt, 2016, Chemical Research in Toxicology on p. 303-316

Human DNA polymerase ν catalyzes correct and incorrect DNA synthesis with high catalytic efficiency

A. S.Prakasha Gowda, George Lucian Moldovan, Thomas E. Spratt, 2015, Journal of Biological Chemistry on p. 16292-16303