Thomas Spratt
Associate Professor or Biochemistry
-
Hershey Med Ctr
Hershey, - tes13@psu.edu
Huck Affiliations
Publication Tags
Dna Directed Dna Polymerase Tobacco Dna Dna Polymerase Beta Carcinogens Deoxyguanosine Triphosphate Adduct Dna Adducts Thymidine 5' Triphosphate Substrates Escherichia Coli 4 (N Methyl N Nitrosamino) 1 (3 Pyridyl) 1 Butanone Nitrosamines Human Dna Polymerase N Nucleotides Deoxyguanosine Thymine Base Pairing Cells 2' Deoxycytidine 5' Triphosphate Honokiol Derivatives N' Nitrosonornicotine Rad30 Protein Benzo(A)PyreneMost Recent Publications
Unique DNA Polymerase kappa Interactome Suggests Novel Cellular Functions
Shilpi Paul, Paolo Cifani, Darryl Pappin, Thomas Spratt, 2022, FASEB Journal
Active Site Interactions Impact Phosphoryl Transfer during Replication of Damaged and Undamaged DNA by Escherichia coli DNA Polymerase i
A. S. Prakasha Gowda, Thomas E. Spratt, 2017, Chemical Research in Toxicology on p. 2033-2043
Mutagenic Replication of N<sup>2</sup>-Deoxyguanosine Benzo[a]pyrene Adducts by Escherichia coli DNA Polymerase i and Sulfolobus solfataricus DNA Polymerase IV
A. S.Prakasha Gowda, Jacek Krzeminski, Shantu Amin, Zucai Suo, Thomas E. Spratt, 2017, Chemical Research in Toxicology on p. 1168-1176
N<sup>2</sup>-Substituted 2′-Deoxyguanosine Triphosphate Derivatives as Selective Substrates for Human DNA Polymerase κ
A. S.Prakasha Gowda, Marietta Lee, Thomas E. Spratt, 2017, Angewandte Chemie - International Edition on p. 2628-2631
Honokiol Inhibits DNA Polymerases β and λ and Increases Bleomycin Sensitivity of Human Cancer Cells
A. S.Prakasha Gowda, Zucai Suo, Thomas E. Spratt, 2017, Chemical Research in Toxicology on p. 715-725
DNA Polymerase ν Rapidly Bypasses O<sup>6</sup>-Methyl-dG but Not O<sup>6</sup>-[4-(3-Pyridyl)-4-oxobutyl-dG and O<sup>2</sup>-Alkyl-dTs
A. S.Prakasha Gowda, Thomas E. Spratt, 2016, Chemical Research in Toxicology on p. 1894-1900
DNA Polymerases η and ζ Combine to Bypass O<sup>2</sup>-[4-(3-Pyridyl)-4-oxobutyl]thymine, a DNA Adduct Formed from Tobacco Carcinogens
A. S. Prakasha Gowda, Thomas E. Spratt, 2016, Chemical Research in Toxicology on p. 303-316
Roles of translesion synthesis DNA polymerases in the potent mutagenicity of tobacco-specific nitrosamine-derived O<sup>2</sup>-alkylthymidines in human cells
Savithri Weerasooriya, Vijay P. Jasti, Arindam Bose, Thomas E. Spratt, Ashis K. Basu, 2015, DNA Repair on p. 63-70
Human DNA polymerase ν catalyzes correct and incorrect DNA synthesis with high catalytic efficiency
A. S.Prakasha Gowda, George Lucian Moldovan, Thomas E. Spratt, 2015, Journal of Biological Chemistry on p. 16292-16303
Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress
Y. Cheng, X. Ren, A. S.P. Gowda, Y. Shan, L. Zhang, Y. S. Yuan, R. Patel, H. Wu, K. Huber-Keener, J. W. Yang, D. Liu, T. E. Spratt, J. M. Yang, 2013, Cell Death and Disease
Most-Cited Papers
Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress
Y. Cheng, X. Ren, A. S.P. Gowda, Y. Shan, L. Zhang, Y. S. Yuan, R. Patel, H. Wu, K. Huber-Keener, J. W. Yang, D. Liu, T. E. Spratt, J. M. Yang, 2013, Cell Death and Disease
In vitro epsilon RNA-dependent protein priming activity of human hepatitis B virus polymerase
Scott A. Jones, Rajeev Boregowd, Thomas E. Spratt, Jianming Hu, 2012, Journal of Virology on p. 5134-5150
Roles of translesion synthesis DNA polymerases in the potent mutagenicity of tobacco-specific nitrosamine-derived O<sup>2</sup>-alkylthymidines in human cells
Savithri Weerasooriya, Vijay P. Jasti, Arindam Bose, Thomas E. Spratt, Ashis K. Basu, 2015, DNA Repair on p. 63-70
Low fidelity bypass of O <sup>2</sup>-(3-Pyridyl)-4-oxobutylthymine, the most persistent bulky adduct produced by the tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by Model DNA polymerases
A. S.Prakasha Gowda, Krishne Gowda, Zucai Suo, Shantu Amin, Thomas Spratt, 2012, Chemical Research in Toxicology on p. 1195-1202
Honokiol Inhibits DNA Polymerases β and λ and Increases Bleomycin Sensitivity of Human Cancer Cells
A. S.Prakasha Gowda, Zucai Suo, Thomas E. Spratt, 2017, Chemical Research in Toxicology on p. 715-725
DNA Polymerases η and ζ Combine to Bypass O<sup>2</sup>-[4-(3-Pyridyl)-4-oxobutyl]thymine, a DNA Adduct Formed from Tobacco Carcinogens
A. S. Prakasha Gowda, Thomas E. Spratt, 2016, Chemical Research in Toxicology on p. 303-316
N<sup>2</sup>-Substituted 2′-Deoxyguanosine Triphosphate Derivatives as Selective Substrates for Human DNA Polymerase κ
A. S.Prakasha Gowda, Marietta Lee, Thomas E. Spratt, 2017, Angewandte Chemie - International Edition on p. 2628-2631
Human DNA polymerase ν catalyzes correct and incorrect DNA synthesis with high catalytic efficiency
A. S.Prakasha Gowda, George Lucian Moldovan, Thomas E. Spratt, 2015, Journal of Biological Chemistry on p. 16292-16303
DNA Polymerase ν Rapidly Bypasses O<sup>6</sup>-Methyl-dG but Not O<sup>6</sup>-[4-(3-Pyridyl)-4-oxobutyl-dG and O<sup>2</sup>-Alkyl-dTs
A. S.Prakasha Gowda, Thomas E. Spratt, 2016, Chemical Research in Toxicology on p. 1894-1900
Mutagenic Replication of N<sup>2</sup>-Deoxyguanosine Benzo[a]pyrene Adducts by Escherichia coli DNA Polymerase i and Sulfolobus solfataricus DNA Polymerase IV
A. S.Prakasha Gowda, Jacek Krzeminski, Shantu Amin, Zucai Suo, Thomas E. Spratt, 2017, Chemical Research in Toxicology on p. 1168-1176