Thomas Spratt
Associate Professor or Biochemistry
-
Hershey Med Ctr
Hershey, - tes13@psu.edu
Huck Affiliations
Publication Tags
Dna Directed Dna Polymerase Tobacco Dna Nitrosamines Carcinogens Dna Adducts Escherichia Coli Thymidine 5' Triphosphate 4 (N Methyl N Nitrosamino) 1 (3 Pyridyl) 1 Butanone Deoxyguanosine Triphosphate Human Dna Polymerase N Thymine Dna Polymerase Beta Nucleotides Cells Dna Polymerase Zeta N' Nitrosonornicotine Rad30 Protein Thymidine Substrates O2 (4 (3 Pyridyl) 4 Oxobut 1 Yl)Thymidine Base Pairing Neoplasms 2' Deoxycytidine 5' Triphosphate DerivativesMost Recent Papers
Active Site Interactions Impact Phosphoryl Transfer during Replication of Damaged and Undamaged DNA by Escherichia coli DNA Polymerase i
A. S. Prakasha Gowda, Thomas E. Spratt, 2017, Chemical Research in Toxicology on p. 2033-2043
Mutagenic Replication of N<sup>2</sup>-Deoxyguanosine Benzo[a]pyrene Adducts by Escherichia coli DNA Polymerase i and Sulfolobus solfataricus DNA Polymerase IV
A. S.Prakasha Gowda, Jacek Krzeminski, Shantu Amin, Zucai Suo, Thomas E. Spratt, 2017, Chemical Research in Toxicology on p. 1168-1176
N<sup>2</sup>-Substituted 2′-Deoxyguanosine Triphosphate Derivatives as Selective Substrates for Human DNA Polymerase κ
A. S.Prakasha Gowda, Marietta Lee, Thomas E. Spratt, 2017, Angewandte Chemie - International Edition on p. 2628-2631
Honokiol Inhibits DNA Polymerases β and λ and Increases Bleomycin Sensitivity of Human Cancer Cells
A. S.Prakasha Gowda, Zucai Suo, Thomas E. Spratt, 2017, Chemical Research in Toxicology on p. 715-725
DNA Polymerase ν Rapidly Bypasses O<sup>6</sup>-Methyl-dG but Not O<sup>6</sup>-[4-(3-Pyridyl)-4-oxobutyl-dG and O<sup>2</sup>-Alkyl-dTs
A. S.Prakasha Gowda, Thomas E. Spratt, 2016, Chemical Research in Toxicology on p. 1894-1900
DNA Polymerases η and ζ Combine to Bypass O<sup>2</sup>-[4-(3-Pyridyl)-4-oxobutyl]thymine, a DNA Adduct Formed from Tobacco Carcinogens
A. S. Prakasha Gowda, Thomas E. Spratt, 2016, Chemical Research in Toxicology on p. 303-316
Roles of translesion synthesis DNA polymerases in the potent mutagenicity of tobacco-specific nitrosamine-derived O<sup>2</sup>-alkylthymidines in human cells
Savithri Weerasooriya, Vijay P. Jasti, Arindam Bose, Thomas E. Spratt, Ashis K. Basu, 2015, DNA Repair on p. 63-70
Human DNA polymerase ν catalyzes correct and incorrect DNA synthesis with high catalytic efficiency
A. S.Prakasha Gowda, George Lucian Moldovan, Thomas E. Spratt, 2015, Journal of Biological Chemistry on p. 16292-16303
Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress
Y. Cheng, X. Ren, A. S.P. Gowda, Y. Shan, L. Zhang, Y. S. Yuan, R. Patel, H. Wu, K. Huber-Keener, J. W. Yang, D. Liu, T. E. Spratt, J. M. Yang, 2013, Cell Death and Disease
In Vitro Epsilon RNA-Dependent Protein Priming Activity of Human Hepatitis B Virus Polymerase
Scott A. Jones, Rajeev Boregowda, Thomas E. Spratt, Jianming Hu, 2013, Journal of Virology on p. 12504
Most-Cited Papers
Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress
Y. Cheng, X. Ren, A. S.P. Gowda, Y. Shan, L. Zhang, Y. S. Yuan, R. Patel, H. Wu, K. Huber-Keener, J. W. Yang, D. Liu, T. E. Spratt, J. M. Yang, 2013, Cell Death and Disease
In vitro epsilon RNA-dependent protein priming activity of human hepatitis B virus polymerase
Scott A. Jones, Rajeev Boregowd, Thomas E. Spratt, Jianming Hu, 2012, Journal of Virology on p. 5134-5150
Development of novel naphthalimide derivatives and their evaluation as potential melanoma therapeutics
Ugir Hossain Sk, A. S. Prakasha Gowda, Melissa A. Crampsie, Jong K. Yun, Thomas E. Spratt, Shantu Amin, Arun K. Sharma, 2011, European Journal of Medicinal Chemistry on p. 3331-3338
Tobacco-specific nitrosamine-derived O <sup>2</sup>-alkylthymidines are potent mutagenic lesions in SOS-induced escherichia coli
Vijay P. Jasti, Thomas E. Spratt, Ashis K. Basu, 2011, Chemical Research in Toxicology on p. 1833-1835
Roles of translesion synthesis DNA polymerases in the potent mutagenicity of tobacco-specific nitrosamine-derived O<sup>2</sup>-alkylthymidines in human cells
Savithri Weerasooriya, Vijay P. Jasti, Arindam Bose, Thomas E. Spratt, Ashis K. Basu, 2015, DNA Repair on p. 63-70
Low fidelity bypass of O <sup>2</sup>-(3-Pyridyl)-4-oxobutylthymine, the most persistent bulky adduct produced by the tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by Model DNA polymerases
A. S.Prakasha Gowda, Krishne Gowda, Zucai Suo, Shantu Amin, Thomas Spratt, 2012, Chemical Research in Toxicology on p. 1195-1202
Association studies of excision repair cross-complementation group 1 (ERCC1) haplotypes with lung and head and neck cancer risk in a Caucasian population
Nathan R. Jones, Thomas E. Spratt, Arthur S. Berg, Joshua E. Muscat, Philip Lazarus, Carla J. Gallagher, 2011, Cancer Epidemiology on p. 175-181
Characterization of dibenzo[ a,l pyrene- trans -11,12-diol (dibenzo[ def,p chrysene) glucuronidation by UDP-glucuronosyltransferases
Kristine C. Olson, Dongxiao Sun, Gang Chen, Arun Sharma, Shantu Amin, Ira Ropson, Thomas Spratt, Philip Lazarus, 2011, Chemical Research in Toxicology on p. 1549-1559
DNA Polymerases η and ζ Combine to Bypass O<sup>2</sup>-[4-(3-Pyridyl)-4-oxobutyl]thymine, a DNA Adduct Formed from Tobacco Carcinogens
A. S. Prakasha Gowda, Thomas E. Spratt, 2016, Chemical Research in Toxicology on p. 303-316
Human DNA polymerase ν catalyzes correct and incorrect DNA synthesis with high catalytic efficiency
A. S.Prakasha Gowda, George Lucian Moldovan, Thomas E. Spratt, 2015, Journal of Biological Chemistry on p. 16292-16303