62 People Results for the Tag: Ligands

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Istvan Albert

Associate Professor of Bioinformatics
Bioinformatics, large scale biological data analysis, microarrays and sequence analysis. Scientific programming, algorithm development. Database-driven web development.

Center for Infectious Disease Dynamics

Benjamin Allen

Assistant Research Professor
Computational approaches to protein engineering; Using protein structure to guide bioinformatics for projects including identification of malaria vaccine targets

Margherita Cantorna

Emphasis Area Representative, Immunology and Infectious Disease; Director of the Center for Molecular Immunology and Infectious Disease; Distinguished Professor of Molecular Immunology
Understanding the working of the immune system. Utilizing animal models of several human diseases including enteric infections and inflammatory bowel disease to determine the cellular targets and molecular signals by which dietary components regulate immunity.

Center for Infectious Disease Dynamics

Adam Glick

Associate Chair, Molecular Cellular and Integrative Biosciences; Emphasis Area Representative, Cancer Biology; Professor of Molecular Toxicology and Carcinogenesis;
The role of Transforming Growth Factor-beta in cutaneous inflammation and cancer development, and how the immune system responds to epithelial cells with activated oncogenes such as Ras. Signaling pathways that regulate senescence of premalignant epithelial cells and how cells escape from oncogene-induced senescence.

Center for Infectious Disease Dynamics

Carsten Krebs

Professor of Chemistry, Professor of Biochemistry and Molecular Biology
Bioinorganic Chemistry - spectroscopic and kinetic studies on the mechanisms of iron-containing enzymes

Aimin Liu

Associate Professor of Biology
Biogenesis and function of cilia in mammalian embryonic development.

Richard Mailman

Professor and College of Medicine Distinguished Senior Scholar

Robert Paulson

Professor of Veterinary and Biomedical Sciences
The Paulson lab studies the mechanisms that regulate tissue regeneration with a focus on understanding the response to anemic and hypoxic stress

Jeffrey Peters

Distinguished Professor of Molecular Toxicology and Carcinogenesis
Roles of peroxisome proliferator-activated receptors (PPARs) in the regulation of homeostasis, toxicology, and carcinogenesis.

Kathleen Postle

Professor of Biochemistry and Molecular Biology
Signal transduction and iron transport in bacteria

Jason Rasgon

Professor of Entomology and Disease Epidemiology
Integrating population biology, ecology, molecular tools and theory to address fundamental and applied questions related to vector arthropods and the pathogens they transmit.

Center for Infectious Disease Dynamics

Philip Smith

Director, Metabolomics Core Facility; Senior Research Associate, Proteomics and Mass Spectrometry Core Facility (University Park)

Mary Kennett

Professor, Veterinary & Biomedical Sciences; Director, Animal Resource Program
The pathogenesis of infectious disease: examining bacterial virulence and associated pathology in relation to host immune responses.

Center for Infectious Disease Dynamics

Arthur Lesk

Professor of Biochemistry and Molecular Biology

Cheng Dong

Advisor for the Center for Mathematics of Living and Mimetic Matter

Fang (Rose) Zhu

Assistant Professor of Entomology
Understanding the mechanisms and evolution of insects’ adaptation to chemical stresses in their environment.

Pamela Giblin

Professor of Immunology
The role of receptor tyrosine kinases in normal physiology and disease progression; the downstream signals that mediate these responses in vivo and in vitro.

Scott Showalter

Professor of Chemistry; Professor of Biochemistry and Molecular Biology
Biophysical Chemistry applied to solution NMR spectroscopy of partially disordered proteins. NMR studies of protein dynamics coupled with computational and theoretical studies of the coupling between nuclear spin relaxation and molecular motion.

Sujit Pujhari

Assistant Research Professor

Troy Ott

Associate Director for Graduate Education, Huck Institutes of the Life Sciences; Professor of Reproductive Physiology
Reproductive immunology and the physiology of early pregnancy.

Claire Thomas

Associate Professor of Biology and of Biochemistry and Molecular Biology
Roles of the cytoskeleton at the cell membrane in epithelial cells, including issues of cell polarity and adhesion, cell signaling, and morphogenesis.

Gary Perdew

Director of the Center for Molecular Toxicology and Carcinogenesis; John T. and Paige S. Smith Professor in Agricultural Sciences
Mechanisms of receptor-mediated carcinogenesis.

Jack Vanden Heuvel

Director of the Center for Excellence in Nutrigenomics; Professor of Molecular Toxicology
Mechanisms of action of hypolipidemic drugs and peroxisome proliferators; steroid hormone receptor-mediated signal transduction; signal transduction by lipids and fatty acids; receptor-mediated carcinogenesis.

J. Martin Bollinger

Professor of Chemistry; Professor of Biochemistry and Molecular Biology
Mechanisms of metalloenzymes and metallofactor assembly

John Golbeck

Professor of Biochemistry and Biophysics
Light reactions in photosynthesis. Structure and function of photosystem I and the heliobacterial reaction center. Regulation and bioassembly of iron-sulfur clusters in cyanobacteria and plants. Plant and bacterial metalloproteins. Generation using Photosystem I, hydrogenase, and molecular wire technology.

Neil Christensen

Professor of Pathology and Microbiology and Immunology

Regina Vasilatos-Younken

Dean of the Graduate School; Professor of Poultry Science, Endocrine Physiology, and Nutrition
Role of endocrine and metabolic factors in the regulation of muscle and adipose tissue growth.

Diane Thiboutot

Professor of Medicine and Dermatology

Peter Butler

Professor of Bioengineering
Fundamental molecular mechanisms by which vascular endothelial cells sense the forces from flowing blood and transduce this mechanical information into adjustments of cell and tissue biology.

Shantu Amin

Professor of Pharmacology

Kumble Sandeep Prabhu

Professor of Immunology and Molecular Toxicology
Molecular mechanisms by which bioactives such as selenium, omega-3 fatty acids, and other products of natural origin alter the host response and immune function in inflammation and cancer

Rosalyn Irby

Associate Professor of Cancer Research

Jin-Ming Yang

Professor of Pharmacology

Kevin Harvatine

Associate Professor of Nutritional Physiology
Investigation of dietary factors that modify ruminal fatty acid biohydrogenation, regulation of synthesis of milk components, and basic regulation of lipid synthesis with the continual goal of developing feeding strategies to improve the efficiency and performance of dairy cows

Sinisa Dovat

Associate Professor of Pediatric Hematology and Oncology
Investigate the role of lymphoid master regulator, IKZF1/Ikaros, in the development of acute lymphoblastic leukemia (ALL); other transcriptional factors in leukemia; CK2 activity; chromatin remodeling; super-enhancers.

Justin Brown

Associate Professor of Bioengineering
Understanding the fundamental mechanisms by which biomaterial interfaces alter the proliferation, migration and differentiation of mesenchymal stem cells, and application of these principles in the intelligent design of biomaterial scaffolds that facilitate generation or regeneration of musculoskeletal tissues

Yong Wang

Professor of Biomedical Engineering
Applying nature and biology as design guidelines to the creation of biomimetic and bioinspired materials at both the nanoscale and macroscale level for drug delivery, clinical diagnosis, and regenerative medicine.

Xin Zhang

Assistant Professor of Chemistry; Assistant Professor of Biochemistry and Molecular Biology; Paul Berg Early Career Professorship in the Eberly College of Science
Developing chemical tools to monitor cellular stresses that influence protein folding in real time. Deciphering how the energy landscapes associated with proper protein folding and function are regulated by the cellular folding environment. Examining how this regulation leads to significant biological consequences.

Mary Kathryn Schmitz

Professor of Epidemiology

Scott Medina

Assistant Professor of Biomedical Engineering
Design of bio-inspired functional materials that serve as new tools in precision medicine. Understanding how peptides and proteins assemble at natural and non-natural interfaces to form organized structures with unique biochemical functions. The design of nano- and micro-scale biomaterials to develop new biosensing and therapeutic strategies to treat infectious disease, inflammation and cancer.

Andrew Patterson

Professor and Huck Chair of Molecular Toxicology
The Patterson lab is focused on understanding the host-metabolite-microbiome axis

Nikolay Dokholyan

G. Thomas Passananti Professor
We are a translational systems research group in the Pharmacology at the Penn State College of Medicine. Our laboratory focuses on understanding etiologies of human diseases, such as cystic fibrosis (CF), amyotrophic lateral sclerosis (ALS), and pain conditions, such as hyperalgesia.

Elizabeth Proctor

Assistant Professor of Neurosurgery, Pharmacology, and Biomedical Engineering
Systems biology of complex disease. Integration of heterogeneous data types across length scales.

Frank Dorman

Associate Professor Biochemistry and Molecular Biology

Squire Booker

Evan Pugh Professor of Chemistry; Professor of Biochemistry and Molecular Biology
Elucidating the chemical mechanisms by which enzymes containing iron-sulfur clusters catalyze chemical reactions. Most ongoing projects deal with members of the Radical S-adenosylmethionine Superfamily, a diverse group of enzymes that employ radical chemistry to catalyze transformations involved in post-transcriptional and post-translational modifications, cofactor biosynthesis, secondary metabolite biosynthesis, and enzyme activation.

Joseph Cotruvo

Assistant Professor of Chemistry
Biochemistry and chemical biology to uncover and understand new metal and redox biology. We are particularly interested in applications to infectious disease, bioenergy, and cancer biology.

Sulin Zhang

Professor of Engineering Science and Mechanics

Thomas Ma

Professor and Chair of Medicine

Emily Weinert

Associate Professor of Biochemistry and Molecular Biology
The mechanisms by which bacteria sense and respond to the environment, as well as how these signaling proteins/pathways affect competition, host colonization, and pathogenesis.