32 People Results for the Tag: Ligand
Adam Glick
Emphasis Area Representative, Cancer Biology; Professor of Molecular Toxicology and Carcinogenesis;
The role of Transforming Growth Factor-beta in cutaneous inflammation and cancer development, and how the immune system responds to epithelial cells with activated oncogenes such as Ras. Signaling pathways that regulate senescence of premalignant epithelial cells and how cells escape from oncogene-induced senescence.
Center for Infectious Disease Dynamics
Carsten Krebs
Professor of Chemistry, Professor of Biochemistry and Molecular Biology
Bioinorganic Chemistry - spectroscopic and kinetic studies on the mechanisms of iron-containing enzymes
Richard Mailman
Professor and College of Medicine Distinguished Senior Scholar
Robert Paulson
Professor of Veterinary and Biomedical Sciences
The Paulson lab studies the mechanisms that regulate tissue regeneration with a focus on understanding the response to anemic and hypoxic stress
Jeffrey Peters
Distinguished Professor of Molecular Toxicology and Carcinogenesis
Roles of peroxisome proliferator-activated receptors (PPARs) in the regulation of homeostasis, toxicology, and carcinogenesis.
Cheng Dong
Advisor for the Center for Mathematics of Living and Mimetic Matter
Pamela Giblin
Professor of Immunology
The role of receptor tyrosine kinases in normal physiology and disease progression; the downstream signals that mediate these responses in vivo and in vitro.
Elsa Hansen
Assistant Research Professor - Read Lab
Evolution, transmission and management of drug-resistance. Improving treatment of infectious disease and cancer using mathematical models and optimal control theory.
Center for Infectious Disease Dynamics
B. Tracy Nixon
Professor of Biochemistry and Molecular Biology
Structural and functional basis of cellulose synthesis. Using Physcomitrella patens and other organisms as model systems, we are learning how plants make cellulose for building new cell wall. The studies use methods of molecular biology and cryoEM to characterize the enzyme as a monomer, and when it assembles into its larger 'Cellulose Synthase Complex '(CSC for short). The aim is to understand cellulose synthesis to explain fundamentals of cell wall biology in plants, and to enable manipulation of its synthesis for applications in fields of bioenergy and materials.
Claire Thomas
Associate Professor of Biology and of Biochemistry and Molecular Biology
Roles of the cytoskeleton at the cell membrane in epithelial cells, including issues of cell polarity and adhesion, cell signaling, and morphogenesis.
Gary Perdew
Director of the Center for Molecular Toxicology and Carcinogenesis; H. Thomas and Dorothy Willits Hallowell Chair in Agricultural Sciences
Mechanisms of receptor-mediated carcinogenesis.
J. Martin Bollinger
Professor of Chemistry; Professor of Biochemistry and Molecular Biology
Mechanisms of metalloenzymes and metallofactor assembly
Donald Bryant
Ernest C. Pollard Professor of Biotechnology; Professor of Biochemistry and Molecular Biology
Photosynthesis, structure-function relationships of proteins, gene regulation, and microbial physiology. Cyanobacteria and green sulfur bacteria. Genomics of photosynthetic bacteria.
John Golbeck
Professor of Biochemistry and Biophysics
Light reactions in photosynthesis. Structure and function of photosystem I and the heliobacterial reaction center. Regulation and bioassembly of iron-sulfur clusters in cyanobacteria and plants. Plant and bacterial metalloproteins. Generation using Photosystem I, hydrogenase, and molecular wire technology.
Craig Meyers
Distinguished Professor of Microbiology and Immunology
The differentiation-dependent life cycle of human papillomavirus (HPV) and HPV-associated oncogenesis.
Kumble Sandeep Prabhu
Professor of Immunology and Molecular Toxicology
Molecular mechanisms by which bioactives such as selenium, omega-3 fatty acids, and other products of natural origin alter the host response and immune function in inflammation and cancer
Tatiana Laremore
Director, Proteomics and Mass Spectrometry Core Facility; Associate Research Professor
Neela Yennawar
Director, X-Ray Crystallography and Automated Biological Calorimetry Core Facilities; Research Professor
Biological calorimetry, protein characterization, molecular modeling, X-ray crystallography, and small-angle X-ray scattering.
Andrew Patterson
Professor and Huck Chair of Molecular Toxicology; Faculty Oversight, Metabolomics Core Facility
The Patterson lab is focused on understanding the host-metabolite-microbiome axis
Squire Booker
Evan Pugh Professor of Chemistry; Professor of Biochemistry and Molecular Biology
Elucidating the chemical mechanisms by which enzymes containing iron-sulfur clusters catalyze chemical reactions. Most ongoing projects deal with members of the Radical S-adenosylmethionine Superfamily, a diverse group of enzymes that employ radical chemistry to catalyze transformations involved in post-transcriptional and post-translational modifications, cofactor biosynthesis, secondary metabolite biosynthesis, and enzyme activation.
Joseph Cotruvo
Associate Professor of Chemistry
Biochemistry and chemical biology to uncover and understand new metal and redox biology. We are particularly interested in applications to infectious disease, bioenergy, and cancer biology.
Jean-Paul Armache
Assistant Professor of of Biochemistry and Molecular Biology
The mechanisms and functions of ATP-dependent chromatin remodeling complexes and their place in gene regulation.
Center for Infectious Disease Dynamics
Denise Okafor
Assistant Professor of Biochemistry and Molecular Biology
Structural mechanisms of signaling and regulation in protein complexes.
Amie Boal
Professor of Chemistry and of Biochemistry and Molecular Biology
The structural differences between members of large metalloenzyme superfamilies that share common features but promote different reactions or use distinct cofactors.
Jeremiah Keyes
Assistant Professor of Biochemistry and Molecular Biology and of Biology, Penn State Behrend
The complex signaling networks that control cell responses to stimuli.