169 People Results for the Tag: Dna
Michael Axtell
Distinguished Professor of Biology
Discovery and characterization of plant microRNAs and siRNAs. Functions of microRNAs and siRNAs in the evolution of plant development. Genomics and bioinformatics of microRNAs, siRNAs, and their targets
John Carlson
Professor of Molecular Genetics; Director, Schatz Center for Tree Molecular Genetics
Genome mapping, including genetic linkage mapping, molecular cytogenetics; studies of genetic diversity in forests.
Isabella Cattadori
Professor of Biology
Immuno-epidemiology of co-infection, how host immunity modulates parasite interactions and transmission and how host molecular processes explain the dynamics of infection at the population level.
Center for Infectious Disease Dynamics
Adam Glick
Associate Chair, Molecular Cellular and Integrative Biosciences; Emphasis Area Representative, Cancer Biology; Professor of Molecular Toxicology and Carcinogenesis;
The role of Transforming Growth Factor-beta in cutaneous inflammation and cancer development, and how the immune system responds to epithelial cells with activated oncogenes such as Ras. Signaling pathways that regulate senescence of premalignant epithelial cells and how cells escape from oncogene-induced senescence.
Center for Infectious Disease Dynamics
Susan Hafenstein
Director of the Center for Structural Biology; Huck Chair of Structural Virology; Professor of Biochemistry and Molecular Biology
Using a structural approach to learn more about viral infectivity, tropism, evolution and pathogenicity. Developing approaches to visualize critical events that cause a break from the regular symmetry of the virus, including packaging of the genome, receptor usage, antibody interactions and uncoating of the viral genome during the final stages of infection.
Center for Infectious Disease Dynamics
Mark Hedglin
Assistant Professor of Chemistry; Assistant Professor of Biochemistry and Molecular Biology
Deciphering how efficient and faithful replication of the human genome is achieved within the highly-complex, dynamic, and reactive environment of the nucleus. Identifying pathways for genomic instability in humans, identifying novel oncogenic drug targets, developing better chemotherapeutic treatments for human cancers caused by genomic instability.
Heather Hines
Associate Professor of Biology and Entomology
Applies genomic, transcriptomic, phylogenomic, and bioinformatic approaches to study the evolution and genetics of diverse traits in bees and wasps. This includes study of mimetic color diversification, plant gall induction, novel morphologies, speciation, and social evolution.
Andrey Krasilnikov
Associate Professor of Biochemistry and Molecular Biology
Structural biology of RNA and RNA-protein complexes
Tae-Hee Lee
Professor of Chemistry
Single-molecule biophysics of the nucleosome and chromatin
Manuel Llinas
Distinguished Professor of Biochemistry and Molecular Biology
Understanding the molecular mechanisms of gene regulation and metabolism in the malaria parasite Plasmodium falciparum using functional genomics and metabolomics.
Center for Infectious Disease Dynamics
Sally Mackenzie
Director of the Plant Institute; Huck Chair of Functional Genomics; Professor of Biology and of Plant Science
Organelle biology and cellular specializations. Plant epigenetics, memory and phenotypic plasticity. Crop epigenetic breeding.
Elizabeth McGraw
Professor and Huck Scholar in Entomology
The genetics of vector, pathogen and symbiont interactions.
Center for Infectious Disease Dynamics
George Perry
Chair, Intercollege Graduate Degree Program in Bioinformatics and Genomics; Associate Professor of Anthropology and Biology
Anthropological genomics, paleogenomics, human body size evolution, parasite evolution, and evolutionary medicine.
Center for Infectious Disease Dynamics
Jason Rasgon
Professor of Entomology and Disease Epidemiology
Integrating population biology, ecology, molecular tools and theory to address fundamental and applied questions related to vector arthropods and the pathogens they transmit.
Center for Infectious Disease Dynamics
Cooduvalli Shashikant
Former Chair, Intercollege Graduate Degree Program in Bioinformatics and Genomics
Developmental and evolutionary aspects of regulation of patterning genes.
Song Tan
Director of the Center for Eukaryotic Gene Regulation; Professor of Biochemistry and Molecular Biology
Structural biology of eukaryotic gene regulation.
Yinong Yang
Professor, Department of Plant Pathology and Environmental Microbiology
Signal perception and transduction in rice-pathogen interactions. Molecular and genomic strategies for increasing disease resistance and drought tolerance in cereal crops.
Anne Vardo-Zalik
Assistant Professor of Biology
The ecology and population genetics of malaria parasites and their vectors
Center for Infectious Disease Dynamics
Edward Levri
Associate Professor of Biology
Research interests lie in the evolutionary ecology of parasitism and disease, invasion ecology, and predator-prey interactions.
Center for Infectious Disease Dynamics
Judd Michael
Nationwide Insurance Professor of Safety & Health; Professor of Agricultural and Biological Engineering
James Marden
Associate Director of Operations, Huck Institutes of the Life Sciences; Professor of Biology
How physiological variation within species affects their ecology and evolution. Primarily with insects, but recently also with plants, and a particular interest in allelic variation in the pathogen resistance genes of tropical trees.
Center for Infectious Disease Dynamics
Moriah Szpara
Associate Professor of Biochemistry & Molecular Biology and Biology
How genetic variation influences the outcomes of viral infection, particularly for neurotropic viruses such as herpes simplex virus 1 (HSV-1) and HSV-2, using high-throughput sequencing, comparative genomics, neuronal cultures, and genetic manipulation of both host and pathogen.
Center for Infectious Disease Dynamics
Murali Haran
Associate Professor of Statistics
Statistical computing (Markov chain Monte Carlo algorithms); spatial models (Gaussian random field models); methods for complex computer models; interdisciplinary collaborations in environmental sciences, climate science, disease modeling, ecology
Center for Infectious Disease Dynamics
Peter Hudson
Former Director, Huck Institutes of the Life Sciences; Willaman Professor of Biology
Population dynamics of infectious diseases in wildlife and the dynamics of parasite community structure.
Center for Infectious Disease Dynamics
Scott Lindner
Associate Professor of Biochemistry & Molecular Biology, Co-Director, Center for Malaria Research
Our laboratory couples molecular parasitology and structural biology to study the malaria parasite (Plasmodium spp.).
Center for Infectious Disease Dynamics
Cheng Dong
Advisor for the Center for Mathematics of Living and Mimetic Matter
Dajiang Liu
Co-Chair, Intercollege Graduate Degree Program in Bioinformatics and Genomics; Professor of Public Health Sciences and Biochemistry and Molecular Biology
Developing novel methods to analyze very large scale datasets in order to identify genes that are responsible for disease, understand the disease mechanism, and gain clinical insights.
David Gilmour
Professor of Molecular and Cell Biology
Transcriptional regulation of the hsp70 heat shock gene in Drosophila.
Francesca Chiaromonte
Director of the Genome Sciences Institute; Huck Chair in Statistics for the Life Sciences; Professor of Statistics
Developing methods for the analysis of large, high-dimensional and complex data.
Francisco Diaz
Associate Professor of Reproductive Biology
Ovarian physiology. Role of SMAD-mediated signaling in follicular and female germ cell (oocyte) development.
Harland Patch
Assistant Research Professor; Research Associate of Entomology
Howard Salis
Associate Professor of Chemical Engineering; Associate Professor of Agricultural and Biological Engineering
Engineering microorganisms for applications in synthetic biology and metabolic engineering.
John Regan
Professor of Civil and Environmental Engineering
Biological treatment processes, molecular microbial ecology, bioenergy production.
Joseph Reese
Professor of Biochemistry and Molecular Biology
Gene regulation in cell cycle and DNA damage control; regulation of DNA damage-induced transcription.
Kateryna Makova
Director of the Center for Medical Genomics; Professor of Biology
Molecular evolution, population genetics, evolutionary genomics, bioinformatics, and human genetics.
Lu Bai
Associate Professor of Biochemistry and Molecular Biology; Associate Professor of Physics
Single cell / single molecule study of chromatin and gene regulation.
Philip Bevilacqua
Co-Director, Center for RNA Molecular Biology; Distinguished Professor of Chemistry and of Biochemistry and Molecular Biology
RNA folding in vivo and genome-wide; RNA regulation of gene expression; Ribozyme Mechanism; roles RNA may have played in the emergence of life on early earth
Ross Hardison
Associate Director of the Genome Sciences Institute; T. Ming Chu Professor of Biochemistry and Molecular Biology
Regulation of gene expression during development.
Shaun Mahony
Associate Professor of Biochemistry & Molecular Biology
We apply neural networks and other machine learning approaches to understand how transcription factors control cellular identity
Stephen Schaeffer
Professor of Biology
Population Genetics and Genomics of Chromosomal Rearrangements in Drosophila
Tracy Langkilde
Professor of Biology; Dean of the Eberly College of Science
The interface of ecology and evolution to understand how an organism's traits are matched to its environment and responds to novel selective pressures imposed by global environmental change, and the consequences of this adaptation.
Center for Infectious Disease Dynamics
William Hancock
Professor of Bioengineering
The detailed workings of motor proteins and their role in intracellular transport and cell motility.
Robab Katani
Assistant Research Professor of Global Health
Global health security, infectious diseases, and host-pathogen dynamics, as well as expertise in the enhancement of capabilities in the Low- and Middle-Income Countries, including Tanzania and India.
Center for Infectious Disease Dynamics
James Connor
Distinguished Professor and Vice Chair of Neurosurgery
Iron transport and toxicity in neurodegenerative diseases/oxidative cell injury.
Teh-hui Kao
Chair, Intercollege Graduate Degree Program in Plant Biology; Distinguished Professor of Biochemistry and Molecular Biology
Molecular, biochemical, and structural bases of the S-RNase-based self-incompatibility system in flowering plants. F-box protein-mediated ubiquitination and degradation of proteins.
B. Tracy Nixon
Professor of Biochemistry and Molecular Biology
Structural and functional basis of cellulose synthesis. Using Physcomitrella patens and other organisms as model systems, we are learning how plants make cellulose for building new cell wall. The studies use methods of molecular biology and cryoEM to characterize the enzyme as a monomer, and when it assembles into its larger 'Cellulose Synthase Complex '(CSC for short). The aim is to understand cellulose synthesis to explain fundamentals of cell wall biology in plants, and to enable manipulation of its synthesis for applications in fields of bioenergy and materials.
Kristin Eckert
Professor of Pathology and Laboratory Medicine and of Biochemistry and Molecular Biology
Mechanisms of human cell mutagenesis and repetitive DNA replication in relation to genome evolution.
Gary Perdew
Director of the Center for Molecular Toxicology and Carcinogenesis; H. Thomas and Dorothy Willits Hallowell Chair in Agricultural Sciences
Mechanisms of receptor-mediated carcinogenesis.
Wayne Curtis
Professor of Chemical Engineering
Regulation and signal transduction in plant secondary metabolism. Phytoremediation of hydrocarbons. Commercial chemical production in plants and plant tissue culture.
David Eissenstat
Professor of Woody Plant Physiology
Plant physiological ecology. Root biology and physiology. Plant carbon and nutrient economies.
Craig Meyers
Distinguished Professor of Microbiology and Immunology
The differentiation-dependent life cycle of human papillomavirus (HPV) and HPV-associated oncogenesis.
Sarah Ades
Professor of Biochemistry & Molecular Biology; Associate Dean of The Graduate School
Signal transduction and antibiotic-induced stress responses in bacteria.
Mary Ann Bruns
Professor of Soil Microbiology and Biogeochemistry
Compositions and functions of microbiomes in agriculture, ecological restoration, and engineered systems for ecosystem service provision and climate change adaptation
Colin Barnstable
Professor and Chair of Neural Behavioral Sciences
How interacting networks of transcription factors and signal transduction molecules guide the development of precursor/stem cells into mature neurons. Role of these networks in neurodegenerative diseases. Factors that can act as neuroprotective agents.
Duane Diefenbach
Adjunct Professor of Wildlife Ecology
Wildlife ecology, estimation of population parameters, and harvest management of game populations.
James Adair
Professor of Material Science and Engineering
Nanoscale materials and phenomena for biological, optical and structural applications, property manipulation via novel chemical pathways for designer particles and materials, colloid and interfacial chemistry, powder characterization, powder processing, and commercialization and regulatory pathways for nanomedical human healthcare formulations
James Broach
Distinguished Professor and Chair of Biochemistry and Molecular Biology
Sinisa Dovat
Professor and Vice Chair for Basic Science Research, Department of Pediatrics; Professor of Biochemistry and Molecular Biology and of Pharmacology
Investigate the role of lymphoid master regulator, IKZF1/Ikaros, in the development of acute lymphoblastic leukemia (ALL); other transcriptional factors in leukemia; CK2 activity; chromatin remodeling; super-enhancers.
Idan Shalev
Assistant Professor of Biobehavioral Health
Interdisciplinary approach to identify mechanisms underpinning the biological embedding of stress across the lifespan with a special focus on biological aging.
Armen Kemanian
Professor of Production Systems and Modeling
Agricultural Systems, Agricultural and Natural Systems Modeling, Soil Carbon and Nitrogen Cycling, Bioenergy Systems, Coupled Hydrologic and Nutrient Modeling, and Plant Competition
Yong Wang
Professor of Biomedical Engineering
Applying nature and biology as design guidelines to the creation of biomimetic and bioinspired materials at both the nanoscale and macroscale level for drug delivery, clinical diagnosis, and regenerative medicine.
Center for Infectious Disease Dynamics
Erin Connolly
Professor and Head of Plant Science
Molecular mechanisms of micronutrient transport. Iron uptake and compartmentalization. Metal ion homeostasis
Daniel Hayes
Director, Center of Excellence in Industrial Biotechnology; Huck Chair in Nanotherapeutics and Regenerative Medicine; Professor of Biomedical Engineering
Biomaterials engineering for applications ranging from regenerative medicine to lab-on-a-chip technologies. An emphasis on nanomaterials, macromolecules and composite structures. Ongoing efforts include development of optically and magnetically modulated drug delivery systems, quasi 3D cell sheet culture systems, cell encapsulation and delivery materials and hybrid in situ polymerizing grafts/augments.
Neela Yennawar
Director, X-Ray Crystallography and Automated Biological Calorimetry Core Facilities; Research Professor
Biological calorimetry, protein characterization, molecular modeling, X-ray crystallography, and small-angle X-ray scattering.
Nikolay Dokholyan
G. Thomas Passananti Professor of Pharmacology; Professor of Biochemistry and Molecular Biology
We are a translational systems research group in the Pharmacology at the Penn State College of Medicine. Our laboratory focuses on understanding etiologies of human diseases, such as cystic fibrosis (CF), amyotrophic lateral sclerosis (ALS), and pain conditions, such as hyperalgesia.
Center for Infectious Disease Dynamics
Suzanne Gonzalez
Assistant Professor of Psychiatry and Behavioral Health and of Pharmacology
My laboratory
focuses on neuropsychiatric genetics in diverse populations. I am particularly
interested in understanding how genetic polymorphisms within key physiological
pathways translate into clinical phenotypes of psychiatric disorders, such as
bipolar disease and schizophrenia.
Yifei Huang
Assistant Professor of Biology
Developing novel bioinformatic methods and using them to address fundamental questions in evolutionary genomics and medical genomics.
Katsuhiko Murakami
Professor of Biochemistry and Molecular Biology
Structural and Mechanistic Enzymology of Prokaryotic RNA Polymerases
Deb Kelly
Director of the Center for Structural Oncology; Huck Chair in Molecular Biophysics; Professor of Biomedical Engineering
Engineering new molecular paradigms to create a world without cancer.
Gary Thompson
Associate Dean for Research and Graduate Education, College of Agricultural Sciences; Director, PA Agricultural Experiment Station
Jean-Paul Armache
Assistant Professor of of Biochemistry and Molecular Biology
The mechanisms and functions of ATP-dependent chromatin remodeling complexes and their place in gene regulation.
Center for Infectious Disease Dynamics
Erika Ganda
Assistant Professor of Food Animal Microbiomes
Developing practical ways to leverage the microbiome to improve food safety and improve food production animals' production efficiency.
Center for Infectious Disease Dynamics
Emily Davenport
Assistant Professor of Biology
Understanding the complex relationship humans have with our microbiomes, using high-throughput sequencing technologies and novel computational and statistical techniques.
Joshua Kellogg
Emphasis Area Representative, Molecular Toxicology; Assistant Professor of Veterinary and Biomedical Sciences
Development of new metabolomics tools for chemical and biological characterization of complex systems. Discovery of new natural products from plants and microorganisms with novel bioactivity against pathogenic fungi and neglected tropical diseases. Bioanalytical techniques to probe the mechanism of action and basic biology of these target organisms. Ethnobotany and indigenous knowledge surrounding plant-based medicine.
Stephen Benkovic
Evan Pugh University Professor and Eberly Chair in Chemistry
Squire Booker
Evan Pugh Professor of Chemistry; Professor of Biochemistry and Molecular Biology
Elucidating the chemical mechanisms by which enzymes containing iron-sulfur clusters catalyze chemical reactions. Most ongoing projects deal with members of the Radical S-adenosylmethionine Superfamily, a diverse group of enzymes that employ radical chemistry to catalyze transformations involved in post-transcriptional and post-translational modifications, cofactor biosynthesis, secondary metabolite biosynthesis, and enzyme activation.
Will Dearnaley
Technical Director, Dept. of Biomedical Engineering & Center for Structural Oncology
Estelle Couradeau
Assistant Professor of Ecosystem Science & Management
Denise Okafor
Assistant Professor of Biochemistry and Molecular Biology
Structural mechanisms of signaling and regulation in protein complexes.
Sharifa Crandall
Assistant Professor of Plant Pathology and Environmental Microbiology
Drawing from community ecology theory to understand how fungal and oomycete pathogens shape plant disease dynamics, with a focus on root and soil microbiome diversity, structure, and function; how ecological disturbances drive the complex interactions between hosts, microbes, and the environment across time and space and using this information to inform plant disease management.
Amir Sheikhi
Assistant Professor of Chemical Engineering
Micro- and nanoengineered soft materials for medicine and the environment; microfluidic-enabled biomaterials for tissue engineering and regeneration; living materials; next-generation bioadhesives, tissue sealants, and hemostatic agents; hydrogels for minimally invasive medical technologies; self-healing and adaptable soft materials; smart coatings; hairy nanocelluloses as an emerging family of advanced materials.
Justin Silverman
Assistant Professor of Information Sciences and Technology
Statistical methods for the analysis of biomedical data (or any other interesting data/questions)
Center for Infectious Disease Dynamics
Zachary Szpiech
Assistant Professor of Biology
Population and evolutionary genetics, with applications to medical genetics, anthropology, and conservation
Tae Hyun Kim
Huck Early Career Chair; Assistant Professor of Avian Biology
Improving poultry health by applying modern genetic approaches including gene editing. Particular focus on identifying key genes and regulatory elements associated with improved economic traits.
Ruobo Zhou
Assistant Professor of Chemistry
Quantitatively and functionally understanding the compartmentalization and spatiotemporal organization of protein-protein and protein-RNA interactions involved in fundamental cell functions as well as in cancer and neurodegenerative diseases.
Amie Boal
Professor of Chemistry and of Biochemistry and Molecular Biology
The structural differences between members of large metalloenzyme superfamilies that share common features but promote different reactions or use distinct cofactors.
Jordan Bisanz
Assistant Professor of Biochemistry and Molecular Biology
The interface of microbiology and bioinformatics, with approaches including genomics and metabolomics to investigate the interplay of diet, drugs, and the gut microbiome.
Parisa Kalantari
Assistant Professor of Immunology
Host-parasite interactions using Schistosoma mansoni-induced liver inflammation in mouse models. Modulation of immune responses by the parasite as well as the role of inflammasomes in inducing schistosomiasis.
Christian Huber
Assistant Professor of Biology
How evolutionary mechanisms such as mutation, recombination, and natural selection shape genetic diversity and the variability between individuals and species.
Melanie McReynolds
Huck Early Career Chair in Biochemistry and Molecular Biology; Assistant Professor of Biochemistry and Molecular Biology
The biochemistry behind aging and its intersection with stress, with the long-term goal of identifying strategies that promote healthier aging.
Guilherme Becker
Associate Professor of Biology
Host-microbial interactions, landscape genetics and the ecology of global change stressors. Building models and conducting field and laboratory experiments to understand the biotic and abiotic mechanisms driving wildlife disease dynamics in both tropical and temperate systems.
Center for Infectious Disease Dynamics
Seth Bordenstein
Director of the Microbiome Center; Huck Chair in Microbiome Sciences; Professor of Biology and Entomology
The evolutionary and genetic principles that shape symbiotic interactions between animals, microbes, and viruses and the major applications of these interactions to human health.
Dino Ravnic
Huck Chair in Regenerative Medicine and Surgical Sciences; Associate Professor of Surgery
Ilias Georgakopoulos-Soares
Assistant Professor
The development and implementation of new computational methods in genomics and molecular biology, with the aim of identifying genetic biomarkers for the diagnosis, monitoring, and treatment of human diseases, including bacterial and viral infections and of aging-associated diseases including neurodegenerative diseases and cancer.