65 People Results for the Tag: Degradation
Associate Professor of Biology and Entomology
Applies genomic, transcriptomic, phylogenomic, and bioinformatic approaches to study the evolution and genetics of diverse traits in bees and wasps. This includes study of mimetic color diversification, plant gall induction, novel morphologies, speciation, and social evolution.
Associate Professor of Biology
Regulation of neurogenesis using cellular and mouse models; analysis of abnormal neural progenitor cell (NPC) proliferation and its relationship to mental illnesses; identification of drugs that can reverse mouse models of psychiatric disorders.
Assistant Professor of Entomology
Evolution of chemical and structural defense. Molecular evolution, evolutionary genomics, and transcriptomics. Origins and evolution of carnivorous plants.
Huck Chair in Regenerative Engineering; Professor of Bioengineering
Development of new biodegradable polymers for use in engineering elastic tissues such as blood vessel, tendon, ligament, and cardiac tissue, and in other applications such as biological labeling, bioimaging and drug delivery.
Co-Director, Center for RNA Molecular Biology; Distinguished Professor of Chemistry and Biochemistry & Molecular Biology
RNA folding in vivo and genome-wide; RNA regulation of gene expression; Ribozyme Mechanism; roles RNA may have played in the emergence of life on early earth
Chair, Intercollege Graduate Degree Program in Plant Biology; Distinguished Professor of Biochemistry and Molecular Biology
Molecular, biochemical, and structural bases of the S-RNase-based self-incompatibility system in flowering plants. F-box protein-mediated ubiquitination and degradation of proteins.
Professor of Biochemistry and Molecular Biology
Structural and functional basis of cellulose synthesis. Using Physcomitrella patens and other organisms as model systems, we are learning how plants make cellulose for building new cell wall. The studies use methods of molecular biology and cryoEM to characterize the enzyme as a monomer, and when it assembles into its larger 'Cellulose Synthase Complex '(CSC for short). The aim is to understand cellulose synthesis to explain fundamentals of cell wall biology in plants, and to enable manipulation of its synthesis for applications in fields of bioenergy and materials.
Professor of Biochemistry & Molecular Biology
Characterization and biochemical analysis of cellulose synthesis in a variety of organisms. Mechanism and regulation of fungal degradation of lignin. Dissimilatory Iron reduction.
Professor of Immunology and Molecular Toxicology
Molecular mechanisms by which bioactives such as selenium, omega-3 fatty acids, and other products of natural origin alter the host response and immune function in inflammation and cancer
Adjunct Asst. Professor of Wildlife Ecology; Leader, PA Coop. Fish and Wildlife Research Unit
Wildlife ecology, estimation of population parameters, and harvest management of game populations.
Associate Professor of Biology
In vivo imaging of plant cell wall dynamics. Molecular genetic analysis of genes involved in cell growth. Cell wall biosynthesis in dividing cells. Cell wall engineering for sustainable bioenergy production.
Associate Professor of Kinesiology
Integrating experimental and modeling approaches to study gait and skeletal muscle function during locomotion in both health and disease/impairment. In particular, the relationship between in vivo muscle mechanics and metabolic energetics and mechanisms underlying locomotor adaptation and optimization.
Professor of Biomedical Engineering
Applying nature and biology as design guidelines to the creation of biomimetic and bioinspired materials at both the nanoscale and macroscale level for drug delivery, clinical diagnosis, and regenerative medicine.
Assistant Professor of Chemistry; Assistant Professor of Biochemistry and Molecular Biology; Paul Berg Early Career Professorship in the Eberly College of Science
Developing chemical tools to monitor cellular stresses that influence protein folding in real time. Deciphering how the energy landscapes associated with proper protein folding and function are regulated by the cellular folding environment. Examining how this regulation leads to significant biological consequences.
Dorothy Foehr Huck and J. Lloyd Huck Chair in Nanotherapeutics and Regenerative Medicine, Associate Professor of Biomedical Engineering
Biomaterials engineering for applications ranging from regenerative medicine to lab-on-a-chip technologies. An emphasis on nanomaterials, macromolecules and composite structures. Ongoing efforts include development of optically and magnetically modulated drug delivery systems, quasi 3D cell sheet culture systems, cell encapsulation and delivery materials and hybrid in situ polymerizing grafts/augments.
Assistant Professor of Biomedical Engineering
Design of bio-inspired functional materials that serve as new tools in precision medicine. Understanding how peptides and proteins assemble at natural and non-natural interfaces to form organized structures with unique biochemical functions. The design of nano- and micro-scale biomaterials to develop new biosensing and therapeutic strategies to treat infectious disease, inflammation and cancer.
Professor of Geography
Land use and agricultural change/global change, Economic development/globalization/neoliberalism, Nature-society and human-environment theory, Environmental impacts (biodiversity/soils/water/conservation), Food/producer-consumer networks/sustainability.
Microbial biomineralization with a focus on deciphering the molecular mechanisms involved in the formation of minerals by bacteria, the impact of this process on the geochemical cycles of different element (C, P, S, Fe), and the use of microbial biominerals as biosignatures in the rock record and in astrobiological contexts.
Associate Professor of Biochemistry and Molecular Biology
The mechanisms by which bacteria sense and respond to the environment, as well as how these signaling proteins/pathways affect competition, host colonization, and pathogenesis.