40 People Results for the Tag: Binding Sites

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Susan Hafenstein

Director of the Center for Structural Biology; Huck Chair of Structural Virology; Professor of Biochemistry and Molecular Biology
Using a structural approach to learn more about viral infectivity, tropism, evolution and pathogenicity. Developing approaches to visualize critical events that cause a break from the regular symmetry of the virus, including packaging of the genome, receptor usage, antibody interactions and uncoating of the viral genome during the final stages of infection.

Center for Infectious Disease Dynamics

Mark Hedglin

Assistant Professor of Chemistry; Assistant Professor of Biochemistry and Molecular Biology
Deciphering how efficient and faithful replication of the human genome is achieved within the highly-complex, dynamic, and reactive environment of the nucleus. Identifying pathways for genomic instability in humans, identifying novel oncogenic drug targets, developing better chemotherapeutic treatments for human cancers caused by genomic instability.

Joyce Jose

Assistant Professor of Biochemistry & Molecular Biology
Virus-host interactions involved in the pathogenesis of alphaviruses and flaviviruses. Analysis of virus induced structures and cytoskeletal modifications in mammalian host and insect vector using high-resolution live cell imaging and electron microscopy. Viral determinants of neurotropism, encephalitis, transmission and persistence in BSL-3 pathogens.

Center for Infectious Disease Dynamics

Andrey Krasilnikov

Associate Professor of Biochemistry and Molecular Biology
Structural biology of RNA and RNA-protein complexes

Cooduvalli Shashikant

Former Chair, Intercollege Graduate Degree Program in Bioinformatics and Genomics
Developmental and evolutionary aspects of regulation of patterning genes.

Andrew Zydney

Director of the Center for Industrial Biotechnology; Distinguished Professor of Chemical Engineering

Arthur Lesk

Professor of Biology and of Biochemistry & Molecular Biology

Ayusman Sen

Distinguished Professor of Chemistry

Howard Salis

Associate Professor of Chemical Engineering; Associate Professor of Agricultural and Biological Engineering
Engineering microorganisms for applications in synthetic biology and metabolic engineering.

Lu Bai

Associate Professor of Biochemistry and Molecular Biology; Associate Professor of Physics
Single cell / single molecule study of chromatin and gene regulation.

Paul Babitzke

Co-Director of the Center for RNA Molecular Biology; Professor of Biochemistry and Molecular Biology
Regulation of gene expression by RNA structure and RNA-binding proteins

Ross Hardison

Associate Director of the Genome Sciences Institute; T. Ming Chu Professor of Biochemistry and Molecular Biology
Regulation of gene expression during development.

Shaun Mahony

Associate Professor of Biochemistry & Molecular Biology
We apply neural networks and other machine learning approaches to understand how transcription factors control cellular identity

John Golbeck

Professor of Biochemistry and Biophysics
Light reactions in photosynthesis. Structure and function of photosystem I and the heliobacterial reaction center. Regulation and bioassembly of iron-sulfur clusters in cyanobacteria and plants. Plant and bacterial metalloproteins. Generation using Photosystem I, hydrogenase, and molecular wire technology.

Regina Vasilatos-Younken

Dean of the Graduate School; Professor of Poultry Science, Endocrine Physiology, and Nutrition
Role of endocrine and metabolic factors in the regulation of muscle and adipose tissue growth.

Pamela Mitchell

Emeritus Associate Professor of Biology

Sarah Ades

Associate Professor of Biochemistry & Molecular Biology; Associate Dean of The Graduate School
Signal transduction and antibiotic-induced stress responses in bacteria.

Colin Barnstable

Professor and Chair of Neural Behavioral Sciences
How interacting networks of transcription factors and signal transduction molecules guide the development of precursor/stem cells into mature neurons. Role of these networks in neurodegenerative diseases. Factors that can act as neuroprotective agents.

John Wills

Distinguished Professor of Microbiology and Immunology

Jeffery Sample

Professor of Microbiology

Sinisa Dovat

Professor and Vice Chair for Basic Science Research, Department of Pediatrics; Professor of Biochemistry and Molecular Biology and of Pharmacology
Investigate the role of lymphoid master regulator, IKZF1/Ikaros, in the development of acute lymphoblastic leukemia (ALL); other transcriptional factors in leukemia; CK2 activity; chromatin remodeling; super-enhancers.

Neela Yennawar

Director, X-Ray Crystallography and Automated Biological Calorimetry Core Facilities; Associate Research Professor
Biological calorimetry, protein characterization, molecular modeling, X-ray crystallography, and small-angle X-ray scattering.

Yasser El-Manzalawy

Assistant Research Professor of Information Sciences and Technology

Squire Booker

Evan Pugh Professor of Chemistry; Professor of Biochemistry and Molecular Biology
Elucidating the chemical mechanisms by which enzymes containing iron-sulfur clusters catalyze chemical reactions. Most ongoing projects deal with members of the Radical S-adenosylmethionine Superfamily, a diverse group of enzymes that employ radical chemistry to catalyze transformations involved in post-transcriptional and post-translational modifications, cofactor biosynthesis, secondary metabolite biosynthesis, and enzyme activation.

Katsuhiko Murakami

Professor of Biochemistry and Molecular Biology
Structural and Mechanistic Enzymology of Prokaryotic RNA Polymerases

Deb Kelly

Director of the Center for Structural Oncology; Huck Chair in Molecular Biophysics; Professor of Biomedical Engineering
Engineering new molecular paradigms to create a world without cancer.

Tami Mysliwiec

Associate Professor of Biology

Gary Thompson

Associate Dean for Research and Graduate Education, College of Agricultural Sciences; Director, PA Agricultural Experiment Station

Jean-Paul Armache

Assistant Professor of of Biochemistry and Molecular Biology
The mechanisms and functions of ATP-dependent chromatin remodeling complexes and their place in gene regulation.

Center for Infectious Disease Dynamics

Will Dearnaley

Technical Director, Dept. of Biomedical Engineering & Center for Structural Oncology

Yao Guo

Research Assistant - Luscher Lab

Guy Townsend

Assistant Professor of Biochemistry and Molecular Biology

Adele Turzillo

Professor and Department Head of Animal Science

Ganesh Srinivasan Anand

Associate Professor of Chemistry
Dynamics of large biomolecular complexes; uncovering what drives their assembly, regulation and function through mass spectrometry.

Center for Infectious Disease Dynamics

Amie Boal

Associate Professor of Chemistry and of Biochemistry and Molecular Biology
The structural differences between members of large metalloenzyme superfamilies that share common features but promote different reactions or use distinct cofactors.