Susan Hafenstein
Huck Chair of Structural Biology; Associate Professor of Biochemistry and Molecular Biology
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Using a structural approach to learn more about viral infectivity, tropism, evolution and pathogenicity. Developing approaches to visualize critical events that cause a break from the regular symmetry of the virus, including packaging of the genome, receptor usage, antibody interactions and uncoating of the viral genome during the final stages of infection.
Education
- Ph.D., University of Arizona, Tucson, AZ, 2003
- B.S., Louisiana State University, Baton Rouge, LA, 1992
Huck Graduate Students
Publication Tags
Capsid Genome Parvovirus Infection Mutation Viruses Protoparvovirus Virion Antibodies Cryoelectron Microscopy Receptors Capsid Proteins Human Papillomavirus 16 Canine Parvovirus Cells Transferrin Receptors Dogs Binding Sites Host Specificity Divalent Cations Host Range Minute Virus Of Mice Mastadenovirus Enterovirus Heparin
Most Recent Papers
Transferrin receptor binds virus capsid with dynamic motion
Hyunwook Lee, Heather M. Callaway, Javier O. Cifuente, Carol M. Bator, Colin R. Parrish, Susan L. Hafenstein, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 20462-20471
Parvovirus B19 uncoating occurs in the cytoplasm without capsid disassembly and it is facilitated by depletion of capsid-associated divalent cations
Oliver Caliaro, Andrea Marti, Nico Ruprecht, Remo Leisi, Suriyasri Subramanian, Susan Hafenstein, Carlos Ros, 2019, Viruses on p. 430
Examination and reconstruction of three ancient endogenous parvovirus capsid protein gene remnants found in rodent genomes
Heather M. Callaway, Suriyasri Subramanian, Christian A. Urbina, Karen N. Barnard, Robert A. Dick, Carol M. Bator, Susan L. Hafenstein, Robert J. Gifford, Colin R. Parrish, 2019, Journal of virology
Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus - A 71 capsid
Liang Sun, Hyunwook Lee, Hendrik Jan Thibaut, Kristina Lanko, Eva Rivero-Buceta, Carol Bator, Belen Martinez-Gualda, Kai Dallmeier, Leen Delang, Pieter Leyssen, Federico Gago, Ana San-Felix, Susan Hafenstein, Carmen Mirabelli, Johan Neyts, 2019, PLoS pathogens
Complex and dynamic interactions between parvovirus capsids, transferrin receptors, and antibodies control cell infection and host range
Heather M. Callaway, Kathrin Welsch, Wendy Weichert, Andrew B. Allison, Susan L. Hafenstein, Kai Huang, Sho Iketani, Colin R. Parrish, 2018, Journal of virology
Nuclear, cytosolic, and surface-localized poly(A)-binding proteins of Plasmodium yoelii
Allen M. Minns, Kevin J. Hart, Suriyasri Subramanian, Susan Hafenstein, Scott E. Lindner, 2018, mSphere
Cryo-EM maps reveal five-fold channel structures and their modification by gatekeeper mutations in the parvovirus minute virus of mice (MVM) capsid
Suriyasri Subramanian, Lindsey J. Organtini, Alec Grossman, Phillip P. Domeier, Javier O. Cifuente, Alexander M. Makhov, James F. Conway, Anthony D'Abramo, Susan F. Cotmore, Peter Tattersall, Susan Hafenstein, 2017, Virology on p. 216-223
Cryoelectron Microscopy Maps of Human Papillomavirus 16 Reveal L2 Densities and Heparin Binding Site
Jian Guan, Stephanie M. Bywaters, Sarah A. Brendle, Robert E. Ashley, Alexander M. Makhov, James F. Conway, Neil D. Christensen, Susan Hafenstein, 2017, Structure on p. 253-263
MOPS and coxsackievirus B3 stability
Steven D. Carson, Susan Hafenstein, Hyunwook Lee, 2017, Virology on p. 183-187
Parvovirus capsid structures required for infection
Heather M. Callaway, Kurtis H. Feng, Donald W. Lee, Andrew B. Allison, Melissa Pinard, Robert McKenna, Mavis Agbandje-McKenna, Susan Hafenstein, Colin R. Parrish, 2017, Journal of virology
Recent Most-Cited Papers
Secretion of genome-free hepatitis b virus - single strand blocking model for virion morphogenesis of para-retrovirus
Xiaojun Ning, David Nguyen, Laura Mentzer, Christina Adams, Hyunwook Lee, Robert Ashley, Susan Hafenstein, Jianming Hu, 2011, PLoS pathogens
Depletion of virion-associated divalent cations induces parvovirus minute virus of mice to eject its genome in a 3′ -to-5′ direction from an otherwise intact viral particle
Susan F. Cotmore, Susan Hafenstein, Peter Tattersall, 2010, Journal of virology on p. 1945-1956
Structural comparison of four different antibodies interacting with human papillomavirus 16 and mechanisms of neutralization
Jian Guan, Stephanie M. Bywaters, Sarah A. Brendle, Hyunwook Lee, Robert E. Ashley, Alexander M. Makhov, James F. Conway, Neil Christensen, Susan Hafenstein, 2015, Virology on p. 253-263
Cryoelectron Microscopy Maps of Human Papillomavirus 16 Reveal L2 Densities and Heparin Binding Site
Jian Guan, Stephanie M. Bywaters, Sarah A. Brendle, Robert E. Ashley, Alexander M. Makhov, James F. Conway, Neil D. Christensen, Susan Hafenstein, 2017, Structure on p. 253-263
Assembly and characterization of foot-and-mouth disease virus empty capsid particles expressed within mammalian cells
Maria Gullberg, Bartosz Muszynski, Lindsey J. Organtini, Robert E. Ashley, Susan L. Hafenstein, Graham J. Belsham, Charlotta Polacek, 2013, Journal of General Virology on p. 1769-1779
Single mutations in the VP2 300 loop region of the three-fold spike of the carnivore parvovirus capsid can determine host range
Andrew B. Allison, Lindsey J. Organtini, Sheng Zhang, Susan L. Hafenstein, Edward C. Holmes, Colin R. Parrish, 2016, Journal of virology on p. 753-767
Evolution and cryo-electron microscopy capsid structure of a north american bat adenovirus and its relationship to other mastadenoviruses
Nicole Hackenbrack, Matthew B. Rogers, Robert E. Ashley, M. Kevin Keel, Steven V. Kubiski, John A. Bryan, Elodie Ghedin, Edward C. Holmes, Susan L. Hafenstein, Andrew B. Allison, 2017, Journal of virology
Near-atomic resolution structure of a highly neutralizing fab bound to canine parvovirus
Lindsey J. Organtini, Hyunwook Lee, Sho Iketani, Kai Huang, Robert E. Ashley, Alexander M. Makhov, James F. Conway, Colin R. Parrish, Susan Hafenstein, 2016, Journal of virology on p. 9733-9742
Honey bee deformed wing virus structures reveal that conformational changes accompany genome release
Lindsey J. Organtini, Kristin L. Shingler, Robert E. Ashley, Elizabeth A. Capaldi, Kulsoom Durrani, Kelly A. Dryden, Alexander M. Makhov, James F. Conway, Marie C. Pizzorno, Susan Hafenstein, 2017, Journal of virology
Parvovirus capsid structures required for infection
Heather M. Callaway, Kurtis H. Feng, Donald W. Lee, Andrew B. Allison, Melissa Pinard, Robert McKenna, Mavis Agbandje-McKenna, Susan Hafenstein, Colin R. Parrish, 2017, Journal of virology