Bio
Using a structural approach to learn more about viral infectivity, tropism, evolution and pathogenicity. Developing approaches to visualize critical events that cause a break from the regular symmetry of the virus, including packaging of the genome, receptor usage, antibody interactions and uncoating of the viral genome during the final stages of infection.
Education
- Ph.D., University of Arizona, Tucson, AZ, 2003
- B.S., Louisiana State University, Baton Rouge, LA, 1992
Graduate Students
Publication Tags
Capsid Genome Viruses Enterovirus Cryoelectron Microscopy Antibodies Virion Epitopes Parvovirus Mutation Infection Neutralizing Antibodies Cryo Electron Microscopy Human Papillomavirus 16 Protoparvovirus Minute Virus Of Mice Immunoglobulin Fragments Dna Receptors Adenoviridae Mastadenovirus Rodent Protoparvovirus 1 Picornaviridae Rna Crystal Structure
Most Recent Papers
Examination and reconstruction of three ancient endogenous parvovirus capsid protein gene remnants found in rodent genomes
Heather M. Callaway, Suriyasri Subramanian, Christian A. Urbina, Karen N. Barnard, Robert A. Dick, Carol M. Bator, Susan Hafenstein, Robert J. Gifford, Colin R. Parrish, 2019, Journal of virology
Complex and dynamic interactions between parvovirus capsids, transferrin receptors, and antibodies control cell infection and host range
Heather M. Callaway, Kathrin Welsch, Wendy Weichert, Andrew B. Allison, Susan Hafenstein, Kai Huang, Sho Iketani, Colin R. Parrish, 2018, Journal of virology
Nuclear, cytosolic, and surface-localized poly(A)-binding proteins of Plasmodium yoelii
Allen M. Minns, Kevin J. Hart, Suriyasri Subramanian, Susan Hafenstein, Scott Eugene Lindner, 2018, mSphere
High-resolution structure analysis of antibody V5 and U4 conformational epitopes on human papillomavirus 16
Jian Guan, Stephanie M. Bywaters, Sarah A. Brendle, Robert E. Ashley, Alexander M. Makhov, James F. Conway, Neil Christensen, Susan Hafenstein, 2017, Viruses
Cryo-EM maps reveal five-fold channel structures and their modification by gatekeeper mutations in the parvovirus minute virus of mice (MVM) capsid
Suriyasri Subramanian, Lindsey J. Organtini, Alec Grossman, Phillip P. Domeier, Javier O. Cifuente, Alexander M. Makhov, James F. Conway, Anthony D'Abramo, Susan F. Cotmore, Peter Tattersall, Susan Hafenstein, 2017, Virology on p. 216-223
Cryoelectron Microscopy Maps of Human Papillomavirus 16 Reveal L2 Densities and Heparin Binding Site
Jian Guan, Stephanie M. Bywaters, Sarah A. Brendle, Robert E. Ashley, Alexander M. Makhov, James F. Conway, Neil Christensen, Susan Hafenstein, 2017, Structure on p. 253-263
MOPS and coxsackievirus B3 stability
Steven D. Carson, Susan Hafenstein, Hyunwook Lee, 2017, Virology on p. 183-187
Honey bee deformed wing virus structures reveal that conformational changes accompany genome release
Lindsey J. Organtini, Kristin L. Shingler, Robert E. Ashley, Elizabeth A. Capaldi, Kulsoom Durrani, Kelly A. Dryden, Alexander M. Makhov, James F. Conway, Marie C. Pizzorno, Susan Hafenstein, 2017, Journal of virology
Evolution and cryo-electron microscopy capsid structure of a north american bat adenovirus and its relationship to other mastadenoviruses
Nicole Hackenbrack, Matthew B. Rogers, Robert E. Ashley, M. Kevin Keel, Steven V. Kubiski, John A. Bryan, Elodie Ghedin, Edward C. Holmes, Susan Hafenstein, Andrew B. Allison, 2017, Journal of virology
Parvovirus capsid structures required for infection
Heather M. Callaway, Kurtis H. Feng, Donald W. Lee, Andrew B. Allison, Melissa Pinard, Robert McKenna, Mavis Agbandje-McKenna, Susan Hafenstein, Colin R. Parrish, 2017, Journal of Virology
Recent High-Impact Papers
Secretion of genome-free hepatitis b virus - single strand blocking model for virion morphogenesis of para-retrovirus
Xiaojun Ning, David Nguyen, Laura Mentzer, Christina Adams, Hyunwook Lee, Robert Ashley, Susan Hafenstein, Jianming Hu, 2011, PLoS Pathogens
The Enterovirus 71 A-particle Forms a Gateway to Allow Genome Release
Kristin L. Shingler, Jennifer L. Yoder, Michael S. Carnegie, Robert E. Ashley, Alexander M. Makhov, James F. Conway, Susan Hafenstein, 2013, PLoS Pathogens
Enterovirus 71 Binding to PSGL-1 on Leukocytes
Yorihiro Nishimura, Hyunwook Lee, Susan Hafenstein, Chikako Kataoka, Takaji Wakita, Jeffrey M. Bergelson, Hiroyuki Shimizu, 2013, PLoS Pathogens
Group Selection and Contribution of Minority Variants during Virus Adaptation Determines Virus Fitness and Phenotype
Antonio V. Bordería, Ofer Isakov, Gonzalo Moratorio, Rasmus Henningsson, Sonia Agüera-González, Lindsey Organtini, Nina F. Gnädig, Hervé Blanc, Andrés Alcover, Susan Hafenstein, Magnus Fontes, Noam Shomron, Marco Vignuzzi, 2015, PLoS Pathogens
A cryo-electron microscopy study identifies the complete H16.V5 epitope and reveals global conformational changes initiated by binding of the neutralizing antibody fragment
Hyunwook Lee, Sarah A. Brendle, Stephanie M. Bywaters, Jian Guan, Robert E. Ashley, Joshua D. Yoder, Alexander M. Makhov, James F. Conway, Neil Christensen, Susan Hafenstein, 2015, Journal of virology on p. 1428-1438
Depletion of virion-associated divalent cations induces parvovirus minute virus of mice to eject its genome in a 3′ -to-5′ direction from an otherwise intact viral particle
Susan F. Cotmore, Susan Hafenstein, Peter Tattersall, 2010, Journal of Virology on p. 1945-1956
A strain-specific epitope of enterovirus 71 identified by cryo-electron microscopy of the complex with fab from neutralizing antibody
Hyunwook Lee, Javier O. Cifuente, Robert E. Ashley, James F. Conway, Alexander M. Makhov, Yoshio Tano, Hiroyuki Shimizu, Yorihiro Nishimura, Susan Hafenstein, 2013, Journal of virology on p. 11363-11370
Structure of a packaging-defective mutant of minute virus of mice indicates that the genome is packaged via a pore at a 5-fold axis
Pavel Plevka, Susan Hafenstein, Lei Li, Anthony D'Abramo, Susan F. Cotmore, Michael G. Rossmann, Peter Tattersall, 2011, Journal of Virology on p. 4822-4827
Structural comparison of four different antibodies interacting with human papillomavirus 16 and mechanisms of neutralization
Jian Guan, Stephanie M. Bywaters, Sarah A. Brendle, Hyunwook Lee, Robert E. Ashley, Alexander M. Makhov, James F. Conway, Neil Christensen, Susan Hafenstein, 2015, Virology on p. 253-263
The crystal structure of a coxsackievirus B3-RD variant and a refined 9-angstrom cryo-electron microscopy reconstruction of the virus complexed with decay-accelerating factor (DAF) provide a new footprint of DAF on the virus surface
Joshua D. Yoder, Javier O. Cifuente, Jieyan Pan, Jeffrey M. Bergelson, Susan Hafenstein, 2012, Journal of Virology on p. 12571-12581