Suresh Kuchipudi

Huck Chair in Emerging Infectious Diseases, Clinical Associate Professor; Section Head Mammalian Virology & Immunology

Research Summary

Diagnostic Virology & Serology -Zoonotic and Emerging Viruses -Negative strand RNA viruses -Avian and Mammalian influenza -Immune responses to viruses -Viral pathogenesis Quantitative-omics approach to virus-host interactions

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Viruses Severe Acute Respiratory Syndrome Coronavirus Neutralizing Antibodies Chickens Ducks Virus Diseases Infection Protein Antibodies Liposomes Neutralization Immunotherapy Enzymes Infections Sars Virus Angiotensin Converting Enzyme 2 Cobalt Block Like Crystal Glass Comorbidity Kd Orthomyxoviridae Oligonucleotide Nanopores

Most Recent Papers

Mitigating the Impact of Emerging Animal Infectious Disease Threats

Suresh V. Kuchipudi, Deanna Behring, Ruth Nissly, Shubhada K. Chothe, Abhinay Gontu, Abirami Ravichandran, Ty Butler, 2022, Viruses

Transmission of SARS-CoV-2 from humans to a 16-year-old domestic cat with comorbidities in Pennsylvania, USA

Deepanker Tewari, Lore Boger, Steven Brady, Julia Livengood, Mary Lea Killian, Meera Surendran Nair, Nagaraja Thirumalapura, Suresh V. Kuchipudi, Corey Zellers, Betsy Schroder, Mia Torchetti, Ann Carpenter, Amber Kunkel, Kevin Brightbill, 2022, Veterinary Medicine and Science on p. 899-906

Multiple spillovers from humans and onward transmission of SARS-CoV-2 in white-tailed deer

Suresh V. Kuchipudi, Meera Surendran-Nair, Rachel M. Ruden, Michele Yon, Ruth H. Nissly, Kurt J. Vandegrift, Rahul K. Nelli, Lingling Li, Bhushan M. Jayarao, Costas D. Maranas, Nicole Levine, Katriina Willgert, Andrew J.K. Conlan, Randall J. Olsen, James J. Davis, James M. Musser, Peter John Hudson, Vivek Kapur, 2022, Proceedings of the National Academy of Sciences of the United States of America

Rapid detection of novel coronavirus SARS-CoV-2 by RT-LAMP coupled solid-state nanopores

Zifan Tang, Reza Nouri, Ming Dong, Jianbo Yang, Wallace Greene, Yusheng Zhu, Michele Yon, Meera Surendran Nair, Suresh V. Kuchipudi, Weihua Guan, 2022, Biosensors and Bioelectronics

Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice

Moustafa T. Mabrouk, Kevin Chiem, Edurne Rujas, Wei Chiao Huang, Dushyant Jahagirdar, Breandan Quinn, Meera Surendran Nair, Ruth H. Nissly, Victoria S. Cavener, Nina R. Boyle, Ty A. Sornberger, Suresh V. Kuchipudi, Joaquin Ortega, Jean Philippe Julien, Luis Martinez-Sobrido, Jonathan Lovell, 2021, Science advances

Limited window for donation of convalescent plasma with high live-virus neutralizing antibody titers for COVID-19 immunotherapy

Abhinay Gontu, Sreenidhi Srinivasan, Eric Salazar, Meera Surendran Nair, Ruth H. Nissly, Denver Greenawalt, Ian M. Bird, Catherine M. Herzog, Matthew J. Ferrari, Indira Poojary, Robab Katani, Scott E. Lindner, Allen M. Minns, Randall Rossi, Paul A. Christensen, Brian Castillo, Jian Chen, Todd N. Eagar, Xin Yi, Picheng Zhao, Christopher Leveque, Randall J. Olsen, David W. Bernard, Jimmy Gollihar, Suresh V. Kuchipudi, James M. Musser, Vivek Kapur, 2021, Communications Biology

Computational prediction of the effect of amino acid changes on the binding affinity between SARS-CoV-2 spike RBD and human ACE2

Chen Chen, Veda Sheersh Boorla, Deepro Banerjee, Ratul Chowdhury, Victoria S. Cavener, Ruth H. Nissly, Abhinay Gontu, Nina R. Boyle, Kurt Vandegrift, Meera Surendran Nair, Suresh V. Kuchipudi, Costas D. Maranas, 2021, Proceedings of the National Academy of Sciences of the United States of America

Innate lymphoid cells (ILC) in SARS-CoV-2 infection

Amrita Kumar, Weiping Cao, Kedan Endrias, Suresh V. Kuchipudi, Suresh K. Mittal, Suryaprakash Sambhara, 2021, Molecular Aspects of Medicine

Complete genome sequences of six staphylococcus pseudintermedius strains from dogs with superficial pyoderma in georgia, USA

Maurice Byukusenge, Frane Banovic, Lingling Li, Suresh V. Kuchipudi, Bhushan M. Jayarao, Cynthia K. Watson, Hemant K. Naikare, 2021, Microbiology Resource Announcements

Neutralizing Aptamers Block S/RBD-ACE2 Interactions and Prevent Host Cell Infection

Xiaohui Liu, Yi ling Wang, Jacky Wu, Jianjun Qi, Zihua Zeng, Quanyuan Wan, Zhenghu Chen, Pragya Manandhar, Victoria S. Cavener, Nina R. Boyle, Xinping Fu, Eric Salazar, Suresh V. Kuchipudi, Vivek Kapur, Xiaoliu Zhang, Michihisa Umetani, Mehmet Sen, Richard C. Willson, Shu hsia Chen, Youli Zu, 2021, Angewandte Chemie - International Edition on p. 10273-10278

Most-Cited Papers

18S rRNA is a reliable normalisation gene for real time PCR based on influenza virus infected cells

Suresh V. Kuchipudi, Meenu Tellabati, Rahul K. Nelli, Gavin A. White, Belinda Baquero Perez, Sujith Sebastian, Marek J. Slomka, Sharon M. Brookes, Ian H. Brown, Stephen P. Dunham, Kin Chow Chang, 2012, Virology Journal

Cytokines

Alti Dayakar, Sambamurthy Chandrasekaran, Suresh V. Kuchipudi, Suresh K. Kalangi, 2019, Frontiers in Immunology

Highly pathogenic avian influenza virus infection in chickens but not ducks is associated with elevated host immune and pro-inflammatory responses

Suresh V. Kuchipudi, Meenu Tellabati, Sujith Sebastian, Brandon Z. Londt, Christine Jansen, Lonneke Vervelde, Sharon M. Brookes, Ian H. Brown, Stephen P. Dunham, Kin Chow Chang, 2014, Annales de Recherches Veterinaires on p. 118

The Complex Role of STAT3 in Viral Infections

Suresh V. Kuchipudi, 2015, Clinical and Developmental Immunology

Heat shock protein 70 (Hsp70) mediates Zika virus entry, replication, and egress from host cells

Sujit Pujhari, Marco Brustolin, Vanessa M. Macias, Ruth H. Nissly, Masashi Nomura, Suresh V. Kuchipudi, Jason L. Rasgon, 2019, Emerging Microbes and Infections on p. 8-16

Rapid death of duck cells infected with influenza

Suresh V. Kuchipudi, Stephen P. Dunham, Rahul Nelli, Gavin AWhite, Vivien J. Coward, Marek J. Slomka, Ian H. Brown, Kin Chow Chang, 2012, Immunology and Cell Biology on p. 116-123

SARS-CoV-2 RBD Neutralizing Antibody Induction is Enhanced by Particulate Vaccination.

Wei Chiao Huang, Shiqi Zhou, Xuedan He, Kevin Chiem, Moustafa T. Mabrouk, Ruth H. Nissly, Ian M. Bird, Mike Strauss, Suryaprakash Sambhara, Joaquin Ortega, Elizabeth A. Wohlfert, Luis Martinez-Sobrido, Suresh V. Kuchipudi, Bruce A. Davidson, Jonathan F. Lovell, 2020, Advanced Materials on p. e2005637

Pathogenicity and tissue tropism of infectious bronchitis virus is associated with elevated apoptosis and innate immune responses

Rajesh Chhabra, Suresh V. Kuchipudi, Julian Chantrey, Kannan Ganapathy, 2016, Virology on p. 232-241

A simplified but robust method for the isolation of avian and mammalian muscle satellite cells

Belinda Baquero-Perez, Suresh V. Kuchipudi, Rahul K. Nelli, Kin Chow Chang, 2012, BMC Cell Biology

Neutralizing Aptamers Block S/RBD-ACE2 Interactions and Prevent Host Cell Infection

Xiaohui Liu, Yi ling Wang, Jacky Wu, Jianjun Qi, Zihua Zeng, Quanyuan Wan, Zhenghu Chen, Pragya Manandhar, Victoria S. Cavener, Nina R. Boyle, Xinping Fu, Eric Salazar, Suresh V. Kuchipudi, Vivek Kapur, Xiaoliu Zhang, Michihisa Umetani, Mehmet Sen, Richard C. Willson, Shu hsia Chen, Youli Zu, 2021, Angewandte Chemie - International Edition on p. 10273-10278

News Articles Featuring Suresh Kuchipudi

Kuchipudi receives College of Ag Sciences award for research innovation

Suresh Kuchipudi, Dorothy Foehr Huck and J. Lloyd Huck Chair in Emerging Infectious Diseases, is the 2022 recipient of the Research Innovator of the Year Award, given by Penn State’s College of Agricultural Sciences to recognize faculty and staff who have made notable efforts to commercialize their Penn State research.

COVID is spreading in deer. What does that mean for the pandemic?

Hundreds of white-tailed deer in North America have tested positive for SARS-CoV-2. Here’s why scientists aren’t panicking, yet.

Preventing, controlling spread of animal diseases focus of forum at Penn State

Exploring the emergence, spread and control of animal infectious diseases was the focus of the inaugural Emerging Animal Infectious Disease Conference held Nov. 29-Dec.1, 2021, at Penn State. It was hosted by the College of Agricultural Sciences, the Pennsylvania Department of Agriculture, and Penn State’s Center for Security Research and Education.

Into The Wild: Animals the Latest Frontier in COVID Fight

Scientists are concerned that the virus could evolve within animal populations – potentially spawning dangerous viral mutants that could jump back to people, spread among us and reignite what for now seems to some people like a waning crisis.

COVID-19 has now been found in 29 kinds of animals, which has scientists concerned

Most animals do not spread COVID back to people. But as it continues to circulate, the virus could accumulate worrisome mutations.

The Coronavirus Menagerie

With the virus widespread in white-tailed deer, scientists wonder which animals might be next.

Omicron detected for first time in white-tailed deer

Some white-tailed deer living in Staten Island, New York, are actively infected with the Omicron (B.1.1.529) variant of SARS-CoV-2, according to new research led by scientists at Penn State. The team also found neutralizing antibodies to SARS-CoV-2 in one of the Omicron-infected deer, suggesting that, like humans, deer can be reinfected with the virus.

COVID-19 May Be Widespread in Deer

An analysis by Penn State and Iowa researchers found that Covid-19 may be fairly widespread among white-tailed deer. Up to 80 percent of the deer sampled in Iowa from April 2020 through January 2021 were infected with COVID-19. And The U.S. Department of Agriculture has confirmed Covid infections in deer in 15 states total.

The hamsters of Hong Kong offer a cautionary COVID tale

Hamsters can infect people with the coronavirus, which then goes on to spread among the human population — that's the assertion in a new study about the events of mid-January, when Hong Kong announced that at least three cases of COVID-19 were linked to hamsters in a pet store.

Omicron-Infected Whitetail Deer Detected in New York

The first cases of whitetail deer carrying the Omicron variant of the COVID-19 virus have been discovered in Staten Island, New York. Researchers there report that 19 of 131 deer sampled between December 12, 2021, and Janauary 31, 2022, tested positive for the virus’ antibodies, indicating prior exposure to the coronavirus. PCR (polymerase chain reaction) nasal swab testing of 68 deer revealed that seven were actively infected, with at least four of those confirmed to be Omicron.