Suresh Kuchipudi

Huck Chair in Emerging Infectious Diseases, Clinical Associate Professor; Section Head Mammalian Virology & Immunology

Research Summary

Diagnostic Virology & Serology -Zoonotic and Emerging Viruses -Negative strand RNA viruses -Avian and Mammalian influenza -Immune responses to viruses -Viral pathogenesis Quantitative-omics approach to virus-host interactions

Huck Affiliations

Links

Publication Tags

Viruses Swine Infection Chickens Neutralizing Antibodies Orthomyxoviridae Genes Proteins Virus Diseases Ducks Viral Load Poultry Immunoglobulin G Antibodies Real Time Polymerase Chain Reaction Immunotherapy Epithelial Cells Influenza A Virus Human Influenza Zoonoses Infections Cells Protein Influenza In Birds Polymerase Chain Reaction

Most Recent Papers

Limited window for donation of convalescent plasma with high live-virus neutralizing antibody titers for COVID-19 immunotherapy

Abhinay Gontu, Sreenidhi Srinivasan, Eric Salazar, Meera Surendran Nair, Ruth H. Nissly, Denver Greenawalt, Ian M. Bird, Catherine M. Herzog, Matthew J. Ferrari, Indira Poojary, Robab Katani, Scott E. Lindner, Allen M. Minns, Randall Rossi, Paul A. Christensen, Brian Castillo, Jian Chen, Todd N. Eagar, Xin Yi, Picheng Zhao, Christopher Leveque, Randall J. Olsen, David W. Bernard, Jimmy Gollihar, Suresh V. Kuchipudi, James M. Musser, Vivek Kapur, 2021, Communications Biology

Neutralizing Aptamers Block S/RBD-ACE2 Interactions and Prevent Host Cell Infection

Xiaohui Liu, Yi ling Wang, Jacky Wu, Jianjun Qi, Zihua Zeng, Quanyuan Wan, Zhenghu Chen, Pragya Manandhar, Victoria S. Cavener, Nina R. Boyle, Xinping Fu, Eric Salazar, Suresh V. Kuchipudi, Vivek Kapur, Xiaoliu Zhang, Michihisa Umetani, Mehmet Sen, Richard C. Willson, Shu hsia Chen, Youli Zu, 2021, Angewandte Chemie - International Edition on p. 10273-10278

A Highly Sensitive and Specific Probe-Based Real-Time PCR for the Detection of Avibacterium paragallinarum in Clinical Samples From Poultry

Suresh V. Kuchipudi, Michele Yon, Meera Surendran Nair, Maurice Byukusenge, Rhiannon M. Barry, Ruth H. Nissly, Jen Williams, Traci Pierre, Tammy Mathews, Eva Walner-Pendleton, Patricia Dunn, Denise Barnhart, Sean Loughrey, Sherrill Davison, Dona J. Kelly, Deepanker Tewari, Bhushan M. Jayarao, 2021, Frontiers in Veterinary Science

A Novel Real-Time PCR Assay for the Rapid Detection of Virulent Streptococcus equi Subspecies zooepidemicus—An Emerging Pathogen of Swine

Suresh V. Kuchipudi, Meera Surendran Nair, Michele Yon, Abhinay Gontu, Ruth H. Nissly, Rhiannon Barry, Denver Greenawalt, Traci Pierre, Lingling Li, Nagaraja Thirumalapura, Deepanker Tewari, Bhushan Jayarao, 2021, Frontiers in Veterinary Science

Genomic characterization of velogenic avian orthoavulavirus 1 isolates from poultry workers

Muhammad Zubair Shabbir, Ruth Helmus Nissly, Abdul Ahad, Masood Rabbani, Levina Lim, Shubhada K. Chothe, Murugan Subbiah, Aswathy Sebastian, Istvan Albert, Aziz Ul-Rahman, Bhushan M. Jayarao, Suresh V. Kuchipudi, 2021, Asian Pacific Journal of Tropical Medicine on p. 64-72

Sialic acid receptors

Suresh V. Kuchipudi, Rahul K. Nelli, Abhinay Gontu, Rashmi Satyakumar, Meera Surendran Nair, Murugan Subbiah, 2021, Viruses

Prevalence and distribution of multilocus sequence types of Staphylococcus aureus isolated from bulk tank milk and cows with mastitis in Pennsylvania

Asha Thomas, Shubhada Chothe, Maurice Byukusenge, Tammy Mathews, Traci Pierre, S Kariyawasam, Erin Luley, S Kuchipudi, B Jayarao, 2021, PLoS One

Influenza C and D viral load in cattle correlates with bovine respiratory disease (BRD)

Ruth H. Nissly, Noriza Zaman, Puteri Ainaa S. Ibrahim, Kaitlin McDaniel, Levina Lim, Jennifer N. Kiser, Ian Bird, Shubhada K. Chothe, Gitanjali L. Bhushan, Kurt Vandegrift, Holly L. Neibergs, Suresh V. Kuchipudi, 2020, Virology on p. 10-15

SARS-CoV-2 RBD Neutralizing Antibody Induction is Enhanced by Particulate Vaccination.

Wei Chiao Huang, Shiqi Zhou, Xuedan He, Kevin Chiem, Moustafa T. Mabrouk, Ruth H. Nissly, Ian M. Bird, Mike Strauss, Suryaprakash Sambhara, Joaquin Ortega, Elizabeth A. Wohlfert, Luis Martinez-Sobrido, Suresh V. Kuchipudi, Bruce A. Davidson, Jonathan F. Lovell, 2020, Advanced Materials on p. e2005637

Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization

Eric Salazar, Suresh V. Kuchipudi, Paul A. Christensen, Todd Eagar, Xin Yi, Picheng Zhao, Zhicheng Jin, S. Wesley Long, Randall J. Olsen, Jian Chen, Brian Castillo, Christopher Leveque, Dalton Towers, Jason Lavinder, Jimmy Gollihar, Jose Cardona, Gregory Ippolito, Ruth Nissly, Ian Bird, Denver Greenawalt, Randall M. Rossi, Abhinay Gontu, Sreenidhi Srinivasan, Indira Poojary, Isabella M. Cattadori, Peter J. Hudson, Nicole M. Josleyn, Laura Prugar, Kathleen Huie, Andrew Herbert, David W. Bernard, John M. Dye, Vivek Kapur, James M. Musser, 2020, Journal of Clinical Investigation on p. 6728-6738

Most-Cited Papers

18S rRNA is a reliable normalisation gene for real time PCR based on influenza virus infected cells

Suresh V. Kuchipudi, Meenu Tellabati, Rahul K. Nelli, Gavin A. White, Belinda Baquero Perez, Sujith Sebastian, Marek J. Slomka, Sharon M. Brookes, Ian H. Brown, Stephen P. Dunham, Kin Chow Chang, 2012, Virology Journal

Cytokines

Alti Dayakar, Sambamurthy Chandrasekaran, Suresh V. Kuchipudi, Suresh K. Kalangi, 2019, Frontiers in Immunology

Highly pathogenic avian influenza virus infection in chickens but not ducks is associated with elevated host immune and pro-inflammatory responses

Suresh V. Kuchipudi, Meenu Tellabati, Sujith Sebastian, Brandon Z. Londt, Christine Jansen, Lonneke Vervelde, Sharon M. Brookes, Ian H. Brown, Stephen P. Dunham, Kin Chow Chang, 2014, Annales de Recherches Veterinaires on p. 118

The Complex Role of STAT3 in Viral Infections

Suresh V. Kuchipudi, 2015, Journal of Immunology Research

Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization

Eric Salazar, Suresh V. Kuchipudi, Paul A. Christensen, Todd Eagar, Xin Yi, Picheng Zhao, Zhicheng Jin, S. Wesley Long, Randall J. Olsen, Jian Chen, Brian Castillo, Christopher Leveque, Dalton Towers, Jason Lavinder, Jimmy Gollihar, Jose Cardona, Gregory Ippolito, Ruth Nissly, Ian Bird, Denver Greenawalt, Randall M. Rossi, Abhinay Gontu, Sreenidhi Srinivasan, Indira Poojary, Isabella M. Cattadori, Peter J. Hudson, Nicole M. Josleyn, Laura Prugar, Kathleen Huie, Andrew Herbert, David W. Bernard, John M. Dye, Vivek Kapur, James M. Musser, 2020, Journal of Clinical Investigation on p. 6728-6738

Rapid death of duck cells infected with influenza

Suresh V. Kuchipudi, Stephen P. Dunham, Rahul Nelli, Gavin AWhite, Vivien J. Coward, Marek J. Slomka, Ian H. Brown, Kin Chow Chang, 2012, Immunology and Cell Biology on p. 116-123

A simplified but robust method for the isolation of avian and mammalian muscle satellite cells

Belinda Baquero-Perez, Suresh V. Kuchipudi, Rahul K. Nelli, Kin Chow Chang, 2012, BMC Cell Biology

Pathogenicity and tissue tropism of infectious bronchitis virus is associated with elevated apoptosis and innate immune responses

Rajesh Chhabra, Suresh V. Kuchipudi, Julian Chantrey, Kannan Ganapathy, 2016, Virology on p. 232-241

Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus release

Rahul K. Nelli, Stephen P. Dunham, Suresh V. Kuchipudi, Gavin A. White, Belinda Baquero-Perez, Pengxiang Chang, Amir Ghaemmaghami, Sharon M. Brookes, Ian H. Brown, Kin Chow Chang, 2012, Journal of Virology on p. 9201-9210

Heat shock protein 70 (Hsp70) mediates Zika virus entry, replication, and egress from host cells

Sujit Pujhari, Marco Brustolin, Vanessa M. Macias, Ruth H. Nissly, Masashi Nomura, Suresh V. Kuchipudi, Jason L. Rasgon, 2019, Emerging Microbes and Infections on p. 8-16

News Articles Featuring Suresh Kuchipudi

New tool predicts changes that may make COVID variants more infectious

The first key step in SARS-CoV-2 infection is when the virus’ spike protein binds to the ACE2 receptor on human cells. Researchers at Penn State have created a novel framework that can predict with reasonable accuracy the amino-acid changes in the virus’ spike protein that may improve its binding to human cells and confer increased infectivity to the virus.

Meme Spreads Falsehood About Vaccine Transfer Through Eating Meat

Livestock and poultry are not being vaccinated against COVID-19. But a meme is spreading the falsehood that those who eat meat from vaccinated animals will get “VAXXED” by consuming the meat. That simply isn’t possible, according to immunologists.

Tool can provide swine producers with early diagnosis of often-fatal 'Strep zoo'

A team led by researchers in Penn State's College of Agricultural Sciences has developed a diagnostic test that can identify virulent forms of the swine bacterial pathogen Streptococcus equi subspecies zooepidemicus — often referred to as "Strep zoo" — which can cause severe illness and death in pigs, other animals and rarely people.

Study finds short window for donating convalescent plasma to COVID-19 patients

The optimal timeframe for donating convalescent plasma for use in COVID-19 immunotherapy, which was given emergency-use authorization by the Food and Drug Administration in August 2020, is within 60 days of the onset of symptoms, according to a new Penn State-led study.

Study finds short window for donating convalescent plasma to COVID-19 patients

The optimal timeframe for donating convalescent plasma for use in COVID-19 immunotherapy, which was given emergency use authorization by the Food and Drug Administration in August 2020, is within 60 days of the onset of symptoms, according to a new study. The research also reveals that the ideal convalescent plasma donor is a recovered COVID-19 patient who is older than 30 and whose illness had been severe.

Penn State researcher part of project to develop novel COVID-19 vaccine

A researcher in Penn State's College of Agricultural Sciences is part of a team of scientists working to develop a unique COVID-19 vaccine that uses a bovine adenovirus as a safe and effective delivery vehicle.

Penn State researchers to study novel coronavirus potential to infect livestock

A grant from the U.S. Department of Agriculture will enable Penn State researchers to study the potential for SARS-CoV-2, the novel coronavirus that causes COVID-19, to infect and spread among livestock.

Battling disease with ultraviolet light

A new seed grant-funded study could provide the knowledge base needed to develop optical radiation products to sanitize large indoor environments to prevent the transmission of viruses like SARS-CoV-2.

'The reason we do this is to save lives’: An inside look at coronavirus research efforts at Penn State

As cases of the coronavirus began spreading globally and increasing in numbers, scientists have been racing to the forefront to attempt to understand and combat the virus.

Expert: 'There is no need to panic' after a tiger tests positive for COVID-19

A tiger at the Bronx Zoo has tested positive for coronavirus, believed to have been infected by an employee who wasn't yet showing symptoms, the zoo in New York said.