Squire Booker
Evan Pugh Professor of Chemistry; Professor of Biochemistry and Molecular Biology
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104 Chemistry
University Park, PA 16802 - sjb14@psu.edu
- 814-865-8793
Research Summary
Elucidating the chemical mechanisms by which enzymes containing iron-sulfur clusters catalyze chemical reactions. Most ongoing projects deal with members of the Radical S-adenosylmethionine Superfamily, a diverse group of enzymes that employ radical chemistry to catalyze transformations involved in post-transcriptional and post-translational modifications, cofactor biosynthesis, secondary metabolite biosynthesis, and enzyme activation.
Huck Affiliations
Links
Publication Tags
Enzymes S Adenosylmethionine Oxidation Reduction Aldehydes Proteins Formic Acid Oxygenases Methylation Electrons Substrates Aldehyde Decarbonylase Iron Biosynthesis Fatty Aldehyde Ferredoxins Catalysis Sulfur Peroxides Peptides Carbon Monoxide Escherichia Coli X Ray Crystallography Methyltransferases Oxygen AcidsMost Recent Papers
First step in catalysis of the radical s-adenosylmethionine methylthiotransferase MiaB yields an intermediate with a [3Fe-4S]0-like auxiliary cluster
Bo Zhang, Arthur J. Arcinas, Matthew I. Radle, Alexey Silakov, Squire J. Booker, Carsten Krebs, 2020, Journal of the American Chemical Society on p. 1911-1924
The Expanding Role of Methyl-Coenzyme M Reductase in the Anaerobic Functionalization of Alkanes.
D Miller, Squire Booker, 2019, Biochemistry on p. 4269-4271
An unexpected species determined by X-ray crystallography that may represent an intermediate in the reaction catalyzed by quinolinate synthase
Olga A. Esakova, Alexey Silakov, Tyler L. Grove, Douglas M. Warui, Neela H. Yennawar, Squire J. Booker, 2019, Journal of the American Chemical Society on p. 14142-14151
Understanding the role of electron donors in the reaction catalyzed by Tsrm, a cobalamin-dependent radical S-adenosylmethionine methylase
Anthony J. Blaszczyk, Hayley L. Knox, Squire J. Booker, 2019, Journal of Biological Inorganic Chemistry on p. 831-839
Methanogenesis marker protein 10 (Mmp10) from Methanosarcina acetivorans is a radical S-adenosylmethionine methylase that unexpectedly requires cobalamin
M Radle, D Miller, T Laremore, Squire Booker, 2019, The Journal of Biological Chemistry on p. 11712-11725
Analysis of RNA Methylation by Phylogenetically Diverse Cfr Radical S-Adenosylmethionine Enzymes Reveals an Iron-Binding Accessory Domain in a Clostridial Enzyme
James D. Gumkowski, Ryan J. Martinie, Patrick S. Corrigan, Juan Pan, Matthew R. Bauerle, Mohamed Almarei, Squire J. Booker, Alexey Silakov, Carsten Krebs, Amie Kathleen Boal, 2019, Biochemistry on p. 3169-3184
Capturing Intermediates in the Reaction Catalyzed by NosN, a Class C Radical S-Adenosylmethionine Methylase Involved in the Biosynthesis of the Nosiheptide Side-Ring System
Bo Wang, Joseph W. Lamattina, Savannah L. Marshall, Squire J. Booker, 2019, Journal of the American Chemical Society on p. 5788-5797
Stuffed methyltransferase catalyzes the penultimate step of pyochelin biosynthesis
Trey A. Ronnebaum, Jeffrey S. McFarlane, Thomas E. Prisinzano, Squire J. Booker, Audrey L. Lamb, 2019, Biochemistry on p. 665-678
Parsing redox potentials of five ferredoxins found within Thermotoga maritima
Stephanie J. Maiocco, Arthur J. Arcinas, Squire J. Booker, Sean J. Elliott, 2019, Protein Science on p. 257-266
Ferredoxins as interchangeable redox components in support of MiaB, a radical S-adenosylmethionine methylthiotransferase
Arthur J. Arcinas, Stephanie J. Maiocco, Sean J. Elliott, Alexey Silakov, Squire J. Booker, 2019, Protein Science on p. 267-282
Most-Cited Papers
A radically different mechanism for S-adenosylmethionine-dependent methyltransferases
Tyler L. Grove, Jack S. Benner, Matthew I. Radle, Jessica H. Ahlum, Bradley J. Landgraf, Carsten Krebs, Squire J. Booker, 2011, Science on p. 604-607
Structural basis for methyl transfer by a radical SAM enzyme
Amie Kathleen Boal, Tyler L. Grove, Monica I. McLaughlin, Neela Yennawar, Squire J. Booker, Amy C. Rosenzweig, 2011, Science on p. 1089-1092
Radical S-Adenosylmethionine Enzymes in Human Health and Disease
Bradley J. Landgraf, Erin L. McCarthy, Squire J. Booker, 2016, Annual Review of Biochemistry on p. 485-514
Evidence for only oxygenative cleavage of aldehydes to alk(a/e)nes and formate by cyanobacterial aldehyde decarbonylases
Ning Li, Wei Chen Chang, Douglas Warui, Squire J. Booker, Carsten Krebs, Joseph M. Bollinger, Jr., 2012, Biochemistry on p. 7908-7916
Detection of formate, rather than carbon monoxide, as the stoichiometric coproduct in conversion of fatty aldehydes to alkanes by a cyanobacterial aldehyde decarbonylase
Douglas M. Warui, Ning Li, Hanne Nørgaard, Carsten Krebs, J. Martin Bollinger, Squire J. Booker, 2011, Journal of the American Chemical Society on p. 3316-3319
Conversion of fatty aldehydes to alka(e)nes and formate by a cyanobacterial aldehyde decarbonylase: Cryptic redox by an unusual dimetal oxygenase
Ning Li, Hanne Nørgaard, Douglas M. Warui, Squire J. Booker, Carsten Krebs, J. Martin Bollinger, 2011, Journal of the American Chemical Society on p. 6158-6161
X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification
Peter J. Goldman, Tyler L. Grove, Lauren A. Sites, Martin I. McLaughlin, Squire J. Booker, Catherine L. Drennan, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 8519-8524
A high-throughput screen for quorum-sensing inhibitors that target acyl-homoserine lactone synthases
Quin H. Christensen, Tyler L. Grove, Squire J. Booker, E. Peter Greenberg, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. 13815-13820
RlmN and AtsB as models for the overproduction and characterization of radical SAM proteins
Nicholas D. Lanz, Tyler L. Grove, Camelia Baleanu Gogonea, Kyung Hoon Lee, Carsten Krebs, Squire J. Booker, 2012, Methods in enzymology on p. 125-152
Substrate-triggered addition of dioxygen to the diferrous cofactor of aldehyde-deformylating oxygenase to form a diferric-peroxide intermediate
Maria E. Pandelia, Ning Li, Hanne Nørgaard, Douglas Warui, Lauren J. Rajakovich, Wei Chen Chang, Squire J. Booker, Carsten Krebs, Joseph M. Bollinger, Jr., 2013, Journal of the American Chemical Society on p. 15801-15812
News Articles Featuring Squire Booker
Jan 18, 2021
Synthesis of potent antibiotic follows unusual chemical pathway
Images of a protein involved in creating a potent antibiotic reveal the unusual first steps of the antibiotic’s synthesis. The improved understanding of the chemistry behind this process, detailed in a new study led by Penn State chemists, could allow researchers to adapt this and similar compounds for use in human medicine.
Full Article
Sep 30, 2020
Mapping a trail of chemical reactions, Howard Hughes Investigator Squire Booker shows how one group of enzymes helps us stay healthy
Mapping a trail of chemical reactions, Howard Hughes Investigator Squire Booker shows how one group of enzymes helps us stay healthy
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May 01, 2019
Squire Booker Elected as Member of the National Academy of Sciences
Squire J. Booker, professor of chemistry and of biochemistry and molecular biology at Penn State, Holder of the Eberly Distinguished Chair in Science, and investigator with the Howard Hughes Medical Institute, has been elected as a member of the National Academy of Sciences.
Full Article